acetylcysteine has been researched along with acetylleucyl-leucyl-norleucinal in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 26 (53.06) | 18.2507 |
| 2000's | 20 (40.82) | 29.6817 |
| 2010's | 2 (4.08) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Goldberg, AL; Jensen, TJ; Loo, MA; Pind, S; Riordan, JR; Williams, DB | 1 |
| Goldberg, AL; Grimm, LM; Osborne, BA; Poirier, GG; Schwartz, LM | 1 |
| Becherer, JD; Fernandez, PA; Irmler, M; Maki, M; Martinou, I; Martinou, JC; Quiquerez, AL; Sadoul, R; Schröter, M; Tschopp, J | 1 |
| Benham, A; Braud, V; Cerundolo, V; Gould, K; Macino, B; Mukherjee, S; Neefjes, J; Townsend, A | 1 |
| Cresswell, P; Hammond, C; Hughes, EA | 1 |
| Bush, KT; Goldberg, AL; Nigam, SK | 1 |
| Roberts, BJ | 1 |
| An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L | 1 |
| Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T | 1 |
| Bai, A; Forman, J | 1 |
| Celis, JE; Chen, HY; Davie, JR; Mimnaugh, EG; Neckers, L | 1 |
| Fischer, JE; Hasselgren, PO; Hobler, SC; Monaco, J; Tiao, G | 1 |
| Calautti, E; Di Cunto, F; Dotto, GP; Hsiao, J; Ong, L; Seth, PK; Topley, G | 1 |
| Adeli, K; Gapor, A; Theriault, A; Wang, Q | 1 |
| Colella, TA; Crotzer, VL; Engelhard, VH; Hunt, DF; King, GM; Luckey, CJ; Maier, BF; Marto, JA; Shabanowitz, J; Venketeswaran, S | 1 |
| Fang, CH; Fischer, JE; Hasselgren, PO; Hobler, S; Li, BG; Wang, JJ | 1 |
| Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN | 1 |
| Chrétien, S; Gisselbrecht, S; Lacombe, C; Mayeux, P; Muller, O; Varlet, P; Verdier, F; Yoshimura, A | 1 |
| Di Sano, F; Oliverio, S; Piacentini, M; Spinedi, A | 1 |
| Guerra, B; Lanford, RE; Wang, J; White, AL | 1 |
| Choi, YH; Henkart, PA; Hwang, SG; Jang, JS; Lee, J; Lee, SJ; Maki, M; Nguyen, PM; Takano, E; Trepel, JB; Wu, ML | 1 |
| Mulligan-Kehoe, MJ; Russo, A | 1 |
| Banks, L; Mantovani, F | 1 |
| Irie, S; Katagiri, K; Katagiri, T; Kawashima, S; Kinashi, T; Tanaka, K; Yokosawa, H | 1 |
| Boulaire, J; Cannella, D; Fitzgerald, P; Fotedar, A; Fotedar, R; Rousseau, D | 1 |
| Asakura, T; Hashizume, Y; Ohkawa, K; Okawa, Y; Sawai, T; Takada, K; Yanaihara, N | 1 |
| Higasa, T; Kito, M; Kusunose, M; Moriyama, T; Urade, R | 1 |
| Einarson, MB; Fashena, SJ; Golemis, EA; Law, SF; O'Neill, GM | 1 |
| An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB | 1 |
| French, OG; Hahn, CS; Kang, BS; Sando, JJ | 1 |
| Furuta, K; Hanada, S; Harada, M; Kawaguchi, T; Kim, M; Kimura, R; Koga, H; Sakisaka, S; Sata, M; Suganuma, T; Sugiyama, T; Taniguchi, E; Terada, K | 1 |
| Goldenberg, GJ; Lam, V; McPherson, JP; Salmena, L | 1 |
| Bence, NF; Kopito, RR; Sampat, RM | 1 |
| Drahushuk, KM; Guo, X; Higgins, D; Horbinski, C; Kaplan, PL; Kim, IJ; Lein, P; Lin, Y; Wang, T | 1 |
| Ikemoto, H; Kitagawa, H; Matsumoto, T; Tani, E | 1 |
| Burton, GR; Lyle, RE; May, JS; McGehee, RE; Prince, AM | 1 |
| Avraham, HK; Miralem, T | 1 |
| Aki, T; Mizukami, Y; Yoshida, K | 1 |
| Delvin, E; Lambert, M; Levy, E; Seidman, E; Ziv, E; Zoltowska, M | 1 |
| Chang, YC; Kwon, TK; Lim, JH; Park, JW; Park, YB | 1 |
| Allaman-Pillet, N; Billestrup, N; Bonny, C; Karlsen, AE; Mandrup-Poulsen, T; Størling, J | 1 |
| Gong, Q; Keeney, DR; Molinari, M; Zhou, Z | 1 |
| Inomata, M; Nakamura, M; Ohno, H; Shintani-Ishida, K; Uemura, K; Yoshida, K | 1 |
| Moir, RD; Myre, MA; Tanzi, RE; Tesco, G; Wasco, W; Washicosky, K | 1 |
| Adeli, K; Qiu, W; Rutledge, AC; Su, Q; Zhang, J | 1 |
| Amano, T; Kameyama, N; Mochizuki, H; Nobukuni, M; Okada, S; Sakai, N; Seki, T; Tanaka, A; Yamamoto, H | 1 |
| Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM | 1 |
| Ann, EJ; Kim, MY; Kim, SM; Mo, JS; Park, HS; Yoon, JH | 1 |
49 other study(ies) available for acetylcysteine and acetylleucyl-leucyl-norleucinal
| Article | Year |
|---|---|
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.
Topics: Acetylcysteine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endopeptidases; Endoplasmic Reticulum; Humans; Leupeptins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Ubiquitins | 1995 |
Proteasomes play an essential role in thymocyte apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; DNA Ligases; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; T-Lymphocytes | 1996 |
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
Topics: Acetylcysteine; Animals; Apoptosis; Calcium-Binding Proteins; Caspase 1; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Ligases; Electrophoresis, Polyacrylamide Gel; Leupeptins; Multienzyme Complexes; Nerve Growth Factors; Neurons; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Rats; Sympathetic Nervous System | 1996 |
The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells.
Topics: Acetylcysteine; Animals; Antigen-Presenting Cells; Antigens, Viral; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Epitopes; H-2 Antigens; Humans; Leupeptins; Mice; Multienzyme Complexes; Nucleocapsid Proteins; Nucleoproteins; Orthomyxoviridae; Peptides; Proteasome Endopeptidase Complex; Signal Transduction; T-Lymphocytes, Cytotoxic; Vaccinia virus; Viral Core Proteins | 1997 |
Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome.
Topics: Acetylcysteine; beta 2-Microglobulin; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Histocompatibility Antigens Class I; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Folding; Solubility; Transfection; Tumor Cells, Cultured | 1997 |
Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.
Topics: Acetylcysteine; Animals; Calpain; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Endoplasmic Reticulum; Fungal Proteins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Conformation; RNA, Messenger | 1997 |
Evidence of proteasome-mediated cytochrome P-450 degradation.
Topics: Acetylcysteine; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Leupeptins; Microsomes, Liver; Mixed Function Oxygenases; Multienzyme Complexes; Oxidoreductases, N-Demethylating; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 1997 |
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules.
Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cysteine Endopeptidases; Endoplasmic Reticulum; Epitopes; Hexosaminidases; Histocompatibility Antigens Class I; HLA-A2 Antigen; Humans; Leupeptins; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Sorting Signals; Self Tolerance; T-Lymphocytes, Cytotoxic | 1997 |
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response.
Topics: Acetylcysteine; Breast Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; DNA Replication; Female; Histones; Hot Temperature; Humans; Leupeptins; Multienzyme Complexes; Nucleoproteins; Nucleosomes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitins | 1997 |
Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors.
Topics: Acetylcysteine; Animals; Cecum; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Kinetics; Leupeptins; Male; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis; Transcription, Genetic; Ubiquitins | 1998 |
Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.
Topics: Acetylcysteine; Adenoviridae; Animals; Animals, Newborn; Cell Cycle; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Gene Expression Regulation; Keratinocytes; Leupeptins; Membrane Proteins; Mice; Mutation; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Succinates; Transfection | 1998 |
Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway.
Topics: Acetylcysteine; Apolipoproteins B; Biological Transport; Cell Membrane Permeability; Chromans; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leupeptins; Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Tumor Cells, Cultured; Vitamin E | 1998 |
Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell-Free System; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Glycine; Histocompatibility Antigens Class I; HLA-A Antigens; Humans; Leupeptins; Membrane Proteins; Mice; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Time Factors; Viral Matrix Proteins | 1998 |
Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats.
Topics: Acetylcysteine; Animals; Burns; Culture Techniques; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Lactones; Leupeptins; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tyrosine; Ubiquitins | 1998 |
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats | 1998 |
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Immediate-Early Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Receptors, Erythropoietin; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Tyrosine; Ubiquitins | 1998 |
Calpain involvement in calphostin C-induced apoptosis.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Calpain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Naphthalenes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; U937 Cells; Ubiquitins | 1998 |
Presecretory degradation of apolipoprotein [a] is mediated by the proteasome pathway.
Topics: Acetylcysteine; Animals; Apolipoproteins A; Calnexin; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fabaceae; Hepatocytes; Hexosaminidases; Leupeptins; Mannosidases; Molecular Chaperones; Multienzyme Complexes; Papio; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Transfection; Ubiquitin | 1999 |
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Bucladesine; Calpain; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Dipeptides; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketones; Leupeptins; Lovastatin; Nuclear Proteins; Protein Processing, Post-Translational; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Tumor Cells, Cultured | 1999 |
Inhibition of cytoplasmic antigen, glucose- 6-phosphate dehydrogenase, by VH-CH1, an intracellular Fd fragment antibody derived from a semisynthetic Fd fragment phage display library.
Topics: Acetylcysteine; Animals; Cell Line; Cricetinae; Cricetulus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Inovirus; Isopropyl Thiogalactoside; Kinetics; Leupeptins; Multienzyme Complexes; Peptide Library; Proteasome Endopeptidase Complex; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 1999 |
Inhibition of E6 induced degradation of p53 is not sufficient for stabilization of p53 protein in cervical tumour derived cell lines.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; Female; Fibrosarcoma; Humans; Leupeptins; Mitomycin; Oncogene Proteins, Viral; Papillomaviridae; Polymorphism, Genetic; Repressor Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 1999 |
Ubiquitin-proteasome system is involved in induction of LFA-1/ICAM-1-dependent adhesion of HL-60 cells.
Topics: Acetylcysteine; Adenosine Triphosphatases; Antibody Affinity; Cell Adhesion; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; HL-60 Cells; Humans; Intercellular Adhesion Molecule-1; Leupeptins; Lymphocyte Function-Associated Antigen-1; Monocytes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tetradecanoylphorbol Acetate; Tretinoin; Ubiquitins | 1999 |
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Hemagglutinins; Humans; Leupeptins; Mice; Models, Genetic; Multienzyme Complexes; Mutagenesis; Osteosarcoma; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitins | 1999 |
Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover.
Topics: Acetylcysteine; Ammonium Chloride; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brefeldin A; Calpain; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; K562 Cells; Leucine; Leupeptins; Membrane Proteins; Protein Synthesis Inhibitors; Time Factors; Ubiquitins | 1999 |
Accumulation and degradation in the endoplasmic reticulum of a truncated ER-60 devoid of C-terminal amino acid residues.
Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; Calreticulin; Carrier Proteins; Cell Membrane; COS Cells; Culture Media; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochalasin B; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Half-Life; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Proteins; Molecular Chaperones; Protein Disulfide-Isomerases; Recombinant Proteins; Ribonucleoproteins | 2000 |
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Caspase 3; Caspase 7; Caspase Inhibitors; Caspases; Cell Death; Crk-Associated Substrate Protein; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Mitosis; Multienzyme Complexes; Mutation; Oligopeptides; Peptide Fragments; Phosphoproteins; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Isoforms; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells | 2000 |
Activation-dependent degradation of protein kinase C eta.
Topics: Acetylcysteine; Animals; Cell Fractionation; Cell Line; Chick Embryo; Cricetinae; Cysteine Endopeptidases; Detergents; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Humans; Isoenzymes; Kidney; Leupeptins; Membrane Proteins; Mesocricetus; Mice; Multienzyme Complexes; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Protein Conformation; Protein Kinase C; Protein Kinase C-theta; Rats; Recombinant Fusion Proteins; Sindbis Virus; Tumor Cells, Cultured; Ubiquitins | 2000 |
A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.
Topics: Acetylcysteine; Adenosine Triphosphatases; Carrier Proteins; Cation Transport Proteins; Cell Line; Copper-Transporting ATPases; Cysteine Endopeptidases; Cytoskeleton; Fluorescent Antibody Technique; Humans; Leupeptins; Microscopy, Confocal; Microscopy, Electron; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; Tissue Distribution | 2001 |
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.
Topics: Acetylcysteine; Adenosine Triphosphate; Antigens, Neoplasm; Cell Cycle; Cell Extracts; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; HeLa Cells; Humans; Isoenzymes; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2001 |
Impairment of the ubiquitin-proteasome system by protein aggregation.
Topics: Acetylcysteine; Amino Acid Sequence; Cell Death; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; G2 Phase; Green Fluorescent Proteins; Humans; Huntingtin Protein; Inclusion Bodies; Leupeptins; Luminescent Proteins; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Nuclear Proteins; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.
Topics: Acetylcysteine; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dendrites; DNA-Binding Proteins; Gene Expression; Leupeptins; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Smad Proteins; Smad1 Protein; Superior Cervical Ganglion; Trans-Activators; Transcriptional Activation; Transfection; Transforming Growth Factor beta | 2001 |
Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells.
Topics: Acetylcysteine; Apoptosis; Base Sequence; Brain Neoplasms; Cysteine Proteinase Inhibitors; DNA Primers; Fas Ligand Protein; fas Receptor; Glioma; Humans; Leupeptins; Membrane Glycoproteins; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured | 2001 |
Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.
Topics: Acetylcysteine; Adipocytes; Animals; Calpain; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Nuclear Proteins; Peptide Hydrolases; Phosphoproteins; Proteasome Endopeptidase Complex; Proteins; Retinoblastoma-Like Protein p130 | 2002 |
Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.
Topics: Acetylcysteine; Blotting, Northern; Blotting, Western; BRCA1 Protein; Cell Cycle; Cell Division; Cell Survival; Collagen; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Combinations; Enzyme Inhibitors; Extracellular Matrix; Genetic Vectors; Germ-Line Mutation; Humans; Immunoblotting; Laminin; Leupeptins; MAP Kinase Signaling System; Neuregulin-1; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Polylysine; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteoglycans; Proto-Oncogene Proteins; Receptor, ErbB-2; RNA; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
The mechanism of alphaB-crystallin gene expression by proteasome inhibition.
Topics: Acetylcysteine; alpha-Crystallin B Chain; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Heat-Shock Response; Leupeptins; Multienzyme Complexes; Myocytes, Cardiac; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Rats | 2003 |
Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly.
Topics: Acetylcysteine; Animals; Apolipoproteins B; Cells, Cultured; Cysteine Endopeptidases; Diabetes Mellitus; Disease Models, Animal; Gerbillinae; Hepatocytes; Hypercholesterolemia; Hyperinsulinism; Hypertriglyceridemia; Insulin; Insulin Resistance; Leupeptins; Lipoproteins, VLDL; Liver; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex | 2004 |
Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.
Topics: Acetylcysteine; Antioxidants; Cell Cycle Proteins; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; Glutathione; Humans; Leupeptins; Multienzyme Complexes; Osteosarcoma; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Insulinoma; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Pancreatic Neoplasms; Proteasome Inhibitors; Rats; Signal Transduction; Tumor Suppressor Protein p53 | 2005 |
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Alkaloids; Blotting, Western; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Leupeptins; Long QT Syndrome; Mutation; Potassium Channels; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ribonucleases; Subcellular Fractions; Time Factors; Transfection; Ubiquitin | 2005 |
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.
Topics: Acetylcysteine; Calpain; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cell Death; Cell Line, Tumor; Delta Catenin; Dipeptides; Humans; Ischemia; Leupeptins; Neuroblastoma; Phosphoproteins | 2007 |
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzazepines; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclin D1; Fibroblasts; Glioma; Hexanones; Humans; Hydrocarbons, Chlorinated; Indoles; Leupeptins; Mice; Peptide Fragments; Proteasome Inhibitors; Purines; Recombinant Fusion Proteins; Roscovitine; Threonine | 2009 |
Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.
Topics: Acetylcysteine; Activating Transcription Factor 6; Animals; Apolipoprotein B-100; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoribonucleases; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Glucosamine; Heat-Shock Proteins; Humans; Leupeptins; Membrane Proteins; Phosphorylation; Protein Serine-Threonine Kinases; RNA; Signal Transduction; Time Factors | 2009 |
The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.
Topics: Acetylcysteine; Animals; Binding Sites; Brefeldin A; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylation; Leupeptins; Membrane Transport Modulators; Protein Structure, Tertiary; Protein Transport; Quinones; Sequence Deletion; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sesquiterpenes; Structure-Activity Relationship; Transfection | 2009 |
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin | 2011 |
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.
Topics: Acetylcysteine; Ammonium Chloride; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Gene Knockout Techniques; HEK293 Cells; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leupeptins; Lysosomes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Presenilin-1; Presenilin-2; Proteasome Inhibitors; Proteolysis; Receptor, Notch1; Transcription, Genetic; Transcriptional Activation; Ubiquitination | 2012 |