acetylcysteine and carmustine

acetylcysteine has been researched along with carmustine in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19904 (21.05)18.7374
1990's4 (21.05)18.2507
2000's8 (42.11)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Hayes, MA; Pollanen, MS; Quinn, BA; Wollenberg, GK1
Hayes, MA; Murray, CA; Rushmore, TH1
Budini, R; Fraticelli, A; Guarnieri, C; Vaona, I; Ventura, C1
Berggren, M; Cotgreave, IA; Moldéus, PW; Sandy, MS; Smith, MT1
Ali-Osman, F; Maurer, HR; Meckert, C; Musil, J1
Ank, BJ; Aroda, VR; Roberts, RL1
Klee, S; Nürnberger, MC; Ungemach, FR1
Huyck, HL; Khalak, R; Pryhuber, GS1
Chen, G; Wang, SH; Warner, TD1
Baker, RD; Baker, SS; Gupta, A; Li, L; Rao, RK1
Aw, TY; Fujimoto, K; Iwakiri, R; Noda, T1
Chang, C; Chapman, PB; Fleisher, M; Hwu, WJ; Krown, SE; Livingston, PO; Pinto, JT; Williams, L; Wolchok, JD1
In Park, Y; Kweon, MH; Mukhtar, H; Sung, HC1
Abdel-Aziz, AA; El-Sayed, el-SM; Helal, GK; Saad, AS; Saleh, S1
An, JM; Kim, SS; Rhie, JH; Seo, JT; Seo, SR; Shin, DM1

Trials

1 trial(s) available for acetylcysteine and carmustine

ArticleYear
Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma.
    Melanoma research, 2003, Volume: 13, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antineoplastic Agents, Alkylating; Carmustine; Cohort Studies; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Glutathione; Glutathione Reductase; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Melanoma; Neoplasm Metastasis; Skin Neoplasms; Time Factors

2003

Other Studies

18 other study(ies) available for acetylcysteine and carmustine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Reversible mitochondrial swelling in cultured rat hepatocytes exposed to 1,2-dimethylhydrazine.
    Experimental and molecular pathology, 1990, Volume: 52, Issue:2

    Topics: 1,2-Dimethylhydrazine; Acetylcysteine; Animals; Carmustine; Cell Survival; Cells, Cultured; Dimethylhydrazines; Glutathione; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Maleates; Methylhydrazines; Mitochondria, Liver; Pinocytosis; Rats; Rats, Inbred F344

1990
Influences of glutathione status on different cytocidal responses of monolayer rat hepatocytes exposed to aflatoxin B1 or acetaminophen.
    Toxicology and applied pharmacology, 1986, Volume: 85, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Aflatoxin B1; Aflatoxins; Animals; Carmustine; Cells, Cultured; Drug Interactions; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Inbred F344

1986
External GSSG enhances intracellular glutathione level in isolated cardiac myocytes.
    Biochemical and biophysical research communications, 1987, Sep-15, Volume: 147, Issue:2

    Topics: Acetylcysteine; Animals; Carmustine; Cysteine; Glucose; Glutathione; Heart; Kinetics; Maleates; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred Strains

1987
N-acetylcysteine and glutathione-dependent protective effect of PZ51 (Ebselen) against diquat-induced cytotoxicity in isolated hepatocytes.
    Biochemical pharmacology, 1987, Sep-15, Volume: 36, Issue:18

    Topics: Acetylcysteine; Animals; Azoles; Carmustine; Diquat; Glutathione; Hydrogen Peroxide; Isoindoles; Lipid Peroxides; Liver; Male; Organoselenium Compounds; Oxidation-Reduction; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selenium

1987
Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU).
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:9

    Topics: Acetylcysteine; Animals; Carmustine; Cell Survival; Cells, Cultured; Clone Cells; Granulocytes; Leukemia L1210; Mice; Somatostatin

1984
N-acetylcysteine enhances antibody-dependent cellular cytotoxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients.
    The Journal of infectious diseases, 1995, Volume: 172, Issue:6

    Topics: Acetylcysteine; Adolescent; Adult; Antibody-Dependent Cell Cytotoxicity; Antioxidants; Carmustine; Child; Child, Preschool; Female; Glutathione; Granulomatous Disease, Chronic; HIV Infections; Humans; Infant; Leukocytes, Mononuclear; Male; Neutrophils

1995
The consequences of nitrofurantoin-induced oxidative stress in isolated rat hepatocytes: evaluation of pathobiochemical alterations.
    Chemico-biological interactions, 1994, Volume: 93, Issue:2

    Topics: Acetylcysteine; Animals; Carmustine; Deferoxamine; Dithiothreitol; Glutathione; Glutathione Reductase; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Nitrofurantoin; Oxidation-Reduction; Rats; Rats, Wistar; Stress, Physiological

1994
Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs.
    Experimental lung research, 1999, Volume: 25, Issue:6

    Topics: Acetylcysteine; Blotting, Northern; Carmustine; Cell Line; Clusterin; Drug Synergism; Epithelial Cells; Gene Expression Regulation; Glutathione; Glutathione Disulfide; Glutathione Reductase; Glycoproteins; Humans; Hydrogen Peroxide; Lung; Molecular Chaperones; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Pyrrolidines; Ribonucleases; RNA, Messenger; Thiocarbamates

1999
Regulation of iNOS mRNA levels in endothelial cells by glutathione, a double-edged sword.
    Free radical research, 2000, Volume: 32, Issue:3

    Topics: Acetylcysteine; Carmustine; Cell Line; Cytokines; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Stability; Gene Expression Regulation, Enzymologic; Glutathione; Glutathione Disulfide; Humans; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger

2000
Glutathione oxidation and PTPase inhibition by hydrogen peroxide in Caco-2 cell monolayer.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents, Alkylating; Caco-2 Cells; Carmustine; Catalase; Cell Membrane Permeability; Chelating Agents; Deferoxamine; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Intestinal Mucosa; Intestines; Iron; Maleates; Oxidants; Oxidation-Reduction; Phenanthrolines; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Sulfhydryl Compounds; Superoxide Dismutase; Thiomalates; Tight Junctions; Vitamin A; Vitamin E

2000
Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:12

    Topics: Acetylcysteine; Buthionine Sulfoximine; Caco-2 Cells; Carmustine; Cell Division; Cell Survival; Cytoplasm; Diamide; Epidermal Growth Factor; Glutathione; Glutathione Disulfide; Humans; Kinetics; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sulfhydryl Reagents

2001
The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2-dependent phase II detoxifying genes and alters intracellular glutathione redox.
    Free radical biology & medicine, 2006, Apr-15, Volume: 40, Issue:8

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Carmustine; Cells, Cultured; Dehydroepiandrosterone; Ferritins; Gene Expression Regulation; Glutathione; Heme Oxygenase-1; Humans; MAP Kinase Signaling System; Metabolic Detoxication, Phase II; NF-E2-Related Factor 2; Oxidation-Reduction; Phosphorylation; Quinic Acid; RNA, Messenger; Time Factors; Transcriptional Activation; Umbilical Cord

2006
Protective effect of N-acetylcysteine against carmustine-induced myelotoxicity in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:6

    Topics: Acetylcysteine; Animals; Antineoplastic Agents, Alkylating; Bone Marrow Cells; Carmustine; Male; Rats; Rats, Wistar

2010
Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:7

    Topics: Acetylcysteine; Animals; Antineoplastic Agents, Alkylating; Carmustine; Caspase 3; Cell Death; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Glutathione Reductase; MAP Kinase Kinase 4; Neurons; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species

2011