acetylcysteine and cyclosporine

acetylcysteine has been researched along with cyclosporine in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (5.97)	18.2507
2000's	33 (49.25)	29.6817
2010's	25 (37.31)	24.3611
2020's	5 (7.46)	2.80

Authors

Authors	Studies
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
D'Acunto, CW; Gonzalez, G; Hodoň, J; Kaňovský, P; Kazakova, A; Strnad, M; Urban, M	1
Benet, LZ; Berg-Candolfi, M; Candolfi, E	1
Blázquez, MV; Macho, A; Muñoz, E; Navas, P	1
Al Khader, A; Al Sulaiman, M; Morais, C; Sobki, S; Tariq, M	1
Darnell, BF; Grammer, AC; Heaney, J; Lipsky, PE; McFarland, RD	1
Ong, CN; Shen, HM; Yang, CF	1
Ding, WX; Liu, J; Ong, CN; Shen, HM; Yang, CF	1
Dawson, TM; Engelender, S; Igarashi, S; L Dawson, V; Rao, RK; Ross, CA; Sawa, A; Tanaka, Y; Tanzi, RE; Wanner, T	1
DePierre, JW; Grandér, D; Panaretakis, T; Shabalina, IG; Shoshan, MC	1
Morley, SJ; Pain, VM	1
Castranova, V; Costa, M; Huang, C; Ju, G; Leonard, SS; Li, J; Shi, X; Vallyathan, V; Zhang, Z	1
Gil, DP; Patiño, P; Rojas, M; Rugeles, MT	1
Agapito, MT; Benavides, A; Ceña, V; Galindo, MF; González, C; González-García, C; Jordán, J; Tornero, D	1
Lum, MG; Nagley, P	1
Chang, CH; Chang, GD; Che, D; Chen, ZJ; Liu, S; Vetter, M	1
Bauer, TM; Daniel, V; Naujokat, C; Opelz, G; Sadeghi, M	1
Fujita, H; Inoue, A; Kanno, T; Muranaka, S; Tamai, H; Utsumi, K	1
Gabryel, B; Małecki, A; Toborek, T	1
Chakrabarti, SK; Lemieux, N; M'Bemba-Meka, P	1
de Assunção Silva, F; Di Marco, GS; Di Tommaso, AB; Glória, MA; Gori Mouro, M; Higa, EM; Lessio, C; Schor, N	1
Guo, YL; Lu, S; Ma, X; Wu, XQ; Zhang, X	1
Alvarez-Barrientos, A; Fernández, AP; Lamas, S; León-Gómez, E; Navarro-Antolín, J; Redondo-Horcajo, M; Rodrigo, J; Zaragoza, C	1
Andreeff, M; Bernstein, SH; Brookes, PS; Hilchey, S; Konopleva, M; Morse, K; Phipps, R; Ray, D; Salim, S; Tompkins, A; Young, SM	1
Carrero, JC; Montfort, I; Nequiz, M; Olivos-García, A; Pérez-Tamayo, R; Ramos, E; Tello, E	1
Durgut, R; Duru, M; Kaya, H; Koc, A; Sogut, S; Uz, E; Yilmaz, HR	1
Armstrong, JS; Lu, C	1
Barhanin, J; Belfodil, R; Duranton, C; é Barriere, H; L'Hoste, S; Poet, M; Poujeol, C; Poujeol, P; Rubera, I; Tauc, M	1
Burke, AS; Hinson, JA; James, LP; Kurten, RC; Redeker, K	1
Hallak, M; Levy, I; Mazar, J; Nathan, I; Shpilberg, O; Vazana, L	1
Kaminskyy, V; Kulachkovskyy, O; Stoika, R	1
Duan, S; Ge, J; He, Y; Jiang, RZ; Leung, KW; Peng, Z; Tombran-Tink, J; Zhang, YH; Zhong, XF	1
Hayashi, H; Katoh, H; Kawashima, H; Odagiri, K; Saotome, M; Satoh, H; Takeuchi, Y; Tominaga, H; Urushida, T	1
Akaydin, Y; Duru, M; Helvaci, MR; Koç, A; Kuvandik, G; Nacar, A; Oksüz, H; Söğüt, S; Yönden, Z	1
Chang, LS; Chen, KC; Lin, SR	1
Hazra, B; Kumar, A; Kumar, B; Mishra, KP; Pandey, BN	1
Abdallah, Y; Erdogan, A; Gündüz, D; Iraqi, W; Kasseckert, SA; Ladilov, Y; Neuhof, C; Piper, HM; Reusch, HP; Said, M; Schlüter, KD; Shahzad, T; Tillmanns, H	1
Bass, D; Mojtahed, A; Yeh, AM	1
Chen, CY; Chen, KT; Chen, TL; Chuang, YH; Chung, JG; Hour, MJ; Kuo, SC; Lu, CC; Yang, JS	1
Essig, M; Gastinel, LN; Lamoureux, F; Marquet, P; Mestre, E; Sauvage, FL	1
Bauersachs, J; Becker, BF; Brielmeier, M; Conrad, M; David, R; Franz, WM; Hinkel, R; Horstkotte, J; Jeremias, I; Kiermayer, C; Kupatt, C; Lange, P; Mandal, PK; Naebauer, M; Perisic, T; Schmitt, S; Schneider, M; Schroeder, M; Schulz, S; Sinowatz, F; Widder, J; Ziegler, T; Zischka, H	1
Chen, CH; Lin, ML; Ong, PL; Yang, JT	1
Chung, BH; Doh, KC; Hyoung, BJ; Lim, SW; Piao, SG; Yang, CW	1
Fernando, SL	1
Chen, J; Du, M; Fu, D; Hammad, SM; Lyons, TJ; Wilson, K; Wu, M; Yang, S; Zhang, J	1
Chang, YC; Huang, FM; Kuan, YH; Lee, SS; Tsai, CH	1
Castelain, F; Humbert, P	1
Gross, N	1
Chung, BH; Doh, KC; Heo, SB; Jin, L; Kang, SH; Li, C; Lim, SW; Piao, SG; Yang, CW	1
Abe, N; Aritomi, K; Irie, T; Irikura, M; Ishitsuka, Y; Kai, H; Shimizu, D; Shuto, T; Tomishima, Y	1
Petrov, AM; Yakovleva, AA; Zefirov, AL	1
Aleksiejuk, P; Banki, K; Bonilla, E; Francis, L; Landas, SK; Liu, Y; Marchena-Mendez, I; Oaks, Z; Patel, J; Perl, A; Yu, J	1
Coppo, P; Froissart, A	1
Ahmadian, E; Babaei, H; Eftekhari, A; Eghbal, MA; Mohajjel Nayebi, A	1
Kinoshita, Y; Saeki, H	1
Chen, Z; Qin, X	1
Chen, Y; Huang, S; Jin, X; Ma, J; Pan, Y; Ren, X; Sun, X; Wismeijer, D; Wu, G; Yu, Q; Zhang, C; Zhang, X; Zheng, B	1
Enver Ozan, İ; Erdem Güzel, E; Gül, M; Kavak Balgetir, M; Kaya Tektemur, N; Ozan Kocamüftüoğlu, G; Özcan Yıldırım, S; Tektemur, A; Yalçın, T	1
Beecker, J; Jacobsen, A; Langley, A; Mutter, E; Olabi, B; Pardo Pardo, J; Parker, R; Ramsay, T; Saavedra, A; Shelley, A; Stewart, F; Worley, B	1
Galstyan, GM; Kalinina, II; Klebanova, EE; Maschan, AA	1

Reviews

6 review(s) available for acetylcysteine and cyclosporine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The management of toxic epidermal necrolysis. The Australasian journal of dermatology, 2012, Volume: 53, Issue:3 Topics: Acetylcysteine; Adrenal Cortex Hormones; Burn Units; Cyclosporine; Enzyme Inhibitors; Free Radical Scavengers; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Pharmacogenetics; Plasmapheresis; Stevens-Johnson Syndrome; Tumor Necrosis Factor Inhibitors	2012
Toxic epidermal necrolysis. Current drug safety, 2012, Nov-01, Volume: 7, Issue:5 Topics: Acetylcysteine; Adrenal Cortex Hormones; Cyclosporine; Humans; Plasmapheresis; Prognosis; Stevens-Johnson Syndrome; Tumor Necrosis Factor-alpha	2012
Treatment of thrombotic thrombocytopenic purpura beyond therapeutic plasma exchange. Hematology. American Society of Hematology. Education Program, 2015, Volume: 2015 Topics: Acetylcysteine; ADAM Proteins; ADAMTS13 Protein; Bortezomib; Clinical Trials as Topic; Cyclophosphamide; Cyclosporine; Humans; Plasma Exchange; Platelet Aggregation Inhibitors; Prognosis; Purpura, Thrombotic Thrombocytopenic; Recombinant Proteins; Recurrence; Risk; Rituximab; Splenectomy; Steroids; Treatment Outcome; Vincristine; von Willebrand Factor	2015
A Review of the Active Treatments for Toxic Epidermal Necrolysis. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2017, Volume: 84, Issue:3 Topics: Acetylcysteine; Cyclosporine; Etanercept; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Infliximab; Plasmapheresis; Stevens-Johnson Syndrome; Thalidomide; Tumor Necrosis Factor-alpha	2017
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome. The Cochrane database of systematic reviews, 2022, 03-11, Volume: 3 Topics: Acetylcysteine; Adrenal Cortex Hormones; Adult; Autoimmune Diseases; Child; Cyclosporine; Etanercept; Female; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Observational Studies as Topic; Stevens-Johnson Syndrome; Thalidomide; Tumor Necrosis Factor-alpha	2022

Other Studies

61 other study(ies) available for acetylcysteine and cyclosporine

Article	Year
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models. European journal of medicinal chemistry, 2021, Mar-05, Volume: 213 Topics: Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Isoquinolines; Membrane Potential, Mitochondrial; Models, Biological; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Structure-Activity Relationship; Triazoles; Triterpenes	2021
Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:4 Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Arginine; Aryl Hydrocarbon Hydroxylases; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Interferon-gamma; Intestinal Mucosa; Jejunum; Macrophages, Peritoneal; Male; Mice; Mice, Inbred CBA; Microsomes; Microsomes, Liver; Nitrites; Oxidoreductases, N-Demethylating; Toxoplasmosis, Animal	1996
Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1998, Volume: 9, Issue:3 Topics: Acetylcysteine; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Cyclosporine; Diterpenes; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinases; NADH, NADPH Oxidoreductases; NFATC Transcription Factors; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Suppressor Protein p53	1998
N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:4 Topics: Acetylcysteine; Animals; Cyclosporine; Drug Antagonism; Free Radical Scavengers; Immunosuppressive Agents; Kidney; Male; Organ Transplantation; Oxidative Stress; Rats; Rats, Sprague-Dawley	1999
Expression, regulation, and function of B cell-expressed CD154 in germinal centers. Journal of immunology (Baltimore, Md. : 1950), 1999, Oct-15, Volume: 163, Issue:8 Topics: Acetylcysteine; B-Lymphocyte Subsets; CD40 Antigens; CD40 Ligand; Cell Communication; Cell Count; Cell Separation; Cells, Cultured; Cyclosporine; Flavonoids; Germinal Center; Humans; Immunologic Memory; Immunophenotyping; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Palatine Tonsil; Protein Synthesis Inhibitors; Receptors, Antigen, B-Cell; Up-Regulation	1999
Intracellular thiol depletion causes mitochondrial permeability transition in ebselen-induced apoptosis. Archives of biochemistry and biophysics, 2000, Aug-15, Volume: 380, Issue:2 Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Azoles; Buthionine Sulfoximine; Calcium; Caspase 3; Caspase 9; Caspases; Cyclosporine; Cytochrome c Group; Egtazic Acid; Humans; Isoindoles; Membrane Potentials; Mitochondria, Liver; Organoselenium Compounds; Permeability; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Tumor Cells, Cultured	2000
Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG(2) cells: mitochondria serve as the main target. Free radical biology & medicine, 2001, Jan-01, Volume: 30, Issue:1 Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase Inhibitors; Caspases; Cyclic N-Oxides; Cyclosporine; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutathione; Humans; In Situ Nick-End Labeling; Kinetics; Liver Neoplasms; Membrane Potentials; Mitochondria; Signal Transduction; Sodium Selenite; Spin Labels; Superoxides; Trifluoperazine; Tumor Cells, Cultured	2001
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Human molecular genetics, 2001, Apr-15, Volume: 10, Issue:9 Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Immunoenzyme Techniques; Membrane Potentials; Mitochondria; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Synucleins; Tetracycline; Transfection	2001
Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid. Toxicology and applied pharmacology, 2001, May-15, Volume: 173, Issue:1 Topics: Acetylcysteine; Apoptosis; Caprylates; Carcinogens; Carcinoma, Hepatocellular; Caspase 9; Caspases; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Fluorocarbons; Humans; Hydrogen Peroxide; Kinetics; Liver Neoplasms; Membrane Potentials; Mitochondria, Liver; Reactive Oxygen Species; Superoxides; Tumor Cells, Cultured	2001
Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines. FEBS letters, 2001, Aug-17, Volume: 503, Issue:2-3 Topics: Acetylcysteine; Apoptosis; Calpain; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Eukaryotic Initiation Factor-4G; fas Receptor; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Jurkat Cells; Leupeptins; Multienzyme Complexes; Peptide Fragments; Peptide Initiation Factors; Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine; T-Lymphocytes	2001
Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer research, 2001, Nov-15, Volume: 61, Issue:22 Topics: Acetylcysteine; Animals; Calcineurin; Calcium; Carcinogens; Cells, Cultured; Chelating Agents; Cyclosporine; Deferoxamine; DNA-Binding Proteins; Drug Synergism; Fibroblasts; Free Radical Scavengers; Hydrogen Peroxide; Mice; NFATC Transcription Factors; Nickel; Nuclear Proteins; Reactive Oxygen Species; Thapsigargin; Transcription Factors; Transcriptional Activation; Transfection	2001
Differential modulation of apoptosis and necrosis by antioxidants in immunosuppressed human lymphocytes. Toxicology and applied pharmacology, 2002, Apr-15, Volume: 180, Issue:2 Topics: Acetylcysteine; Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antioxidants; Apoptosis; Ascorbic Acid; Cyclosporine; Dexamethasone; Glucocorticoids; Humans; Immunosuppressive Agents; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Lectins, C-Type; Lymphocyte Activation; Lymphocytes; Male; Necrosis; Phytohemagglutinins; Superoxides	2002
Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cells. British journal of pharmacology, 2002, Volume: 137, Issue:7 Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Caspases; Catalase; Cattle; Cell Survival; Chromaffin Cells; Cyclosporine; Cytochrome c Group; Enzyme Activation; Glutathione; Metalloporphyrins; Mitochondria; Permeability; Superoxides; Veratridine; Vitamin E	2002
Two phases of signalling between mitochondria during apoptosis leading to early depolarisation and delayed cytochrome c release. Journal of cell science, 2003, Apr-15, Volume: 116, Issue:Pt 8 Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Calcium Signaling; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Caspases; Cell Line, Tumor; Cyclosporine; Cytochromes c; Egtazic Acid; Green Fluorescent Proteins; Humans; Luminescent Proteins; Microscopy, Confocal; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Signal Transduction; Time Factors	2003
Cyclosporin A disrupts bradykinin signaling through superoxide. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:5 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Animals; Antioxidants; Blotting, Western; Bradykinin; Cyclic GMP; Cyclosporine; Enzyme Activation; Free Radical Scavengers; GTP-Binding Proteins; Guanylate Cyclase; LLC-PK1 Cells; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Onium Compounds; Phospholipases; Quercetin; Receptor, Bradykinin B2; Receptors, Bradykinin; Signal Transduction; Solubility; Superoxides; Swine; Tyrosine; Vitamin K 3	2003
Cell cycle- and activation-dependent regulation of cyclosporin A-induced T cell apoptosis. Biochemical and biophysical research communications, 2003, Oct-17, Volume: 310, Issue:2 Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Immunosuppressive Agents; Jurkat Cells; Lymphocyte Activation; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes	2003
Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. Free radical biology & medicine, 2004, Oct-15, Volume: 37, Issue:8 Topics: 2-Methoxyestradiol; Acetylcysteine; Amino Acid Chloromethyl Ketones; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Chromones; Cyclic AMP; Cyclosporine; Cysteine Proteinase Inhibitors; Cytochromes c; Diclofenac; DNA Fragmentation; DNA, Neoplasm; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Estradiol; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase	2004
Immunosuppressive immunophilin ligands attenuate damage in cultured rat astrocytes depleted of glutathione and exposed to simulated ischemia in vitro. Comparison with N-acetylcysteine. Neurotoxicology, 2005, Volume: 26, Issue:3 Topics: Acetylcysteine; Animals; Apoptosis; Astrocytes; Benzimidazoles; Brain Ischemia; Cell Separation; Cells, Cultured; Cyclosporine; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Immunophilins; Immunosuppressive Agents; Ligands; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Tacrolimus; Tetrazolium Salts; Thiazoles	2005
Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulfate-induced human lymphocyte death in vitro. Chemico-biological interactions, 2005, Sep-10, Volume: 156, Issue:1 Topics: Acetylcysteine; Calcium; Catalase; Cell Death; Cyclosporine; Deferoxamine; Glutathione; Homeostasis; Humans; Hydrogen Peroxide; Lymphocytes; Mannitol; Membrane Potentials; Mitochondria; Nickel; Oxidative Stress; Thiourea	2005
Cyclosporine A and NAC on the inducible nitric oxide synthase expression and nitric oxide synthesis in rat renal artery cultured cells. Kidney international, 2005, Volume: 68, Issue:6 Topics: Acetylcysteine; Animals; Cell Survival; Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Immunosuppressive Agents; Luminescence; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Renal Artery; RNA, Messenger	2005
Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles. Cell research, 2006, Volume: 16, Issue:10 Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium; Chromosomes, Mammalian; Cyclosporine; Female; Hydrogen Peroxide; Membrane Potentials; Metaphase; Mice; Mitochondria; Mitochondrial Membranes; Oocytes; Oxidative Stress; Radiography; Spindle Apparatus	2006
Role of peroxynitrite in endothelial damage mediated by Cyclosporine A. Free radical biology & medicine, 2007, Feb-01, Volume: 42, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Cattle; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Endothelial Cells; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine	2007
The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore. Cancer research, 2007, Feb-15, Volume: 67, Issue:4 Topics: Acetylcysteine; Animals; Apoptosis; B-Lymphocytes; Burkitt Lymphoma; Cyclosporine; Humans; Lymphoma, B-Cell; Male; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2007
Late experimental amebic liver abscess in hamster is inhibited by cyclosporine and N-acetylcysteine. Experimental and molecular pathology, 2007, Volume: 82, Issue:3 Topics: Acetylcysteine; Animals; Antiviral Agents; Cricetinae; Cyclosporine; Entamoeba histolytica; Immunosuppression Therapy; Immunosuppressive Agents; Liver Abscess, Amebic; Sirolimus; Tacrolimus	2007
The protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in rats. Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione Peroxidase; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Wistar; Superoxide Dismutase	2008
Role of calcium and cyclophilin D in the regulation of mitochondrial permeabilization induced by glutathione depletion. Biochemical and biophysical research communications, 2007, Nov-23, Volume: 363, Issue:3 Topics: Acetylcysteine; Blotting, Western; Calcium; Cell Line, Tumor; Cell Survival; Chelating Agents; Cyclophilins; Cyclosporine; Cytosol; Egtazic Acid; Flow Cytometry; Free Radical Scavengers; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Organophosphorus Compounds; Peptidyl-Prolyl Isomerase F; Permeability; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Ubiquinone	2007
Role of TASK2 in the control of apoptotic volume decrease in proximal kidney cells. The Journal of biological chemistry, 2007, Dec-14, Volume: 282, Issue:50 Topics: Acetylcysteine; Animals; Apoptosis; Calcium; Caspase 3; Cell Line, Transformed; Cell Size; Cyclosporine; Enzyme Inhibitors; Free Radical Scavengers; Kidney Tubules, Proximal; Mice; Mice, Knockout; Peptides; Potassium; Potassium Channels, Tandem Pore Domain; Reactive Oxygen Species; Staurosporine; Tumor Necrosis Factor-alpha	2007
Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. Journal of toxicology and environmental health. Part A, 2007, Volume: 70, Issue:22 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Cells, Cultured; Chloroform; Cyclosporine; Female; Glutathione; Hepatocytes; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mitochondria, Liver; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine	2007
A molecular mechanism for mimosine-induced apoptosis involving oxidative stress and mitochondrial activation. Apoptosis : an international journal on programmed cell death, 2008, Volume: 13, Issue:1 Topics: Acetylcysteine; Animals; Apoptosis; Caspases; Cell Line, Tumor; Cyclosporine; Cytochromes c; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mimosine; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Stress; Rats; Reactive Oxygen Species	2008
A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids. Toxicology letters, 2008, Apr-01, Volume: 177, Issue:3 Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Benzophenanthridines; Cells, Cultured; Chelidonium; Cyclosporine; DNA Damage; Dose-Response Relationship, Drug; Humans; Isoquinolines; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species	2008
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:4 Topics: Acetylcysteine; Adenosine Triphosphate; Adolescent; Adult; Annexin A5; Antioxidants; Apoptosis; Cells, Cultured; Cyclosporine; Cytochromes c; Electron Transport Complex I; Glaucoma, Open-Angle; Humans; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Middle Aged; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Reactive Oxygen Species; Rotenone; Trabecular Meshwork; Uncoupling Agents; Vitamin E	2008
Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:1 Topics: Acetylcysteine; Animals; Antioxidants; Cyclosporine; Heart Ventricles; Male; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Palmitoyl Coenzyme A; Palmitoylcarnitine; Permeability; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors	2008
Protective effects of N-acetylcysteine on cyclosporine-A-induced nephrotoxicity. Renal failure, 2008, Volume: 30, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Analysis of Variance; Animals; Biopsy, Needle; Blood Urea Nitrogen; Creatinine; Cyclosporine; Disease Models, Animal; Immunohistochemistry; Kidney; Male; Malondialdehyde; Microscopy; Nitric Oxide; Probability; Random Allocation; Rats; Rats, Wistar	2008
Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells. Toxicon : official journal of the International Society on Toxinology, 2008, Aug-01, Volume: 52, Issue:2 Topics: Acetylcysteine; Apoptosis; Caspases; Cell Line, Tumor; Cobra Cardiotoxin Proteins; Cyclosporine; Cytochromes c; Elapid Venoms; Enzyme Activation; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Uncoupling Agents	2008
Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells. Molecular and cellular biochemistry, 2009, Volume: 320, Issue:1-2 Topics: Acetylcysteine; Allopurinol; Animals; Antimycin A; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cardiolipins; Cell Line, Tumor; Cyclosporine; Cytochromes c; Female; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Naphthoquinones; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rotenone; Uncoupling Agents; Vitamin K 3	2009
Interplay between Ca2+ cycling and mitochondrial permeability transition pores promotes reperfusion-induced injury of cardiac myocytes. Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:11 Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium; Cyclosporine; Fluoresceins; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Necrosis; Rats; Rats, Wistar; Reactive Oxygen Species; Ruthenium Compounds; Ryanodine; Thapsigargin; Tiopronin	2011
Acute liver failure and aplastic anemia in an 11-year-old girl. Digestive diseases and sciences, 2011, Volume: 56, Issue:8 Topics: Acetylcysteine; Anemia, Aplastic; Antilymphocyte Serum; Bilirubin; Child; Cyclosporine; Female; Humans; Immunosuppressive Agents; Liver Failure, Acute; Methylprednisolone Hemisuccinate; Platelet Transfusion; Prednisone; Transaminases; Treatment Outcome; Vitamin K	2011
The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells. European journal of medicinal chemistry, 2011, Volume: 46, Issue:7 Topics: Acetylcysteine; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; Caspases; Cell Line, Tumor; Cyclosporine; Cytochromes c; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Osteoblasts; Quinazolines; Reactive Oxygen Species; Signal Transduction	2011
Quantitative proteomic analysis of cyclosporine-induced toxicity in a human kidney cell line and comparison with tacrolimus. Journal of proteomics, 2011, Dec-21, Volume: 75, Issue:2 Topics: Acetylcysteine; Amino Acid Sequence; Basigin; Cell Survival; Cyclophilins; Cyclosporine; Endoplasmic Reticulum Stress; HEK293 Cells; Humans; Kidney; Lipid Peroxidation; Oxidative Stress; Proteomics; Tacrolimus; Up-Regulation	2011
Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection. Circulation, 2011, Dec-20, Volume: 124, Issue:25 Topics: Acetylcysteine; Animals; Cell Death; Cells, Cultured; Cyclosporine; Embryonic Stem Cells; Endothelial Cells; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Hematopoietic Stem Cells; Mice; Mice, Knockout; Mitochondria; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Sulfhydryl Compounds; Thioredoxin Reductase 1; Thioredoxin Reductase 2	2011
Novel multiple apoptotic mechanism of shikonin in human glioma cells. Annals of surgical oncology, 2012, Volume: 19, Issue:9 Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Catalase; Cell Line, Tumor; Cyclosporine; G1 Phase Cell Cycle Checkpoints; Glioma; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Naphthoquinones; Oxidative Stress; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Toluene; Tumor Suppressor Protein p53	2012
Chronic cyclosporine nephropathy is characterized by excessive autophagosome formation and decreased autophagic clearance. Transplantation, 2012, Aug-15, Volume: 94, Issue:3 Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antioxidants; Apoptosis; Autophagy; Caspase 3; Cyclosporine; Deoxyguanosine; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Kidney Diseases; Male; Mice; Microscopy, Electron; Microtubule-Associated Proteins; Oxidative Stress; Phagosomes; Pravastatin; Time Factors	2012
Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy. Diabetologia, 2012, Volume: 55, Issue:11 Topics: Acetylcysteine; Activating Transcription Factor 6; Apolipoproteins B; Apoptosis; Autophagy; Butylamines; Cell Survival; Cells, Cultured; Cyclosporine; Diabetic Retinopathy; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Glycosylation; Heat-Shock Proteins; Humans; Lipid Peroxidation; Lipoproteins, LDL; Mitochondria; Oxidative Stress; Pericytes; Poly I; Retina; Retinal Vessels	2012
The upregulation of transglutaminase-2 by cyclosporin a in human gingival fibroblasts is augmented by oxidative stress. Journal of periodontology, 2013, Volume: 84, Issue:10 Topics: Acetylcysteine; Adult; Antioxidants; Catechin; Cell Culture Techniques; Cells, Cultured; Chromones; Curcumin; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Free Radical Scavengers; Gingiva; GTP-Binding Proteins; Humans; Imidazoles; Immunosuppressive Agents; Male; Morpholines; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protease Inhibitors; Protein Glutamine gamma Glutamyltransferase 2; Pyridines; Reactive Oxygen Species; Transglutaminases; Up-Regulation	2013
The COPD Pipeline XXI. COPD, 2013, Volume: 10, Issue:2 Topics: Acetylcysteine; Clinical Trials as Topic; Cyclosporine; Drug Discovery; Humans; Orphan Drug Production; Pulmonary Disease, Chronic Obstructive; Research Design; Research Report; Rosiglitazone; Thiazolidinediones	2013
Influence of N-acetylcysteine on Klotho expression and its signaling pathway in experimental model of chronic cyclosporine nephropathy in mice. Transplantation, 2013, Jul-27, Volume: 96, Issue:2 Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antioxidants; Apoptosis; Chronic Disease; Cyclosporine; Deoxyguanosine; Disease Models, Animal; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression; Glucuronidase; Immunosuppressive Agents; Kidney Diseases; Klotho Proteins; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Proto-Oncogene Proteins c-akt; Signal Transduction; Superoxide Dismutase	2013
Evaluation of three-dimensional cultured HepG2 cells in a nano culture plate system: an in vitro human model of acetaminophen hepatotoxicity. Journal of pharmacological sciences, 2014, Volume: 124, Issue:2 Topics: Acetaminophen; Acetylcysteine; Anthracenes; Cells, Cultured; Cyclosporine; Cytochrome P-450 CYP2E1; Drug Evaluation, Preclinical; Glutathione; Hep G2 Cells; Humans; Liver; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Nanotechnology; Toxicity Tests	2014
Role of membrane cholesterol in spontaneous exocytosis at frog neuromuscular synapses: reactive oxygen species-calcium interplay. The Journal of physiology, 2014, Nov-15, Volume: 592, Issue:22 Topics: Acetophenones; Acetylcysteine; Animals; beta-Cyclodextrins; Calcium; Calcium Signaling; Capsaicin; Cholesterol; Cyclosporine; Exocytosis; Neuromuscular Junction; Okadaic Acid; Ranidae; Reactive Oxygen Species; Ruthenium Red; Synaptic Membranes; TRPV Cation Channels	2014
Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus. Clinical immunology (Orlando, Fla.), 2015, Volume: 160, Issue:2 Topics: Acetylcysteine; Adult; Alanine Transaminase; Antibodies, Antinuclear; Aspartate Aminotransferases; Azathioprine; Biomarkers; Cohort Studies; Complement System Proteins; Cyclosporine; Diabetes Mellitus; Female; Free Radical Scavengers; Humans; Immunosuppressive Agents; Liver Diseases; Longitudinal Studies; Lupus Erythematosus, Systemic; Male; Middle Aged; Mycophenolic Acid; Prednisone; Prevalence; Retrospective Studies; Severity of Illness Index; Sex Distribution; Sirolimus	2015
Mechanistic Approach for Toxic Effects of Bupropion in Primary Rat Hepatocytes. Drug research, 2017, Volume: 67, Issue:4 Topics: Acetylcysteine; alpha-Tocopherol; Animals; Antidepressive Agents, Second-Generation; Antioxidants; Bupropion; Cell Death; Cell Survival; Cyclosporine; Glutathione; Hepatocytes; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2017
Metabolic dependence of cyclosporine A on cell proliferation of human non‑small cell lung cancer A549 cells and its implication in post‑transplant malignancy. Oncology reports, 2019, Volume: 41, Issue:5 Topics: A549 Cells; Acetylcysteine; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cyclosporine; Energy Metabolism; Free Radical Scavengers; Glucose; Graft Rejection; Humans; Immunosuppressive Agents; Lung Neoplasms; Organ Transplantation; Palmitic Acid; Reactive Oxygen Species; Signal Transduction	2019
Blockade of Cyclophilin D Attenuates Oxidative Stress-Induced Cell Death in Human Dental Pulp Cells. Oxidative medicine and cellular longevity, 2019, Volume: 2019 Topics: Acetylcysteine; Apoptosis; Cyclosporine; Dental Pulp; Humans; Hydrogen Peroxide; Mitochondria; Oxidative Stress; Peptidyl-Prolyl Isomerase F; RNA, Small Interfering	2019
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice. Ultrastructural pathology, 2021, Jan-02, Volume: 45, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Liver; Mice	2021
[Treatment of thrombotic thrombocytopenic purpura]. Terapevticheskii arkhiv, 2021, Jun-15, Volume: 93, Issue:6 Topics: Acetylcysteine; Bortezomib; Child; Cyclosporine; Humans; Plasma Exchange; Purpura, Thrombotic Thrombocytopenic; Rituximab	2021