Compounds > acetylcysteine

acetylcysteine and acrolein

acetylcysteine has been researched along with acrolein in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-199011 (14.29)18.7374
1990's5 (6.49)18.2507
2000's18 (23.38)29.6817
2010's34 (44.16)24.3611
2020's9 (11.69)2.80

Authors

AuthorsStudies
Cox, PJ1
Giles, PM1
Alarcon, RA1
Ansari, GA; Boor, PJ; Nelson, TJ; Sanduja, R1
Sprince, H1
Chaviano, AH; Gill, WB; Ruggiero, KJ; Vermeulen, CW1
Kaye, CM1
Anundi, I; Dawson, JR; Moldéus, P; Norbeck, K1
Bansal, SK; Berrigan, MJ; Gurtoo, HL; Marinello, AJ; Paul, B; Pavelic, ZP; Struck, RF1
Saiers, JH; Slavik, M1
Delbressine, LP; Klippert, PJ; Reuvers, JT; Seuttler-Berlage, F1
Ahmed, T; Fraiser, LH; Kehrer, JP; Mamiya, B; Ramu, K1
Frantík, E; Linhart, I; Mitera, J; Smejkal, J; Vodicková, L; Vosmanská, M1
Abeles, AJ; Block, ER; Patel, JM1
Ahmed, T; Kehrer, JP; Pakenham, G; Perry, CS; Ramu, K1
Bartsch, H; Hergenhahn, M; Weninger, A; Yang, Q1
Butterfield, DA; Cardin, AL; Lauderback, CM; Pocernich, CB; Racine, CL1
Han, DC; Jeon, SB; Kim, HC; Kim, HM; Kim, JM; Kwon, BM; Lee, MY; Shin, KD; Son, KH1
Lin, CC; Ng, LT; Wu, SJ1
Fujiwara, N; Koh, YH; Misonou, Y; Miyamoto, Y; Park, YS; Suzuki, K; Takahashi, M; Taniguchi, N1
Barhoumi, R; Johnson, CD; Lu, KP; Meininger, GA; Partridge, CR; Ramos, KS; Tadesse, MG; Williams, ES; Wilson, E1
Freed, BM; Lambert, C; Lazis, A; Li, J; McCue, J; Ouyang, Y; Portas, M; Rosano, TG1
Averill-Bates, DA; Tanel, A1
Carmella, SG; Chen, M; Hatsukami, DK; Hecht, SS; Zhang, S; Zhang, Y1
Gugliucci, A; Kimura, S; Kinugasa, E; Lunceford, N; Ogata, H; Schulze, J1
Bhatnagar, A; Cai, J; Gu, Y; Hill, BG; Luo, J; Prabhu, SD; Srivastava, S1
Myers, CR; Szadkowski, A1
Kraus, T; Musiol, A; Schettgen, T1
Auerbach, SS; Irwin, RD; Mahler, J; Travlos, GS1
Gavin, T; Geohagen, BC; Lopachin, RM1
Goda, H; Hagihara, M; Higashi, K; Igarashi, K; Kashiwagi, K; Machi, Y; Niitsu, M; Ohya, T; Tomitori, H; Yoshida, M1
Bhatnagar, A; Conklin, DJ; Haberzettl, P; Prough, RA1
Igarashi, K; Ishii, I; Kashiwagi, K; Nishimura, K; Okuyama, S; Omura, T; Saiki, R1
Bhatnagar, A; Conklin, DJ; Haberzettl, P; Lesgards, JF; Prough, RA; Srivastava, S1
Borgerding, MF; Brown, BG; Byrd, GD; Yan, W1
Civelli, M; Facchinetti, F; Moretto, N; Patacchini, R; Volpi, G1
Carmella, SG; Chen, JG; Chen, M; Chen, TY; Egner, PA; Fahey, JW; Groopman, JD; Hecht, SS; Jacobson, LP; Kensler, TW; Muñoz, A; Ng, D; Qian, GS; Talalay, P; Yuan, JM1
Fukuda, K; Higashi, K; Igarashi, K; Ishii, I; Kashiwagi, K; Mikami, T; Mizoi, M; Nakamura, T; Nishimura, K; Saiki, R; Toida, T; Tomitori, H; Yoshida, M1
Borok, Z; Davies, KJ; Forman, HJ; Liu, H; Ursini, F; Zhang, H1
Abuladze, N; Bragin, A; Cascio, D; Damoiseaux, R; Faull, K; Pushkin, A; Schibler, MJ; Tsirulnikov, K1
Baum, M; Berger, F; Doroshyenko, O; Eisenbrand, G; Feld, J; Fuhr, U; Richling, E; Scherbl, D; Tomalik-Scharte, D; Watzek, N1
Cooper, B; Jannasch, A; Park, J; Shi, R; Tully, M; Walls, M; Zheng, L1
Baba, SP; Barski, OA; Bhatnagar, A; Cai, J; Conklin, DJ; Hoetker, JD; Klein, JB; Merchant, M1
Carmella, SG; Chen, M; Hecht, SS; Zarth, A1
Abplanalp, W; Becher, C; Bhatnagar, A; Chugh, A; Ciszewski, T; Conklin, DJ; DeFilippis, A; DeJarnett, N; Hamzeh, I; Higdon, D; McCracken, J; Myers, JA; O'Toole, TE; Prabhu, SD; Rai, SN; Ramos, KS; Riggs, DW; Srivastava, S; Tollerud, DJ; Wagner, S; Wyatt, B; Xie, Z; Yeager, R1
Aizenbud, D; Avezov, K; Reznick, AZ1
Acosta, G; Shi, R; Tian, R; Tully, M; Zheng, L1
Higashi, K; Igarashi, K; Kashiwagi, K; Kuni, K; Mizoi, M; Nakamura, M; Saiki, R; Toida, T; Uemura, K; Waragai, M; Yoshida, M1
Arai, T; Kitamura, D; Koyama, R; Mizuta, R; Yuasa, M1
Carmella, SG; Chen, M; Hecht, SS; Koh, WP; Murphy, SE; Wang, R; Yuan, JM1
Chen, N; Isobe, K; Ito, S; Liu, L; Nishio, N; Sun, Y; Tanaka, Y1
Alwis, KU; Blount, BC; deCastro, BR; Morrow, JC1
Carmella, SG; Chen, M; Haiman, CA; Hecht, SS; Le Marchand, L; Park, SL; Patel, Y; Stram, DO1
Goniewicz, ML; Hajek, P; Knight-West, O; McRobbie, H; Phillips, A; Przulj, D; Smith, KM1
Acosta, G; Cao, P; Chen, Z; Muratori, B; Park, J; Shi, R; Vega-Alvarez, S; Zheng, L1
Attanasio, R; Feroe, AG; Scinicariello, F1
Higashi, K; Igarashi, K; Toida, T1
Benedikter, BJ; Haenen, GRMM; Reynaert, NL; Rohde, GGU; Savelkoul, PHM; Stassen, FRM; van Eijck, PH; Volgers, C; Weseler, AR; Wouters, EFM1
Carmella, SG; Chatfield, DA; Daffa, RM; Hecht, SS; Hovell, MF; Jackson, SR; Kassem, NO; Kassem, NOF; Liles, S; Zarth, AT1
Basak, R; Borgas, D; Chambers, E; Choudhary, G; Lange, T; Lu, Q; Mundy, M; Newton, J; Oldham, M; Rounds, S; Yao, H1
Kawano, Y; Kurauchi, K; Miyahara, E; Nishikawa, T; Okamoto, Y1
Chen, SP; Fuh, JL; Hsu, WC; Liu, TY; Tsou, HH; Wang, HT1
Ku, HJ; Lee, JH; Park, JH; Park, JW1
Higashi, K; Igarashi, K; Kashiwagi, K; Kitajima, M; Ko, K; Kogure, N; Sakamoto, A; Sugita, Y; Takao, K; Takayama, H; Terui, Y; Toida, T; Uemura, T; Watanabe, K1
Cox, S; Dawkins, L; Doig, M; Goniewicz, M; Kimber, C; Kośmider, L; McRobbie, H1
al'Absi, M; Allen, SS; Benowitz, NL; Carmella, SG; Chen, M; Cinciripini, PM; Denlinger-Apte, R; Donny, EC; Hatsukami, D; Hecht, SS; Jensen, J; Le, CT; Luo, X; McClernon, FJ; Murphy, SE; Robinson, JD; Sipe, C; Strasser, AA; Vandrey, R1
De Jesús, VR; Holder, C; Johnson, JM; Muilenburg, JL; Naeher, LP; Rathbun, SL; Sosnoff, C; Wang, JS; Wang, L; Xia, B; Yu, X1
Abraham, K; Bakuradze, T; Eisenbrand, G; Goerke, K; Lampen, A; Richling, E; Ruenz, M1
Carmella, SG; Chen, M; Hecht, SS; Li, Y; Zhao, Y1
Harahap, Y; Melhan, M; Muhammad, C; Purwanto, DJ; Yanuar, A1
Baek, SH; Park, J1
Pourahmad, J; Rezaei, M; Shafie, B1
Acosta, G; Andrews, KD; Cao, J; Dietrich, AD; Liu, Z; Lu, KH; Lungwitz, EA; Majumdar, S; Race, NS; Shekhar, A; Shi, R; Truitt, WA; Vega Alvarez, SM; Warner, TR1
Bhatnagar, A; Conklin, DJ; Jin, L; Lorkiewicz, P; Srivastava, S; Xie, Z1
Chang, YP; Cheng, HW; Kuo, CW; Lin, CC; Liu, WS; Lu, SH; Tong, ZJ; Tsai, MT; Tsou, HH; Wang, HT; Yen, PC1
Pluym, N; Scherer, G; Scherer, M1
Bhatnagar, A; Chen, JY; Gao, H; Keith, RJ; Lorkiewicz, P; Srivastava, S; Xie, Z1

Reviews

1 review(s) available for acetylcysteine and acrolein

ArticleYear
Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:6

    Topics: Acetylcysteine; Acrolein; Animals; Biomarkers; Humans; Severity of Illness Index; Stroke

2016

Trials

1 trial(s) available for acetylcysteine and acrolein

ArticleYear
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.
    Carcinogenesis, 2012, Volume: 33, Issue:1

    Topics: Acetylcysteine; Acrolein; Adult; Air Pollutants; Aldehydes; Benzene; Beverages; Biomarkers; Brassica; China; DNA Adducts; Ethylene Oxide; Female; Glucosinolates; Humans; Imidoesters; Isothiocyanates; Male; Middle Aged; Oximes; Polycyclic Aromatic Hydrocarbons; Smoking; Sulfoxides; Thiocyanates

2012

Other Studies

75 other study(ies) available for acetylcysteine and acrolein

ArticleYear
Cyclophosphamide cystitis--identification of acrolein as the causative agent.
    Biochemical pharmacology, 1979, Jul-01, Volume: 28, Issue:13

    Topics: Acetylcysteine; Acrolein; Aldehydes; Animals; Carcinoma 256, Walker; Cyclophosphamide; Cystitis; Female; Male; Organ Size; Rats; Urinary Bladder

1979
The biosynthesis of 3-hydroxypropylmercapturic acid from cyclophosphamide.
    Xenobiotica; the fate of foreign compounds in biological systems, 1979, Volume: 9, Issue:12

    Topics: Acetylcysteine; Acrolein; Animals; Bile; Chromatography, Paper; Cyclophosphamide; Cysteine; Glutathione; Liver; Rats

1979
Studies on the in vivo formation of acrolein: 3-hydroxy-propylmercapturic acid as an index of cyclophosphamide (NSC-26271) activation.
    Cancer treatment reports, 1976, Volume: 60, Issue:4

    Topics: Acetylcysteine; Acrolein; Aldehydes; Alkylation; Animals; Chemical Phenomena; Chemistry; Cyclophosphamide; Glutathione; Humans; In Vitro Techniques; Male; Microsomes, Liver; Rats; Sulfhydryl Compounds

1976
In vivo metabolism of the cardiovascular toxin, allylamine.
    Biochemical pharmacology, 1987, Dec-15, Volume: 36, Issue:24

    Topics: Acetylcysteine; Acrolein; Allylamine; Amines; Animals; Biotransformation; Chromatography, High Pressure Liquid; Glutathione; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Rats

1987
Protective action of sulfur compounds against aldehyde toxicants of cigarette smoke.
    European journal of respiratory diseases. Supplement, 1985, Volume: 139

    Topics: Acetaldehyde; Acetylcysteine; Acrolein; Aldehydes; Animals; Cysteine; Formaldehyde; Lethal Dose 50; Male; Nicotiana; Plants, Toxic; Rats; Respiratory System; Smoke; Sulfur

1985
Experimental cytoxan cystitis and prevention by acetylcysteine.
    The Journal of urology, 1985, Volume: 134, Issue:3

    Topics: Acetylcysteine; Acrolein; Animals; Cyclophosphamide; Cystitis; Female; Rats; Urinary Bladder

1985
Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein.
    The Biochemical journal, 1973, Volume: 134, Issue:4

    Topics: Acetylcysteine; Acrolein; Alcohols; Aldehydes; Allyl Compounds; Animals; Bile; Chromatography, Paper; Esters; Formates; Injections, Subcutaneous; Male; Nitrates; Phosphates; Propionates; Rats; Sulfoxides; Sulfur Isotopes

1973
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat.
    Archives of toxicology, 1984, Volume: 55, Issue:1

    Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Maleates; Paraquat; Phenobarbital; Rats; Rats, Inbred Strains

1984
Effect of thiols on toxicity and carcinostatic activity of cyclophosphamide.
    Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1

    Topics: Acetylcysteine; Acrolein; Animals; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Interactions; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phosphoramide Mustards; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Urinary Bladder

1983
Phase I clinical study of acetylcysteine's preventing ifosfamide-induced hematuria.
    Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1

    Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Hematuria; Humans; Ifosfamide; Lung Neoplasms

1983
Isolation and identification of mercapturic acids of cinnamic aldehyde and cinnamyl alcohol from urine of female rats.
    Archives of toxicology, 1981, Volume: 49, Issue:1

    Topics: 1-Propanol; Acetylcysteine; Acrolein; Aldehydes; Animals; Female; Mass Spectrometry; Propanols; Rats

1981
Acrolein mercapturates: synthesis, characterization, and assessment of their role in the bladder toxicity of cyclophosphamide.
    Chemical research in toxicology, 1995, Volume: 8, Issue:4

    Topics: Acetylcysteine; Acrolein; Animals; Chromatography, Thin Layer; Cyclophosphamide; Hemoglobins; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Phenylhydrazines; Semicarbazones; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Urinary Bladder Diseases

1995
Biotransformation of acrolein in rat: excretion of mercapturic acids after inhalation and intraperitoneal injection.
    Toxicology and applied pharmacology, 1996, Volume: 136, Issue:1

    Topics: Acetylcysteine; Acrolein; Administration, Inhalation; Animals; Biotransformation; Blood-Air Barrier; Dose-Response Relationship, Drug; Ethers; Injections, Intraperitoneal; Male; Mice; Rats; Rats, Wistar

1996
Nitric oxide exposure and sulfhydryl modulation alter L-arginine transport in cultured pulmonary artery endothelial cells.
    Free radical biology & medicine, 1996, Volume: 20, Issue:5

    Topics: Acetylcysteine; Acrolein; Animals; Arginine; Biological Transport; Cells, Cultured; Dithiothreitol; Endothelium, Vascular; Ethylmaleimide; L-Lactate Dehydrogenase; Lipid Peroxidation; Nitrates; Nitric Oxide; Nitrites; Penicillamine; Pulmonary Artery; S-Nitroso-N-Acetylpenicillamine; Sulfhydryl Compounds; Swine

1996
Studies on the basis for the toxicity of acrolein mercapturates.
    Toxicology and applied pharmacology, 1996, Volume: 140, Issue:2

    Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Cyclophosphamide; Growth Inhibitors; Humans; Lung Neoplasms; Tumor Cells, Cultured

1996
Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Acetaldehyde; Acetylcysteine; Acrolein; Aldehydes; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; B-Lymphocytes; beta-Naphthoflavone; Biotransformation; Burkitt Lymphoma; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; DNA, Neoplasm; Formaldehyde; Free Radical Scavengers; Gamma Rays; Humans; Mixed Function Oxygenases; N-Glycosyl Hydrolases; Oxidation-Reduction; Reactive Oxygen Species; Smoke

1999
Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease.
    Neurochemistry international, 2001, Volume: 39, Issue:2

    Topics: Acetylcysteine; Acrolein; Animals; Brain; Cell Membrane; Electron Spin Resonance Spectroscopy; Female; Gerbillinae; Glutathione; Lipid Peroxidation; Nerve Tissue Proteins; Neurodegenerative Diseases; Synaptosomes

2001
2'-benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Acetylcysteine; Acrolein; Aldehydes; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Benzoates; Blotting, Western; Carcinoma; Caspase 3; Caspases; Cell Cycle; Cell Line, Tumor; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; ErbB Receptors; Farnesyltranstransferase; Flow Cytometry; Genes, p53; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Precipitin Tests; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Time Factors

2004
Effects of vitamin E on the cinnamaldehyde-induced apoptotic mechanism in human PLC/PRF/5 cells.
    Clinical and experimental pharmacology & physiology, 2004, Volume: 31, Issue:11

    Topics: Acetylcysteine; Acrolein; Annexin A5; Antioxidants; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Line; Cell Proliferation; Complement Membrane Attack Complex; Complement System Proteins; Cytochromes c; Cytosol; Enzyme Activation; Genes, bcl-2; Glycoproteins; High-Temperature Requirement A Serine Peptidase 2; Humans; Indicators and Reagents; Mitochondria; Mitochondrial Proteins; Reactive Oxygen Species; Serine Endopeptidases; Signal Transduction; Vitamin E

2004
Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells.
    Biochemical and biophysical research communications, 2005, Feb-25, Volume: 327, Issue:4

    Topics: Acetylcysteine; Acrolein; Antioxidants; Cells, Cultured; Cycloheximide; Dactinomycin; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Humans; Oxidative Stress; RNA, Messenger; Thioredoxin-Disulfide Reductase; Umbilical Veins

2005
Novel genomic targets in oxidant-induced vascular injury.
    Journal of molecular and cellular cardiology, 2005, Volume: 38, Issue:6

    Topics: Acetylcysteine; Acrolein; Allylamine; Animals; Aorta; Blotting, Western; Cluster Analysis; Cytoskeleton; Dinoprost; Dose-Response Relationship, Drug; Gene Expression Regulation; Genome; Glutathione; Humans; Hydrogen Peroxide; Image Processing, Computer-Assisted; In Situ Hybridization, Fluorescence; Integrin alpha1; Integrins; Male; Microscopy, Fluorescence; NF-kappa B; Oligonucleotide Array Sequence Analysis; Osteopontin; Oxidants; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sialoglycoproteins; Tropomyosin

2005
Acrolein in cigarette smoke inhibits T-cell responses.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:4

    Topics: Acetylcysteine; Acrolein; Adult; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Gene Expression; Humans; Immunosuppressive Agents; In Vitro Techniques; Interferon-gamma; Interleukin-2; Nicotiana; RNA, Messenger; Smoke; T-Lymphocytes; Tumor Necrosis Factor-alpha

2005
Inhibition of acrolein-induced apoptosis by the antioxidant N-acetylcysteine.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:1

    Topics: Acetylcysteine; Acrolein; Animals; Antioxidants; Apoptosis; Caspases; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Glutathione; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Signal Transduction; Subcellular Fractions

2007
Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking.
    Chemical research in toxicology, 2007, Volume: 20, Issue:7

    Topics: Acetylcysteine; Acrolein; Atmospheric Pressure; Biomarkers; Chromatography, Liquid; Humans; Molecular Structure; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2007
Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients.
    Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 384, Issue:1-2

    Topics: Acetylcysteine; Acrolein; Aged; Aryldialkylphosphatase; Cysteine; Female; Humans; Kidney Failure, Chronic; Lipoproteins, HDL; Male; Middle Aged; Renal Dialysis; Treatment Outcome

2007
Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6

    Topics: Acetylcysteine; Acrolein; Aldehydes; Animals; Antioxidants; Calcium Signaling; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Environmental Exposure; Environmental Pollutants; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; Protein Carbonylation; Proteomics; Risk Assessment; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfhydryl Compounds; Ventricular Dysfunction, Left; Ventricular Pressure

2007
Acrolein oxidizes the cytosolic and mitochondrial thioredoxins in human endothelial cells.
    Toxicology, 2008, Jan-14, Volume: 243, Issue:1-2

    Topics: Acetylcysteine; Acrolein; Cell Line; Cytosol; Endothelial Cells; Endothelium, Vascular; Environmental Pollutants; Humans; Mitochondria; Oxidation-Reduction; Thioredoxins

2008
Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acrolein (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography/tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2008, Volume: 22, Issue:17

    Topics: Acetylcysteine; Acrolein; Acrylamide; Adult; Biomarkers; Chromatography, High Pressure Liquid; Dimethylformamide; Environmental Monitoring; Epoxy Compounds; Ethylene Oxide; Female; Humans; Male; Middle Aged; Occupational Exposure; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2008
A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein.
    Toxicology, 2008, Nov-20, Volume: 253, Issue:1-3

    Topics: Acetates; Acetylcysteine; Acrolein; Allyl Compounds; Animals; Blood Cell Count; Female; Gastric Mucosa; Hematopoietic System; Liver; Lymphoid Tissue; Male; Mice; Propanols; Rats; Rats, Inbred F344; Stomach; Survival Rate; Toxicity Tests

2008
Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:1

    Topics: Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Biological Transport; Carnosine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Male; Mechanics; Nonlinear Dynamics; Oxidative Stress; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Regression Analysis; Sulfhydryl Compounds; Synaptosomes; Transport Vesicles; Tritium

2009
Acrolein toxicity: Comparison with reactive oxygen species.
    Biochemical and biophysical research communications, 2009, Jan-09, Volume: 378, Issue:2

    Topics: Acetylcysteine; Acrolein; Animals; Cell Line, Tumor; Cell Proliferation; Hydrogen Peroxide; Hydroxylamines; Macromolecular Substances; Mice; Oxidative Stress; Protein Biosynthesis; Putrescine; Reactive Oxygen Species; Singlet Oxygen; Spermidine

2009
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5

    Topics: Acetylcholine; Acetylcysteine; Acrolein; Animals; Antioxidants; Aorta, Thoracic; Blood Proteins; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione S-Transferase pi; Inhalation Exposure; Lung; Male; Mice; Mice, Knockout; Nicotiana; Nitroprusside; Oxidative Stress; Smoke; Vasodilation; Vasodilator Agents

2009
Intense correlation between brain infarction and protein-conjugated acrolein.
    Stroke, 2009, Volume: 40, Issue:10

    Topics: Acetylcysteine; Acrolein; Animals; Brain; Carrier Proteins; Disease Models, Animal; Down-Regulation; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Photochemistry; Rose Bengal; Spermidine; Spermine; Time Factors; Up-Regulation

2009
Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2

    Topics: Acetylcysteine; Acrolein; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cystitis; Glutathione Transferase; Hemorrhage; Immunohistochemistry; In Situ Nick-End Labeling; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Reverse Transcriptase Polymerase Chain Reaction; Urinary Bladder; Urinary Bladder Diseases

2009
Development and validation of a direct LC-MS-MS method to determine the acrolein metabolite 3-HPMA in urine.
    Journal of chromatographic science, 2010, Volume: 48, Issue:3

    Topics: Acetylcysteine; Acrolein; Chromatography, Liquid; Humans; Limit of Detection; Tandem Mass Spectrometry

2010
Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts.
    British journal of pharmacology, 2011, Volume: 163, Issue:3

    Topics: Acetylcysteine; Acrolein; Aldehydes; Bronchi; Calcium Channels; Cells, Cultured; Complex Mixtures; Fibroblasts; Humans; Lung; Myocytes, Smooth Muscle; Nerve Tissue Proteins; Nicotiana; Nicotinic Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger; Smoke; Transient Receptor Potential Channels; TRPA1 Cation Channel; Vascular Endothelial Growth Factor A

2011
Inverse correlation between stroke and urinary 3-hydroxypropyl mercapturic acid, an acrolein-glutathione metabolite.
    Clinica chimica acta; international journal of clinical chemistry, 2012, Apr-11, Volume: 413, Issue:7-8

    Topics: Acetylcysteine; Acrolein; Adult; Aged; Case-Control Studies; Chromatography, Liquid; Female; Glutathione; Humans; Male; Middle Aged; Stroke; Tandem Mass Spectrometry

2012
Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation.
    Free radical biology & medicine, 2012, Apr-15, Volume: 52, Issue:8

    Topics: Acetylcysteine; Acrolein; Catalase; Cell Line, Tumor; Enzyme Activation; Epithelial-Mesenchymal Transition; Humans; Nicotiana; Smoke; src-Family Kinases

2012
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.
    Toxicology and applied pharmacology, 2012, Sep-15, Volume: 263, Issue:3

    Topics: Acetylation; Acetylcysteine; Acrolein; Aldehydes; Alzheimer Disease; Amidohydrolases; Aminooxyacetic Acid; Animals; Cerebral Cortex; Enzyme Inhibitors; Male; Neurons; Parkinson Disease; Rats; Rats, Wistar

2012
Profiling of mercapturic acids of acrolein and acrylamide in human urine after consumption of potato crisps.
    Molecular nutrition & food research, 2012, Volume: 56, Issue:12

    Topics: Acetylcysteine; Acrolein; Acrylamide; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cooking; Creatinine; Food Contamination; Gas Chromatography-Mass Spectrometry; Hot Temperature; Humans; Isotopes; Male; Solanum tuberosum; Tandem Mass Spectrometry

2012
Determination of urine 3-HPMA, a stable acrolein metabolite in a rat model of spinal cord injury.
    Journal of neurotrauma, 2013, Aug-01, Volume: 30, Issue:15

    Topics: Acetylcysteine; Acrolein; Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Immunoblotting; Male; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tandem Mass Spectrometry

2013
Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates.
    The Journal of biological chemistry, 2013, Sep-27, Volume: 288, Issue:39

    Topics: Acetylcysteine; Acrolein; Aldehyde Reductase; Animals; Antioxidants; Carnosine; Humans; Inflammation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Reperfusion Injury; Tissue Distribution

2013
High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers' urine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Sep-15, Volume: 935

    Topics: Acetylcysteine; Acrolein; Aldehydes; Chromatography, Liquid; High-Throughput Screening Assays; Humans; Limit of Detection; Reproducibility of Results; Smoking; Solid Phase Extraction; Tandem Mass Spectrometry

2013
Acrolein exposure is associated with increased cardiovascular disease risk.
    Journal of the American Heart Association, 2014, Aug-06, Volume: 3, Issue:4

    Topics: Acetylcysteine; Acrolein; Adult; Aged; Blood Platelets; C-Reactive Protein; Cardiovascular Diseases; Environmental Exposure; Female; Humans; Kentucky; Leukocytes; Linear Models; Male; Middle Aged; Platelet Activation; Smoking

2014
Time and dose effects of cigarette smoke and acrolein on protein carbonyl formation in HaCaT keratinocytes.
    Advances in experimental medicine and biology, 2015, Volume: 849

    Topics: Acetylcysteine; Acrolein; Aldehydes; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Keratinocytes; Protein Carbonylation; Smoking; Tobacco Products; Tobacco Smoke Pollution

2015
Acute systemic accumulation of acrolein in mice by inhalation at a concentration similar to that in cigarette smoke.
    Neuroscience bulletin, 2014, Volume: 30, Issue:6

    Topics: Acetylcysteine; Acrolein; Administration, Inhalation; Animals; Creatinine; Mice; Spinal Cord

2014
Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Feb-20, Volume: 441

    Topics: Acetylcysteine; Acrolein; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged

2015
Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose.
    Biomedical research (Tokyo, Japan), 2014, Volume: 35, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Acrolein; Animals; Blotting, Western; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Mesna; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction

2014
Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Asian People; Benzene; Biomarkers; Carcinogens; Cooking; Female; Humans; Lung Neoplasms; Middle Aged; Singapore; Smoking

2015
Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Acetylcysteine; Acrolein; Animals; Apoptosis; Cells, Cultured; Endoplasmic Reticulum Stress; Epithelial Cells; Female; Inflammation; Lung; Lung Injury; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering

2015
Acrolein Exposure in U.S. Tobacco Smokers and Non-Tobacco Users: NHANES 2005-2006.
    Environmental health perspectives, 2015, Volume: 123, Issue:12

    Topics: Acetylcysteine; Acrolein; Adolescent; Adult; Biomarkers; Child; Cotinine; Environmental Pollutants; Female; Humans; Male; Middle Aged; Nutrition Surveys; Smoking; United States

2015
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Ethnicity; Female; Hawaii; Humans; Lung Neoplasms; Male; Middle Aged; Risk Factors; Smoking

2015
Effects of Switching to Electronic Cigarettes with and without Concurrent Smoking on Exposure to Nicotine, Carbon Monoxide, and Acrolein.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:9

    Topics: Acetylcysteine; Acrolein; Adult; Aerosols; Biomarkers; Breath Tests; Carbon Monoxide; Cohort Studies; Cotinine; Electronic Nicotine Delivery Systems; Female; Humans; Male; Middle Aged; Nicotine; Smoke; Smoking; Smoking Cessation

2015
Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.
    Journal of neurochemistry, 2015, Volume: 135, Issue:5

    Topics: Acetylcysteine; Acrolein; Animals; Disease Models, Animal; Ganglia, Spinal; Hydralazine; Hyperalgesia; Locomotion; Male; Neuralgia; Pain Threshold; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord; Spinal Cord Injuries; TRPA1 Cation Channel; TRPC Cation Channels; Up-Regulation; Vasodilator Agents

2015
Acrolein metabolites, diabetes and insulin resistance.
    Environmental research, 2016, Volume: 148

    Topics: Acetylcysteine; Acrolein; Adult; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Insulin Resistance; Male; Nutrition Surveys

2016
Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants.
    Free radical biology & medicine, 2017, Volume: 108

    Topics: Acetylcysteine; Acrolein; Antioxidants; Cell Line; Cigarette Smoking; Exosomes; Extracellular Vesicles; Flow Cytometry; Humans; Oxidation-Reduction; Oxidative Stress; Respiratory Mucosa; Sulfhydryl Compounds; Tetraspanin 28; Tetraspanin 30

2017
Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2018, 03-06, Volume: 20, Issue:4

    Topics: Acetylcysteine; Acrolein; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Non-Smokers; Smoking Water Pipes; Tobacco Products; Tobacco Smoke Pollution; Tobacco, Waterpipe; Water Pipe Smoking; Young Adult

2018
Alda-1 Protects Against Acrolein-Induced Acute Lung Injury and Endothelial Barrier Dysfunction.
    American journal of respiratory cell and molecular biology, 2017, Volume: 57, Issue:6

    Topics: Acetylcysteine; Acrolein; Acute Lung Injury; AMP-Activated Protein Kinases; Animals; Benzamides; Benzodioxoles; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Male; Mice; Mitochondria; Oxygen Consumption

2017
Role of metabolites of cyclophosphamide in cardiotoxicity.
    BMC research notes, 2017, Aug-14, Volume: 10, Issue:1

    Topics: Acetylcysteine; Acrolein; Aldehyde Dehydrogenase; Animals; Apoptosis; Cardiotoxicity; Cardiotoxins; Cell Line; Cell Survival; Cyclophosphamide; Free Radical Scavengers; Immunosuppressive Agents; Myocytes, Cardiac; Phosphoramide Mustards; Rats; Reactive Oxygen Species

2017
Alterations in Acrolein Metabolism Contribute to Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 61, Issue:2

    Topics: Acetylcysteine; Acrolein; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Case-Control Studies; Creatinine; Disease Progression; Early Diagnosis; Female; Humans; Male; Middle Aged

2018
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: Acetylcysteine; Acrolein; Animals; Carcinoma, Lewis Lung; Isocitrate Dehydrogenase; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NADP; Oxidation-Reduction; Oxidative Stress; RNA, Small Interfering

2017
Protective Effects of Brain Infarction by
    Stroke, 2018, Volume: 49, Issue:7

    Topics: Acetylcysteine; Acrolein; Animals; Brain; Brain Infarction; Cell Line, Tumor; Disease Models, Animal; Glutathione; Mice; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species

2018
'Real-world' compensatory behaviour with low nicotine concentration e-liquid: subjective effects and nicotine, acrolein and formaldehyde exposure.
    Addiction (Abingdon, England), 2018, Volume: 113, Issue:10

    Topics: Acetylcysteine; Acrolein; Adult; Cotinine; Craving; England; Female; Formaldehyde; Formates; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nicotinic Agonists; Saliva; Substance Withdrawal Syndrome; Vaping; Young Adult

2018
Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Acetylcysteine; Acrolein; Acrylonitrile; Adult; Biomarkers; Cigarette Smoking; Female; Hazardous Substances; Humans; Longitudinal Studies; Male; Middle Aged; Randomized Controlled Trials as Topic; Smokers; Tobacco Products; Toxicology

2019
A biomonitoring assessment of secondhand exposures to electronic cigarette emissions.
    International journal of hygiene and environmental health, 2019, Volume: 222, Issue:5

    Topics: Acetylcysteine; Acrolein; Adult; Biomarkers; Cotinine; Electronic Nicotine Delivery Systems; Environmental Monitoring; Female; Humans; Male; Tobacco Smoke Pollution; Vaping

2019
Sustained Human Background Exposure to Acrolein Evidenced by Monitoring Urinary Exposure Biomarkers.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:24

    Topics: Acetylcysteine; Acrolein; Biomarkers; Cigarette Smoking; Cooking; Diet; Environmental Exposure; Female; Hot Temperature; Humans; Male

2019
Resolution and Quantitation of Mercapturic Acids Derived from Crotonaldehyde, Methacrolein, and Methyl Vinyl Ketone in the Urine of Smokers and Nonsmokers.
    Chemical research in toxicology, 2020, 02-17, Volume: 33, Issue:2

    Topics: Acetylcysteine; Acrolein; Aldehydes; Butanones; Humans; Molecular Structure; Non-Smokers; Smokers

2020
Quantification of 3-Hydroxypropyl Mercapturic Acid in the Urine of Patients with Breast Cancer to Monitor Cyclophosphamide Toxicity.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:4

    Topics: Acetylcysteine; Acrolein; Adult; Alkylating Agents; Biomarkers; Breast Neoplasms; Chromatography, Liquid; Cyclophosphamide; Female; Hematuria; Humans; Middle Aged; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2020
Combination Therapy with Cinnamaldehyde and Hyperthermia Induces Apoptosis of A549 Non-Small Cell Lung Carcinoma Cells via Regulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase Family.
    International journal of molecular sciences, 2020, Aug-28, Volume: 21, Issue:17

    Topics: A549 Cells; Acetylcysteine; Acrolein; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Cell Survival; Combined Modality Therapy; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Hyperthermia, Induced; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Signaling System; Phosphorylation; Reactive Oxygen Species

2020
N-acetylcysteine is more effective than ellagic acid in preventing acrolein induced dysfunction in mitochondria isolated from rat liver.
    Journal of food biochemistry, 2021, Volume: 45, Issue:7

    Topics: Acetylcysteine; Acrolein; Animals; Cell Survival; Ellagic Acid; Liver; Mitochondria; Rats

2021
Psychosocial impairment following mild blast-induced traumatic brain injury in rats.
    Behavioural brain research, 2021, 08-27, Volume: 412

    Topics: Acetylcysteine; Acrolein; Animals; Blast Injuries; Brain; Brain Concussion; Brain Injuries; Disease Models, Animal; Magnetic Resonance Imaging; Male; Prefrontal Cortex; Psychosocial Functioning; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate

2021
Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications.
    Toxicology and applied pharmacology, 2021, 09-01, Volume: 426

    Topics: Acetylcysteine; Acrolein; Animals; Aorta, Thoracic; Female; Glutathione S-Transferase pi; GTPase-Activating Proteins; Male; Mesenteric Artery, Superior; Mice, Inbred C57BL; Mice, Knockout; TRPA1 Cation Channel

2021
Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo.
    European journal of endocrinology, 2022, Oct-01, Volume: 187, Issue:4

    Topics: Acetylcysteine; Acrolein; Animals; Carnosine; Cytokines; Diabetes Mellitus; Diabetic Nephropathies; Environmental Pollutants; HEK293 Cells; Humans; Hydralazine; Kidney; Mice; Streptozocin

2022
Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products.
    Drug testing and analysis, 2023, Volume: 15, Issue:10

    Topics: Acetylcysteine; Acrolein; Acrylamides; Biomarkers; Carcinogens; Electronic Nicotine Delivery Systems; Humans; Nicotiana; Nicotine; Smoking Cessation; Tobacco Use Cessation Devices

2023
Global Profiling of Urinary Mercapturic Acids Using Integrated Library-Guided Analysis.
    Environmental science & technology, 2023, 07-25, Volume: 57, Issue:29

    Topics: Acetylcysteine; Acrolein; Biomarkers; Chromatography, Liquid; Humans; Tandem Mass Spectrometry

2023