Compounds > acetylcysteine

acetylcysteine and cysteamine

acetylcysteine has been researched along with cysteamine in 75 studies

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-199038 (50.67)18.7374
1990's8 (10.67)18.2507
2000's8 (10.67)29.6817
2010's12 (16.00)24.3611
2020's9 (12.00)2.80

Authors

AuthorsStudies
Clayette, P; Dormont, D; Fretier, P; Imbach, JL; Mialocq, P; Oiry, J; Puy, JY1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Adriaenssens, P; Ballantyne, A; Park, J; Prescott, LF; Proudfoot, AT1
van Zwieten, PA1
Adam, RD; Critchley, JA; Illingworth, RN; Prescott, LF; Proudfoot, AT; Stewart, MJ1
Prescott, LF; Proudfoot, AT; Stewart, MJ1
Peterson, RG; Rumack, BH1
Prescott, LF2
Austin, F; Carloss, H; Forrester, J; Fuson, T1
Best, L; Krenzelok, EP; Manoguerra, AS1
Gershon, H; Hauck, JB; Parmegiani, R1
Brown, IR; Peterson, TC1
Tang, LD; Tang, ZM1
Lockhart, SP1
Bast, A; Haenen, GR; Timmerman, H; Vermeulen, NP1
Kaplowitz, N; Kuhlenkamp, J; Lu, SC; Robert, A1
Davis, HD; Dominitz, JA; Landauer, MR; Weiss, JF1
Mason, RP; Mottley, C; Toy, K1
Lakin, CA; Oliver, JR; Scott, JS1
Eckert, KG; Issels, RD; Nagele, A; Wilmanns, W1
Davis, M1
Ammon, HP; Enz, G; Hehl, KH; Setiadi-Ranti, A; Verspohl, EJ1
Hayashi, S; Nakai, T1
Butler, JA; Byrne, FD; Patterson, CE; Rhodes, ML1
Boerth, RC; Olson, RD; Stroo, WE2
Jollow, DJ; Keiser, H; Mitchell, JR; Potter, WZ; Thorgeirsson, SS1
Kennedy, JF; Tun, HC1
Hollinger, HZ; Kisil, FT; Sehon, AH1
Bianchi, V; Ghirardo, G; Rovetta, G1
Gilbertson, AA; Smith, JM1
Dunn, JA; Greenberg, RN; Guerrant, RL1
Sedlacek, R; Verhey, LJ1
Critchley, JA; Prescott, LF1
Baker, DG; Constable, WC; Goodchild, NT; Hahn, SS; Kim, JA1
Birkett, DJ; Drew, R; Miners, JO1
Black, M1
Goulding, R; Meredith, TJ1
Pflüger, KH1
Davis, M; Smith, HM; Tredger, JM; Williams, R1
Issels, RD; Meier, T1
Davies, MJ; Puppo, A1
Beyersbergen van Henegouwen, GM; van den Broeke, LT1
de Matos, DG; Furnus, CC; Moses, DF1
Metodiewa, D; Winterbourn, CC1
Bollo, S; Farias, D; Núñez-Vergara, LJ; Squella, JA1
Keisler, D; Lagoo, A; McMurray, RW; Suwannaroj, S1
Halliwell, B; Hua Long, L1
Clayette, P; Dormont, D; Imbach, JL; Mialocq, P; Oiry, J; Puy, JY; Rimaniol, AC1
Hasegawa, K; Inoue, S; Ito, S; Olivares, C; Otake, H; Solano, F; Wakamatsu, K; Yukitake, J1
Casabianca, A; Chiarantini, L; Cinatl, J; Clayette, P; Fraternale, A; Magnani, M; Oiry, J; Orlandi, C; Paoletti, MF; Schiavano, GF; Vogel, JU1
Buondelmonte, C; Cafaro, A; Caputo, A; Castaldello, A; Dominici, S; Ensoli, B; Fraternale, A; Garaci, E; Magnani, M; Palamara, AT; Paoletti, MF; Sgarbanti, R; Tripiciano, A1
Elton, TS; Gupta, NN; Gurney, TO; Haley, BE; Kotha, SR; Magalang, UJ; Malireddy, S; Marsh, CB; Parinandi, NL; Patel, RB; Sauers, LA1
Carloni, E; Casabianca, A; Crinelli, R; Fraternale, A; Magnani, M; Orlandi, C; Palamara, AT; Paoletti, MF; Smietana, M1
Aparecido Volpini, R; Cunha Sanches, TR; de Bragança, AC; Lopes Neri, LA; Macaferri da Fonseca, FA; Moreira Filho, CA; Pache de Faria Guimaraes, L; Seguro, AC; Shimizu, MH; Sumita, NM; Vaisbich, MH1
Baker, EH; Bianconi, S; Caruso, RC; Chandra, G; Griffin, KJ; Gropman, A; Khan, OI; Levin, SW; Liu, A; Miao, N; Mukherjee, AB; Quezado, ZM; Zein, WM; Zhang, Z1
Mole, SE1
Baker, EH; Levin, SW; Mukherjee, AB; Zhang, Z1
Domenech, M; García, E1
Brok, J; Buckley, NA; Chiew, AL; Gluud, C1
Crinelli, R; Fraternale, A; Magnani, M; Retini, M; Smietana, M; Zara, C1
Huang, CZ; Li, CM; Liu, JJ; Wang, J; Yan, HH; Yuan, D1
Chen, W; Deng, HH; He, SB; Huang, KY; Peng, HP; Sun, WM; Xia, XH; Xue, LP; Zha, DJ1
Ambrogini, P; Bartoccini, F; Cesarini, E; Crinelli, R; De Marchis, F; Di Mambro, T; Diotallevi, A; Fraternale, A; Galluzzi, L; Genovese, DA; Green, K; Luchetti, F; Magnani, M; Manuali, E; Pompa, A; Smietana, M; Zara, C1
Amagliani, G; Brandi, G; Fraternale, A; Ligi, D; Magnani, M; Mannello, F; Pierigè, F; Rossi, L; Schiavano, GF; Smietana, M; Zara, C1
Arisaka, A; Ichimoto, K; Kumada, S; Kuwajima, M; Murayama, K; Ogawa, E; Ohtake, A; Osaka, H; Sato-Shirai, I; Watanabe, M1
Domenech, M; González-Camacho, F; Lago, D; Llamosí, M; Pérez-García, C; Román, F; Sempere, J; Yuste, J1
Silva, BR; Silva, JRV1
Anderson, VE; Burg, L; Falk, MJ; Haroon, S; He, J; Kose, M; Mathew, ND; Nair, RM; Nakamaru-Ogiso, E; Osei-Frimpong, B; Seiler, C; Venkata, CRM; Yoon, H1
Chen, Y; Deng, J; Feng, L; Huang, S; Li, F; Liu, D; Luo, J; Ma, K; Ma, S; Tan, C; Wu, D; Zhang, L1
Bartoccini, F; Crinelli, R; Diotallevi, A; Fraternale, A; Galluzzi, L; Magnani, M; Masini, S; Monittola, F; Smietana, M1

Reviews

9 review(s) available for acetylcysteine and cysteamine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Protective agents for acetaminophen overdose.
    Seminars in liver disease, 1986, Volume: 6, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimetidine; Cysteamine; Glucuronates; Glutathione; Humans; Inactivation, Metabolic; Lipid Peroxides; Liver; Methionine; Necrosis; Propylthiouracil

1986
[Therapy of toxic hepatitis].
    Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Adrenal Cortex Hormones; Age Factors; Aged; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Male; Middle Aged; Prognosis; Sex Factors

1985
The treatment of acetaminophen poisoning.
    Annual review of pharmacology and toxicology, 1983, Volume: 23

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Glutathione; Humans; Liver; Methionine; Necrosis; Sulfhydryl Compounds

1983
Acetaminophen hepatotoxicity.
    Gastroenterology, 1980, Volume: 78, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Glutathione; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Methionine

1980
Paracetamol.
    Postgraduate medical journal, 1980, Volume: 56, Issue:657

    Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Cysteamine; Dextropropoxyphene; Humans; Infant; Kidney Diseases; Methionine

1980
Interventions for paracetamol (acetaminophen) overdose.
    The Cochrane database of systematic reviews, 2018, 02-23, Volume: 2

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Cysteamine; Dimercaprol; Drug Overdose; Gastric Lavage; Humans; Intestinal Absorption; Liver Failure, Acute; Liver Transplantation; Methionine; Randomized Controlled Trials as Topic

2018
Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of
    Nutrients, 2019, Jun-07, Volume: 11, Issue:6

    Topics: Acetylcysteine; Animals; Antiviral Agents; Cysteamine; Glutathione; Humans; Immunologic Factors; Prodrugs; Retroviridae; Sulfhydryl Compounds; Virus Diseases

2019
Mechanisms of action of non-enzymatic antioxidants to control oxidative stress during in vitro follicle growth, oocyte maturation, and embryo development.
    Animal reproduction science, 2023, Volume: 249

    Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Carnitine; Cysteamine; Embryonic Development; Glutathione; In Vitro Oocyte Maturation Techniques; Lycopene; Melatonin; Oocytes; Oxidative Stress; Phycocyanin; Quercetin; Reactive Oxygen Species; Resveratrol

2023

Trials

3 trial(s) available for acetylcysteine and cysteamine

ArticleYear
Letter: Cysteamine for paracetamol overdosage.
    Lancet (London, England), 1974, May-18, Volume: 1, Issue:7864

    Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Clinical Trials as Topic; Cysteamine; Dimercaprol; Humans; Penicillamine; Poisoning; Time Factors

1974
N-acetyl-cysteine is associated to renal function improvement in patients with nephropathic cystinosis.
    Pediatric nephrology (Berlin, Germany), 2014, Volume: 29, Issue:6

    Topics: Acetylcysteine; Antioxidants; Child; Cysteamine; Cystine Depleting Agents; Cystinosis; Female; Humans; Kidney Function Tests; Male; Oxidative Stress

2014
Oral cysteamine bitartrate and N-acetylcysteine for patients with infantile neuronal ceroid lipofuscinosis: a pilot study.
    The Lancet. Neurology, 2014, Volume: 13, Issue:8

    Topics: Acetylcysteine; Administration, Oral; Child, Preschool; Cysteamine; Drug Therapy, Combination; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Male; Neuronal Ceroid-Lipofuscinoses; Pilot Projects

2014

Other Studies

63 other study(ies) available for acetylcysteine and cysteamine

ArticleYear
NAC/MEA conjugate: a new potent antioxidant which increases the GSH level in various cell lines.
    Bioorganic & medicinal chemistry letters, 2001, May-07, Volume: 11, Issue:9

    Topics: Acetylcysteine; Antioxidants; Astrocytes; CD4-Positive T-Lymphocytes; Cell Line; Cysteamine; Glutathione; HIV Infections; Humans; Indicators and Reagents; Macrophages; Monocytes; Prodrugs

2001
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.
    Lancet (London, England), 1977, Aug-27, Volume: 2, Issue:8035

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Drug Evaluation; Female; Follow-Up Studies; Humans; Infusions, Parenteral; Male; Methionine; Middle Aged

1977
[Therapy of paracetamol poisoning].
    Nederlands tijdschrift voor geneeskunde, 1979, Feb-24, Volume: 123, Issue:8

    Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Methionine

1979
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
    British medical journal, 1979, Nov-03, Volume: 2, Issue:6198

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Infusions, Parenteral; Kidney Diseases; Liver Diseases; Male; Methionine; Middle Aged; Risk; Time Factors

1979
Paracetamol overdosage.
    British medical journal, 1978, Jan-14, Volume: 1, Issue:6105

    Topics: Acetaminophen; Acetylcysteine; Cysteamine; Humans

1978
Cysteamine or N-acetylcysteine for paracetamol poisoning?
    British medical journal, 1978, Apr-01, Volume: 1, Issue:6116

    Topics: Acetaminophen; Acetylcysteine; Cysteamine; Humans; Time Factors

1978
Toxicity of acetaminophen overdose.
    JACEP, 1978, Volume: 7, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Cysteamine; Humans; Methionine

1978
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage.
    Health bulletin, 1978, Volume: 36, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Liver Diseases; Male; Methionine; Middle Aged; Scotland

1978
Acute acetaminophen intoxication.
    Southern medical journal, 1978, Volume: 71, Issue:8

    Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Liver; Male; Methionine; Suicide, Attempted

1978
Acetaminophen toxity.
    American journal of hospital pharmacy, 1977, Volume: 34, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Necrosis; Sulfhydryl Compounds

1977
Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds.
    Canadian journal of microbiology, 1975, Volume: 21, Issue:3

    Topics: Acetylcysteine; Amino Acids; Antifungal Agents; Aspergillus; Copper; Cysteamine; Cysteine; Drug Antagonism; Glutathione; Organometallic Compounds; Quinolines

1975
Cysteamine in combination with N-acetylcysteine prevents acetaminophen-induced hepatotoxicity.
    Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Interactions; Liver; Male; Mice

1992
[Protective effects of SH-compounds on ischemia reperfusion induced arrhythmias in the isolated rat heart].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1991, Volume: 26, Issue:2

    Topics: Acetylcysteine; Animals; Arrhythmias, Cardiac; Coronary Circulation; Cysteamine; Cysteine; Dihydropyridines; Dimaprit; Female; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Rats; Rats, Inbred Strains; Thiourea

1991
Inhaled thiol and phosphorothiol radioprotectors fail to protect the mouse lung.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1990, Volume: 19, Issue:2

    Topics: Acetylcysteine; Administration, Inhalation; Aerosols; Amifostine; Animals; Cysteamine; Lung; Male; Mice; Mice, Inbred CBA; Radiation Injuries, Experimental

1990
Effect of thiols on lipid peroxidation in rat liver microsomes.
    Chemico-biological interactions, 1989, Volume: 71, Issue:2-3

    Topics: Acetylcysteine; Animals; Cysteamine; Cysteine; Dithiothreitol; Glutathione; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; Penicillamine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds

1989
Role of glutathione status in protection against ethanol-induced gastric lesions.
    Pharmacology, 1989, Volume: 38, Issue:1

    Topics: Acetylcysteine; Animals; Cysteamine; Ethanol; Gastric Mucosa; Glutathione; Male; Maleates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stomach Ulcer; Thiazoles; Thiazolidines

1989
Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine.
    Pharmacology & therapeutics, 1988, Volume: 39, Issue:1-3

    Topics: Acetylcysteine; Amifostine; Animals; Cysteamine; Ditiocarb; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred BALB C; Motor Activity; Radiation-Protective Agents; Sulfhydryl Compounds

1988
Oxidation of thiol drugs and biochemicals by the lactoperoxidase/hydrogen peroxide system.
    Molecular pharmacology, 1987, Volume: 31, Issue:4

    Topics: Acetylcysteine; Captopril; Cysteamine; Cysteine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Hydrogen Peroxide; Lactoperoxidase; Oxygen Consumption; Penicillamine; Peroxidases; Sulfhydryl Compounds

1987
The effect of cysteamine, cystamine, and the structurally related compounds taurine, N-acetyl-cysteine, and D-penicillamine on plasma prolactin levels in normal and estrogen-primed hyperprolactinemic rats.
    Endocrinology, 1987, Volume: 121, Issue:2

    Topics: Acetylcysteine; Animals; Cystamine; Cysteamine; Estradiol; Hyperprolactinemia; Male; Metoclopramide; Penicillamine; Prolactin; Rats; Taurine; Thyrotropin-Releasing Hormone

1987
Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine.
    Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5

    Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cysteamine; Cystine; Female; Glutathione; Glutathione Disulfide; Hydrogen-Ion Concentration; Ovary; Temperature

1988
Cysteine analogues potentiate glucose-induced insulin release in vitro.
    Diabetes, 1986, Volume: 35, Issue:12

    Topics: Acetylcysteine; Animals; Cysteamine; Cysteine; Dose-Response Relationship, Drug; Female; Glucose; Glutathione; Insulin; Insulin Secretion; Islets of Langerhans; Male; Penicillamine; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1986
Oxidant lung injury: intervention with sulfhydryl reagents.
    Lung, 1985, Volume: 163, Issue:1

    Topics: Acetylcysteine; Animals; Cysteamine; Humans; Lung Diseases; Mice; Oxygen; Paraquat; Rats; Rats, Inbred Strains; Sulfhydryl Compounds

1985
Efficacy of sulfhydryl compounds as inhibitors of iron-dependent doxorubicin-enhanced lipid peroxidation.
    Research communications in chemical pathology and pharmacology, 1985, Volume: 48, Issue:2

    Topics: Acetylcysteine; Animals; Cysteamine; Doxorubicin; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Iron; Lipid Peroxides; Microsomes, Liver; Rabbits; Sulfhydryl Compounds

1985
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
    Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Cysteamine; Cytochrome P-450 Enzyme System; Desipramine; Dimercaprol; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Humans; Indicators and Reagents; Liver; Male; Mass Spectrometry; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Sulfhydryl Compounds; Time Factors; Tritium

1974
The reaction of cellulose carbonate with amino and mercapto compounds.
    Carbohydrate research, 1973, Volume: 29, Issue:1

    Topics: Acetylcysteine; Amines; Amino Acids; Aminosalicylic Acids; Carbonates; Cellulose; Chemical Phenomena; Chemistry; Cysteamine; Humans; Serum Albumin; Streptomycin; Sulfhydryl Compounds

1973
In vitro and in vivo inactivation of reagins with mercaptans.
    Clinical allergy, 1971, Volume: 1, Issue:4

    Topics: Acetylcysteine; Animals; Antigen-Antibody Complex; Cysteamine; Cysteine; Desensitization, Immunologic; Haplorhini; Humans; Immunoglobulin E; Macaca; Mercaptoethanol; Passive Cutaneous Anaphylaxis; Penicillamine; Rhinitis, Allergic, Seasonal; Sulfhydryl Compounds

1971
[The action of sulfhydryl substances in fibrosis in joint pathology].
    Minerva medica, 1971, Sep-05, Volume: 62, Issue:66

    Topics: Acetylcysteine; Cysteamine; Dupuytren Contracture; Humans; Joint Diseases; Scleroderma, Systemic; Sulfhydryl Compounds

1971
Management of distalgesic poisoning.
    Lancet (London, England), 1981, Jan-03, Volume: 1, Issue:8210

    Topics: Acetaminophen; Acetylcysteine; Cysteamine; Dextropropoxyphene; Drug Combinations; Humans; Liver

1981
Reduction of the secretory response to Escherichia coli heat-stable enterotoxin by thiol and disulfide compounds.
    Infection and immunity, 1983, Volume: 41, Issue:1

    Topics: Acetylcysteine; Animals; Bacterial Toxins; Body Fluids; Cyclic GMP; Cystamine; Cystathionine; Cysteamine; Cysteine; Cystine; Disulfides; Enterotoxins; Enzyme Activation; Escherichia coli Proteins; Guanylate Cyclase; Intestinal Mucosa; Mice; Rats; Rats, Inbred Strains; Sulfhydryl Compounds

1983
Determination of the radioprotective effects of topical applications of MEA, WR-2721, and N-acetylcysteine on murine skin.
    Radiation research, 1983, Volume: 93, Issue:1

    Topics: Acetylcysteine; Administration, Topical; Amifostine; Animals; Carbon Dioxide; Cysteamine; Dose-Response Relationship, Radiation; Female; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred C3H; Organothiophosphorus Compounds; Oxygen; Radiotherapy; Skin

1983
Topical use of N-acetylcysteine for reduction of skin reaction to radiation therapy.
    Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1

    Topics: Acetylcysteine; Administration, Topical; Animals; Axilla; Buttocks; Cysteamine; Humans; Pilot Projects; Radiation Injuries; Radiation-Protective Agents; Radiotherapy, High-Energy; Skin

1983
Mechanism of action of paracetamol protective agents in mice in vivo.
    Biochemical pharmacology, 1984, Oct-01, Volume: 33, Issue:19

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Buthionine Sulfoximine; Cysteamine; Cysteine; Glutathione; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H

1984
Influence of N-acetylcysteine on the antitumor activity of doxorubicin.
    Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1

    Topics: Acetylcysteine; Animals; Body Weight; Cysteamine; DNA; Doxorubicin; Drug Interactions; Free Radicals; Leukemia P388; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Oxidation-Reduction

1983
[Toxicology and therapy of paracetamol poisoning].
    Der Internist, 1980, Volume: 21, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Cysteamine; Drug Interactions; Ethanol; Gastric Lavage; Glutathione; Half-Life; Methionine; Phenobarbital; Poisoning

1980
Effects of sulphur-containing compounds on paracetamol activation and covalent binding in a mouse hepatic microsomal system.
    Toxicology letters, 1980, Volume: 5, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteamine; In Vitro Techniques; Male; Methionine; Mice; Microsomes, Liver; Mixed Function Oxygenases; Sulfur; Tiopronin

1980
Treatment of severe acetaminophen poisoning with intravenous acetylcysteine.
    Archives of internal medicine, 1981, Feb-23, Volume: 141, Issue:3 Spec No

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Cysteamine; Humans; Injections, Intravenous; Liver; Methionine

1981
Promotion of cyst(e)ine uptake.
    Methods in enzymology, 1995, Volume: 252

    Topics: Acetylcysteine; Animals; Biological Transport; Cell Adhesion; CHO Cells; Cricetinae; Cysteamine; Cysteine; Cystine; Glutathione; Sulfhydryl Compounds

1995
The reactivity of thiol compounds with different redox states of leghaemoglobin: evidence for competing reduction and addition pathways.
    Biochimica et biophysica acta, 1995, Jan-05, Volume: 1246, Issue:1

    Topics: 3-Mercaptopropionic Acid; Acetylcysteine; Cysteamine; Cysteine; Disulfides; Electron Spin Resonance Spectroscopy; Ferric Compounds; Glycine max; Hydrogen Peroxide; Leghemoglobin; Mercaptoethanol; Oxidation-Reduction; Sulfhydryl Compounds; Sulfides; Thioctic Acid

1995
UV-radiation protecting efficacy of thiols, studied with UVA-induced binding of 8-MOP and CPZ to rat epidermal biomacromolecules in vivo.
    International journal of radiation biology, 1993, Volume: 63, Issue:4

    Topics: Acetylcysteine; Animals; Captopril; Chlorpromazine; Cysteamine; Epidermis; Ergothioneine; Female; Mesna; Methoxsalen; Penicillamine; Radiation-Protective Agents; Rats; Rats, Wistar; Sulfhydryl Compounds; Tiopronin; Ultraviolet Rays

1993
Glutathione synthesis during in vitro maturation of bovine oocytes: role of cumulus cells.
    Biology of reproduction, 1997, Volume: 57, Issue:6

    Topics: Acetylcysteine; Animals; Cattle; Cells, Cultured; Coculture Techniques; Cysteamine; Cysteine; Cystine; Female; Glutathione; Oocytes; Ovarian Follicle

1997
Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide.
    Free radical biology & medicine, 1999, Volume: 27, Issue:3-4

    Topics: Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cysteamine; Cysteine; Dithiothreitol; Glutathione; Hydrogen Peroxide; Oxygen Consumption; Penicillamine; Reactive Oxygen Species; Sulfhydryl Compounds; Superoxides; Xanthine Oxidase

1999
An electrochemical evidence of free radicals formation from flutamide and its reactivity with endo/xenobiotics of pharmacological relevance.
    Bioelectrochemistry (Amsterdam, Netherlands), 2001, Volume: 53, Issue:1

    Topics: Acetylcysteine; Adenine; Androgen Antagonists; Cysteamine; Electrochemistry; Flutamide; Free Radical Scavengers; Free Radicals; Glutathione; Kinetics; Thermodynamics; Thymine; Uracil; Xenobiotics

2001
Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE).
    Lupus, 2001, Volume: 10, Issue:4

    Topics: Acetylcysteine; Adjuvants, Immunologic; Animals; Antioxidants; Cysteamine; Female; Free Radical Scavengers; Humans; Lupus Erythematosus, Systemic; Mice; Radiation-Protective Agents; T-Lymphocytes

2001
Oxidation and generation of hydrogen peroxide by thiol compounds in commonly used cell culture media.
    Biochemical and biophysical research communications, 2001, Sep-07, Volume: 286, Issue:5

    Topics: Acetylcysteine; Animals; Cattle; Cell Culture Techniques; Culture Media; Cysteamine; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Electrophysiology; Free Radical Scavengers; Glutathione; Homocysteine; Hydrogen Peroxide; Oxidation-Reduction; Sulfhydryl Compounds

2001
[Oxidative metabolism of HIV-infected macrophages: the role of glutathione and a pharmacologic approach].
    Pathologie-biologie, 2001, Volume: 49, Issue:7

    Topics: Acetylcysteine; Anti-HIV Agents; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Cysteamine; Drug Evaluation, Preclinical; Glutathione; HIV-1; Humans; Macrophages; Oxidative Stress; Prodrugs; Tumor Necrosis Factor-alpha; Virus Replication

2001
Synthesis and selective in vitro anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol.
    Melanoma research, 2003, Volume: 13, Issue:6

    Topics: 3T3 Cells; Acetylcysteine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cysteamine; Glutathione; Inhibitory Concentration 50; Kinetics; Magnetic Resonance Spectroscopy; Melanoma; Melanoma, Experimental; Mice; Models, Chemical; Monophenol Monooxygenase; Phenols; Stereoisomerism; Time Factors; Tyrosine

2003
Inhibition of murine AIDS by pro-glutathione (GSH) molecules.
    Antiviral research, 2008, Volume: 77, Issue:2

    Topics: Acetylcysteine; Animals; Anti-HIV Agents; Cell Proliferation; Cysteamine; Disease Models, Animal; DNA, Viral; Female; Glutathione; Hypergammaglobulinemia; Immunoglobulin G; Leukemia Virus, Murine; Lymph Nodes; Lymphocytes; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Organ Size; Polymerase Chain Reaction; Prodrugs; Spleen

2008
Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules.
    Vaccine, 2011, Sep-16, Volume: 29, Issue:40

    Topics: Acetylcysteine; Adjuvants, Immunologic; AIDS Vaccines; Animals; Cysteamine; Epitope Mapping; Female; Glutathione; HIV Antibodies; HIV Infections; HIV-1; Immunity, Cellular; Immunoglobulin G; Immunoglobulin Isotypes; Immunologic Factors; Interferon-gamma; Interleukin-12; Interleukin-2; Mice; Mice, Inbred BALB C; Prodrugs; tat Gene Products, Human Immunodeficiency Virus; Th1 Cells; Th2 Cells

2011
Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercap
    Toxicology mechanisms and methods, 2012, Volume: 22, Issue:5

    Topics: Acetylcysteine; Actin Cytoskeleton; Animals; Antioxidants; Bleomycin; Cattle; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cysteamine; Endothelial Cells; Endothelium, Vascular; Glutathione; Idiopathic Pulmonary Fibrosis; Lung; Microscopy, Fluorescence; Molecular Structure; Oxidation-Reduction; Phthalic Acids; Reactive Oxygen Species; Structure-Activity Relationship; Sulfhydryl Compounds

2012
Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Acetylcysteine; Animals; Cell Line; Cysteamine; Enzyme Activation; Female; Glutathione; Interferon Regulatory Factor-1; Interleukin-12 Subunit p40; Interleukin-27; Macrophages; Mice; NF-kappa B; Phosphorylation; Signal Transduction; STAT1 Transcription Factor; Sulfhydryl Compounds

2013
Development of new treatments for Batten disease.
    The Lancet. Neurology, 2014, Volume: 13, Issue:8

    Topics: Acetylcysteine; Cysteamine; Female; Humans; Male; Neuronal Ceroid-Lipofuscinoses

2014
MRI Brain Volume Measurements in Infantile Neuronal Ceroid Lipofuscinosis.
    AJNR. American journal of neuroradiology, 2017, Volume: 38, Issue:2

    Topics: Acetylcysteine; Aging; Brain; Brain Stem; Cerebellum; Cerebrum; Child; Child, Preschool; Cysteamine; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Magnetic Resonance Imaging; Male; Neuronal Ceroid-Lipofuscinoses; Thalamus

2017
N-Acetyl-l-Cysteine and Cysteamine as New Strategies against Mixed Biofilms of Nonencapsulated Streptococcus pneumoniae and Nontypeable Haemophilus influenzae.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:2

    Topics: Acetylcysteine; Antibodies; Antioxidants; Biofilms; Cysteamine; Haemophilus influenzae; Microscopy, Confocal; Streptococcus pneumoniae

2017
Label-free gold nanorods sensor array for colorimetric detection and discrimination of biothiols in human urine samples.
    Talanta, 2019, Oct-01, Volume: 203

    Topics: Acetylcysteine; Colorimetry; Cysteamine; Cysteine; Glutathione; Gold; Homocysteine; Humans; Nanotubes; Principal Component Analysis; Sulfhydryl Compounds

2019
Rational Design of High-Performance Donor-Linker-Acceptor Hybrids Using a Schiff Base for Enabling Photoinduced Electron Transfer.
    Analytical chemistry, 2020, 01-21, Volume: 92, Issue:2

    Topics: Acetylcysteine; Cysteamine; Density Functional Theory; Electron Transport; Gold; Metal Nanoparticles; Particle Size; Photochemical Processes; Pyridoxal Phosphate; Schiff Bases; Surface Properties

2020
I-152, a supplier of N-acetyl-cysteine and cysteamine, inhibits immunoglobulin secretion and plasma cell maturation in LP-BM5 murine leukemia retrovirus-infected mice by affecting the unfolded protein response.
    Biochimica et biophysica acta. Molecular basis of disease, 2020, 12-01, Volume: 1866, Issue:12

    Topics: Acetylcysteine; Animals; Antiviral Agents; Cysteamine; Disease Models, Animal; Female; Immunoglobulins; Injections, Intraperitoneal; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Plasma Cells; Protein Unfolding; Retroviridae Infections; Tumor Virus Infections; Unfolded Protein Response

2020
Redox homeostasis as a target for new antimycobacterial agents.
    International journal of antimicrobial agents, 2020, Volume: 56, Issue:4

    Topics: Acetylcysteine; Anti-Bacterial Agents; Cysteamine; Cytokines; Glutathione; Humans; Macrophages; Microbial Sensitivity Tests; Mycobacterium avium; Oxidation-Reduction; Oxidative Stress

2020
Valine-restricted diet for patients with ECHS1 deficiency: Divergent clinical outcomes in two Japanese siblings.
    Brain & development, 2021, Volume: 43, Issue:2

    Topics: Acetylcysteine; Cysteamine; Diet Therapy; Enoyl-CoA Hydratase; Family; Female; Genetic Testing; Humans; Infant; Japan; Leigh Disease; Magnetic Resonance Imaging; Male; Mutation; Pedigree; Siblings; Treatment Outcome; Valine

2021
Clearance of mixed biofilms of Streptococcus pneumoniae and methicillin-susceptible/resistant Staphylococcus aureus by antioxidants N-acetyl-L-cysteine and cysteamine.
    Scientific reports, 2022, 04-23, Volume: 12, Issue:1

    Topics: Acetylcysteine; Anti-Bacterial Agents; Antioxidants; Biofilms; Cysteamine; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus pneumoniae

2022
N-acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome.
    Human molecular genetics, 2023, 06-05, Volume: 32, Issue:12

    Topics: Acetylcysteine; Adult; Animals; Azides; Brain Death; Cysteamine; Cytochrome-c Oxidase Deficiency; Electron Transport Complex IV; Glutathione; Humans; Lactates; Leigh Disease; Membrane Proteins; Mitochondrial Proteins; Zebrafish

2023
Cysteamine and
    Journal of agricultural and food chemistry, 2023, May-10, Volume: 71, Issue:18

    Topics: Acetylcysteine; Animals; Antioxidants; Cysteamine; Female; Oxidative Stress; Placenta; Pregnancy; Swine

2023
A synthetic thiol molecule releasing N-acetyl-l-cysteine and cysteamine drives early up-regulation of immunoproteasome subunits in the lymph nodes of mice infected with LP-BM5 leukemia retrovirus.
    Biochimica et biophysica acta. Molecular basis of disease, 2024, Volume: 1870, Issue:1

    Topics: Acetylcysteine; Animals; Cysteamine; Leukemia; Lymph Nodes; Mice; Murine Acquired Immunodeficiency Syndrome; Retroviridae; Sulfhydryl Compounds; Up-Regulation

2024