acetylcysteine and cocaine

acetylcysteine has been researched along with cocaine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.86)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (31.43)	29.6817
2010's	20 (57.14)	24.3611
2020's	3 (8.57)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Norn, MS; Opauszki, A	1
Alvarez, AM; Andrés, D; Cascales, M; Díez-Fernández, C; Zaragoza, A	2
Abdel-Rahman, MS; Labib, R; Turkall, R	1
Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Tang, XC; Toda, S	1
Beebe, SJ; Hargrave, BY; Lattanzio, FA; Tiangco, DA	1
Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Toda, S	1
Beebe, S; Hargrave, BY; Kerry, J; Lattanzio, FA; Osgood, C; Tiangco, D	1
Coleman, A; Colman, R	1
Achat-Mendes, C; Anderson, KL; Itzhak, Y	1
Abdulhameed, O; Baker, DA; Grier, MD; Hearing, M; Kau, KS; Lobner, D; Madayag, A; Mantsch, JR	1
Do, PH; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE	1
Belin, D; Everitt, BJ; Murray, JE	1
Kalivas, BC; Kalivas, PW; Kolokithas, R; Kupchik, YM; Moussawi, K; Ogburn, KB; Tang, XC; Wang, X	1
Bauzo, RM; Howell, LL; Kimmel, HL	1
Kalivas, P; Post, RM	1
Badisa, RB; Fitch-Pye, CA; Goodman, CB	1
DeCaprio, AP; Schneider, KJ	1
Balleine, BW; Chieng, BC; Corbit, LH	1
Gipson, CD; Kalivas, PW; Knackstedt, LA; Reissner, KJ; Scofield, MD; Tran, PK	1
Białko, M; Filip, M; Frankowska, M; Jastrzębska, J; Nowak, E; Przegaliński, E	1
Allen, JR; Badisa, RB; Davidson, MW; Fitch-Pye, CA; Goodman, CB; Haughbrook, RD; Kumar, SS; Mazzio, E	1
Belin, D; Belin-Rauscent, A; Ducret, E; Dugast, E; Everitt, BJ; Fouyssac, M; Houeto, JL; Lacoste, J; Murray, JE; Puaud, M	1
Antonilli, L; Badiani, A; Grassi, MC; Graziani, M; Saso, L; Togna, AR	1
Atlas, D; Filip, M; Frankowska, M; Jastrzębska, J	1
Bell, RL; Breier, A; Chambers, RA; Engleman, EA; Hulvershorn, LA; Rao, KN; Sentir, AM	1
Alcorn, JL; Hays, LR; Levi Bolin, B; Lile, JA; Rayapati, AO; Rush, CR; Stoops, WW	1
Belin, D; Everitt, BJ; Fouyssac, M; Hodebourg, R; Murray, JE; Puaud, M	1
Bergman, J; Doyle, RJ; Kangas, BD; Kaufman, MJ; Kohut, SJ	1
Boendermaker, WJ; Goudriaan, AE; Kaag, AM; Schulte, MHJ; van den Brink, W; Wiers, RW	1
Garcia-Keller, C; Gass, J; Kalivas, PW; Melton, S; Monforton, C; Smiley, C	1
Campo, L; Frigerio, G; Fustinoni, S; Mercadante, R; Mielżyńska-Švach, D; Pavanello, S	1
Engeli, EJE; Esposito, F; Herdener, M; Hock, A; Hulka, LM; Kirschner, M; Ponticorvo, S; Preller, KH; Quednow, BB; Russo, AG; Seifritz, E; Zoelch, N	1

Reviews

2 review(s) available for acetylcysteine and cocaine

Article	Year
Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation. The British journal of psychiatry : the journal of mental science, 2013, Volume: 202, Issue:3 Topics: Acetylcysteine; Age of Onset; Animals; Basal Ganglia; Behavior, Addictive; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disorders; Comorbidity; Diagnosis, Dual (Psychiatry); Disease Models, Animal; Disease Progression; Dopamine Uptake Inhibitors; Epigenomics; Free Radical Scavengers; Humans; Recurrence; Stress, Psychological	2013
Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress. Oxidative medicine and cellular longevity, 2016, Volume: 2016 Topics: Acetylcysteine; Animals; Antioxidants; Cardiovascular Diseases; Catecholamines; Cattle; Cocaine; Humans; Liver; Male; Mice; Mitochondria; Myocytes, Smooth Muscle; NADPH Oxidases; Nitrogen Oxides; Oxidative Stress; Rats; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Xanthine Oxidase	2016

Article

Year

Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation.

The British journal of psychiatry : the journal of mental science, 2013, Volume: 202, Issue:3

Topics: Acetylcysteine; Age of Onset; Animals; Basal Ganglia; Behavior, Addictive; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disorders; Comorbidity; Diagnosis, Dual (Psychiatry); Disease Models, Animal; Disease Progression; Dopamine Uptake Inhibitors; Epigenomics; Free Radical Scavengers; Humans; Recurrence; Stress, Psychological

2013

Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress.

Oxidative medicine and cellular longevity, 2016, Volume: 2016

Topics: Acetylcysteine; Animals; Antioxidants; Cardiovascular Diseases; Catecholamines; Cattle; Cocaine; Humans; Liver; Male; Mice; Mitochondria; Myocytes, Smooth Muscle; NADPH Oxidases; Nitrogen Oxides; Oxidative Stress; Rats; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Xanthine Oxidase

2016

Trials

2 trial(s) available for acetylcysteine and cocaine

Article	Year
The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users. Psychiatry research. Neuroimaging, 2019, 05-30, Volume: 287 Topics: Acetylcysteine; Brain; Cocaine; Cocaine-Related Disorders; Cognition; Cues; Double-Blind Method; Humans; Male; Memory, Short-Term	2019
Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and NeuroImage. Clinical, 2023, Volume: 39 Topics: Acetylcysteine; Animals; Cocaine; Glutamic Acid; Humans; Magnetic Resonance Imaging; Proton Magnetic Resonance Spectroscopy	2023

Other Studies

31 other study(ies) available for acetylcysteine and cocaine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Effects of ophthalmic vehicles on the stability of the precorneal film. Acta ophthalmologica, 1977, Volume: 55, Issue:1 Topics: Acetylcysteine; Adolescent; Adult; Aged; Antifoaming Agents; Benzalkonium Compounds; Cocaine; Cornea; Dextrans; Female; Humans; Male; Methylcellulose; Middle Aged; Oils; Ointments; Ophthalmic Solutions; Petroleum; Pharmaceutical Vehicles; Polyethylene Glycols; Polyvinyl Alcohol; Silicones; Staining and Labeling; Stearic Acids	1977
Effect of N-acetylcysteine and deferoxamine on endogenous antioxidant defense system gene expression in a rat hepatocyte model of cocaine cytotoxicity. Biochimica et biophysica acta, 2000, Apr-17, Volume: 1496, Issue:2-3 Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cells, Cultured; Cocaine; Deferoxamine; Diploidy; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Hydrogen Peroxide; Liver; Male; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase	2000
Mitochondrial involvement in cocaine-treated rat hepatocytes: effect of N-acetylcysteine and deferoxamine. British journal of pharmacology, 2001, Volume: 132, Issue:5 Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Caspases; Chelating Agents; Cocaine; Cytochrome c Group; Deferoxamine; DNA Fragmentation; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Free Radical Scavengers; Heat-Shock Proteins; Hepatocytes; HSP20 Heat-Shock Proteins; Male; Membrane Potentials; Mitochondria, Liver; Muscle Proteins; Rats; Rats, Wistar	2001
N-acetylcysteine pretreatment decreases cocaine and endotoxin-induced hepatotoxicity. Journal of toxicology and environmental health. Part A, 2003, Feb-14, Volume: 66, Issue:3 Topics: Acetylcysteine; Animals; Cocaine; Endotoxins; Lipopolysaccharides; Liver; Liver Function Tests; Male; Mice; Oxidation-Reduction	2003
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nature neuroscience, 2003, Volume: 6, Issue:7 Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cystine; Dose-Response Relationship, Drug; Expectorants; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors	2003
Cocaine, not morphine, causes the generation of reactive oxygen species and activation of NF-kappaB in transiently cotransfected heart cells. Cardiovascular toxicology, 2003, Volume: 3, Issue:2 Topics: Acetylcysteine; Animals; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Free Radicals; Genes, Reporter; Glutathione; Morphine; Myocytes, Cardiac; Narcotics; NF-kappa B; Rats; Reactive Oxygen Species; Signal Transduction; Thioctic Acid; Transfection	2003
N-acetyl cysteine-induced blockade of cocaine-induced reinstatement. Annals of the New York Academy of Sciences, 2003, Volume: 1003 Topics: Acetylcysteine; Animals; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Microdialysis; Rats; Secondary Prevention	2003
Cocaine increases intracellular calcium and reactive oxygen species, depolarizes mitochondria, and activates genes associated with heart failure and remodeling. Cardiovascular toxicology, 2005,Fall, Volume: 5, Issue:4 Topics: Acetylcysteine; Animals; Calcium; Calcium Channel Blockers; Cocaine; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Glutathione; Heart Failure; Intracellular Membranes; Membrane Potentials; Microscopy, Confocal; Mitochondria; Myocytes, Cardiac; Narcotics; Oligonucleotide Array Sequence Analysis; Rabbits; Reactive Oxygen Species; Transcriptional Activation; Ventricular Function, Left; Ventricular Remodeling	2005
Unexpected cause of raised benzene absorption in coke oven by-product workers. Occupational medicine (Oxford, England), 2006, Volume: 56, Issue:4 Topics: Acetylcysteine; Air Pollutants, Occupational; Benzene; Coke; Environmental Monitoring; Humans; Metallurgy; Occupational Exposure; Protective Clothing; Skin Absorption	2006
Impairment in consolidation of learned place preference following dopaminergic neurotoxicity in mice is ameliorated by N-acetylcysteine but not D1 and D2 dopamine receptor agonists. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:3 Topics: Acetylcysteine; Animals; Behavior, Animal; Brain Chemistry; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione; Learning Disabilities; Male; Methamphetamine; Mice; Neurotoxicity Syndromes; Tyrosine 3-Monooxygenase	2007
Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Dec-19, Volume: 27, Issue:51 Topics: Acetylcysteine; Animals; Cocaine; Compulsive Behavior; Drug Administration Schedule; Male; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders	2007
Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:2 Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome	2011
N-Acetylcysteine reduces early- and late-stage cocaine seeking without affecting cocaine taking in rats. Addiction biology, 2012, Volume: 17, Issue:2 Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration	2012
The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biological psychiatry, 2012, Jun-01, Volume: 71, Issue:11 Topics: Acetylcysteine; Animals; Cocaine; Cystine; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; Free Radical Scavengers; Glutamic Acid; Male; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recurrence; Synaptic Transmission	2012
The cystine-glutamate transporter enhancer N-acetyl-L-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeys. Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:2 Topics: Acetylcysteine; Amino Acid Transport System y+; Animals; Behavior, Addictive; Cocaine; Corpus Striatum; Dopamine; Male; Saimiri; Self Administration	2012
Attenuating effect of N-acetyl-L-cysteine against acute cocaine toxicity in rat C6 astroglial cells. International journal of molecular medicine, 2013, Volume: 32, Issue:2 Topics: Acetylcysteine; Animals; Antioxidants; Astrocytes; Cell Line; Cell Survival; Cocaine; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Nitric Oxide; Oxidants; Rats	2013
Covalent thiol adducts arising from reactive intermediates of cocaine biotransformation. Chemical research in toxicology, 2013, Nov-18, Volume: 26, Issue:11 Topics: Acetylcysteine; Biotransformation; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme System; Glutathione; Humans; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Protein Isoforms; Quantum Theory; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds	2013
Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:8 Topics: Acetylcysteine; Animals; Cocaine; Conditioning, Operant; Glutamic Acid; Habits; Male; Membrane Potentials; Neostriatum; Neuronal Plasticity; Rats; Rats, Long-Evans	2014
Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction biology, 2015, Volume: 20, Issue:2 Topics: Acetylcysteine; Amino Acid Transport Systems, Acidic; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Transporter 2; Free Radical Scavengers; Inhibition, Psychological; Rats; Reinforcement, Psychology; Self Administration	2015
The effects of N-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression. Behavioural brain research, 2014, Jun-01, Volume: 266 Topics: Acetylcysteine; Animals; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Free Radical Scavengers; Male; Motor Activity; Olfactory Bulb; Rats; Rats, Wistar; Reward; Self Administration	2014
N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells. PloS one, 2015, Volume: 10, Issue:1 Topics: Acetylcysteine; Animals; Antioxidants; Astrocytes; Cell Line; Cell Membrane; Cell Survival; Cocaine; Cytoskeleton; Glutathione; Histones; Methylation; Rats; Reactive Oxygen Species	2015
N-acetylcysteine Facilitates Self-Imposed Abstinence After Escalation of Cocaine Intake. Biological psychiatry, 2016, 08-01, Volume: 80, Issue:3 Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Early Growth Response Protein 1; Electroshock; Excitatory Amino Acid Transporter 2; Male; Nucleus Accumbens; Punishment; Rats; Reinforcement Schedule; Self Administration; Time Factors	2016
N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement. Psychopharmacology, 2016, Volume: 233, Issue:18 Topics: Acetylcysteine; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cues; Depression; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Male; Olfactory Bulb; Rats; Rats, Wistar; Reward; Self Administration	2016
Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats. Psychopharmacology, 2016, Volume: 233, Issue:23-24 Topics: Acetylcysteine; Animals; Animals, Newborn; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Drug-Seeking Behavior; Free Radical Scavengers; Hippocampus; Male; Memory Disorders; Memory, Short-Term; Nicotine; Nicotinic Agonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley	2016
N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order. Drug and alcohol dependence, 2017, 09-01, Volume: 178 Topics: Acetylcysteine; Animals; Attentional Bias; Cocaine; Cocaine-Related Disorders; Cues; Double-Blind Method; Glutamic Acid; Humans; Motivation; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration	2017
Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine. The European journal of neuroscience, 2019, Volume: 50, Issue:3 Topics: Acetylcysteine; Animals; Behavior, Animal; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Heroin; Male; Reinforcement, Psychology; Self Administration	2019
Effects of chronic cocaine self-administration and N-acetylcysteine on learning, cognitive flexibility, and reinstatement in nonhuman primates. Psychopharmacology, 2019, Volume: 236, Issue:7 Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Cognition; Conditioning, Operant; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Free Radical Scavengers; Male; Photic Stimulation; Primates; Reinforcement, Psychology; Saimiri; Self Administration	2019
N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse. Addiction biology, 2020, Volume: 25, Issue:5 Topics: Acetylcysteine; Acute Disease; Alcohol-Related Disorders; Animals; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Drug-Seeking Behavior; Ethanol; Free Radical Scavengers; Male; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Stress, Psychological	2020
Urinary Mercapturic Acids to Assess Exposure to Benzene and Other Volatile Organic Compounds in Coke Oven Workers. International journal of environmental research and public health, 2020, 03-10, Volume: 17, Issue:5 Topics: Acetylcysteine; Benzene; Chromatography, Liquid; Coke; Europe; Humans; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Tandem Mass Spectrometry; Urinalysis; Volatile Organic Compounds	2020