Compounds > acetylcysteine

acetylcysteine and 4-hydroxy-2-nonenal

acetylcysteine has been researched along with 4-hydroxy-2-nonenal in 81 studies

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (7.41)18.2507
2000's44 (54.32)29.6817
2010's30 (37.04)24.3611
2020's1 (1.23)2.80

Authors

AuthorsStudies
Stadtman, ER; Uchida, K2
Grune, T; Petras, T; Siems, WG1
Fukuda, A; Hitomi, K; Osawa, T; Uchida, K1
Furukawa, F; Hasegawa, R; Inoue, T; Kurokawa, Y; Nishikawa, A; Sai-Kato, K; Toyokuni, S; Uchida, K; Umemura, T1
Erçal, N; Frank, RL; Matthews, RH; Yildiz, D1
Garrido, R; Hennig, B; Malecki, A; Mattson, MP; Toborek, M1
Huang, FF; Keller, JN; Markesbery, WR1
Amaranth, V; Montine, KS; Montine, TJ; Morales, CR; Neely, MD; Ou, JJ; Picklo, MJ; Zimmerman, L1
Benedict, CR; Katagiri, T; Pakala, R; Watanabe, T4
Koh, YH; Park, YS; Suzuki, K; Takahashi, M; Taniguchi, N1
Bermak, J; Weingarten, P; Zhou, QY1
Anan, I; Ando, Y; El-Salhy, M; Holmgren, G; Lång, K; Suhr, OB; Tashima, K; Wikström, L1
Bravo, E; Cantafora, A; Napolitano, M; Rivabene, R1
Anuradha, CD; Hirano, S; Kanno, S1
Dobashi, K; Ishizuka, T; Kawata, T; Mori, M; Shimizu, Y; Tsukagoshi, H1
Amarnath, V; Montine, KS; Montine, TJ; Olsen, SJ; Picklo, MJ; Sidell, KR1
Hoff, HF; Hoppe, G; O'Neil, J; Salomon, RL; Wu, Z1
Alary, J; Debrauwer, L; Fernandez, Y; Guéraud, F; Perdu, E1
Irie, K; Maru, Y; Muraki, T; Ohba, K; Uchida, Y; Yoshioka, T1
Liang, JN; Marques, C; Pereira, P; Reddy, VN; Shang, F; Szweda, LI; Taylor, A1
Andreadou, I; Bofilis, E; Constantinou, M; Iliodromitis, EK; Kremastinos, DT; Mikros, E; Tsantili-Kakoulidou, A; Zoga, A1
Andreoni, S; Appollonio, I; Begni, B; Beretta, S; Brighina, L; Ferrarese, C; Fumagalli, L; Isella, V; Malaplate-Armand, C; Oster, T; Sirtori, E1
Alary, J; Debrauwer, L; Guéraud, F; Martins, N; Peiro, G; Rathahao, E1
Alvarez-Sánchez, R; Dekant, W; Mally, A; Pähler, A; Völkel, W; Weick, I1
Albano, E; Badger, TM; Butura, A; Ingelman-Sundberg, M; Korourian, S; Petersen, DR; Prior, RL; Ronis, MJ; Sampey, BP; Shankar, K1
Halliwell, B; Hyun, DH; Jenner, P; Lee, M1
Kim, CH; Kwon, TK; Lee, JT; Lee, TJ; Moon, SK; Park, JW1
Alary, J; Bernard, H; Bories, G; Canlet, C; Créminon, C; Debrauwer, L; Drumare, MF; Guéraud, F; Peiro, G; Rathahao, E; Wal, JM1
Alary, J; Cravedi, JP; Guéraud, F; Peiro, G; Rathahao, E; Steghens, JP1
Alary, J; Cravedi, JP; Crouzet, F; Debrauwer, L; Guéraud, F; Laurent, F; Rao, D1
Cottalasso, D; Furfaro, AL; Marinari, UM; Menini, S; Odetti, P; Patriarca, S; Pesce, C; Pronzato, MA; Traverso, N1
Arakawa, M; Ishige, K; Ito, Y; Oda, T; Osada, N; Ushimaru, N1
Bates, KA; Harvey, AR; Martins, RN1
Carpenter, AB; Kiningham, KK; Sullivan, SB; Terneus, MV; Valentovic, MA1
Arai, Y; Arakawa, M; Ishige, K; Ishimura, A; Ito, Y; Kawabe, K; Suzuki, S1
Arakawa, M; Ito, Y1
Cheung, NS; Halliwell, B; Koh, CH; Li, QT; Manikandan, J; Melendez, AJ; Peng, ZF; Tang, SY1
Brown, JM; Carpenter, AB; Terneus, MV; Valentovic, MA1
Kuiper, HC; Miranda, CL; Sowell, JD; Stevens, JF1
Aoki, R; Numazawa, S; Sakaguchi, H; Taira, T; Yoshida, T1
Annangudi, SP; Crabb, JW; Deng, Y; Gu, X; Salomon, RG; Zhang, W1
Gavin, T; Geohagen, BC; Lopachin, RM1
Couture, R; de Champlain, J; El Midaoui, A; Fantus, IG; Ismael, MA; Lu, H1
Augé, N; Bando, Y; Marachet, MA; Muller, C; Nègre-Salvayre, A; Salvayre, R; Sanson, M; Sawa, Y; Thiers, JC; Vindis, C; Zarkovic, K1
Jeong, E; Kim, SY; Kim, YS; Lee, JY; Park, ZY1
Biasi, F; Brocato, L; Dinatale, S; Martina, V; Mascia, C; Masha, A1
Joss, J; Jubert, C; Kuiper, HC; Langsdorf, BL; Mata, JE; Miranda, CL; Stevens, JF1
Malter, JS; Wang, DS; Wang, R1
Ahmed, M; Girnun, GD; Goldberg, SN; Levchenko, T; Rahmanuddin, S; Schor-Bardach, R; Signoretti, S; Solazzo, SA; Spitz, DR; Torchilin, V; Yang, W1
Unger, EC1
Crum, A; Norris, KC; Paul Lee, WN; Shen, R; Sinha-Hikim, I; Vaziri, ND1
Capuozzo, E; Crifo, C; Grune, T; Salerno, C; Siems, W; Uchida, K1
Fukushima, M; Hara, R; Inatani, M; Inomata, Y; Kawaji, T; Sagara, N; Tanihara, H1
Gao, G; Kowluru, R; Lee, K; Lyons, TJ; Ma, JX; Zhou, KK; Zhou, T1
Chang, YS; Kanagawa, T; Kimura, T; Nakai, Y; Nakamura, T; Shimoya, K; Temma-Asano, K; Tomimatsu, T; Tskitishvili, E; Tsutsui, T1
Asano, N; Iijima, K; Kato, K; Kusaka, G; Shimosegawa, T; Uno, K1
Awasthi, S; Awasthi, YC; Chaudhary, P; Kokate, RA; Kumar, S; Sahu, M; Sharma, R1
Abuladze, N; Bragin, A; Cascio, D; Damoiseaux, R; Faull, K; Pushkin, A; Schibler, MJ; Tsirulnikov, K1
Cindric, M; Cipak, A; Jaganjac, M; Milkovic, L; Stolc, S; Suzana Borovic, S; Waeg, G; Zapletal, E; Zarkovic, N1
Dou, X; Gu, D; Li, S; Shen, C; Song, Z; Wang, Z; Yao, T1
Chang, H; Jo, SA; Kim, BS; Kim, YI; Kwon, DH; Leem, YH1
Kothari, H; Pendurthi, UR; Rao, LV; Vatsyayan, R1
Henao, F; Hortigón-Vinagre, MP1
Fukui, M; Miyamoto, R; Nomura, S; Shimakawa, S; Tamai, H1
Bollineli, RC; Marques, MJ; Minatel, E; Mizobuti, DS; Moraes, LH; Silveira, Ldos R1
Baradat, M; Debrauwer, L; Guéraud, F; Jouanin, I; Keller, J1
Chen, J; Hill, K; Lemasters, J; Sha, SH; Wang, X; Yang, SM; Yuan, H1
Amboni, RT; Arent, CO; Bianchini, G; Dal-Pont, GC; Lopes-Borges, J; Quevedo, J; Resende, WR; Steckert, AV; Valvassori, SS1
Chen, L; Ge, L; Liu, Z; Ma, JX; Zhou, J; Zhou, T; Zhou, Y; Zong, R1
Andrades, M; Biolo, A; Clausell, N; Cohen, C; Dal-Pizzol, F; Lopes, A; Martinelli, N; Olsen, V; Phaelante, A; Rohde, LE; Tobar, SA1
Arimon, M; Berezovska, O; Hyman, BT; Post, KL; Svirsky, S; Takeda, S1
Aykin-Burns, N; Banerjee, S; Hauer-Jensen, M; Krager, KJ; Melnyk, SB; Pawar, SA; Shah, SK1
Dai, Z; Ji, Y; Wu, G; Wu, Z1
El-Kabbani, O; Endo, S; Ikari, A; Kamata, K; Matsunaga, T; Miyazono, H; Morikawa, Y; Sasajima, Y; Sato, K; Shibata, A; Suenami, K; Takekoshi, Y1
Chan, J; Goldsborough, K; Harvey, VM; Mantel, A; McDonald, JT1
Ahmed, J; Eshraghi, AA; Gupta, C; Ila, K; Mittal, J; Tillinger, JA; Van De Water, TR1
Chan, JTW; Chen, C; Chen, R; Chung, SK; Huang, B; Law, BYK; Li, Z; Luo, W; Mok, SWF; Ng, JPL; Qu, L; Qu, Y; Su, L; Wang, L; Wang, X; Wang, Y; Wong, VKW; Xu, X; Yang, J; Yang, L; Yun, X; Zeng, Y; Zhang, W1

Reviews

2 review(s) available for acetylcysteine and 4-hydroxy-2-nonenal

ArticleYear
N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology.
    Cerebellum (London, England), 2007, Volume: 6, Issue:4

    Topics: Acetylcysteine; Aldehydes; Central Nervous System Diseases; Cerebellum; Free Radical Scavengers; Humans; Neurodegenerative Diseases; Neurons; Reactive Oxygen Species

2007
Inhibition of mercapturic acid pathway-mediated disposal of 4-hydroxynonenal causes complete and sustained remission of human cancer xenografts in nude mice.
    Indian journal of experimental biology, 2011, Volume: 49, Issue:11

    Topics: Acetylcysteine; Aldehydes; Animals; ATP-Binding Cassette Transporters; Carcinogens, Environmental; Chemoprevention; Glutathione Transferase; GTPase-Activating Proteins; Humans; Metabolic Networks and Pathways; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Remission Induction; Xenobiotics

2011

Other Studies

79 other study(ies) available for acetylcysteine and 4-hydroxy-2-nonenal

ArticleYear
Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Jun-15, Volume: 89, Issue:12

    Topics: Acetylcysteine; Aldehydes; Borohydrides; Chromatography, High Pressure Liquid; Enzymes; Glutathione; Models, Chemical; Protein Binding; Proteins; Radioisotope Dilution Technique; Tritium

1992
Quantitation of 4-hydroxynonenal protein adducts.
    Methods in enzymology, 1994, Volume: 233

    Topics: Acetylcysteine; Aldehydes; Chromatography, High Pressure Liquid; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Indicators and Reagents; Lipid Peroxidation; Lysine; Protein Binding; Proteins; Radioisotope Dilution Technique; Tritium

1994
4-hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney.
    Free radical biology & medicine, 1995, Volume: 19, Issue:5

    Topics: Acetylcysteine; Aldehydes; Animals; Inactivation, Metabolic; Kidney; Kinetics; Lipid Peroxidation; Male; Perfusion; Rats; Rats, Wistar; Time Factors

1995
4-Hydroxy-2-nonenal cytotoxicity in renal proximal tubular cells: protein modification and redox alteration.
    Archives of biochemistry and biophysics, 1996, Sep-15, Volume: 333, Issue:2

    Topics: Acetylcysteine; Aldehydes; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cell-Free System; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules, Proximal; Kinetics; Muscle, Skeletal; Oxidation-Reduction; Proteins; Rabbits; Rats; Time Factors

1996
Prevention by 2-mercaptoethane sulfonate and N-acetylcysteine of renal oxidative damage in rats treated with ferric nitrilotriacetate.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Aldehydes; Animals; Antioxidants; Carcinogens; Deoxyguanosine; DNA; DNA Damage; Ferric Compounds; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Mesna; Nitrilotriacetic Acid; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances

1996
Effects of 4-hydroxynonenal and N-acetyl-L-cysteine on Myc-induced apoptosis.
    Toxicology letters, 1996, Dec-31, Volume: 89, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Cell Count; Cell Division; Cells, Cultured; Cross-Linking Reagents; Culture Media, Serum-Free; DNA; Electrophoresis, Agar Gel; Proto-Oncogene Proteins c-myc; Rats

1996
4-Hydroxynonenal induces oxidative stress and death of cultured spinal cord neurons.
    Journal of neurochemistry, 2000, Volume: 74, Issue:6

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Azoles; Calcium; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA Fragmentation; Fetus; Isoindoles; Lipid Peroxidation; Mice; Neurons; Organoselenium Compounds; Oxidative Stress; Spinal Cord

2000
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
    Neuroscience, 2000, Volume: 98, Issue:1

    Topics: Acetylcysteine; Aging; Aldehydes; Amino Acid Chloromethyl Ketones; Animals; Cell Death; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glutathione; Iron; Lipid Peroxidation; Lysosomes; Mice; Motor Neurons; Multienzyme Complexes; Neuroblastoma; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reactive Oxygen Species; Spinal Cord; Tumor Cells, Cultured

2000
Congeners of N(alpha)-acetyl-L-cysteine but not aminoguanidine act as neuroprotectants from the lipid peroxidation product 4-hydroxy-2-nonenal.
    Free radical biology & medicine, 2000, Nov-15, Volume: 29, Issue:10

    Topics: Acetylcysteine; Aldehydes; Animals; Brain; Cell Line; Free Radical Scavengers; Guanidines; In Vitro Techniques; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mitochondria; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2000
Lipid peroxidation product 4-hydroxy-2-nonenal acts synergistically with serotonin in inducing vascular smooth muscle cell proliferation.
    Atherosclerosis, 2001, Volume: 155, Issue:1

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Aorta, Thoracic; Arteriosclerosis; Ascorbic Acid; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Drug Synergism; Hydroquinones; Indoles; Lipid Peroxidation; Lysergic Acid; Male; Mitogens; Muscle, Smooth, Vascular; Pertussis Toxin; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Serotonin; Serotonin Antagonists; Virulence Factors, Bordetella; Vitamin E

2001
Aldehyde reductase gene expression by lipid peroxidation end products, MDA and HNE.
    Free radical research, 2000, Volume: 33, Issue:6

    Topics: Acetylcysteine; Aldehyde Reductase; Aldehydes; Animals; Aorta; Calcium; Cells, Cultured; Enzyme Induction; Gene Expression; Lipid Peroxidation; Malondialdehyde; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar

2000
Evidence for non-oxidative dopamine cytotoxicity: potent activation of NF-kappa B and lack of protection by anti-oxidants.
    Journal of neurochemistry, 2001, Volume: 76, Issue:6

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Aromatic-L-Amino-Acid Decarboxylases; Aspirin; Cell Survival; CHO Cells; Clone Cells; Cricetinae; Dopamine; Glutathione; L-Lactate Dehydrogenase; Levodopa; Lipid Peroxidation; Malondialdehyde; NF-kappa B; Recombinant Proteins

2001
Scavenger treatment of free radical injury in familial amyloidotic polyneuropathy: a study on Swedish transplanted and non-transplanted patients.
    Scandinavian journal of clinical and laboratory investigation, 2001, Volume: 61, Issue:1

    Topics: Acetylcysteine; Adult; Aged; Aldehydes; Amyloid; Amyloid Neuropathies; Ascorbic Acid; Biopsy; Body Mass Index; Female; Free Radical Scavengers; Free Radicals; Humans; Immunohistochemistry; Lipid Peroxidation; Liver Transplantation; Male; Middle Aged; Nutritional Status; Oxidative Stress; Sweden; Treatment Outcome; Vitamin E

2001
Redox-dependent modulation of lipid synthesis induced by oleic acid in the human intestinal epithelial cell line Caco-2.
    Experimental biology and medicine (Maywood, N.J.), 2001, Volume: 226, Issue:3

    Topics: Acetylcysteine; Aldehydes; Antioxidants; Caco-2 Cells; Copper Sulfate; Glutathione; Glutathione Disulfide; Humans; Intestinal Mucosa; Lipids; Malondialdehyde; Oleic Acids; Oxidants; Oxidation-Reduction

2001
Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.
    Journal of hypertension, 2001, Volume: 19, Issue:6

    Topics: Acetylcysteine; Aldehydes; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Cell Division; Cells, Cultured; DNA; Drug Synergism; Flavonoids; Humans; Hydrogen Peroxide; Lipoproteins, LDL; Lysophosphatidylcholines; Muscle, Smooth, Vascular; Probucol; Rabbits; Receptor, Angiotensin, Type 1; Tetrazoles; Tyrphostins

2001
Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells.
    Circulation, 2001, Jul-03, Volume: 104, Issue:1

    Topics: Acetylcysteine; Aldehydes; Animals; Antibodies; Cell Division; Cells, Cultured; CSK Tyrosine-Protein Kinase; DNA; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Hydrogen Peroxide; Lipoproteins, LDL; Lysophosphatidylcholines; Male; Muscle, Smooth, Vascular; Oxidation-Reduction; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; src-Family Kinases; Thymidine; Urotensins

2001
Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells.
    Free radical biology & medicine, 2001, Aug-01, Volume: 31, Issue:3

    Topics: Acetylcysteine; Aldehydes; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Glutathione; HL-60 Cells; Humans; Lipid Peroxidation; Lipid Peroxides; Malondialdehyde; Mitochondria; Oxidative Stress; Sodium Fluoride

2001
Lysophosphatidylcholine is a major contributor to the synergistic effect of mildly oxidized low-density lipoprotein with endothelin-1 on vascular smooth muscle cell proliferation.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Aorta, Thoracic; Cell Count; Cell Division; Cells, Cultured; DNA; Endothelin Receptor Antagonists; Endothelin-1; Flavonoids; Free Radical Scavengers; Growth Inhibitors; Hydrogen Peroxide; Lipoproteins, LDL; Lysophosphatidylcholines; Male; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; NADPH Oxidases; Onium Compounds; Oxidants; Peptides, Cyclic; Rabbits; Reactive Oxygen Species

2002
4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway.
    Toxicology and applied pharmacology, 2002, Nov-01, Volume: 184, Issue:3

    Topics: Acetylcysteine; Aldehydes; Cell Line; Culture Media, Conditioned; ErbB Receptors; Fibroblasts; Fibronectins; Humans; Imidazoles; Lipid Peroxidation; Lung; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pyridines; Quinazolines; Signal Transduction; Tyrphostins

2002
Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum.
    Journal of neuropathology and experimental neurology, 2003, Volume: 62, Issue:2

    Topics: Acetylcysteine; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Fatty Acids, Unsaturated; Glutathione Transferase; Humans; Immunohistochemistry; Lipid Peroxidation; Male; Neurons; Oxidative Stress; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptosomes

2003
Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Feb-01, Volume: 23, Issue:2

    Topics: Acetylcysteine; Aldehydes; Animals; Arteriosclerosis; Biological Transport; Cathepsin B; Cholesterol Esters; Chromatography, Liquid; Humans; Intracellular Membranes; Lipoproteins, LDL; Lysine; Lysosomes; Macrophages, Peritoneal; Mice; Oxidation-Reduction; Phosphatidylcholines; Phospholipids; Pyrroles; Spectrometry, Mass, Electrospray Ionization

2003
Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat.
    Chemical research in toxicology, 2003, Volume: 16, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Chromatography, High Pressure Liquid; Cytosol; Gas Chromatography-Mass Spectrometry; Glutathione; Hydroxylation; Kidney; Lactones; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Sulfides; Tritium

2003
Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway.
    The Journal of biological chemistry, 2004, Feb-06, Volume: 279, Issue:6

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Adipocytes; Aldehydes; Animals; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Free Radical Scavengers; Glycation End Products, Advanced; Lipid Peroxidation; Male; NF-kappa B; Oxidative Stress; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred OLETF; Reactive Oxygen Species; RNA, Messenger; Up-Regulation

2004
Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:12

    Topics: Acetylcysteine; Adenosine Triphosphate; Aldehydes; alpha-Crystallin B Chain; Cell-Free System; Cells, Cultured; Epithelial Cells; Humans; Lens, Crystalline; Leupeptins; Lysosomes; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ubiquitin

2004
Melatonin does not prevent the protection of ischemic preconditioning in vivo despite its antioxidant effect against oxidative stress.
    Free radical biology & medicine, 2004, Aug-15, Volume: 37, Issue:4

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Free Radicals; Ischemic Preconditioning; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Malondialdehyde; Melatonin; Models, Statistical; Oxidative Stress; Rabbits; Reperfusion Injury; Superoxide Dismutase; Time Factors

2004
Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease.
    Free radical biology & medicine, 2004, Sep-15, Volume: 37, Issue:6

    Topics: Acetylcysteine; Adenosine Triphosphate; Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Animals; Antioxidants; Case-Control Studies; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fibroblasts; Free Radicals; Glutamic Acid; Glutathione; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors

2004
Liquid chromatography-multistage tandem mass spectrometry for the quantification of dihydroxynonene mercapturic acid (DHN-MA), a urinary end-metabolite of 4-hydroxynonenal.
    Analytical and bioanalytical chemistry, 2005, Volume: 381, Issue:8

    Topics: Acetylcysteine; Aldehydes; Animals; Chromatography, Liquid; Deuterium; Linear Models; Male; Mass Spectrometry; Rats; Rats, Wistar; Sensitivity and Specificity

2005
Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats.
    Free radical biology & medicine, 2005, Jun-01, Volume: 38, Issue:11

    Topics: Acetylcysteine; Aldehydes; Animals; Biomarkers; Free Radicals; Glutathione; Hepatocytes; Lipid Peroxidation; Liver; Male; Models, Chemical; Oxidative Stress; Rats; Rats, Inbred F344; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Time Factors

2005
Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition.
    Free radical biology & medicine, 2005, Sep-01, Volume: 39, Issue:5

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Cattle; Central Nervous System Depressants; Cytochrome P-450 CYP2E1; Cytokines; Cytosol; Enteral Nutrition; Ethanol; Glutathione; Immune System; Immunohistochemistry; Inflammation; Kupffer Cells; Lipid Peroxidation; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver; Lymphotoxin-alpha; Male; Malondialdehyde; Necrosis; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha

2005
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
    Journal of neuroscience research, 2005, Oct-15, Volume: 82, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases

2005
Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells.
    International journal of molecular medicine, 2006, Volume: 17, Issue:1

    Topics: Acetylcysteine; Age Factors; Aging; Aldehydes; Animals; Aorta; Cell Cycle; Cell Death; Cell Proliferation; Cells, Cultured; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Growth Inhibitors; MAP Kinase Signaling System; Mice; Myocytes, Smooth Muscle; Reactive Oxygen Species

2006
Enzyme immunoassay for a urinary metabolite of 4-hydroxynonenal as a marker of lipid peroxidation.
    Free radical biology & medicine, 2006, Jan-01, Volume: 40, Issue:1

    Topics: Acetylcysteine; Aldehydes; Alkenes; Animals; Biomarkers; Bromotrichloromethane; Chromatography, Liquid; Cross Reactions; Free Radicals; Immunoenzyme Techniques; Lipid Peroxidation; Male; Rabbits; Rats; Rats, Wistar; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trinitrobenzenesulfonic Acid

2006
Dihydroxynonene mercapturic acid, a urinary metabolite of 4-hydroxynonenal, as a biomarker of lipid peroxidation.
    BioFactors (Oxford, England), 2005, Volume: 24, Issue:1-4

    Topics: Acetylcysteine; Aldehydes; Animals; Biomarkers; Bromotrichloromethane; Chromatography, Liquid; Dinoprost; Kinetics; Lipid Peroxidation; Male; Malondialdehyde; Mass Spectrometry; Oxidative Stress; Rats; Rats, Wistar

2005
Enantioselective metabolism of (R)- and (S)-4-hydroxy-2-nonenal in rat.
    BioFactors (Oxford, England), 2005, Volume: 24, Issue:1-4

    Topics: Acetylcysteine; Aldehydes; Animals; Chromatography, High Pressure Liquid; Cytosol; Glutathione; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Spectrometry, Mass, Fast Atom Bombardment; Stereoisomerism; Structure-Activity Relationship; Tritium

2005
HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.
    BioFactors (Oxford, England), 2005, Volume: 24, Issue:1-4

    Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Cell Division; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Hydroxyethylrutoside; Immunohistochemistry; Kidney Glomerulus; Lipid Peroxidation; Lysine; Male; Rats; Rats, Wistar; Taurine

2005
N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death.
    Neuroscience research, 2006, Volume: 55, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Animals, Newborn; Antioxidants; Brain; Cell Death; Cells, Cultured; Cerebellum; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Mitochondrial Membranes; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar

2006
Oxidative stress in a rat model of chronic gliosis.
    Neurobiology of aging, 2007, Volume: 28, Issue:7

    Topics: Acetylcysteine; Aldehydes; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cells, Cultured; Chronic Disease; Disease Models, Animal; Embryo, Mammalian; Fetal Tissue Transplantation; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Gliosis; Ibuprofen; Lipid Peroxidation; Oxidative Stress; Protein Carbonylation; Rats; Time Factors

2007
Comparison of S-Adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Aldehydes; Animals; Antidotes; Blotting, Western; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL; Organ Size; Protein Carbonylation; S-Adenosylmethionine

2007
N-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.
    Neuroscience research, 2007, Volume: 57, Issue:2

    Topics: Acetylcysteine; Aldehydes; Animals; Animals, Newborn; Azoles; Calcium; Cell Death; Cells, Cultured; Cerebellum; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Isoindoles; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Nifedipine; Organoselenium Compounds; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors

2007
Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons: transcriptional responses and cellular pathways.
    Neuropharmacology, 2007, Volume: 53, Issue:5

    Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Calpain; Caspases; Cell Cycle Proteins; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytoskeleton; Free Radical Scavengers; Gene Expression Regulation; Genes, p53; Mice; Microarray Analysis; Neurons; Oxidative Stress; Signal Transduction; Transcription, Genetic; Ubiquitin

2007
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose.
    Toxicology, 2008, Feb-03, Volume: 244, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aldehydes; Analysis of Variance; Animals; Blotting, Western; Drug Overdose; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Microscopy, Polarization; Organ Size; Protein Carbonylation; S-Adenosylmethionine; Time Factors

2008
Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress.
    The Journal of biological chemistry, 2008, Jun-20, Volume: 283, Issue:25

    Topics: Acetylcysteine; Aldehydes; Animals; Biomarkers; Carbon Tetrachloride; Chromatography, Liquid; Lactones; Linoleic Acid; Lipid Peroxidation; Mass Spectrometry; Models, Chemical; Oxidative Stress; Rats; Rats, Inbred F344

2008
Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic beta-cells.
    American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:2

    Topics: Acetylcysteine; Aldehydes; Amino Acid Transport System y+; Animals; Animals, Newborn; Biological Transport; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine; Fibroblasts; Gene Expression; Glutathione; Homeodomain Proteins; Humans; Hydrogen Peroxide; Insulin-Secreting Cells; Kinetics; Oxidative Stress; Protein Transport; Rats; Rats, Wistar; Trans-Activators

2008
Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE.
    Chemical research in toxicology, 2008, Volume: 21, Issue:7

    Topics: Acetylcysteine; Aldehydes; Cross-Linking Reagents; Histidine; Lipoproteins, LDL; Lysine; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2008
Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:1

    Topics: Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Biological Transport; Carnosine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Male; Mechanics; Nonlinear Dynamics; Oxidative Stress; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Regression Analysis; Sulfhydryl Compounds; Synaptosomes; Transport Vesicles; Tritium

2009
Comparative effects of N-acetyl-L-cysteine and ramipril on arterial hypertension, insulin resistance, and oxidative stress in chronically glucose-fed rats.
    Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:11

    Topics: Acetylcysteine; Aldehydes; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Diet; Free Radical Scavengers; Glucose; Hypertension; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Peroxidation; Liver; Male; Malondialdehyde; Muscle, Skeletal; NADPH Oxidases; Oxidative Stress; Oxygen Consumption; Ramipril; Rats; Rats, Wistar

2008
Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression.
    Circulation research, 2009, Feb-13, Volume: 104, Issue:3

    Topics: Acetylcysteine; Aldehydes; Apoptosis; Atherosclerosis; Biomarkers; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endothelial Cells; Enzyme Inhibitors; Free Radical Scavengers; HSP70 Heat-Shock Proteins; Humans; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Ketocholesterols; Lipoproteins, LDL; Oxygen; Proteins; Stress, Physiological

2009
Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization.
    Chemico-biological interactions, 2009, Nov-10, Volume: 182, Issue:1

    Topics: Acetylcysteine; Aldehydes; Animals; Cell Line; Chemokine CCL5; Chemokine CXCL10; Dimerization; Dithiothreitol; Humans; Immunoblotting; Inflammation; Interferon-beta; Lipopolysaccharides; Mice; Phagocytosis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2009
N-acetylcysteine is able to reduce the oxidation status and the endothelial activation after a high-glucose content meal in patients with Type 2 diabetes mellitus.
    Journal of endocrinological investigation, 2009, Volume: 32, Issue:4

    Topics: Acetylcysteine; Aged; Aldehydes; Case-Control Studies; Diabetes Mellitus, Type 2; E-Selectin; Endothelium, Vascular; Female; Free Radical Scavengers; Glucose; Glycemic Index; Humans; Insulin; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxidative Stress; Postprandial Period; Vascular Cell Adhesion Molecule-1

2009
Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study.
    Free radical biology & medicine, 2010, Jan-01, Volume: 48, Issue:1

    Topics: Acetylcysteine; Adolescent; Adult; Aged; Aldehydes; Female; Humans; Male; Middle Aged; Oxidative Stress; Reference Values; Smoking Cessation; Young Adult

2010
N-acetylcysteine prevents 4-hydroxynonenal- and amyloid-beta-induced modification and inactivation of neprilysin in SH-SY5Y cells.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 19, Issue:1

    Topics: Acetylcysteine; Aging; Aldehydes; Amyloid beta-Peptides; Antioxidants; Cell Line, Tumor; Enzyme Activation; Humans; Neprilysin; Neuroprotective Agents; Peptide Fragments; Protease Inhibitors

2010
Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.
    Radiology, 2010, Volume: 255, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Aldehydes; Animals; Apoptosis; Caspase 3; Catheter Ablation; Combined Modality Therapy; Deoxyguanosine; DNA Damage; Doxorubicin; Female; Histones; HSP70 Heat-Shock Proteins; Immunoenzyme Techniques; Mammary Neoplasms, Experimental; Oxidative Stress; Rats; Rats, Inbred F344; Tyrosine

2010
Science to practice: will randomized prospective clinical trials be necessary for RF ablation of large liver tumors with liposomal doxorubicin?
    Radiology, 2010, Volume: 255, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Adenocarcinoma; Aldehydes; Animals; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Catheter Ablation; Chemotherapy, Adjuvant; Combined Modality Therapy; Deoxyguanosine; DNA Damage; Doxorubicin; Histones; HSP70 Heat-Shock Proteins; Humans; Liver Neoplasms; Mammary Neoplasms, Experimental; Oxidative Stress; Prospective Studies; Randomized Controlled Trials as Topic; Rats; Tyrosine

2010
Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells.
    American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:3

    Topics: Acetylcysteine; Aldehydes; Antioxidants; Cystine; Glucose; Glutathione; Humans; Intracellular Space; Myocytes, Smooth Muscle; Oxidative Stress; Selenomethionine; Spermine

2010
Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes.
    Archives of biochemistry and biophysics, 2010, Nov-15, Volume: 503, Issue:2

    Topics: Acetylcysteine; Aldehydes; Animals; Dipeptides; Fatty Acids, Unsaturated; Glutathione; Hepatocytes; Humans; Hydroxy Acids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Rabbits; Rats

2010
Suppression of choroidal neovascularization by N-acetyl-cysteine in mice.
    Current eye research, 2010, Volume: 35, Issue:11

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Blotting, Western; Chemokine CCL2; Chemokine CXCL1; Choroidal Neovascularization; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Injections, Intraperitoneal; Macrophages; Male; Mice; Mice, Inbred C57BL; Neutrophils; NF-kappa B; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2

2010
The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy.
    Diabetologia, 2011, Volume: 54, Issue:2

    Topics: Acetylcysteine; Aldehydes; Animals; beta Catenin; Blotting, Western; Cell Line; Connective Tissue Growth Factor; Diabetic Retinopathy; Female; Humans; Hydrogen Peroxide; Immunohistochemistry; Ketocholesterols; LDL-Receptor Related Proteins; Lipid Peroxidation; Low Density Lipoprotein Receptor-Related Protein-6; Oxidative Stress; Rats; TCF Transcription Factors

2011
Effects of 4-hydroxy-2-nonenal, a major lipid peroxidation-derived aldehyde, and N-acetylcysteine on the cyclooxygenase-2 expression in human uterine myometrium.
    Gynecologic and obstetric investigation, 2011, Volume: 72, Issue:1

    Topics: Acetylcysteine; Aldehydes; Cyclooxygenase 2; Dinoprostone; Epoprostenol; Female; Gene Expression; Humans; Myometrium; Obstetric Labor, Premature; Pregnancy; RNA, Messenger; Tissue Culture Techniques

2011
The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.
    Molecular carcinogenesis, 2011, Volume: 50, Issue:10

    Topics: Acetylcysteine; Aged; Aldehydes; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cell Line, Tumor; ErbB Receptors; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione Transferase; Humans; Immunohistochemistry; Male; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tyrphostins

2011
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.
    Toxicology and applied pharmacology, 2012, Sep-15, Volume: 263, Issue:3

    Topics: Acetylation; Acetylcysteine; Acrolein; Aldehydes; Alzheimer Disease; Amidohydrolases; Aminooxyacetic Acid; Animals; Cerebral Cortex; Enzyme Inhibitors; Male; Neurons; Parkinson Disease; Rats; Rats, Wistar

2012
Stobadine attenuates impairment of an intestinal barrier model caused by 4-hydroxynonenal.
    Toxicology in vitro : an international journal published in association with BIBRA, 2013, Volume: 27, Issue:1

    Topics: Acetylcysteine; Aldehydes; Antioxidants; Caco-2 Cells; Carbolines; Cell Differentiation; Cell Survival; Chromans; Humans; Intestinal Mucosa; Lipid Peroxidation; Permeability; Reactive Oxygen Species

2013
Inhibition of NF-κB activation by 4-hydroxynonenal contributes to liver injury in a mouse model of alcoholic liver disease.
    The American journal of pathology, 2012, Volume: 181, Issue:5

    Topics: Acetylcysteine; Aldehydes; Animals; Bezafibrate; Caspases; Cell Death; Cytoprotection; Disease Models, Animal; Enzyme Activation; Ethanol; Hep G2 Cells; Hepatocytes; Humans; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Time Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha

2012
Exercise ameliorates cognition impairment due to restraint stress-induced oxidative insult and reduced BDNF level.
    Biochemical and biophysical research communications, 2013, May-03, Volume: 434, Issue:2

    Topics: Acetylcysteine; Aldehydes; Animals; Brain-Derived Neurotrophic Factor; Cognition; Cognition Disorders; Corticosterone; Dose-Response Relationship, Drug; Exercise Test; Hippocampus; Hydrogen Peroxide; Immunohistochemistry; Male; Malondialdehyde; Maze Learning; Mice; Mice, Inbred C57BL; Oxidative Stress; Phosphorylation; Physical Conditioning, Animal; Primary Cell Culture; Reactive Oxygen Species; Restraint, Physical; Signal Transduction; Stress, Psychological

2013
4-Hydroxy-2-nonenal enhances tissue factor activity in human monocytic cells via p38 mitogen-activated protein kinase activation-dependent phosphatidylserine exposure.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:7

    Topics: Acetylcysteine; Aldehydes; Antioxidants; Blood Coagulation; Cell Line, Tumor; Cell-Derived Microparticles; Cytokines; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Factor Xa; Fibroblasts; Humans; Lipid Peroxidation; Lipopolysaccharides; Monocytes; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphatidylserines; Reactive Oxygen Species; Signal Transduction; Thrombin; Thromboplastin; Time Factors

2013
Apoptotic cell death in cultured cardiomyocytes following exposure to low concentrations of 4-hydroxy-2-nonenal.
    Cardiovascular toxicology, 2014, Volume: 14, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Animals, Newborn; Antioxidants; Apoptosis; Calcium; Cardiotoxicity; Cells, Cultured; Chromans; Cysteine Proteinase Inhibitors; Cytoskeleton; Flow Cytometry; Lipid Peroxidation; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Wistar

2014
3-Methyl-1-phenyl-2-pyrazolin-5-one or N-acetylcysteine prevents hippocampal mossy fiber sprouting and rectifies subsequent convulsive susceptibility in a rat model of kainic acid-induced seizure ceased by pentobarbital.
    Brain research, 2014, Nov-24, Volume: 1590

    Topics: Acetylcysteine; Aldehydes; Animals; Anticonvulsants; Antipyrine; Cell Survival; Edaravone; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Glutathione; Kainic Acid; Male; Mossy Fibers, Hippocampal; Pentobarbital; Rats; Rats, Sprague-Dawley; Seizures

2014
Effect of N-acetylcysteine plus deferoxamine on oxidative stress and inflammation in dystrophic muscle cells.
    Redox report : communications in free radical research, 2015, Volume: 20, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Cells, Cultured; Deferoxamine; Hydrogen Peroxide; Inflammation; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; NF-kappa B; Oxidative Stress; Tumor Necrosis Factor-alpha

2015
"Twin peaks": searching for 4-hydroxynonenal urinary metabolites after oral administration in rats.
    Redox biology, 2015, Volume: 4

    Topics: Acetylcysteine; Administration, Oral; Aldehydes; Animals; Chromatography, High Pressure Liquid; Dietary Fats, Unsaturated; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Glutathione; Hydroxy Acids; Lipid Peroxidation; Liver; Oxidation-Reduction; Rats

2015
Autophagy attenuates noise-induced hearing loss by reducing oxidative stress.
    Antioxidants & redox signaling, 2015, May-20, Volume: 22, Issue:15

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Autophagy; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Male; Mice; Microtubule-Associated Proteins; Oxidative Stress; Sirolimus; Tyrosine

2015
The effects of n-acetylcysteine and/or deferoxamine on manic-like behavior and brain oxidative damage in mice submitted to the paradoxal sleep deprivation model of mania.
    Journal of psychiatric research, 2015, Volume: 65

    Topics: Acetylcysteine; Aldehydes; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Deferoxamine; Disease Models, Animal; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Sleep Deprivation; Tyrosine

2015
The oxidant role of 4-hydroxynonenal in corneal epithelium.
    Scientific reports, 2015, May-29, Volume: 5

    Topics: Acetylcysteine; Aldehydes; Animals; Cells, Cultured; Drug Antagonism; Epithelial Cells; Epithelium, Corneal; Humans; Male; NADPH Oxidase 4; NADPH Oxidases; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Rats; Reactive Oxygen Species

2015
N-acetylcysteine Plus Deferoxamine Improves Cardiac Function in Wistar Rats After Non-reperfused Acute Myocardial Infarction.
    Journal of cardiovascular translational research, 2015, Volume: 8, Issue:5

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Deferoxamine; Echocardiography; Immunohistochemistry; Iron; Iron Chelating Agents; Male; Myocardial Infarction; Myocardium; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Stroke Volume; Sulfhydryl Compounds; Troponin I; Ventricular Function

2015
Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
    Neurobiology of disease, 2015, Volume: 84

    Topics: Acetylcysteine; Aldehydes; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Brain; Disulfides; Lipid Peroxidation; Membrane Glycoproteins; Mice; Oxidative Stress; Peptide Fragments; Presenilin-1; Pyridines

2015
Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.
    Free radical biology & medicine, 2016, Volume: 99

    Topics: Acetylcysteine; Adenosine Triphosphate; Aldehydes; Animals; Apoptosis; Buthionine Sulfoximine; Catalase; CCAAT-Enhancer-Binding Protein-delta; DNA; DNA Breaks, Double-Stranded; Dose-Response Relationship, Radiation; Embryo, Mammalian; Fibroblasts; Gamma Rays; Gene Expression Regulation; Glutathione; Mice; Mice, Knockout; Mitochondria; Oxidative Stress; Polyethylene Glycols; Primary Cell Culture; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase

2016
4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells.
    Scientific reports, 2016, 09-13, Volume: 6

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Apoptosis; Caspase 3; Cell Line; Dual Specificity Phosphatase 1; Glutathione; Intestinal Mucosa; MAP Kinase Signaling System; Rats; Reactive Oxygen Species; Swine

2016
α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties.
    Toxicology, 2017, 07-01, Volume: 386

    Topics: Acetylcysteine; Aldehydes; Antioxidants; Apoptosis; Caspase 3; Caspase 9; Cell Line; Cytochromes c; DNA Fragmentation; Glutathione; Glutathione Reductase; Humans; Ketones; Membrane Potential, Mitochondrial; Neurons; Polyethylene Glycols; Pyrrolidines; Reactive Oxygen Species

2017
Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes.
    The journal of investigative dermatology. Symposium proceedings, 2017, Volume: 18, Issue:2

    Topics: Acetylcysteine; Aldehydes; Alopecia; Androstenedione; Cells, Cultured; Free Radical Scavengers; Humans; Keratinocytes; Prostaglandin D2; Reactive Oxygen Species; Signal Transduction; Testosterone

2017
l-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro.
    Acta oto-laryngologica, 2018, Volume: 138, Issue:8

    Topics: Acetylcysteine; Aldehydes; Animals; Drug Evaluation, Preclinical; Free Radical Scavengers; Glutathione; Glutathione Synthase; Hair Cells, Auditory, Outer; Hearing Loss; In Vitro Techniques; Membrane Potential, Mitochondrial; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2018
    International journal of biological sciences, 2023, Volume: 19, Issue:13

    Topics: Acetylcysteine; Aldehydes; Animals; Arthritis, Rheumatoid; Humans; Leukocytes, Mononuclear; Rats

2023