acetylcysteine has been researched along with buthionine sulfoximine in 247 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (2.43) | 18.7374 |
| 1990's | 70 (28.34) | 18.2507 |
| 2000's | 97 (39.27) | 29.6817 |
| 2010's | 70 (28.34) | 24.3611 |
| 2020's | 4 (1.62) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Chan, HM; Cherian, MG; Tabarrok, R; Tamura, Y | 1 |
| Black, PH; Levy, EM; Salibian, M; Wu, J | 1 |
| Lankhaar, G; Mulder, GJ; Polhuijs, M | 1 |
| Bray, GP; Tredger, JM; Williams, R | 1 |
| Hill, L; Lailey, AF; Lawston, IW; Stanton, D; Upshall, DG | 1 |
| Huang, HS; Jurima-Romet, M; Paul, CJ; Thomas, BH | 1 |
| Bellomo, G; Bertè, F; Colombo, P; Imberti, R; Mapelli, A; Richelmi, P | 1 |
| Kerem, D; Lalitha, T; Yannai, S | 1 |
| Corcoran, GB; Wong, BK | 1 |
| Yeung, JH | 1 |
| Honda, S; Matsuo, M | 1 |
| Berggren, M; Dawson, J; Moldéus, P | 1 |
| Birkett, DJ; Drew, R; Miners, JO | 1 |
| Mitchell, JB; Russo, A | 1 |
| Batres, L; Carrizales, L; Díaz-Barriga, F; Mejía, J; Ortíz, D; Ramos, O; Yáñez, L | 1 |
| Alexandre, E; Boudjema, K; Chenard, MP; Cinqualbre, J; Imbs, P; Jaeck, D; Nakano, H; Wolf, P | 1 |
| Malorni, W; Matarrese, P; Rivabene, R | 1 |
| Heintz, NH; Janssen, YM; Mossman, BT | 1 |
| Herzenberg, LA; Raju, PA; Roederer, M | 1 |
| Atalay, M; Hänninen, O; Sen, CK | 1 |
| Hori, K; Ishii, K; Katayama, M; Sato, N; Waga, S; Yodoi, J | 1 |
| Satriano, J; Schlondorff, D; Shan, Z; Silbiger, S; Tan, D | 1 |
| Barr, SG; Harrison, JJ; Racz, WJ; Rafeiro, E | 1 |
| Cabello Porras, MR; Cantoni, L; Carelli, M; Rizzardini, M | 1 |
| Baraban, JM; Murphy, TH; Ratan, RR | 1 |
| Mizutani, Y; Yoshida, O | 1 |
| Appenroth, D; Winnefeld, K | 1 |
| Faux, SP; Howden, PJ | 1 |
| Allouche, M; Bailly, JD; Bordier, C; Come, MG; Duchayne, E; Laurent, G; Mansat, V; Quillet-Mary, A | 1 |
| Chiba, T; Ishii, S; Kikuchi, K; Sato, N; Takahashi, S | 1 |
| Barger, SW; Hennig, B; Mattson, MP; McClain, CJ; Toborek, M | 1 |
| Fukuda, A; Hitomi, K; Osawa, T; Uchida, K | 1 |
| Borsellino, N; D'Alessandro, N; Flugy, A | 1 |
| Kim, HS; Kim, IK; Lee, JH | 1 |
| Endo, Y; Hatanaka, Y; Kawasaki, Y; Suzuki, K; Takei, N; Taniguchi, N | 1 |
| Bacon, BR; Bellezzo, JM; Britton, RS; Fox, ES; Neuschwander-Tetri, BA | 1 |
| Alexander, JM; Kang, YJ | 1 |
| Bernard-Pomier, G; Charpentier, B; Déas, O; Dumont, C; Hirsch, F; Métivier, D; Mollereau, B; Pasquier, C; Senik, A | 1 |
| Herman, AG; Matthys, KE; Zamora, R | 1 |
| Hirata, H; Kamata, H; Takeshita, H; Tanaka, C; Yagisawa, H | 1 |
| Gong, Q; Hart, BA | 1 |
| Greene, JJ; Hutter, DE; Till, BG | 1 |
| Duval, D; Froissard, P; Monrocq, H | 1 |
| Bhunia, AK; Chatterjee, S; Han, H; Snowden, A | 1 |
| Clark, JE; Foresti, R; Green, CJ; Motterlini, R | 1 |
| Arstrand, K; Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Collins, T; Fries, JW; Khachigian, LM | 1 |
| Han, D; Kobayashi, MS; Packer, L; Roy, S; Sen, CK; Tritschler, HJ | 1 |
| Hamilton, JW; Maccubbin, AE; Warren, AJ | 1 |
| Ding, Q; Mallery, SR; Opalenik, SR; Thompson, JA | 1 |
| Alexandre, E; Baek, Y; Boudjema, K; Jaeck, D; Kitamura, N; Kumada, K; Nagasaki, H; Nakano, H; Yamaguchi, M | 1 |
| Cornwell, DG; Jiang, Z; Jones, KH; Kohar, I; Lantry, LE; Southwell-Keely, P; Thornton, DE | 1 |
| Brash, DE; Chu, E; Ju, J; Liu, M; Pelling, JC | 1 |
| Hirota, N; Iida, M; Kuribayashi, N; Matsumoto, K; Sakagami, H; Sunaga, S; Takeda, M | 1 |
| Iida, T; Iwanaga, M; Kondo, T; Matsuo, T; Mori, K; Shibata, S; Urata, Y; Yasunaga, A | 1 |
| Beijersburgen van Henegouwen, GM; Steenvoorden, DP | 1 |
| Ansari, N; Kanji, V; Morrow, J; Pande, R; Parry, W; Poovala, V; Roberts, J; Salahudeen, A | 1 |
| Ingrassia, M; Maes, D; Mammone, T; Marenus, K; Pelle, E | 1 |
| Igisu, H; Matsuno, K; Matsuoka, M; Wispriyono, B | 1 |
| Bloom, ET; Furuke, K | 1 |
| Furuke, K; Gomi, T; Hirose, T; Ikai, I; Inamoto, T; Kawai, Y; Kinoshita, K; Nakamura, H; Nakamura, Y; Ohmori, K; Tsuyuki, S; Yamaoka, Y; Yamauchi, A | 1 |
| Biaglow, J; Held, K; Horan, AM; Koch, CJ; Manevich, Y; Tuttle, S | 1 |
| Brigelius-Flohé, R; Friedrichs, B; Müller, C | 1 |
| Balasubramanian, KA; Benard, O; Madesh, M | 1 |
| Shaikh, ZA; Vu, TT; Zaman, K | 1 |
| Averill, DA; Lord-Fontaine, S | 1 |
| Iwaoka, J; Komatsu, N; Muramatsu, T; Oda, T | 1 |
| de Groot, H; Möröy, T; Rauen, U; Rimpler, MM; Schmidt, T | 1 |
| Hamilton, JW; Liu, KJ; Wetterhahn, KE; Yuann, JM | 1 |
| Obermayr, RP; Piper, HM; Schäfer, M; Schlüter, KD; Spieckermann, PG | 1 |
| Fourneau, C; Gosset, P; Tonnel, AB; Wallaert, B | 1 |
| Cantoni, O; Palomba, L; Sestili, P | 1 |
| Hahn, LJ; Jeng, JH; Kuo, MY; Kuo, YS; Tsai, CL; Yang, PJ | 1 |
| Ong, CN; Shen, HM; Zhang, QF; Zhang, Z | 1 |
| Faustman, EM; Kavanagh, TJ; Krejsa, CM; Ou, YC; Ponce, RA; White, CC | 1 |
| Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Greene, JJ; Hutter, D | 1 |
| Haddad, JJ; Land, SC | 1 |
| Chen, CL; Chi, CW; Liu, TY | 1 |
| Liu, J; Ong, C; Shen, H; Yang, C | 1 |
| Asai, Y; Gon, Y; Hashimoto, S; Horie, T; Machino, T; Matsumoto, K; Takeshita, I | 1 |
| Ong, CN; Shen, HM; Yang, CF | 1 |
| Ladi, E; Mayer-Proschel, M; Noble, M; Smith, J | 1 |
| Birnboim, HC; Privora, H | 1 |
| Almazan, G; Chemtob, S; Khorchid, A; Liu, HN; Martinez-Bermudez, AK; Sundararajan, S | 1 |
| Ovrebø, KK; Svardal, A | 1 |
| Alaluf, S; Evans, A; Green, MR; Hu, HL; Muir-Howie, H | 1 |
| Gon, Y; Hashimoto, S; Horie, T; MacHino, T; Matsumoto, K; Takeshita, I | 1 |
| Bennett, LC; Hale, C; Muldoon, LL; Neuwelt, EA; Purcell, SE; Walker-Rosenfeld, SL | 1 |
| Natarajan, V; Parinandi, NL; Scribner, WM; Shi, S; Vepa, S | 1 |
| Domenico, KK; Doolittle, DJ; Knowlton, MS; Smith, CJ; Vannais, DB; Waldren, CA | 1 |
| Bogdanovic, E; Ennis, D; Fantus, C; Fantus, IG; Lai, R; Le-Tien, H; Lu, B; Nikolov, R; Salamon, L | 1 |
| Andrieu-Abadie, N; Carpentier, S; Gouazé, V; Levade, T; Mirault, ME; Salvayre, R | 1 |
| Boget, S; Cereser, C; Parvaz, P; Revol, A | 1 |
| Freitas, I; Griffini, P; Pietrocola, G; Richelmi, P; Vairetti, M | 1 |
| Aw, TY; Fujimoto, K; Iwakiri, R; Noda, T | 1 |
| Clayette, P; Dormont, D; Imbach, JL; Mialocq, P; Oiry, J; Puy, JY; Rimaniol, AC | 1 |
| Deloughery, TG; Hasler, BP; Muldoon, LL; Neuwelt, EA; Pagel, MA | 1 |
| Chan, C; Goldkorn, T; Kawcak, T; Lavrentiadou, SN; Rasooly, R; Ravid, T; Tsaba, A; van der Vliet, A | 1 |
| Carney, EW; Hansen, JM; Harris, C | 1 |
| Betti, M; Canesi, L; Ciacci, C; Gallo, G | 1 |
| Friedman, MA; Kamendulis, LM; Klaunig, JE; Park, J | 1 |
| Haddad, JJ | 2 |
| Ho, YS; Lee, HM; Lin, CH; Thum, WY; Wu, CH | 1 |
| Boulares, AH; Contreras, FJ; Espinoza, LA; Smulson, ME | 1 |
| Abe, S; Kim, HJ; Kobayashi, T; Kohyama, T; Liu, X; MacNee, W; Rahman, I; Rennard, SI; Romberger, DJ; Wang, H; Wen, FQ | 1 |
| Alsadi, S; Edgren, M; Hägglund, H; Hassan, M; Hassan, Z; Hellström-Lindberg, E | 1 |
| Harmon, J; Robertson, RP; Tanaka, Y; Tran, PO | 1 |
| Hashimoto, K; Iyo, M; Komatsu, N; Shimizu, E | 1 |
| Agapito, MT; Benavides, A; Ceña, V; Galindo, MF; González, C; González-García, C; Jordán, J; Tornero, D | 1 |
| Barale, R; Carnevali, S; Celi, A; Cipollini, M; Giuntini, C; Longoni, B; Paggiaro, P; Petruzzelli, S; Scatena, F; Vanacore, R | 1 |
| Orr, WC; Radyuk, SN; Sohal, RS | 1 |
| Mansfield, K; Nemelivsky, YV; Rajpurohit, R; Shapiro, IM; Teixeira, CC | 1 |
| Aksenov, ND; Efremova, TN; Gamaleĭ, IA; Kirpichnikova, KM | 1 |
| Fu, JL; Shen, DX; Shi, X; Zhang, YM; Zhou, ZC | 1 |
| Maki, D; Stapleton, SR; Xu, J | 1 |
| Barber, T; García, C; Miralles, VJ; Pallardó, FV; Rus, AD; Torres, L; Viña, JR; Zaragozá, R | 1 |
| Chevanne, M; Cillard, J; Cillard, P; Morel, I; Sergent, O; Sinbandhit-Tricot, S | 1 |
| Barelli, D; Cantoni, L; Castell, JV; Hauri, L; Mangolini, A; Ponsoda, X; Rizzardini, M; Valaperta, R; Villa, P | 1 |
| Cui, X; Hayakawa, T; Hirano, S; Kanno, S; Kobayashi, Y; Li, S; Shraim, A | 1 |
| Bryła, J; Drozak, J; Jagielski, AK; Wegrzynowicz, M; Winiarska, K | 1 |
| Hong, S; Kang, S; Kim, IY; Kim, SJ; Kim, TS; Rhim, H | 1 |
| Adjei, AA; Bone, N; Bruzek, LM; Chandra, J; Hackbarth, J; Karp, JE; Kaufmann, SH; Kay, NE; Le, S; Loegering, D; Narayanan, VL; Sausville, EA; Tefferi, A | 1 |
| Dorval, J; Hontela, A | 1 |
| Franklin, JL; Kirkland, RA | 1 |
| Irie, K; Maru, Y; Muraki, T; Ohba, K; Uchida, Y; Yoshioka, T | 1 |
| Hebbar, V; Hu, R; Keum, YS; Kim, BR; Kong, AN; Nair, SS; Shen, G | 1 |
| Birnboim, HC; Do, SK; Haqqani, AS | 1 |
| Hales, CA; Jafari, B; Li, LF; Ouyang, B; Quinn, DA | 1 |
| Ansorena, E; Cenarruzabeitia, E; Iraburu, MJ; López-Zabalza, MJ; Montiel-Duarte, C | 1 |
| Alba, G; Alvarez-Maqueda, M; Bedoya, FJ; Chacón, P; El Bekay, R; Martín-Nieto, J; Monteseirín, J; Pintado, E; Sobrino, F; Vega, A | 1 |
| Ong, CN; Shen, HM; Zhang, S | 1 |
| Nikinmaa, M; Pursiheimo, S; Soitamo, AJ | 1 |
| Dymkowska, D; Slyshenkov, VS; Wojtczak, L | 1 |
| Abe, S; Bitterman, P; Conner, H; Fang, Q; Kim, H; Kobayashi, T; Kohyama, T; Liu, X; Rennard, SI; Wen, FQ | 1 |
| Hansen, JM; Jones, DP; Watson, WH | 1 |
| Flanders, T; Lounsbury, KM; Mossman, BT; Shukla, A | 1 |
| Filipov, NM; Lawrence, DA; Seegal, RF | 1 |
| Hirata, H; Kakuta, J; Kamata, H; Oka, S; Shibukawa, Y | 1 |
| Lee, YJ; Shukla, SD | 1 |
| Arregui, B; Carbonell, LF; Fenoy, FJ; González-Mora, JL; Ruiz, F; Salom, MG | 1 |
| Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sawada, H; Shimohama, S; Yamamoto, N | 1 |
| El-Kadi, AO; Elbekai, RH | 1 |
| Foth, H; Glahn, F; Stehfest, E; Torky, A | 1 |
| Aller, P; Amrán, D; de Blas, E; Fernández, C; Ramos, AM; Sancho, P; Susin, SA; Yuste, VJ | 1 |
| Dwarte, TM; Luty, A; Raftos, JE; Willcock, CJ | 1 |
| Castegnaro, M; Faucet-Marquis, V; Pfohl-Leszkowicz, A; Pont, F; Rizk, T; Størmer, FC | 1 |
| Hong, H; Ji, ZN; Liu, GQ; Lu, Y | 1 |
| Calixto, JB; Echevarria-Lima, J; Leite, DF; Rumjanek, VM | 1 |
| Ahmad, IM; Dornfeld, KJ; Mattson, DM; Simons, AL; Spitz, DR | 1 |
| Pat, SW; Yang, MS; Yu, LC | 1 |
| Doneanu, CE; Niture, SK; Pattabiraman, N; Srivenugopal, KS; Velu, CS | 1 |
| Alaoui-Jamali, MA; Batist, G; Hamilton, D; Loignon, M | 1 |
| Fanjul-Moles, ML; Gonsebatt, ME; Hernández, NA; Limón-Pacheco, JH | 1 |
| Bi, Y; Huang, C; Li, N; Ma, Y; Wan, Q; Wang, X | 1 |
| Ginsburg, I; Kohen, R; Koren, E; Zverev, I | 1 |
| Harper, SL; Tanguay, RL; Usenko, CY | 1 |
| He, Q; Joseph, P; Umbright, C | 1 |
| Bienes-Martínez, R; Lucio-Cazana, J; Parra-Cid, T; Ramirez-Rubio, S; Reyes-Martin, P | 1 |
| Berglund, T; Greger, M; Landberg, T; Ohlsson, AB | 1 |
| Aoki, R; Numazawa, S; Sakaguchi, H; Taira, T; Yoshida, T | 1 |
| Daskal, I; Kwok, SC | 1 |
| Cao, J; Geng, C; Jiang, L; Xue, X; Yao, X; Zhang, X; Zhong, L | 1 |
| Chen, H; Shi, H | 1 |
| Ahmad, IM; Aykin-Burns, N; Dayal, D; Dornfeld, KJ; Li, L; Mattson, DM; Orcutt, KP; Parsons, AD; Simons, AL; Spitz, DR | 1 |
| Hsiao, CJ; Stapleton, SR | 1 |
| Becker, A; Soliman, KF | 1 |
| Carlson, L; Chen, W; Foll, R; Guan, X; Hanson, S; Matthees, DP; Palakurthi, S; Seefeldt, T; Stoebner, A; Zhao, Y | 1 |
| Li, HY; Wu, MR; Zhang, HS; Zhou, HS; Zhou, Y | 1 |
| Kalariya, NM; Ramana, KV; Srivastava, SK; van Kuijk, FJ; Wills, NK | 1 |
| Baruchello, R; D'Alessandro, N; Gueli, MC; Labbozzetta, M; Marchetti, P; Notarbartolo, M; Poma, P; Simoni, D | 1 |
| Han, YH; Park, WH | 3 |
| Chang, NC; Lai, PY; Lee, TM | 1 |
| Han, YH; Kim, SH; Kim, SZ; Park, WH | 1 |
| Han, YH; Kim, SH; Kim, SZ; Moon, HJ; Park, WH; You, BR | 1 |
| Biswas, S; Das, D; Mishra, MK; Mukhopadhyay, C; Mukhopadhyay, CK; Tapryal, N | 1 |
| Park, WH; You, BR | 5 |
| de Mello, CF; de Oliveira Ferreira, AP; Ferreira, J; Rossato, MF; Velloso, NA | 1 |
| Sevgiler, Y; Uner, N | 1 |
| Ahamed, M; Ahmad, I; Akhtar, MJ; Ashquin, M; Kumar, S; Patil, G; Siddiqui, H | 1 |
| Cai, DQ; Kim, DH; Kim, SK; Lee, KJ; Qi, XF; Shim, KY; Teng, YC; Yoon, YS | 1 |
| Borisenko, GG; Demina, IA; Galyamina, MA; Govorun, VM; Lazarev, VN; Levitskiy, SA; Serebryakova, MV; Shkarupeta, MM | 1 |
| Agarwal, C; Agarwal, R; Day, BJ; Huang, J; Tewari-Singh, N; White, CW | 1 |
| Bahar, M; Khaghani, S; Khorramizadeh, MR; Mirmiranpour, H; Nejad, SG; Paknejad, M; Pasalar, P | 1 |
| Bhattacharya, S; Chakraborty, A; Chattopadhyay, A; Podder, S; Ray, MR | 1 |
| Carey, JW; Ercal, N; Karacal, H; Penugonda, S; Pinarci, EY | 1 |
| Agrawal, K; George, W; Mondal, D; Petroni, D; Tsai, J | 1 |
| Chen, J; Gao, AC; Li, Y; Liu, C; Liu, H; Wang, T; Wu, Z; Zhou, Q; Zhu, Y | 1 |
| Akitaya, T; Kamiie, K; Kidachi, Y; Noshita, T; Ryoyama, K; Umetsu, H; Yamaguchi, H; Yoshida, K; Yu, T | 1 |
| Ahmadi-Ashtiani, H; Allameh, A; Barkhordari, E; Rastegar, H; Soleimani, M | 1 |
| Catarzi, S; Favilli, F; Iantomasi, T; Marcucci, T; Picariello, L; Romagnoli, C; Tonelli, F; Vincenzini, MT | 1 |
| Asano, N; Iijima, K; Kato, K; Kusaka, G; Shimosegawa, T; Uno, K | 1 |
| Gebicki, JM; Liu, CC | 1 |
| Arai, M; Hikita, E; Hirano, T; Onda, K; Tanaka, S; Toyoda, H; Utsumi, H; Yuan, B | 1 |
| Nazıroğlu, M; Özgül, C | 1 |
| Chen, X; Gan, F; Hesketh, J; Huang, K; Li, J; Ren, F; Shi, X | 1 |
| John, A; Raza, H | 1 |
| Suo, YR; Zhang, C; Zhao, YF | 1 |
| Kim, SH; Park, WH | 1 |
| Hayakawa, T; Ichinose, A; Matsuyama, A; Moriyama, H; Moriyama, M; Nishibata, Y; Okura, H; Ueda, A | 1 |
| Aon, MA; Booz, GW; Duhé, RJ; Kurdi, M; Paolocci, N; Sivakumaran, V | 1 |
| Ahmadi-Ashtiani, HR; Allameh, A; Mortaz, E; Rastegar, H; Saraf, Z | 1 |
| Appenzeller-Herzog, C; Christensen, B; Ellgaard, L; Geertz-Hansen, HM; Hansen, HG; Juncker, AS; Ramming, T; Schmidt, JD; Søltoft, CL; Sørensen, ES | 1 |
| Benoit-Vical, F; Berry, A; Gales, A; Huyghe, E; Njomnang Soh, P; Pipy, B; Witkowski, B | 1 |
| Brandi, ML; Favilli, F; Galli, G; Iantomasi, T; Marcucci, G; Mavilia, C; Romagnoli, C; Tanini, A; Vincenzini, MT; Zonefrati, R | 1 |
| Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Costa, VM; Fernandes, E; Ferreira, LM; Ferreira, PS; Meisel, A; Nogueira, TB | 1 |
| Andreu, AL; Bianchi, P; Ferrer, I; Fourcade, S; Galino, J; López-Erauskin, J; Muñoz-Pinedo, C; Pujol, A | 1 |
| Iantomasi, T; Marcucci, T; Picariello, L; Romagnoli, C; Tonelli, F; Vincenzini, MT | 1 |
| Ciğ, B; Nazıroğlu, M; Ozgül, C | 1 |
| Sima, YH; Wang, JW; Yang, WH; Zhang, J; Zhang, Z | 1 |
| Kaushik, G; Kaushik, T; Khanduja, KL; Pathak, CM; Ranawat, P; Sharma, SK; Yadav, SK | 1 |
| Chang, SW; Chung, JH; Kim, EC; Kim, YS; Lee, YM; Noh, K | 1 |
| Kayama, T; Kitanaka, C; Narita, Y; Okada, M; Sato, A; Seino, S; Shibui, S; Shibuya, K; Watanabe, E | 1 |
| Fontani, F; Iantomasi, T; Marcucci, T; Picariello, L; Tonelli, F; Vincenzini, MT | 1 |
| Clemens, DL; Dey, A; Kumar, SM; Swaminathan, K | 1 |
| Han, BR; Kim, SH; Park, WH; Shin, HR; You, BR | 1 |
| Jiang, H; Ma, L; Shen, Q; Tian, Y; Wang, L; Yu, L; Zeng, S; Zhou, H; Zhou, Q; Zuo, M | 1 |
| Aw, TY; Li, W; Maloney, RE | 1 |
| Chen, M; Ge, L; Guan, Y; Ji, F; Jiang, L; Liu, X; Wang, X; Yang, G; Zhong, L | 1 |
| Bhattacharya, S; Chakraborty, A; Chattopadhyay, A; Srivastava, R | 1 |
| Arenal, IPD; Guevara-Flores, A; Martínez-González, JJ; Rendón, JL | 1 |
| Chen, Y; Duan, S; Duan, Y; Han, J; Li, X; Li, Y; Ma, X; Sun, L; Xiang, R; Yang, X; Yao, H | 1 |
| Hou, Y; Hu, CA; Hu, S; Long, M; Mei, H; Wang, L; Wu, G; Yan, L; Yi, D | 1 |
| Gollavilli, PN; Gopoju, R; Karnewar, S; Kotamraju, S; Kumar, JM; Narra, SR; Vasamsetti, SB | 1 |
| Aykin-Burns, N; Banerjee, S; Hauer-Jensen, M; Krager, KJ; Melnyk, SB; Pawar, SA; Shah, SK | 1 |
| Colla, R; De Ciucis, C; Domenicotti, C; Fenoglio, D; Furfaro, AL; Izzotti, A; Marengo, B; Passalacqua, M; Pronzato, MA; Pulliero, A; Ravera, S; Ricciarelli, R; Speciale, A; Traverso, N | 1 |
| Ahamed, M; Akhtar, MJ; Alhadlaq, HA; Alshamsan, A | 1 |
| Park, WH | 1 |
| Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Alotaibi, MR; AlSaad, AM; Ansari, MA; Nadeem, A | 1 |
| Akhtar, F; Asmis, R; Catano, G; Kharbanda, K; Maffi, SK; Montalvo, M; Rouse, CA; Ullevig, SL | 1 |
| Bolay, C; Fernandes, AMM; Hiller, KA; Schmalz, G; Schweikl, H; Valera, MC; Vilela, PGF | 1 |
| Eliasson, P; Halvarsson, C; Jönsson, JI; Lang, S; Rörby, E; Soneji, S | 1 |
| Bonilla-Porras, AR; Jimenez-Del-Rio, M; Velez-Pardo, C | 1 |
| Chen, JG; Guan, XL; Wang, F; Wu, PF | 1 |
| Chen, Y; Davidson, EA; Orlicky, DJ; Thompson, B; Thompson, DC; Vasiliou, V | 1 |
| Cui, XY; Park, SH; Park, WH | 1 |
| Abhyankar, S; Adelusi, O; Apte, U; Dawn, B; Duan, L; Jaeschke, H; Nguyen, NT; Ramachandran, A; Robarts, DR; Soder, RP; Umbaugh, DS; Woolbright, B | 1 |
| Brimacombe, KR; Dulcey, AE; Goldsborough, AS; Gottesman, MM; Griffiths, G; Hall, MD; Handley, MD; Kannan, P; Pluchino, KM | 1 |
| Bolognese, BJ; Callahan, JF; Cottom, JE; Coyle, JE; Davies, TG; Feldser, HG; Foley, JP; Griffiths-Jones, C; Hearn, K; Heightman, TD; Kerns, JK; Kou, JP; Logan, G; McMenamin, R; Norton, D; Podolin, PL; Rich, SJ; Richardson, C; Sanchez, Y; Saxty, G; Willems, HM; Wixted, WE; Woolford, AJ; Yan, H; Yonchuk, JG | 1 |
1 review(s) available for acetylcysteine and buthionine sulfoximine
| Article | Year |
|---|---|
Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Survival; Cells, Cultured; Dermatitis; DNA; Female; Glutathione; Humans; Mice; Mice, Hairless; Mustard Gas; Peroxidase; Skin; Skinfold Thickness | 2011 |
246 other study(ies) available for acetylcysteine and buthionine sulfoximine
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in rats.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Induced Liver Injury; Cytosol; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Metallothionein; Methionine Sulfoximine; Phenobarbital; Potassium; Rats; Rats, Sprague-Dawley; Sulfates; Vitamin K; Zinc; Zinc Sulfate | 1992 |
The effect of changes in thiol subcompartments on T-cell colony formation and cell cycle progression: relevance to AIDS.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Buthionine Sulfoximine; Cell Compartmentation; Cell Cycle; Cells, Cultured; Colony-Forming Units Assay; Cyclohexanones; Humans; Mercaptoethanol; Methionine Sulfoximine; Protein Kinase C; Sulfhydryl Compounds; T-Lymphocytes | 1992 |
Relationship between glutathione content in liver and glutathione conjugation rate in the rat in vivo. Effect of buthionine sulphoximine pretreatment on conjugation of the two 2-bromoisovalerylurea enantiomers during intravenous infusion.
Topics: Acetylcysteine; Animals; Bromisovalum; Buthionine Sulfoximine; Glutathione; Infusions, Intravenous; Kinetics; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Stereoisomerism | 1992 |
S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mortality; S-Adenosylmethionine | 1992 |
Protection by cysteine esters against chemically induced pulmonary oedema.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cysteine; Cystine; DNA; Female; Fluorocarbons; Glutathione; Liver; Lung; Methionine Sulfoximine; Perfusion; Pulmonary Edema; Rats; Sulfhydryl Compounds; Time Factors | 1991 |
Enalapril cytotoxicity in primary cultures of rat hepatocytes. II. Role of glutathione.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Drug Synergism; Enalapril; Glutathione; Glutathione Reductase; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Male; Maleates; Methionine Sulfoximine; Rats; Rats, Inbred F344 | 1991 |
1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH.
Topics: 5'-Nucleotidase; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Animals; Antimetabolites; Aspartate Aminotransferases; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; gamma-Glutamyltransferase; Glutathione; Hemolysis; Male; Methionine Sulfoximine; Propane; Rats; Rats, Inbred Strains | 1990 |
Effect of N-acetyl-cysteine, D-penicillamine and buthionine sulfoximine on glutathione levels and CNS oxygen toxicity in rats.
Topics: Acetylcysteine; Administration, Oral; Animals; Brain; Buthionine Sulfoximine; Drinking; Electrocardiography; Glutathione; Glutathione Peroxidase; Injections, Intraperitoneal; Male; Methionine Sulfoximine; Penicillamine; Rats; Rats, Inbred Strains | 1990 |
Effects of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Esterases; Isoflurophate; Lysine; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Nitrophenols; Organophosphorus Compounds; Phenylmethylsulfonyl Fluoride | 1987 |
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds | 1988 |
Relationships between the cellular glutathione level and in vitro life span of human diploid fibroblasts.
Topics: Acetylcysteine; Antimetabolites; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Culture Media; Fibroblasts; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine | 1988 |
Glutathione biosynthesis in the isolated perfused rat lung: utilization of extracellular glutathione.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutamates; Glutathione; In Vitro Techniques; Lung; Male; Methionine Sulfoximine; Perfusion; Rats; Rats, Inbred Strains | 1984 |
Mechanism of action of paracetamol protective agents in mice in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Buthionine Sulfoximine; Cysteamine; Cysteine; Glutathione; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
Thiols, thiol depletion, and thermosensitivity.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cricetinae; Cysteine; Glutathione; Heat-Shock Proteins; Hot Temperature; Maleates; Methionine Sulfoximine; Oxidation-Reduction; Oxygen Consumption; Protein Biosynthesis; Sulfhydryl Compounds; Time Factors | 1983 |
Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels.
Topics: Acetylcysteine; Animals; Arsenic; Buthionine Sulfoximine; Female; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Methionine Sulfoximine; Rats; Rats, Wistar | 1995 |
Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver.
Topics: Acetylcysteine; Acid Phosphatase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Cold Temperature; Cysteine; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Oxidation-Reduction; Rats; Rats, Wistar; Reperfusion Injury | 1995 |
The antioxidant N-acetyl-cysteine protects cultured epithelial cells from menadione-induced cytopathology.
Topics: Acetylcysteine; Antimetabolites; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cell Adhesion; Epithelium; Glutamate-Cysteine Ligase; Humans; Methionine Sulfoximine; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Oxidative Stress; Tumor Cells, Cultured; Vitamin K | 1995 |
Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells.
Topics: Acetylcysteine; Asbestos, Crocidolite; Buthionine Sulfoximine; Genes, fos; Genes, jun; Glutathione; Humans; Methionine Sulfoximine; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Superoxide Dismutase | 1995 |
Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.
Topics: Acetylcysteine; Antimetabolites; Antioxidants; Antiviral Agents; Buthionine Sulfoximine; Cells, Cultured; Free Radical Scavengers; Gene Expression Regulation, Viral; Genes, Reporter; Glutathione; HIV Long Terminal Repeat; HIV-1; Humans; Leukocytes, Mononuclear; Methionine Sulfoximine; Monocytes; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha; Virus Replication | 1994 |
Exercise-induced oxidative stress: glutathione supplementation and deficiency.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Glutathione; Heart; Injections, Intraperitoneal; Kidney; Lipid Peroxides; Liver; Lung; Male; Methionine Sulfoximine; Muscle, Skeletal; Myocardium; Oxidative Stress; Physical Exertion; Random Allocation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 1994 |
Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX).
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Astrocytoma; Blotting, Western; Brain Neoplasms; Buthionine Sulfoximine; Cell Survival; Cerebral Cortex; Cytokines; Glutathione; Growth Substances; Humans; Hydrogen Peroxide; Mercaptoethanol; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Neoplasm Proteins; Neuroglia; Thioredoxins; Tumor Cells, Cultured | 1994 |
Intracellular glutathione influences collagen generation by mesangial cells.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Transformation, Viral; Cells, Cultured; Collagen; Culture Media; Glomerular Mesangium; Glucose; Glutathione; Methionine Sulfoximine; Mice; Oxidation-Reduction; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta | 1994 |
Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Dithiothreitol; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Mice; Sulfhydryl Compounds | 1994 |
Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Escherichia coli; Glutathione; Heme Oxygenase (Decyclizing); Lipopolysaccharides; Liver; Male; Methionine Sulfoximine; Mice; Oxidative Stress; RNA, Messenger; S-Adenosylmethionine | 1994 |
Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cells, Cultured; Cerebral Cortex; Cycloheximide; Cysteine; Glutamates; Glutathione; Homocysteine; Macromolecular Substances; Methionine Sulfoximine; Neurons; Oxidants; Protein Biosynthesis; Proteins; Rats | 1994 |
Overcoming tumor necrosis factor-alpha resistance of human renal and ovarian carcinoma cells by combination treatment with buthionine sulfoximine and tumor necrosis factor-alpha. Role of tumor necrosis factor-alpha mRNA down-regulation in tumor cell sensi
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Blotting, Northern; Buthionine Sulfoximine; Carcinoma, Renal Cell; Down-Regulation; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Kidney Neoplasms; Methionine Sulfoximine; Ovarian Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Role of glutathione for cisplatin nephrotoxicity in young and adult rats.
Topics: Acetylcysteine; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cisplatin; Drug Interactions; Female; Glutathione; Kidney; Methionine Sulfoximine; Rats; Rats, Wistar | 1993 |
Fibre-induced lipid peroxidation leads to DNA adduct formation in Salmonella typhimurium TA104 and rat lung fibroblasts.
Topics: Acetylcysteine; Animals; Antidotes; Asbestos, Crocidolite; Asbestos, Serpentine; Buthionine Sulfoximine; Carcinogens; Deferoxamine; DNA; DNA Adducts; Enzyme Inhibitors; Ferrozine; Fibroblasts; Glass; Glutathione; Lipid Peroxidation; Lung; Malondialdehyde; Methionine Sulfoximine; Mineral Fibers; Rats; Salmonella typhimurium; Thiobarbituric Acid Reactive Substances | 1996 |
Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Differentiation; Daunorubicin; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Methionine Sulfoximine; Nucleosomes; Pyrrolidines; Thiocarbamates; Tumor Cells, Cultured; Verapamil | 1996 |
Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Culture Media, Conditioned; Cycloheximide; Cysteine; Cytotoxicity, Immunologic; fas Receptor; Glutathione; Humans; Immunity, Innate; Intracellular Fluid; Killer Cells, Lymphokine-Activated; Leukemia, T-Cell; Lymphocyte Activation; Methionine Sulfoximine; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Role of glutathione redox cycle in TNF-alpha-mediated endothelial cell dysfunction.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Cell Membrane Permeability; Endothelium, Vascular; Glutathione; Lipid Peroxides; Methionine Sulfoximine; Oxidation-Reduction; Swine; Tumor Necrosis Factor-alpha | 1995 |
4-Hydroxy-2-nonenal cytotoxicity in renal proximal tubular cells: protein modification and redox alteration.
Topics: Acetylcysteine; Aldehydes; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cell-Free System; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules, Proximal; Kinetics; Muscle, Skeletal; Oxidation-Reduction; Proteins; Rabbits; Rats; Time Factors | 1996 |
TNF-induced apoptosis in multidrug resistant friend erythroleukemia is not influenced by the P-glycoprotein and glutathione status of the cell line.
Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Differentiation; Diuretics; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Ethacrynic Acid; Friend murine leukemia virus; Glutathione; Interferon-gamma; Leukemia, Erythroblastic, Acute; Mice; Recombinant Proteins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenites; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Division; Cycloheximide; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glutathione; Humans; Liver Neoplasms; Prostaglandin D2; Sodium Compounds; Structure-Activity Relationship; Sulfhydryl Compounds; Tumor Cells, Cultured | 1996 |
A role of peroxides in Ca2+ ionophore-induced apoptosis in cultured rat cortical neurons.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Calcium; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Indoles; Ionomycin; Ionophores; Kinetics; Neurons; Peroxides; Rats; Rats, Wistar; Superoxide Dismutase | 1996 |
Thiol regulation of endotoxin-induced release of tumour necrosis factor alpha from isolated rat Kupffer cells.
Topics: Acetylcysteine; Animals; Blotting, Northern; Buthionine Sulfoximine; Electrophoresis, Polyacrylamide Gel; Endotoxins; Glutathione; Kupffer Cells; Lipopolysaccharides; Liver; Male; Nuclear Proteins; Rats; Rats, Sprague-Dawley; RNA; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha | 1996 |
Alterations of the glutathione redox cycle status in fumonisin B1-treated pig kidney cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Carboxylic Acids; Carcinogens, Environmental; Catalase; Cell Survival; Cells, Cultured; Fumonisins; Glutathione; Kidney; Mycotoxins; Oxidation-Reduction; Superoxide Dismutase; Swine | 1996 |
Thiol-mediated inhibition of FAS and CD2 apoptotic signaling in activated human peripheral T cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; CD2 Antigens; Cells, Cultured; Cycloheximide; Dactinomycin; fas Receptor; Female; Glutathione; Humans; Lymphocyte Activation; Male; Signal Transduction; Sulfhydryl Compounds; T-Lymphocytes | 1997 |
The protective role of thiols against nitric oxide-mediated cytotoxicity in murine macrophage J774 cells.
Topics: Acetylcysteine; Animals; Benzoates; Buthionine Sulfoximine; Cell Line; Cell Survival; Enzyme Inhibitors; Glutathione; Hydroxylamine; Hydroxylamines; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds | 1997 |
Redox regulation of lipopolysaccharide (LPS)-induced interleukin-8 (IL-8) gene expression mediated by NF kappa B and AP-1 in human astrocytoma U373 cells.
Topics: Acetylcysteine; Antioxidants; Astrocytoma; Buthionine Sulfoximine; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Lipopolysaccharides; NF-kappa B; Oxidation-Reduction; Transcription Factor AP-1; Tumor Cells, Cultured | 1997 |
Effect of thiols on cadmium-induced expression of metallothionein and other oxidant stress genes in rat lung epithelial cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cadmium Chloride; Carcinogens; Cell Death; Cell Line; DNA Probes; Dose-Response Relationship, Drug; Epithelium; Gene Expression; Glutathione; Glutathione Transferase; Heme Oxygenase (Decyclizing); Kinetics; Lung; Metallothionein; Oxidoreductases; Rats; RNA, Messenger | 1997 |
Redox state changes in density-dependent regulation of proliferation.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Division; Cell Line; Contact Inhibition; Fibroblasts; Fibrosarcoma; Glutathione; Humans; Male; Neoplasm Proteins; Oxidation-Reduction; Protein Binding; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transcription Factors; Tumor Cells, Cultured | 1997 |
Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Culture Media, Serum-Free; Cycloheximide; Cystine; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Neurons; Oxidative Stress; PC12 Cells; Protein Synthesis Inhibitors; Rats | 1997 |
Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells.
Topics: Acetylcysteine; Antigens, CD; Antioxidants; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Inhibitors; Glutathione; Guanosine Triphosphate; Humans; Lactosylceramides; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Muscle, Smooth, Vascular; NADH, NADPH Oxidoreductases; NADPH Oxidases; Onium Compounds; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-fos; Signal Transduction; Superoxide Dismutase; Superoxides; Xanthine Oxidase | 1997 |
Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions.
Topics: Acetylcysteine; Animals; Aorta; Buthionine Sulfoximine; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Kinetics; Membrane Proteins; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sulfhydryl Compounds; Superoxides; Umbilical Veins | 1997 |
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microdialysis; Neoplasm Transplantation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Drug Synergism; Female; Free Radical Scavengers; Glomerular Mesangium; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; NF-kappa B; Promoter Regions, Genetic; Vascular Cell Adhesion Molecule-1 | 1997 |
Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Cell Survival; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Glutathione; Kinetics; Rats; Thioctic Acid; Tumor Cells, Cultured | 1997 |
Detection of mitomycin C-DNA adducts in vivo by 32P-postlabeling: time course for formation and removal of adducts and biochemical modulation.
Topics: Acetylcysteine; Animals; Biotransformation; Buthionine Sulfoximine; Chick Embryo; Cross-Linking Reagents; Dexamethasone; DNA; DNA Adducts; DNA Damage; DNA Repair; Enzyme Induction; Ethacrynic Acid; Glutathione; Glutethimide; Inactivation, Metabolic; Kidney; Liver; Lung; Mitomycin; Phosphorus Radioisotopes; Polychlorinated Biphenyls; Time Factors | 1998 |
Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor.
Topics: Acetylcysteine; Animals; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Culture Media, Conditioned; Enzyme Inhibitors; Fibroblast Growth Factor 1; Fibroblasts; Gene Products, tat; Glutamate-Cysteine Ligase; Glutathione; HIV-1; Mice; Mutagenesis; Oxidation-Reduction; tat Gene Products, Human Immunodeficiency Virus; Transfection | 1998 |
Efficacy of preconditioning with N-acetylcysteine against reperfusion injury after prolonged cold ischaemia in rats liver in which glutathione had been reduced by buthionine sulphoximine.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Buthionine Sulfoximine; Cold Temperature; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; In Vitro Techniques; Ischemic Preconditioning; Liver; Male; Oxidation-Reduction; Rats; Rats, Wistar; Reperfusion Injury | 1998 |
Cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells.
Topics: Acetylcysteine; Alkylating Agents; Buthionine Sulfoximine; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Glutathione; Humans; Leukemia, Lymphoid; Molecular Structure; Quinones; Tumor Cells, Cultured; Vitamin E | 1998 |
Antioxidant action via p53-mediated apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Dimercaprol; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glutathione; Mice; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E | 1998 |
Effect of glutathione-modulating compounds on hydrogen-peroxide-induced cytotoxicity in human glioblastoma and glioma cell lines.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glioblastoma; Glioma; Glutathione; Humans; Hydrogen Peroxide; Tumor Cells, Cultured | 1997 |
Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells.
Topics: Acetylcysteine; Antioxidants; Base Sequence; Binding Sites; Buthionine Sulfoximine; DNA Damage; DNA, Neoplasm; Enzyme Induction; Glioblastoma; Glutamate-Cysteine Ligase; Glutathione; Humans; Luciferases; NF-kappa B; Oxidative Stress; Promoter Regions, Genetic; Radiation Tolerance; RNA, Messenger; RNA, Neoplasm; Transfection; Tumor Cells, Cultured | 1998 |
Glutathione synthesis is not involved in protection by N-acetylcysteine against UVB-induced systemic immunosuppression in mice.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Glutathione; Immune Tolerance; Male; Mice; Mice, Inbred BALB C; Photobiology; Radiation-Protective Agents; Skin; Ultraviolet Rays | 1998 |
Cisplatin induces N-acetyl cysteine suppressible F2-isoprostane production and injury in renal tubular epithelial cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cells, Cultured; Cisplatin; Dinoprost; Epithelial Cells; Free Radicals; Glutathione; Humans; Hydrogen Peroxide; Kidney Tubules, Proximal; Lipid Metabolism; LLC-PK1 Cells; Models, Biological; Swine | 1998 |
Protection against cigarette smoke-induced damage to intact transformed rabbit corneal cells by N-acetyl-L-cysteine.
Topics: Acetylcysteine; Animals; Antidotes; Biological Assay; Buthionine Sulfoximine; Cell Line, Transformed; Cornea; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Nicotiana; Plants, Toxic; Rabbits; Smoke | 1998 |
Protection from cadmium cytotoxicity by N-acetylcysteine in LLC-PK1 cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cadmium; Cell Survival; Dactinomycin; Glutathione; Kidney; LLC-PK1 Cells; Proto-Oncogene Proteins c-fos; Swine | 1998 |
Redox-sensitive events in Fas-induced apoptosis in human NK cells include ceramide generation and protein tyrosine dephosphorylation.
Topics: Acetylcysteine; Antibodies, Monoclonal; Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspases; Cells, Cultured; Ceramides; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Glutamate-Cysteine Ligase; Glutathione; Humans; Interleukin-2; Killer Cells, Natural; Membrane Glycoproteins; Oxidation-Reduction; Phosphoproteins; Phosphorylation; Signal Transduction; Sulfhydryl Compounds; Transfection; Tyrosine | 1998 |
N-acetylcysteine improves cytotoxic activity of cirrhotic rat liver-associated mononuclear cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Division; Cytotoxicity, Immunologic; Glutathione; Killer Cells, Natural; Leukocytes, Mononuclear; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Inbred Strains; Thioacetamide; Tumor Cells, Cultured | 1998 |
Radiation-sensitive tyrosine phosphorylation of cellular proteins: sensitive to changes in GSH content induced by pretreatment with N-acetyl-L-cysteine or L-buthionine-S,R-sulfoximine.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; CHO Cells; Cricetinae; Cysteine; Free Radical Scavengers; Glutathione; Hydrogen Peroxide; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Reactive Oxygen Species; Signal Transduction | 1998 |
Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents.
Topics: Acetylcysteine; Arsenicals; Buthionine Sulfoximine; Cells, Cultured; E-Selectin; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Humans; Interleukin-1; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha | 1998 |
Glutathione modulates lipid composition of human colon derived HT-29 cells.
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cholesterol Esters; Colon; Diglycerides; Glutathione; HT29 Cells; Humans; Lipid Metabolism; Maleates; Sulfhydryl Compounds; Triglycerides | 1998 |
Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants.
Topics: Acetylcysteine; Alanine Transaminase; Amitrole; Animals; Anti-Inflammatory Agents; Antioxidants; Buthionine Sulfoximine; Cadmium; Cysteine; Drug Combinations; Enzyme Inhibitors; Female; Glutathione; Glycine; Glycyrrhetinic Acid; Kidney; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Malondialdehyde; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Steroids; Time Factors; Vitamin E | 1999 |
Enhancement of cytotoxicity of hydrogen peroxide by hyperthermia in chinese hamster ovary cells: role of antioxidant defenses.
Topics: Acetylcysteine; Amitrole; Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Cell Survival; CHO Cells; Cricetinae; Enzyme Inhibitors; Glutathione; Hot Temperature; Hydrogen Peroxide; Intracellular Fluid; Mesna; Oxidation-Reduction; Protective Agents; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
Involvement of N-acetylcysteine-sensitive pathways in ricin-induced apoptotic cell death in U937 cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspase Inhibitors; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; Microscopy, Fluorescence; Oxidative Stress; Protein Synthesis Inhibitors; Ricin; U937 Cells | 1999 |
Protection against hydrogen peroxide cytotoxicity in rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione.
Topics: Acetylcysteine; Adenosine Triphosphate; Aminoquinolines; Animals; Buthionine Sulfoximine; Calcium; Cell Death; Cell Line; Cell Survival; Fibroblasts; Fura-2; Glucose; Glutathione; Homeostasis; Hydrogen Peroxide; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Rats; Time Factors; Transfection | 1999 |
In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium(V), chromium-DNA binding and 8-hydroxy-2'-deoxyguanosine in liver and kidney of osteogenic disorder shionogi rats following treatment with chromium(VI).
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antimetabolites; Ascorbic Acid; Buthionine Sulfoximine; Chromium; Deoxyguanosine; DNA Adducts; Free Radical Scavengers; Glutathione; Ketones; Kidney; Liver; Oxidation-Reduction; Rats; Rats, Mutant Strains | 1999 |
Protection of reoxygenated cardiomyocytes against sarcolemmal fragility: the role of glutathione.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Hypoxia; Cells, Cultured; Glutathione; L-Lactate Dehydrogenase; Male; Myocardium; Osmolar Concentration; Oxygen; Rats; Rats, Wistar; Sarcolemma | 1999 |
Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages.
Topics: Acetylcysteine; Adult; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; DNA Primers; Female; Glutathione; Humans; Interleukin-6; Interleukin-8; Intracellular Fluid; Lipopolysaccharides; Macrophages, Alveolar; Male; Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 1999 |
The antioxidant butylated hydroxytoluene induces apoptosis in human U937 cells: the role of hydrogen peroxide and altered redox state.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; Butylated Hydroxytoluene; Catalase; Cytochrome P-450 Enzyme Inhibitors; DNA Fragmentation; Drug Combinations; Drugs, Chinese Herbal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Free Radical Scavengers; Glycyrrhiza; Humans; Hydrogen Peroxide; Iron Chelating Agents; Metyrapone; Oxidation-Reduction; Paeonia; Phenanthrolines; U937 Cells | 1999 |
Arecoline cytotoxicity on human oral mucosal fibroblasts related to cellular thiol and esterase activities.
Topics: Acetylcysteine; Antimetabolites; Areca; Arecoline; Atropine; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Esterases; Expectorants; Fibroblasts; Ganglionic Stimulants; Humans; Maleates; Mouth Mucosa; Muscarinic Antagonists; Plants, Medicinal; Sulfhydryl Compounds; Thiolester Hydrolases | 1999 |
Critical role of GSH in silica-induced oxidative stress, cytotoxicity, and genotoxicity in alveolar macrophages.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; DNA Damage; Glutathione; Hydrogen Peroxide; Intracellular Membranes; Macrophages, Alveolar; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Silicon Dioxide | 1999 |
The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells.
Topics: Acetylcysteine; Aminoacyltransferases; Animals; Buthionine Sulfoximine; Cell Differentiation; Central Nervous System; Embryo, Mammalian; Enzyme Inhibitors; Extremities; Flow Cytometry; Free Radical Scavengers; Glutathione; Homeostasis; Methylmercury Compounds; Neurons; Oxidative Stress; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 1999 |
Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Influence of the cellular redox state on NF-kappaB-regulated gene expression.
Topics: Acetylcysteine; Alkaline Phosphatase; Buthionine Sulfoximine; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Fibrosarcoma; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Glutathione; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Neoplasm Proteins; NF-kappa B; Oxidation-Reduction; Promoter Regions, Genetic; Recombinant Proteins; Simian virus 40; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2000 |
The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and requires NF-kappaB (RelA)-selective targeting.
Topics: Acetylcysteine; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Buthionine Sulfoximine; Dipeptides; DNA Fragmentation; Enzyme Inhibitors; Epithelium; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Models, Biological; NF-kappa B; Oxidation-Reduction; Oxygen; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pulmonary Alveoli; Pyrrolidines; Sulfasalazine; Thiocarbamates | 2000 |
Enhanced hydroxychavicol-induced cytotoxic effects in glutathione-depleted HepG2 cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Catalase; Cell Survival; Deoxyguanosine; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Electrons; Eugenol; Free Radical Scavengers; Glutathione; Humans; Liver Neoplasms; Mutagens; Oxidative Stress; Reactive Oxygen Species; Time Factors; Tumor Cells, Cultured | 2000 |
Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Glutathione; Growth Inhibitors; Humans; Intracellular Fluid; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sodium Selenite; Tumor Cells, Cultured | 2000 |
Regulation by intracellular glutathione of TNF-alpha-induced p38 MAP kinase activation and RANTES production by human pulmonary vascular endothelial cells.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cells, Cultured; Chemokine CCL5; Endothelium, Vascular; Glutathione; Humans; Imidazoles; Immunoblotting; Lung; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Pyridines; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Intracellular thiol depletion causes mitochondrial permeability transition in ebselen-induced apoptosis.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Azoles; Buthionine Sulfoximine; Calcium; Caspase 3; Caspase 9; Caspases; Cyclosporine; Cytochrome c Group; Egtazic Acid; Humans; Isoindoles; Membrane Potentials; Mitochondria, Liver; Organoselenium Compounds; Permeability; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Tumor Cells, Cultured | 2000 |
Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Cell Differentiation; Cells, Cultured; Flow Cytometry; Homeostasis; Neuroglia; Optic Nerve; Oxidants; Oxidation-Reduction; Platelet-Derived Growth Factor; Rats; Stem Cells; tert-Butylhydroperoxide | 2000 |
Depletion of intracellular glutathione reduces mutations by nitric oxide-donating drugs.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Gamma Rays; Glutathione; Hypoxanthine Phosphoribosyltransferase; Mice; Mutagenesis; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; Nitroprusside; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 2000 |
Exposure of developing oligodendrocytes to cadmium causes HSP72 induction, free radical generation, reduction in glutathione levels, and cell death.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cadmium; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Free Radicals; Glutathione; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Oligodendroglia; Oxidative Stress; Rats | 2000 |
The effect of glutathione modulation on the concentration of homocysteine in plasma of rats.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Chromatography, Liquid; Enzyme Inhibitors; Expectorants; Fasting; Glutathione; Hemodynamics; Homocysteine; Male; Rats; Rats, Wistar; Sulfhydryl Compounds | 2000 |
Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione.
Topics: Acetylcysteine; Antioxidants; Buthionine Sulfoximine; Cell Differentiation; Cells, Cultured; Clone Cells; DNA; Fibroblasts; Glutathione; Humans; Hydrogen Peroxide; Infant, Newborn; Male; Mitosis; Oxidative Stress; Oxygen; Phenotype; Skin; Skin Physiological Phenomena | 2000 |
Intracellular glutathione regulates tumour necrosis factor-alpha-induced p38 MAP kinase activation and RANTES production by human bronchial epithelial cells.
Topics: Acetylcysteine; Bronchi; Buthionine Sulfoximine; Cell Line, Transformed; Chemokine CCL5; Enzyme Activation; Epithelial Cells; Gene Expression Regulation; Glutathione; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Tumor Necrosis Factor-alpha | 2001 |
Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.
Topics: Acetylcysteine; Alkylating Agents; Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Carboplatin; Cell Survival; Cytoprotection; Drug Interactions; Humans; Molecular Weight; Protective Agents; Thiosulfates; Time Factors; Tumor Cells, Cultured | 2001 |
Phospholipase D activation in endothelial cells is redox sensitive.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Cattle; Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Intracellular Fluid; Oxidation-Reduction; Phospholipase D; Phosphorylation; Phosphotyrosine; Pulmonary Artery; Reactive Oxygen Species; Sulfhydryl Compounds; Sulfhydryl Reagents; Thiourea; Tiopronin | 1999 |
The role of glutathione in the toxicity of smoke condensates from cigarettes that burn or heat tobacco.
Topics: Acetylcysteine; Aerosols; Animals; Buthionine Sulfoximine; Cell Survival; CHO Cells; Chromosomes, Human, Pair 11; Cricetinae; Cricetulus; Enzyme Inhibitors; Free Radical Scavengers; gamma-Glutamyltransferase; Glutathione; Humans; Hybrid Cells; Nicotiana; Oxidation-Reduction; Oxidative Stress; Plants, Toxic; Smoke | 2001 |
Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4).
Topics: Acetylcysteine; Adipocytes; Animals; Buthionine Sulfoximine; Electron Spin Resonance Spectroscopy; Glucose; Glutathione; Insulin Resistance; Male; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Insulin; Recombinant Proteins; Vanadates | 2001 |
Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Buthionine Sulfoximine; Ceramides; Doxorubicin; Drug Interactions; Free Radical Scavengers; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Reactive Oxygen Species; Signal Transduction; Transfection; Tumor Cells, Cultured | 2001 |
Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death.
Topics: Acetylcysteine; Adult; Buthionine Sulfoximine; Cell Death; Cell Division; Cell Survival; Cells, Cultured; Female; Fibroblasts; Fungicides, Industrial; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Lipid Peroxidation; Oxidation-Reduction; Thiobarbituric Acid Reactive Substances; Thiram | 2001 |
Cold-induced apoptosis in isolated rat hepatocytes: protective role of glutathione.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cold Temperature; Glutathione; Hepatocytes; Hypothermia; Lipid Peroxidation; Male; Maleates; Rats; Rats, Wistar; Reactive Oxygen Species; Rewarming | 2001 |
Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cells.
Topics: Acetylcysteine; Buthionine Sulfoximine; Caco-2 Cells; Carmustine; Cell Division; Cell Survival; Cytoplasm; Diamide; Epidermal Growth Factor; Glutathione; Glutathione Disulfide; Humans; Kinetics; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sulfhydryl Reagents | 2001 |
[Oxidative metabolism of HIV-infected macrophages: the role of glutathione and a pharmacologic approach].
Topics: Acetylcysteine; Anti-HIV Agents; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Cysteamine; Drug Evaluation, Preclinical; Glutathione; HIV-1; Humans; Macrophages; Oxidative Stress; Prodrugs; Tumor Necrosis Factor-alpha; Virus Replication | 2001 |
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.
Topics: Acetylcysteine; Animals; Antimetabolites; Antineoplastic Agents, Alkylating; Aorta, Thoracic; Blood-Brain Barrier; Bone Marrow Diseases; Brain; Brain Neoplasms; Buthionine Sulfoximine; Carcinoma, Small Cell; Dose-Response Relationship, Drug; Drug Interactions; Female; Glutathione; Infusions, Intra-Arterial; Lung Neoplasms; Rats; Rats, Long-Evans; Tissue Distribution; Xenograft Model Antitumor Assays | 2001 |
Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione.
Topics: Acetylcysteine; Amitrole; Annexin A5; Antioxidants; Apoptosis; Bronchi; Buthionine Sulfoximine; Catalase; Cells, Cultured; Ceramides; Diacylglycerol Kinase; Dithiothreitol; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flow Cytometry; Glutathione; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Mercaptoethanol; Microscopy, Fluorescence; Oxidation-Reduction; Oxidative Stress; Pulmonary Alveoli; Reactive Oxygen Species; Trachea | 2001 |
Altered differentiation in rat and rabbit limb bud micromass cultures by glutathione modulating agents.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Differentiation; Cell Survival; Cells, Cultured; Chondrogenesis; Cysteine; Glutathione; Limb Buds; Malates; Oxidation-Reduction; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Staining and Labeling | 2001 |
Growth factor-mediated signal transduction and redox balance in isolated digestive gland cells from Mytilus galloprovincialis Lam.
Topics: Acetylcysteine; Animals; Bivalvia; Buthionine Sulfoximine; Copper; Digestive System; Epidermal Growth Factor; Free Radical Scavengers; Glutamate-Cysteine Ligase; Glutathione; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Oxidation-Reduction; Phosphofructokinase-1; Pyruvate Kinase; Signal Transduction; Time Factors | 2000 |
Acrylamide-induced cellular transformation.
Topics: Acetylcysteine; Acrylamide; Animals; Buthionine Sulfoximine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Drug Combinations; Embryo, Mammalian; Enzyme Inhibitors; Glutathione; Mesocricetus; Triazoles | 2002 |
The involvement of L-gamma-glutamyl-L-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPK(p38)-dependent regulation of pro-inflammatory cytokine production.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cells, Cultured; Cytokines; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Interleukin-6; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2002 |
Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Glycation End Products, Advanced; Imidazoles; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Polylysine; Polymyxin B; Prostaglandin-Endoperoxide Synthases; Pyridines; Reactive Oxygen Species | 2002 |
Roles of oxidative stress and glutathione depletion in JP-8 jet fuel-induced apoptosis in rat lung epithelial cells.
Topics: Acetylcysteine; Animals; Apoptosis; Benzamides; Buthionine Sulfoximine; Caspase 3; Caspases; Epithelial Cells; Free Radical Scavengers; Glutathione; Hydrocarbons; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Teratogens | 2002 |
Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Line; Collagen; Fibroblasts; Fibronectins; Gels; Glutathione; Humans; Intracellular Membranes; Nicotiana; RNA, Messenger; Smoke | 2002 |
The effect of modulation of glutathione cellular content on busulphan-induced cytotoxicity on hematopoietic cells in vitro and in vivo.
Topics: Acetylcysteine; Animals; Antigens, CD34; Antineoplastic Agents, Alkylating; Area Under Curve; Bone Marrow Cells; Busulfan; Buthionine Sulfoximine; Cell Death; Colony-Forming Units Assay; Erythroid Precursor Cells; Glutathione; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred BALB C | 2002 |
A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity.
Topics: Acetylcysteine; Adenoviridae; Animals; Antioxidants; Buthionine Sulfoximine; Cell Line; Enzyme Inhibitors; Gene Expression; Glucose; Glutamate-Cysteine Ligase; Glutathione Peroxidase; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Models, Biological; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Ribose; RNA, Messenger; Transfection | 2002 |
Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells.
Topics: Acetylcysteine; Apoptosis; Benzimidazoles; Brain Neoplasms; Buthionine Sulfoximine; Cystine; DNA Fragmentation; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Humans; Neuroblastoma; Neurons; Oxidopamine; Sympatholytics; Tumor Cells, Cultured | 2002 |
Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Caspases; Catalase; Cattle; Cell Survival; Chromaffin Cells; Cyclosporine; Cytochrome c Group; Enzyme Activation; Glutathione; Metalloporphyrins; Mitochondria; Permeability; Superoxides; Veratridine; Vitamin E | 2002 |
Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts.
Topics: Acetylcysteine; Apoptosis; Benzimidazoles; Buthionine Sulfoximine; Comet Assay; DNA Damage; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Humans; Lung; Microscopy, Confocal; Oxidative Stress; Smoking | 2003 |
Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells.
Topics: Acetylcysteine; Animals; Base Sequence; Blotting, Western; Buthionine Sulfoximine; Cell Death; Cell Line; Cytoprotection; DNA Primers; Drosophila melanogaster; Gene Silencing; Hot Temperature; Hydrogen Peroxide; Neoplasm Proteins; Paraquat; Peroxidases; Peroxiredoxins; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Maturation-dependent thiol loss increases chondrocyte susceptibility to apoptosis.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Apoptosis; Buthionine Sulfoximine; Cell Differentiation; Cell Survival; Cells, Cultured; Chick Embryo; Chondrocytes; Collagen Type II; Collagen Type IX; Cysteine; Fluorescent Dyes; Gene Expression; Glutathione; Growth Plate; Nitric Oxide; Osteopontin; Oxidation-Reduction; Oxidative Stress; Sialoglycoproteins; Sulfhydryl Compounds; Tretinoin | 2003 |
[Effect of agents changing the intracellular level of reactive oxygen species on the cell cycle phase distribution in 3T3 and 3T3SV40 cell lines].
Topics: 3T3 Cells; Acetylcysteine; Animals; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line, Transformed; Dose-Response Relationship, Drug; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2003 |
The role of thiol reduction in hydroquinone-induced apoptosis in HEK293 cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Glutathione; Humans; Hydroquinones; Kidney; Oxidation-Reduction; Sulfhydryl Compounds | 2003 |
Mediation of cadmium-induced oxidative damage and glucose-6-phosphate dehydrogenase expression through glutathione depletion.
Topics: Acetylcysteine; Animals; Blotting, Northern; Buthionine Sulfoximine; Cadmium; Enzyme Inhibitors; Glucosephosphate Dehydrogenase; Glutathione; Hepatocytes; L-Lactate Dehydrogenase; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2003 |
Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione.
Topics: Acetylcysteine; Alkynes; Animals; Base Sequence; Buthionine Sulfoximine; Cystathionine gamma-Lyase; DNA Primers; Female; gamma-Glutamyltransferase; Gene Expression Regulation; Glutathione; Glycine; Lactation; Liver; Mammary Glands, Animal; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sulfur; Weaning | 2003 |
Glutathione depletion increases nitric oxide-induced oxidative stress in primary rat hepatocyte cultures: involvement of low-molecular-weight iron.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cells, Cultured; Deferiprone; Ditiocarb; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Glutathione; Hepatocytes; Interferon-gamma; Iron; Iron Chelating Agents; Lipid Peroxidation; Lipopolysaccharides; Liver; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oxidative Stress; Pyridones; Rats; Rats, Sprague-Dawley | 2003 |
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Oxidative Stress; Rats | 2003 |
Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells.
Topics: Acetylcysteine; Animals; Antioxidants; Arsenates; Arsenites; Biological Transport; Buthionine Sulfoximine; Cell Death; Cell Division; Cell Survival; Cells, Cultured; Drug-Related Side Effects and Adverse Reactions; Endothelium, Vascular; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; NADP; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Rats; Thioredoxins | 2003 |
Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Gluconeogenesis; Glutathione; Intracellular Membranes; Kidney Cortex; Kidney Tubules; Male; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Rabbits; Thiazoles; Thiazolidines | 2003 |
Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells.
Topics: Acetylcysteine; Animals; Ataxin-1; Ataxins; Buthionine Sulfoximine; Cell Aggregation; Cell Death; Fluorescent Antibody Technique; Free Radical Scavengers; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrogen Peroxide; Immunoblotting; Luminescent Proteins; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Oxidants; Oxidative Stress; Peptides; Radiation-Protective Agents; Rats; tert-Butylhydroperoxide; Time Factors; Transfection | 2003 |
Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells.
Topics: Acetylcysteine; Adamantane; Antioxidants; Apoptosis; Buthionine Sulfoximine; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Glutathione; Humans; Hydroquinones; K562 Cells; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Neoplasm Proteins; Neoplastic Stem Cells; Quinones; Reactive Oxygen Species; Tumor Stem Cell Assay; Tyrphostins | 2003 |
Role of glutathione redox cycle and catalase in defense against oxidative stress induced by endosulfan in adrenocortical cells of rainbow trout (Oncorhynchus mykiss).
Topics: Acetylcysteine; Adrenal Cortex; Amitrole; Animals; Buthionine Sulfoximine; Catalase; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Endosulfan; Glutathione; Insecticides; Kidney; Lipid Peroxidation; Lipid Peroxides; Oncorhynchus mykiss; Oxidation-Reduction; Oxidative Stress | 2003 |
Prooxidant effects of NGF withdrawal and MEK inhibition in sympathetic neurons.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cycloheximide; Fetus; Flavonoids; Glutathione; MAP Kinase Signaling System; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factor; Neurons; Pyrazoles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superior Cervical Ganglion; Sympathetic Nervous System | 2003 |
Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Adipocytes; Aldehydes; Animals; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Free Radical Scavengers; Glycation End Products, Advanced; Lipid Peroxidation; Male; NF-kappa B; Oxidative Stress; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred OLETF; Reactive Oxygen Species; RNA, Messenger; Up-Regulation | 2004 |
Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspases; Cell Line, Tumor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Isothiocyanates; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Response Elements; Sulfoxides; Thiocyanates | 2003 |
The role of a formaldehyde dehydrogenase-glutathione pathway in protein S-nitrosation in mammalian cells.
Topics: Acetylcysteine; Aldehyde Oxidoreductases; Animals; Buthionine Sulfoximine; Cells, Cultured; Cysteine; Dehydroepiandrosterone; Glutathione; Glutathione Reductase; HeLa Cells; Humans; Mice; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitrosation; Proteins; RNA, Small Interfering; S-Nitrosoglutathione; S-Nitrosothiols | 2003 |
Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells.
Topics: Acetylcysteine; Antioxidants; Blotting, Northern; Buthionine Sulfoximine; Cells, Cultured; Cytokines; Epithelial Cells; Glutathione; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Isoprostanes; Lipid Peroxidation; NF-kappa B; Oxidative Stress; Pulmonary Alveoli; Respiratory Distress Syndrome; Stress, Mechanical; Transcription Factor AP-1 | 2004 |
Role of reactive oxygen species, glutathione and NF-kappaB in apoptosis induced by 3,4-methylenedioxymethamphetamine ("Ecstasy") on hepatic stellate cells.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cells, Cultured; Drug Interactions; Glutathione; Hepatocytes; N-Methyl-3,4-methylenedioxyamphetamine; NF-kappa B; Oxidative Stress; Quinine; Rats; Reactive Oxygen Species; Stellate Ganglion; Vitamin K 3 | 2004 |
15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.
Topics: Acetylcysteine; Allopurinol; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Chromans; Cyclic N-Oxides; Cyclopentanes; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ions; Lymphocytes; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthrolines; Phosphatidylinositol 3-Kinases; Prostaglandin D2; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Temperature; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Xanthine Oxidase | 2004 |
Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Buthionine Sulfoximine; Calcium; Cell Line, Tumor; Colorectal Neoplasms; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Humans; Oxidation-Reduction; Reactive Oxygen Species; Sesquiterpenes; Sulfhydryl Compounds | 2004 |
Redox state regulates HIF-1alpha and its DNA binding and phosphorylation in salmonid cells.
Topics: Acetylcysteine; Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cell Line; Cysteine; Dimerization; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Oncorhynchus mykiss; Oxidation-Reduction; Oxidative Stress; Oxygen; Phosphorylation; Proline; Propyl Gallate; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; RNA; Time Factors; Transcription Factors; Transcriptional Activation | 2004 |
Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics.
Topics: Acetylcysteine; Buthionine Sulfoximine; Energy Metabolism; Glutathione; Humans; Jurkat Cells; Kinetics; Pantothenic Acid | 2004 |
Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen; DNA; DNA Damage; Fibroblasts; Flow Cytometry; Glutathione; Humans; In Situ Nick-End Labeling; Lung; Oxidants; Rats; Smoking; Time Factors | 2004 |
Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1.
Topics: Acetylcysteine; Binding Sites; Buthionine Sulfoximine; Cell Nucleus; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutathione; HeLa Cells; Humans; Hydroquinones; NF-E2-Related Factor 2; Oxidation-Reduction; Signal Transduction; Thioredoxins; Trans-Activators; Transfection | 2004 |
The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity.
Topics: Acetylcysteine; Animals; Asbestos; Buthionine Sulfoximine; DNA; ErbB Receptors; Glutamate-Cysteine Ligase; Glutathione; Mice; Oxidation-Reduction; Proto-Oncogene Proteins c-fos; Transcription Factor AP-1; Transcriptional Activation | 2004 |
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cells, Cultured; Chromans; Cytokines; Enzyme Inhibitors; Inflammation; L-Lactate Dehydrogenase; Lipopolysaccharides; Manganese Poisoning; Mice; Microglia; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pentoxifylline; Phosphodiesterase Inhibitors; Serine Proteinase Inhibitors; Tosylphenylalanyl Chloromethyl Ketone | 2005 |
Redox regulation of nerve growth factor-induced neuronal differentiation of PC12 cells through modulation of the nerve growth factor receptor, TrkA.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Differentiation; Glutathione; Nerve Growth Factor; Neurons; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Receptor, trkA; Signal Transduction; Transcription Factor AP-1 | 2005 |
Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes.
Topics: Acetaldehyde; Acetylcysteine; Animals; Anthracenes; Apoptosis; Blotting, Western; Butadienes; Buthionine Sulfoximine; Caspase 3; Caspases; Cell Nucleus; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ethanol; Genistein; Hepatocytes; Hydrogen Peroxide; Indoles; JNK Mitogen-Activated Protein Kinases; Male; Maleates; Maleimides; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors | 2005 |
Renal ischemia induces an increase in nitric oxide levels from tissue stores.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Ischemia; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2005 |
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.
Topics: Acetylcysteine; Analysis of Variance; Area Under Curve; Buthionine Sulfoximine; Catalase; Cell Death; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cystine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Indolequinones; Iron; Melanins; Models, Biological; Neuroblastoma; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+.
Topics: Acetylcysteine; Animals; Arsenites; Buthionine Sulfoximine; Cadmium Chloride; Cell Line, Tumor; Chromium Compounds; Cytochrome P-450 CYP1A1; Down-Regulation; Drug Synergism; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Heme Oxygenase-1; Membrane Proteins; Mice; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Oxidative Stress; Receptors, Aryl Hydrocarbon; Sodium Compounds | 2005 |
Non-destructive micromethod for MRP1 functional assay in human lung tumor cells.
Topics: Acetylcysteine; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Buthionine Sulfoximine; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Fluorometry; Glutathione; Humans; Immunohistochemistry; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Sensitivity and Specificity; Verapamil | 2006 |
Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress.
Topics: Acetylcysteine; Adenosine Triphosphate; Antimetabolites, Antineoplastic; Apoptosis; Benzamides; Buthionine Sulfoximine; Cadmium; Caspase 3; Caspase 9; Caspases; Drug Interactions; Glutathione; Humans; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Monocytes; Necrosis; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transfection; U937 Cells | 2006 |
Direct measurement of the rate of glutathione synthesis in 1-chloro-2,4-dinitrobenzene treated human erythrocytes.
Topics: Acetylcysteine; Buthionine Sulfoximine; Dinitrochlorobenzene; Erythrocytes; Glucose; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Synthase; Glutathione Transferase; Hemolysis; Humans; Methemoglobin; Oxidation-Reduction | 2006 |
Evidence of a new dechlorinated ochratoxin A derivative formed in opossum kidney cell cultures after pretreatment by modulators of glutathione pathways: correlation with DNA-adduct formation.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Chlorine; Chromatography, High Pressure Liquid; DNA Adducts; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Glutathione Synthase; Isoxazoles; Kidney; Mesna; Ochratoxins; Opossums; Oxidative Stress; Spectrometry, Mass, Electrospray Ionization | 2006 |
Up-regulation of P-glycoprotein expression by glutathione depletion-induced oxidative stress in rat brain microvessel endothelial cells.
Topics: Acetylcysteine; Animals; Animals, Newborn; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brain; Buthionine Sulfoximine; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Oxidative Stress; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Tetrazolium Salts; Thiazoles; Time Factors; Up-Regulation | 2006 |
Multidrug resistance related protein (ABCC1) and its role on nitrite production by the murine macrophage cell line RAW 264.7.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutathione; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Multidrug Resistance-Associated Proteins; Nitric Oxide Synthase Type II; Nitrites | 2007 |
2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Catalase; Cell Growth Processes; Cisplatin; Deoxyglucose; Drug Synergism; Glutathione; Head and Neck Neoplasms; Humans; Oxidative Stress; Polyethylene Glycols; Superoxide Dismutase | 2007 |
Manipulation of energy and redox states in the C6 glioma cells by buthionine sulfoxamine and N-acetylcysteine and the effect on cell survival to cadmium toxicity.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cadmium; Cell Line, Tumor; Cell Survival; Energy Metabolism; Glutathione; Glutathione Disulfide; Humans; Oxidation-Reduction; Rats | 2007 |
Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.
Topics: Acetylcysteine; Amino Acid Sequence; Binding Sites; Buthionine Sulfoximine; Camptothecin; Cell Line, Tumor; Cross-Linking Reagents; Cysteine; Diamide; DNA Damage; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutaral; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Models, Molecular; Oxidative Stress; Phosphorylation; Recombinant Proteins; Tandem Mass Spectrometry; tert-Butylhydroperoxide; Tumor Suppressor Protein p53 | 2007 |
Novel use of the fluorescent dye 5-(and-6)-chloromethyl SNARF-1 acetate for the measurement of intracellular glutathione in leukemic cells and primary lymphocytes.
Topics: Acetylcysteine; Benzopyrans; Buthionine Sulfoximine; Cell Line, Tumor; Diamide; Flow Cytometry; Fluorescent Dyes; Glutathione; Humans; Jurkat Cells; Lymphocytes; Naphthols; Rhodamines | 2007 |
Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice.
Topics: Acetylcysteine; Activating Transcription Factor 2; Animals; Antioxidants; Brain; Butadienes; Buthionine Sulfoximine; Glutathione; Imidazoles; Kidney; Liver; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; NF-kappa B; Nitriles; Oxidative Stress; Proto-Oncogene Proteins c-jun; Pyridines; Reactive Oxygen Species; Sulfhydryl Compounds | 2007 |
Glucose-6-phosphate dehydrogenase plays a central role in modulating reduced glutathione levels in reed callus under salt stress.
Topics: Acetylcysteine; Adaptation, Physiological; Blotting, Western; Buthionine Sulfoximine; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Peroxide; Intracellular Space; Ions; Poaceae; Salinity; Sodium Chloride; Wetlands | 2008 |
Supplementation with antioxidants fails to increase the total antioxidant capacity of several cell lines in culture.
Topics: Acetylcysteine; Antimetabolites; Antioxidants; Ascorbic Acid; Buthionine Sulfoximine; Cell Line; Chromatography, High Pressure Liquid; Electrochemistry; Ferric Compounds; Free Radical Scavengers; Glutathione; Humans; Keratinocytes; Proteins; Reactive Oxygen Species; Uric Acid | 2008 |
Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Carrier Proteins; Embryo, Nonmammalian; Ferritins; Fullerenes; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione Transferase; HSP70 Heat-Shock Proteins; Hydrogen Peroxide; Light; Maleates; Microarray Analysis; Models, Animal; Oxidative Stress; Pericardial Effusion; Time Factors; Zebrafish | 2008 |
Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts.
Topics: Acetylcysteine; Antimetabolites; Biomarkers; Buthionine Sulfoximine; Carcinogens, Environmental; Chromium; Dactinomycin; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Glutathione; Heme Oxygenase-1; Humans; Microarray Analysis; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; Skin | 2008 |
15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism.
Topics: Acetylcysteine; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Free Radical Scavengers; Glutathione; Humans; Mesangial Cells; PPAR gamma; Prostaglandin D2; Prostaglandins A; Reactive Oxygen Species; Sulfhydryl Compounds; Up-Regulation | 2008 |
Increased metal tolerance in Salix by nicotinamide and nicotinic acid.
Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Buthionine Sulfoximine; Cadmium; Chromatography, High Pressure Liquid; Copper; Enzyme Inhibitors; Glutathione; Metals; Niacin; Niacinamide; Pyrrolidonecarboxylic Acid; Salix; Thiazolidines; Zinc | 2008 |
Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic beta-cells.
Topics: Acetylcysteine; Aldehydes; Amino Acid Transport System y+; Animals; Animals, Newborn; Biological Transport; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine; Fibroblasts; Gene Expression; Glutathione; Homeodomain Proteins; Humans; Hydrogen Peroxide; Insulin-Secreting Cells; Kinetics; Oxidative Stress; Protein Transport; Rats; Rats, Wistar; Trans-Activators | 2008 |
Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Brefeldin A; Buthionine Sulfoximine; DNA-Binding Proteins; Enzyme Inhibitors; Free Radical Scavengers; Humans; JNK Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Regulatory Factor X Transcription Factors; Response Elements; Transcription Factor CHOP; Transcription Factors; Up-Regulation; X-Box Binding Protein 1 | 2008 |
Boric acid inhibits LPS-induced TNF-alpha formation through a thiol-dependent mechanism in THP-1 cells.
Topics: Acetylcysteine; Boric Acids; Buthionine Sulfoximine; Cell Line; Gene Expression Regulation; Glutathione; Humans; Lipopolysaccharides; Monocytes; RNA, Messenger; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha | 2008 |
A reducing environment stabilizes HIF-2alpha in SH-SY5Y cells under hypoxic conditions.
Topics: Acetylcysteine; Basic Helix-Loop-Helix Transcription Factors; Buthionine Sulfoximine; Catalase; Cell Hypoxia; Cell Line, Tumor; Free Radical Scavengers; Humans; Hydrogen Peroxide; Oxidation-Reduction; Superoxide Dismutase; Superoxide Dismutase-1 | 2008 |
Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Therapy, Combination; Glutathione; Head and Neck Neoplasms; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Sulfhydryl Compounds; Zidovudine | 2009 |
Early sensing and gene expression profiling under a low dose of cadmium exposure.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Cadmium; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Gene Expression Profiling; Hepatocytes; Male; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors | 2009 |
The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Cytoprotection; Glutamate-Cysteine Ligase; Glutathione; Mercuric Chloride; Mercury Poisoning; Mice; Neuroblastoma; Sulfhydryl Compounds | 2009 |
Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Drug Synergism; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Oxidative Stress; Radiation Tolerance; Sulfhydryl Compounds; Thiocarbamates; X-Rays | 2009 |
Nrf2 is involved in inhibiting Tat-induced HIV-1 long terminal repeat transactivation.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Buthionine Sulfoximine; Cell Nucleus; Enzyme Inhibitors; Gene Expression Regulation, Viral; Glutathione; HeLa Cells; HIV Infections; HIV-1; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Reactive Oxygen Species; RNA, Small Interfering; tat Gene Products, Human Immunodeficiency Virus; Terminal Repeat Sequences; Transcriptional Activation; Virus Replication | 2009 |
Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Buthionine Sulfoximine; Cadmium Chloride; Cell Line; Cell Survival; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Glutathione; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Retinal Pigment Epithelium; Time Factors | 2009 |
Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities.
Topics: Acetylcysteine; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line, Tumor; Chromatography, High Pressure Liquid; Curcumin; Flow Cytometry; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Pyrazoles; Structure-Activity Relationship | 2009 |
The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione.
Topics: Acetylcysteine; Adenocarcinoma; Amitrole; Antimycin A; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2009 |
Effect of N-acetylcysteine on sympathetic hyperinnervation in post-infarcted rat hearts.
Topics: Acetylcysteine; Animals; Arrhythmias, Cardiac; Buthionine Sulfoximine; Echocardiography; Fluorescent Antibody Technique; Glutathione; Heart; Male; Myocardial Infarction; Nerve Growth Factor; Norepinephrine; Rats; Rats, Wistar; Sympathetic Nervous System | 2010 |
Reactive oxygen species and glutathione level changes by a proteasome inhibitor, MG132, partially affect calf pulmonary arterial endothelial cell death.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cattle; Cell Culture Techniques; Cell Death; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Glutathione; Humans; Leupeptins; Membrane Potential, Mitochondrial; Proteasome Inhibitors; Pulmonary Artery; Reactive Oxygen Species | 2010 |
The changes of reactive oxygen species and glutathione by MG132, a proteasome inhibitor affect As4.1 juxtaglomerular cell growth and death.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspase 8; Cell Line, Tumor; Ditiocarb; Enzyme Inhibitors; G1 Phase; Glutathione; Juxtaglomerular Apparatus; Leupeptins; Membrane Potential, Mitochondrial; Mice; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2010 |
The effects of N-acetyl cysteine on the MG132 proteasome inhibitor-treated lung cancer cells in relation to cell growth, reactive oxygen species and glutathione.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Leupeptins; Lung Neoplasms; Membrane Potential, Mitochondrial; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species | 2010 |
Glutathione synthesis inhibitor butathione sulfoximine regulates ceruloplasmin by dual but opposite mechanism: Implication in hepatic iron overload.
Topics: 3' Untranslated Regions; Acetylcysteine; Buthionine Sulfoximine; Ceruloplasmin; Glutathione; Hep G2 Cells; Humans; Iron; Iron Overload; Liver; RNA, Messenger | 2010 |
The effects of antimycin A on endothelial cells in cell death, reactive oxygen species and GSH levels.
Topics: Acetylcysteine; Animals; Antimycin A; Apoptosis; Buthionine Sulfoximine; Caspase Inhibitors; Cell Line; Endothelial Cells; Enzyme Inhibitors; Glutathione; Humans; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2010 |
Spinal levels of nonprotein thiols are related to nociception in mice.
Topics: Acetylcysteine; Acute Disease; Analgesics; Animals; Antimetabolites; Arthritis, Experimental; Behavior, Animal; Buthionine Sulfoximine; Capsaicin; Disease Models, Animal; Female; Foot Injuries; Lipid Peroxidation; Lumbar Vertebrae; Male; Mice; Oxidative Stress; Pain; Spinal Cord; Sulfhydryl Compounds | 2010 |
Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase.
Topics: Acetylcysteine; Antineoplastic Agents; Ascorbic Acid; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Cell Proliferation; Gallic Acid; Glutathione; Humans; Lung Neoplasms; Oxidative Stress; Reactive Oxygen Species | 2010 |
Tissue-specific effects of fenthion on glutathione metabolism modulated by NAC and BSO in Oreochromis niloticus.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cichlids; Fenthion; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Insecticides; Kidney; Liver; Organ Specificity; Oxidation-Reduction; Toxicity Tests | 2010 |
Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; Glutathione; Humans; Lipid Peroxidation; Lung; Membrane Lipids; Nanoparticles; Oxidants; Oxidative Stress; Particle Size; Reactive Oxygen Species; Silicon Dioxide | 2010 |
Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Colonic Neoplasms; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Oligopeptides; Oxidative Stress; Polyisoprenyl Phosphates; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Simvastatin | 2010 |
The role of intracellular glutathione in the progression of Chlamydia trachomatis infection.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Survival; Chlamydia Infections; Chlamydia trachomatis; Glutathione; Glutathione Disulfide; HeLa Cells; Humans; Hydrogen Peroxide; Inclusion Bodies; Proteome | 2010 |
Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model.
Topics: Acetylcysteine; Biomarkers; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamate-Cysteine Ligase; Humans; Hydrogen Peroxide; Matrix Metalloproteinase 2; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Time Factors; Ubiquinone | 2010 |
Fluoride-induced genotoxicity in mouse bone marrow cells: effect of buthionine sulfoximine and N-acetyl-L-cysteine.
Topics: Acetylcysteine; Animals; Annexin A5; Apoptosis; Bone Marrow Cells; Buthionine Sulfoximine; Cell Cycle; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Glutathione; Male; Mice; Reactive Oxygen Species; Sodium Fluoride | 2011 |
In vivo inhibition of l-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Cataract; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lens, Crystalline; Male; Malondialdehyde; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar | 2011 |
Low-dose methylmercury-induced oxidative stress, cytotoxicity, and tau-hyperphosphorylation in human neuroblastoma (SH-SY5Y) cells.
Topics: Acetylcysteine; Antioxidants; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Dipeptides; Glutathione; Humans; Methylmercury Compounds; Mitochondria; Neuroblastoma; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; tau Proteins | 2012 |
Intracellular glutathione levels are involved in carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone-induced apoptosis in As4.1 juxtaglomerular cells.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Catalase; Cell Death; Cell Line; Glutathione; Intracellular Space; Juxtaglomerular Apparatus; Mice; Mitochondria; Reactive Oxygen Species; Superoxide Dismutase | 2011 |
Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Glutathione; Glutathione Transferase; Humans; Lung Neoplasms; Microscopy, Fluorescence; Organoselenium Compounds; Oxidative Stress; Reactive Oxygen Species | 2012 |
Selective toxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells is potentially attributed to downregulation of glutathione.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Acetylcysteine; Animals; Anti-Inflammatory Agents; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Free Radical Scavengers; Glutathione; Glycyrrhetinic Acid; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Neoplasms; Oxidation-Reduction; Protein Binding; Protein Conformation; Reactive Oxygen Species; Up-Regulation | 2011 |
A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium.
Topics: Acetylcysteine; Alveolar Epithelial Cells; Buthionine Sulfoximine; Cells, Cultured; Enzyme Activation; Glutamate-Cysteine Ligase; Glutathione Disulfide; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; MAP Kinase Signaling System; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Alveoli; Pyridines; Tumor Necrosis Factor-alpha | 2011 |
Inhibition of cyclooxygenase-2 and inducible nitric oxide synthase by silymarin in proliferating mesenchymal stem cells: comparison with glutathione modifiers.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Hydrogen Peroxide; Mesenchymal Stem Cells; Nitric Oxide Synthase Type II; Silymarin; Time Factors | 2012 |
Oxidative state and IL-6 production in intestinal myofibroblasts of Crohn's disease patients.
Topics: Acetylcysteine; Adult; Buthionine Sulfoximine; Cell Line; Colon; Crohn Disease; Female; Glutathione; Glutathione Disulfide; Humans; Ileum; Interleukin-6; Lipopolysaccharides; Male; Middle Aged; Mitogen-Activated Protein Kinase 3; Myofibroblasts; N-Formylmethionine Leucyl-Phenylalanine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.
Topics: Acetylcysteine; Aged; Aldehydes; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cell Line, Tumor; ErbB Receptors; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione Transferase; Humans; Immunohistochemistry; Male; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tyrphostins | 2011 |
Intracellular GSH and ascorbate inhibit radical-induced protein chain peroxidation in HL-60 cells.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Buthionine Sulfoximine; Cell Survival; Gamma Rays; Glutamate-Cysteine Ligase; Glutathione; HL-60 Cells; Humans; Hydrogen Peroxide; Oxidants; Oxidation-Reduction; Oxidative Stress; Proteins; Superoxides | 2012 |
Effects of inorganic and organic arsenic compounds on growth and apoptosis of human T-lymphoblastoid leukemia cells.
Topics: Acetylcysteine; Apoptosis; Arsenic; Ascorbic Acid; Benzimidazoles; Buthionine Sulfoximine; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Female; Humans; Inhibitory Concentration 50; Leukemia, T-Cell; Leukocytes, Mononuclear; Models, Chemical; Organic Chemicals; T-Lymphocytes; Tetrazolium Salts; Thiazoles | 2011 |
TRPM2 channel protective properties of N-acetylcysteine on cytosolic glutathione depletion dependent oxidative stress and Ca2+ influx in rat dorsal root ganglion.
Topics: Acetylcysteine; Animals; Boron Compounds; Buthionine Sulfoximine; Calcium; Enzyme Inhibitors; Free Radical Scavengers; Ganglia, Spinal; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; In Vitro Techniques; Lipid Peroxidation; Male; Membrane Potentials; Neurons; Oxidants; Oxidative Stress; Rats; Rats, Wistar; TRPM Cation Channels | 2012 |
Reactive oxygen species regulate the replication of porcine circovirus type 2 via NF-κB pathway.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Circoviridae Infections; Circovirus; NF-kappa B; Reactive Oxygen Species; Swine; Swine Diseases; Virus Replication | 2012 |
Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells.
Topics: Acetylcysteine; Aconitate Hydratase; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Biomarkers; Buthionine Sulfoximine; Caspase 3; Cell Respiration; DNA Fragmentation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Glutathione; Glutathione Transferase; Hep G2 Cells; Humans; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Reactive Oxygen Species | 2012 |
MMPT as a reactive oxygen species generator induces apoptosis via the depletion of intracellular GSH contents in A549 cells.
Topics: Acetylcysteine; Aniline Compounds; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Cell Survival; G2 Phase Cell Cycle Checkpoints; Glutathione; Humans; Intracellular Space; M Phase Cell Cycle Checkpoints; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Thiazoles | 2012 |
Involvement of reactive oxygen species and glutathione in gallic acid-induced human umbilical vein endothelial cell death.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Death; Cell Proliferation; Cells, Cultured; Gallic Acid; Glutathione; Human Umbilical Vein Endothelial Cells; Humans; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2012 |
Arsenic trioxide induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Fibroblasts; Glutathione; Humans; Lung; Oxides; Reactive Oxygen Species; Transfection | 2012 |
Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling.
Topics: Acetylcysteine; Animals; Bone Morphogenetic Protein 2; Buthionine Sulfoximine; Cell Differentiation; Cell Line; Fibroblast Growth Factor 2; Glutathione; Humans; MAP Kinase Kinase 6; Neurites; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species; Signal Transduction; Smad Proteins; Stem Cells; Up-Regulation | 2012 |
Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Janus Kinase 1; Leukemia Inhibitory Factor; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Protein Binding; Rats; Rats, Sprague-Dawley; STAT1 Transcription Factor; STAT3 Transcription Factor | 2012 |
Immunoregulatory effects of glutathione during mesenchymal stem cell differentiation to hepatocyte-like cells.
Topics: Acetylcysteine; Bone Marrow Cells; Buthionine Sulfoximine; Cell Differentiation; Cells, Cultured; Cytokines; Glutathione; Guided Tissue Regeneration; Hepatocytes; Humans; Immunomodulation; Inflammation Mediators; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Reactive Oxygen Species | 2012 |
Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response.
Topics: Acetylcysteine; Amino Acid Substitution; Buthionine Sulfoximine; Cell Adhesion Molecules; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Extracellular Matrix Proteins; Free Radical Scavengers; HEK293 Cells; Humans; Membrane Glycoproteins; Mutation, Missense; Oxidation-Reduction; Oxidoreductases; Unfolded Protein Response | 2012 |
Implication of glutathione in the in vitro antiplasmodial mechanism of action of ellagic acid.
Topics: Acetylcysteine; Animals; Antimalarials; Antioxidants; Ascorbic Acid; Buthionine Sulfoximine; Cells, Cultured; Deferoxamine; Drug Synergism; Ellagic Acid; Enzyme Inhibitors; Erythrocytes; Glutathione; Humans; Inhibitory Concentration 50; Mice; Oxidation-Reduction; Plasmodium falciparum; Plasmodium yoelii; Reactive Oxygen Species; Siderophores | 2012 |
Role of GSH/GSSG redox couple in osteogenic activity and osteoclastogenic markers of human osteoblast-like SaOS-2 cells.
Topics: Acetylcysteine; Biomarkers, Tumor; Blotting, Western; Buthionine Sulfoximine; Cell Differentiation; Cell Line, Tumor; Core Binding Factor Alpha 1 Subunit; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Humans; Osteoblasts; Osteoclasts; Osteogenesis; Osteoprotegerin; Oxidation-Reduction; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction | 2013 |
Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Buthionine Sulfoximine; Cell Death; Cell Differentiation; Cell Line, Tumor; Dipeptides; Dopaminergic Neurons; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperazines | 2013 |
Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy.
Topics: Acetylcysteine; Adenosine Triphosphate; Adrenoleukodystrophy; Age Factors; Analysis of Variance; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Brain; Buthionine Sulfoximine; Cell Death; Chromatin; Cyclophilins; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Galactose; Gene Expression Regulation; Glucose; Glutathione; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Neuroprotective Agents; Oligopeptides; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Permeability; Reactive Oxygen Species; Thioctic Acid; Time Factors; Tubulin; Vitamin E | 2012 |
Suberoyl bishydroxamic acid-induced apoptosis in HeLa cells via ROS-independent, GSH-dependent manner.
Topics: Acetylcysteine; Apoptosis; Ascorbic Acid; Buthionine Sulfoximine; Caspase Inhibitors; Cell Proliferation; Glutathione; HeLa Cells; Histone Deacetylases; Humans; Hydroxamic Acids; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2013 |
Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn's disease patients.
Topics: Acetylcysteine; Adult; Buthionine Sulfoximine; Crohn Disease; Enzyme Activation; Glutathione; Glutathione Disulfide; Humans; Intestines; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Middle Aged; Mitogen-Activated Protein Kinases; Myofibroblasts; Oxidation-Reduction; Phosphorylation; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha; Young Adult | 2013 |
Neuroprotection induced by N-acetylcysteine against cytosolic glutathione depletion-induced Ca2+ influx in dorsal root ganglion neurons of mice: role of TRPV1 channels.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Calcium Signaling; Capsaicin; Caspase 3; Caspase 9; Cell Survival; Cells, Cultured; Cytosol; Drug Interactions; Ganglia, Spinal; Glutathione; Lipid Peroxidation; Male; Membrane Potentials; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; TRPV Cation Channels | 2013 |
Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Proliferation; Cell Survival; Diterpenes, Kaurane; Glutathione; Glutathione Peroxidase; Glutathione Reductase; HL-60 Cells; Humans; Reactive Oxygen Species | 2013 |
Curcumin sensitizes lung adenocarcinoma cells to apoptosis via intracellular redox status mediated pathway.
Topics: Acetylcysteine; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Buthionine Sulfoximine; Caspase 3; Cell Line, Tumor; Curcumin; Drug Screening Assays, Antitumor; Enzyme Activation; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Humans; Lipid Peroxidation; Lung Neoplasms; MAP Kinase Signaling System; Oxidants; Oxidation-Reduction; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Messenger; RNA, Neoplasm; Superoxides | 2012 |
Deferoxamine promotes osteoblastic differentiation in human periodontal ligament cells via the nuclear factor erythroid 2-related factor-mediated antioxidant signaling pathway.
Topics: Acetylcysteine; Antioxidant Response Elements; Buthionine Sulfoximine; Calcification, Physiologic; Calcium; Cell Differentiation; Cell Line; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Humans; Maleates; MAP Kinase Signaling System; NF-E2-Related Factor 2; NF-kappa B; Osteoblasts; Periodontal Ligament; Reactive Oxygen Species; RNA, Small Interfering; Siderophores; Signal Transduction; Vitamin E | 2014 |
Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells.
Topics: Acetylcysteine; Animals; Brain Neoplasms; Buthionine Sulfoximine; Cell Differentiation; Down-Regulation; Forkhead Box Protein O3; Forkhead Transcription Factors; Glioma; Humans; Hydrogen Peroxide; Imidazoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase 7; Neoplastic Stem Cells; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; RNA Interference; Transplantation, Heterologous | 2014 |
Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: effect of N-acetylcysteine and curcumin.
Topics: Acetylcysteine; Adult; Anti-Inflammatory Agents; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Colon; Crohn Disease; Curcumin; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Intestinal Mucosa; Matrix Metalloproteinase 3; Middle Aged; Myofibroblasts; Oxidation-Reduction; Oxidative Stress; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha; Up-Regulation; Young Adult | 2014 |
GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose.
Topics: Acetylcysteine; Alcohol Dehydrogenase; Antimetabolites; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Survival; Clone Cells; Cytochrome P-450 CYP2E1; Glucose; Glutathione; Hep G2 Cells; Hepatocytes; Humans; Hyperglycemia; Lactoylglutathione Lyase; Maleates; Oxidative Stress; Reactive Oxygen Species; Recombinant Proteins; Ursodeoxycholic Acid | 2015 |
Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Auranofin; Buthionine Sulfoximine; Caspase Inhibitors; Cell Proliferation; Glutathione; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Necrosis; Oligopeptides; Oxidative Stress; Singlet Oxygen | 2015 |
Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Benzylisoquinolines; Buthionine Sulfoximine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Glutathione; Hep G2 Cells; Humans; Indolequinones; Ketoconazole; Kinetics; Madin Darby Canine Kidney Cells; Microsomes, Liver; Troleandomycin | 2014 |
High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature.
Topics: Acetylcysteine; Animals; Brain; Buthionine Sulfoximine; Cell Line; Diabetes Mellitus, Experimental; Endothelial Cells; Free Radical Scavengers; Glucose; Glutathione; Glycosylation; Humans; Lactoylglutathione Lyase; Male; Microvessels; Occludin; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Wistar; Thiolester Hydrolases | 2015 |
Oxidative DNA damage induced by di-(2-ethylhexyl) phthalate in HEK-293 cell line.
Topics: Acetylcysteine; Buthionine Sulfoximine; Diethylhexyl Phthalate; DNA Damage; Glutathione; HEK293 Cells; Humans; Lysosomes; Mitochondria; Oxidative Stress; Plasticizers | 2015 |
Differential in vivo genotoxicity of arsenic trioxide in glutathione depleted mouse bone marrow cells: expressions of Nrf2/Keap1/P62.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Arsenic Trioxide; Arsenicals; Bone Marrow Cells; Buthionine Sulfoximine; Chromatids; Chromosome Aberrations; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Glutathione; Kelch-Like ECH-Associated Protein 1; Male; Membrane Glycoproteins; Mice; Mutagens; Neoplasm Proteins; NF-E2-Related Factor 2; Nuclear Pore Complex Proteins; Oxides | 2015 |
Auranofin-induced oxidative stress causes redistribution of the glutathione pool in Taenia crassiceps cysticerci.
Topics: Acetylcysteine; Animals; Antioxidants; Auranofin; Buthionine Sulfoximine; Cysticercus; Glutathione; Oxidants; Oxidative Stress; Reactive Oxygen Species; Survival Analysis; Taenia | 2015 |
Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.
Topics: Acetylcysteine; Animals; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; CD36 Antigens; Cell Line; Free Radical Scavengers; Gene Expression; Glutathione; Glutathione Disulfide; Lipoproteins, LDL; Macrophages; Mice, Inbred C57BL; Mice, Knockout; PPAR gamma; Protein Biosynthesis; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2015 |
N-acetylcysteine stimulates protein synthesis in enterocytes independently of glutathione synthesis.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Cell Proliferation; Cysteine; Enterocytes; Eukaryotic Initiation Factors; Glutathione; Maleates; Protein Biosynthesis; Real-Time Polymerase Chain Reaction; Sus scrofa; TOR Serine-Threonine Kinases | 2016 |
Resveratrol attenuates monocyte-to-macrophage differentiation and associated inflammation via modulation of intracellular GSH homeostasis: Relevance in atherosclerosis.
Topics: Acetylcysteine; AMP-Activated Protein Kinases; Animals; Antioxidants; Apolipoproteins E; Atherosclerosis; Buthionine Sulfoximine; Cell Differentiation; Glutathione; Homeostasis; Humans; Inflammation; Macrophages; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Monocytes; Resveratrol; Stilbenes; Tetradecanoylphorbol Acetate | 2016 |
Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.
Topics: Acetylcysteine; Adenosine Triphosphate; Aldehydes; Animals; Apoptosis; Buthionine Sulfoximine; Catalase; CCAAT-Enhancer-Binding Protein-delta; DNA; DNA Breaks, Double-Stranded; Dose-Response Relationship, Radiation; Embryo, Mammalian; Fibroblasts; Gamma Rays; Gene Expression Regulation; Glutathione; Mice; Mice, Knockout; Mitochondria; Oxidative Stress; Polyethylene Glycols; Primary Cell Culture; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2016 |
Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; Catalase; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glutathione; Humans; Hydrogen Peroxide; Lipid Peroxidation; Neuroblastoma; Topoisomerase II Inhibitors; Up-Regulation | 2016 |
Nanotoxicity of cobalt induced by oxidant generation and glutathione depletion in MCF-7 cells.
Topics: Acetylcysteine; Antioxidants; Buthionine Sulfoximine; Caspase 3; Cell Survival; Cobalt; Glutathione; Humans; Lipid Peroxidation; MCF-7 Cells; Membrane Potential, Mitochondrial; Metal Nanoparticles; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Oxidative Stress; Reactive Oxygen Species; Solubility; X-Ray Diffraction | 2017 |
Gallic acid induces HeLa cell death via increasing GSH depletion rather than ROS levels.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Death; Gallic Acid; Glutathione; HeLa Cells; Human Umbilical Vein Endothelial Cells; Humans; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2017 |
Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase.
Topics: Acetylcysteine; Aminoquinolines; Animals; Antioxidants; Buthionine Sulfoximine; Disease Models, Animal; Humans; Imiquimod; Inflammation; Kidney; Kidney Diseases; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Psoriasis | 2017 |
Suberoylanilide hydroxamic acid induces thioredoxin1-mediated apoptosis in lung cancer cells via up-regulation of miR-129-5p.
Topics: 3' Untranslated Regions; A549 Cells; Acetylcysteine; Apoptosis; Blotting, Western; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutathione; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; MicroRNAs; Reactive Oxygen Species; Thioredoxins; Up-Regulation; Vorinostat | 2017 |
Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress.
Topics: Acetylcysteine; Animals; Antimetabolites; Brain; Buthionine Sulfoximine; Cytokines; Enzyme-Linked Immunosorbent Assay; Ethanol; Female; Fetus; Free Radical Scavengers; Glutathione; Inflammation; Male; Mice; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; RNA, Messenger | 2017 |
Effect of bleaching agent extracts on murine macrophages.
Topics: Acetylcysteine; Animals; Antigens, Surface; Bleaching Agents; Buthionine Sulfoximine; Carbamide Peroxide; Cell Survival; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hydrogen Peroxide; Macrophages; Mice; Peroxides; Tooth Bleaching; Tumor Necrosis Factor-alpha; Urea | 2018 |
Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cell Hypoxia; Cells, Cultured; Gene Knockout Techniques; Hematopoietic Stem Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; NF-kappa B; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2019 |
N-acetyl-cysteine blunts 6-hydroxydopamine- and L-buthionine-sulfoximine-induced apoptosis in human mesenchymal stromal cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Death; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mesenchymal Stem Cells; Oxidation-Reduction; Oxidative Stress; Oxidopamine; Reactive Oxygen Species | 2019 |
N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis.
Topics: Acetylcysteine; Animals; Basolateral Nuclear Complex; Buthionine Sulfoximine; Conditioning, Classical; Cues; Dithiothreitol; Extinction, Psychological; Fear; Glutathione; Homeostasis; Male; Memory; Rats; Rats, Sprague-Dawley | 2022 |
Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Chemokine CCL7; Cytokines; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Eye; Glutamate-Cysteine Ligase; Immunity, Innate; Lens, Crystalline; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Reactive Oxygen Species; Up-Regulation | 2022 |
Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Auranofin; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2022 |
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Fibroblasts; Hepatocytes; Humans; Liver; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Wharton Jelly | 2022 |
Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Multidrug Resistance-Associated Proteins; Orphan Drug Production; Paclitaxel; RNA Stability; RNA, Messenger; Structure-Activity Relationship; Tiopronin | 2011 |
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Drug Discovery; Humans; Kelch-Like ECH-Associated Protein 1; Mice; NF-E2-Related Factor 2; Protein Binding | 2016 |