acetylcysteine and arsenic trioxide

acetylcysteine has been researched along with arsenic trioxide in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.70)18.2507
2000's17 (45.95)29.6817
2010's19 (51.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dai, J; Jing, Y; Waxman, S; Weinberg, RS1
Bahlis, NJ; Boise, LH; Dalton, WS; Grad, JM; Oshiro, MM; Reis, I1
Bai, H; Lu, JH; Ou, YX; Wei, YM; Zheng, RL1
Chun, YJ; Hong, SI; Lee, HC; Lee, SH; Lee, SJ; Park, IC; Park, MJ; Rhee, CH; Woo, SH1
Bae, JH; Choi, YJ; Kim, SP; Kwon, TK; Mun, KC; Park, JW; Song, DK; Suh, SI1
Chaudhary, PM; Matta, H; Sun, Q1
Li, J; Shen, T; Zhang, ZN; Zuo, L1
Brannon, J; Dent, P; Fisher, PB; Gopalkrishnan, RV; Grant, S; Lebedeva, IV; Linehan, WM; McKinstry, R; Mitchell, C; Qiao, L; Rosenberg, E; Sarkar, D; Su, ZS; Valerie, K; Yacoub, A1
Aguilar, TM; Bahlis, NJ; Boise, LH; Krett, N; Lee, KP; McCafferty-Grad, J; Reis, I1
Chen, YB; Ding, SQ; Fu, WJ; Hou, J; Kong, XT; Wang, DX; Yuan, ZG1
Gao, F; Shi, GY; Tang, XM; Yi, J; Yuan, JQ1
Cao, EH; Qin, JF; Zhang, Y1
Han, ST; Kim, YH; Kwon, TK; Park, EJ; Park, JW1
Fu, Q; Hu, BR; Li, JJ; Li, Y; Ming, ZY; Qian, JQ; Tang, Q; Xiang, JZ1
Cai, J; Chen, Y; Hu, Q; Niu, X; Shi, G; Wang, J; Wu, H; Yi, J1
An, S; Choe, TB; Hong, SI; Jin, HO; Kim, ES; Kim, JI; Lee, HC; Lee, SJ; Park, IC; Rhee, CH; Seo, SK; Woo, SH; Yoo, DH1
Han, YH; Kim, SH; Kim, SZ; Park, WH1
Adachi, M; Wang, W; Zhang, R; Zhou, J; Zhu, D1
Altman, JK; Dolniak, B; Glaser, H; Goussetis, DJ; Kroczynska, B; McNeer, JL; Platanias, LC; Sassano, A1
Haller, E; Mills, GB; Nanjundan, M; Patel, S; Raffoul, F; Smith, DM1
An, Z; Huang, D; Liu, Y; Qi, Y; Zhang, W; Zhang, Y1
Chang, CF; Chen, YW; Cheng, PW; Ho, TJ; Huang, CF; Jinn, TR; Liu, SH; Lu, TH; Su, CC; Su, YC; Wu, CC; Yen, CC1
Chen, YA; Chiu, HW; Guo, HR; Ho, SY; Ho, YS; Wang, YJ; Wu, WJ1
Tang, X; Wang, C; Xiao, G; Yao, C1
Park, WH; You, BR1
Murray, E; Selvaraj, V; Yeager-Armstead, M1
Chan, SM; Feng, W; Huang, M; Li, MX; Majeti, R; Mitchell, BS; Thomas, D1
Choe, TB; Choi, HN; Hong, SI; Hwang, SG; Kim, JH; Lee, HG; Lee, YH; Park, IC; Seo, SK; Yi, JY1
Bhattacharya, S; Chakraborty, A; Chattopadhyay, A; Srivastava, R1
Lai, Y; Li, Y; Luo, Q; Zhang, Z1
Anselmo-Franci, JA; Barbosa Junior, F; Borges, Cdos S; da Silva, RF; Kempinas, Wde G; Kiguti, LR; Missassi, G; Pupo, AS; Villela E Silva, P1
Li, Y; Liu, J; Ma, X; Ye, BC; Zhang, B; Zuo, P1
Fu, R; Huang, L; Jiang, H; Li, L; Liu, Z1
Chao, L; Hu, L; Huang, R; Kang, Z; Li, Y; Ning, Z; Pan, J; Tang, Z; Wan, F; Wang, C; Yang, F; Zhong, G1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for acetylcysteine and arsenic trioxide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

36 other study(ies) available for acetylcysteine and arsenic trioxide

ArticleYear
Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system.
    Blood, 1999, Jan-01, Volume: 93, Issue:1

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Cells, Cultured; Drug Synergism; Glutathione; Growth Inhibitors; Hematopoietic Stem Cells; HL-60 Cells; Humans; Lymphoma; Mice; Mice, Inbred Strains; Oxidation-Reduction; Oxides; Tumor Cells, Cultured

1999
Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells.
    Blood, 2001, Aug-01, Volume: 98, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Cell Death; Drug Synergism; Glutathione; Humans; Hydrogen Peroxide; Multiple Myeloma; Oxides; Plasma Cells; Superoxides; Tumor Cells, Cultured

2001
Down-regulation of four arsenic antagonists on apoptosis and telomerase activity induced by arsenic trioxide in three myelocytic leukemia cell lines.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:8

    Topics: Acetylcysteine; Aminoquinolines; Antineoplastic Agents; Apoptosis; Arsenic; Arsenic Trioxide; Arsenicals; Catalase; Down-Regulation; HL-60 Cells; Humans; K562 Cells; Leukemia, Myeloid; Oxides; Telomerase

2001
Arsenic trioxide induces apoptosis through a reactive oxygen species-dependent pathway and loss of mitochondrial membrane potential in HeLa cells.
    International journal of oncology, 2002, Volume: 21, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Catalase; Dose-Response Relationship, Drug; Enzyme Activation; HeLa Cells; Humans; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Oxides; Reactive Oxygen Species; Signal Transduction

2002
Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxygen species and inhibition of Akt.
    International journal of oncology, 2002, Volume: 21, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Caspase Inhibitors; Caspases; Cytochrome c Group; Enzyme Activation; Humans; Oxides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; U937 Cells

2002
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.
    Blood, 2003, Mar-01, Volume: 101, Issue:5

    Topics: Acetylcysteine; Acute Disease; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Cell Transformation, Viral; Enzyme Activation; Gene Expression Regulation, Viral; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 8, Human; Humans; I-kappa B Proteins; Leukemia, Myeloid; Leupeptins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; NF-kappa B; Oxides; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Recombinant Proteins; Rhadinovirus; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Viral Proteins

2003
[The comparison between the mechanisms of sodium selenite induced apoptosis and arsenic trioxide induced apoptosis in human acute promyelocytic leukemia cell line NB4 cells].
    Zhongguo shi yan xue ye xue za zhi, 2002, Volume: 10, Issue:3

    Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Division; DNA, Neoplasm; Flow Cytometry; Glutathione; Humans; Intracellular Membranes; Leukemia, Promyelocytic, Acute; Membrane Potentials; Mitochondria; Oxides; Reactive Oxygen Species; Sodium Selenite; Tumor Cells, Cultured

2002
MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:7

    Topics: Acetylcysteine; Adenoviridae; Adjuvants, Immunologic; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Brain Neoplasms; Carcinoma, Renal Cell; Caspases; Cell Division; Free Radical Scavengers; Free Radicals; Genes, Tumor Suppressor; Glioma; Glutathione Transferase; Humans; Interleukins; Kidney; Kidney Neoplasms; Oxides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Receptors, Virus; Recombinant Fusion Proteins; Tumor Cells, Cultured

2003
Arsenic trioxide uses caspase-dependent and caspase-independent death pathways in myeloma cells.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:11

    Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase Inhibitors; Caspases; Drug Resistance, Neoplasm; Humans; Leukemia, Promyelocytic, Acute; Oxides; Plasma Cells; Superoxides; Tumor Cells, Cultured

2003
[Mechanism of arsenic trioxide-induced cytotoxicity on multiple myeloma cells].
    Ai zheng = Aizheng = Chinese journal of cancer, 2003, Volume: 22, Issue:12

    Topics: Acetylcysteine; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Division; Cell Survival; Drug Interactions; Glutathione; Humans; Multiple Myeloma; Oxides; Tumor Cells, Cultured; Vitamin K 3

2003
The cell cycle related apoptotic susceptibility to arsenic trioxide is associated with the level of reactive oxygen species.
    Cell research, 2004, Volume: 14, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Catalase; Cell Cycle; Cell Division; Cell Line, Tumor; Dactinomycin; Flow Cytometry; Fluoresceins; Humans; In Situ Nick-End Labeling; Interphase; Naphthoquinones; Oxides; Propidium; Reactive Oxygen Species

2004
Up-regulation of telomere-binding TRF1, TRF2 related to reactive oxygen species induced by As(2)O(3) in MGC-803 cells.
    European journal of pharmacology, 2005, May-23, Volume: 516, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Deoxyguanosine; Flow Cytometry; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Atomic Force; Oxides; Protein Binding; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomere; Telomeric Repeat Binding Protein 1; Telomeric Repeat Binding Protein 2; Tumor Suppressor Protein p53; Up-Regulation

2005
Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells.
    Life sciences, 2005, Oct-14, Volume: 77, Issue:22

    Topics: Acetylcysteine; Anthracenes; Arsenic Trioxide; Arsenicals; Blotting, Western; Cells, Cultured; DNA Primers; DNA-Binding Proteins; Gene Expression Regulation; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Luciferases; MAP Kinase Kinase 4; Oxides; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factors

2005
Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:8

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Free Radical Scavengers; Humans; Liver Neoplasms; Oxidative Stress; Oxides; Proto-Oncogene Proteins c-bcl-2

2006
Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:1

    Topics: Acetylcysteine; Actins; Anoikis; Arsenic Trioxide; Arsenicals; Carcinoma; Cell Line, Tumor; Emodin; Free Radical Scavengers; Humans; Oxidative Stress; Oxides; Protein Kinase Inhibitors; Reactive Oxygen Species; rhoA GTP-Binding Protein; Stomach Neoplasms; Transfection

2008
A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation.
    Lung cancer (Amsterdam, Netherlands), 2008, Volume: 61, Issue:3

    Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Drug Synergism; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxides; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sulindac

2008
Suppression of arsenic trioxide-induced apoptosis in HeLa cells by N-acetylcysteine.
    Molecules and cells, 2008, Jul-31, Volume: 26, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Catalase; Cell Cycle; Free Radical Scavengers; Glutathione; Growth Inhibitors; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Oxides; Reactive Oxygen Species; Superoxide Dismutase; Superoxides

2008
A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.
    Pancreas, 2009, Volume: 38, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Growth Inhibitors; Humans; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Oxides; Pancreatic Neoplasms; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays

2009
Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1.
    Molecular pharmacology, 2010, Volume: 77, Issue:5

    Topics: Acetylcysteine; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Dithiothreitol; Enzyme Activation; Genetic Variation; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Kinase Kinases; Oxides; Phosphorylation; Protein Kinases; Reactive Oxygen Species; RNA, Small Interfering; Tretinoin; U937 Cells

2010
Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells.
    Cell death and differentiation, 2010, Volume: 17, Issue:12

    Topics: Acetylcysteine; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Beclin-1; Carcinoma; Cell Line, Tumor; Female; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microtubule-Associated Proteins; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Oxides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta; Ubiquitin-Activating Enzymes

2010
Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:4

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Arsenic Trioxide; Arsenicals; DNA Damage; DNA, Mitochondrial; Female; Mice; Mitochondria; Oocytes; Oxidative Stress; Oxides; Reactive Oxygen Species

2011
Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway.
    Archives of toxicology, 2011, Volume: 85, Issue:6

    Topics: Acetylcysteine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Cerebral Cortex; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Environmental Pollutants; Gene Expression Regulation, Enzymologic; Glutathione; Glutathione Peroxidase; Lipid Peroxides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NAD(P)H Dehydrogenase (Quinone); Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Oxides; Random Allocation; RNA, Messenger

2011
Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways.
    Chemico-biological interactions, 2011, Sep-05, Volume: 193, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Cycle Proteins; Cell Survival; Cyclins; DNA Fragmentation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; F-Box Proteins; F-Box-WD Repeat-Containing Protein 7; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Models, Biological; Oxides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Tumor Stem Cell Assay; Ubiquitin-Protein Ligases; X-Rays

2011
Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione.
    Acta biochimica et biophysica Sinica, 2011, Volume: 43, Issue:9

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Glutathione; HL-60 Cells; Humans; Intracellular Space; Jurkat Cells; Leukemia; Mitochondria; Oxides; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; U937 Cells; X-Linked Inhibitor of Apoptosis Protein

2011
Arsenic trioxide induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion.
    Oncology reports, 2012, Volume: 28, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Fibroblasts; Glutathione; Humans; Lung; Oxides; Reactive Oxygen Species; Transfection

2012
Protective and antioxidant role of selenium on arsenic trioxide-induced oxidative stress and genotoxicity in the fish hepatoma cell line PLHC-1.
    Environmental toxicology and chemistry, 2012, Volume: 31, Issue:12

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Cell Line, Tumor; DNA Damage; Fishes; Free Radical Scavengers; Hazardous Substances; Membrane Potential, Mitochondrial; Mutagens; Oxidative Stress; Oxides; Reactive Oxygen Species; Selenium

2012
Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib.
    Leukemia, 2013, Volume: 27, Issue:10

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Nucleolus; Cell Proliferation; Cysteine; Cytosol; Drug Resistance, Neoplasm; Flow Cytometry; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Mutation; Nuclear Proteins; Nucleophosmin; Oxides; Pyrazines; Reactive Oxygen Species; Tryptophan; Tumor Cells, Cultured

2013
Knockdown of TWIST1 enhances arsenic trioxide- and ionizing radiation-induced cell death in lung cancer cells by promoting mitochondrial dysfunction.
    Biochemical and biophysical research communications, 2014, Jul-11, Volume: 449, Issue:4

    Topics: Acetylcysteine; Arsenic Trioxide; Arsenicals; Carcinoma, Non-Small-Cell Lung; Cell Death; Gene Knockdown Techniques; Humans; Membrane Potential, Mitochondrial; Nuclear Proteins; Oxides; Radiation, Ionizing; Reactive Oxygen Species; RNA, Small Interfering; Twist-Related Protein 1

2014
Differential in vivo genotoxicity of arsenic trioxide in glutathione depleted mouse bone marrow cells: expressions of Nrf2/Keap1/P62.
    Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Arsenic Trioxide; Arsenicals; Bone Marrow Cells; Buthionine Sulfoximine; Chromatids; Chromosome Aberrations; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Glutathione; Kelch-Like ECH-Associated Protein 1; Male; Membrane Glycoproteins; Mice; Mutagens; Neoplasm Proteins; NF-E2-Related Factor 2; Nuclear Pore Complex Proteins; Oxides

2015
The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells.
    The Journal of toxicological sciences, 2015, Volume: 40, Issue:3

    Topics: 1-Naphthylamine; Acetylcysteine; Antineoplastic Agents; Antioxidants; Arsenic Trioxide; Arsenicals; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Inactivation, Metabolic; Liver Neoplasms; Naphthalimides; NF-kappa B; Oxidative Stress; Oxides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones; Reactive Oxygen Species

2015
The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Acetylcysteine; Animals; Arsenic; Arsenic Trioxide; Arsenicals; Body Weight; Epididymis; Male; Mice; Organ Size; Oxides; Random Allocation; Reactive Oxygen Species; Sperm Motility; Spermatogenesis; Spermatozoa; Testis; Testosterone

2016
Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors.
    Biosensors & bioelectronics, 2016, Jun-15, Volume: 80

    Topics: Acetylcysteine; Arsenic Trioxide; Arsenicals; Biosensing Techniques; Dielectric Spectroscopy; Glutathione; Glutathione Disulfide; HL-60 Cells; Humans; Leukemia; Molecular Imprinting; Oxides; Polymers

2016
Decitabine shows synergistic effects with arsenic trioxide against myelodysplastic syndrome cells via endoplasmic reticulum stress-related apoptosis.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2019, Volume: 67, Issue:7

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Arsenic Trioxide; Cell Line, Tumor; Cell Proliferation; Decitabine; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Myelodysplastic Syndromes; Reactive Oxygen Species

2019
Characterization of the cellular effects and mechanism of arsenic trioxide-induced hepatotoxicity in broiler chickens.
    Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 61

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arsenic Trioxide; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chickens; Hepatocytes; Methionine Sulfoxide Reductases; Oxidative Stress; Reactive Oxygen Species

2019
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010