acetylcysteine and azathioprine

acetylcysteine has been researched along with azathioprine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (39.47)29.6817
2010's22 (57.89)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Ahmad, M; Al-Shabanah, OA; Gado, A; Raza, M1
Arriaza, E; Cara, C; Di Paola, M; Escribano, O; Fernández-Moreno, MD; Fueyo, JA; Guijarro, LG; Lorusso, M; Menor, C; Olleros, T; Román, ID1
Behr, J; Buhl, R; Capron, F; Corvasce, G; Costabel, U; De Vuyst, P; Dekhuijzen, R; Demedts, M; Flower, CD; Jansen, HM; Lankhorst, I; Laurent, F; MacNee, W; Montanari, M; Nicholson, AG; Petruzzelli, S; Rodriguez-Becerra, E; Sardina, M; Thomeer, M; van den Bosch, JM; Verbeken, EK; Verschakelen, J; Wallaert, B1
Hunninghake, GW1
Nathan, SD1
Wells, AU1
Eickelberg, O; Günther, A; Markart, P; Seeger, W1
Meng, Q; Shen, C; Wu, YT; Yin, J; Yu, JP1
Collard, HR; King, TE; Walter, N1
Bennett, L; Crouse, R; Feldstein, D1
Cottin, V2
Behr, J; Boissard, G; Buhl, R; Costabel, U; De Vuyst, P; Dekhuijzen, RP; Demedts, M; Flower, CD; Jansen, HM; Lankhorst, I; Laurent, F; MacNee, W; Nicholson, AG; Petruzzelli, S; Rodriguez-Becerra, E; Sardina, M; Thomeer, M; van den Bosch, JM; Verbeken, EK; Verschakelen, J; Wallaert, B1
Eckman, MH; Hagaman, JT; Kinder, BW1
Demedts, MG; Thomeer, M; Wuyts, WA1
Behr, J; Costabel, U; Worth, H1
McGrath, EE; Millar, AB1
Behr, J; Costabel, U; Cottin, V; Poletti, V; Wells, AU1
Anstrom, KJ; King, TE; Lasky, JA; Martinez, FJ; Raghu, G1
Behr, J1
Hanada, S; Kishi, K; Uruga, H1
Hirano, S; Iikura, M; Izumi, S1
Hashemi Sadraei, N; Masjedi, MR; Riahi, T1
Alfaro, TM; Cordeiro, CR; Freitas, S1
Ancochea, J; Valenzuela, C1
Anstrom, KJ; de Andrade, JA; King, TE; Martinez, FJ; Raghu, G1
Covvey, JR; Mancl, EE1
Aleksiejuk, P; Banki, K; Bonilla, E; Francis, L; Landas, SK; Liu, Y; Marchena-Mendez, I; Oaks, Z; Patel, J; Perl, A; Yu, J1
Álvarez-Sala Walther, R; Gómez Carrera, L1
Canestaro, WJ; Devine, BE; Forrester, SH; Ho, L; Raghu, G1
Banfield, L; Coyne, J; Cui, S; Guy, B; Helmeczi, W; Husnudinov, R; Jones, A; Khalid, MF; Kolb, MR; Mah, J; Pitre, T; Scallan, C; Su, J; Zeraatkar, D; Zhang, M1

Reviews

9 review(s) available for acetylcysteine and azathioprine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Therapeutic management of idiopathic pulmonary fibrosis: an evidence-based approach.
    Clinics in chest medicine, 2006, Volume: 27, Issue:1 Suppl 1

    Topics: Acetylcysteine; Azathioprine; Benzamides; Bosentan; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Humans; Imatinib Mesylate; Immunoglobulin G; Interferon-gamma; Piperazines; Prednisone; Pulmonary Fibrosis; Pyridones; Pyrimidines; Receptors, Tumor Necrosis Factor; Sulfonamides

2006
[Pulmonary fibrosis--a therapeutic dilemma?].
    Medizinische Klinik (Munich, Germany : 1983), 2006, Apr-15, Volume: 101, Issue:4

    Topics: Acetylcysteine; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Benzamides; Bosentan; Cyclophosphamide; Drug Therapy, Combination; Etanercept; Free Radical Scavengers; Humans; Imatinib Mesylate; Immunoglobulin G; Immunosuppressive Agents; Interferon-gamma; Lung Transplantation; Piperazines; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pyridones; Pyrimidines; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Sulfonamides

2006
Current perspectives on the treatment of idiopathic pulmonary fibrosis.
    Proceedings of the American Thoracic Society, 2006, Volume: 3, Issue:4

    Topics: Acetylcysteine; Anticoagulants; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Humans; Immunosuppressive Agents; Interferon-gamma; Lung Transplantation; Prednisone; Pulmonary Fibrosis; Pyridones; Quality of Life; Recombinant Proteins

2006
[Idiopathic interstitial pneumonia: treatment].
    Revue des maladies respiratoires, 2006, Volume: 23, Issue:4 Pt 2

    Topics: Acetylcysteine; Acute Disease; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Azathioprine; Benzamides; Bronchiolitis Obliterans; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colchicine; Cyclophosphamide; Diagnosis, Differential; Disease Progression; Female; Free Radical Scavengers; Humans; Imatinib Mesylate; Immunologic Factors; Immunosuppressive Agents; Lung Diseases, Interstitial; Male; Middle Aged; Piperazines; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pyrimidines; Randomized Controlled Trials as Topic; Retrospective Studies; Sex Factors

2006
Newer modes of treating interstitial lung disease.
    Current opinion in pulmonary medicine, 2011, Volume: 17, Issue:5

    Topics: Acetylcysteine; Adrenal Cortex Hormones; Azathioprine; Humans; Lung Diseases, Interstitial; Lung Transplantation; Palliative Care; Pyridones

2011
Recent evidence for pharmacological treatment of idiopathic pulmonary fibrosis.
    The Annals of pharmacotherapy, 2014, Volume: 48, Issue:12

    Topics: Acetylcysteine; Anti-Inflammatory Agents; Azathioprine; Humans; Idiopathic Pulmonary Fibrosis; Indoles; Prednisone; Pyridones; Randomized Controlled Trials as Topic

2014
Drug Treatment of Idiopathic Pulmonary Fibrosis: Systematic Review and Network Meta-Analysis.
    Chest, 2016, Volume: 149, Issue:3

    Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Azathioprine; Bayes Theorem; Bosentan; Endothelin Receptor Antagonists; Enzyme Inhibitors; Etanercept; Free Radical Scavengers; Humans; Idiopathic Pulmonary Fibrosis; Imatinib Mesylate; Immunosuppressive Agents; Indoles; Interferon-gamma; Phenylpropionates; Pyridazines; Pyridones; Pyrimidines; Recombinant Proteins; Sulfonamides; Vital Capacity; Warfarin

2016
Medical treatments for idiopathic pulmonary fibrosis: a systematic review and network meta-analysis.
    Thorax, 2022, Volume: 77, Issue:12

    Topics: Acetylcysteine; Adult; Azathioprine; Humans; Idiopathic Pulmonary Fibrosis; Network Meta-Analysis; Sildenafil Citrate

2022

Trials

6 trial(s) available for acetylcysteine and azathioprine

ArticleYear
High-dose acetylcysteine in idiopathic pulmonary fibrosis.
    The New England journal of medicine, 2005, Nov-24, Volume: 353, Issue:21

    Topics: Acetylcysteine; Aged; Anti-Inflammatory Agents; Antioxidants; Azathioprine; Double-Blind Method; Drug Therapy, Combination; Exercise Tolerance; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Prednisone; Pulmonary Diffusing Capacity; Pulmonary Fibrosis; Vital Capacity

2005
Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial.
    Respiratory research, 2009, Oct-27, Volume: 10

    Topics: Acetylcysteine; Aged; Azathioprine; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Europe; Exercise Test; Female; Forced Expiratory Volume; Humans; Idiopathic Pulmonary Fibrosis; Lung; Male; Middle Aged; Patient Dropouts; Prednisone; Pulmonary Diffusing Capacity; Respiratory System Agents; Severity of Illness Index; Time Factors; Treatment Outcome; Vital Capacity

2009
[Comments of the DGP on the press release dated 21.10. 2011 of the National Heart, Lung and Blood Institute about the PANTHER Study on IPF patients].
    Pneumologie (Stuttgart, Germany), 2011, Volume: 65, Issue:12

    Topics: Acetylcysteine; Aged; Aged, 80 and over; Azathioprine; Drug Therapy, Combination; Evidence-Based Medicine; Glucocorticoids; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Middle Aged; Placebos; Prednisolone; Randomized Controlled Trials as Topic; Respiratory System Agents; Treatment Outcome

2011
Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis.
    The New England journal of medicine, 2012, May-24, Volume: 366, Issue:21

    Topics: Acetylcysteine; Aged; Azathioprine; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Prednisone; Pulmonary Fibrosis; Treatment Outcome; Vital Capacity

2012
Treatment switching in idiopathic pulmonary fibrosis: from triple therapy to enrollment into a clinical investigational drug trial.
    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2013, Sep-01, Volume: 30 Suppl 1

    Topics: Acetylcysteine; Azathioprine; Double-Blind Method; Drugs, Investigational; Humans; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Treatment Outcome

2013
Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis.
    The New England journal of medicine, 2014, May-29, Volume: 370, Issue:22

    Topics: Acetylcysteine; Aged; Azathioprine; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Free Radical Scavengers; Humans; Idiopathic Pulmonary Fibrosis; Kaplan-Meier Estimate; Male; Middle Aged; Prednisone; Treatment Failure; Vital Capacity

2014

Other Studies

23 other study(ies) available for acetylcysteine and azathioprine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2003, Volume: 134, Issue:4

    Topics: Acetylcysteine; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Guanidines; Liver; Liver Diseases; Male; Rats; Rats, Wistar

2003
Azathioprine acts upon rat hepatocyte mitochondria and stress-activated protein kinases leading to necrosis: protective role of N-acetyl-L-cysteine.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Azathioprine; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA; DNA Fragmentation; Glutathione; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Male; Mitochondria, Liver; Mitogen-Activated Protein Kinase 3; Necrosis; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Stress, Physiological; Superoxides; Tetrazolium Salts; Thiazoles; Thymidine; Tritium

2004
Antioxidant therapy for idiopathic pulmonary fibrosis.
    The New England journal of medicine, 2005, Nov-24, Volume: 353, Issue:21

    Topics: Acetylcysteine; Anti-Inflammatory Agents; Antioxidants; Azathioprine; Drug Therapy, Combination; Glutathione; Humans; Lung; Prednisone; Pulmonary Fibrosis

2005
Antioxidant therapy in idiopathic pulmonary fibrosis: hope is kindled.
    The European respiratory journal, 2006, Volume: 27, Issue:4

    Topics: Acetylcysteine; Antioxidants; Azathioprine; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Humans; Prednisolone; Pulmonary Fibrosis

2006
Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:8

    Topics: Acetylcysteine; Animals; Azathioprine; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Glycyrrhiza; Glycyrrhizic Acid; Hepatocytes; Humans; Immunosuppressive Agents; Male; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Species Specificity

2006
Clinical use of evidence-based medicine--clinical questions: Acetylcysteine, a new treatment for an old foe?
    WMJ : official publication of the State Medical Society of Wisconsin, 2006, Volume: 105, Issue:6

    Topics: Acetylcysteine; Aged; Anti-Inflammatory Agents; Antioxidants; Azathioprine; Drug Therapy, Combination; Evidence-Based Medicine; Exercise Tolerance; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Prednisone; Pulmonary Diffusing Capacity; Pulmonary Fibrosis; Vital Capacity

2006
Thiopurine S- methyltransferase [corrected] testing in idiopathic pulmonary fibrosis: a pharmacogenetic cost-effectiveness analysis.
    Lung, 2010, Volume: 188, Issue:2

    Topics: Acetylcysteine; Azathioprine; Computer Simulation; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Drug Therapy, Combination; Gene Frequency; Genetic Testing; Genotype; Humans; Idiopathic Pulmonary Fibrosis; Leukopenia; Methyltransferases; Models, Economic; Patient Selection; Pharmacogenetics; Phenotype; Quality-Adjusted Life Years; Respiratory System Agents; Steroids; Treatment Outcome

2010
Hot off the breath: triple therapy for idiopathic pulmonary fibrosis--hear the PANTHER roar.
    Thorax, 2012, Volume: 67, Issue:2

    Topics: Acetylcysteine; Aged; Aged, 80 and over; Azathioprine; Drug Therapy, Combination; Evidence-Based Medicine; Glucocorticoids; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Middle Aged; Placebos; Prednisolone; Randomized Controlled Trials as Topic; Respiratory System Agents

2012
Triple therapy in idiopathic pulmonary fibrosis: an alarming press release.
    The European respiratory journal, 2012, Volume: 39, Issue:4

    Topics: Acetylcysteine; Azathioprine; Drug Therapy, Combination; Expectorants; Glucocorticoids; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Prednisolone

2012
Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis.
    The New England journal of medicine, 2012, 08-30, Volume: 367, Issue:9

    Topics: Acetylcysteine; Azathioprine; Female; Humans; Male; Prednisone; Pulmonary Fibrosis

2012
Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis.
    The New England journal of medicine, 2012, 08-30, Volume: 367, Issue:9

    Topics: Acetylcysteine; Azathioprine; Female; Humans; Male; Prednisone; Pulmonary Fibrosis

2012
Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis.
    The New England journal of medicine, 2012, 08-30, Volume: 367, Issue:9

    Topics: Acetylcysteine; Azathioprine; Female; Humans; Male; Prednisone; Pulmonary Fibrosis

2012
Idiopathic pulmonary fibrosis in a referral center in Iran: are patients developing the disease at a younger age?
    Archives of Iranian medicine, 2013, Volume: 16, Issue:3

    Topics: Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Age of Onset; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Azathioprine; Child; Drug Therapy, Combination; Expectorants; Female; Follow-Up Studies; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Iran; Kaplan-Meier Estimate; Male; Middle Aged; Retrospective Studies; Tertiary Care Centers; Treatment Outcome; Young Adult

2013
Clinical case: Differential diagnosis of idiopathic pulmonary fibrosis.
    BMC research notes, 2013, Volume: 6 Suppl 1

    Topics: Acetylcysteine; Alveolitis, Extrinsic Allergic; Azathioprine; Diagnosis, Differential; Disease Management; Humans; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Lung; Male; Middle Aged; Prednisolone; Pulmonary Emphysema; Radiography; Smoking

2013
Clinical case: Combined pulmonary fibrosis and emphysema with pulmonary hypertension--clinical management.
    BMC research notes, 2013, Volume: 6 Suppl 1

    Topics: Acetylcysteine; Azathioprine; Disease Management; Humans; Hypertension, Pulmonary; Lung; Male; Middle Aged; Oxygen Inhalation Therapy; Phenylpropionates; Prednisolone; Pulmonary Emphysema; Pulmonary Fibrosis; Pyridazines; Radiography; Smoking

2013
Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus.
    Clinical immunology (Orlando, Fla.), 2015, Volume: 160, Issue:2

    Topics: Acetylcysteine; Adult; Alanine Transaminase; Antibodies, Antinuclear; Aspartate Aminotransferases; Azathioprine; Biomarkers; Cohort Studies; Complement System Proteins; Cyclosporine; Diabetes Mellitus; Female; Free Radical Scavengers; Humans; Immunosuppressive Agents; Liver Diseases; Longitudinal Studies; Lupus Erythematosus, Systemic; Male; Middle Aged; Mycophenolic Acid; Prednisone; Prevalence; Retrospective Studies; Severity of Illness Index; Sex Distribution; Sirolimus

2015
[Pulmonary fibrosis].
    Medicina clinica, 2016, Feb-05, Volume: 146, Issue:3

    Topics: Acetylcysteine; Azathioprine; Clinical Trials as Topic; Forecasting; Glucocorticoids; Humans; Indoles; Multicenter Studies as Topic; Prognosis; Pulmonary Fibrosis; Pyridones

2016