acetylcysteine has been researched along with cysteine in 555 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 181 (32.61) | 18.7374 |
| 1990's | 142 (25.59) | 18.2507 |
| 2000's | 121 (21.80) | 29.6817 |
| 2010's | 91 (16.40) | 24.3611 |
| 2020's | 20 (3.60) | 2.80 |
| Authors | Studies |
|---|---|
| Parish, HA; Spatola, AF; Yankeelov, JA | 1 |
| DeMaster, EG; Goon, DJ; Nagasawa, HT | 1 |
| Goon, DJ; Nagasawa, HT; Yuzon, DL; Zera, RT | 1 |
| Cheng, JP; Wang, K; Wang, PG; Wen, Z; Xian, M; Zhang, W | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brüsewitz, G; Cameron, BD; Chasseaud, LF; Görler, K; Hawkins, DR; Koch, H; Mennicke, WH | 1 |
| Storr-Paulsen, A | 1 |
| Salemnick, G; Stöhrer, G | 1 |
| Moldéus, P; Orrenius, S; Thor, H | 1 |
| Giles, PM | 1 |
| Curthoys, NP; Elce, JS; Hughey, RP; Rankin, BB | 1 |
| Johannsen, B; Münze, R; Spies, H; Syhre, R | 1 |
| Moldéus, P | 1 |
| Levy, G; Slattery, JT | 1 |
| Buckpitt, AR; Franklin, RB; Mitchell, JR; Nelson, SD; Rollins, DE | 1 |
| Baines, PJ; Bray, HG; James, SP | 1 |
| Davis, M; Harrison, NG; Simmons, CJ; Williams, R | 1 |
| Cederbaum, AI; Rubin, E | 1 |
| Bakke, JE; Feil, VJ; Price, CE | 1 |
| Ledl, F | 1 |
| Andrews, RS; Bond, CC; Burnett, J; Saunders, A; Watson, K | 1 |
| Davis, M; Labadarios, D; Williams, RS | 1 |
| Gershon, H; Hauck, JB; Parmegiani, R | 1 |
| Abbasi, AH; Cestero, RV; Clarkson, TW; Freeman, RB; Kostyniak, PJ | 1 |
| Gonzales, LJ; Parker, CM; Smith, GG; Sprince, H | 1 |
| Draeger, J; Hohorst, HJ; Peter, G | 1 |
| Sun, CP; Sun, JZ; Tang, LD; Tang, ZM; Wu, K | 1 |
| Dröge, W; Eck, HP; Mihm, S | 1 |
| de Quay, B; Lauterburg, BH; Malinverni, R | 1 |
| Das, SK; Fanburg, BL; White, AC | 1 |
| Gasco, E; Gimenez, A; Puertes, IR; Viña, J; Viña, JR | 1 |
| Daley, DL; Deneke, SM; Fanburg, BL; Phelps, DT | 1 |
| Bakke, JE; Davison, KL; Larsen, GL | 1 |
| Eisenbart, J; Fless, GM; Hinman, J; Makino, K; Pfaffinger, D; Scanu, AM | 1 |
| Mulder, GJ; Nagelkerke, JF; Viver, MM | 1 |
| Baker, DH; Wood, RJ | 1 |
| Chen, TS; Lang, CA; Richie, JP | 1 |
| Adams, LM; Borella, LE; Caccese, RG; DiJoseph, JF; Skotnicki, JS | 1 |
| Hill, L; Lailey, AF; Lawston, IW; Stanton, D; Upshall, DG | 1 |
| Tang, LD; Tang, ZM | 1 |
| Critchley, JA; Leung, NW | 1 |
| Bridgeman, MM; Flenley, DC; MacNee, W; Marsden, M; Ryle, AP | 1 |
| Bridgeman, MM; Brown, D; Donaldson, K; Drost, E; Lannan, S; MacNee, W; Selby, C | 1 |
| Cañada, FJ; Pérez-Sala, D; Rando, RR; Tan, EW | 1 |
| Dröge, W; Ennen, J; Kurth, R; Mihm, S; Pessara, U | 1 |
| Boogaard, PJ; Commandeur, JN; Mulder, GJ; Vermeulen, NP | 1 |
| Chong, S; Fung, HL | 1 |
| Andrews, MA; Jenkins, SM; Livingstone, CR; Marriott, C | 1 |
| Grotyohann, LW; Martin, LF; Scaduto, RC; Slusser, SO | 1 |
| Dekant, W; Heuner, A; Schwegler, JS; Silbernagl, S | 1 |
| Carenzi, A; Di Toro, M; Galimberti, C; Longo, A | 1 |
| Commandeur, JN; Stijntjes, GJ; Vermeulen, NP; Wijngaard, J | 1 |
| Brötell, H; Hallberg, A; Karg, E; Rorsman, H; Rosengren, E; Tunek, A | 1 |
| Lunte, CE; Lunte, SM; Puckett, DL; Stenken, JA | 1 |
| Stevens, JL; Wallin, A | 1 |
| Brasch, H; Pentz, R; Strubelt, O; Younes, M | 1 |
| Bakke, JE; Davison, KL | 1 |
| Golenhofen, N; Heuner, A; Mildenberger, S; Schwegler, JS; Silbernagl, S | 1 |
| Birkett, DJ; Lelo, A; Miners, JO | 1 |
| Babiuk, C; Benz, FW; Nerland, DE; Pierce, WM | 1 |
| Denneberg, T; Lindell, A; Mårtensson, J; Textorius, O | 1 |
| Boogaard, PJ; Mulder, GJ; Nagelkerke, JF; van Berkel, TJ; van't Noordende, JM; Zoeteweij, JP | 1 |
| Chau, DD; Cheung, HT; Earl, J; Overton, J; Wark, H | 1 |
| Imamura, N; Misawa, M | 1 |
| Baillie, TA; Howald, WN; Pearson, PG; Rashed, MS | 1 |
| Ekman, L; Magnusson, I; Wahren, J; Wångdahl, M | 1 |
| Jeffery, PK; Marriott, C; Rogers, DF; Turner, NC | 1 |
| Boogaard, PJ; Commandeur, JN; Mulder, GJ; Nagelkerke, JF; Vermeulen, NP | 1 |
| Bast, A; Haenen, GR; Timmerman, H; Vermeulen, NP | 1 |
| Furukawa, T; Palacin, M; Perez, C; Viña, J; Viña, JR | 1 |
| Burka, LT; Deterding, LJ; Mahmood, NA; Srinivas, P; Tomer, KB | 1 |
| Kredich, NM; Ostrowski, J | 1 |
| Casas, JS; Filella, M; García Bugarín, M; Sordo, J | 1 |
| Burgunder, JM; Lauterburg, BH; Varriale, A | 1 |
| Stevens, JL; Zhang, GH | 1 |
| Nelson, SD; Rashed, MS | 1 |
| Kress, G; Pentz, R | 1 |
| Akagi, M; Ando, Y; Hirayama, K; Hirota, M; Inoue, M; Mori, K; Morino, Y; Sakamoto, K | 1 |
| Commandeur, JN; De Kanter, FJ; Vermeulen, NP | 1 |
| Fischer, V; Mason, RP; Schreiber, J; Takahashi, N | 1 |
| Birchall, JP; FitzGerald, JE; Green, GG; Pearson, JP; Stafford, FW | 1 |
| Marriott, C | 1 |
| Gemborys, MW; Hoefle, D; Hook, JB; Mudge, GH; Newton, JF | 1 |
| Noack, E; Schröder, H | 1 |
| Anders, MW; Dekant, W; Elfarra, AA; Henschler, D; Vamvakas, S | 1 |
| Clark, DE; Grant, NH; Wei, P | 1 |
| Moldéus, P; Norbeck, K; Ross, D | 1 |
| Mason, RP; Mottley, C; Toy, K | 1 |
| Corbella, J; Domingo, JL; Llobet, JM | 1 |
| Bergman, A; Brandt, I; Klasson-Wehler, E; Kowalski, B | 1 |
| Feelisch, M; Noack, E | 1 |
| Bässler, KH; Böhler, S; Neuhäuser-Berthold, M; Virmani, K; Wagner, K | 1 |
| Czarnomska, A; Czyzewska-Szafran, H; Danysz, A; Jastrzebski, Z | 1 |
| Jones, TW; Qin, C; Schaeffer, VH; Stevens, JL | 1 |
| Brodeur, J; Gérin, M; Tardif, R | 1 |
| Brakenhoff, JP; Commandeur, JN; De Kanter, FJ; Vermeulen, NP | 1 |
| Baille, TA; Calleman, CJ; Pascoe, GA | 1 |
| Johannson, M; Lenngren, S | 1 |
| Abián, J; Casas, J; Conchillo, A; Messeguer, A | 1 |
| Deterding, LJ; Dino, JJ; Guenat, C; Tomer, KB | 1 |
| Yeung, JH | 1 |
| al-Kabban, M; Reglinski, J; Smith, WE; Stewart, MJ; Suckling, CJ; Watson, ID | 1 |
| Jandke, J; Spiteller, G | 1 |
| Ammon, HP; Enz, G; Hehl, KH; Setiadi-Ranti, A; Verspohl, EJ | 1 |
| Critchley, JA; Gregson, CA; Nimmo, GR; Prescott, LF; Woolhouse, NM | 1 |
| Friedman, M; Gumbmann, MR | 2 |
| Inoue, M; Morino, Y; Nagase, S; Okajima, K | 1 |
| Budini, R; Fraticelli, A; Guarnieri, C; Vaona, I; Ventura, C | 1 |
| Lock, EA; Odum, J; Ormond, P | 1 |
| Hall, BE; James, SP | 1 |
| Hayden, P; Stevens, J; Taylor, G | 1 |
| Ishmael, J; Lock, EA | 2 |
| Stiel, L; Wapnir, RA | 1 |
| Brussee, J; Mulder, GJ; Olde Boerrigter, JC; te Koppele, JM; van der Gen, A; van der Greef, J; van der Mark, EJ | 1 |
| Cotgreave, IA; Eklund, A; Larsson, K; Moldéus, PW | 1 |
| Hesk, D; Hutson, DH; Logan, CJ | 1 |
| Sprince, H | 1 |
| Judah, DJ; Moss, EJ; Neal, GE | 1 |
| Clark, AG; Ong, LK | 1 |
| Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Krivanek, ND; McLaughlin, M; Sprout, WL; Trochimowicz, HJ | 1 |
| Barnsley, EA; Gray, JM | 1 |
| Sugar, A; Waltman, SR | 1 |
| James, SP; Needham, D | 1 |
| Primack, A | 1 |
| Hollinger, HZ; Kisil, FT; Sehon, AH | 1 |
| Clapp, JJ; Kaye, CM; Young, L | 1 |
| Elce, JS | 1 |
| Lightowler, JE; Lightowler, NM | 1 |
| Bray, HG; Carpanini, FM; Waters, BD | 1 |
| Atoynatan, T; Bartfeld, H | 1 |
| Corrocher, R; Cortesi, S; De Sandre, G; Perona, G; Vettore, L | 1 |
| Schulman, JD; Shih, VE | 1 |
| Bray, HG; Garrett, AJ; James, SP | 1 |
| Bailey, KR; Gallo, DG; Medler, EM; Mueller, AJ; Sarett, HP; Sheffner, AL | 1 |
| DeLong, DC; Redman, CE; Streightoff, F | 1 |
| Galzigna, L; Saia, B; Terribile, P | 1 |
| Barry, BK; Edwards, JC; Gruetter, CA; Gruetter, DY; Ignarro, LJ | 1 |
| Dunn, JA; Greenberg, RN; Guerrant, RL | 1 |
| Berggren, M; Dawson, J; Moldéus, P | 1 |
| Baars, AJ; Breimer, DD | 1 |
| Bennicelli, C; Camoirano, A; De Flora, A; De Flora, S; Morelli, A; Zanacchi, P | 1 |
| Linden, CH; Rumack, BH | 1 |
| Birkett, DJ; Drew, R; Miners, JO | 1 |
| Friedman, M; Grosjean, OK; Gumbmann, MR | 1 |
| Cottee, FH; Logan, CJ; Page, JA | 1 |
| Mitchell, JB; Russo, A | 1 |
| Delaforge, M; Hall, DE; Ioannides, C; Mulder, DE; Parke, DV; Spickett, J; Steele, CM | 1 |
| Estrela, JM; Sáez, GT; Such, L; Viña, J | 1 |
| Cennerazzo, MJ; Field, D; Reddy, MK; Snyder, GH | 1 |
| Inoue, M; Morino, Y; Okajima, K | 1 |
| Aleĭnikov, VG; Burushkina, TN; Evdokimenko, VM; Kokarovtseva, MG; Stavinskiĭ, VB | 1 |
| Clare, DA; Horton, HR; Sliwkowski, MX; Swaisgood, HE | 1 |
| Inoue, M; Itoh, K; Morino, Y; Okajima, K | 1 |
| Forte, AJ; Gillette, JR; Hinson, JA; Mitchell, JR; Nelson, SD; Vaishnav, Y | 1 |
| Stossel, TP; Weitzman, SA | 1 |
| Pallardó, FV; Romero, FJ; Saez, GT; Viña, J | 1 |
| Roomans, GM; Tegner, H; Toremalm, NG | 1 |
| Maddock, J | 1 |
| Litt, M; Marriott, C; Martin, R | 1 |
| Black, M | 1 |
| Kissinger, PT; Rice, JR | 1 |
| Larsen, GL; Ryhage, R | 1 |
| Antonucci, R; Ippolito, S; Maronne, V; Matrisciano, F; Menna, F | 1 |
| Gut, I; Kopecký, J; Zachardová, D | 1 |
| Gruber, C; Gruber, DK; Lent, R; Levenson, SM; Seifter, E | 1 |
| Balali-Mood, M; Critchley, JA; Pentland, B; Prescott, LF | 1 |
| Chalabala, M; Springer, V; Struhár, M | 1 |
| Imamura, N; Misawa, M; Yanaura, S | 1 |
| Anzai, N; Chida, S; Kimura, T; Meguro, H; Takahashi, H; Tanaka, T | 1 |
| Calder, I; Hart, S; Ross, B; Tange, J | 1 |
| Braun, WH; Langvardt, PW; Putzig, CL; Young, JD | 1 |
| Issels, RD; Meier, T | 1 |
| Castresana, MR; Jollow, DJ; McDonald, MH; Newman, WH; Zhang, LM | 1 |
| Goto, S; Hong, YM; Hori, H; Majima, E; Shinohara, Y; Terada, H | 1 |
| Jonas, JC; Regazzi, R; Sasaki, T; Stock, JB; Takahashi, K; Takai, Y; Volker, C; Wollheim, CB | 1 |
| Alexandre, E; Boudjema, K; Chenard, MP; Cinqualbre, J; Imbs, P; Jaeck, D; Nakano, H; Wolf, P | 1 |
| Bockstette, M; Dröge, W; Fischbach, T; Galter, D; Gmünder, H; Kinscherf, R; Mihm, S; Roth, S | 1 |
| Finkel, MS; Oddis, CV; Romeo, RC; Salama, G; Shen, L | 1 |
| Gierschik, P; Scheer, A | 1 |
| Agvald, P; Gustafsson, LE; Persson, MG | 2 |
| Elfarra, AA | 1 |
| Junker, E; Lauterburg, BH; Schranz, C; Speck, RF; Witschi, A | 1 |
| Dröge, W; Galter, D; Mihm, S | 1 |
| Davies, MJ; Puppo, A | 1 |
| Hallberg, A; Särnstrand, B; Sjödin, K; Tunek, A | 1 |
| Dantzler, WH; Evans, KK; Wright, SH | 1 |
| Keaney, JF; Loscalzo, J; Scharfstein, JS; Slivka, A; Stamler, JS; Vita, JA; Welch, GN | 1 |
| Camerino, DC; Tricarico, D | 1 |
| Chung, FL; Foiles, P; Ho, CT; Jiao, D | 1 |
| Baraban, JM; Murphy, TH; Ratan, RR | 1 |
| Banks, MF; Stipanuk, MH | 1 |
| Bernard, GR; Morris, PE | 1 |
| Akerlund, B; Jarstrand, C | 1 |
| Benzick, AE; Gomez, MR; Heird, WC; Rogers, LK; Smith, CV | 1 |
| Dalal, NS; Kasprzak, KS; Shi, X | 1 |
| Dröge, W | 2 |
| Lopez Garcia, I; Martinez Gil, JA; Viñas, P | 1 |
| Commandeur, JN; Gandolfi, AJ; McGuinness, S; Stijntjes, GJ; te Koppele, JM; Vermeulen, NP | 1 |
| Esteban, A; Graells, ML; Mayole, MJ; Pérez-Mateo, M; Satorres, J | 1 |
| Butterworth, M; Cohen, GM; Hobbs, M; Upshall, DG | 1 |
| Lock, EA | 1 |
| Chiba, T; Ishii, S; Kikuchi, K; Sato, N; Takahashi, S | 1 |
| Andersson, T; Hellberg, C; Molony, L; Ng-Sikorski, J | 1 |
| Fau, D; Fouraste, I; Lekehal, M; Lereau, JM; Moulis, C; Pessayre, D | 1 |
| Daigle, DJ; De Lucca, AJ; Walsh, TJ | 1 |
| Boogaard, PJ; Commandeur, JN; de Rooij, BM; Groot, EJ; Vermeulen, NP | 1 |
| Ercal, N; Grannemann, NH; Hammond, TC; Matthews, RH; Spitz, DR; Treeratphan, P | 1 |
| Ali, SF; Hussain, S; Slikker, W | 1 |
| Akerblad, AC; Akerlund, B; Jarstrand, C; Lindeke, B; Rasool, O; Sönnerborg, A | 1 |
| Chung, FL; Conaway, CC; Jiao, D; Koehl, W; Wang, MH; Yang, CS | 1 |
| Bockstette, M; Dröge, W; Galter, D; Gross, A; Hack, V; Kinscherf, R; Mihm, S; Schykowski, M | 1 |
| Kawase, M; Kinoshita, C; Murata, H; Nakata, K; Ogata, K; Ogino, S; Ohmori, S; Sakaue, T | 1 |
| Kinuta, M; Sasaki, K; Shimizu, H; Ubuka, T | 1 |
| Hinze, H; Lenz, AG; Maier, KL; Meyer, B | 1 |
| Ikuta, K; Kameoka, M; Kimura, T; Okada, Y; Tobiume, M | 1 |
| Bernauer, U; Birner, G; Dekant, W; Henschler, D | 1 |
| Caffrey, R; McCoy, KL; Merkel, BJ; Short, S | 1 |
| Brazil, DP; Parish, CA; Rando, RR | 1 |
| Bjerregaard, J; Eriksen, L; Murrell, KD; Nansen, P; Roepstorff, A; Slotved, HC | 1 |
| Behar, S; He, D; Lim, HW; Roberts, JE | 1 |
| Lailey, AF | 1 |
| Numazawa, M; Tachibana, M | 1 |
| Capodaglio, E; Cavalleri, A; Ghittori, S; Gobba, F; Imbriani, M; Maestri, L | 1 |
| Blazer-Yost, BL; Hughes, CL; Nolan, PL | 1 |
| Arons, MM; Bernard, GR; Morris, PE; Paz, HL; Russell, JA; Wheeler, AP; Wright, PE | 1 |
| Anders, MW; Otieno, MA | 1 |
| Grong, K; Ovrebø, KK; Svanes, K; Svardal, A; Sørbye, H | 1 |
| Arstrand, K; Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Bernal, JL; Manzanas, L; Marinero, P; Moral, O; Nozal, MJ; Rodriguez, E; Toribio, L | 1 |
| Beani, JC; Emonet, N; Favier, A; Leccia, MT; Richard, MJ | 1 |
| Akerlund, B; Bielenstein, M; Bratt, G; Lidman, C; Tynell, E | 1 |
| Barber, T; García, C; Puertes, IR; Sastre, J; Triguero, A; Viña, JR | 1 |
| de Matos, DG; Furnus, CC; Moses, DF | 1 |
| Bernauer, U; Birner, G; Dekant, W; Werner, M | 1 |
| Inoue, M; Kashiba, M; Kuroki, T; Nishikawa, M; Sato, EF; Utsumi, K | 1 |
| de Koster, BM; Elferink, JG | 1 |
| Imai, S; Ishibashi, T; Kitagawa, T | 1 |
| Acara, MA; Lohr, JW; Willsky, GR | 1 |
| Barfuss, DW; Zalups, RK | 2 |
| Ballatori, N; Clifton, D; Rebbeor, JF; Wang, W | 1 |
| Field, MC; Nesbeth, DN; Wainwright, LJ; Wilbourn, B | 1 |
| Cañada, FJ; Gilbert, BA; Pérez-Sala, D; Rando, RR | 1 |
| Katagiri, Y; Nakamura, M; Nakashima, S; Nozawa, Y | 1 |
| Bernhard, MC; Hettinger, A; Junker, E; Lauterburg, BH | 1 |
| Baker, WL; Chen, XP; Clark, AG; Cross, RF | 1 |
| Fauler, J; Frölich, JC; Ikic, M; Sandmann, J; Stichtenoth, DO; Tsikas, D | 1 |
| Natsuki, R; Tanaka, M | 1 |
| Cohen, G; Ogwu, V | 1 |
| Cao, K; Cavalieri, EL; Gross, ML; Ramanathan, R; Rogan, EG; Stack, DE | 1 |
| Zalups, RK | 1 |
| Gräslund, A; Karlberg, AT; Nilsson, JL; Scheynius, A; Van den Broeke, LT; Wahlberg, JE | 1 |
| Rorsman, H; Rosengren, E | 1 |
| Biaglow, J; Held, K; Horan, AM; Koch, CJ; Manevich, Y; Tuttle, S | 1 |
| Cooper, K; Ercal, N; Gurer, H; Neal, R | 1 |
| Shaikh, ZA; Vu, TT; Zaman, K | 1 |
| Aono, H; Kawashima, Y; Mita, S; Miyake, Y; Tsuji, F | 1 |
| Holland, LA; Lunte, SM | 1 |
| Dringen, R; Hamprecht, B | 1 |
| Chien, KC; Inoue, M; Kasahara, E; Kashiba, M | 1 |
| Barber, T; García, C; Martínez-López, I; Miralles, VJ; Torres, L; Triguero, A; Viña, JR | 1 |
| Frölich, JC; Gutzki, FM; Rossa, S; Sandmann, J; Tsikas, D | 1 |
| Blake, DR; Grootveld, M; Lynch, EJ; Patel, IY; Silwood, CJ | 1 |
| Fanburg, BL; Lanzillo, JJ; Lee, SL; Maloney, EK; White, AC | 1 |
| Botteron, C; Dobbelaere, DA; Fernandez, PC; Heussler, VT; Machado, J | 1 |
| Mazák, K; Noszál, B; Szakács, Z | 1 |
| Dröge, W; Hack, V; Ushmorov, A | 1 |
| Metodiewa, D; Winterbourn, CC | 1 |
| Panini, R; Pasini, MC; Salvioli, G; Scarpetta, G; Ventura, P | 1 |
| Jubert, C; Kharasch, ED | 1 |
| Haleva-Toledo, E; Naim, M; Rouseff, RL; Zehavi, U | 1 |
| Ahola, T; Fellman, V; Laaksonen, R; Laitila, J; Lapatto, R; Neuvonen, PJ; Raivio, KO | 1 |
| Kröning, R; Lichtenstein, AK; Nagami, GT | 1 |
| Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Hammarqvist, F; Wernerman, J | 1 |
| Breitkreutz, R; Dröge, W | 2 |
| Almassian, B; Doyle, TW; Lang, W; Mao, J; Niu, C; Wang, Q | 1 |
| Hermida-Ameijeiras, A; Labandeira-Garcia, JL; Méndez-Alvarez, E; Muñoz-Patiño, AM; Soto-Otero, R | 1 |
| Luft, FC | 1 |
| Béliveau, R; Desrosiers, RR; Gauthier, F; Lanthier, J | 1 |
| Aono, H; Horiuchi, M; Matsuoka, H; Mita, S; Nishimura, K; Takai, M; Tsuji, F | 1 |
| Deiss, VB; Grattagliano, I; Junker, E; Lauterburg, BH; Vendemiale, G | 1 |
| Dehnade, F; Li, WQ; Zafarullah, M | 1 |
| Aukrust, P; Berge, RK; Frøland, SS; Müller, F; Nordoy, I; Svardal, AM | 1 |
| Kala, G; Kala, SV; Kumar, TR; Lieberman, MW; Matzuk, MM; Wiseman, AL | 1 |
| Chévez-Barrios, P; Lieberman, MW; Ou, CN; Rojas, E; Wiseman, AL | 1 |
| Bondy, SC; Campbell, A; Yang, EY | 1 |
| Andersen, TT; Bennett, JA; Eisele, LE; Jacobson, HI; MacColl, R; Mesfin, FB; Mizejewski, GJ; Soldwedel, H | 1 |
| Harada, D; Hiraoka, I; Ishikawa, K; Kawauchi, Y; Koshitani, O; Naito, S; Otagiri, M | 1 |
| Ansorge, S; Dietzmann, J; Hinrich Neumann, K; Täger, M; Thiel, U | 1 |
| Davies, KJ; Demasi, M; Shringarpure, R | 1 |
| Jamieson, JD; Qiu, X; Valentijn, JA | 1 |
| Chung, AS; Jung, U; Yoon, SO; Zheng, X | 1 |
| Halliwell, B; Hua Long, L | 1 |
| Hermida-Ameijeiras, A; Labandeira-García, JL; López-Martín, ME; Méndez-Alvarez, E; Soto-Otero, R | 1 |
| Amarnath, V; Montine, TJ; Olson, SJ; Ou, JJ; Sidell, KR; Zhang, Y | 1 |
| Alessio, M; Arese, P; Bussolino, F; Ferrandi, C; Gruarin, P; Primo, L; Tandon, NN; Ulliers, D | 1 |
| Carney, EW; Hansen, JM; Harris, C | 1 |
| Gul Altuntas, T; Kharasch, ED | 1 |
| Kim, JR; Kwon, KS; Lee, SR; Rhee, SG; Yoon, HW | 1 |
| Bebensee, S; Dwivedi, C; Erickson, AK; Gilkerson, KK; Guan, X; Hoffman, BN; McFarland, DC; Pellegrini, J | 1 |
| Brechun, N; Diaz-Sanchez, D; Horwitz, LD; Horwitz, MA; Li, N; Nel, AE; Nelson, SK; Wang, M; Whitekus, MJ; Zhang, M | 1 |
| Ethiraj, KS; Hakimelahi, GH; Hakimelahi, S; Moosavi-Movahedi, AA; Pasdar, M; Sambaiah, T; Zhu, JL | 1 |
| Hiraku, Y; Kawanishi, S; Murata, M | 1 |
| Bahler, AA; Barrios, R; Kala, G; Kala, SV; Lieberman, MW; Ou, CN; Shi, ZZ; Welty, SE; Wiseman, AL | 1 |
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| Ali, F; Chattopadhyay, S; Das, A; Gonnade, RG; H A, A; Taye, N | 1 |
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| Ikeda, H; Nagamitsu, T; Shin-Ya, K; Tomoda, H | 1 |
| Ghazaghi, M; Mousavi, HZ; Shirkhanloo, H | 1 |
| Huseby, NE; Moens, U; Ravuri, C | 1 |
| Martínez-Banaclocha, M | 2 |
| He, X; Ma, H; Shi, W; Wu, X | 1 |
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| Lin, HC; Ma, L; Neu, J; Zhou, P | 1 |
| Bartsakoulia, M; Boczonadi, V; Gomez-Duran, A; Horvath, R; Mϋller, JS; Yu-Wai-Man, P | 1 |
| Martínez-Banaclocha, MA | 1 |
| Dairou, J; Richarme, G | 1 |
| Kishida, K; Maeda, S; Miwa, Y; Sasabe, T; Sugiyama, T; Yamano, M | 1 |
| Akaike, T; Ihara, H; Jung, M; Ono, K; Sawa, T; Sezaki, H; Tomizawa, K; Tsutsuki, H; Wei, FY; Zhang, T | 1 |
| Allegaert, K; Flint, RB; Knibbe, CAJ; Roofthooft, DW; Simons, SHP; Tibboel, D; van den Anker, JN; van Dijk, M; van Lingen, RA; van Rongen, A | 1 |
| Jalilian, J; Karimi, MY; Mohammadi, H; Shetab-Boushehri, SV | 1 |
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| Sandargo, B; Stadler, M; Surup, F; Thongbai, B | 1 |
| Borges-Santos, MD; Burini, RC; Moreto, F; Yu, YM | 1 |
| Dick, TP; Ezeriņa, D; Hanaoka, K; Takano, Y; Urano, Y | 1 |
| Abdenur, JE; Boyer, M; Di Meo, I; Eftekharian, S; Sowa, M; Steenari, MR; Tiranti, V | 1 |
| Dennis, K; Ding, WX; Li, J; Li, T; Matye, D; Wang, Y; Zhang, Y | 1 |
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| Andrejević, L; Cvetković, S; Djurić, D; Hrnčić, D; Jakovljević, V; Kostić, S; Labudović-Borović, M; Mićovic, Ž; Obrenović, R; Stamenković, A; Stanković, S | 1 |
| Borowczyk, K; Chwatko, G; Głowacki, R; Kamińska, A; Olejarz, P | 1 |
| Dalle Donne, I; Galvagni, F; Giustarini, D; Milzani, A; Rossi, R; Santucci, A; Severi, FM | 1 |
| Antunes, AMM; Coelho, NR; Correia, MJ; Gonçalves-Dias, C; Macedo, MP; Monteiro, EC; Morello, J; Pereira, SA; Soto, K | 1 |
| Cate, SA; Chen, J; Dominguez, M; Fu, X; Konkle, BA; López, JA; Osborn, W; Özpolat, T | 1 |
| Huang, CZ; Li, CM; Liu, JJ; Wang, J; Yan, HH; Yuan, D | 1 |
| Murata, Y; Nakamura, T; Nakamura, Y | 1 |
| Kubo, T; Lee, SH; Oe, T; Ozawa, M | 1 |
| Chen, Y; Ding, L; Du, Z; Liu, B; Liu, J; Wu, X; Xiao, H; Zhang, B; Zhang, H; Zhang, T | 1 |
| Chen, J; Gupta, A; Price, WS; Stait-Gardner, T; Yadav, NN; Zheng, G | 1 |
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31 review(s) available for acetylcysteine and cysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Collagenase inhibitors: rationale for their use in treating corneal ulceration.
Topics: Acetylcysteine; alpha 1-Antitrypsin; alpha-Macroglobulins; Animals; Calcium; Corneal Ulcer; Cyclic AMP; Cysteine; Disease Models, Animal; Edetic Acid; Humans; Microbial Collagenase; Protease Inhibitors; Steroids; Tropocollagen; Zinc Radioisotopes | 1975 |
HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine.
Topics: Acetylcysteine; Cysteine; Cystine; Glutamates; Glutamic Acid; Glutathione; HIV; HIV Infections; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxygen; Palliative Care; Superoxides; T-Lymphocytes | 1992 |
Cellular antioxidant status and human immunodeficiency virus replication.
Topics: Acetylcysteine; Antioxidants; Cysteine; Glutathione; HIV; HIV Infections; Humans; Sulfhydryl Compounds; Virus Replication | 1992 |
Is the toxicity of cysteine conjugates formed during mercapturic acid biosynthesis relevant to the toxicity of covalently bound drug residues?
Topics: Acetylcysteine; Animals; Biotransformation; Cysteine; Drug Residues; Glutathione; Intestinal Absorption; Sulfur | 1990 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Cysteine; Dose-Response Relationship, Drug; Glutathione; History, 20th Century; Humans; Kinetics; Liver Diseases; Prognosis; Prothrombin Time; Time Factors | 1984 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Glutathione; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Methionine | 1980 |
Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds.
Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Homocysteine; Mammals; Methionine; Oxidation-Reduction; Oxygenases; Sulfoxides | 1995 |
Significance of glutathione in lung disease and implications for therapy.
Topics: Acetylcysteine; Animals; Cysteine; Disease Models, Animal; Glutathione; Humans; Inflammation; Lung Diseases; NF-kappa B | 1994 |
Oxygen radical release by neutrophils of HIV-infected patients.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Cysteine; Female; Free Radicals; HIV Infections; Humans; Male; Neutrophils; Oxidation-Reduction; Randomized Controlled Trials as Topic; Superoxides | 1994 |
Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Amino Acids; Cysteine; Glutathione; Humans; T-Lymphocytes | 1993 |
Role of cysteine and glutathione in HIV infection and cancer cachexia: therapeutic intervention with N-acetylcysteine.
Topics: Acetylcysteine; Amino Acids; Cachexia; Cysteine; Glutathione; HIV Infections; Humans; Muscle, Skeletal; Neoplasms | 1997 |
Renal drug metabolism.
Topics: Acetylation; Acetylcysteine; Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Biotransformation; Carboxylic Ester Hydrolases; Cysteine; Cytochrome P-450 Enzyme System; Deamination; Glutamine; Glutathione; Glycine; Humans; Kidney; Methylation; Monoamine Oxidase; Oxidation-Reduction; Pharmaceutical Preparations; Pharmacokinetics | 1998 |
[Microequilibrium of drug molecules].
Topics: Acetylcysteine; Cysteine; Kinetics; Microchemistry; Models, Chemical; Pharmaceutical Preparations | 1999 |
Cysteine and glutathione in catabolic conditions and immunological dysfunction.
Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Humans; Immune System Diseases | 1999 |
Modulation of endogenous glutathione availability.
Topics: Acetylcysteine; Animals; Cysteine; Glutamine; Glutathione; Humans; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
N-acetyl-cysteine in the therapy of HIV-positive patients.
Topics: Acetylcysteine; Biological Availability; Cysteine; Glutathione; HIV Seropositivity; Humans; Sulfur | 1999 |
Glutathione and immune function.
Topics: Acetylcysteine; Cysteine; Glutathione; HIV Infections; Humans; Immunity; Lymphocytes | 2000 |
Acetylcysteine for prevention of contrast nephropathy: meta-analysis.
Topics: Acetylcysteine; Acute Kidney Injury; Aged; Contrast Media; Cysteine; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Outcome Assessment, Health Care; Radiography; Randomized Controlled Trials as Topic | 2003 |
Intracellular thiol concentration modulating inflammatory response: influence on the regulation of cell functions through cysteine prodrug approach.
Topics: Acetylcysteine; Acute-Phase Proteins; Animals; Cell Cycle; Cysteine; Cytokines; Glutathione; Humans; Inflammation; Prodrugs; Sulfhydryl Compounds; Thiazoles | 2003 |
Antioxidant effects of sulfur-containing amino acids.
Topics: Acetylcysteine; Amino Acids, Sulfur; Antioxidants; Cysteine; Glutathione; Methionine; Structure-Activity Relationship; Taurine; Thioctic Acid; Tiopronin | 2004 |
Yeast as a biosensor for antioxidants: simple growth tests employing a Saccharomyces cerevisiae mutant defective in superoxide dismutase.
Topics: Acetylcysteine; Air; Antioxidants; Atmosphere; Biosensing Techniques; Cysteine; Lysine; Methionine; Mutation; Saccharomyces cerevisiae; Superoxide Dismutase | 2005 |
Antioxidants as novel agents for asthma.
Topics: Acetylcysteine; Anti-Asthmatic Agents; Antioxidants; Asthma; Cysteine; Glutathione; Humans; Oxidative Stress; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2006 |
Cysteine, cystine or N-acetylcysteine supplementation in parenterally fed neonates.
Topics: Acetylcysteine; Cysteine; Cystine; Dietary Supplements; Humans; Infant, Newborn; Infant, Premature; Parenteral Nutrition; Randomized Controlled Trials as Topic | 2006 |
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Controlled Clinical Trials as Topic; Cysteine; Cystic Fibrosis; Free Radical Scavengers; Glutathione; HIV Infections; Humans; Prodrugs; Quality of Life | 2007 |
Role of reactive metabolites in the circulation in extrahepatic toxicity.
Topics: Acetylcysteine; Cysteine; Humans; Kidney; Liver; Trichloroethylene | 2012 |
Cysteine Network (CYSTEINET) Dysregulation in Parkinson's Disease: Role of N-acetylcysteine.
Topics: Acetylcysteine; Aging; Amino Acid Transport System y+; Brain; Cysteine; Energy Metabolism; Glutathione; Homeostasis; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Parkinson Disease; Protein Processing, Post-Translational; Reactive Oxygen Species | 2016 |
Potential Nutrients for Preventing or Treating Bronchopulmonary Dysplasia.
Topics: Acetylcysteine; Antioxidants; Arginine; Bronchopulmonary Dysplasia; Citrulline; Cysteine; Fatty Acids, Unsaturated; Glutamine; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Infant, Premature; Inositol; Selenium; Vitamin A; Vitamin B Complex | 2017 |
Cysteinet Dysregulation in Muscular Dystrophies: A Pathogenic Network Susceptible to Therapy.
Topics: Acetylcysteine; Animals; Cysteine; Humans; Muscular Dystrophies | 2017 |
Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease.
Topics: Acetylcysteine; Acetyltransferases; Cysteine; Diabetic Nephropathies; Humans; Kidney Tubules, Proximal; Leukotrienes; Oxidative Stress | 2019 |
N-acetyl-cysteine in Schizophrenia: Potential Role on the Sensitive Cysteine Proteome.
Topics: Acetylcysteine; Antioxidants; Cysteine; Glutathione; Humans; Oxidation-Reduction; Proteome; Schizophrenia | 2020 |
22 trial(s) available for acetylcysteine and cysteine
| Article | Year |
|---|---|
Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial.
Topics: Acetylcysteine; Adult; Aged; Antiviral Agents; CD4 Lymphocyte Count; Cysteine; Double-Blind Method; Female; Free Radical Scavengers; HIV Infections; HIV-1; Humans; Male; Middle Aged; Neutrophils; Nitroblue Tetrazolium; Superoxides; Tumor Necrosis Factor-alpha | 1996 |
A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group.
Topics: Acetylcysteine; Adult; Antioxidants; Bilirubin; Bronchoalveolar Lavage Fluid; Cardiac Output; Cysteine; Double-Blind Method; Free Radical Scavengers; Glutathione; Humans; Middle Aged; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiration, Artificial; Respiratory Distress Syndrome; Thiazoles; Thiazolidines; Time Factors | 1997 |
N-acetylcysteine treatment and the risk of toxic reactions to trimethoprim-sulphamethoxazole in primary Pneumocystis carinii prophylaxis in HIV-infected patients.
Topics: Acetylcysteine; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Cysteine; Exanthema; Female; Fever; Glutathione; Humans; Male; Pneumocystis; Pneumonia, Pneumocystis; Trimethoprim, Sulfamethoxazole Drug Combination | 1997 |
Time course of total cysteine, glutathione and homocysteine in plasma of patients with chronic hepatitis C treated with interferon-alpha with and without supplementation with N-acetylcysteine.
Topics: Acetylcysteine; Adult; Antiviral Agents; Cysteine; Double-Blind Method; Female; Glutathione; Hepatitis C, Chronic; Homocysteine; Humans; Interferon-alpha; Male; Time Factors | 1998 |
Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.
Topics: Acetylation; Acetylcysteine; Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cysteine; Elective Surgical Procedures; Ethers; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Hydrocarbons, Fluorinated; Inactivation, Metabolic; Male; Methyl Ethers; Middle Aged; Propionates; Rats; Sevoflurane | 1999 |
Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants.
Topics: Acetylcysteine; Age Factors; Antioxidants; Cysteine; Female; Free Radical Scavengers; Humans; Infant, Newborn; Infant, Premature; Infusions, Intravenous; Male | 1999 |
Virological and immunological effects of antioxidant treatment in patients with HIV infection.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Adult; Antioxidants; Antiviral Agents; Apoptosis; Ascorbic Acid; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Cell Division; Cysteine; Dipeptides; Drug Therapy, Combination; Glutathione; Humans; Interleukin-10; Lipopolysaccharide Receptors; Male; Middle Aged; Monocytes; Neopterin; Oxidative Stress; Pilot Projects; Receptors, Tumor Necrosis Factor; Solubility; Tumor Necrosis Factor-alpha | 2000 |
N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans.
Topics: Acetylcysteine; Acid-Base Equilibrium; Adult; Cross-Over Studies; Cysteine; Cystine; Double-Blind Method; Electrolytes; Exercise; Fatigue; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Humans; Infusions, Intravenous; Male; Osmolar Concentration; Physical Endurance; Potassium; Time Factors | 2003 |
N-Acetylcysteine improves the disturbed thiol redox balance after methionine loading.
Topics: Acetylcysteine; Adult; Antioxidants; Cross-Over Studies; Cysteine; Female; Homocysteine; Humans; Lipid Peroxidation; Male; Methionine; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sulfhydryl Compounds | 2003 |
Urinary and plasma homocysteine and cysteine levels during prolonged oral N-acetylcysteine therapy.
Topics: Acetylcysteine; Administration, Oral; Adult; Chromatography, High Pressure Liquid; Cysteine; Dose-Response Relationship, Drug; Expectorants; Female; Homocysteine; Humans; Male; Middle Aged | 2003 |
Effect of thiol antioxidant on body fat and insulin reactivity.
Topics: Acetylcysteine; Adipose Tissue; Adult; Antioxidants; Body Weight; Cell Line; Creatine; Cysteine; Cystine; Female; Glucose Tolerance Test; Humans; Hyperlipidemias; Insulin; Male; Middle Aged; Obesity; Receptor, Insulin; Sulfhydryl Compounds | 2004 |
N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals.
Topics: Acetylcysteine; Adult; Biological Availability; Cross-Over Studies; Cysteine; Double-Blind Method; Exercise Test; Glutathione; Humans; Infusions, Intravenous; Male; Muscle Fatigue; Muscle, Skeletal; Physical Endurance; Physical Exertion; Physical Fitness | 2004 |
Pharmacokinetics of N-acetylcysteine following repeated intravenous infusion in haemodialysed patients.
Topics: Acetylcysteine; Aged; Antioxidants; Area Under Curve; Blood Urea Nitrogen; Cysteine; Drug Administration Schedule; Expectorants; Female; Glutathione; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Pilot Projects; Renal Dialysis | 2005 |
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.
Topics: Acetylcysteine; Adult; Arginine; Blood Flow Velocity; Brachial Artery; Cross-Over Studies; Cystathionine; Cysteine; Dipeptides; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kinetics; Male; Methionine; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vasodilation | 2005 |
Effect of N-acetyl-L-cysteine on lymphocyte apoptosis, lymphocyte viability, TNF-alpha and IL-8 in HIV-infected patients undergoing anti-retroviral treatment.
Topics: Acetylcysteine; Administration, Oral; Adult; Anti-HIV Agents; Apoptosis; CD4 Lymphocyte Count; Cysteine; Double-Blind Method; Glutathione; HIV Infections; Humans; Interleukin-8; Lymphocytes; Middle Aged; Time Factors; Tumor Necrosis Factor-alpha; Viral Load | 2004 |
Gentamicin-induced ototoxicity in hemodialysis patients is ameliorated by N-acetylcysteine.
Topics: Acetylcysteine; Administration, Oral; Aged; Aminoglycosides; Anti-Bacterial Agents; Antioxidants; Bacteremia; Cysteine; Female; Gentamicins; Glutathione; Hearing Loss; Humans; Kidney Failure, Chronic; Male; Middle Aged; Oxidative Stress; Prospective Studies; Renal Dialysis | 2007 |
N-Acetylcysteine infusion does not affect glucose disposal during prolonged moderate-intensity exercise in humans.
Topics: Acetylcysteine; Adult; AMP-Activated Protein Kinase Kinases; Anaerobic Threshold; Cross-Over Studies; Cysteine; Cystine; Double-Blind Method; Exercise; Exercise Test; Fatty Acids, Nonesterified; Free Radical Scavengers; Glucose; Glutathione; Heart Rate; Humans; Infusions, Intravenous; Lactic Acid; Male; Muscle, Skeletal; Protein Kinases; Reactive Oxygen Species; Signal Transduction; Young Adult | 2010 |
N-acetylcysteine in handgrip exercise: plasma thiols and adverse reactions.
Topics: Acetylcysteine; Adult; Athletic Performance; Cross-Over Studies; Cysteine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glutathione; Hand Strength; Humans; Male; Middle Aged; Sulfhydryl Compounds; Young Adult | 2011 |
Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status.
Topics: Acetylcysteine; Administration, Oral; Adult; Antihypertensive Agents; Antioxidants; Biotransformation; Cholesterol; Cysteine; Double-Blind Method; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypertension; Leukocytes, Mononuclear; Male; Middle Aged; Smoking; Triglycerides | 2015 |
Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Area Under Curve; Biotransformation; Cysteine; Female; Gestational Age; Glucuronides; Glutathione; Humans; Infant, Extremely Premature; Infant, Newborn; Infusions, Intravenous; Male; Netherlands; Sulfates | 2017 |
Comparative effects of acute-methionine loading on the plasma sulfur-amino acids in NAC-supplemented HIV+ patients and healthy controls.
Topics: Acetylcysteine; Adult; Antiretroviral Therapy, Highly Active; Cysteine; Dietary Supplements; Female; Glutathione; HIV Infections; HIV-1; Humans; Male; Methionine; Middle Aged | 2018 |
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators.
Topics: Acetylcysteine; Cysteine; Glutathione; Humans; Metabolomics; NAD; Niacinamide | 2023 |
502 other study(ies) available for acetylcysteine and cysteine
| Article | Year |
|---|---|
Mercaptoimidazolylpropionic acid hydrobromide. Inhibition of tadpole collagenase and related properties.
Topics: Animals; Anura; Bacillus subtilis; Chemical Phenomena; Chemistry; Histidine; In Vitro Techniques; Larva; Magnetic Resonance Spectroscopy; Microbial Collagenase; Mutagens; Oxidation-Reduction; Rana catesbeiana; Sulfhydryl Compounds | 1978 |
2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde.
Topics: Acetaldehyde; Acetylation; Animals; Ethanol; Inactivation, Metabolic; Male; Methods; Penicillamine; Radioisotope Dilution Technique; Rats; Stereoisomerism; Thiazoles | 1978 |
Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cysteine; Magnetic Resonance Spectroscopy; Mice; Thiazoles | 1982 |
Equilibrium and kinetics studies of transnitrosation between S-nitrosothiols and thiols.
Topics: Kinetics; Mercaptoethanol; Nitrosation; Nitroso Compounds; Penicillamine; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Thermodynamics | 2001 |
The metabolism of benzyl isothiocyanate and its cysteine conjugate.
Topics: Acetylcysteine; Animals; Benzyl Compounds; Cysteine; Dogs; Glutathione; Hydrogen-Ion Concentration; Kidney; Liver; Rats; Thiocyanates | 1977 |
[Drug therapy of external eye injuries caused by chemical substances].
Topics: Acetylcysteine; Burns, Chemical; Cysteine; Eye Burns; Humans; Microbial Collagenase | 1979 |
Oxidizing action of purine N-oxide esters.
Topics: Acetylation; Acetylcysteine; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Cyclic N-Oxides; Cysteine; Esters; Guanine; Hydrogen-Ion Concentration; Iodides; Iodine; Mercaptopurine; Methionine; Oxidation-Reduction; Purines; Pyridines; Sulfates; Sulfhydryl Compounds; Tryptophan; Tyrosine; Uric Acid; Xanthines | 1975 |
Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes.
Topics: Acetylcysteine; Animals; Biotransformation; Bromobenzenes; Cysteine; Glutathione; In Vitro Techniques; Kinetics; Liver; Male; Maleates; Methionine; Microsomes, Liver; Phenobarbital; Rats | 1979 |
The biosynthesis of 3-hydroxypropylmercapturic acid from cyclophosphamide.
Topics: Acetylcysteine; Acrolein; Animals; Bile; Chromatography, Paper; Cyclophosphamide; Cysteine; Glutathione; Liver; Rats | 1979 |
Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis.
Topics: Acetylcysteine; Animals; Cysteine; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Male; Peptide Hydrolases; Rats; Substrate Specificity; Tissue Distribution | 1978 |
Chemical and biological characterization of different Tc complexes of cysteine and cysteine derivatives.
Topics: Acetylcysteine; Animals; Cysteine; Isotope Labeling; Male; Penicillamine; Rats; Technetium; Tissue Distribution | 1978 |
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glucuronates; Glutathione; In Vitro Techniques; Liver; Male; Mice; Phenobarbital; Rats; Sulfates; Time Factors | 1978 |
Acetaminophen kinetics in acutely poisoned patients.
Topics: Acetaminophen; Acetylcysteine; Adult; Computers; Cysteine; Glucuronates; Humans; Kinetics; Models, Biological; Oxidation-Reduction; Sulfates | 1979 |
Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.
Topics: Acetaminophen; Acetylcysteine; Cell-Free System; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Microsomes, Liver | 1977 |
Mercapturic acid formation in the developing rat.
Topics: Acetylcysteine; Aging; Animals; Cysteine; Female; Glutathione Transferase; Liver; Male; Propane; Rats; Sulfoxides | 1977 |
Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glucuronates; Humans; Liver Diseases; Male; Suicide; Sulfates | 1976 |
Mechanism of the protective action of cysteine and penicillamine against acetaldehyde-induced mitochondrial injury.
Topics: Acetaldehyde; Acetylcysteine; Animals; Carbon Dioxide; Cysteine; In Vitro Techniques; Mitochondria, Liver; Oxygen Consumption; Penicillamine; Rats; Structure-Activity Relationship; Time Factors | 1976 |
Replacement of a chlorine with a methylsulfonyl group in the metabolism of propachlor (2-chloro-N-isopropylacetanilide).
Topics: Acetamides; Acetanilides; Acetylcysteine; Animals; Chlorine; Cysteine; Female; Rats; Sheep; Sulfones | 1976 |
[Thermal decomposition of cysteine, cystine, N-acetylcysteine, 4-thiazolidinecarboxylic acid and cysteine methyl ester in soy bean oil (authors transl)].
Topics: Acetylcysteine; Antioxidants; Carboxylic Acids; Cysteine; Cystine; Drug Stability; Esters; Glycine max; Hot Temperature; Oils; Thiazoles | 1976 |
Isolation and identification of paracetamol metabolites.
Topics: Acetaminophen; Acetylcysteine; Cysteine; Glucuronates; Humans; Sulfates | 1976 |
Metabolism of paracetamol after therapeutic and hepatotoxic doses in man.
Topics: Acetaminophen; Acetylcysteine; Cysteine; Glucuronates; Humans; Liver; Sulfates | 1976 |
Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds.
Topics: Acetylcysteine; Amino Acids; Antifungal Agents; Aspergillus; Copper; Cysteamine; Cysteine; Drug Antagonism; Glutathione; Organometallic Compounds; Quinolines | 1975 |
An extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning. I. In vitro studies of the effects of four complexing agents on the distribution and dialyzability of methylmercury in human blood.
Topics: Acetates; Acetylcysteine; Blood Proteins; Cysteine; Humans; In Vitro Techniques; Mercury Isotopes; Mercury Poisoning; Methylmercury Compounds; Penicillamine; Protein Binding; Radioisotopes; Renal Dialysis; Sulfhydryl Reagents; Time Factors | 1975 |
Mucodyne as an expectorant.
Topics: Acetylcysteine; Asthma; Bromhexine; Bronchitis; Cysteine; Expectorants; Humans | 1975 |
Protective action of ascorbic acid and sulfur compounds against acetaldehyde toxicity: implications in alcoholism and smoking.
Topics: Acetaldehyde; Acetylcysteine; Alcoholism; Anesthetics; Animals; Ascorbic Acid; Cysteine; Humans; Lethal Dose 50; Male; Rats; Smoking; Sulfur; Thiamine | 1975 |
Deactivation of cyclophosphamide (NSC-26271) metabolites by sulfhydryl compounds.
Topics: Acetylcysteine; Alkylation; Chemical Phenomena; Chemistry; Cyclophosphamide; Cysteine; Glutathione; In Vitro Techniques; Inactivation, Metabolic; Kinetics; Sulfhydryl Compounds | 1976 |
Beneficial effects of N-acetylcysteine and cysteine in stunned myocardium in perfused rat heart.
Topics: Acetylcysteine; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cystamine; Cysteine; Female; Hydroxyl Radical; Male; Myocardial Stunning; Perfusion; Rats; Rats, Wistar; Superoxides | 1991 |
Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine.
Topics: Acetylcysteine; Administration, Oral; Cysteine; Glutathione; HIV Infections; Humans; Leukocytes, Mononuclear; Male | 1992 |
Modulation of transforming growth factor-beta 1 antiproliferative effects on endothelial cells by cysteine, cystine, and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Cattle; Cell Division; Cells, Cultured; Cysteine; Cystine; Endothelium, Vascular; Glutathione; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Impairment of cysteine synthesis from methionine in rats exposed to surgical stress.
Topics: Acetylcysteine; Animals; Body Weight; Cells, Cultured; Cystathionine gamma-Lyase; Cysteine; Eating; Liver; Male; Methionine; Rats; Rats, Wistar; Stress, Physiological; Surgical Procedures, Operative | 1992 |
Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine.
Topics: Acetylcysteine; Amino Acids; Animals; Biological Transport; Cattle; Cells, Cultured; Cysteine; Cystine; Endothelium, Vascular; Glutathione; Oxidation-Reduction; Pulmonary Artery | 1992 |
Comparative metabolism of the cysteine and homocysteine conjugates of propachlor by in situ perfused kidneys of rats.
Topics: Acetanilides; Acetylcysteine; Animals; Chemotherapy, Cancer, Regional Perfusion; Cysteine; Gas Chromatography-Mass Spectrometry; Herbicides; Homocysteine; Kidney; Rats; Rats, Inbred Strains | 1992 |
Attenuation of immunologic reactivity of lipoprotein(a) by thiols and cysteine-containing compounds. Structural implications.
Topics: Acetylcysteine; Apolipoproteins A; Apolipoproteins B; Blotting, Western; Cysteine; Dithiothreitol; Enzyme-Linked Immunosorbent Assay; Homocysteine; Humans; Lipoprotein(a); Lipoproteins; Male; Mercaptoethanol; Molecular Structure; Sulfhydryl Compounds | 1992 |
Stereospecific glutathione conjugation of (R)- and (S)-2-bromoisovalerylurea in freshly isolated rat kidney proximal tubular cells.
Topics: Acetylcysteine; Animals; Bromisovalum; Cells, Cultured; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Kidney Tubules, Proximal; Male; Molecular Conformation; Rats; Rats, Inbred Strains; Stereoisomerism | 1992 |
Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney.
Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Body Weight; Cysteine; Cystine; Dose-Response Relationship, Drug; Glutathione; Kidney; Male; Mice; Mice, Inbred C57BL; Organ Size | 1992 |
Inhibition of interleukin-1 (IL-1) induced neutral proteases from rabbit articular chondrocytes by WY-46,135 and WY-48,989.
Topics: Acetylcysteine; Animals; Benzothiazoles; Cartilage, Articular; Cysteine; Endopeptidases; Enzyme Induction; Hindlimb; In Vitro Techniques; Interleukin-1; Male; Microbial Collagenase; Protease Inhibitors; Pyrazoles; Rabbits | 1991 |
Protection by cysteine esters against chemically induced pulmonary oedema.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cysteine; Cystine; DNA; Female; Fluorocarbons; Glutathione; Liver; Lung; Methionine Sulfoximine; Perfusion; Pulmonary Edema; Rats; Sulfhydryl Compounds; Time Factors | 1991 |
[Protective effects of SH-compounds on ischemia reperfusion induced arrhythmias in the isolated rat heart].
Topics: Acetylcysteine; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cysteamine; Cysteine; Dihydropyridines; Dimaprit; Female; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Rats; Rats, Inbred Strains; Thiourea | 1991 |
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Cysteine; Cytochrome P-450 Enzyme System; Hepatitis B; Humans; Liver Neoplasms; Middle Aged; Oxidation-Reduction; Reference Values | 1991 |
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Bronchoalveolar Lavage Fluid; Cysteine; Female; Glutathione; Humans; Male; Middle Aged | 1991 |
Lack of effect of N-acetylcysteine on the release of oxygen radicals from neutrophils and alveolar macrophages.
Topics: Acetylcysteine; Administration, Oral; Adult; Animals; Bronchoalveolar Lavage Fluid; Cysteine; Free Radicals; Glutathione; Humans; Macrophages; Neutrophils; Oxygen; Pulmonary Alveoli; Rats | 1991 |
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.
Topics: Acetylcysteine; Adenosine; Animals; Cattle; Cysteine; GTP-Binding Proteins; In Vitro Techniques; Methylation; Molecular Weight; Rod Cell Outer Segment; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Transducin | 1991 |
Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives.
Topics: Acetylcysteine; Animals; Base Sequence; Cell Line; Cysteine; Gene Expression Regulation; Gene Products, gag; Glutathione; HIV Antigens; HIV Core Protein p24; HIV-1; Humans; Molecular Sequence Data; Monocytes; NF-kappa B; T-Lymphocytes; Transcription, Genetic; Tumor Cells, Cultured; Viral Core Proteins; Virus Replication | 1991 |
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.
Topics: Acetylcysteine; Animals; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Stereoisomerism; Trichloroethylene | 1991 |
Biochemical and pharmacological interactions between nitroglycerin and thiols. Effects of thiol structure on nitric oxide generation and tolerance reversal.
Topics: Acetylcysteine; Animals; Aorta; Benzoates; Blood; Buffers; Culture Media; Culture Techniques; Cysteine; Drug Tolerance; Hot Temperature; Humans; Nitric Oxide; Nitroglycerin; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Thimerosal | 1991 |
Model systems for the evaluation of mucolytic drugs: acetylcysteine and S-carboxymethylcysteine.
Topics: Acetylcysteine; Animals; Carbocysteine; Chromatography, Gel; Cysteine; Elasticity; Expectorants; In Vitro Techniques; Male; Microscopy, Electron, Scanning; Models, Biological; Mucus; Rats; Rats, Inbred Strains; Swine; Swine, Miniature; Trachea; Viscosity | 1990 |
Glutathione catabolism by the ischemic rat kidney.
Topics: Acetylcysteine; Animals; Antimetabolites; Cysteine; gamma-Glutamyltransferase; Glutathione; Ischemia; Isoxazoles; Kidney; Male; Rats; Reperfusion; Sulfhydryl Compounds | 1990 |
Localization and capacity of the last step of mercapturic acid biosynthesis and the reabsorption and acetylation of cysteine S-conjugates in the rat kidney.
Topics: Acetylation; Acetylcysteine; Animals; Cysteine; Kidney; Male; Metabolic Clearance Rate; Perfusion; Rats; Rats, Inbred Strains | 1991 |
Determination of N-acetylcysteine in human plasma by gas chromatography-mass spectrometry.
Topics: Acetylcysteine; Autoanalysis; Cysteine; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Indicators and Reagents | 1991 |
Metabolism of L-cysteine S-conjugates and N-(trideuteroacetyl)-L-cysteine S-conjugates of four fluoroethylenes in the rat. Role of balance of deacetylation and acetylation in relation to the nephrotoxicity of mercapturic acids.
Topics: Acetylation; Acetylcysteine; Amidohydrolases; Animals; Arylamine N-Acetyltransferase; Bile; Chlorofluorocarbons; Cysteine; Deuterium; Ethylenes; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Kidney; Kidney Diseases; Liver; Male; Rats; Rats, Inbred Strains; Subcellular Fractions | 1991 |
Glutathione in human melanoma cells. Effects of cysteine, cysteine esters and glutathione isopropyl ester.
Topics: Acetylcysteine; Cysteine; Expectorants; Glutathione; Humans; Melanoma; Skin Neoplasms; Tumor Cells, Cultured | 1990 |
Detection of N-acetylcysteine, cysteine and their disulfides in urine by liquid chromatography with a dual-electrode amperometric detector.
Topics: Acetylcysteine; Chromatography, Liquid; Cysteine; Disulfides; Electrochemistry; Humans | 1990 |
Experimental studies on the acute cardiovascular toxicity of formalin and its antidotal treatment.
Topics: Acetylcysteine; Animals; Antidotes; Bicarbonates; Cysteine; Formaldehyde; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; Rats; Rats, Inbred Strains; Sodium; Sodium Bicarbonate | 1990 |
Elimination of 14C by calves, pigs and rats renally perfused with radiolabelled dichlorovinyl or acetamide substrates.
Topics: Acetanilides; Acetylation; Acetylcysteine; Animals; Carbon Radioisotopes; Cattle; Cysteine; Herbicides; Iodoacetamide; Kidney; Perfusion; Rats; Rats, Inbred Strains; Swine; Trichloroethylene | 1990 |
Mercapturic acid formation in cultured opossum kidney cells.
Topics: Acetylation; Acetylcysteine; Animals; Cells, Cultured; Cysteine; Extracellular Space; Intracellular Fluid; Kidney; Marsupialia; Models, Biological | 1990 |
Mechanism of formation of 6-amino-5-(N-methylformylamino)-1-methyluracil and 3,7-dimethyluric acid from theobromine in the rat in vitro: involvement of cytochrome P-450 and a cellular thiol.
Topics: Acetylcysteine; Animals; Cimetidine; Cysteine; Cytochrome P-450 Enzyme System; Dithiothreitol; Glutathione; Kinetics; Male; Metyrapone; Microsomes, Liver; Pyridines; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Theobromine; Uracil; Uric Acid | 1990 |
Acute acrylonitrile toxicity: studies on the mechanism of the antidotal effect of D- and L-cysteine and their N-acetyl derivatives in the rat.
Topics: Acetylcysteine; Acrylonitrile; Acute Disease; Animals; Antidotes; Cysteine; Drug Evaluation, Preclinical; Isomerism; Lethal Dose 50; Male; Nitriles; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1990 |
Sulfur amino acid metabolism in cystinuria: a biochemical and clinical study of patients.
Topics: Acetylcysteine; Adult; Amino Acids, Sulfur; Cysteine; Cystinuria; Female; Homozygote; Humans; Male; Penicillamine; Tiopronin | 1990 |
Primary culture of proximal tubular cells from normal rat kidney as an in vitro model to study mechanisms of nephrotoxicity. Toxicity of nephrotoxicants at low concentrations during prolonged exposure.
Topics: Acetylcysteine; Animals; Biological Transport; Cells, Cultured; Chlorofluorocarbons; Cysteine; Glutathione; Hydrocarbons, Halogenated; Kidney Tubules, Proximal; Male; Methylglucosides; Microscopy, Electron, Scanning; Models, Biological; Rats; Rats, Inbred Strains; Time Factors | 1990 |
A urinary cysteine-halothane metabolite: validation and measurement in children.
Topics: Acetylcysteine; Anesthesia, Inhalation; Biotransformation; Child; Chromatography, High Pressure Liquid; Cysteine; Halothane; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Trifluoroacetic Acid | 1990 |
[In vitro evaluation of mucolytic activities of some expectorants using porcine gastric mucin].
Topics: Acetylcysteine; Animals; Cysteine; Drug Evaluation, Preclinical; Expectorants; Gastric Mucins; Swine; Temperature; Time Factors; Viscosity | 1988 |
The use of mass spectrometry in the study of chemically-reactive drug metabolites. Application of MS/MS and LC/MS to the analysis of glutathione- and related S-linked conjugates of N-methylformamide.
Topics: Acetylcysteine; Animals; Bile; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cysteine; Formamides; Glutathione; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Spectrometry, Mass, Fast Atom Bombardment | 1989 |
N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans.
Topics: Acetylcysteine; Adult; Amino Acids, Essential; Biological Availability; Cysteine; Female; Humans; Infusions, Intravenous; Kidney; Male; Parenteral Nutrition, Total; Tyrosine | 1989 |
Oral N-acetylcysteine or S-carboxymethylcysteine inhibit cigarette smoke-induced hypersecretion of mucus in rat larynx and trachea in situ.
Topics: Acetylcysteine; Animals; Carbocysteine; Cysteine; Fucose; Hexoses; Larynx; Male; Mucus; Nicotiana; Plants, Toxic; Rats; Rats, Inbred Strains; Serum Albumin; Smoke; Specific Pathogen-Free Organisms; Trachea | 1989 |
Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Uptake of the conjugates and activation to toxic metabolites.
Topics: Acetylation; Acetylcysteine; Animals; Biological Transport; Chromatography, High Pressure Liquid; Cysteine; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Fluorinated; Inactivation, Metabolic; Kidney Tubules, Proximal; Male; Probenecid; Rats; Rats, Inbred Strains; Subcellular Fractions | 1989 |
Effect of thiols on lipid peroxidation in rat liver microsomes.
Topics: Acetylcysteine; Animals; Cysteamine; Cysteine; Dithiothreitol; Glutathione; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; Penicillamine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds | 1989 |
Effect of oral glutathione on hepatic glutathione levels in rats and mice.
Topics: Acetaminophen; Acetylcysteine; Adenosine Triphosphate; Animals; Cysteine; Fasting; Glutathione; Liver; Maleates; Methionine; Mice; Rats; Rats, Inbred Strains | 1989 |
Fast atom bombardment and tandem mass spectrometry for structure determination of cysteine, N-acetylcysteine, and glutathione adducts of xenobiotics.
Topics: Acetylcysteine; Chemical Phenomena; Chemistry; Cysteine; Glutathione; Mass Spectrometry; Molecular Structure; Xenobiotics | 1989 |
Molecular characterization of the cysJIH promoters of Salmonella typhimurium and Escherichia coli: regulation by cysB protein and N-acetyl-L-serine.
Topics: Acetylcysteine; Base Sequence; Cysteine; Enzyme Activation; Escherichia coli; Genes; Genes, Bacterial; Genes, Regulator; Genotype; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; Salmonella typhimurium; Sequence Homology, Nucleic Acid; Transcription, Genetic | 1989 |
Thallium (I) interactions in biological fluids: a potentiometric investigation of thallium(I) complex equilibria with some sulphur-containing amino acids.
Topics: Acetylcysteine; Amino Acids; Chemical Phenomena; Chemistry; Cysteine; Kinetics; Penicillamine; Potentiometry; Thallium | 1989 |
Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration.
Topics: Acetaminophen; Acetylcysteine; Adult; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Half-Life; Humans; Male; Sulfhydryl Compounds | 1989 |
Transport and activation of S-(1,2-dichlorovinyl)-L-cysteine and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine in rat kidney proximal tubules.
Topics: Acetylcysteine; Animals; Biological Transport; Biotransformation; Cysteine; Drug Interactions; In Vitro Techniques; Kidney Tubules, Proximal; Male; Probenecid; Rats; Rats, Inbred Strains; Sulfur Radioisotopes | 1989 |
Use of thermospray liquid chromatography-mass spectrometry for characterization of reactive metabolites of 3'-hydroxyacetanilide, a non-hepatotoxic regioisomer of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cysteine; Isomerism; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice | 1989 |
A sensitive method for the determination of urinary mercapturic acids for use in biological monitoring.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Electrochemistry; Environmental Monitoring; Male; Photometry; Rats; Rats, Inbred Strains | 1989 |
Inhibition of stress-induced gastric injury in the rat by glutathione.
Topics: Acetylcysteine; Animals; Coenzyme A; Cysteine; Gastric Mucosa; Glutathione; Liver; Male; Rats; Rats, Inbred Strains; Stress, Physiological; Sulfhydryl Compounds | 1989 |
Bioactivation of the cysteine-S-conjugate and mercapturic acid of tetrafluoroethylene to acylating reactive intermediates in the rat: dependence of activation and deactivation activities on acetyl coenzyme A availability.
Topics: Acetyl Coenzyme A; Acetylcysteine; Acylation; Animals; Biotransformation; Carbon-Sulfur Lyases; Cysteine; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Kidney; Liver; Lyases; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains; Subcellular Fractions; Time Factors | 1989 |
An ESR study of nonenzymatic reactions of nitroso compounds with biological reducing agents.
Topics: Acetylcysteine; Chemical Phenomena; Chemistry; Cysteine; Electron Spin Resonance Spectroscopy; Glutathione; NADP; Naphthalenesulfonates; Nitroso Compounds; Oxidation-Reduction | 1988 |
Mucolytic agents for glue ear.
Topics: Acetylcysteine; Carbocysteine; Child; Cysteine; Humans; Otitis Media; Otitis Media with Effusion; Viscosity | 1985 |
Mucolytic agents for glue ear.
Topics: Acetylcysteine; Administration, Oral; Carbocysteine; Child; Cysteine; Humans; In Vitro Techniques; Mucus; Otitis Media with Effusion | 1985 |
Metabolism and excretion of a glutathione conjugate of acetaminophen in the isolated perfused rat kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Kidney; Male; Metabolic Clearance Rate; Perfusion; Rats; Rats, Inbred F344 | 1986 |
[Thiol-dependent activation of guanylate cyclase by organic nitrates].
Topics: Acetylcysteine; Animals; Cysteine; Enzyme Activation; Glutathione; Guanylate Cyclase; In Vitro Techniques; Liver; Nitrates; Rats; Structure-Activity Relationship; Sulfhydryl Compounds | 1986 |
Mutagenicity of amino acid and glutathione S-conjugates in the Ames test.
Topics: Acetylcysteine; Animals; Carbon-Sulfur Lyases; Cysteine; gamma-Glutamyltransferase; Glutathione; Homocysteine; Kidney; Liver; Lyases; Rats; Salmonella typhimurium; Structure-Activity Relationship | 1988 |
A novel inhibitor of mammalian collagenase.
Topics: Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzothiazoles; Cell Line; Clostridium; Cysteine; Fibroblasts; Humans; Kinetics; Microbial Collagenase; Protease Inhibitors; Rats; Skin; Substrate Specificity; Tail; Tendons; Thermolysin; Trypsin | 1985 |
The generation and subsequent fate of glutathionyl radicals in biological systems.
Topics: Acetaminophen; Acetylcysteine; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Glutathione Disulfide; Horseradish Peroxidase; Nitrogen; Oxygen; Phenetidine; Spin Labels | 1985 |
Oxidation of thiol drugs and biochemicals by the lactoperoxidase/hydrogen peroxide system.
Topics: Acetylcysteine; Captopril; Cysteamine; Cysteine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Hydrogen Peroxide; Lactoperoxidase; Oxygen Consumption; Penicillamine; Peroxidases; Sulfhydryl Compounds | 1987 |
Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cobalt.
Topics: Acetylcysteine; Animals; Chelating Agents; Cobalt; Cysteine; Edetic Acid; Glutathione; Male; Mice; Pentetic Acid; Tissue Distribution | 1986 |
Metabolism of 2,3,4',6-tetrachlorobiphenyl: formation and tissue localization of mercapturic acid pathway metabolites in mice.
Topics: Acetylcysteine; Adipose Tissue; Animals; Binding Sites; Cysteine; Female; Kidney; Liver; Lung; Mice; Polychlorinated Biphenyls; Tissue Distribution | 1987 |
Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron.
Topics: Acetylcysteine; Benzoates; Biological Products; Cysteine; Hemoglobins; Iron; Luminescent Measurements; Nitric Oxide; Nitroglycerin; Nitroprusside; Sulfhydryl Compounds; Thimerosal; Vasodilator Agents | 1987 |
[Cysteine in parenteral nutrition: comparative study of N-acetyl-cysteine and N,N-diacetylcystine in the rat model].
Topics: Acetylcysteine; Animals; Cysteine; Cystine; Liver; Male; Parenteral Nutrition, Total; Rats; Rats, Inbred Strains | 1988 |
The effect of sodium-2-mercaptoethane-sulphonate, N-acetylcysteine and cysteine on the uptake of cytosine arabinoside by normal and neoplastic thymus cells of mice.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine; Cytarabine; Female; Male; Mercaptoethanol; Mesna; Mice; Thymus Gland; Thymus Neoplasms; Tumor Cells, Cultured | 1988 |
Immunohistochemical localization of glutamine transaminase K, a rat kidney cysteine conjugate beta-lyase, and the relationship to the segment specificity of cysteine conjugate nephrotoxicity.
Topics: Acetylcysteine; Animals; Antibody Specificity; Cysteine; Immunohistochemistry; Kidney; Lyases; Rats; Transaminases | 1988 |
Determination of specific urinary thioethers derived from acrylonitrile and ethylene oxide.
Topics: Acetylcysteine; Acrylonitrile; Animals; Cysteine; Environmental Monitoring; Ethylene Oxide; Nitriles; Rats; Rats, Inbred Strains | 1988 |
Nephrotoxicity of mercapturic acids of three structurally related 2,2-difluoroethylenes in the rat. Indications for different bioactivation mechanisms.
Topics: Acetylcysteine; Animals; Biotransformation; Cysteine; Dose-Response Relationship, Drug; Fluoroacetates; Glycosuria; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Kidney Diseases; Organ Size; Proteinuria; Pyruvates; Pyruvic Acid; Rats; Structure-Activity Relationship; Urea | 1988 |
Identification of S-(2,5-dihydroxyphenyl)-cysteine and S-(2,5-dihydroxyphenyl)-N-acetyl-cysteine as urinary metabolites of acetaminophen in the mouse. Evidence for p-benzoquinone as a reactive intermediate in acetaminophen metabolism.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, High Pressure Liquid; Cysteine; Hydroquinones; Male; Mice; Mice, Inbred BALB C; Quinones | 1988 |
Determination of cysteine, glutathione and N-acetylcysteine in plasma by ion-pair reversed-phase liquid chromatography and post-column derivatization.
Topics: Acetylcysteine; Cysteine; Glutathione; Half-Life; Humans; Indicators and Reagents | 1988 |
Application of thermospray/high-performance liquid chromatography/mass spectrometry to the identification of glutathione conjugates derived from bioactive epoxides.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine; Cytosol; Epoxy Compounds; Ethers, Cyclic; Glutathione; In Vitro Techniques; Indicators and Reagents; Liver; Male; Mass Spectrometry; Rats; Rats, Inbred Strains; Subcellular Fractions | 1988 |
Applications of fast atom bombardment and tandem mass spectrometry.
Topics: Acetylcysteine; Carcinogens; Cysteine; Glutathione; Mass Spectrometry; Oligonucleotides; Peptides; Toxins, Biological | 1988 |
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds | 1988 |
The use of 1H spin echo NMR and HPLC to confirm doxorubicin induced depletion of glutathione in the intact HeLa cell.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; HeLa Cells; Humans; Lactates; Magnetic Resonance Spectroscopy | 1988 |
Unusual conjugates in biological profiles originating from consumption of onions and garlic.
Topics: Acetylcysteine; Allium; Cysteine; Diet; Garlic; Gas Chromatography-Mass Spectrometry; Hippurates; Humans; Peptides; Plants, Medicinal | 1987 |
Cysteine analogues potentiate glucose-induced insulin release in vitro.
Topics: Acetylcysteine; Animals; Cysteamine; Cysteine; Dose-Response Relationship, Drug; Female; Glucose; Glutathione; Insulin; Insulin Secretion; Islets of Langerhans; Male; Penicillamine; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Inter-subject and ethnic differences in paracetamol metabolism.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Black People; Cysteine; Ethanol; Female; Ghana; Glucuronates; Humans; Kenya; Male; Scotland; Sex Characteristics; Smoking; Sulfates; White People | 1986 |
Effect of sulfur amino acid supplementation of raw soy flour on the growth and pancreatic weights of rats.
Topics: Acetylcysteine; Amino Acids, Sulfur; Animals; Body Weight; Cysteine; Cystine; Dietary Proteins; Male; Methionine; Nutritive Value; Organ Size; Pancreas; Plant Proteins, Dietary; Rats; Rats, Inbred Strains; Soybean Proteins | 1987 |
Inter-organ metabolism and transport of a cysteine-S-conjugate of xenobiotics in normal and mutant analbuminemic rats.
Topics: Acetylation; Acetylcysteine; Animals; Arylamine N-Acetyltransferase; Blood Proteins; Cysteine; Intestine, Small; Kidney; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Serum Albumin | 1987 |
External GSSG enhances intracellular glutathione level in isolated cardiac myocytes.
Topics: Acetylcysteine; Animals; Carmustine; Cysteine; Glucose; Glutathione; Heart; Kinetics; Maleates; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1987 |
Transport of N-acetyl-S-pentachloro-1,3-butadienylcysteine by rat renal cortex.
Topics: Acetylcysteine; Animals; Antimetabolites; Biological Transport, Active; Butadienes; Cysteine; Female; Kidney Cortex; Kinetics; Rats; Rats, Inbred Strains; Temperature | 1986 |
Mercapturic acid formation in the marmoset (Callithrix jacchus).
Topics: Acetylation; Acetylcysteine; Animals; Benzyl Compounds; Callithrix; Carbon Radioisotopes; Cysteine; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells.
Topics: Acetylcysteine; Aminooxyacetic Acid; Animals; Carbon-Sulfur Lyases; Cell Line; Cell Survival; Cysteine; Glutathione; Isoxazoles; Kidney Tubules, Proximal; Lyases; Microscopy, Electron; Pyruvates; Pyruvic Acid; Structure-Activity Relationship; Swine | 1986 |
Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates.
Topics: Acetylcysteine; Animals; Butadienes; Cysteine; Female; Glutathione; Kidney Diseases; Kidney Medulla; Kidney Tubules, Proximal; Male; Necrosis; Rats; Sex Factors; Urea | 1986 |
Zinc intestinal absorption in rats: specificity of amino acids as ligands.
Topics: Acetylcysteine; Amino Acids; Animals; Colon; Cysteine; Histidine; Ileum; Imidazoles; Indoles; Intestinal Absorption; Jejunum; Kinetics; Male; Proline; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Tryptophan; Zinc | 1986 |
alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. I. (Bio-) synthesis, analysis and identification of diastereomeric glutathione conjugates and mercapturates.
Topics: Acetylcysteine; Animals; Bile; Bromisovalum; Chromatography, High Pressure Liquid; Cysteine; Cytosol; Glutathione; Kinetics; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Rats; Stereoisomerism; Urea | 1986 |
Nutritional improvement of legume proteins through disulfide interchange.
Topics: Acetylcysteine; Chymotrypsin; Cysteine; Disulfides; Flour; Glycine max; Humans; Nutritional Physiological Phenomena; Plant Proteins, Dietary; Soybean Proteins; Trypsin; Trypsin Inhibitors | 1986 |
No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid.
Topics: Acetylcysteine; Administration, Oral; Adult; Cysteine; Female; Glutathione; Humans; Male; Pulmonary Alveoli; Therapeutic Irrigation | 1987 |
The fate of 4-cyano-N,N-dimethylaniline in mice: the occurrence of a novel metabolite during N-demethylation of an aromatic amine.
Topics: Acetylcysteine; Aniline Compounds; Animals; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cysteine; Male; Mice; Rats; Species Specificity; Tissue Distribution | 1985 |
Protective action of sulfur compounds against aldehyde toxicants of cigarette smoke.
Topics: Acetaldehyde; Acetylcysteine; Acrolein; Aldehydes; Animals; Cysteine; Formaldehyde; Lethal Dose 50; Male; Nicotiana; Plants, Toxic; Rats; Respiratory System; Smoke; Sulfur | 1985 |
The mercapturic acid pathway metabolites of a glutathione conjugate of aflatoxin B1.
Topics: Acetylcysteine; Aflatoxin B1; Aflatoxins; Animals; Chromatography, High Pressure Liquid; Cysteine; Dipeptidases; Dipeptides; Glutathione; Kidney; Male; Rats; Rats, Inbred F344; Swine | 1985 |
Inhibition of rat liver glutathione S-transferases by glutathione conjugates and corresponding L-cysteines and mercapturic acids.
Topics: Acetylcysteine; Animals; Cysteine; Cytosol; Female; Glutathione; Glutathione Transferase; In Vitro Techniques; Isoenzymes; Liver; Male; Rats; Rats, Inbred Strains | 1986 |
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteine; Glucuronates; Glucuronic Acid; Glutathione; Kinetics; Liver; Liver Glycogen; Male; Mice; Phosphoadenosine Phosphosulfate; Protein Binding; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1986 |
Studies of possible acrylonitrile poisoning antidote.
Topics: Acetylcysteine; Acrylonitrile; Animals; Antidotes; Cysteine; Humans; Nitriles; Sodium Nitrite; Thiosulfates | 1985 |
The metabolism of crotyl phosphate, crotyl alcohol and crotonaldehyde.
Topics: Acetylcysteine; Alcohols; Aldehydes; Animals; Butanols; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Paper; Cysteine; Esters; Glutathione; Hydrolysis; Liver; Male; Maleates; NAD; Organophosphorus Compounds; Oxidation-Reduction; Rats | 1971 |
Corneal toxicity of collagenase inhibitors.
Topics: Acetylcysteine; Animals; Calcium; Cornea; Corneal Opacity; Cysteine; Edema; Edetic Acid; Hypertonic Solutions; Injections; Microbial Collagenase; Ophthalmic Solutions; Rabbits; Sodium; Sodium Chloride | 1973 |
Some metabolites of S-pentyl-L-cysteine in the rabbit and other species.
Topics: Acetylcysteine; Animals; Chromatography, Gas; Chromatography, Paper; Columbidae; Cricetinae; Cysteine; Electrophoresis, Paper; Feces; Female; Guinea Pigs; Kidney; Lactates; Liver; Mice; Organ Specificity; Pyruvates; Rabbits; Rats; Species Specificity; Sulfides | 1973 |
Amelioration of cyclophosphamide-induced cystitis.
Topics: Acetylcysteine; Animals; Chromatography, Thin Layer; Cyclophosphamide; Cysteine; Cystitis; Dogs; Female; Half-Life; Haplorhini; Sulfur Isotopes; Urinary Bladder; Urinary Catheterization | 1971 |
In vitro and in vivo inactivation of reagins with mercaptans.
Topics: Acetylcysteine; Animals; Antigen-Antibody Complex; Cysteamine; Cysteine; Desensitization, Immunologic; Haplorhini; Humans; Immunoglobulin E; Macaca; Mercaptoethanol; Passive Cutaneous Anaphylaxis; Penicillamine; Rhinitis, Allergic, Seasonal; Sulfhydryl Compounds | 1971 |
The metabolic formation of mercapturic acids from allyl halides.
Topics: Acetylcysteine; Alkenes; Allyl Compounds; Animals; Bile; Bromine; Chlorine; Chromatography, Gas; Chromatography, Paper; Cysteine; Glutathione; Iodine; Male; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Sulfoxides; Sulfur Isotopes; Yeasts | 1972 |
Metabolism of a glutathione conjugate of 2-hydroxyoestradiol-17 in the adult male rat.
Topics: Acetylcysteine; Animals; Bile; Chromatography, DEAE-Cellulose; Chromatography, Paper; Cysteine; Electrophoresis; Estradiol; Ethers; Feces; Glutathione; Injections, Intraperitoneal; Male; Protein Binding; Sulfur Isotopes; Tritium | 1972 |
Comparative mucolytic studies on dithiothreitol, N-acetyl-cysteine and L-cysteine on human respiratory mucus in vitro and their effects on the rate of flow of mucus in the exposed trachea of the rat on topical application.
Topics: Acetylcysteine; Animals; Bronchi; Cysteine; Dithiothreitol; Humans; In Vitro Techniques; Irritants; Models, Biological; Mucus; Rats; Rheology; Stimulation, Chemical; Trachea; Viscosity | 1971 |
The metabolism of thiophen in the rabbit and the rat.
Topics: Acetylcysteine; Animals; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Cysteine; Feces; Female; Mass Spectrometry; Rabbits; Rats; Spectrophotometry, Infrared; Sulfates; Sulfur Radioisotopes; Thiophenes | 1971 |
N-acetylcysteine inactivates migration inhibitory factor and delayed hypersensitivity reactions.
Topics: Acetylcysteine; Animals; Cell Migration Inhibition; Cell Movement; Culture Techniques; Cysteine; Guinea Pigs; Hypersensitivity, Delayed; Lymphocyte Activation; Macrophages; Pulmonary Alveoli; Uremia | 1971 |
Ham-positive red cells induced in vitro by N-acetylcysteine or D-penicillamine.
Topics: Acetylcholinesterase; Acetylcysteine; beta-Aminoethyl Isothiourea; Cysteine; Erythrocytes; Hemolysis; Humans; In Vitro Techniques; Penicillamine | 1968 |
N-acetylcysteine-cysteine disulfide excretion in the urine following N-acetylcysteine administration.
Topics: Acetylcysteine; Amino Acid Metabolism, Inborn Errors; Chromatography; Cysteine; Female; Humans; Infant; Infant, Newborn; Male; Mass Screening; Sulfides | 1969 |
Some observations on the source of cysteine for mercapturic acid formation.
Topics: Acetylcysteine; Animals; Cysteine; Female; Glutathione; In Vitro Techniques; Liver; Rats | 1969 |
Metabolic studies with acetylcysteine.
Topics: Acetylcysteine; Adrenal Glands; Animals; Chromatography, Paper; Cysteine; Dogs; Female; Kidney; Liver; Lung; Muscles; Rats; Spleen; Sulfates; Sulfhydryl Compounds; Sulfur Isotopes; Taurine | 1966 |
In vivo antiviral chemotherapy. II. Anti-influenza action of compounds affecting mucous secretions.
Topics: Acetylcysteine; Animals; Cysteine; Mice; Mucus; Orthomyxoviridae Infections; Parasympatholytics; Parasympathomimetics | 1966 |
[Mucolytic action "in vitro" of the methyl ester of cysteine compared with the action of N-acetyl-L-cysteine].
Topics: Acetylcysteine; Cysteine; Expectorants; Gastric Mucins; In Vitro Techniques; Sputum | 1967 |
Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds.
Topics: Acetylcysteine; Animals; Cattle; Coronary Vessels; Cysteine; Dithiothreitol; Enzyme Activation; Ferricyanides; Glutathione; Guanylate Cyclase; Kinetics; Liver; Methemoglobin; Myoglobin; Nitroso Compounds; Protein Binding; Rats; S-Nitrosoglutathione; S-Nitrosothiols; Sulfhydryl Compounds; Thioglucosides; Valine | 1980 |
Reduction of the secretory response to Escherichia coli heat-stable enterotoxin by thiol and disulfide compounds.
Topics: Acetylcysteine; Animals; Bacterial Toxins; Body Fluids; Cyclic GMP; Cystamine; Cystathionine; Cysteamine; Cysteine; Cystine; Disulfides; Enterotoxins; Enzyme Activation; Escherichia coli Proteins; Guanylate Cyclase; Intestinal Mucosa; Mice; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1983 |
Glutathione biosynthesis in the isolated perfused rat lung: utilization of extracellular glutathione.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutamates; Glutathione; In Vitro Techniques; Lung; Male; Methionine Sulfoximine; Perfusion; Rats; Rats, Inbred Strains | 1984 |
Determination of glutathione in biological material by high pressure liquid chromatography.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine; Dinitrochlorobenzene; Escherichia coli; Glutathione; Liver; Rats | 1983 |
In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens.
Topics: Acetylcysteine; Animals; Biotransformation; Carcinogens; Cysteine; Drug Interactions; Glutathione; Glutathione Disulfide; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1984 |
Mechanism of action of paracetamol protective agents in mice in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Buthionine Sulfoximine; Cysteamine; Cysteine; Glutathione; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
Nutritional improvement of soy flour.
Topics: Acetylcysteine; Animals; Body Weight; Cysteine; Dietary Proteins; Flour; Food, Formulated; Glycine max; Hot Temperature; Hydrogen-Ion Concentration; Male; Nitrogen; Nutritive Value; Rats; Sulfhydryl Compounds; Trypsin Inhibitors | 1984 |
The formation of a novel mercapturic acid during the metabolism of an N-methyl aromatic amine, 4-cyano-N,N-dimethylaniline.
Topics: Acetylcysteine; Aniline Compounds; Animals; Cysteine; Dealkylation; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344 | 1984 |
Thiols, thiol depletion, and thermosensitivity.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cricetinae; Cysteine; Glutathione; Heat-Shock Proteins; Hot Temperature; Maleates; Methionine Sulfoximine; Oxidation-Reduction; Oxygen Consumption; Protein Biosynthesis; Sulfhydryl Compounds; Time Factors | 1983 |
A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Carbocysteine; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteine; Humans; In Vitro Techniques; Kidney; Male; Mesocricetus; Microsomes, Liver; Protein Binding | 1983 |
The effect of cysteine and N-acetyl cysteine on rat liver glutathione (GSH).
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Cysteine; Glutathione; Injections, Intraperitoneal; Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1983 |
Use of local electrostatic environments of cysteines to enhance formation of a desired species in a reversible disulfide exchange reaction.
Topics: Acetylcysteine; Cysteine; Disulfides; Electrochemistry; Kinetics; Osmolar Concentration; Peptide Fragments; Structure-Activity Relationship; Sulfhydryl Reagents; Trypsin Inhibitor, Kunitz Soybean; Trypsin Inhibitors | 1983 |
Hepato-renal cooperation in biotransformation, membrane transport, and elimination of cysteine S-conjugates of xenobiotics.
Topics: Acetylation; Acetylcysteine; Animals; Biological Transport; Biotransformation; Cell Membrane; Cysteine; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Liver; Male; Pharmaceutical Preparations; Rats; Rats, Inbred Strains | 1984 |
[Adsorption of antidotes by carbon hemosorbents].
Topics: Acetylcysteine; Aconitine; Adsorption; Antidotes; Charcoal; Cysteine; Hemoperfusion; In Vitro Techniques; Kinetics; Lidocaine | 1984 |
Kinetic mechanism and specificity of bovine milk sulphydryl oxidase.
Topics: Acetylcysteine; Animals; Cattle; Cystamine; Cysteine; Female; Kinetics; Milk; Oxidoreductases; Substrate Specificity | 1984 |
Topological aspects of microsomal N-acetyltransferase, an enzyme responsible for the acetylation of cysteine S-conjugates of xenobiotics.
Topics: Acetylation; Acetylcysteine; Acetyltransferases; Animals; Anions; Cysteine; Cytoplasm; Inactivation, Metabolic; Kidney; Microsomes; Microsomes, Liver; Rats; Sulfobromophthalein | 1984 |
The formation of arylating and alkylating metabolites of phenacetin in hamsters and hamster liver microsomes.
Topics: Acetylcysteine; Alkylation; Animals; Ascorbic Acid; Biotransformation; Carbon Dioxide; Cricetinae; Cysteine; Glutathione; In Vitro Techniques; Microsomes, Liver; Phenacetin; Protein Binding | 1981 |
Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis.
Topics: Acetylcysteine; Animals; Antioxidants; Benzoates; Benzoic Acid; Catalase; Cattle; Cysteine; Free Radicals; Humans; Mannitol; Mutagenicity Tests; Oxygen; Phagocytes; Salmonella; Superoxide Dismutase | 1982 |
Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats.
Topics: Acetylcysteine; Animals; Brain; Cysteine; Dose-Response Relationship, Drug; Glutathione; Rats; Rats, Inbred Strains | 1983 |
Acetylcysteine and its derivatives: functional and morphological effects on tracheal mucosa in vitro.
Topics: Acetylcysteine; Cysteine; Cystine; Glutathione; Humans; Mucous Membrane; Trachea | 1983 |
Biological properties of acetylcysteine: assay development and pharmacokinetic studies.
Topics: Acetylcysteine; Adult; Blood Proteins; Cysteine; Disulfides; Humans; Kinetics; Male; Sulfhydryl Compounds | 1980 |
The effect of mucolytic agents on the rheologic and transport properties of canine tracheal mucus.
Topics: Acetylcysteine; Animals; Carbocysteine; Cysteine; Dithiothreitol; Dogs; Elasticity; Expectorants; In Vitro Techniques; Mucus; Potassium Iodide; Rana catesbeiana; Rheology; Trachea; Urea; Viscosity | 1980 |
Cooxidation of benzidine by horseradish peroxidase and subsequent formation of possible thioether conjugates of benzidine.
Topics: Acetylcysteine; Benzidines; Chemical Phenomena; Chemistry; Cysteine; Glutathione; Horseradish Peroxidase; Hydrogen Peroxide; Hydrogen-Ion Concentration; Oxidation-Reduction; Peroxidases; Sulfides | 1982 |
Fast atom bombardment mass spectra of mercapturic acid-pathway metabolites of propachlor (2-chloro-N-isopropylacetanilide).
Topics: Acetanilides; Acetylcysteine; Cysteine; Glutathione; Mass Spectrometry; Molecular Weight | 1982 |
[The use of cysteine and acetylcysteine collyria in chemical burns of the cornea. Experimental studies].
Topics: Acetylcysteine; Acid Phosphatase; Animals; Burns, Chemical; Corneal Injuries; Cysteine; Eye Burns; Gels; L-Lactate Dehydrogenase; Ophthalmic Solutions; Rabbits | 1982 |
New findings on acrylonitrile metabolism.
Topics: Acetylcysteine; Acrylonitrile; Administration, Oral; Animals; Chromatography, Gel; Chromatography, Paper; Cysteine; Injections, Intraperitoneal; Injections, Intravenous; Nitriles; Rabbits; Rats | 1980 |
Chemical debridement of burns: mercaptans.
Topics: Acetylcysteine; Animals; Bromelains; Burns; Cysteine; Debridement; Drug Evaluation, Preclinical; Humans; Male; Mercaptoethanol; Penicillamine; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Swine | 1981 |
Effects of microsomal enzyme induction on paracetamol metabolism in man.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Anticonvulsants; Antipyrine; Cysteine; Enzyme Induction; Female; Half-Life; Humans; Liver; Male; Microsomes, Liver; Middle Aged | 1981 |
[Preparation of eye drops with zinc sulphate and adrenaline (author's transl)].
Topics: Acetylcysteine; Chemistry, Pharmaceutical; Cysteine; Drug Compounding; Drug Stability; Epinephrine; Ophthalmic Solutions; Sulfates; Sulfites; Time Factors; Zinc; Zinc Sulfate | 1981 |
Effects of expectorants on the canine tracheal ciliated cells.
Topics: Acetylcholine; Acetylcysteine; Animals; Bromhexine; Cilia; Cysteine; Dogs; Expectorants; In Vitro Techniques; Male; Mucus; Potassium; Trachea | 1981 |
[A sensitive fluorometric determination of N-acetyl-L-cysteine in biological fluids by high performance liquid chromatography (author's transl)].
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine; Kidney; Liver; Rats | 1981 |
Renal metabolism of paracetamol: studies in the isolated perfused rat kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Kidney Tubules; Rats; Time Factors | 1980 |
Identification of the major urinary metabolites of acrylonitrile in the rat.
Topics: Acetylcysteine; Acrylonitrile; Animals; Biotransformation; Cysteine; Male; Nitriles; Rats; Thiazines; Thiocyanates | 1980 |
Promotion of cyst(e)ine uptake.
Topics: Acetylcysteine; Animals; Biological Transport; Cell Adhesion; CHO Cells; Cricetinae; Cysteamine; Cysteine; Cystine; Glutathione; Sulfhydryl Compounds | 1995 |
Tolerance to nitroglycerin in vascular smooth muscle cells is not affected by the level of intracellular glutathione or L-cysteine.
Topics: Acetylcysteine; Animals; Cyclic GMP; Cysteine; Cytoplasm; Drug Tolerance; Free Radical Scavengers; Glutathione; Muscle, Smooth, Vascular; Nitroglycerin; Sulfhydryl Reagents; Swine; Vasodilator Agents | 1995 |
Stabilities of the fluorescent SH-reagent eosin-5-maleimide and its adducts with sulfhydryl compounds.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine; Drug Stability; Eosine Yellowish-(YS); Ethylmaleimide; Glutathione; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Spectrometry, Fluorescence; Spectrometry, Mass, Fast Atom Bombardment; Succinimides; Sulfhydryl Compounds | 1995 |
Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide.
Topics: Acetylcysteine; Amino Acid Sequence; Cell Line; Cysteine; Diterpenes; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Molecular Sequence Data; Peptides; Protein Methyltransferases; S-Adenosylhomocysteine | 1995 |
Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver.
Topics: Acetylcysteine; Acid Phosphatase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Cold Temperature; Cysteine; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Oxidation-Reduction; Rats; Rats, Wistar; Reperfusion Injury | 1995 |
Thiols and the immune system: effect of N-acetylcysteine on T cell system in human subjects.
Topics: Acetylcysteine; Animals; Cell Line; Cells, Cultured; Culture Techniques; Cysteine; Cytotoxicity, Immunologic; Gene Expression; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Hydrocortisone; Immunotherapy; Leukemia L5178; Lymphocyte Activation; Mercaptoethanol; Mice; Mice, Inbred C3H; Mice, Inbred DBA; NF-kappa B; Receptors, Interleukin-2; Spleen; Sulfhydryl Compounds; T-Lymphocytes; T-Lymphocytes, Cytotoxic | 1995 |
Positive inotropic effect of acetylcysteine in cardiomyopathic Syrian hamsters.
Topics: Acetylcysteine; Analysis of Variance; Animals; Cardiomyopathies; Cricetinae; Cysteine; Cystine; Male; Mesocricetus; Myocardial Contraction; Papillary Muscles; Ryanodine; Stimulation, Chemical; Verapamil | 1993 |
S-prenylated cysteine analogues inhibit receptor-mediated G protein activation in native human granulocyte and reconstituted bovine retinal rod outer segment membranes.
Topics: Acetylcysteine; Animals; Cattle; Cell Line; Cell Membrane; Cysteine; Granulocytes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Rod Cell Outer Segment; Structure-Activity Relationship | 1995 |
Rapid tolerance to formation of authentic NO from nitroglycerin in vivo.
Topics: Acetylcysteine; Animals; Arginine; Cysteine; Drug Tolerance; Glutathione; Hemodynamics; Infusions, Intravenous; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pulmonary Circulation; Rabbits | 1995 |
Supplementation of N-acetylcysteine fails to increase glutathione in lymphocytes and plasma of patients with AIDS.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Adult; Cysteine; Female; Glutathione; Humans; Lymphocytes; Male; Middle Aged | 1995 |
Modulation of transcription factor NF kappa B activity by intracellular glutathione levels and by variations of the extracellular cysteine supply.
Topics: Acetylcysteine; Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Glutathione; Glutathione Disulfide; HIV; HIV Infections; Humans; Kinetics; Macaca mulatta; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Sulfhydryl Compounds; T-Lymphocytes; Transcriptional Activation | 1995 |
The reactivity of thiol compounds with different redox states of leghaemoglobin: evidence for competing reduction and addition pathways.
Topics: 3-Mercaptopropionic Acid; Acetylcysteine; Cysteamine; Cysteine; Disulfides; Electron Spin Resonance Spectroscopy; Ferric Compounds; Glycine max; Hydrogen Peroxide; Leghemoglobin; Mercaptoethanol; Oxidation-Reduction; Sulfhydryl Compounds; Sulfides; Thioctic Acid | 1995 |
Effects of N-acetylcysteine stereoisomers on oxygen-induced lung injury in rats.
Topics: Acetylcysteine; Administration, Oral; Animals; Cysteine; Disease Models, Animal; Glutathione; Hyperemia; Infusion Pumps, Implantable; Infusions, Intravenous; Lung; Male; Osmosis; Oxygen; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1995 |
Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.
Topics: Acetylcysteine; Animals; Anion Transport Proteins; Carrier Proteins; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Mercuric Chloride; p-Aminohippuric Acid; Probenecid; Rabbits | 1995 |
In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols.
Topics: Acetylcysteine; Animals; Biological Transport; Blood Pressure; Chromatography, High Pressure Liquid; Cysteine; Mercaptoethanol; Nitric Oxide; Nitrosation; Nitroso Compounds; Protein Binding; Rabbits; S-Nitrosothiols; Serum Albumin, Bovine; Sulfhydryl Compounds; Vascular Resistance | 1994 |
ATP-sensitive K+ channels of skeletal muscle fibers from young adult and aged rats: possible involvement of thiol-dependent redox mechanisms in the age-related modifications of their biophysical and pharmacological properties.
Topics: Acetylcysteine; Adenosine Triphosphate; Aging; Animals; Cysteine; Glyburide; In Vitro Techniques; Male; Muscle, Skeletal; Oxidation-Reduction; Potassium Channels; Rats; Rats, Inbred WKY; Thimerosal | 1994 |
Identification and quantification of the N-acetylcysteine conjugate of allyl isothiocyanate in human urine after ingestion of mustard.
Topics: Acetylcysteine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Diet; Dose-Response Relationship, Drug; Female; Food Preservatives; Humans; Isothiocyanates; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mustard Plant; Plants, Medicinal; Spectrophotometry, Ultraviolet; Thiocarbamates; Time Factors | 1994 |
Detection of nitric oxide in exhaled air during administration of nitroglycerin in vivo.
Topics: Acetylcysteine; Adenosine; Animals; Arginine; Blood Pressure; Cysteine; Glutathione; Heart Rate; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pulmonary Artery; Pulmonary Veins; Rabbits; Vascular Resistance | 1994 |
Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cells, Cultured; Cerebral Cortex; Cycloheximide; Cysteine; Glutamates; Glutathione; Homocysteine; Macromolecular Substances; Methionine Sulfoximine; Neurons; Oxidants; Protein Biosynthesis; Proteins; Rats | 1994 |
The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine.
Topics: Acetylcysteine; Animals; Cells, Cultured; Culture Media; Cysteine; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Selenium Radioisotopes; Thiazoles; Thiazolidines | 1994 |
Attenuation of acetaminophen hepatotoxicity in mice as evidence for the bioavailability of the cysteine in D-glucose-L-cysteine in vivo.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Biological Availability; Cysteine; Drug Interactions; Glucose; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred ICR | 1994 |
Generation of free radicals in reactions of Ni(II)-thiol complexes with molecular oxygen and model lipid hydroperoxides.
Topics: Acetylcysteine; Benzene Derivatives; Cysteine; Electron Spin Resonance Spectroscopy; Free Radicals; Histidine; Lipid Peroxides; Nickel; Oxygen; Penicillamine; Peroxides; Sulfhydryl Compounds; tert-Butylhydroperoxide | 1993 |
Determination of thiol-containing drugs by chemiluminescence-flow injection analysis.
Topics: Acetylcysteine; Catalysis; Copper; Cysteine; Flow Injection Analysis; Hydrogen Peroxide; Hydrogen-Ion Concentration; Luminescent Measurements; Luminol; Penicillamine; Sulfhydryl Compounds; Tiopronin | 1993 |
Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices.
Topics: Acetylcysteine; Alkenes; Animals; Cysteine; Dose-Response Relationship, Drug; Hydrocarbons, Halogenated; In Vitro Techniques; Kidney; Male; Rats; Rats, Wistar; Structure-Activity Relationship | 1993 |
Liver damage and plasma concentrations of paracetamol and its metabolites after paracetamol overdosage in mice.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Cysteine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Liver; Male; Mice | 1993 |
Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors.
Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Lung; Male; Maleates; Rats; Rats, Wistar | 1993 |
Piggy-back race.
Topics: Acetylcysteine; Animals; Binding, Competitive; Brain; Capillaries; Cells, Cultured; Cysteine; Endothelium, Vascular; Glutathione; Homocysteine; Leucine; Methylmercury Compounds; Penicillamine; Stereoisomerism; Sulfhydryl Compounds | 1995 |
Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Culture Media, Conditioned; Cycloheximide; Cysteine; Cytotoxicity, Immunologic; fas Receptor; Glutathione; Humans; Immunity, Innate; Intracellular Fluid; Killer Cells, Lymphokine-Activated; Leukemia, T-Cell; Lymphocyte Activation; Methionine Sulfoximine; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Inhibitors of farnesyl and geranylgeranyl methyltransferases prevent beta 2 integrin-induced actin polymerization without affecting beta 2 integrin-induced Ca2+ signaling in neutrophils.
Topics: Acetylcysteine; Actins; Antibodies, Monoclonal; Calcium; CD18 Antigens; Cysteine; Cytosol; Diterpenes; Enzyme Inhibitors; Humans; Integrins; Neutrophils; Protein Methyltransferases; Signal Transduction | 1996 |
Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes.
Topics: Acetylcysteine; Animals; Biotransformation; Cell Membrane; Cysteine; Cystine; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytoskeleton; Dexamethasone; Diterpenes; Diterpenes, Clerodane; Female; Glutathione; Liver; Male; Mixed Function Oxygenases; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Spiro Compounds; Troleandomycin | 1996 |
N-acetylcysteine inhibits germination of conidia and growth of Aspergillus spp. and Fusarium spp.
Topics: Acetylcysteine; Antifungal Agents; Aspergillus; Cysteine; Dose-Response Relationship, Drug; Fusarium; Microbial Sensitivity Tests; Spores, Fungal | 1996 |
Biotransformation of allyl chloride in the rat. Influence of inducers on the urinary metabolic profile.
Topics: Acetylcysteine; Allyl Compounds; alpha-Chlorohydrin; Animals; beta-Naphthoflavone; Biomarkers; Biotransformation; Cysteine; Enzyme Induction; Male; Rats; Rats, Wistar | 1996 |
In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine.
Topics: Acetylcysteine; Animals; Brain; Cysteine; Glutathione; Lead; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxidative Stress; Succimer | 1996 |
Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection.
Topics: Acetylcysteine; Animals; Antioxidants; Brain Chemistry; Cysteine; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Glutathione; Male; Metallothionein; Mice; Mice, Inbred C57BL; Nervous System Diseases; Nitrites; Superoxides | 1996 |
Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates.
Topics: Acetylcysteine; Animals; Cysteine; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Glutathione; Humans; In Vitro Techniques; Isothiocyanates; Kinetics; Male; Microsomes, Liver; Rats; Rats, Inbred F344 | 1996 |
Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives.
Topics: Acetylcysteine; Aging; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Cystine; Female; Glutathione; Glutathione Disulfide; Liver; Male; Maleates; Mice; Rats; Rats, Inbred F344; Species Specificity | 1996 |
Isolation and characterization of N-acetyl-S-[2-carboxy-1-(1 H-imidazol-4-yl) ethyl]-L-cysteine, a new metabolite of histidine, from normal human urine and its formation from S-[2-carboxy-1-(1 H-imidazol-4-yl) ethyl]-L-cysteine.
Topics: Acetylation; Acetylcysteine; Acetyltransferases; Amino Acids; Animals; Chromatography, Ion Exchange; Cysteine; Histidine; Humans; Imidazoles; Kidney; Liver; Male; Models, Chemical; Organ Specificity; Rats; Rats, Wistar; Stereoisomerism; Urocanic Acid | 1996 |
Metal-catalyzed inactivation of bovine glucose-6-phosphate dehydrogenase--role of thiols.
Topics: Acetylcysteine; Adenosine Diphosphate; Animals; Cattle; Cysteine; Dipeptides; Edetic Acid; Enzyme Activation; Glucosephosphate Dehydrogenase; Glutathione; Hydrogen Peroxide; Hypoxanthine; Iron; Metals; Oxidation-Reduction; Sulfhydryl Compounds; Xanthine Oxidase | 1996 |
Intracellular glutathione as a possible direct blocker of HIV type 1 reverse transcription.
Topics: Acetylcysteine; Aspartic Acid; Cysteine; Dithiothreitol; DNA, Viral; Glutathione; HIV Reverse Transcriptase; HIV-1; Humans; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.
Topics: Acetylcysteine; Administration, Inhalation; Adult; Aged; Animals; Biotransformation; Cysteine; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Male; Middle Aged; Rats; Trichloroethylene | 1996 |
Defective antigen processing correlates with a low level of intracellular glutathione.
Topics: Acetylcysteine; Animals; Antigen Presentation; Biological Transport; CHO Cells; Cricetinae; Cysteine; Cytochrome c Group; Glutathione; Hybrid Cells; Intracellular Fluid; L Cells; Methionine Sulfoximine; Mice; Muramidase | 1996 |
On the mechanism of the inhibition of transducin function by farnesylcysteine analogs.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Cattle; Cysteine; GTP-Binding Proteins; Molecular Sequence Data; Rod Cell Outer Segment; Structure-Activity Relationship; Transducin | 1997 |
Improved method for the recovery of Ascarus suum larvae from pig intestinal mucosa.
Topics: Acetylcysteine; Animals; Ascariasis; Ascaris suum; Cecum; Colon; Cysteine; Female; Free Radical Scavengers; Intestinal Diseases, Parasitic; Intestinal Mucosa; Larva; Oxidation-Reduction; Pepsin A; Solubility; Swine; Swine Diseases | 1997 |
The effect of L-cysteine and N-acetylcysteine on porphyrin/heme biosynthetic pathway in cells treated with 5-aminolevulinic acid and exposed to radiation.
Topics: Acetylcysteine; Aminolevulinic Acid; Cells, Cultured; Cysteine; Endothelium, Vascular; Ferrochelatase; Heme; Humans; Porphyrins; Ultraviolet Rays | 1996 |
Oral N-acetylcysteine protects against perfluoroisobutene toxicity in rats.
Topics: Acetylcysteine; Administration, Oral; Animals; Bronchoalveolar Lavage Fluid; Cysteine; Female; Fluorocarbons; Glutathione; Lung; Pulmonary Edema; Rats; Rats, Wistar | 1997 |
Aromatase inactivation by a suicide substrate, androst-5-ene-4,7,17-trione: the 5beta,6beta-epoxy-19-oxo derivative, as a possible reactive electrophile irreversibly binding to the active site.
Topics: Acetylcysteine; Androstanes; Androstenedione; Androstenes; Aromatase Inhibitors; Binding Sites; Binding, Competitive; Cysteine; Female; Humans; In Vitro Techniques; Kinetics; Microsomes; NADP; Placenta; Pregnancy | 1997 |
Excretion of N-acetyl-S-(1-phenyl-2-hydroxyethyl)-cysteine and N-acetyl-S-(2-phenyl-2-hydroxyethyl)-cysteine in workers exposed to styrene.
Topics: Acetylcysteine; Animals; Binding Sites; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cysteine; Environmental Monitoring; Epoxy Compounds; Glutathione; Glyoxylates; Humans; Male; Mandelic Acids; Mercaptoethanol; o-Phthalaldehyde; Occupational Exposure; Rats; Reference Standards; Spectrometry, Fluorescence; Stereoisomerism; Styrene; Styrenes; Ultrafiltration | 1997 |
Protein prenylation is required for aldosterone-stimulated Na+ transport.
Topics: Acetylcysteine; Aldosterone; Animals; Biological Transport; Cell Line; Cysteine; Dimethylallyltranstransferase; Diterpenes; Enzyme Inhibitors; Epithelium; Farnesol; Insulin; Kidney; Kinetics; Lovastatin; Organophosphonates; Protein Prenylation; Sodium | 1997 |
Cysteine S-conjugates activate transcription factor NF-kappa B in cultured renal epithelial cells.
Topics: Acetylcysteine; Aminooxyacetic Acid; Animals; Antioxidants; Base Sequence; Cell Line; Cell Nucleus; Consensus Sequence; Cysteine; Cytosol; Epithelium; Genes, Reporter; Kidney; Luciferases; Macromolecular Substances; NF-kappa B; Oligodeoxyribonucleotides; Recombinant Fusion Proteins; Swine; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha | 1997 |
Glutathione and N-acetylcysteine reduce gastric mucosal blood flow in rats.
Topics: Acetylcysteine; Animals; Blood Flow Velocity; Cardiac Output; Cysteine; Gastric Mucosa; Glutathione; Male; Microspheres; Rats | 1997 |
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microdialysis; Neoplasm Transplantation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Determination of glutathione, cysteine and N-acetylcysteine in rabbit eye tissues using high-performance liquid chromatography and post-column derivatization with 5,5'-dithiobis(2-nitrobenzoic acid).
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine; Dithionitrobenzoic Acid; Eye; Glutathione; Hydrogen-Ion Concentration; Lens, Crystalline; Rabbits; Reference Values; Retina; Spectrophotometry, Ultraviolet; Sulfhydryl Reagents; Vitrectomy; Vitreous Body | 1997 |
Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cysteine; Dose-Response Relationship, Radiation; Female; Fibroblasts; Glutathione; Humans; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Skin; Sodium Selenite; Surgery, Plastic; Thiazoles; Thiazolidines; Thiophenes; Ultraviolet Rays | 1997 |
Liver intracellular L-cysteine concentration is maintained after inhibition of the trans-sulfuration pathway by propargylglycine in rats.
Topics: Acetylcysteine; Alkynes; Animals; Cystathionine; Cystathionine gamma-Lyase; Cysteine; Depression, Chemical; Glutathione; Glycine; Liver; Male; Methionine; Rats; Rats, Wistar; Urea | 1997 |
Glutathione synthesis during in vitro maturation of bovine oocytes: role of cumulus cells.
Topics: Acetylcysteine; Animals; Cattle; Cells, Cultured; Coculture Techniques; Cysteamine; Cysteine; Cystine; Female; Glutathione; Oocytes; Ovarian Follicle | 1997 |
Biotransformation, excretion and nephrotoxicity of haloalkene-derived cysteine S-conjugates.
Topics: Acetylation; Acetylcysteine; Animals; Biotransformation; Butadienes; Cysteine; Female; gamma-Glutamyltransferase; Kidney; Liver; Male; Necrosis; Rats; Rats, Wistar; Sex Factors | 1997 |
Role of glutathione in nitric oxide-dependent regulation of energy metabolism in rat hepatoma cells.
Topics: Acetylcysteine; Adenosine Diphosphate; Animals; Cysteine; Digitonin; Dose-Response Relationship, Drug; Energy Metabolism; Glutathione; Liver Neoplasms, Experimental; Male; Mercaptoethanol; Metallothionein; Mitochondria; Nitric Oxide; Nitroso Compounds; Rats; Rats, Inbred Strains; S-Nitrosoglutathione; S-Nitrosothiols; Time Factors | 1998 |
N-acetylcysteine causes a transient stimulation of neutrophil migration.
Topics: Acetylcysteine; Animals; Calcium; Cell Movement; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Cysteine; Free Radical Scavengers; Guanylate Cyclase; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Rabbits | 1998 |
Diverse relaxation responses of canine large and small conductive coronary arteries to glyceryl trinitrate and nitric oxide on the one hand and to 8-bromoguanosine 3':5' cyclic monophosphate on the other.
Topics: Acetylcysteine; Animals; Biotransformation; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cysteine; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Female; Free Radical Scavengers; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Vasodilation; Vasodilator Agents | 1998 |
Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury.
Topics: Acetylcysteine; Analysis of Variance; Animals; Biological Transport; Cysteine; Disease Models, Animal; Drug Interactions; Feces; Homocysteine; Kidney; Kidney Tubules, Proximal; Ligation; Liver; Male; Mercury; Normal Distribution; Rats; Rats, Sprague-Dawley; Reference Values; Ureter; Urine | 1998 |
Glutathione S-conjugate formation and metabolism in HepG2 cells: a cell model of mercapturic acid biosynthesis.
Topics: Acetylcysteine; Biological Transport; Carcinoma, Hepatocellular; Cysteine; Dinitrochlorobenzene; Glutathione; Humans; Inactivation, Metabolic; Liver Neoplasms; Models, Biological; Tumor Cells, Cultured | 1998 |
Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition.
Topics: Acetylcysteine; Animals; CHO Cells; Cricetinae; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylphosphatidylinositols; Human Growth Hormone; Humans; Leupeptins; Multienzyme Complexes; Mutation; Peptides; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Sulfhydryl Compounds; Ubiquitins | 1998 |
Analogs of farnesylcysteine induce apoptosis in HL-60 cells.
Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cysteine; DNA Methylation; Farnesol; Growth Inhibitors; HL-60 Cells; Humans; Proteins; ras Proteins; Subcellular Fractions | 1998 |
Involvement of tyrosine phosphorylation in inhibition of fMLP-induced PLD activation by N-acetyl-L-cysteine in differentiated HL60 cells.
Topics: Acetylcysteine; Androstadienes; Cell Differentiation; Chelating Agents; Cysteine; Dithiothreitol; Enzyme Activation; Free Radical Scavengers; HL-60 Cells; Humans; Inositol Phosphates; N-Formylmethionine Leucyl-Phenylalanine; Oxidants; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorylation; Sulfhydryl Reagents; Tyrosine; Unithiol; Wortmannin | 1998 |
Chromatographic separation of fluorescent thiol adducts of 4-chloro-7-sulphobenzofurazan. Use as substrates for enzymes of the mercapturic acid xenobiotic pathway.
Topics: Acetylcysteine; Animals; Benzoxazoles; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Enzymes; Fluorescence; Glutathione; Rats; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Xenobiotics | 1998 |
Analysis of cysteine and N-acetylcysteine in human plasma by high-performance liquid chromatography at the basal state and after oral administration of N-acetylcysteine.
Topics: Acetylcysteine; Adult; Catalysis; Chromatography, High Pressure Liquid; Cysteine; Evaluation Studies as Topic; Female; Humans; Male; Nitrous Acid | 1998 |
The nephrotoxicity and hepatotoxicity of 1,1,2,2-tetrafluoroethyl-L-cysteine in the rat.
Topics: Acetylcysteine; Aminooxyacetic Acid; Animals; Butadienes; Cysteine; Dose-Response Relationship, Drug; Female; Hydrocarbons, Fluorinated; Ion Transport; Kidney Diseases; Male; Probenecid; Rats; Renal Agents | 1998 |
[The inhibitory effect and the mechanism of ethanol absorption by zinc complex in mouse gastrointestinal tract].
Topics: Acetates; Acetylcysteine; Animals; Cysteine; Ethanol; Intestinal Absorption; Male; Mice; Zinc | 1998 |
A simple colorimetric method for the simultaneous determination of N-acetylcysteine and cysteine.
Topics: Acetylcysteine; Amidohydrolases; Animals; Antioxidants; Colorimetry; Cysteine; Swine | 1998 |
Synthesis and structure elucidation of estrogen quinones conjugated with cysteine, N-acetylcysteine, and glutathione.
Topics: Acetylcysteine; Cysteine; Estrogens, Catechol; Glutathione; Magnetic Resonance Spectroscopy; Mass Spectrometry; Quinones | 1998 |
Basolateral uptake of mercuric conjugates of N-acetylcysteine and cysteine in the kidney involves the organic anion transport system.
Topics: Acetylcysteine; Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Cysteine; Drug Combinations; Injections, Intravenous; Kidney; Ligation; Liver; Male; Mercuric Chloride; p-Aminohippuric Acid; Rats; Rats, Sprague-Dawley; Tissue Distribution; Ureter | 1998 |
Free radicals as potential mediators of metal-allergy: Ni2+- and Co2+-mediated free radical generation.
Topics: Acetylcysteine; Adult; Ascorbic Acid; Carnosine; Cells, Cultured; Cobalt; Cysteine; Dermatitis, Allergic Contact; Electron Spin Resonance Spectroscopy; Female; Free Radical Scavengers; Free Radicals; Glutathione; Histidine; Humans; Hydrogen Peroxide; Middle Aged; Monocytes; Nickel | 1998 |
Reducing compounds initiate the TRP2-catalyzed conversion of L-dopachrome to DHICA.
Topics: Acetylcysteine; Animals; Cysteine; Indolequinones; Indoles; Intramolecular Oxidoreductases; Melanoma, Experimental; Mice; Oxidation-Reduction; Quinones; Rabbits; Reducing Agents | 1998 |
Radiation-sensitive tyrosine phosphorylation of cellular proteins: sensitive to changes in GSH content induced by pretreatment with N-acetyl-L-cysteine or L-buthionine-S,R-sulfoximine.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; CHO Cells; Cricetinae; Cysteine; Free Radical Scavengers; Glutathione; Hydrogen Peroxide; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Reactive Oxygen Species; Signal Transduction | 1998 |
Effects of N-acetylcysteine and 2,3-dimercaptosuccinic acid on lead induced oxidative stress in rat lenses.
Topics: Acetylcysteine; Animals; Chelating Agents; Chromatography, High Pressure Liquid; Cysteine; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Lens, Crystalline; Male; Malondialdehyde; Organometallic Compounds; Oxidative Stress; Rats; Rats, Inbred F344; Succimer | 1998 |
Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants.
Topics: Acetylcysteine; Alanine Transaminase; Amitrole; Animals; Anti-Inflammatory Agents; Antioxidants; Buthionine Sulfoximine; Cadmium; Cysteine; Drug Combinations; Enzyme Inhibitors; Female; Glutathione; Glycine; Glycyrrhetinic Acid; Kidney; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Malondialdehyde; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Steroids; Time Factors; Vitamin E | 1999 |
Effects of bucillamine and N-acetyl-L-cysteine on cytokine production and collagen-induced arthritis (CIA).
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Arthritis, Experimental; Cholesterol; Collagen; Cysteine; Humans; Male; Mice; Mice, Inbred DBA; NF-kappa B; Phospholipids; Rats; Rats, Wistar; Triglycerides; Tumor Cells, Cultured | 1999 |
Postcolumn reaction detection with dual-electrode capillary electrophoresis-electrochemistry and electrogenerated bromine.
Topics: Acetylcysteine; Bromine; Cysteine; Electrochemistry; Electrodes; Electrophoresis, Capillary; Glutathione; Sulfhydryl Compounds | 1999 |
N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain.
Topics: Acetylcysteine; Animals; Brain; Cells, Cultured; Cysteine; Female; Glutathione; Methionine; Neurons; Pregnancy; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1999 |
Fates and vascular action of S-nitrosoglutathione and related compounds in the circulation.
Topics: Acetylcysteine; Animals; Blood Pressure; Cysteine; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Nitric Oxide; Nitroso Compounds; Rats; Rats, Wistar; S-Nitrosoglutathione; S-Nitrosothiols | 1999 |
Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats.
Topics: Acetylcysteine; Alkynes; Amino Acids; Animals; Cystathionine gamma-Lyase; Cysteine; Cystine; Dietary Proteins; Enzyme Inhibitors; Female; Glutathione; Glycine; Lactation; Liver; Mammary Glands, Animal; Milk; Oxidation-Reduction; Rats; Rats, Wistar | 1999 |
Investigations of S-transnitrosylation reactions between low- and high-molecular-weight S-nitroso compounds and their thiols by high-performance liquid chromatography and gas chromatography-mass spectrometry.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine; Erythrocytes; Gas Chromatography-Mass Spectrometry; Glutathione; Homocysteine; Humans; Hydroxylamine; In Vitro Techniques; Kinetics; Molecular Weight; Nitric Oxide; Nitroso Compounds; Penicillamine; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Sulfhydryl Compounds | 1999 |
The role of N-acetylcysteine in protecting synovial fluid biomolecules against radiolytically-mediated oxidative damage: a high field proton NMR study.
Topics: Acetylcysteine; Arthritis, Rheumatoid; Cysteine; Free Radicals; Gamma Rays; Humans; Knee Joint; Magnetic Resonance Spectroscopy; Oxidative Stress; Protons; Sulfhydryl Compounds; Synovial Fluid | 1999 |
Reduction of endothelial cell related TGFbeta activity by thiols.
Topics: Acetylcysteine; Animals; Cattle; Cells, Cultured; Culture Media, Conditioned; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Oxidation-Reduction; Pulmonary Artery; Sulfhydryl Compounds; Swine; Transforming Growth Factor beta | 1999 |
N-acetylcysteine blocks apoptosis induced by N-alpha-tosyl-L-phenylalanine chloromethyl ketone in transformed T-cells.
Topics: Acetylcysteine; Animals; Annexin A5; Apoptosis; Cell Division; Cell Line, Transformed; Cysteine; DNA-Binding Proteins; Flow Cytometry; Free Radical Scavengers; Humans; I-kappa B Proteins; Jurkat Cells; NF-kappa B; Phosphorylation; Serine Proteinase Inhibitors; Theileria parva; Theileriasis; Tosylphenylalanyl Chloromethyl Ketone; Transcriptional Activation | 1999 |
Differential reconstitution of mitochondrial respiratory chain activity and plasma redox state by cysteine and ornithine in a model of cancer cachexia.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Biomarkers; Blood Glucose; Cachexia; Cysteine; Cystine; Electron Transport; Energy Metabolism; Fibrosarcoma; Free Radical Scavengers; Glutathione; Glycolysis; Insulin Resistance; Mice; Mice, Inbred C57BL; Mitochondria; Models, Biological; Muscle, Skeletal; Ornithine; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Plasma; Receptor, Insulin; Serum Albumin; Spermine; Sulfhydryl Compounds | 1999 |
Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide.
Topics: Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cysteamine; Cysteine; Dithiothreitol; Glutathione; Hydrogen Peroxide; Oxygen Consumption; Penicillamine; Reactive Oxygen Species; Sulfhydryl Compounds; Superoxides; Xanthine Oxidase | 1999 |
N -Acetyl-cysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Cysteine; Female; Free Radical Scavengers; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged | 1999 |
Effects of L-cysteine and N-acetyl-L-cysteine on 4-hydroxy-2, 5-dimethyl-3(2H)-furanone (furaneol), 5-(hydroxymethyl)furfural, and 5-methylfurfural formation and browning in buffer solutions containing either rhamnose or glucose and arginine.
Topics: Acetylcysteine; Arginine; Buffers; Citrus; Cysteine; Food Additives; Food Preservation; Furaldehyde; Furans; Glucose; Humans; Maillard Reaction; Rhamnose | 1999 |
Sulfur-containing amino acids decrease cisplatin cytotoxicity and uptake in renal tubule epithelial cell lines.
Topics: Acetylcysteine; Amino Acids; Animals; Antineoplastic Agents; Cisplatin; Cysteine; Homocysteine; Humans; Kidney Tubules; Methionine; Mice; Tumor Cells, Cultured | 2000 |
Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Isolation and identification of metabolites of porfiromycin formed in the presence of a rat liver preparation.
Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; Biotransformation; Chromatography, High Pressure Liquid; Cysteine; Liver; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Porfiromycin; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 2000 |
Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Cysteine; Female; Free Radical Scavengers; Glutathione; Hydrogen Peroxide; Neurons; Oxidation-Reduction; Oxidopamine; Oxygen Consumption; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics | 2000 |
The slime loosener strikes again!
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Cysteine; HIV-1; Humans; Viral Load | 2000 |
Modulation of Rho and cytoskeletal protein attachment to membranes by a prenylcysteine analog.
Topics: Acetylcysteine; Actins; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; cdc42 GTP-Binding Protein; Cell Membrane; Cysteine; Cytoskeletal Proteins; Diterpenes; Enzyme Inhibitors; Kidney Cortex; Kinetics; Male; Microvilli; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein | 2000 |
Effects of sulfhydryl compounds on interleukin-1-induced vascular endothelial growth factor production in human synovial stromal cells.
Topics: Acetylcysteine; Cells, Cultured; Cysteine; Endothelial Growth Factors; Humans; Interleukin-1; Lymphokines; Penicillamine; Stromal Cells; Sulfhydryl Compounds; Synovial Membrane; Tiopronin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Effect of oral and intravenous S,N-diacetylcysteine monoethyl ester on circulating and hepatic sulfhydryls in the Rat.
Topics: Acetylcysteine; Administration, Oral; Animals; Cysteine; Glutathione; Injections, Intravenous; Liver; Male; Prodrugs; Rats; Rats, Sprague-Dawley | 2000 |
Thiol antioxidant, N-acetylcysteine, activates extracellular signal-regulated kinase signaling pathway in articular chondrocytes.
Topics: Acetylcysteine; Animals; Antioxidants; Blotting, Western; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Cysteine; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Free Radical Scavengers; Glutathione; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Pyrrolidines; Reactive Oxygen Species; Sulfhydryl Compounds; Thiocarbamates; Time Factors | 2000 |
Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.
Topics: Acetylcysteine; Animals; Cysteine; Female; Follicle Stimulating Hormone; gamma-Glutamyltransferase; Growth Disorders; Growth Hormone; Infertility, Female; Infertility, Male; Insulin-Like Growth Factor I; Male; Mice; Mice, Knockout; Oligospermia; Ovarian Follicle; Ovary; Reproduction; Seminal Vesicles; Testis | 2000 |
Cataract development in gamma-glutamyl transpeptidase-deficient mice.
Topics: Acetylcysteine; Animals; Cataract; Cysteine; Electrophoresis; Free Radical Scavengers; gamma-Glutamyltransferase; Glutathione; Lighting; Mice; Mice, Inbred C57BL | 2000 |
Configuration of thiols dictates their ability to promote iron-induced reactive oxygen species generation.
Topics: Acetylcysteine; Animals; Antioxidants; Cerebral Cortex; Cysteine; Glutathione; Homocysteine; Indicators and Reagents; Iron; Male; Mice; Mice, Inbred Strains; Mitochondria; Oxidation-Reduction; Reactive Oxygen Species; Structure-Activity Relationship; Sulfhydryl Compounds; Synaptosomes | 2000 |
Studies on a growth-inhibitory peptide derived from alpha-fetoprotein and some analogs.
Topics: Acetylcysteine; alpha-Fetoproteins; Animals; Antineoplastic Agents; Chromatography, Gel; Cysteine; Disulfides; Dose-Response Relationship, Drug; Epitopes; Estrogens; Female; Humans; Hydrogen-Ion Concentration; Mice; Peptide Biosynthesis; Peptides; Protein Structure, Tertiary; Time Factors; Uterus | 2001 |
Determination of reduced, protein-unbound, and total concentrations of N-acetyl-L-cysteine and L-cysteine in rat plasma by postcolumn ligand substitution high-performance liquid chromatography.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Ligands; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sulfhydryl Compounds | 2001 |
Restoration of the cellular thiol status of peritoneal macrophages from CAPD patients by the flavonoids silibinin and silymarin.
Topics: Acetylcysteine; Adult; Aged; Antigens, CD; Cells, Cultured; Coloring Agents; Cysteine; Female; Flow Cytometry; Fluoresceins; Gene Expression Regulation; Glutathione; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-6; Macrophages, Peritoneal; Male; Middle Aged; Oxidative Stress; Peritoneal Dialysis, Continuous Ambulatory; Phagocytosis; Sialoglycoproteins; Silymarin; Sulfhydryl Compounds | 2001 |
Glutathiolation of the proteasome is enhanced by proteolytic inhibitors.
Topics: Acetylcysteine; Animals; Base Sequence; Clone Cells; Cysteine; Cysteine Endopeptidases; DNA Primers; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; In Vitro Techniques; Lactones; Liver; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; RNA, Messenger; Sulfones | 2001 |
Carboxyl-methylation of Rab3D in the rat pancreatic acinar tumor cell line AR42J.
Topics: Acetylcysteine; Animals; Antibody Specificity; Cysteine; Dexamethasone; Diterpenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Isoelectric Focusing; Lovastatin; Methylation; Pancreas; Pancreatic Neoplasms; Protein Isoforms; Protein Methyltransferases; Protein Prenylation; rab3 GTP-Binding Proteins; rab3A GTP-Binding Protein; Rats; Subcellular Fractions; Tumor Cells, Cultured | 2001 |
Se-methylselenocysteine induces apoptosis mediated by reactive oxygen species in HL-60 cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Apoptosis; Blotting, Western; Caspases; Cell Survival; Cysteine; Cytochrome c Group; Enzyme Activation; Flow Cytometry; HeLa Cells; HL-60 Cells; Humans; Membrane Potentials; Organoselenium Compounds; Reactive Oxygen Species; Selenocysteine | 2001 |
Oxidation and generation of hydrogen peroxide by thiol compounds in commonly used cell culture media.
Topics: Acetylcysteine; Animals; Cattle; Cell Culture Techniques; Culture Media; Cysteamine; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Electrophysiology; Free Radical Scavengers; Glutathione; Homocysteine; Hydrogen Peroxide; Oxidation-Reduction; Sulfhydryl Compounds | 2001 |
Effect of iron and manganese on hydroxyl radical production by 6-hydroxydopamine: mediation of antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Corpus Striatum; Cysteine; Female; Glutathione; Hydrogen Peroxide; Hydroxyl Radical; Iron; Manganese; Oxidation-Reduction; Oxidopamine; Rats; Rats, Sprague-Dawley | 2001 |
Cysteine and mercapturate conjugates of oxidized dopamine are in human striatum but only the cysteine conjugate impedes dopamine trafficking in vitro and in vivo.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Animals; Brain; Cells, Cultured; Corpus Striatum; Cysteine; Dopamine; Esters; Female; Fetus; Humans; In Vitro Techniques; Male; Mesencephalon; Microdialysis; Nerve Degeneration; Oxidation-Reduction; Parkinson Disease; Rats; Rats, Sprague-Dawley; Synaptosomes | 2001 |
Cytoadherence of Plasmodium falciparum-infected erythrocytes is mediated by a redox-dependent conformational fraction of CD36.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; CD36 Antigens; Cell Adhesion; Cell Line; Chemical Fractionation; COS Cells; Cysteine; Dithiothreitol; Endothelium, Vascular; Epitopes; Erythrocyte Aggregation; Erythrocytes; Humans; Molecular Sequence Data; Oxidation-Reduction; Plasmodium falciparum; Protein Conformation; Reducing Agents; U937 Cells | 2001 |
Altered differentiation in rat and rabbit limb bud micromass cultures by glutathione modulating agents.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Differentiation; Cell Survival; Cells, Cultured; Chondrogenesis; Cysteine; Glutathione; Limb Buds; Malates; Oxidation-Reduction; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Staining and Labeling | 2001 |
Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acety
Topics: Acetylation; Acetylcysteine; Anesthetics, Inhalation; Biotransformation; Cysteine; Ethers; Free Radical Scavengers; Humans; Hydrocarbons, Fluorinated; Kidney; Lyases; Methyl Ethers; Sevoflurane | 2002 |
Oxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cells.
Topics: Acetylcysteine; Animals; Apoptosis; Catalase; Creatine Kinase; Cysteine; Dopamine; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen Peroxide; Isoenzymes; Nerve Tissue Proteins; Oxidation-Reduction; Parkinson Disease; PC12 Cells; Phospholipase C gamma; Protein Disulfide-Isomerases; Protein Isoforms; Rats; Thioredoxin-Disulfide Reductase; Type C Phospholipases | 2002 |
Glutathione and mercapturic acid conjugates of sulofenur and their activity against a human colon cancer cell line.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Bile; Cell Division; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cysteine; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Glutathione; Glutathione Reductase; Humans; Magnetic Resonance Spectroscopy; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonylurea Compounds; Tumor Cells, Cultured | 2002 |
Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization.
Topics: Acetylcysteine; Adjuvants, Immunologic; Administration, Inhalation; Aerosols; Animals; Antioxidants; Cell Line; Cysteine; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Lipid Peroxidation; Lung; Mice; Ovalbumin; Oxidative Stress; Sulfhydryl Compounds; Vehicle Emissions | 2002 |
Reactions of purines-containing butenolides with L-cysteine or N-acetyl-L-cysteine as model biological nucleophiles: a potent mechanism-based inhibitor of ribonucleotide reductase caused apoptosis in breast carcinoma MCF7 cells.
Topics: 4-Butyrolactone; Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line; Cysteine; Cytarabine; Dose-Response Relationship, Drug; Escherichia coli; Fibroblasts; Furans; Humans; Mice; Molecular Structure; Purines; Ribonucleotide Reductases; Sulfhydryl Compounds; Tumor Cells, Cultured | 2002 |
Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Electrochemistry; Electrodes; Glutathione; Gold; HL-60 Cells; Humans; Sensitivity and Specificity; Spectrophotometry; Sulfhydryl Compounds | 2002 |
Oxygen-induced pulmonary injury in gamma-glutamyl transpeptidase-deficient mice.
Topics: Acetylcysteine; Animals; Cysteine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Hyperoxia; Lung; Lung Injury; Mice; RNA | 2001 |
Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells.
Topics: Acetylcysteine; Antigens, Polyomavirus Transforming; Aorta; Cell Line, Transformed; Cell Survival; Cysteine; Diterpenes; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Intercellular Adhesion Molecule-1; Methylation; Protein Methyltransferases; rac1 GTP-Binding Protein; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
Renal organic anion transport system: a mechanism for the basolateral uptake of mercury-thiol conjugates along the pars recta of the proximal tubule.
Topics: Acetylcysteine; Animals; Cysteine; Female; Glutathione; In Vitro Techniques; Ion Transport; Kidney Tubules, Proximal; Mercury; Organic Anion Transporters; p-Aminohippuric Acid; Rabbits; Specific Pathogen-Free Organisms | 2002 |
A putative role for S-nitrosoglutathione as the source of nitric oxide in photorelaxation of the mouse gastric fundus.
Topics: Acetylcysteine; Animals; Cysteine; Diamide; Enzyme Inhibitors; Ethacrynic Acid; Female; Gastric Fundus; Glutathione; In Vitro Techniques; Isoproterenol; Male; Mice; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; S-Nitrosoglutathione; S-Nitrosothiols; Ultraviolet Rays | 2002 |
Nonenzymatic antioxidant activity of four organosulfur compounds derived from garlic.
Topics: Acetylcysteine; Allyl Compounds; alpha-Tocopherol; Antioxidants; Cysteine; Disulfides; Garlic; Hydrogen-Ion Concentration; Lipid Peroxidation; Sulfides; Sulfur Compounds | 2002 |
Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.
Topics: Acetylcysteine; Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Cysteine; Disease Models, Animal; gamma-Glutamyltransferase; Glutathione; Inflammation; Leukocyte Count; Matrix Metalloproteinase 9; Mice; Mice, Inbred Strains; Neutrophils; Pulmonary Fibrosis; Severity of Illness Index; Time Factors | 2003 |
Antioxidant requirements for bovine oocytes varies during in vitro maturation, fertilization and development.
Topics: Acetylcysteine; Animals; Antioxidants; Blastocyst; Catalase; Cattle; Cells, Cultured; Culture Media; Cysteine; Embryonic and Fetal Development; Fertilization in Vitro; Free Radical Scavengers; Morula; Oocytes; Reactive Oxygen Species; Superoxide Dismutase | 2003 |
Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.
Topics: Acetylcysteine; Adenosine; Animals; Apoptosis; Cattle; Cells, Cultured; Cysteine; Diterpenes; Endothelium, Vascular; Enzyme Inhibitors; Mitogen-Activated Protein Kinases; Protein Methyltransferases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; ras Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Ultraviolet Rays | 2003 |
Modulation of extracellular homocysteine concentration in human cell lines.
Topics: Acetylcysteine; Amino Acid Transport Systems; Carcinoma, Hepatocellular; Copper; Cysteine; Dithiothreitol; Extracellular Fluid; HeLa Cells; Homocysteine; Humans; Oxidation-Reduction; Sulfhydryl Compounds; Sulfonic Acids; Tumor Cells, Cultured | 2003 |
Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols.
Topics: Acetylcysteine; Amifostine; Animals; Cell Line; Cysteine; Disulfiram; Dithiothreitol; Lipopolysaccharides; Macrophages; Mercaptoethylamines; Mice; Nitric Oxide; Radiation-Protective Agents; Sulfhydryl Compounds | 2003 |
Maturation-dependent thiol loss increases chondrocyte susceptibility to apoptosis.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Apoptosis; Buthionine Sulfoximine; Cell Differentiation; Cell Survival; Cells, Cultured; Chick Embryo; Chondrocytes; Collagen Type II; Collagen Type IX; Cysteine; Fluorescent Dyes; Gene Expression; Glutathione; Growth Plate; Nitric Oxide; Osteopontin; Oxidation-Reduction; Oxidative Stress; Sialoglycoproteins; Sulfhydryl Compounds; Tretinoin | 2003 |
Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Free Radical Scavengers; Glutathione; Mice; Prodrugs | 2003 |
Protective action on human LDL against oxidation and glycation by four organosulfur compounds derived from garlic.
Topics: Acetylcysteine; Allyl Compounds; Amphotericin B; Antioxidants; Chelating Agents; Copper; Cysteine; Disulfides; Edetic Acid; Garlic; Glucose; Humans; Lipoproteins, LDL; Oxidation-Reduction; Sulfides; Sulfur Compounds; Superoxides; Xanthine Oxidase | 2003 |
Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.
Topics: Acetylcysteine; Animals; Bone Diseases, Metabolic; Chondrocytes; Cysteine; Free Radical Scavengers; gamma-Glutamyltransferase; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glutathione; Growth Plate; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoblasts; Spine; Tibia | 2003 |
2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Transformed; Cell Transformation, Viral; Cysteine; Deoxyglucose; Dose-Response Relationship, Drug; Fibroblasts; Free Radicals; Genes, fos; Glucose; Glutathione; HeLa Cells; Humans; Oncogene Proteins v-fos; Oxidation-Reduction; Oxidative Stress; Radiation-Protective Agents; Radiation-Sensitizing Agents; Rats; Sulfhydryl Compounds; Tumor Stem Cell Assay | 2003 |
Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Indolequinones; Magnetic Resonance Spectroscopy; Monophenol Monooxygenase; Oxidation-Reduction; Quercetin; Quinones; Sulfhydryl Compounds | 2003 |
A drug to prevent renal failure?
Topics: Acetylcysteine; Acute Kidney Injury; Contrast Media; Cysteine; Humans; Kidney Failure, Chronic; Meta-Analysis as Topic; Terminology as Topic | 2003 |
[Effect of vitamin B6 deficiency on formation of mercapturic acid and on transulfuration in the rat organism].
Topics: Acetylcysteine; Animals; Biochemical Phenomena; Cysteine; Rats; Sulfur; Vitamin B 6 Deficiency | 1953 |
The metabolism of pentachloronitrobenzene and 2:3:4:6-tetrachloronitrobenzene and the formation of mercapturic acids in the rabbit.
Topics: Acetylcysteine; Animals; Cysteine; Nitrobenzenes; Rabbits | 1955 |
Mercapturic acid precursors.
Topics: Acetylcysteine; Cysteine | 1956 |
The metabolism of 2:3-, 2:6- and 3:5-dichloronitrobenzene and the formation of a mercapturic acid from 2:3:4:5-tetrachloronitro-benzene in the rabbit.
Topics: Acetylcysteine; Animals; Benzene; Cysteine; Nitrobenzenes; Rabbits | 1957 |
Biochemical studies of toxic agents. 10. Observations on the metabolism of 35S-labelled mercapturic acids.
Topics: Acetylcysteine; Cysteine | 1958 |
The formation of mercapturic acids. 1. Formation of mercapturic acid and the levels of glutathione in tissues.
Topics: Acetylcysteine; Cysteine; Glutathione | 1959 |
The formation of mercapturic acids. 2. The possible role of glutathionase.
Topics: Acetylcysteine; Cysteine; Endopeptidases; Hydrolases; Peptide Hydrolases | 1959 |
The formation of mercapturic acids. 3. N-Acetylation of S-substituted cysteines in the rabbit, rat and guinea pig.
Topics: Acetylation; Acetylcysteine; Animals; Cysteine; Guinea Pigs; Rabbits; Rats | 1959 |
The formation of mercapturic acids. 4. Deacetylation of mercapturic acids by the rabbit, rat and guinea pig.
Topics: Acetylcysteine; Animals; Cell Physiological Phenomena; Cysteine; Guinea Pigs; Rabbits; Rats | 1960 |
Mercapturic acids from tissue proteins.
Topics: Acetylcysteine; Cysteine; Intestinal Mucosa; Liver; Proteins | 1959 |
Sputum digestion and decontamination with N-acetyl-L-cysteine-sodium hydroxide for culture of mycobacteria.
Topics: Acetylcysteine; Bacteriological Techniques; Cysteine; Decontamination; Hydroxides; Mycobacterium; Sodium Hydroxide; Sputum | 1963 |
The effect of N-acetylcysteine on the viscosity of tracheobronchial secretions in cystic fibrosis of the pancreas.
Topics: Acetylcysteine; Bronchi; Cysteine; Cystic Fibrosis; Humans; Trachea; Viscosity | 1963 |
The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-acetyl-L-cysteine.
Topics: Acetylcysteine; Cysteine; Expectorants; In Vitro Techniques; Mucoproteins; Sulfhydryl Compounds; Viscosity | 1963 |
Acetylcysteine, a new and effective mucolytic agent.
Topics: Acetylcysteine; Bronchi; Cysteine; Cystic Fibrosis; Expectorants; Humans; Lung Diseases | 1963 |
Studies on mercapturic acid synthesis by humans.
Topics: Acetylcysteine; Bromides; Cysteine; Humans; Sulfhydryl Compounds | 1963 |
Clinical evaluaton of a new mucolytic agent, acetyl-cysteine.
Topics: Acetylcysteine; Bronchi; Bronchial Diseases; Cysteine; Disease; Expectorants; Humans; Lung Abscess | 1962 |
The fate of mercapturic acids in the animal body.
Topics: Acetylcysteine; Animals; Cysteine; Humans | 1962 |
THE USE OF N-ACETYLCYSTEINE IN THE TREATMENT OF CYSTIC FIBROSIS.
Topics: Acetylcysteine; Adolescent; Child; Cysteine; Cystic Fibrosis; Expectorants; Humans; Lung Diseases; Respiration; Respiratory Therapy | 1963 |
COMMENTS ON THE USE OF THE NEW MUCOLYTIC AGENT, N-ACETYL-L-CYSTEINE, AS A SPUTUM DIGESTANT FOR THE ISOLATION OF MYCOBACTERIA.
Topics: Acetylcysteine; Bacteriological Techniques; Cysteine; Expectorants; Gastrointestinal Agents; Humans; Mycobacterium; Sputum | 1964 |
[EFFECTS OF THE AEROSOL ADMINISTRATION OF N-ACETYL-L-CYSTEINE COMBINED WITH A TETRACYCLINE ON THE PHYSICAL CHARACTERISTICS OF BRONCHIAL SECRETIONS AND SUBJECTIVE SYMPTOMS IN CHRONIC BRONCHITIS].
Topics: Acetylcysteine; Aerosols; Anti-Bacterial Agents; Bronchi; Bronchitis; Bronchitis, Chronic; Cysteine; Humans; Pharmacology; Tetracycline | 1963 |
SUCCESSFUL TREATMENT WITH THE MUCOLYTIC AGENT ACETYLCYSTEINE.
Topics: Acetylcysteine; Arrhythmia, Sinus; Arrhythmias, Cardiac; Cysteine; Expectorants; Female; Kartagener Syndrome; Meperidine; Ophthalmoplegia; Paranasal Sinuses; Pregnancy; Pregnancy Complications; Promazine; Pupil; Radiography, Thoracic; Respiratory Insufficiency; Scopolamine; Sinusitis; Toxicology | 1964 |
[ACTION "IN VITRO" OF N-ACETYL-L-CYSTEINE AND OF CHYMOTRYPSIN ON VISCOSITY OF BRONCHIAL SECRETIONS].
Topics: Acetylcysteine; Bronchitis; Chymotrypsin; Cysteine; Humans; In Vitro Techniques; Mucoproteins; Sputum; Viscosity | 1964 |
CLINICAL EXPERIENCES WITH ACETYLCYSTEINE AS A MUCOLYTIC AGENT.
Topics: Acetylcysteine; Bronchial Diseases; Cysteine; Expectorants; Humans; Postoperative Complications | 1964 |
MECONIUM ILEUS.
Topics: Acetylcysteine; Child; Cysteine; Cystic Fibrosis; Diagnosis; Humans; Ileus; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Intussusception; Meconium; Pancreatic Extracts; Rectal Prolapse; Surgical Procedures, Operative | 1964 |
THE IN VITRO REDUCTION IN VISCOSITY OF HUMAN TRACHEOBRONCHIAL SECRETIONS BY ACETYLCYSTEINE.
Topics: Acetates; Acetylcysteine; Bronchitis; Chemistry Techniques, Analytical; Cysteine; Expectorants; Humans; In Vitro Techniques; Lung Diseases; Pharmacology; Pulmonary Emphysema; Ribonucleases; Sputum; Viscosity | 1964 |
IATROGENIC BRONCHOSPASM OCCURRING DURING CLINICAL TRIALS OF A NEW MUCOLYTIC AGENT, ACETYLCYSTEINE.
Topics: Acetylcysteine; Aerosols; Asthma; Bronchial Spasm; Cysteine; Drug Therapy; Expectorants; Humans; Iatrogenic Disease; Toxicology | 1964 |
NEW MUCOLYTIC AGENTS FOR SPUTUM LIQUEFACTION.
Topics: Acetylcysteine; Asthma; Bronchial Diseases; Cysteine; Cystic Fibrosis; Expectorants; Fibrin; Humans; Lung Diseases; Mucus; Sputum; Toxicology | 1964 |
ACETYLCYSTEINE USED TO LIQUEFY INSPISSATED MECONIUM CAUSING INTESTINAL OBSTRUCTION IN THE NEWBORN.
Topics: Acetylcysteine; Cysteine; Cystic Fibrosis; Fetal Diseases; Hernia, Umbilical; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Intestinal Perforation; Meconium; Peritonitis; Surgical Procedures, Operative | 1964 |
THE USE OF N-ACETYLCYSTEINE IN THE TREATMENT OF CYSTIC FIBROSIS.
Topics: Acetylcysteine; Adolescent; Child; Cysteine; Cystic Fibrosis; Humans; Infant; Klebsiella; Lung Diseases; Pneumonia; Proteus Infections; Pseudomonas Infections; Pulmonary Emphysema; Radiography, Thoracic; Respiratory Function Tests; Respiratory Therapy; Spirometry; Staphylococcal Infections | 1964 |
INHALATION THERAPY.
Topics: Acetylcysteine; Anti-Bacterial Agents; Bronchial Spasm; Cysteine; Drug Therapy; Epinephrine; Equipment and Supplies; Humans; Hypoxia; Isoproterenol; Mucus; Oxygen Inhalation Therapy; Phenylephrine; Propylene Glycols; Respiratory Therapy; Respiratory Tract Diseases | 1965 |
N.A.C. AND ANTIBIOTICS IN CYSTIC FIBROSIS.
Topics: Acetylcysteine; Ampicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Cysteine; Cystic Fibrosis; Erythromycin; Fusidic Acid; Humans; Penicillins; Pharmacology; Protein Synthesis Inhibitors; Tetracycline | 1965 |
N-ACETYL-L-CYSTEINE AS LIQUEFYING AGENT IN THE BACTERIOLOGICAL EXAMINATION OF SPUTUM.
Topics: Acetylcysteine; Bacteriological Techniques; Culture Media; Cysteine; Enterobacteriaceae; Haemophilus; Humans; Mycobacterium; Pharmacology; Pseudomonas; Sputum; Staphylococcus; Yeasts | 1964 |
A NEWER SOLVENT FOR URINARY CALCULI: IN VITRO STUDY.
Topics: Acetylcysteine; Chemical Phenomena; Chemistry; Citrates; Cysteine; In Vitro Techniques; Research; Solvents; Urinary Calculi | 1965 |
CLINICAL EVALUATION OF ACETYLCYSTEINE AS A MUCOLYTIC AGENT IN CYSTIC FIBROSIS.
Topics: Acetylcysteine; Adolescent; Aerosols; Blood Gas Analysis; Child; Cysteine; Cystic Fibrosis; Drug Therapy; Expectorants; Humans; Respiratory Function Tests | 1965 |
A NEW MUCOLYTIC AGENT AS A THERAPEUTIC ADJUNCT IN NASAL SINUSITIS.
Topics: Acetylcysteine; Cysteine; Expectorants; Humans; Mucus; Nose; Sinusitis; Therapeutic Irrigation; Toxicology | 1965 |
METHODS OF DIMINISHING CYSTINE EXCRETION IN CYSTINURIA.
Topics: Acetylcysteine; Amino Acids; Cysteine; Cystine; Cystinuria; Diet; Diet Therapy; Drug Therapy; Fluids and Secretions; Indoles; Oxandrolone; Penicillamine; Rats; Sulfur; Vitamin B 6 Deficiency | 1965 |
A COMPARISON BETWEEN PANCREATIN AND N-ACETYL-L-CYSTEINE AS SPUTUM LIQUEFYING AGENTS FOR THE CULTURE OF ORGANISMS.
Topics: Acetylcysteine; Bacteria; Bacteriological Techniques; Culture Media; Cysteine; Haemophilus; Pancreatic Extracts; Pancreatin; Research; Sputum; Yeasts | 1965 |
METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 9,10-EPOXY-9,10-DIHYDROPHENANTHRENE IN RATS.
Topics: Acetylcysteine; Animals; Chromatography; Cysteine; Epoxy Compounds; Ethers; Ethers, Cyclic; Glutathione; Metabolism; Phenanthrenes; Polycyclic Compounds; Rabbits; Rats; Research | 1965 |
N-ACYLATION OF CYSTEINE.
Topics: Acetylcysteine; Acylation; Chemical Phenomena; Chemistry; Cysteine; Research | 1965 |
[A NEW MUCOLYTIC: N-ACETYL-L-CYSTEINE IN PRE-AND POSTOPERATIVE TREATMENT OF PATIENTS IN THORACIC SURGERY].
Topics: Acetylcysteine; Cysteine; Expectorants; Humans; Postoperative Care; Preoperative Care; Thoracic Diseases; Thoracic Surgery | 1965 |
The structure of the mercapturic acids formed in rabbits from trichlorobenzenes.
Topics: Acetylcysteine; Animals; Benzene; Benzene Derivatives; Chlorobenzenes; Cysteine; Rabbits | 1955 |
Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content.
Topics: Acetylcysteine; Animals; Cysteine; Dietary Proteins; Glucose; Glutathione; Kinetics; Lactalbumin; Liver; Male; Milk Proteins; Myocardium; Oxidation-Reduction; Physical Exertion; Rats; Rats, Wistar | 2004 |
Five cysteine-containing compounds have antioxidative activity in Balb/cA mice.
Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cholesterol; Cysteine; Fibronectins; Garlic; Glutathione; Glutathione Peroxidase; Kidney; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred BALB C; Triglycerides | 2004 |
Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers.
Topics: Acetylcysteine; Antigen-Presenting Cells; Antioxidants; Cells, Cultured; Cysteine; Dermatitis, Contact; Glutathione; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Picryl Chloride; Sulfhydryl Compounds; Tyrosine | 2003 |
The role of a formaldehyde dehydrogenase-glutathione pathway in protein S-nitrosation in mammalian cells.
Topics: Acetylcysteine; Aldehyde Oxidoreductases; Animals; Buthionine Sulfoximine; Cells, Cultured; Cysteine; Dehydroepiandrosterone; Glutathione; Glutathione Reductase; HeLa Cells; Humans; Mice; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitrosation; Proteins; RNA, Small Interfering; S-Nitrosoglutathione; S-Nitrosothiols | 2003 |
Metabolism of benzene; excretion of phenylsulphuric acid after administration of phenylmercapturic acid and phenylcysteine.
Topics: Acetylcysteine; Benzene; Cysteine | 1951 |
Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Cysteine; Cytochrome P-450 Enzyme System; Ethers; Humans; Hydrocarbons, Fluorinated; Kidney; Methyl Ethers; Microsomes, Liver; Oxidation-Reduction; Rats; Sevoflurane; Sulfoxides | 2004 |
Systemic administration of N-acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration.
Topics: Acetylcysteine; Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Ascorbic Acid; Avian Proteins; Basigin; Blood Proteins; Cell Count; Corpus Striatum; Cysteine; Dopamine; Drug Administration Routes; Female; Fluoresceins; Fluorescent Dyes; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxydopamines; Immunohistochemistry; Membrane Glycoproteins; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2004 |
N-acetyl-cysteine in the prevention of vascular restenosis after percutaneous balloon angioplasty.
Topics: Acetylcysteine; Angioplasty, Balloon; Animals; Cysteine; Free Radical Scavengers; Glutathione; Iliac Artery; Immunohistochemistry; Prospective Studies; Rabbits; Vascular Patency | 2004 |
Redox state regulates HIF-1alpha and its DNA binding and phosphorylation in salmonid cells.
Topics: Acetylcysteine; Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cell Line; Cysteine; Dimerization; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Oncorhynchus mykiss; Oxidation-Reduction; Oxidative Stress; Oxygen; Phosphorylation; Proline; Propyl Gallate; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; RNA; Time Factors; Transcription Factors; Transcriptional Activation | 2004 |
Diallyl disulfide, a chemopreventive agent in garlic, induces multidrug resistance-associated protein 2 expression.
Topics: Acetylcysteine; Allyl Compounds; Animals; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Membrane; Cisplatin; Cysteine; Disulfides; Garlic; Glutathione; Glutathione Transferase; Kidney; Kidney Cortex; Liver; Male; Microvilli; Mitochondrial Proteins; Plant Extracts; Protein Isoforms; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins | 2004 |
Five cysteine-containing compounds delay diabetic deterioration in Balb/cA mice.
Topics: Acetylcysteine; Animals; Blood Glucose; Body Weight; Catalase; Cysteine; Diabetes Mellitus; Glutathione; Glutathione Peroxidase; Kidney; Liver; Male; Mice; Mice, Inbred BALB C | 2004 |
N-acetyl cysteine, L-cysteine, and beta-mercaptoethanol augment selenium-glutathione peroxidase activity in glucose-6-phosphate dehydrogenase-deficient human erythrocytes.
Topics: Acetylcysteine; Adolescent; Case-Control Studies; Child; Child, Preschool; Cysteine; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione Peroxidase; Humans; Male; Mercaptoethanol | 2004 |
Biologically important thiols in various vegetables and fruits.
Topics: Acetylcysteine; Captopril; Chromatography, High Pressure Liquid; Cysteine; Fruit; Homocysteine; Sulfhydryl Compounds; Vegetables | 2004 |
Effect of five cysteine-containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet.
Topics: Acetylcysteine; Animals; Blood Glucose; Cysteine; Diet; Dietary Fats; Fatty Acid Synthases; Fatty Acids; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Hyperlipidemias; Insulin; Kidney; Liver; Malate Dehydrogenase; Male; Mice; Mice, Inbred BALB C; Myocardium; Uric Acid | 2004 |
Synthesis, characterization, and controlled nitric oxide release from S-nitrosothiol-derivatized fumed silica polymer filler particles.
Topics: Acetylcysteine; Biocompatible Materials; Copper; Cysteine; Nitric Oxide; Nitric Oxide Donors; Particle Size; Penicillamine; Photochemistry; Platelet Aggregation Inhibitors; Polymers; S-Nitrosothiols; Silicon Dioxide | 2005 |
A pulsed potential waveform displaying enhanced detection capabilities towards sulfur-containing compounds at a gold working electrode.
Topics: Acetylcysteine; Biotin; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cysteine; Cystine; Electrochemistry; Electrodes; Glutathione; Gold; Homocysteine; Methionine; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity; Sulfur Compounds; Thioctic Acid | 2005 |
Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Biomarkers, Tumor; Blotting, Western; Cysteine; DNA-Binding Proteins; DNA, Complementary; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Genes, Dominant; Glutathione S-Transferase pi; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lactones; Leupeptins; Luciferases; Mice; NF-E2-Related Factor 2; Oligonucleotides, Antisense; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Time Factors; Trans-Activators; Transfection; Up-Regulation | 2005 |
Enzymatic method with polyphenol oxidase for the determination of cysteine and N-acetylcysteine.
Topics: Acetylcysteine; Agaricales; Catechol Oxidase; Cysteine; Kinetics; Magnetic Resonance Spectroscopy; Spectrophotometry; Sulfhydryl Compounds | 2005 |
Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth.
Topics: Acetylcysteine; Amino Acid Transport Systems; Animals; Cell Membrane; Cysteine; Cytoplasmic Vesicles; Dose-Response Relationship, Drug; Glutathione; Ion Transport; Kidney Tubules, Proximal; Male; Mercury; Nephrectomy; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Regeneration | 2005 |
Separation and quantification of N-acetyl-l-cysteine and N-acetyl-cysteine-amide by HPLC with fluorescence detection.
Topics: Acetylcysteine; Amides; Animals; Chromatography, High Pressure Liquid; Cysteine; Fluorescence; Glutathione; Molecular Structure; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Fluorescence; Sulfhydryl Compounds; Tissue Distribution | 2006 |
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.
Topics: Acetylcysteine; Aging; Animals; Behavior, Animal; Bicuculline; Blotting, Western; Brain; Cysteine; Excitatory Amino Acid Transporter 3; GABA Antagonists; Genotype; Glutathione; Immunohistochemistry; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Oxidants; Oxidative Stress | 2006 |
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cysteine; Down-Regulation; Glutathione Transferase; Insulin-Like Growth Factor I; Liver Neoplasms; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Silver Staining; Time Factors | 2006 |
Brain protection at the blood-cerebrospinal fluid interface involves a glutathione-dependent metabolic barrier mechanism.
Topics: Acetylcysteine; Animals; Blood-Brain Barrier; Cerebrospinal Fluid; Choroid Plexus; Chromatography, High Pressure Liquid; Cysteine; Dinitrochlorobenzene; Epithelium; Glutathione; Glutathione Transferase; Humans; Irritants; Nerve Tissue Proteins; Neuroprotective Agents; Permeability; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2006 |
Ternary Cu(II) complexes, Cu(H(-1)L)(ACys-) and Cu(H(-2)L)(ACys-); L = peptides, ACys- = N-acetyl-cysteinate. Analogous complexes to the intermediates in the transport of Cu(II) from Cu(H(-2)L) to cysteine.
Topics: Acetylcysteine; Copper; Cysteine; Electron Spin Resonance Spectroscopy; Glycylglycine; Kinetics; Models, Chemical; Molecular Structure; Oligopeptides; Spectrophotometry, Ultraviolet; Thermodynamics | 2006 |
Silica-induced apoptosis in alveolar macrophages: evidence of in vivo thiol depletion and the activation of mitochondrial pathway.
Topics: Acetylcysteine; Alkaloids; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Benzylisoquinolines; Caspase 3; Caspases; Cysteine; Cytochromes c; Disease Models, Animal; Glutathione; Inflammation Mediators; Macrophages, Alveolar; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria; Oxidative Stress; Paclitaxel; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Silicon Dioxide; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha | 2006 |
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.
Topics: Acetylcysteine; Animals; Cell Membrane; Cysteine; Diterpenes; Enzyme Inhibitors; Mice; Mice, Knockout; Protein Methyltransferases; rab3 GTP-Binding Proteins; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Urinary mercapturic acids and a hemoglobin adduct for the dosimetry of acrylamide exposure in smokers and nonsmokers.
Topics: Acetylcysteine; Acrylamide; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Epoxy Compounds; Female; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Male; Nicotiana; Smoking; Valine | 2006 |
Effect of N-acetylcysteine, allopurinol and vitamin E on jaundice-induced brain oxidative stress in rats.
Topics: Acetylcysteine; Allopurinol; Animals; Antioxidants; Brain; Cysteine; Disease Models, Animal; Jaundice, Obstructive; Lipid Peroxidation; Male; Oxidation-Reduction; Oxidative Stress; Rats; Sulfhydryl Compounds; Treatment Outcome; Vitamin E | 2006 |
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Base Sequence; Biological Products; Blotting, Western; Cell Line, Tumor; Curcumin; Cysteine; DNA Modification Methylases; DNA Primers; DNA Repair Enzymes; Dose-Response Relationship, Drug; Fenretinide; Glutathione; Glutathione S-Transferase pi; Humans; Lymphocytes; Prodrugs; Pyrazines; RNA, Messenger; Silymarin; Thiones; Thiophenes; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins | 2007 |
Conserved actin cysteine residues are oxidative stress sensors that can regulate cell death in yeast.
Topics: Acetylcysteine; Actins; Amino Acid Sequence; Antioxidants; Conserved Sequence; Cysteine; Cytoskeleton; Disulfides; Mutation; NADPH Dehydrogenase; Oxidative Stress; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Oral N-acetyl-L-cysteine is a safe and effective precursor of cysteine.
Topics: Acetylcysteine; Administration, Oral; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Biological Availability; Chickens; Cysteine; Dose-Response Relationship, Drug; Male; Nutritional Requirements; Random Allocation; Weight Gain | 2007 |
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, Liquid; Cysteine; Humans; Imines; Microsomes, Liver; Models, Biological; Molecular Structure; Oligopeptides; Protein Binding; Rats; Reproducibility of Results; Serum Albumin; Tandem Mass Spectrometry | 2007 |
Globin s-propyl cysteine and urinary N-acetyl-S-propylcysteine as internal biomarkers of 1-bromopropane exposure.
Topics: Acetylcysteine; Air Pollutants, Occupational; Animals; Biomarkers; Cysteine; Environmental Monitoring; Female; Globins; Humans; Hydrocarbons, Brominated; Inhalation Exposure; Male; Occupational Exposure; Protein Binding; Rats; Rats, Wistar; Solvents | 2007 |
Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.
Topics: Acetylcysteine; Amino Acid Sequence; Binding Sites; Buthionine Sulfoximine; Camptothecin; Cell Line, Tumor; Cross-Linking Reagents; Cysteine; Diamide; DNA Damage; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutaral; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Models, Molecular; Oxidative Stress; Phosphorylation; Recombinant Proteins; Tandem Mass Spectrometry; tert-Butylhydroperoxide; Tumor Suppressor Protein p53 | 2007 |
Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients.
Topics: Acetylcysteine; Acrolein; Aged; Aryldialkylphosphatase; Cysteine; Female; Humans; Kidney Failure, Chronic; Lipoproteins, HDL; Male; Middle Aged; Renal Dialysis; Treatment Outcome | 2007 |
Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production.
Topics: Acetylcysteine; Carbon Radioisotopes; Cysteine; Glycopeptides; Inositol; Inositol Phosphates; Models, Biological; Molecular Structure; Mutation; Mycobacterium smegmatis; Pyruvic Acid | 2007 |
Effects of cysteine-containing compounds on biosynthesis of triacylglycerol and cholesterol and anti-oxidative protection in liver from mice consuming a high-fat diet.
Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cholesterol; Cysteine; Dietary Fats; Fatty Acid Synthases; Glutathione; Glutathione Peroxidase; Hydroxymethylglutaryl CoA Reductases; Lipid Metabolism; Liver; Malate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Sterol Regulatory Element Binding Proteins; Triglycerides | 2008 |
Formation of three N-acetyl-L-cysteine monoadducts and one diadduct by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with N-acetyl-L-cysteine at physiological conditions: chemical mechanisms and toxicological implications.
Topics: Acetylcysteine; Cross-Linking Reagents; Cysteine; Free Radical Scavengers; Kidney; Kidney Diseases; Sulfoxides | 2007 |
Chiral high-performance liquid chromatography analysis of alpha-amino acid mixtures using a novel SH reagent--N-R-mandelyl-L-cysteine and traditional enantiomeric thiols for precolumn derivatization.
Topics: Acetylcysteine; Amino Acids; Chromatography, High Pressure Liquid; Cysteine; Indoles; o-Phthalaldehyde; Stereoisomerism; Sulfhydryl Compounds; Sulfhydryl Reagents | 2007 |
Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation.
Topics: Acetylcysteine; Animals; Anoikis; Cell Adhesion; Cell Culture Techniques; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; DNA Methylation; Gene Expression Regulation; Glutathione; Homocysteine; Lipid Peroxidation; Melanocytes; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Sepharose; Superoxides; Trypsin | 2007 |
Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Aspartic Acid; Behavior, Animal; Cysteine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Transporter 1; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Hydroxamic Acids; In Vitro Techniques; Indazoles; Male; Mice; Mice, Inbred C57BL; Movement Disorders; MPTP Poisoning; Neuroprotective Agents; Oxidative Stress; Substantia Nigra | 2008 |
Formation of mercapturic acids by cystinuric and normal dogs.
Topics: Acetylcysteine; Acids; Animals; Body Fluids; Cysteine; Cystine; Dogs; Humans; Pyridoxine; Urine | 1949 |
Enhancing glutathione synthesis can decrease zinc-mediated toxicity.
Topics: Acetylcysteine; Cell Line; Cell Line, Tumor; Cysteine; Glutathione; Humans; Hydrocortisone; Methionine; Reducing Agents; Stereoisomerism; Up-Regulation; Zinc Compounds | 2008 |
Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Catalase; Cell Proliferation; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Malondialdehyde; Oxidative Stress; Radiation-Protective Agents | 2008 |
Radioprotectant and radiosensitizer effects on sterility of gamma-irradiated bone.
Topics: Acetylcysteine; Bacillus subtilis; Bone Matrix; Colony Count, Microbial; Cysteine; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Nitroimidazoles; Radiation Dosage; Radiation-Protective Agents | 2008 |
Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic beta-cells.
Topics: Acetylcysteine; Aldehydes; Amino Acid Transport System y+; Animals; Animals, Newborn; Biological Transport; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine; Fibroblasts; Gene Expression; Glutathione; Homeodomain Proteins; Humans; Hydrogen Peroxide; Insulin-Secreting Cells; Kinetics; Oxidative Stress; Protein Transport; Rats; Rats, Wistar; Trans-Activators | 2008 |
Effects of hydrogen peroxide treatment on thiol contents in fresh-cut asparagus (Asparagus officinalis) spears.
Topics: Acetylcysteine; Antioxidants; Asparagus Plant; Captopril; Cysteine; Disinfectants; Food Handling; Food Preservatives; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Nutritive Value; Oxidative Stress; Sulfhydryl Compounds | 2009 |
The synthesis of S-benzylthiopyruvic acid and its conversion to N-acetyl-S-benzyl-L-cysteine in the rat; unavailability of thiopyruvic acid to rats for growth purposes.
Topics: Acetylcysteine; Animals; Cysteine; Rats | 1948 |
Synthesis of S-benzyl-thiopyruvic acid and its conversion to N-acetyl-S-benzyl-L-cysteine in the rat.
Topics: Acetylcysteine; Acids; Animals; Cysteine; Rats | 1948 |
N-Acetyl-S-(1-carbamoyl-2-hydroxy-ethyl)-L-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: comparison with the simultaneously excreted other mercaptuic acids.
Topics: Acetylcysteine; Acrylamide; Carcinogens; Cysteine; Epoxy Compounds; Humans; Kinetics; Male; Molecular Structure; Oxidation-Reduction; Sensitivity and Specificity | 2009 |
Dopamine auto-oxidation aggravates non-apoptotic cell death induced by over-expression of human A53T mutant alpha-synuclein in dopaminergic PC12 cells.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Benzimidazoles; Cell Death; Chromatography, High Pressure Liquid; Cysteine; Dopamine; Enzyme Inhibitors; Flow Cytometry; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Humans; Monophenol Monooxygenase; Mutation; Nerve Growth Factor; Oxidation-Reduction; PC12 Cells; Rats; Tetrazolium Salts; Thiazoles; Transfection | 2009 |
Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery.
Topics: Acetylcysteine; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; Cysteine; Dendrimers; Drug Delivery Systems; Flow Cytometry; Glutathione; Hydrogen-Ion Concentration; Mice; Polyamines; Reactive Oxygen Species; Serum Albumin, Bovine | 2009 |
Polarized spectroscopic elucidation of N-acetyl-L-cysteine, L-cysteine, L-cystine, L-ascorbic acid and a tool for their determination in solid mixtures.
Topics: Acetylcysteine; Ascorbic Acid; Cysteine; Cystine; Molecular Structure; Spectrophotometry, Infrared; Spectrum Analysis, Raman | 2010 |
N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes.
Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; Catalase; Cell Line; Cell Survival; Cysteine; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Myocytes, Cardiac; Oxidative Stress; Reactive Oxygen Species; Time Factors | 2009 |
A novel role for vitamin B(12): Cobalamins are intracellular antioxidants in vitro.
Topics: Acetylcysteine; Antioxidants; Cell Line; Cell Survival; Cysteine; Glutathione; Homocysteine; Humans; Hydrogen Peroxide; Oxidative Stress; Reactive Oxygen Species; Vitamin B 12; Vitamin B Complex | 2009 |
N-acetylcysteineamide (NACA) prevents inflammation and oxidative stress in animals exposed to diesel engine exhaust.
Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cysteine; Glutathione; Histocytochemistry; L-Lactate Dehydrogenase; Macrophages, Alveolar; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidative Stress; Pneumonia; Vehicle Emissions | 2009 |
Role of N-acetylcysteine and cystine in glutathione synthesis in human erythrocytes.
Topics: Acetylcysteine; Adult; Cells, Cultured; Cysteine; Cystine; Erythrocytes; Female; Free Radical Scavengers; Glutathione; Humans; Male; Middle Aged | 2009 |
N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Antioxidants; Apoptosis; B-Lymphocytes; Baculoviral IAP Repeat-Containing 3 Protein; Caspases; Cell Line, Transformed; Cell Transformation, Neoplastic; Coumarins; Cysteine; Dose-Response Relationship, Drug; Down-Regulation; Fluorescent Dyes; Herpesvirus 4, Human; Humans; Inhibitor of Apoptosis Proteins; Jurkat Cells; Mitochondria; NF-kappa B; Oligopeptides; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tosylphenylalanyl Chloromethyl Ketone; Transcription, Genetic; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Quantitative interference by cysteine and N-acetylcysteine metabolites during the LC-MS/MS bioanalysis of a small molecule.
Topics: Acetylcysteine; Artifacts; Biotransformation; Chromatography, Liquid; Cysteine; Humans; Molecular Structure; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Urinalysis | 2009 |
Use of oral N-acetylcysteine for protection of melanocytic nevi against UV-induced oxidative stress: towards a novel paradigm for melanoma chemoprevention.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Anticarcinogenic Agents; Antioxidants; Cysteine; Female; Glutathione; Humans; Male; Melanoma; Middle Aged; Nevus, Pigmented; Oxidative Stress; Risk; Skin Neoplasms; Time Factors; Ultraviolet Rays | 2009 |
S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats.
Topics: Acetylcysteine; Actins; Alanine Transaminase; Animals; Anticarcinogenic Agents; Chemoprevention; Cysteine; Disease Models, Animal; Hepatic Stellate Cells; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Rats; Rats, Wistar; Serum; Sulfhydryl Compounds; Swine; Treatment Outcome | 2009 |
Local hindlimb antioxidant infusion does not affect muscle glucose uptake during in situ contractions in rat.
Topics: Acetylcysteine; AMP-Activated Protein Kinases; Animals; Antioxidants; Biological Transport; Blood Pressure; Cysteine; Cystine; Electric Stimulation; Glucose; Glutathione; Heart Rate; Hindlimb; Infusions, Intra-Arterial; Male; Muscle Contraction; Muscle Fatigue; Muscle Strength; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species; Regional Blood Flow; Time Factors; Tyrosine; Vascular Resistance | 2010 |
Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol.
Topics: Acetylcysteine; Amidohydrolases; Bacterial Proteins; Cell Survival; Cysteine; Enzyme Inhibitors; Glycopeptides; Indicators and Reagents; Inositol; Mycobacterium tuberculosis; NADH, NADPH Oxidoreductases; Naphthoquinones; Oxidation-Reduction; Structure-Activity Relationship; Substrate Specificity; Thioglucosides | 2010 |
Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids.
Topics: Acetyl Coenzyme A; Acetylation; Acetylcysteine; Acetyltransferases; Cell Line; Codon, Terminator; Cysteine; Cytosol; Endoplasmic Reticulum; Humans; Microscopy, Confocal; Mutation; Polymorphism, Single Nucleotide; Xenobiotics | 2010 |
Detection of protein adduction derived from styrene oxide to cysteine residues by alkaline permethylation.
Topics: Acetylcysteine; Animals; Cattle; Cysteine; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Methylation; Mice; Microsomes, Liver; Serum Albumin, Bovine; Temperature; Time Factors | 2010 |
Chiral self assembled monolayers as resolving auxiliaries in the crystallization of valine.
Topics: Acetylcysteine; Crystallization; Cysteine; Glutathione; Gold; Penicillamine; Solubility; Stereoisomerism; Valine | 2010 |
Derivatization of thiols under flow conditions using two commercially available propiolate esters.
Topics: Acetylcysteine; Captopril; Cysteine; Esters; Flow Injection Analysis; Hydrogen-Ion Concentration; Propionates; Solubility; Temperature | 2010 |
Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Anticarcinogenic Agents; Antioxidants; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Colorectal Neoplasms; Cysteine; DNA Breaks; DNA Mismatch Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Guanosine; Humans; Mismatch Repair Endonuclease PMS2; Morpholines; MutL Protein Homolog 1; Nuclear Proteins; Organoselenium Compounds; Piperidines; Protein Serine-Threonine Kinases; Pyrones; Reactive Oxygen Species; Selenocysteine; Sodium Selenite; Tumor Suppressor Proteins | 2010 |
Redox regulation of lipopolysaccharide-mediated sulfiredoxin induction, which depends on both AP-1 and Nrf2.
Topics: Acetylcysteine; Animals; Butylated Hydroxyanisole; Catalysis; Cell Line; Cysteine; Enzyme Induction; Free Radical Scavengers; Lipopolysaccharides; Macrophages; Membrane Glycoproteins; Mice; Mice, Knockout; Mutation; NADPH Oxidase 2; NADPH Oxidases; NF-E2-Related Factor 2; NF-kappa B; Onium Compounds; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Reactive Oxygen Species; Response Elements; Transcription Factor AP-1 | 2010 |
Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide.
Topics: Acetamides; Acetylcysteine; Acrylamide; Adult; Amides; Analytic Sample Preparation Methods; Carcinogens; Cysteine; Deuterium; Epoxy Compounds; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Indicators and Reagents; Male; Organosilicon Compounds; Oxidation-Reduction; Silanes; Sulfoxides; Trifluoroacetic Acid | 2011 |
Measurement of S-methylcysteine and S-methyl-mercapturic acid in human urine by alkyl-chloroformate extractive derivatization and isotope-dilution gas chromatography-mass spectrometry.
Topics: Acetylcysteine; Adult; Biomarkers; Calibration; Cysteine; Female; Formates; Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Male; Methylhistidines; Reproducibility of Results; Sensitivity and Specificity | 2011 |
Glutathione modulates the toxicity of, but is not a biologically relevant reductant for, the Pseudomonas aeruginosa redox toxin pyocyanin.
Topics: Acetylcysteine; Cell Division; Cells, Cultured; Cysteine; Electron Spin Resonance Spectroscopy; Glutathione; Humans; NADP; Oxidation-Reduction; Pseudomonas aeruginosa; Pyocyanine; Reactive Oxygen Species | 2011 |
S-allylmercapto-N-acetylcysteine up-regulates cellular glutathione and protects vascular endothelial cells from oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Cattle; Cells, Cultured; Cysteine; Cytoprotection; Disulfides; Endothelial Cells; Glutathione; Metabolic Detoxication, Phase II; NF-E2-Related Factor 2; Oxidative Stress; Sulfinic Acids; tert-Butylhydroperoxide; Transcriptional Activation; Up-Regulation | 2011 |
Characterization of short-lived electrophilic metabolites of the anticancer agent laromustine (VNP40101M).
Topics: Acetylcysteine; Antineoplastic Agents; Carbon Isotopes; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Humans; Hydrazines; Magnetic Resonance Spectroscopy; Microsomes, Liver; NADP; Neoplasms; Spectrometry, Mass, Electrospray Ionization; Sulfonamides | 2011 |
Effect of N-acetyl-cysteine on liposomal and muscle model oxidation induced by reactive oxygen, nitrogen, and sulfur.
Topics: Acetylcysteine; Animals; Antioxidants; Cysteine; Food Additives; Food Handling; Free Radicals; Glutathione; Lipid Peroxidation; Lipid Peroxides; Liposomes; Meat; Models, Biological; Muscle, Skeletal; Oxidation-Reduction; Reactive Nitrogen Species; Reactive Oxygen Species; Sulfur; Thiobarbituric Acid Reactive Substances; Turkeys | 2011 |
Direct detection of biologically significant thiols and disulfides with manganese(IV) chemiluminescence.
Topics: Acetylcysteine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Cystine; Disulfides; Female; Glutathione; Glutathione Disulfide; Homocysteine; Homocystine; Humans; Luminescent Measurements; Male; Manganese; Oxidative Stress; Sulfhydryl Compounds; Young Adult | 2011 |
Hydrogen peroxide targets the cysteine at the active site and irreversibly inactivates creatine kinase.
Topics: Acetylcysteine; Anilino Naphthalenesulfonates; Binding Sites; Brain; Catalytic Domain; Creatine Kinase, BB Form; Cysteine; Dithionitrobenzoic Acid; Dithiothreitol; Glutathione; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Protein Binding; Reactive Oxygen Species; Spectrometry, Fluorescence; Structure-Activity Relationship; Sulfhydryl Compounds | 2011 |
N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo.
Topics: 3T3-L1 Cells; Acetylcysteine; Animals; Cysteine; Diabetes Mellitus, Type 2; Glucose; Homeostasis; Hypoglycemic Agents; Ligands; Mice; Mice, Knockout; PPAR gamma; Protein Binding; Rosiglitazone; Thiazolidinediones | 2011 |
Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules.
Topics: Acetylcysteine; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cysteine; Dose-Response Relationship, Drug; Glutathione; Humans; Maleimides; Models, Molecular; Molecular Structure; Organometallic Compounds; Ruthenium; Structure-Activity Relationship; Sulfhydryl Compounds | 2012 |
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Topics: Acetylcysteine; Amino Acid Substitution; Animals; Antioxidants; Cell Line; Cell Line, Tumor; Cell Survival; Cysteine; Diamide; Enzyme Activators; Glucose; Glutathione; Humans; Mice; Mice, Nude; Mutant Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Protein Subunits; Pyruvate Kinase; Reactive Oxygen Species; Transplantation, Heterologous | 2011 |
Cystathionine beta-synthase deficiency causes fat loss in mice.
Topics: Absorptiometry, Photon; Acetylcysteine; Animals; Blotting, Western; Body Mass Index; Body Weight; Cystathionine beta-Synthase; Cysteine; Fats; Female; Glutathione; Male; Mice; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Stearoyl-CoA Desaturase | 2011 |
Improved RP-HPLC separation of Hg²⁺ and CH₃Hg⁺ using a mixture of thiol-based mobile phase additives.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine; Mercury; Methylmercury Compounds; Spectrophotometry, Atomic; Water Pollutants, Chemical | 2012 |
Red blood cells protect albumin from cigarette smoke-induced oxidation.
Topics: Acetylcysteine; Cysteine; Cytoprotection; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocytes; Glutathione; Humans; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Serum Albumin; Smoke; Smoking; Sulfhydryl Compounds | 2012 |
Detoxification of toxins by bacillithiol in Staphylococcus aureus.
Topics: Acetylcysteine; Acetyltransferases; Amidohydrolases; Bridged Bicyclo Compounds; Cysteine; Glucosamine; Pyrazoles; Rifamycins; Sequence Deletion; Staphylococcus aureus; Sulfhydryl Compounds | 2012 |
Voltammetric determination of cysteine using carbon paste electrode modified with Co(II)-Y zeolite.
Topics: Acetylcysteine; Carbon; Cobalt; Cysteine; Electrochemistry; Electrodes; Humans; Hydrogen-Ion Concentration; Limit of Detection; Oxidation-Reduction; Reproducibility of Results; Tablets; Zeolites | 2012 |
Enhanced detection of hydrogen sulfide generated in cell culture using an agar trap method.
Topics: Acetylcysteine; Agar; Biological Assay; Cells, Cultured; Cystathionine gamma-Lyase; Cysteine; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Sulfide; Spectrophotometry, Ultraviolet; Sulfites | 2012 |
Luminal transport of thiol S-conjugates of methylmercury in isolated perfused rabbit renal proximal tubules.
Topics: Acetylcysteine; Animals; Biological Transport; Cysteine; Female; Glutathione; In Vitro Techniques; Isoxazoles; Kidney Tubules, Proximal; Methylmercury Compounds; Rabbits; Unithiol | 2012 |
Interaction of N-acetylcysteine and cysteine in human plasma.
Topics: Acetylcysteine; Antioxidants; Blood Proteins; Chromatography, High Pressure Liquid; Cysteine; Humans; Mass Spectrometry; Protein Binding | 2012 |
Detection and characterization of urinary metabolites of boldione by LC-MS/MS. Part II: Conjugates with cysteine and N-acetylcysteine.
Topics: Acetylcysteine; Adult; Androstadienes; Chromatography, Liquid; Cysteine; Humans; Male; Tandem Mass Spectrometry | 2012 |
Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance.
Topics: Acetylcysteine; Adiposity; Amino Acids; Amino Acids, Sulfur; Animals; Cysteine; Diet; Fatty Acids, Nonesterified; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Lipids; Male; Methionine; Rats; Rats, Inbred F344; Stearoyl-CoA Desaturase; Taurine; Weight Gain | 2013 |
Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Catalase; Cell Line; Cysteine; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Glutathione; Humans; Hydrogen Peroxide; Lung; MAP Kinase Signaling System; Mutation; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Respiratory Mucosa | 2013 |
Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Atherosclerosis; Cell Cycle Proteins; Cysteine; Female; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Free Radical Scavengers; Hematopoietic Stem Cells; Insulin; Macrophages; Male; Mice; Mice, Knockout; Monocytes; Neutrophils; Nitrogen; Oxidative Stress; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine | 2013 |
Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide.
Topics: Acetylcysteine; Acrylamide; Animals; Biomarkers; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Cysteine; DNA Adducts; Epoxy Compounds; Glutathione; Hepatocytes; Inactivation, Metabolic; Male; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
The oxidative stress induced in vivo by Shiga toxin-2 contributes to the pathogenicity of haemolytic uraemic syndrome.
Topics: Acetylcysteine; Animals; Cysteine; Disease Models, Animal; Glutathione; Hemolytic-Uremic Syndrome; Lipid Peroxidation; Male; Malondialdehyde; Mice; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Shiga Toxin 2; Shiga-Toxigenic Escherichia coli | 2013 |
Determination of benzyl isothiocyanate metabolites in human plasma and urine by LC-ESI-MS/MS after ingestion of nasturtium (Tropaeolum majus L.).
Topics: Acetylcysteine; Adult; Biotransformation; Chromatography, Liquid; Cysteine; Dipeptides; Eating; Female; Glutathione; Humans; Isothiocyanates; Male; Middle Aged; Nasturtium; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Flavan-3-ol-cysteine and acetylcysteine conjugates from edible reagents and the stems of Cynomorium songaricum as potent antioxidants.
Topics: Acetylcysteine; Antioxidants; Cynomorium; Cysteine; Flavonoids; Plant Extracts; Plant Stems | 2013 |
Effects of N-acetyl-L-cysteine on target sites of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine; Fullerenes; Glutathione; Hepatocytes; Hydroxylation; Male; Maleates; Malondialdehyde; Membrane Potential, Mitochondrial; Protective Agents; Rats; Rats, Inbred F344; Reactive Oxygen Species; Sulfhydryl Compounds | 2014 |
Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Nucleolus; Cell Proliferation; Cysteine; Cytosol; Drug Resistance, Neoplasm; Flow Cytometry; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Mutation; Nuclear Proteins; Nucleophosmin; Oxides; Pyrazines; Reactive Oxygen Species; Tryptophan; Tumor Cells, Cultured | 2013 |
Rational design, characterization and catalytic application of metal clusters functionalized with hydrophilic, chiral ligands: a proof of principle study.
Topics: Acetylcysteine; Butanones; Catalysis; Cysteine; Glutathione; Hydrogenation; Hydrophobic and Hydrophilic Interactions; Ligands; Metals; Platinum; Stereoisomerism | 2013 |
Phosphorescence detection of L-ascorbic acid with surface-attached N-acetyl-L-cysteine and L-cysteine Mn doped ZnS quantum dots.
Topics: Acetylcysteine; Ascorbic Acid; Cysteine; Humans; Hydrogen-Ion Concentration; Kinetics; Limit of Detection; Luminescent Measurements; Manganese; Molecular Probes; Quantum Dots; Sulfides; Temperature; Zinc Compounds | 2013 |
Development of a potential method based on microchip electrophoresis with fluorescence detection for the sensitive determination of intracellular thiols in RAW264.7 cells.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine; Electrophoresis, Microchip; Fluorescence; Fluorescent Dyes; Glutathione; Heterocyclic Compounds, 3-Ring; Limit of Detection; Macrophages; Maleimides; Mice; Sulfhydryl Compounds | 2014 |
Mobilization of Cd from human serum albumin by small molecular weight thiols.
Topics: Acetylcysteine; Cadmium; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Humans; Protein Binding; Serum Albumin; Sulfhydryl Compounds | 2014 |
Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases.
Topics: Acetylcysteine; Animals; Calmodulin; Cell Line, Tumor; Cell Survival; Cysteine; Down-Regulation; Glutaredoxins; Humans; Mice; Mutagenesis, Site-Directed; Mutation; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Protein Disulfide Reductase (Glutathione); Protein Phosphatase 2; Proteolysis; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
A new BODIPY-based long-wavelength fluorescent probe for chromatographic analysis of low-molecular-weight thiols.
Topics: Acetylcysteine; Animals; Boron Compounds; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cysteine; Dipeptides; Fluorescent Dyes; Glutathione; Homocysteine; Iodoacetamide; Limit of Detection; Male; Mice; Penicillamine; Sulfhydryl Compounds | 2014 |
N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line, Tumor; Cysteine; Deoxycytidine; Gemcitabine; Glutathione; Humans; Male; Mice; Mice, Nude; NF-kappa B; Oxidative Stress; Pancreatic Neoplasms; Signal Transduction; X-Linked Inhibitor of Apoptosis Protein | 2014 |
EAAC1 gene deletion increases neuronal death and blood brain barrier disruption after transient cerebral ischemia in female mice.
Topics: Acetylcysteine; Animals; Blood-Brain Barrier; Cell Death; Cysteine; Disease Models, Animal; Excitatory Amino Acid Transporter 3; Female; Gene Deletion; Glutathione; Ischemic Attack, Transient; Mice; Mice, Knockout; Neurons | 2014 |
Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications.
Topics: Acetylcysteine; Algorithms; Animals; Boron Compounds; Boronic Acids; Captopril; Cattle; Chromatography, High Pressure Liquid; Coumarins; Cysteine; Dithiothreitol; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Models, Chemical; Nitrogen Oxides; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Serum Albumin; Spectrophotometry; Sulfhydryl Compounds | 2014 |
Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.
Topics: Acetylcysteine; Albumins; Apoptosis; Arginine; Aspartate Aminotransferases; Catalysis; Cell Survival; Cysteine; Escherichia coli; Fructose-Bisphosphate Aldolase; Glucose; Glycolates; Glyoxal; Humans; Intracellular Signaling Peptides and Proteins; Lactates; Lysine; Mass Spectrometry; Oncogene Proteins; Oxidative Stress; Parkinsonian Disorders; Protein Deglycase DJ-1; Pyruvaldehyde | 2015 |
Cysteine analogs with a free thiol group promote fertilization by reducing disulfide bonds in the zona pellucida of mice.
Topics: Acetylcysteine; Amino Acids; Animals; Cysteine; Disulfides; Embryo Transfer; Fertilization in Vitro; Glutathione; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Proteins; Spermatozoa; Sulfhydryl Compounds; Zona Pellucida | 2015 |
Strategies for correcting very long chain acyl-CoA dehydrogenase deficiency.
Topics: Acetylcysteine; Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Amino Acid Sequence; Carnitine; Congenital Bone Marrow Failure Syndromes; Cysteine; Dose-Response Relationship, Drug; Fatty Acids; Fibroblasts; Genetic Therapy; Humans; Kinetics; Lipid Metabolism, Inborn Errors; Mitochondrial Diseases; Molecular Sequence Data; Muscular Diseases; Mutation; Oxidation-Reduction; Primary Cell Culture; Skin | 2015 |
Monitoring urinary mercapturic acids as biomarkers of human dietary exposure to acrylamide in combination with acrylamide uptake assessment based on duplicate diets.
Topics: Acetylcysteine; Acrylamide; Adult; Cysteine; Diet; Environmental Exposure; Food Analysis; Food Contamination; Humans; Male | 2016 |
Comparative effects of sulfhydryl compounds on target organellae, nuclei and mitochondria, of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Cell Culture Techniques; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine; DNA Damage; Fullerenes; Hepatocytes; Male; Membrane Potential, Mitochondrial; Methionine; Organelles; Rats, Inbred F344; Reactive Oxygen Species; Sulfhydryl Compounds | 2015 |
N-acetylcysteine stimulates protein synthesis in enterocytes independently of glutathione synthesis.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Cell Proliferation; Cysteine; Enterocytes; Eukaryotic Initiation Factors; Glutathione; Maleates; Protein Biosynthesis; Real-Time Polymerase Chain Reaction; Sus scrofa; TOR Serine-Threonine Kinases | 2016 |
A fluorescent probe for specific detection of cysteine in the lipid dense region of cells.
Topics: Acetylcysteine; Acrylates; Amidohydrolases; Boron Compounds; Colorimetry; Cysteine; Fluorescent Dyes; HCT116 Cells; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Kinetics | 2015 |
Biosynthesis of mercapturic acid derivative of the labdane-type diterpene, cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus: cyslabdan is generated by mycothiol-mediated xenobiotic detoxification.
Topics: Acetylcysteine; Amidohydrolases; Biosynthetic Pathways; Cysteine; Diterpenes; Glycopeptides; Imipenem; Inactivation, Metabolic; Inositol; Methicillin-Resistant Staphylococcus aureus; Multigene Family; Mycelium; Organophosphates; Streptomyces; Xenobiotics | 2016 |
Chromium speciation in human blood samples based on acetyl cysteine by dispersive liquid-liquid biomicroextraction and in-vitro evaluation of acetyl cysteine/cysteine for decreasing of hexavalent chromium concentration.
Topics: Acetylcysteine; Chromium; Cysteine; Drug Evaluation, Preclinical; Environmental Pollutants; Humans; Liquid Phase Microextraction; Prodrugs | 2016 |
The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Tumor; Colorectal Neoplasms; Cysteine; Gene Expression Regulation, Neoplastic; Glutathione; Humans; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proteasome Inhibitors; Rats | 2016 |
Comparison of N-acetylcysteine and cysteine in their ability to replenish intracellular cysteine by a specific fluorescent probe.
Topics: Acetylcysteine; Cell Line; Cysteine; Fluorescent Dyes; Humans; Molecular Structure; Optical Imaging | 2016 |
Simultaneous assessment of endogenous thiol compounds by LC-MS/MS.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Glutathione; Homocysteine; Limit of Detection; Liver; Male; Mice; Reproducibility of Results; Sulfhydryl Compounds; Tandem Mass Spectrometry | 2016 |
Cysteine Supplementation May be Beneficial in a Subgroup of Mitochondrial Translation Deficiencies.
Topics: Acetylcysteine; Carrier Proteins; Cyclooxygenase 2; Cysteine; Dietary Supplements; Fibroblasts; Humans; In Vitro Techniques; MELAS Syndrome; MERRF Syndrome; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; Mutation; Neoplasm Proteins; Oxygen Consumption; Protein Biosynthesis; RNA-Binding Proteins; tRNA Methyltransferases | 2016 |
Parkinsonism-associated protein DJ-1 is a bona fide deglycase.
Topics: Acetylcysteine; Artifacts; Culture Media; Cysteine; Escherichia coli; Glucose; Glycation End Products, Advanced; Glycosylation; Glyoxal; Humans; Intracellular Signaling Peptides and Proteins; Mutation; Oncogene Proteins; Parkinsonian Disorders; Protein Deglycase DJ-1; Pyruvaldehyde | 2017 |
The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells.
Topics: Acetylcysteine; beta-Naphthoflavone; Carbonic Anhydrase Inhibitors; Cell Line; Chromatography, High Pressure Liquid; Cysteine; Cytochrome P-450 Enzyme System; Dexamethasone; Glaucoma; Glucuronides; Humans; Isoniazid; Keratinocytes; Lyases; Methazolamide; Methimazole; Oxidation-Reduction; Oxygenases; Stevens-Johnson Syndrome; Sulfenic Acids; Sulfonic Acids; Tandem Mass Spectrometry | 2017 |
Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome.
Topics: Acetylcysteine; Cysteine; Cysteine Synthase; HeLa Cells; Humans; Isotope Labeling; Metabolome; Oxidation-Reduction; Salmonella typhimurium; Sulfhydryl Compounds; Sulfur; Sulfur Isotopes | 2017 |
Topics: Acetylcysteine; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Cysteine; Dichlorvos; Enzyme Activation; Erythrocytes; Feasibility Studies; Humans; In Vitro Techniques; Insecticides; Iran; Organophosphate Poisoning; Pralidoxime Compounds | 2017 |
Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.
Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred Strains; Signal-To-Noise Ratio; Tissue Distribution; Trichloroethylene | 2018 |
Cysteine-Derived Pleurotin Congeners from the Nematode-Trapping Basidiomycete Hohenbuehelia grisea.
Topics: Acetylcysteine; Agaricales; Animals; Anti-Infective Agents; Basidiomycota; Cysteine; Fungi; Heterocyclic Compounds, 4 or More Rings; Magnetic Resonance Spectroscopy; Nematoda; Sulfhydryl Compounds; Sulfur; Thailand | 2018 |
N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H
Topics: Acetylcysteine; Antioxidants; Cell Line; Cysteine; Humans; Hydrogen Sulfide; Mitochondria; Sulfur; Sulfurtransferases | 2018 |
Response to medical and a novel dietary treatment in newborn screen identified patients with ethylmalonic encephalopathy.
Topics: Acetylcysteine; Amino Acids; Biomarkers; Brain Diseases, Metabolic, Inborn; Cysteine; Diet; Female; Humans; Infant; Infant, Newborn; Lactic Acid; Male; Malonates; Methionine; Metronidazole; Mitochondrial Proteins; Mutation; Neonatal Screening; Nucleocytoplasmic Transport Proteins; Purpura; Sulfur | 2018 |
Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholestyramine Resin; Cysteine; Free Radical Scavengers; Glutathione; Hepatocytes; Homeostasis; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2018 |
S Marks the Spot: Linking the Antioxidant Activity of N-Acetyl Cysteine to H
Topics: Acetylcysteine; Antioxidants; Cysteine; Sulfur | 2018 |
The determination of pharmaceutically active thiols using hydrophilic interaction chromatography followed postcolumn derivatization with o-phthaldialdehyde and fluorescence detection.
Topics: Acetonitriles; Acetylcysteine; Captopril; Chromatography, High Pressure Liquid; Cysteine; Hydrophobic and Hydrophilic Interactions; o-Phthalaldehyde; Propylamines; Spectrometry, Fluorescence; Sulfhydryl Compounds; Temperature | 2018 |
The effects of L-cysteine and N-acetyl-L-cysteine on homocysteine metabolism and haemostatic markers, and on cardiac and aortic histology in subchronically methionine-treated Wistar male rats.
Topics: Acetylcysteine; Animals; Aorta; Biomarkers; Cysteine; Heart; Hemostatics; Homocysteine; Male; Methionine; Rats; Rats, Wistar | 2019 |
Simultaneous determination of total homocysteine, cysteine, glutathione, and N-acetylcysteine in brain homogenates by HPLC.
Topics: Acetylcysteine; Animals; Brain; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Homocysteine; Swine | 2018 |
N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs.
Topics: Acetylcysteine; Cell Proliferation; Culture Media; Cysteine; Endothelial Cells; Ethyl Ethers; Glutathione; Human Umbilical Vein Endothelial Cells; Humans; Pyrrolidonecarboxylic Acid; Thiazolidines | 2018 |
Cysteine Disulfides (Cys-ss-X) as Sensitive Plasma Biomarkers of Oxidative Stress.
Topics: Acetylcysteine; Anemia, Sickle Cell; Antioxidants; Biomarkers; Cysteine; Disulfides; Humans; Oxidative Stress; Sepsis | 2019 |
Label-free gold nanorods sensor array for colorimetric detection and discrimination of biothiols in human urine samples.
Topics: Acetylcysteine; Colorimetry; Cysteamine; Cysteine; Glutathione; Gold; Homocysteine; Humans; Nanotubes; Principal Component Analysis; Sulfhydryl Compounds | 2019 |
Characterization of benzyl isothiocyanate extracted from mashed green papaya by distillation.
Topics: Acetylcysteine; Carica; Cysteine; Distillation; Drug Stability; Drug Storage; Excipients; Freezing; Glutathione; Isothiocyanates; Plant Extracts; Reproducibility of Results | 2019 |
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Edema; Exanthema; Glutathione; Humans; Imines; Male; Protein Binding; Serum Albumin; Skin Diseases; Tandem Mass Spectrometry | 2019 |
Topics: Acetylcysteine; Caco-2 Cells; Chitosan; Curcumin; Cysteine; Drug Carriers; Drug Delivery Systems; Humans; Hydrophobic and Hydrophilic Interactions; Lactoglobulins; Molecular Docking Simulation; Nanoparticles; Particle Size; Peptides | 2019 |
Thiol-water proton exchange of glutathione, cysteine, and N-acetylcysteine: Implications for CEST MRI.
Topics: Acetylcysteine; Cysteine; Glutathione; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Protons; Serum Albumin, Human; Sulfhydryl Compounds; Water | 2020 |
The mercapturic acid pathway.
Topics: Acetylcysteine; Biotransformation; Cysteine; Glutathione; Leukotrienes; Xenobiotics | 2019 |
Effect of Cysteine on Methylglyoxal-Induced Renal Damage in Mesangial Cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line; Cell Survival; Cysteine; Guanidines; Humans; L-Lactate Dehydrogenase; Lactic Acid; Lactoylglutathione Lyase; MAP Kinase Signaling System; Mesangial Cells; Mice; Pyruvaldehyde; Reactive Oxygen Species; Sirtuin 1 | 2020 |
Cysteine becomes conditionally essential during hypobaric hypoxia and regulates adaptive neuro-physiological responses through CBS/H
Topics: Acetylcysteine; Adaptation, Physiological; Adult; Altitude Sickness; Animals; Brain; Cerebrovascular Circulation; Cystathionine beta-Synthase; Cysteine; Disease Models, Animal; Energy Metabolism; Humans; Hydrogen Sulfide; Hypoxia; Male; Oxygen Consumption; Prodrugs; Rats; Young Adult | 2020 |
Stability of
Topics: Acetylcysteine; Amino Acids; Biological Availability; Cysteine; Cystine; Drug Industry; Drug Stability; Drug Storage; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature; Nutritional Requirements; Oxidation-Reduction; Oxygen; Parenteral Nutrition; Parenteral Nutrition Solutions | 2020 |
N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish.
Topics: Acetylcysteine; Animals; Antioxidants; Calcium Channel Blockers; Cardiotoxicity; Cysteine; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Heart Rate; Verapamil; Zebrafish | 2020 |
Are AAMA and GAMA Levels in Urine after Childbirth a Suitable Marker to Assess Exposure to Acrylamide from Passive Smoking during Pregnancy?-A Pilot Study.
Topics: Acetylcysteine; Acrylamide; Biomarkers; Cesarean Section; Chromatography, Liquid; Cysteine; Female; Humans; Infant, Newborn; Maternal Exposure; Parturition; Pilot Projects; Pregnancy; Prenatal Exposure Delayed Effects; Tandem Mass Spectrometry; Tobacco Smoke Pollution | 2020 |
Novel aminoarylcysteine adducts in globin of rats dosed with naphthylamine and nitronaphthalene isomers.
Topics: 1-Naphthylamine; 2-Naphthylamine; Acetylcysteine; Animals; Biomarkers; Cysteine; Globins; Injections, Intraperitoneal; Male; Naphthalenes; Protein Binding; Rats, Wistar | 2021 |
GC-MS approach revealing hidden nitrite reactions in hemolysate using
Topics: Acetylcysteine; Cysteine; Erythrocytes; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Nitrates; Nitrites; Oxygen Isotopes; Sulfhydryl Compounds | 2021 |
Fabrication of a "Selenium Signature" Chemical Probe-Modified Paper Substrate for Simultaneous and Efficient Determination of Biothiols by Paper Spray Mass Spectrometry.
Topics: Acetylcysteine; Biosensing Techniques; Cysteine; Dipeptides; Fluorescent Dyes; Glutathione; Humans; Mass Spectrometry; Paper; Selenium | 2021 |
Superior Properties of N-Acetylcysteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Line; Cysteine; Humans; Male; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Retinal Pigment Epithelium | 2021 |
TRMU deficiency: A broad clinical spectrum responsive to cysteine supplementation.
Topics: Acetylcysteine; Acidosis; Cysteine; DNA, Mitochondrial; Female; Humans; Infant; Leigh Disease; Liver Failure; Liver Transplantation; Male; Mitochondria; Mitochondrial Proteins; Protein Biosynthesis; RNA, Transfer; tRNA Methyltransferases | 2021 |
A Mechanistic-Based and Non-invasive Approach to Quantify the Capability of Kidney to Detoxify Cysteine-Disulfides.
Topics: Acetylcysteine; Animals; Cysteine; Disulfides; Kidney; Kidney Diseases; Mice; Rats | 2021 |
Inhibitory effects of thiol compounds on theaflavin browning and structural analysis of the causative substances.
Topics: Acetylcysteine; Antioxidants; Biflavonoids; Catechin; Cysteine; Glutathione; Oxidation-Reduction; Sulfhydryl Compounds | 2022 |
Glutathione, Cysteine, and D-Penicillamine Role in Exchange of Silver Metal from the Albumin Metal Complex.
Topics: Acetylcysteine; Coordination Complexes; Cysteine; Glutathione; Metals; Penicillamine; Serum Albumin, Bovine; Silver Nitrate; Sulfhydryl Compounds | 2022 |
Identification of a S-(2-succino)cysteine breakdown pathway that uses a novel S-(2-succino) lyase.
Topics: Acetylcysteine; Cysteine; Fumarates; Lyases; Sulfhydryl Compounds | 2022 |
HPLC Study of Product Formed in the Reaction of NBD-Derived Fluorescent Probe with Hydrogen Sulfide, Cysteine,
Topics: Acetylcysteine; Cysteine; Fluorescent Dyes; Glutathione; HeLa Cells; Homocysteine; Humans; Hydrogen Sulfide; Optical Imaging; Sulfhydryl Compounds | 2022 |
N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate toxicity of the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine in human placental villous trophoblast BeWo cells.
Topics: Acetylcysteine; Aminooxyacetic Acid; Cysteine; Cytochrome P-450 CYP3A; Female; Humans; Hydrogen Peroxide; Placenta; Pregnancy; RNA, Messenger; Trichloroethylene; Trophoblasts | 2023 |
Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells.
Topics: Acetylcysteine; Antioxidants; Cysteine; Glycation End Products, Advanced; Maillard Reaction | 2023 |