acetylcysteine has been researched along with curcumin in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.03) | 18.7374 |
| 1990's | 1 (1.03) | 18.2507 |
| 2000's | 25 (25.77) | 29.6817 |
| 2010's | 59 (60.82) | 24.3611 |
| 2020's | 11 (11.34) | 2.80 |
| Authors | Studies |
|---|---|
| Du, XM; Guo, SJ; Liu, GY; Sun, YZ; Yang, J; Zhou, N | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Newmark, HL; Wargovich, MJ | 1 |
| Grant, S; Vrana, JA | 1 |
| Chen, YC; Lee, WR; Lin, JK; Shen, SC; Tsai, SH | 1 |
| Akrishnan, VR; Menon, VP | 1 |
| Calabrese, V; Foresti, R; Giuffrida Stella, AM; Green, CJ; Motterlini, R; Scapagnini, G | 1 |
| Aggarwal, BB; Banerjee, S; Liu, M; Mukhopadhyay, A; Stafford, LJ; Xia, C | 1 |
| Li, WQ; Liacini, A; Sylvester, J; Zafarullah, M | 1 |
| Huang, WT; Lee, JJ; Liao, JF; Lin, MT; Shao, DZ | 1 |
| Li, L; Renier, G; Sawamura, T | 1 |
| Akhand, AA; Dai, Y; Du, J; Hayakawa, A; Hossain, K; Nakashima, I; Rifa'i, M; Suzuki, H; Takeda, K; Tsuboi, H | 1 |
| Chen, J; Kang, J; Liu, Q; Wanming, D; Zhang, D | 1 |
| Guzdek, A; Koj, A; Rokicki, M; Stalińska, K | 1 |
| Assi, K; Gómez-Muñoz, A; Moussavi, M; Salh, B | 1 |
| Choi, KS; Jung, EM; Kwon, TK; Lee, HI; Lee, KS; Park, JW | 1 |
| Bhat, GJ; Niture, SK; Smith, QR; Srivenugopal, KS; Velu, CS | 1 |
| Bai, H; Chen, J; Kang, J; Wang, C | 1 |
| Cavallaro, LG; Cavestro, GM; Comparato, G; Di Mario, F; Fanigliulo, L; Franzè, A; Iori, V; Leandro, G; Maino, M; Martelli, L; Martelli, M; Morana, E; Nouvenne, A; Pilotto, A; Stefani, N | 1 |
| Kim, M; Murakami, A; Ohigashi, H | 1 |
| Austin, CA; Curtis, H; Gilroy, KL; Jobson, A; López-Lázaro, M; Padget, K; Willmore, E | 1 |
| Mutsaers, HA; Pennings, SW; Russel, FG; Scharstuhl, A; Szarek, WA; Wagener, FA | 1 |
| Chen, D; Dou, QP; Landis-Piwowar, KR; Milacic, V; Yang, H | 1 |
| Cheng, SE; Hsieh, HL; Jou, MJ; Kou, YR; Lee, IT; Lin, CC; Luo, SF; Yang, CM | 1 |
| Krishna, M; Kunwar, A; Priyadarsini, KI; Sandur, SK | 1 |
| Baruchello, R; D'Alessandro, N; Gueli, MC; Labbozzetta, M; Marchetti, P; Notarbartolo, M; Poma, P; Simoni, D | 1 |
| Ahmed, RS; Ahmed, T; Banerjee, BD; Das, S; Kumar, V; Suke, SG; Tripathi, AK | 1 |
| Anantharam, V; Bravosanpedro, JM; Fuentes, JM; González-Polo, RA; Kanthasamy, AG; Morán, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G | 1 |
| Dehpour, AR; Javidnia, K; Kheradpezhouh, E; Miri, R; Monabati, A; Noorafshan, A; Panjehshahin, MR | 1 |
| Kawakami, T; Kirita, T; Morisugi, T; Tanaka, Y | 1 |
| Chan, HW; Chen, HH; Chiu, LY; Hsin, IL; Hsu, CP; Ko, JL; Sheu, GT; Wang, HD | 1 |
| Ayli, EE; Dugas-Breit, S; Gelfand, JM; Griffin, T; Li, W; Marshall, C; Meulener, M; Seykora, JT; Zhao, L | 1 |
| Alleyne, CH; Dhandapani, KM; Laird, MD; Singh, N; Sukumari-Ramesh, S; Vender, JR | 1 |
| Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yang, SF | 1 |
| Lima, CF; Pereira-Wilson, C; Rattan, SI | 1 |
| Ahmed, RS; Ahmed, T; Banerjee, BD; Kar, R; Mustafa, MD; Pathak, R; Tripathi, AK | 1 |
| Green, KN; Hendrix, C; LaFerla, FM; Parachikova, A | 1 |
| El-Agamy, DS; Said, SA | 1 |
| Karayakar, F; Karaytug, S; Sevgiler, Y | 2 |
| Lee, CW; Lee, HC; Lee, IT; Lin, CC; Yang, CM | 1 |
| Chen, PY; Chung, JG; Ip, SW; Kuo, CL; Wu, PP; Wu, SH; Wu, SY; Yang, JS; Yu, CS | 1 |
| Forte, TM; Ghosh, M; Gordon, LI; Ryan, RO; Singh, AT | 1 |
| Abdalla, AM; Abdelwahab, SA; Mahmoud, AM; Mahmoud, ME; Morsy, MA | 1 |
| Amarapurkar, DN; Gupta, VH; Rai, G; Sasi, P; Singh, M; Wangikar, PP | 1 |
| Berger, F; Büchsler, I; Munz, B | 1 |
| Cho, TJ; Choi, KU; Kim, JY; Lee, CH; Park, HR; Ryu, MH; Woo, BH | 1 |
| El-Maraghy, SA; Hamdy, MA; Kortam, MA | 1 |
| Chang, YC; Huang, FM; Kuan, YH; Lee, SS; Tsai, CH | 1 |
| Chen, HT; Chiang, YC; Hsu, HC; Huang, PH; Tang, CH; Tsai, CH | 1 |
| Ehemann, V; Hagenlocher, C; Kluwe, L; Mautner, V; Mucha, J; Reuss, DE; von Deimling, A | 1 |
| Gao, JL; Hoi, PM; Lee, SM; Li, YB; Wang, YT; Zhong, ZF | 1 |
| Kaushik, G; Kaushik, T; Khanduja, KL; Pathak, CM; Ranawat, P; Sharma, SK; Yadav, SK | 1 |
| Guo, YL; Ji, J; Yu, T | 1 |
| Berkelhammer, J; Hopkins, S; Loo, G; Murphy, A; Testa, K | 1 |
| Fontani, F; Iantomasi, T; Marcucci, T; Picariello, L; Tonelli, F; Vincenzini, MT | 1 |
| García, A; González, C; Herrera, C; Salas-Jara, MJ | 1 |
| Carels, CE; Cremers, NA; Lundvig, DM; Regan, RF; Schelbergen, RF; Szarek, WA; van Dalen, SC; van Lent, PL; Wagener, FA | 1 |
| Deng, YT; Hsieh, YP; Kuo, MY; Wu, KJ; Yang, WH | 1 |
| Chang, JL; Cheng, CW; Chien, MH; Chow, JM; Hsiao, M; Lai, GM; Lee, LM; Lee, WJ; Lin, YW; Wen, YC | 1 |
| Al-Rubaei, ZM; Ali, LK; Mohammad, TU | 1 |
| Alonso-Varona, A; Azcoitia, I; Bastida, F; Castro, B; del Olmo, M; Palomares, T; Soldevilla, JJ | 1 |
| Aschner, M; Ben, L; Changsheng, Y; Fang, L; Guangwei, X; Hai, Q; Jing, M; Rongzhu, L; Shuhua, W; Wenjun, Z; Yu, B | 1 |
| Chatgilialoglu, C; Cort, A; Ferreri, C; Melchiorre, M; Ozben, T; Sansone, A | 1 |
| Li, J; Liu, D; Pan, W; Tan, G; Yang, X; Zhao, Z | 1 |
| Chattopadhyay, S; Khatri, R; Krishnan, S; Kumar, V; Mukhopadhyay, A; Roy, S | 1 |
| Bai, C; He, F; Li, J; Liu, D; Liu, Z; Pan, H; Wu, Q; Yang, X; Yu, S | 1 |
| Barbarite, E; Gersey, ZC; Graham, RM; Komotar, RJ; Ohaeto, KC; Rodriguez, GA; Sanchez, A; Walters, WM | 1 |
| Ding, Y; Liao, W; Wang, FF; Wang, R; Xiang, W | 1 |
| Asghar, S; Chen, Z; Huang, L; Kambere Amerigos, D; Ping, Q; Tian, C; Wu, Y; Xiao, Y; Yin, L; Zhang, M | 1 |
| El-Maddawy, ZK; El-Sayed, YS | 1 |
| Avola, R; Barbagallo, I; Distefano, A; Li Volti, G; Raffaele, M; Tibullo, D; Vanella, L; Zingales, V | 1 |
| Bastida, FD; Castro, B; López Casanova, P; Segovia, T; Soldevilla, JJ; Verdú-Soriano, J | 1 |
| Chen, G; Kang, X; Liu, TD; Zhang, JX; Zheng, BZ | 1 |
| Deng, Q; Duan, W; Jiang, Y; Liang, L; Liu, Q; Zhang, L | 1 |
| Moore, K | 1 |
| Li, Z; Liu, W; Yang, Y; Zhao, Z | 1 |
| Hu, Y; Lu, NH; Yang-Ou, YB; Zhu, Y | 1 |
| Ma, J; Ran, Z; Wen, X; Zhang, Y | 1 |
| Chokchaichamnankit, D; Hatairaktham, S; Kalpravidh, RW; Masaratana, P; Panachan, J; Panichkul, N; Srisomsap, C; Svasti, J; Weeraphan, C | 1 |
| Shao, R; Shen, H; Shen, X; Wang, B; Xia, Y; Zhang, J; Zhang, T; Zheng, P; Zou, P | 1 |
| Beuschel, RT; Bui, SN; Cannon, B; Chhina, MK; Ellis, E; Grant, GM; Lemma, M; Liberti, EM; Nathan, SD; Rodriguez, LR | 1 |
| Chen, XY; Fu, TM; Jing, J; Meng, ZP; Su, WQ; Wei, TX; Wu, XX; Zhu, HX | 1 |
| Asghar, S; Chen, Z; Hu, Z; Ping, Q; Shao, F; Xiao, Y; Yu, F; Zhang, S | 2 |
| Chen, Y; Ding, L; Du, Z; Liu, B; Liu, J; Wu, X; Xiao, H; Zhang, B; Zhang, H; Zhang, T | 1 |
| Ke, S; Lan, Z; Li, S; Liu, L; Zhang, Y; Zhu, W | 1 |
| Castro, B; Comino-Sanz, IM; López-Franco, MD; Pancorbo-Hidalgo, PL | 1 |
| Abdallah, FR; Atteia, HH; Elswefy, SE; Hasan, RA; Wahba, AS | 1 |
| de Souza Carvalho-Wodarz, C; Lababidi, N; Lehr, CM; Montefusco-Pereira, CV; Schneider, M | 1 |
| Aguiar, GPS; Alves, BO; Apel, MA; Danielli, LJ; Dos Santos, AE; Müller, LG; Oliveira, JV; Paulazzi, AR; Pedroso, J; Petry, F; Siebel, AM; Soares, KD; Zilli, GAL | 1 |
| Hussein, RM; Kandeil, MA; Khallaf, RA; Mohammed, NA | 1 |
| Anadón, A; Ares, I; Lopez-Torres, B; Martínez, M; Martinez, MA; Martínez-Larrañaga, MR; Wang, X; Xu, X; Yang, Y | 1 |
| Chen, H; Liu, B; Tang, M | 1 |
| Agarwal, R; Shukla, GS | 1 |
| Accardi, M; Baietti, MG; Fadin, M; Fratter, A; Nicoletti, MC; Pellizzato, M | 1 |
4 review(s) available for acetylcysteine and curcumin
| Article | Year |
|---|---|
Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Clinical Trials as Topic; Curcumin; Humans; Neoplasms; Pentacyclic Triterpenes; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Triterpenes; Ubiquitin | 2008 |
Biofilm and Helicobacter pylori: from environment to human host.
Topics: Acetylcysteine; Anti-Bacterial Agents; Biofilms; Curcumin; Environment; Environmental Microbiology; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Water Microbiology | 2014 |
The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta-analysis.
Topics: Acetylcysteine; Amoxicillin; Anti-Bacterial Agents; Antioxidants; Clarithromycin; Curcumin; Helicobacter pylori; Humans; Vaccinium macrocarpon; Vitamins | 2018 |
Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage.
Topics: Acetylcysteine; Animals; Antidotes; Antioxidants; Ascorbic Acid; Curcumin; Glutathione; Mammals; Neonicotinoids; Oxidative Stress; Reactive Oxygen Species; Resveratrol | 2022 |
3 trial(s) available for acetylcysteine and curcumin
| Article | Year |
|---|---|
A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetylcysteine; Adult; Aged; Curcumin; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacter pylori; Humans; Lactoferrin; Male; Middle Aged; Pantoprazole; Treatment Failure | 2007 |
Differentially expressed plasma proteins of β-thalassemia/hemoglobin E patients in response to curcuminoids/vitamin E antioxidant cocktails.
Topics: Acetylcysteine; Adult; beta-Thalassemia; Blood Proteins; Curcumin; Deferiprone; Drug Therapy, Combination; Female; Free Radical Scavengers; Gene Expression Regulation; Hemoglobin E; Humans; Male; Vitamin E | 2019 |
Antioxidant dressing therapy versus standard wound care in chronic wounds (the REOX study): study protocol for a randomized controlled trial.
Topics: Acetylcysteine; Antioxidants; Bandages; Curcumin; Galactans; Galactose; Humans; Mannans; Multicenter Studies as Topic; Plant Gums; Randomized Controlled Trials as Topic; Single-Blind Method; Spain; Wound Healing; Wounds and Injuries | 2020 |
90 other study(ies) available for acetylcysteine and curcumin
| Article | Year |
|---|---|
3,3'-OH curcumin causes apoptosis in HepG2 cells through ROS-mediated pathway.
Topics: Antineoplastic Agents; Apoptosis; Curcumin; Hep G2 Cells; Humans; Hydroxyl Radical; Liver; Liver Neoplasms; Reactive Oxygen Species | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Inability of several mutagen-blocking agents to inhibit 1,2-dimethylhydrazine-induced DNA-damaging activity in colonic epithelium.
Topics: 1,2-Dimethylhydrazine; Acetylcysteine; Animals; Carcinogens; Cell Nucleus; Colon; Coumaric Acids; Curcumin; Dimethylhydrazines; Ellagic Acid; Epithelium; Female; Glutathione; Methylhydrazines; Mice; Mice, Inbred C57BL; Mutation; Quercetin | 1983 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
Topics: Acetylcysteine; Arsenites; Blotting, Northern; Blotting, Western; Colorectal Neoplasms; Curcumin; Cyclooxygenase Inhibitors; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; HSP70 Heat-Shock Proteins; Humans; Indomethacin; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
Potential role of antioxidants during ethanol-induced changes in the fatty acid composition and arachidonic acid metabolites in male Wistar rats.
Topics: Acetylcysteine; Alprostadil; Animals; Antioxidants; Arachidonic Acid; Body Weight; Brain; Central Nervous System Depressants; Curcumin; Dinoprost; Dinoprostone; Enzyme Inhibitors; Ethanol; Fatty Acids; Kidney; Liver; Male; Phospholipids; Prostaglandin D2; Rats; Rats, Wistar | 2001 |
Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers.
Topics: Acetylcysteine; Animals; Astrocytes; Caffeic Acids; Cell Survival; Cells, Cultured; Curcumin; Drug Interactions; Enzyme Activation; Enzyme Induction; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Phenylethyl Alcohol; Rats; Up-Regulation | 2002 |
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.
Topics: Acetylcysteine; Base Sequence; Cell Division; Curcumin; Cyclin D1; Cyclin D2; Cyclin D3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; DNA Primers; Down-Regulation; Humans; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins; Retinoblastoma Protein; RNA, Messenger; Tumor Cells, Cultured | 2002 |
Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes.
Topics: Acetylcysteine; ADAM Proteins; ADAMTS4 Protein; Animals; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Collagenases; Curcumin; Enzyme Inhibitors; Humans; Interleukin-17; JNK Mitogen-Activated Protein Kinases; Masoprocol; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Metalloendopeptidases; Mitogen-Activated Protein Kinases; NF-kappaB-Inducing Kinase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Procollagen N-Endopeptidase; Protein Serine-Threonine Kinases; Signal Transduction; Transcription Factor AP-1 | 2004 |
Blocking NF-kappaB activation may be an effective strategy in the fever therapy.
Topics: Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antibodies, Monoclonal; Curcumin; Cytokines; Fever; Humans; Injections, Intravenous; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Male; NF-kappa B; Pyridines; Pyrrolidines; Rabbits; Thiocarbamates; Thiones; Time Factors; Tumor Necrosis Factor-alpha | 2003 |
Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.
Topics: Acetylcysteine; Adult; Aged; Anti-Infective Agents; Antioxidants; Arteriosclerosis; Cells, Cultured; Curcumin; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Flavonoids; Foam Cells; Gene Expression Regulation; Glucose; Glycation End Products, Advanced; Humans; Hyperglycemia; Macrophages; Male; MAP Kinase Signaling System; Mesylates; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Processing, Post-Translational; Pyrroles; Receptors, LDL; RNA, Messenger; Signal Transduction; Sulfones; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2004 |
Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Benzoates; Bridged-Ring Compounds; Caspases; Curcumin; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Glucosides; Humans; Jurkat Cells; Lymphocytes; Membrane Potentials; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Monoterpenes; Oxidation-Reduction; Paeonia; Phosphorylation; Reactive Oxygen Species | 2004 |
Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Cell Proliferation; Cell Survival; Curcumin; Glutathione; HL-60 Cells; Humans; Hydrogen Peroxide; Indicators and Reagents; Leukemia; Lipid Peroxidation; Malondialdehyde; Oxidants; Reactive Oxygen Species | 2005 |
Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants.
Topics: Acetylcysteine; Anti-Inflammatory Agents; Cells, Cultured; Curcumin; Diet, Mediterranean; Electrophoretic Mobility Shift Assay; Endothelial Cells; Humans; Interleukin-1; Interleukin-6; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Plant Extracts; Quercetin; Sesquiterpenes; STAT Transcription Factors; Transcription Factor AP-1 | 2005 |
Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Ceramides; Colonic Neoplasms; Curcumin; Enzyme Activation; Fatty Acids, Monounsaturated; Humans; Immunosuppressive Agents; JNK Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured | 2006 |
Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Curcumin; Drug Synergism; Gene Expression Regulation; Humans; Membrane Glycoproteins; Promoter Regions, Genetic; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; RNA, Messenger; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor CHOP; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Base Sequence; Biological Products; Blotting, Western; Cell Line, Tumor; Curcumin; Cysteine; DNA Modification Methylases; DNA Primers; DNA Repair Enzymes; Dose-Response Relationship, Drug; Fenretinide; Glutathione; Glutathione S-Transferase pi; Humans; Lymphocytes; Prodrugs; Pyrazines; RNA, Messenger; Silymarin; Thiones; Thiophenes; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins | 2007 |
Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells.
Topics: Acetylation; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Drug Synergism; Histones; HL-60 Cells; Humans; Hydroxamic Acids; Indicators and Reagents; L-Lactate Dehydrogenase; Leukemia, Promyelocytic, Acute; Protein Synthesis Inhibitors; Reactive Oxygen Species | 2006 |
Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells.
Topics: Acetylcysteine; Antioxidants; Catechin; Colorectal Neoplasms; Culture Media; Curcumin; Gallic Acid; Genes, Reporter; HT29 Cells; Humans; Hydrogen Peroxide; Isothiocyanates; Luciferases; Matrix Metalloproteinase 7; RNA, Messenger; Transcription Factor AP-1 | 2007 |
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Curcumin; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Fluorescence; Molecular Structure; Reactive Oxygen Species; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 2007 |
Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Bilirubin; Cicatrix; Collagen; Curcumin; Dermis; Dose-Response Relationship, Drug; Fibroblasts; Gels; Glutathione; Heme Oxygenase (Decyclizing); Humans; Reactive Oxygen Species; Wound Healing | 2009 |
Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells.
Topics: Acetophenones; Acetylcysteine; Butadienes; Cells, Cultured; Curcumin; Cytoplasm; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase Kinases; Myocytes, Smooth Muscle; NADPH Oxidases; NF-kappa B; Nitriles; Onium Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; RNA, Small Interfering; Sesquiterpenes; Sesquiterpenes, Guaiane; Smoking; Trachea; Transcription Factor AP-1; Transcriptional Activation | 2009 |
Curcumin mediates time and concentration dependent regulation of redox homeostasis leading to cytotoxicity in macrophage cells.
Topics: Acetylcysteine; Animals; Antioxidants; Biological Transport; Cell Line; Cell Survival; Curcumin; Dose-Response Relationship, Drug; Gamma Rays; Gene Expression Regulation; Glutathione; Homeostasis; Macrophages; Mice; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sulfhydryl Compounds; Time Factors | 2009 |
Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities.
Topics: Acetylcysteine; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line, Tumor; Chromatography, High Pressure Liquid; Curcumin; Flow Cytometry; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Pyrazoles; Structure-Activity Relationship | 2009 |
Role of HSP27 and reduced glutathione in modulating malathion-induced apoptosis of human peripheral blood mononuclear cells: ameliorating effect of N-acetylcysteine and curcumin.
Topics: Acetylcysteine; Apoptosis; Curcumin; Free Radical Scavengers; Glutathione; HSP27 Heat-Shock Proteins; Humans; Leukocytes, Mononuclear; Malathion; Oxidative Stress; Pesticides; Protective Agents; Toxicity Tests | 2009 |
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Cell Line, Transformed; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Gene Expression Regulation; Herbicides; Hydrogen Peroxide; Mesencephalon; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Paraquat; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Tyrosine; Vitamin E | 2009 |
Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Biomarkers; Catalase; Curcumin; Drug Synergism; Glutathione Peroxidase; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serologic Tests | 2010 |
Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells.
Topics: Acetylcysteine; Animals; Cells, Cultured; Curcumin; Cyclooxygenase 2; Free Radical Scavengers; Gene Expression Regulation; Isoquinolines; Leupeptins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Piperidines; Poly Adenosine Diphosphate Ribose; Pyrrolidines; Rabbits; Stress, Mechanical; Structure-Activity Relationship; Synovial Membrane; Thiocarbamates | 2010 |
N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells.
Topics: Acetylcysteine; Adenocarcinoma; Cell Line, Tumor; Cell Shape; Cell Survival; Curcumin; Down-Regulation; Humans; Lung Neoplasms; Reactive Oxygen Species; Sp1 Transcription Factor; Telomerase | 2010 |
Curcuminoids activate p38 MAP kinases and promote UVB-dependent signalling in keratinocytes.
Topics: Acetylcysteine; Cell Division; Cell Proliferation; Cells, Cultured; Curcumin; Cyclin-Dependent Kinase Inhibitor p21; Glutathione; Humans; Imidazoles; Interphase; Keratinocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Tumor Suppressor Protein p53; Ultraviolet Rays | 2010 |
Astrocyte-derived glutathione attenuates hemin-induced apoptosis in cerebral microvascular cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Astrocytes; Brain; Caspase 3; Cells, Cultured; Curcumin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Hemin; Humans; L-Lactate Dehydrogenase; Mice; Microvessels; Neuroprotective Agents; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Time Factors | 2010 |
Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Line; Cholinergic Agonists; Curcumin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Free Radical Scavengers; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mouth Mucosa; Mouth Neoplasms; Protein Kinase C; Staurosporine; Time Factors; Transcription Factor AP-1 | 2010 |
Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention.
Topics: Acetylcysteine; Adult; Antioxidants; Cells, Cultured; Cellular Senescence; Curcuma; Curcumin; DNA Damage; Enzyme Inhibitors; Female; Fibroblasts; Glutathione Disulfide; Glutathione Transferase; Heme Oxygenase-1; Humans; Oxidation-Reduction; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Plant Extracts; Reactive Oxygen Species; Signal Transduction; Skin; Spices | 2011 |
Ameliorating effect of N-acetylcysteine and curcumin on pesticide-induced oxidative DNA damage in human peripheral blood mononuclear cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Antioxidants; Curcumin; Deoxyguanosine; DNA Damage; Endosulfan; Environmental Pollutants; Humans; Leukocytes, Mononuclear; Lipid Peroxidation; Malathion; Malondialdehyde; Oxidative Stress; Pesticides; Phosphamidon | 2011 |
Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
Topics: Acetylcysteine; Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Benzodioxoles; Brain; Catechin; Cerebral Cortex; Cognition; Curcumin; Dietary Supplements; Folic Acid; Hippocampus; Humans; Immunoblotting; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Piperidines; Polyunsaturated Alkamides; Thioctic Acid; Vitamin B Complex; Vitamins | 2010 |
Prevention of sodium valproate-induced hepatotoxicity by curcumin, rosiglitazone and N-acetylcysteine in rats.
Topics: Acetylcysteine; Animals; Anticonvulsants; Body Weight; Chemical and Drug Induced Liver Injury; Convulsants; Curcumin; Eating; Fatty Liver; Free Radical Scavengers; Hypoglycemic Agents; Liver; Liver Function Tests; Male; Mice; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rosiglitazone; Seizures; Thiazolidinediones; Valproic Acid | 2010 |
Antioxidative effects of N-acetylcysteine, lipoic acid, taurine, and curcumin in the muscle of Cyprinus carpio L. exposed to cadmium.
Topics: Acetylcysteine; Animals; Antioxidants; Cadmium; Carps; Catalase; Curcumin; Enzyme Inhibitors; Free Radical Scavengers; Glutathione Disulfide; Glutathione Peroxidase; Lipid Peroxidation; Muscle, Skeletal; Oxidative Stress; Superoxide Dismutase; Taurine; Thioctic Acid | 2011 |
Activation and induction of cytosolic phospholipase A2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells.
Topics: Acetophenones; Acetylation; Acetylcysteine; Cell Line; Curcumin; Dinoprostone; E1A-Associated p300 Protein; Enzyme Inhibitors; Free Radical Scavengers; Histones; Humans; Membrane Glycoproteins; Metabolic Networks and Pathways; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Onium Compounds; Phospholipases A2; Phosphorylation; Sesquiterpenes; Sesquiterpenes, Guaiane; Trachea; Tumor Necrosis Factor-alpha | 2011 |
Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Calcium; Carcinoma; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Curcumin; Cytosol; DNA Damage; Enzyme Activation; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Models, Biological; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Reactive Oxygen Species; Signal Transduction | 2011 |
Curcumin nanodisk-induced apoptosis in mantle cell lymphoma.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Cell Cycle; Cell Line, Tumor; Curcumin; Cyclin D1; Dose-Response Relationship, Drug; Drug Delivery Systems; Flow Cytometry; G1 Phase; Humans; Lymphoma, Mantle-Cell; Nanostructures; Nanotechnology; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2011 |
Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Curcumin; gamma-Glutamyltransferase; Glutathione; Liver Cirrhosis; Male; Malondialdehyde; Matrix Metalloproteinase 13; Rats; Rats, Wistar; Thioctic Acid; Transforming Growth Factor alpha | 2012 |
Comparison of the protective effects of antioxidant compounds in the liver and kidney of Cd- and Cr-exposed common carp.
Topics: Acetylcysteine; Animals; Antioxidants; Cadmium; Carps; Catalase; Chromium; Curcumin; Glutathione; Kidney; Lipid Peroxidation; Liver; Oxidative Stress; Superoxide Dismutase; Taurine; Thioctic Acid; Water Pollutants, Chemical | 2014 |
Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model.
Topics: Acetylcysteine; Antitubercular Agents; Cell Cycle; Cell Survival; Chemical and Drug Induced Liver Injury; Curcumin; Hep G2 Cells; Humans; Isoniazid; Membrane Potential, Mitochondrial; Protective Agents; Pyrazinamide; Silymarin | 2012 |
The effect of the NF-kappa B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Curcumin; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Muscle Development; Myoblasts; NF-kappa B; Phosphorylation; Rhabdomyosarcoma; Signal Transduction | 2012 |
Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells.
Topics: Acetylcysteine; Acridine Orange; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Cadaverine; Carcinoma, Squamous Cell; Cell Proliferation; Curcumin; Flow Cytometry; Humans; Microtubule-Associated Proteins; Mouth Neoplasms; Reactive Oxygen Species; Staining and Labeling; Tumor Cells, Cultured; Vacuoles | 2012 |
Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine.
Topics: Acetylcysteine; Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Camellia sinensis; Curcumin; Cyclophosphamide; Dietary Supplements; Disease Models, Animal; Inflammation Mediators; Lipid Peroxidation; Lung; Male; Plant Extracts; Plant Leaves; Protective Agents; Pulmonary Fibrosis; Rats; Rats, Wistar; Tea | 2012 |
The upregulation of transglutaminase-2 by cyclosporin a in human gingival fibroblasts is augmented by oxidative stress.
Topics: Acetylcysteine; Adult; Antioxidants; Catechin; Cell Culture Techniques; Cells, Cultured; Chromones; Curcumin; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Free Radical Scavengers; Gingiva; GTP-Binding Proteins; Humans; Imidazoles; Immunosuppressive Agents; Male; Morpholines; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protease Inhibitors; Protein Glutamine gamma Glutamyltransferase 2; Pyridines; Reactive Oxygen Species; Transglutaminases; Up-Regulation | 2013 |
High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation.
Topics: Acetylcysteine; Androstadienes; Chromones; Curcumin; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Glucose; Humans; Joint Capsule; Morpholines; NADPH Oxidases; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1; Vascular Endothelial Growth Factor A; Wortmannin | 2013 |
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Curcumin; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Nerve Sheath Neoplasms; Neurofibromatosis 1; Neurofibromin 1; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Schwann Cells; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand | 2013 |
Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Curcumin; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Diarylheptanoids; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Nitrogen Oxides; Reactive Oxygen Species; Retinoblastoma Protein; Signal Transduction; Tumor Suppressor Protein p53 | 2013 |
Curcumin sensitizes lung adenocarcinoma cells to apoptosis via intracellular redox status mediated pathway.
Topics: Acetylcysteine; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Buthionine Sulfoximine; Caspase 3; Cell Line, Tumor; Curcumin; Drug Screening Assays, Antitumor; Enzyme Activation; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Humans; Lipid Peroxidation; Lung Neoplasms; MAP Kinase Signaling System; Oxidants; Oxidation-Reduction; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Messenger; RNA, Neoplasm; Superoxides | 2012 |
MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line, Tumor; Cell Nucleus; Curcumin; Enzyme Activation; Forkhead Box Protein O3; Forkhead Transcription Factors; Hepatocyte Growth Factor; JNK Mitogen-Activated Protein Kinases; Melanoma; Melanoma, Experimental; Mice; Protein Transport; Proto-Oncogene Proteins; Reactive Oxygen Species | 2013 |
Impact of antioxidants on the ability of phenolic phytochemicals to kill HCT116 colon cancer cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Ascorbic Acid; Catechin; Cell Line, Tumor; Colonic Neoplasms; Curcumin; DNA Damage; Drug Interactions; Gene Expression; HCT116 Cells; Heme Oxygenase-1; HT29 Cells; Humans; Iron Chelating Agents | 2014 |
Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: effect of N-acetylcysteine and curcumin.
Topics: Acetylcysteine; Adult; Anti-Inflammatory Agents; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Colon; Crohn Disease; Curcumin; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Intestinal Mucosa; Matrix Metalloproteinase 3; Middle Aged; Myofibroblasts; Oxidation-Reduction; Oxidative Stress; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha; Up-Regulation; Young Adult | 2014 |
Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells.
Topics: Acetylcysteine; Adipose Tissue; Animals; Antioxidants; Apoptosis; Bilirubin; Biliverdine; Cells, Cultured; Curcumin; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydrogen Peroxide; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Organometallic Compounds; RNA, Messenger; Up-Regulation | 2014 |
NADPH Oxidase 4 Mediates TGFβ1-induced CCN2 in Gingival Fibroblasts.
Topics: Acetylcysteine; Cell Culture Techniques; Cells, Cultured; Connective Tissue Growth Factor; Curcumin; Enzyme Inhibitors; Fibroblasts; Free Radical Scavengers; Gene Silencing; Gingiva; Gingival Overgrowth; Humans; MAP Kinase Signaling System; NADPH Oxidase 4; NADPH Oxidases; Naphthoquinones; Oxidation-Reduction; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Smad3 Protein; src-Family Kinases; Superoxides; Transforming Growth Factor beta1 | 2015 |
Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Curcumin; Cycloheximide; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Immunohistochemistry; Male; Mice; Mice, SCID; Microtubule-Associated Proteins; Prostatic Neoplasms; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Transcription Factor CHOP; Transplantation, Heterologous; Vacuoles | 2015 |
Effects of local curcumin on oxidative stress and total antioxidant capacity in vivo study.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Curcuma; Curcumin; Cytoprotection; Hydrogen Peroxide; Lipid Peroxidation; Liver; Oxidants; Oxidative Stress; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rhizome; Time Factors | 2014 |
Development and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healing.
Topics: Acetylcysteine; Animals; Antioxidants; Bandages; Curcumin; Cytokines; Fibroblasts; Galactans; Galactose; Humans; Inflammation; Irritants; Mannans; Materials Testing; Oxidative Stress; Plant Gums; Reactive Oxygen Species; Sus scrofa; Wound Healing | 2015 |
Differential protection of pre- versus post-treatment with curcumin, Trolox, and N-acetylcysteine against acrylonitrile-induced cytotoxicity in primary rat astrocytes.
Topics: Acetylcysteine; Acrylonitrile; Animals; Antioxidants; Astrocytes; Cell Survival; Cells, Cultured; Chromans; Curcumin; Cytotoxins; Glutathione; Lipid Peroxidation; Membrane Potential, Mitochondrial; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Rats; Reactive Oxygen Species | 2015 |
Effects of bleomycin and antioxidants on the fatty acid profile of testicular cancer cell membranes.
Topics: Acetylcysteine; Bleomycin; Cell Line, Tumor; Curcumin; Fatty Acids; Free Radical Scavengers; Humans; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Testicular Neoplasms | 2016 |
A comparative study on the efficiency of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan surface modified nanostructured lipid carrier for ophthalmic delivery of curcumin.
Topics: Acetylcysteine; Administration, Ophthalmic; Animals; Chitin; Chitosan; Cornea; Curcumin; Drug Carriers; Drug Liberation; Female; Kinetics; Lipids; Male; Nanostructures; Oligosaccharides; Particle Size; Permeability; Rabbits | 2016 |
Reactive Oxygen Species Limit the Ability of Bone Marrow Stromal Cells to Support Hematopoietic Reconstitution in Aging Mice.
Topics: Acetylcysteine; Aging; Animals; Apoptosis; Bone Marrow Cells; Cellular Senescence; Colony-Forming Units Assay; Curcumin; Gene Expression Regulation; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Mesenchymal Stem Cells; Mice, Inbred C57BL; Myeloid Cells; Reactive Oxygen Species; Stress, Physiological; Stromal Cells | 2016 |
Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Cornea; Curcumin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Female; Humans; Lipids; Male; Nanostructures; Ophthalmic Solutions; Particle Size; Rabbits; Surface Properties | 2016 |
Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species.
Topics: Acetylcysteine; Adult; Antineoplastic Agents; Cell Proliferation; Cell Survival; Curcumin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Free Radical Scavengers; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases; Neoplastic Stem Cells; Oxidative Stress; Reactive Oxygen Species; STAT3 Transcription Factor; Survivin; Tumor Cells, Cultured | 2017 |
Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress.
Topics: Acetylcysteine; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma; Membrane Potential, Mitochondrial; Oxidative Stress; Time Factors; Up-Regulation | 2017 |
N-acetyl-L-cysteine functionalized nanostructured lipid carrier for improving oral bioavailability of curcumin: preparation, in vitro and in vivo evaluations.
Topics: Acetylcysteine; Administration, Oral; Animals; Area Under Curve; Curcumin; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Intestinal Mucosa; Male; Nanoparticles; Particle Size; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Surface Properties | 2017 |
Comparative analysis of the protective effects of curcumin and N-acetyl cysteine against paracetamol-induced hepatic, renal, and testicular toxicity in Wistar rats.
Topics: Acetylcysteine; Animals; Antioxidants; Curcumin; Kidney; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats, Wistar; Sperm Count; Sperm Motility; Testis | 2018 |
A new antioxidant formulation reduces the apoptotic and damaging effect of cigarette smoke extract on human bronchial epithelial cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Bronchi; Cell Line; Curcumin; Cytokines; Drug Compounding; Epithelial Cells; Heme Oxygenase-1; Humans; NF-E2-Related Factor 2; Nicotiana; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; Smoke | 2017 |
The use of an antioxidant dressing on hard-to-heal wounds: a multicentre, prospective case series.
Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Antioxidants; Bandages; Curcumin; Female; Galactans; Galactose; Humans; Kaplan-Meier Estimate; Male; Mannans; Middle Aged; Plant Gums; Prospective Studies; Wound Healing; Wounds and Injuries | 2017 |
The effect of curcumin on cell adhesion of human esophageal cancer cell.
Topics: Acetylcysteine; Apoptosis; Cell Adhesion; Cell Line, Tumor; Curcumin; Esophageal Neoplasms; Fulvestrant; Glutathione; Humans; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor; Superoxide Dismutase | 2018 |
Autophagy is a major mechanism for the dual effects of curcumin on renal cell carcinoma cells.
Topics: Acetylcysteine; AMP-Activated Protein Kinases; Antineoplastic Agents; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Curcumin; Endoplasmic Reticulum Stress; Humans; Kidney Neoplasms; Oxidative Stress; Phenylbutyrates; Pyrazoles; Pyrimidines; Signal Transduction | 2018 |
N-Acetyl Cysteine and Curcumin in Pediatric Acute-Onset Neuropsychiatric Syndrome.
Topics: Acetylcysteine; Acute Disease; Child, Preschool; Curcumin; Female; Humans; Neurodevelopmental Disorders; Obsessive-Compulsive Disorder; Syndrome; Treatment Outcome | 2018 |
T59, a New Compound Reconstructed from Curcumin, Induces Cell Apoptosis through Reactive Oxygen Species Activation in Human Lung Cancer Cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Potentials; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway.
Topics: Acetylcysteine; Anti-Inflammatory Agents; Antioxidants; Cell Line; Chromones; Curcumin; Diabetic Retinopathy; Drug Synergism; Epithelial Cells; Gene Expression Regulation; Glucose; Humans; Interleukin-1beta; Interleukin-6; Models, Biological; Morpholines; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Retinal Pigment Epithelium; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2019 |
Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Death; Cell Proliferation; Cell Survival; Cisplatin; Colonic Neoplasms; Curcumin; DNA Damage; Drug Synergism; HCT116 Cells; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Piperazines; Reactive Oxygen Species; Surface Plasmon Resonance; Thioredoxin Reductase 1; Xenograft Model Antitumor Assays | 2019 |
Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Curcumin; Epithelial Cells; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Oxidative Stress; Polymerase Chain Reaction; Reactive Oxygen Species | 2019 |
[Effect of N-acetyl-L-cysteine on bioavailability and brain distribution of curcumin by nasal delivery].
Topics: Acetylcysteine; Administration, Intranasal; Animals; Biological Availability; Brain; Brain Chemistry; Chromatography, Liquid; Curcumin; Rats; Tandem Mass Spectrometry; Tissue Distribution | 2019 |
BSA Nanoparticles Modified with
Topics: Acetylcysteine; Animals; Caco-2 Cells; Cattle; Curcumin; Drug Carriers; Drug Delivery Systems; Drug Stability; Gastrointestinal Tract; Humans; Nanoparticles; Particle Size; Serum Albumin, Bovine | 2019 |
Topics: Acetylcysteine; Caco-2 Cells; Chitosan; Curcumin; Cysteine; Drug Carriers; Drug Delivery Systems; Humans; Hydrophobic and Hydrophilic Interactions; Lactoglobulins; Molecular Docking Simulation; Nanoparticles; Particle Size; Peptides | 2019 |
Curcumin protects murine lung mesenchymal stem cells from H
Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Curcumin; Cytoprotection; Heme Oxygenase-1; Hydrogen Peroxide; Intracellular Space; Lung; Male; Membrane Potential, Mitochondrial; Mesenchymal Stem Cells; Mice, Inbred C57BL; Mitochondria; NF-E2-Related Factor 2; Protective Agents; Proto-Oncogene Proteins c-akt; Signal Transduction | 2020 |
The enhancement of N-acetylcysteine on intestinal absorption and oral bioavailability of hydrophobic curcumin.
Topics: Acetylcysteine; Administration, Oral; Animals; Biological Availability; Curcumin; Drug Carriers; Intestinal Absorption; Nanoparticles; Rats | 2020 |
Antifibrotic effect of curcumin, N-acetyl cysteine and propolis extract against bisphenol A-induced hepatotoxicity in rats: Prophylaxis versus co-treatment.
Topics: Acetylcysteine; Animals; Apoptosis; Benzhydryl Compounds; Chemical and Drug Induced Liver Injury; Curcumin; Drug Therapy, Combination; Inflammation; Interleukins; Liver; Liver Cirrhosis; Male; Phenols; Propolis; Rats; Rats, Wistar | 2020 |
Spray-dried multidrug particles for pulmonary co-delivery of antibiotics with N-acetylcysteine and curcumin-loaded PLGA-nanoparticles.
Topics: Acetylcysteine; Administration, Inhalation; Anti-Bacterial Agents; Anti-Inflammatory Agents; Azithromycin; Ciprofloxacin; Curcumin; Cytokines; Drug Carriers; Drug Combinations; Drug Compounding; Expectorants; Freeze Drying; Humans; Inflammation Mediators; Macrophages; Microbial Viability; Mucus; Nanoparticles; Permeability; Polylactic Acid-Polyglycolic Acid Copolymer; Pseudomonas aeruginosa; Pseudomonas Infections; THP-1 Cells; Tobramycin | 2020 |
Curcumin and n-acetylcysteine cocrystal produced with supercritical solvent: characterization, solubility, and preclinical evaluation of antinociceptive and anti-inflammatory activities.
Topics: Acetylcysteine; Analgesics; Animals; Anti-Inflammatory Agents; Crystallization; Curcumin; Mice; Solubility; Solvents | 2022 |
Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity
Topics: Acetaminophen; Acetylcysteine; Animals; Curcumin; Liposomes; Nanoparticles; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2022 |
Activation of the ROS/CncC Signaling Pathway Regulates Cytochrome P450
Topics: Acetylcysteine; Animals; Antioxidants; Bicyclic Monoterpenes; Curcumin; Cytochrome P-450 Enzyme System; Hydrogen Peroxide; Pesticides; Pheromones; Reactive Oxygen Species; Signal Transduction; Terpenes; Transcription Factors | 2022 |
Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Brain; Curcuma; Glutathione; Ketones; Liver; Male; Maleates; Plant Extracts; Rats; Rats, Inbred Strains; Vitamin E | 1999 |
Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies.
Topics: Acetylcysteine; Curcuma; Dysmenorrhea; Dyspareunia; Endometriosis; Humans; Inflammation; Quercetin | 2020 |