acetylcysteine has been researched along with cycloheximide in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.37) | 18.7374 |
| 1990's | 23 (31.51) | 18.2507 |
| 2000's | 38 (52.05) | 29.6817 |
| 2010's | 10 (13.70) | 24.3611 |
| 2020's | 1 (1.37) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Brüderlein, S; Gebhart, E; Tittelbach, H | 1 |
| Bellesia, E; Biondo, L; Cossarizza, A; Franceschi, C; Malorni, W; Monti, D; Rainaldi, G; Rivabene, R; Salvioli, S; Tinari, A | 1 |
| Baraban, JM; Murphy, TH; Ratan, RR | 1 |
| Godleski, JJ; Paulauskis, JD; Shi, MM | 1 |
| Chiba, T; Ishii, S; Kikuchi, K; Sato, N; Takahashi, S | 1 |
| Kim, HS; Kim, IK; Lee, JH | 1 |
| Blagosklonny, MV; el-Deiry, WS; Omura, S; Wu, GS | 1 |
| Bernard-Pomier, G; Charpentier, B; Déas, O; Dumont, C; Hirsch, F; Métivier, D; Mollereau, B; Pasquier, C; Senik, A | 1 |
| Duval, D; Froissard, P; Monrocq, H | 1 |
| An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L | 1 |
| Asahi, M; Che, W; Higashiyama, S; Kaneto, H; Okado, A; Takahashi, M; Taniguchi, N | 1 |
| Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T | 1 |
| Biber, J; Lederer, E; Murer, H; Pfister, MF; Ruf, I; Stange, G; Ziegler, U | 1 |
| Fox, ES; Leingang, KA | 1 |
| Alkon, DL; Favit, A; Grimaldi, M; Nelson, TJ | 1 |
| de Moissac, D; Greenberg, AH; Kirshenbaum, LA; Mustapha, S | 1 |
| Athias, A; Bessede, G; Gambert, P; Gueldry, S; Lemaire, S; Lizard, G; Miguet, C; Monier, S; Solary, E; Sordet, O | 1 |
| Chua, BH; Chua, CC; Hamdy, RC | 1 |
| Oberley, LW; Oberley, TD; Thongphasuk, J | 1 |
| Boulaire, J; Cannella, D; Fitzgerald, P; Fotedar, A; Fotedar, R; Rousseau, D | 1 |
| Gwag, BJ; Kang, JS; Kim, EY; Kim, HR; Noh, JS; Oh, YJ | 1 |
| Lee, MS; Lim, IK; Seo, MS | 1 |
| Mertz, K; Morgan, JI; Schmidt, J | 1 |
| Amara, SG; Daniels, GM | 1 |
| Fayadat, L; Franc, JL; Lanet, J; Siffroi-Fernandez, S | 1 |
| Groscurth, P; Hermisson, M; Krammer, PH; Liston, P; Wagenknecht, B; Weller, M | 1 |
| Levine, L | 1 |
| Antonicelli, F; Donaldson, K; Hirani, N; MacNee, W; Parmentier, M; Rahman, I | 1 |
| Cork, J; Joshi, MS; Kolls, JK; Lancaster, JR; Oliver, P; Schwarzenberger, PO; Zhang, Z | 1 |
| Ash, K; Tsang, BK; Xiao, CW | 1 |
| Kawamura, Y; Kikuchi, A; Komano, H; Shibamoto, S; Sudoh, S; Takada, R; Takada, S; Yanagisawa, K | 1 |
| Akahane, K; Minami, M; Ramesh, M; Sharma, VM; Venkateswarlu, A | 1 |
| Ahlemeyer, B; Becker, A; Klumpp, S; Krieglstein, J; Ravati, A | 1 |
| Braun, U; Camacho, F; Diaz-Meco, MT; Duran, A; García, JF; Leitges, M; Martin, P; Moscat, J; Rennert, PD; Sanz, L | 1 |
| Kimura, G; Ohtsu, M; Okuda, A | 1 |
| Brown, AD; Chaurasia, SS; Haque, R; Iuvone, PM; Klein, DC; Ma, M; Weller, J; Zawilska, JB | 1 |
| Dai, W; Darzynkiewicz, Z; Jhanwar-Uniyal, M; Liu, T; Luo, L; Ruan, Q; Traganos, F; Wang, Q; Xie, S | 1 |
| Bessho, Y; Harada, T; Hirata, H; Kageyama, R; Ohtsuka, T; Yoshikawa, K; Yoshiura, S | 1 |
| Gauthier, ER; Guérin, PJ | 1 |
| Dietrich, W; Huber, JC; Kolbus, A; Stonek, F; Tschugguel, W; Zhegu, Z | 1 |
| Alaoui-Jamali, MA; Igdoura, SA; Laird, DW; Qin, H; Shao, Q | 1 |
| Bhattacharya, S; Calbó, J; Garriga, J; Graña, X; Haines, DS; Marshall, RM; Truongcao, M | 1 |
| Franklin, JL; Kirkland, RA | 1 |
| Harris, RC; Singh, AB | 1 |
| Desaki, M; Kawasaki, S; Kohyama, T; Okazaki, H; Takizawa, H; Yamamoto, K; Yamauchi, Y | 1 |
| Jung, MJ; Kweon, MH; Sung, HC | 1 |
| Cullen, DA; Gallo, JM; Leigh, PN | 1 |
| Antonicelli, F; Brown, D; Donaldson, K; Drost, EM; Hirani, N; MacNee, W; Parmentier, M; Rahman, I | 1 |
| Dehnade, F; Li, WQ; Liacini, A; Qureshi, HY; Zafarullah, M | 1 |
| Bonanou, S; Chachami, G; Hatziefthimiou, A; Molyvdas, PA; Paraskeva, E; Simos, G | 1 |
| Bulla, GA; Kraus, DM; Schmitz, EK | 1 |
| Fujiwara, N; Koh, YH; Misonou, Y; Miyamoto, Y; Park, YS; Suzuki, K; Takahashi, M; Taniguchi, N | 1 |
| Ahmad, R; Blackinton, J; Canet-Avilés, RM; Cookson, MR; Hague, SM; Kaleem, M; Miller, DW; van der Brug, MP | 1 |
| Kawatani, Y; Minegishi, N; Shimizu, R; Suzuki, N; Yamamoto, M | 1 |
| Aiuchi, T; Ann, WW; Itabe, H; Nakajo, S; Nakaya, K; Sakairi, S; Shibayama-Imazu, T; Sonoda, I | 1 |
| Deng, L; Frank, SJ; Fuchs, SY; He, K; Jiang, J; Thangavel, C; Wang, X; Yang, N | 1 |
| Jin, S; Johnson, LR; Ray, RM | 1 |
| Staszczak, M | 1 |
| Gorospe, M; Kawai, T; Otto, K; Rinker-Schaeffer, CW; Robinson, VL; Shalhav, O | 1 |
| Campos, EI; Garate, M; Li, G; Wang, Y; Wong, RP | 1 |
| Baek, SJ; Eling, TE; Hara, Y; Lee, SH; McEntee, MF; Sukhthankar, M; Yamaguchi, K | 1 |
| Bengtén, E; Kountikov, E; Miller, NW; Nayak, D; Wilson, M | 1 |
| Kim, SY; Park, JW | 1 |
| Arawaka, S; Fukushima, S; Hara, S; Kato, T; Koyama, S; Machiya, Y; Sakamoto, M; Sato, H | 1 |
| Alvarez-Velilla, R; Balaña-Fouce, R; Estrada, CG; Pérez-Pertejo, Y; Reguera, RM | 1 |
| Baltrusch, S; Hofmeister-Brix, A; Lenzen, S | 1 |
| Ishigaki, Y; Matsunaga, T; Nakagawa, H; Nogawa, A; Takegami, T; Zhao, X | 1 |
| Bruni, E; Caputo, F; De Nicola, M; Ghibelli, L; González-Flores, D; Pariente, JA; Rodríguez, AB | 1 |
| Chang, JL; Cheng, CW; Chien, MH; Chow, JM; Hsiao, M; Lai, GM; Lee, LM; Lee, WJ; Lin, YW; Wen, YC | 1 |
| Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Costa, VM; Feio-Azevedo, R; Ferreira, LM; Pereira, FC | 1 |
| Hou, Y; Ji, X; Jiang, H; Leng, X; Settlage, R | 1 |
73 other study(ies) available for acetylcysteine and cycloheximide
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
The activity of bleomycin and modifiers of its clastogenic effect on the interphase chromatin of Indian muntjak fibroblasts.
Topics: Acetylcysteine; Animals; beta-Aminoethyl Isothiourea; Bleomycin; Cell Line; Chromatin; Chromosome Aberrations; Cycloheximide; Deer; Fibroblasts; Interphase; Male; Metaphase; Mutagens | 1989 |
Protective effect of N-acetylcysteine in tumor necrosis factor-alpha-induced apoptosis in U937 cells: the role of mitochondria.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Benzimidazoles; Carbocyanines; Cycloheximide; DNA Damage; Flow Cytometry; Fluorescent Dyes; Homeostasis; Humans; Leukemia, Myelomonocytic, Acute; Membrane Potentials; Mitochondria; Monocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cells, Cultured; Cerebral Cortex; Cycloheximide; Cysteine; Glutamates; Glutathione; Homocysteine; Macromolecular Substances; Methionine Sulfoximine; Neurons; Oxidants; Protein Biosynthesis; Proteins; Rats | 1994 |
Regulation of macrophage inflammatory protein-1alpha mRNA by oxidative stress.
Topics: Acetylcysteine; Animals; Blotting, Northern; Cell Nucleus; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Cycloheximide; Dactinomycin; Gene Expression Regulation; Growth Inhibitors; Hydrogen Peroxide; Kinetics; Macrophage Inflammatory Proteins; Macrophages, Alveolar; Monokines; Oxidative Stress; Rats; RNA, Messenger; Time Factors; Transcription, Genetic; Vitamin K | 1996 |
Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Culture Media, Conditioned; Cycloheximide; Cysteine; Cytotoxicity, Immunologic; fas Receptor; Glutathione; Humans; Immunity, Innate; Intracellular Fluid; Killer Cells, Lymphokine-Activated; Leukemia, T-Cell; Lymphocyte Activation; Methionine Sulfoximine; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenites; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Division; Cycloheximide; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glutathione; Humans; Liver Neoplasms; Prostaglandin D2; Sodium Compounds; Structure-Activity Relationship; Sulfhydryl Compounds; Tumor Cells, Cultured | 1996 |
Proteasome-dependent regulation of p21WAF1/CIP1 expression.
Topics: Acetylcysteine; Cell Line; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Luciferases; Multienzyme Complexes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Protein Biosynthesis; Recombinant Proteins; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1996 |
Thiol-mediated inhibition of FAS and CD2 apoptotic signaling in activated human peripheral T cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; CD2 Antigens; Cells, Cultured; Cycloheximide; Dactinomycin; fas Receptor; Female; Glutathione; Humans; Lymphocyte Activation; Male; Signal Transduction; Sulfhydryl Compounds; T-Lymphocytes | 1997 |
Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Culture Media, Serum-Free; Cycloheximide; Cystine; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Neurons; Oxidative Stress; PC12 Cells; Protein Synthesis Inhibitors; Rats | 1997 |
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Cell Nucleus; Cells, Cultured; Cycloheximide; Dactinomycin; Deoxyglucose; Diabetic Angiopathies; Epidermal Growth Factor; Gene Expression; Guanidines; Heparin; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Kinetics; Muscle, Smooth, Vascular; Peroxides; Pyruvaldehyde; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Transcription, Genetic | 1997 |
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Compartmentation; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kidney; Leupeptins; Lysosomes; Microscopy, Confocal; Multienzyme Complexes; Opossums; Parathyroid Hormone; Phosphates; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters | 1998 |
Inhibition of LPS-mediated activation in rat Kupffer cells by N-acetylcysteine occurs subsequent to NF-kappaB translocation and requires protein synthesis.
Topics: Acetylcysteine; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kupffer Cells; Lipopolysaccharides; Macrophage Activation; Male; NF-kappa B; Okadaic Acid; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factor RelB; Transcription Factors; Tumor Necrosis Factor-alpha | 1998 |
Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Brain; Cells, Cultured; Cycloheximide; Fibroblasts; Humans; Isoenzymes; Peptide Fragments; Protein Kinase C; Protein Kinase C-alpha; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate | 1998 |
Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Cell Line; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Heart Ventricles; Humans; I-kappa B Proteins; Multienzyme Complexes; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 1998 |
Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Caspases; Cycloheximide; Cytochrome c Group; DNA Fragmentation; Enzyme Activation; Enzyme Precursors; Etoposide; Fatty Acids, Unsaturated; Free Radicals; Glutathione; Humans; Ketocholesterols; Oxidation-Reduction; Reactive Oxygen Species; U937 Cells | 1998 |
Upregulation of vascular endothelial growth factor by H2O2 in rat heart endothelial cells.
Topics: Acetylcysteine; Animals; Antioxidants; Blotting, Northern; Cells, Cultured; Cycloheximide; Dactinomycin; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation; Heart; Hydrogen Peroxide; Kinetics; Lymphokines; Protein Kinase Inhibitors; Protein Kinases; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Survival; Chlorides; Citrate (si)-Synthase; Cyclic N-Oxides; Cycloheximide; Enzyme Induction; Female; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Manganese Compounds; Manganese Poisoning; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Hemagglutinins; Humans; Leupeptins; Mice; Models, Genetic; Multienzyme Complexes; Mutagenesis; Osteosarcoma; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitins | 1999 |
Neurotoxic and neuroprotective actions of catecholamines in cortical neurons.
Topics: Acetylcysteine; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cardiotonic Agents; Catecholamines; Cell Survival; Cells, Cultured; Cerebral Cortex; Cycloheximide; DNA Damage; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; Fetus; Free Radicals; Lipid Peroxidation; Mice; Neurons; Norepinephrine; Potassium; Protein Synthesis Inhibitors; Sympathomimetics | 1999 |
Expression of rat BTG(3) gene, Rbtg3, is regulated by redox changes.
Topics: 3' Untranslated Regions; 3T3 Cells; 5' Untranslated Regions; Acetylcysteine; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Cycloheximide; DNA, Complementary; Free Radical Scavengers; Gene Expression Regulation; Genes, Tumor Suppressor; Hydrogen Peroxide; Immediate-Early Proteins; Mice; Molecular Sequence Data; Oxidation-Reduction; PC12 Cells; Proteins; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 1999 |
Regulation of heme oxygenase-1 expression by dopamine in cultured C6 glioma and primary astrocytes.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Ascorbic Acid; Astrocytes; Catechol O-Methyltransferase Inhibitors; Catechols; Cell Line; Cycloheximide; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glioma; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Membrane Proteins; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; RNA, Messenger; Selegiline; Time Factors; Tumor Cells, Cultured | 1999 |
Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chloroquine; Clathrin; Colforsin; Cycloheximide; Dogs; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Enzyme Activation; Humans; Kinetics; Lysosomes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Degradation of human thyroperoxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the protein.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Antibodies, Monoclonal; Chloroquine; CHO Cells; Cricetinae; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Emetine; Endoplasmic Reticulum; Humans; Multienzyme Complexes; Peroxidase; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Folding; Thyroid Gland | 2000 |
Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Caspases; Cell Survival; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Glioma; Humans; Lactams; Leupeptins; Membrane Glycoproteins; Mice; Mitochondria; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Transgenes; Tumor Cells, Cultured | 2000 |
Lactacystin stimulates arachidonic acid metabolism in rat liver cells: effects of cell density on arachidonic acid release, PGI2 production and cyclooxygenase activity.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Cell Count; Cells, Cultured; Contact Inhibition; Culture Media, Serum-Free; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Epoprostenol; Hepatocytes; Multienzyme Complexes; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 2000 |
Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells.
Topics: Acetylcysteine; Cell Line; Cycloheximide; Enzyme Inhibitors; Glutathione; Humans; Interleukin-1; Lipopolysaccharides; Macrophages; NF-kappa B; Okadaic Acid; Protein Isoforms; Protein Synthesis Inhibitors; RNA, Messenger | 2000 |
Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate.
Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Antigens, CD; Antioxidants; Cell Line; Cycloheximide; Dipeptides; Enzyme Activation; Humans; Hydrogen Peroxide; Hydroxamic Acids; Jurkat Cells; Metalloendopeptidases; Models, Biological; Monocytes; Protease Inhibitors; Reactive Oxygen Species; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Nuclear factor-kappaB-mediated X-linked inhibitor of apoptosis protein expression prevents rat granulosa cells from tumor necrosis factor alpha-induced apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Biological Transport; Cycloheximide; Down-Regulation; Drug Synergism; Female; Granulosa Cells; NF-kappa B; Peptides; Proteins; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; X-Linked Inhibitor of Apoptosis Protein | 2001 |
Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation.
Topics: Acetylcysteine; Animals; beta Catenin; Culture Media, Conditioned; Cycloheximide; Cytoskeletal Proteins; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Membrane Proteins; Mice; Mutation; Phosphorylation; Presenilin-1; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins; Signal Transduction; Time Factors; Trans-Activators; Transfection; Tumor Cells, Cultured; Wnt Proteins; Wnt3 Protein; Wnt3A Protein; Zebrafish Proteins | 2001 |
Antitumor bicyclic hexapeptide RA-VII modulates cyclin D1 protein level.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Blotting, Northern; Blotting, Western; Cell Cycle; Cyclin D1; Cycloheximide; Cysteine Proteinase Inhibitors; Formazans; Humans; Peptides, Cyclic; Protein Synthesis Inhibitors; RNA, Messenger; Tetrazolium Salts; Tumor Cells, Cultured | 2001 |
Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Astrocytes; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Ferrous Compounds; Hippocampus; Immunoblotting; Immunohistochemistry; Neurons; NF-kappa B; Protein Synthesis Inhibitors; Rats; Rats, Inbred F344; Reactive Oxygen Species; Staurosporine; Superoxide Dismutase; Xanthine; Xanthine Oxidase | 2001 |
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Enzyme Activation; Female; Fibroblasts; Gene Targeting; Genes, Reporter; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Lung; Lymphocyte Subsets; Male; Mice; Mice, Knockout; NF-kappa B; NF-KappaB Inhibitor alpha; Peyer's Patches; Phenotype; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Recombinant Proteins; Spleen; Transcription Factor RelA; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein.
Topics: Acetylcysteine; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genetic Complementation Test; Hybrid Cells; Leupeptins; Multienzyme Complexes; Point Mutation; Proteasome Endopeptidase Complex; Proteins; Rats; Temperature; Ubiquitin | 2001 |
Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase.
Topics: Acetylcysteine; Animals; Arylamine N-Acetyltransferase; Blotting, Western; Chickens; Circadian Rhythm; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Male; Melatonin; Multienzyme Complexes; Photic Stimulation; Pineal Gland; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Rabbits; Retina | 2002 |
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
Topics: Acetylcysteine; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Cysteine Endopeptidases; Doxorubicin; Fibroblasts; HeLa Cells; Humans; Hydrogen Peroxide; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oxidative Stress; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Reactive Oxygen Species | 2002 |
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
Topics: Acetylcysteine; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Blood; Cell Line; Cycloheximide; Cysteine Endopeptidases; Feedback, Physiological; Gene Expression Regulation; Glycosyltransferases; Half-Life; Homeodomain Proteins; Leupeptins; Mesoderm; Mice; Multienzyme Complexes; PC12 Cells; Periodicity; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Transcription Factor HES-1; Transcription, Genetic; Transfection; Ubiquitin | 2002 |
Induction of cellular necrosis by the glutathione peroxidase mimetic ebselen.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Apoptosis; Azoles; Caspases; Cell Death; Cycloheximide; Cysteine Proteinase Inhibitors; Glutathione Peroxidase; Hybridomas; Isoindoles; Mice; Necrosis; Organoselenium Compounds | 2003 |
Differential regulation of proteasome-dependent estrogen receptor alpha and beta turnover in cultured human uterine artery endothelial cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Antibody Specificity; Arteries; Blotting, Western; Cell Nucleus; Cell-Free System; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation; Humans; Insulin; Kinetics; Multienzyme Complexes; Proteasome Endopeptidase Complex; Puromycin; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Uterus | 2003 |
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.
Topics: Acetylcysteine; Animals; Blotting, Western; Breast Neoplasms; Brefeldin A; Cell Communication; Cell Membrane; Connexin 43; Cycloheximide; Cysteine Endopeptidases; Gap Junctions; Humans; Immunohistochemistry; Lysosomes; Mammary Neoplasms, Animal; Microscopy, Confocal; Microscopy, Electron; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Protein Transport; Rats; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2003 |
CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.
Topics: Acetylcysteine; Adenoviridae; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; HeLa Cells; Humans; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; RNA Interference; S-Phase Kinase-Associated Proteins; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
Prooxidant effects of NGF withdrawal and MEK inhibition in sympathetic neurons.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cycloheximide; Fetus; Flavonoids; Glutathione; MAP Kinase Signaling System; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factor; Neurons; Pyrazoles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superior Cervical Ganglion; Sympathetic Nervous System | 2003 |
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.
Topics: Acetylcysteine; Adherens Junctions; Animals; Blotting, Northern; Bromodeoxyuridine; Cell Adhesion; Cell Differentiation; Cell Division; Cell Line; Claudin-1; Claudin-3; Claudin-4; Claudins; Cycloheximide; Detergents; Dogs; Epithelium; ErbB Receptors; Gene Expression Regulation; Hepatocyte Growth Factor; Immunoblotting; Kidney; Membrane Proteins; Microscopy, Fluorescence; Neoplasms; Octoxynol; Phenotype; Protein Synthesis Inhibitors; Signal Transduction; Tight Junctions; Time Factors | 2004 |
Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.
Topics: Acetylcysteine; Bronchi; Cell Line; Cycloheximide; Epithelial Cells; Folic Acid Antagonists; Free Radical Scavengers; Glucose; Humans; Hypoglycemia; Interleukin-1; Interleukin-8; Lipopolysaccharides; Methotrexate; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Pulmonary Alveoli; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Cytoprotective effects of heme oxygenase-1 induction by 3-O-caffeoyl-1-methylquinic acid.
Topics: Acetylcysteine; Animals; Antioxidants; Cattle; Cell Line; Cryoprotective Agents; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Ferritins; Flow Cytometry; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxybenzoates; Molecular Structure; Necrosis; Protoporphyrins; Quinic Acid; Reactive Oxygen Species; RNA, Messenger; tert-Butylhydroperoxide; Time Factors; Up-Regulation | 2004 |
Degradation properties of polyglutamine-expanded human androgen receptor in transfected cells.
Topics: Acetylcysteine; Anti-Bacterial Agents; Blotting, Western; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Doxycycline; Drug Interactions; Embryo, Mammalian; Fluorescent Antibody Technique; Gene Expression; Humans; Kidney; Peptides; Protein Synthesis Inhibitors; Receptors, Androgen; Time Factors; Transfection | 2004 |
Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn.
Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Chemotaxis; Cycloheximide; Enzyme Inhibitors; Gene Expression; Humans; In Vitro Techniques; Interleukin-8; Lipopolysaccharides; Lysine; Male; Monocytes; Neutrophils; Okadaic Acid; Pneumonia; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors | 2004 |
Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Azoles; Blotting, Northern; Blotting, Western; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Culture Media, Serum-Free; Cycloheximide; DNA-Binding Proteins; Down-Regulation; Free Radicals; Growth Substances; Humans; Hydrogen Peroxide; Isoindoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Oligonucleotides, Antisense; Organoselenium Compounds; Oxidation-Reduction; Phosphorylation; Reactive Oxygen Species; RNA; RNA, Messenger; Signal Transduction; Smad2 Protein; Species Specificity; Time Factors; Tissue Inhibitor of Metalloproteinase-3; Trans-Activators; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism.
Topics: Acetylcysteine; Androstadienes; Animals; Blotting, Western; Cell Nucleus; Chromones; Cobalt; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microscopy, Fluorescence; Models, Biological; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Plasmids; Potassium Chloride; Rabbits; Reactive Oxygen Species; Time Factors; Trachea; Transcription Factors; Transcription, Genetic; Transfection; Wortmannin | 2004 |
Tissue-specificity of apoptosis in hepatoma-derived cell lines.
Topics: Acetylcysteine; alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Cycloheximide; Electrophoretic Mobility Shift Assay; Interleukin-1; Lipopolysaccharides; Liver Neoplasms; Protein Synthesis Inhibitors; Rats; Sorbitol; Transgenes; Tumor Necrosis Factor-alpha; Vinblastine; Vincristine | 2004 |
Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Acrolein; Antioxidants; Cells, Cultured; Cycloheximide; Dactinomycin; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Humans; Oxidative Stress; RNA, Messenger; Thioredoxin-Disulfide Reductase; Umbilical Veins | 2005 |
Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization.
Topics: Acetylcysteine; Ammonium Chloride; Analysis of Variance; Animals; Blotting, Western; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Dimerization; Fluorescent Antibody Technique; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mice; Models, Molecular; Neuroblastoma; Oncogene Proteins; Point Mutation; Polymorphism, Genetic; Protein Deglycase DJ-1; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Subcellular Fractions; Time Factors; Transfection | 2005 |
Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Deletion; Gene Expression Regulation; Half-Life; Humans; Leukemia, Experimental; Leupeptins; Mice; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Ubiquitins; Ultraviolet Rays | 2005 |
Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; alpha-Tocopherol; Apoptosis; Cycloheximide; Diterpenes; Female; Humans; Membrane Potentials; Mitochondria; Ovarian Neoplasms; Reactive Oxygen Species; Superoxides; Tumor Cells, Cultured; Vitamin K 2 | 2006 |
Determinants of growth hormone receptor down-regulation.
Topics: Acetylcysteine; Animals; Cell Line; Chloroquine; Cycloheximide; Down-Regulation; Human Growth Hormone; Humans; Janus Kinase 2; Lysosomes; Mice; Mutation; Phosphorylation; Proteasome Inhibitors; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Rabbits; Receptors, Somatotropin; Recombinant Proteins; Transfection; Tyrosine | 2007 |
TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species.
Topics: Acetylcysteine; Aminoquinolines; Animals; Antioxidants; Apoptosis; Caspase 3; Cell Line; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Hydrogen Peroxide; Intestinal Mucosa; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; NADPH Oxidases; Onium Compounds; Oxidants; Oxidative Stress; Pyrimidines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Rotenone; Signal Transduction; Tumor Necrosis Factor-alpha; Uncoupling Agents | 2008 |
The role of the ubiquitin-proteasome system in the response of the ligninolytic fungus Trametes versicolor to nitrogen deprivation.
Topics: Acetylcysteine; Blotting, Western; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Iodine Radioisotopes; Laccase; Lignin; Nitrogen; Polyporales; Proteasome Endopeptidase Complex; Ubiquitin | 2008 |
Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines.
Topics: Acetylcysteine; Blotting, Northern; Cell Line, Tumor; Cycloheximide; Dactinomycin; Ethanol; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase 4; Neoplasm Metastasis; Ovarian Neoplasms; Polymerase Chain Reaction; Prostatic Neoplasms; Protein Biosynthesis | 2008 |
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
Topics: Acetylcysteine; Animals; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Leupeptins; NAD(P)H Dehydrogenase (Quinone); Nuclear Proteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine; Tumor Suppressor Proteins; Ultraviolet Rays | 2008 |
A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.
Topics: Acetylcysteine; Adenomatous Polyposis Coli; Animals; Antineoplastic Agents, Phytogenic; Camellia sinensis; Catechin; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cycloheximide; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Fibroblast Growth Factor 2; Genes, APC; HCT116 Cells; HT29 Cells; Humans; Mice; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Time Factors; Transfection | 2008 |
Expression of alternatively spliced CD45 isoforms by channel catfish clonal T and B cells is dependent on activation state of the cell and regulated by protein synthesis and degradation.
Topics: Acetylcysteine; Alternative Splicing; Animals; B-Lymphocytes; Clone Cells; Concanavalin A; Cycloheximide; Feedback, Physiological; Gene Expression Profiling; Ictaluridae; Immunization; Leukocyte Common Antigens; Lymphocyte Activation; Protein Isoforms; T-Lymphocytes | 2010 |
Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase.
Topics: Acetylcysteine; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Isocitrate Dehydrogenase; Leupeptins; Mitochondrial Proteins; Phosphatidylinositol 3-Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sp1 Transcription Factor | 2010 |
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Line, Tumor; Cerebral Cortex; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lewy Bodies; Neurons; Okadaic Acid; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Protein Synthesis Inhibitors; Rabbits; Ubiquitin | 2010 |
Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.
Topics: Acetylcysteine; Cell Culture Techniques; Cloning, Molecular; Cycloheximide; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Gene Expression; Immunoprecipitation; Kinetics; Leishmania donovani; Leishmaniasis, Visceral; Leupeptins; Methionine Adenosyltransferase; Oligopeptides; Plasmids; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; S-Adenosylmethionine; Transfection; Ubiquitin | 2011 |
The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
Topics: Acetylcysteine; Animals; Chlorocebus aethiops; COS Cells; Cycloheximide; Glucokinase; Glucose; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leupeptins; Mice; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Single-Cell Analysis; Ubiquitin; Ubiquitination | 2013 |
Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells.
Topics: Acetylcysteine; Androstadienes; Cycloheximide; Exons; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Nonsense Mediated mRNA Decay; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteasome Inhibitors; Protein Serine-Threonine Kinases; RNA Helicases; RNA-Binding Proteins; RNA, Small Interfering; Trans-Activators; Transcription Factors; Ubiquitin; Wortmannin | 2014 |
Nanoceria protects from alterations in oxidative metabolism and calcium overloads induced by TNFα and cycloheximide in U937 cells: pharmacological potential of nanoparticles.
Topics: Acetylcysteine; Antifungal Agents; Apoptosis; Calcium; Cerium; Chromans; Cycloheximide; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Nanoparticles; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; U937 Cells | 2014 |
Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Curcumin; Cycloheximide; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Immunohistochemistry; Male; Mice; Mice, SCID; Microtubule-Associated Proteins; Prostatic Neoplasms; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Transcription Factor CHOP; Transplantation, Heterologous; Vacuoles | 2015 |
Toxicity of the amphetamine metabolites 4-hydroxyamphetamine and 4-hydroxynorephedrine in human dopaminergic differentiated SH-SY5Y cells.
Topics: Acetylcysteine; Amphetamine; Apoptosis; Carnitine; Cell Differentiation; Cell Line; Cell Survival; Cycloheximide; Dopaminergic Neurons; Dose-Response Relationship, Drug; Humans; Lethal Dose 50; Methylphenidate; p-Hydroxyamphetamine; p-Hydroxynorephedrine; Reactive Oxygen Species | 2017 |
Roles of the proteasome and inhibitor of DNA binding 1 protein in myoblast differentiation.
Topics: Acetylcysteine; Animals; Cattle; Cell Differentiation; Cycloheximide; Gene Expression Regulation, Developmental; Inhibitor of Differentiation Protein 1; Male; Muscle Proteins; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Messenger; Satellite Cells, Skeletal Muscle; Sequence Analysis, RNA; Ubiquitination | 2019 |