acetylcysteine and acrylonitrile

acetylcysteine has been researched along with acrylonitrile in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199010 (35.71)18.7374
1990's2 (7.14)18.2507
2000's3 (10.71)29.6817
2010's10 (35.71)24.3611
2020's3 (10.71)2.80

Authors

AuthorsStudies
Babiuk, C; Benz, FW; Nerland, DE; Pierce, WM1
Brodeur, J; Goyal, R; Tardif, R1
Linhart, I; Novák, J; Smejkal, J1
Brodeur, J; Gérin, M; Tardif, R1
Brodeur, J; Gérin, M; Talbot, D; Tardif, R1
Jakubowski, M; Kopecký, J; Linhart, I; Pielas, G1
Krivanek, ND; McLaughlin, M; Sprout, WL; Trochimowicz, HJ1
Frantík, E; Gut, I; Kopecký, J; Nerudová, J; Stiborová, A1
Bolt, HM; Buchter, A; Peter, H1
Gut, I; Kopecký, J; Zachardová, D1
Braun, WH; Langvardt, PW; Putzig, CL; Young, JD1
Hashimoto, K; Inomata, K; Ivanov, V; Kawai, T; Klimatskaya, L; Mizunuma, K1
Thier, R1
Fechter, L; Fulton, S; Gearhart, C; Nelson-Miller, A; Pouyatos, B1
Abdel-Naim, AB; El-Demerdash, E; El-Mesallamy, H; Esmat, A1
Satayavivad, J; Suntararuks, S; Thiantanawat, A; Visitnonthachai, D; Watcharasit, P1
Cheung, F; Errington, G; Minet, E; Scherer, G; Sterz, K1
Chiang, SY; Huang, YF; Shih, WC; Uang, SN; Wu, CF; Wu, KY1
Gao, N; Hou, H; Hu, Q; Tang, G; Xiong, W; Zhang, X1
Bertram, J; Kraus, T; Schettgen, T1
Lu, R; Ma, R; Sun, M; Sun, X; Xie, Y; Xu, W; Zhai, W; Zhu, W1
Klaunig, JE; Pu, X; Wang, Z; Zhou, S1
Aschner, M; Ben, L; Changsheng, Y; Fang, L; Guangwei, X; Hai, Q; Jing, M; Rongzhu, L; Shuhua, W; Wenjun, Z; Yu, B1
Lee, HL; Lin, CY; Su, TC; Sung, FC1
al'Absi, M; Allen, SS; Benowitz, NL; Carmella, SG; Chen, M; Cinciripini, PM; Denlinger-Apte, R; Donny, EC; Hatsukami, D; Hecht, SS; Jensen, J; Le, CT; Luo, X; McClernon, FJ; Murphy, SE; Robinson, JD; Sipe, C; Strasser, AA; Vandrey, R1
Carmella, SG; Chen, M; Hatsukami, DK; Hecht, SS; Jensen, JA; Le Marchand, L; Luo, X; Murphy, SE; Wilkens, LR1
Goldberg, E; Kindilien, S1
Chiang, SY; Huang, YF; Lee, YY; Luo, YS; Uang, SN; Wu, CF; Wu, KY1

Reviews

1 review(s) available for acetylcysteine and acrylonitrile

ArticleYear
Chemoprotection and interindividual differences in response to biological reactive intermediates.
    Advances in experimental medicine and biology, 2001, Volume: 500

    Topics: Acetylcysteine; Acrylonitrile; Animals; Antidotes; Carcinogens; Free Radical Scavengers; Genetic Predisposition to Disease; Globins; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Hydrocarbons, Brominated; Isoenzymes; Molecular Epidemiology; Occupational Diseases; Occupational Exposure; Poisoning; Thiosulfates

2001

Trials

1 trial(s) available for acetylcysteine and acrylonitrile

ArticleYear
Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020, 10-08, Volume: 22, Issue:10

    Topics: Acetylcysteine; Acrylonitrile; Aged; Biomarkers; Case-Control Studies; Female; Humans; Male; Middle Aged; Non-Smokers; Smokers; Smoking; Tobacco Use Disorder; United States

2020

Other Studies

26 other study(ies) available for acetylcysteine and acrylonitrile

ArticleYear
Acute acrylonitrile toxicity: studies on the mechanism of the antidotal effect of D- and L-cysteine and their N-acetyl derivatives in the rat.
    Toxicology and applied pharmacology, 1990, Volume: 102, Issue:1

    Topics: Acetylcysteine; Acrylonitrile; Acute Disease; Animals; Antidotes; Cysteine; Drug Evaluation, Preclinical; Isomerism; Lethal Dose 50; Male; Nitriles; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1990
Influence of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromoethane, and acrylonitrile: a dose-effect study.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:3

    Topics: Acetylcysteine; Acrylonitrile; Animals; Ethylene Dibromide; Ethylene Oxide; Glutathione; Hydrocarbons, Brominated; Kidney; Liver; Male; Nitriles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Time Factors

1989
N-acetyl-S-(1-cyano-2-hydroxyethyl)-L-cysteine, a new urinary metabolite of acrylonitrile and oxiranecarbonitrile.
    Archives of toxicology, 1988, Volume: 61, Issue:6

    Topics: Acetylcysteine; Acrylonitrile; Animals; Biotransformation; Ethylene Oxide; Female; Nitriles; Rats; Rats, Inbred Strains; Stereoisomerism; Thiazines

1988
Determination of specific urinary thioethers derived from acrylonitrile and ethylene oxide.
    IARC scientific publications, 1988, Issue:89

    Topics: Acetylcysteine; Acrylonitrile; Animals; Cysteine; Environmental Monitoring; Ethylene Oxide; Nitriles; Rats; Rats, Inbred Strains

1988
Urinary excretion of mercapturic acids and thiocyanate in rats exposed to acrylonitrile: influence of dose and route of administration.
    Toxicology letters, 1987, Volume: 39, Issue:2-3

    Topics: Acetylcysteine; Acrylonitrile; Administration, Inhalation; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intravenous; Male; Nitriles; Rats; Rats, Inbred Strains; Thiocyanates

1987
2-Cyanoethylmercapturic acid (CEMA) in the urine as a possible indicator of exposure to acrylonitrile.
    British journal of industrial medicine, 1987, Volume: 44, Issue:12

    Topics: Acetylcysteine; Acrylonitrile; Adult; Environmental Exposure; Half-Life; Humans; Lung; Male; Middle Aged; Nitriles; Urine

1987
Studies of possible acrylonitrile poisoning antidote.
    Texas medicine, 1985, Volume: 81, Issue:2

    Topics: Acetylcysteine; Acrylonitrile; Animals; Antidotes; Cysteine; Humans; Nitriles; Sodium Nitrite; Thiosulfates

1985
Acrylonitrile inhalation in rats: II. Excretion of thioethers and thiocyanate in urine.
    Journal of hygiene, epidemiology, microbiology, and immunology, 1985, Volume: 29, Issue:1

    Topics: Acetylcysteine; Acrylonitrile; Animals; Colorimetry; Environmental Exposure; Male; Nitriles; Rats; Rats, Inbred Strains; Thiocyanates; Time Factors

1985
[N-Acetylcysteine as an antidote in accidental acrylonitrile poisoning].
    International archives of occupational and environmental health, 1984, Volume: 53, Issue:4

    Topics: Acetylcysteine; Acrylonitrile; Aerosols; Animals; Antidotes; Nitriles; Rats; Rats, Inbred Strains

1984
New findings on acrylonitrile metabolism.
    Czechoslovak medicine, 1980, Volume: 3, Issue:4

    Topics: Acetylcysteine; Acrylonitrile; Administration, Oral; Animals; Chromatography, Gel; Chromatography, Paper; Cysteine; Injections, Intraperitoneal; Injections, Intravenous; Nitriles; Rabbits; Rats

1980
Identification of the major urinary metabolites of acrylonitrile in the rat.
    Journal of toxicology and environmental health, 1980, Volume: 6, Issue:2

    Topics: Acetylcysteine; Acrylonitrile; Animals; Biotransformation; Cysteine; Male; Nitriles; Rats; Thiazines; Thiocyanates

1980
Biological monitoring of acrylonitrile exposure through a new analytical approach to hemoglobin and plasma protein adducts and urinary metabolites in rats and humans.
    International archives of occupational and environmental health, 1993, Volume: 65, Issue:1 Suppl

    Topics: Acetylcysteine; Acrylonitrile; Animals; Blood Proteins; Chromatography, Gas; Environmental Exposure; Environmental Monitoring; Hemoglobins; Humans; Male; Rats; Rats, Wistar

1993
Oxidative stress pathways in the potentiation of noise-induced hearing loss by acrylonitrile.
    Hearing research, 2007, Volume: 224, Issue:1-2

    Topics: Acetylcysteine; Acrylonitrile; Action Potentials; Animals; Antioxidants; Cochlea; Cyanides; Fomepizole; Glutathione; Hearing Loss, Noise-Induced; Liver; Male; Otoacoustic Emissions, Spontaneous; Oxidative Stress; Pyrazoles; Rats; Rats, Long-Evans; Reactive Oxygen Species; Thiosulfates

2007
Toxicity and oxidative stress of acrylonitrile in rat primary glial cells: preventive effects of N-acetylcysteine.
    Toxicology letters, 2007, Jul-10, Volume: 171, Issue:3

    Topics: Acetylcysteine; Acrylonitrile; Adenosine Triphosphate; Animals; Cell Survival; Cyanides; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Glutathione; Immunohistochemistry; L-Lactate Dehydrogenase; Lipid Peroxidation; Neuroglia; Oxidative Stress; Rats

2007
Acrylonitrile induced apoptosis via oxidative stress in neuroblastoma SH-SY5Y cell.
    Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:7

    Topics: Acetylcysteine; Acrylonitrile; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Death; Cell Line, Tumor; Cell Survival; Enzyme Activation; Humans; Neuroblastoma; Oxidative Stress; Poly(ADP-ribose) Polymerases

2010
Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011, Volume: 16, Issue:1

    Topics: Acetylcysteine; Acrylonitrile; Biomarkers; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Molecular Structure; Nicotine; Nitrosamines; Pyridines; Smoking; Tandem Mass Spectrometry; Tars

2011
Simultaneous quantitation of urinary cotinine and acrylonitrile-derived mercapturic acids with ultraperformance liquid chromatography-tandem mass spectrometry.
    Analytical and bioanalytical chemistry, 2012, Volume: 402, Issue:6

    Topics: Acetylcysteine; Acrylonitrile; Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Humans; Sensitivity and Specificity; Smoking; Tandem Mass Spectrometry

2012
A column-switching liquid chromatography-tandem mass spectrometry method for quantitation of 2-cyanoethylmercapturic acid and 2-hydroxyethylmercapturic acid in Chinese smokers.
    Analytical biochemistry, 2012, Nov-01, Volume: 430, Issue:1

    Topics: Acetylcysteine; Acrylonitrile; Adult; Asian People; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Middle Aged; Reproducibility of Results; Smoking; Tandem Mass Spectrometry; Time Factors; Urinalysis; Young Adult

2012
Accurate quantification of the mercapturic acids of acrylonitrile and its genotoxic metabolite cyanoethylene-epoxide in human urine by isotope-dilution LC-ESI/MS/MS.
    Talanta, 2012, Aug-30, Volume: 98

    Topics: Acetylcysteine; Acrylonitrile; Adult; Aged; Chromatography, Liquid; Ethylene Oxide; Female; Humans; Indicator Dilution Techniques; Limit of Detection; Male; Middle Aged; Occupational Exposure; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2012
Cytotoxic effects of acrylonitrile on human umbilical cord mesenchymal stem cells in vitro.
    Molecular medicine reports, 2014, Volume: 9, Issue:1

    Topics: Acetylcysteine; Acrylonitrile; Antioxidants; Apoptosis; Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Osteogenesis; Umbilical Cord

2014
Protective effects of antioxidants on acrylonitrile-induced oxidative stress in female F344 rats.
    Environmental toxicology, 2016, Volume: 31, Issue:12

    Topics: Acetylcysteine; Acrylonitrile; Animals; Antioxidants; Biomarkers; Brain; Camellia sinensis; Carcinogens; Dietary Supplements; DNA Damage; Female; Oxidative Stress; Polyphenols; Rats, Inbred F344; Selenium; Taurine; Vitamin E

2016
Differential protection of pre- versus post-treatment with curcumin, Trolox, and N-acetylcysteine against acrylonitrile-induced cytotoxicity in primary rat astrocytes.
    Neurotoxicology, 2015, Volume: 51

    Topics: Acetylcysteine; Acrylonitrile; Animals; Antioxidants; Astrocytes; Cell Survival; Cells, Cultured; Chromans; Curcumin; Cytotoxins; Glutathione; Lipid Peroxidation; Membrane Potential, Mitochondrial; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Rats; Reactive Oxygen Species

2015
Investigating the association between urinary levels of acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine and the oxidative stress product 8-hydroxydeoxyguanosine in adolescents and young adults.
    Environmental pollution (Barking, Essex : 1987), 2018, Volume: 239

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Acrylonitrile; Adolescent; Adult; Asian People; Biomarkers; Deoxyguanosine; Environmental Exposure; Female; Humans; Male; Oxidative Stress; Smoking; Young Adult

2018
Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Acetylcysteine; Acrolein; Acrylonitrile; Adult; Biomarkers; Cigarette Smoking; Female; Hazardous Substances; Humans; Longitudinal Studies; Male; Middle Aged; Randomized Controlled Trials as Topic; Smokers; Tobacco Products; Toxicology

2019
Household tobacco smoke exposure and acrylonitrile metabolite levels in a US pediatric sample.
    Environmental toxicology and pharmacology, 2021, Volume: 84

    Topics: Acetylcysteine; Acrylonitrile; Adolescent; Air Pollutants; Biological Monitoring; Child; Child, Preschool; Female; Housing; Humans; Inhalation Exposure; Male; Nutrition Surveys; Tobacco Smoke Pollution

2021
Study of urinary mercapturic acids as biomarkers of human acrylonitrile exposure.
    Toxicology letters, 2023, Jan-15, Volume: 373

    Topics: Acetylcysteine; Acrylonitrile; Animals; Biomarkers; Cotinine; Humans; Mice; Rats

2023