acetyl-dl-leucine has been researched along with leucine in 51 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (5.88) | 18.7374 |
1990's | 6 (11.76) | 18.2507 |
2000's | 9 (17.65) | 29.6817 |
2010's | 21 (41.18) | 24.3611 |
2020's | 12 (23.53) | 2.80 |
Authors | Studies |
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Opella, SJ; Ramamoorthy, A; Wu, CH | 2 |
Benkovic, PA; Benkovic, SJ; Hirschmann, R; Smith, AB; Sprengeler, PA; Taylor, CM; Taylor, SD; Yager, KM | 1 |
Suzuki, T; Ueda, T; Watanabe, K | 1 |
Glaeser, RM; Head-Gordon, T; Pertsemlidis, A; Saxena, AM; Soper, AK | 1 |
Sun, J | 1 |
Vibert, N; Vidal, PP | 1 |
Nevzorov, AA; Opella, SJ | 1 |
DUCROT, R; LEAU, O | 1 |
CELICE, J; DUCHESNAY, G; DUCROT, R; LEAU, O | 1 |
CHINELLATO, F | 1 |
Barta, A; Dorner, S; Schmid, W | 1 |
Jones, DH; Opella, SJ | 1 |
Qiang, W; Weliky, DP; Zheng, Z | 1 |
Opella, SJ; Wu, CH | 1 |
Bourg, M; Clément, G; Deguine, O; Pavy-LeTraon, A | 1 |
Dubreuil, C; Ferber-Viart, C; Vidal, PP | 1 |
Gopinath, T; Veglia, G | 1 |
Gopinath, T; Mote, K; Traaseth, NJ; Veglia, G | 1 |
Gopinath, T; Traaseth, NJ; Veglia, G | 1 |
Nevzorov, AA | 1 |
Feil, K; Feuerecker, R; Habs, M; Klopstock, T; Muth, C; Strupp, M; Teufel, J; van de Warrenburg, BP | 1 |
Beno, DW; Edens, NK; Lee, AJ; Mason, M; Mason-Bright, T; Shapiro, R; Surber, B; Zhang, X | 1 |
Bartenstein, P; Beck, R; Brandt, T; Dieterich, M; Dutia, M; Günther, L; Jahn, K; la Fougère, C; Potschka, H; Strupp, M; Xiong, G; Zwergal, A | 1 |
Li, Q; Li, Z; Zhang, L | 1 |
Amraoui, Y; Bremova, T; Kolníková, M; Malinová, V; Mengel, E; Reinke, J; Strupp, M | 1 |
Bremova, T; Feil, K; Muth, C; Schniepp, R; Strupp, M; Teufel, J | 1 |
Bernard-Demanze, L; Lacour, M; Leonard, J; Tighilet, B | 1 |
Feil, K; Kalla, R; Muth, C; Strupp, M; Teufel, J | 1 |
Platt, F; Strupp, M | 1 |
Benmekhbi, L; Hurvois, JP; Louafi, F; Roisnel, T | 1 |
Koroloff, SN; Nevzorov, AA | 1 |
Adrion, C; Bayer, O; Berger, I; Bösch, S; Claassen, J; Feil, K; Giordano, I; Hengel, H; Jacobi, H; Klockgether, T; Klopstock, T; Mansmann, U; Müller, HH; Nachbauer, W; Naumann, I; Schöls, L; Stendel, C; Strupp, M; Teufel, J; Uslar, E; van de Warrenburg, B | 1 |
Brenna, G; Pareyson, D; Sagnelli, A; Salsano, E; Scigliuolo, GM | 1 |
Fadıloğlu, S; Göğüş, F; Keskin Çavdar, H; Koçak Yanık, D | 1 |
Amraoui, Y; Bremova-Ertl, T; Cortina-Borja, M; Fineran, P; I Dali, C; Imrie, J; Jones, SA; Kirkegaard, T; Lachmann, R; Mengel, E; Platt, FM; Runz, H; Strupp, M; Te Vruchte, D | 1 |
Kalla, R; Strupp, M | 1 |
Bayer, O; Feil, K; Straube, A; Strupp, M | 1 |
Blanchard, C; Boussageon, R; Jaafari, N; Naudet, F; Perault-Pochat, MC; Pouchain, D; Vaillant Roussel, H; Vanderkam, P | 1 |
Churchill, GC; Galione, A; Platt, FM; Strupp, M | 1 |
Bremova-Ertl, T; Platt, F; Strupp, M | 1 |
Hegdekar, N; Lipinski, MM; Sarkar, C | 1 |
Fields, T; Oertel, W; Schoser, B; Strupp, M | 1 |
Bremova-Ertl, T; Churchill, GC; Factor, C; Factor, M; Galione, A; Patterson, MC; Platt, FM; Strupp, M | 1 |
Bremova-Ertl, T; Claassen, J; Foltan, T; Gascon-Bayarri, J; Gissen, P; Hahn, A; Hassan, A; Hennig, A; Jones, SA; Kolnikova, M; Martakis, K; Raethjen, J; Ramaswami, U; Schneider, SA; Sharma, R | 1 |
Adrion, C; Boesch, S; Doss, S; Feil, K; Giordano, I; Hengel, H; Jacobi, H; Klockgether, T; Klopstock, T; Mansmann, U; Nachbauer, W; Naumann, I; Schöls, L; Steiner, KM; Stendel, C; Strupp, M; Timmann, D | 1 |
Jin, W; Li, W; Li, XL; Min, JZ; Qi, C; Zhao, LL | 1 |
Beyraghi-Tousi, M; Gumpricht, E; Mirzadeh, M; Saberi-Karimian, M; Sahebkar, A | 1 |
Kolb, SA | 1 |
Jin, T; Li, J; Shi, Q; Takashi, M; Todoroki, K; Toyo'oka, T; Zhe Min, J; Zhou, X | 1 |
Billington, I; Churchill, GC; Evans, W; Factor, M; Fields, C; Fields, T; Galione, A; Kay, R; M Bremova, T; Martakis, K; Mathieson, T; Patterson, M; Platt, F; Strupp, M | 1 |
4 review(s) available for acetyl-dl-leucine and leucine
Article | Year |
---|---|
Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus.
Topics: 4-Aminopyridine; Cerebellar Ataxia; Chlorzoxazone; Drug Therapy; Humans; Leucine; Muscle Relaxants, Central; Nystagmus, Pathologic; Potassium Channel Blockers | 2016 |
Update on the pharmacotherapy of cerebellar and central vestibular disorders.
Topics: 4-Aminopyridine; Cerebellar Diseases; Humans; Leucine; Male; Nystagmus, Pathologic; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Vestibular Diseases | 2016 |
Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders.
Topics: Aminopyridines; Animals; Cerebellar Ataxia; Cerebellar Diseases; Humans; Leucine | 2019 |
Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials.
Topics: Dizziness; Humans; Leucine; Randomized Controlled Trials as Topic; Vertigo | 2019 |
6 trial(s) available for acetyl-dl-leucine and leucine
Article | Year |
---|---|
Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy.
Topics: Adult; Aged; Combined Modality Therapy; Ear, Inner; Female; Humans; Leucine; Male; Meniere Disease; Middle Aged; Neuroma, Acoustic; Postural Balance; Treatment Outcome; Vertigo; Vestibular Function Tests; Vestibular Nerve; Vomiting | 2009 |
Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial.
Topics: Adult; Cerebellar Ataxia; Cross-Over Studies; Double-Blind Method; Humans; Leucine; Psychiatric Status Rating Scales; Quality of Life; Spinocerebellar Ataxias | 2017 |
Lack of benefit of acetyl-dl-leucine in patients with multiple system atrophy of the cerebellar type.
Topics: Adult; Female; Humans; Leucine; Male; Middle Aged; Multiple System Atrophy; Treatment Failure; Young Adult | 2017 |
Efficacy and safety of N-acetyl-L-leucine in Niemann-Pick disease type C.
Topics: Adolescent; Adult; Child; Double-Blind Method; Humans; Leucine; Middle Aged; Niemann-Pick Disease, Type C; Quality of Life; Treatment Outcome; Young Adult | 2022 |
Safety and Efficacy of Acetyl-DL-Leucine in Certain Types of Cerebellar Ataxia: The ALCAT Randomized Clinical Crossover Trial.
Topics: Administration, Oral; Adult; Aged; Cerebellar Ataxia; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Humans; Leucine; Male; Middle Aged; Treatment Outcome | 2021 |
N-acetyl-L-leucine for Niemann-Pick type C: a multinational double-blind randomized placebo-controlled crossover study.
Topics: Cross-Over Studies; Double-Blind Method; Humans; Leucine; Niemann-Pick Disease, Type C; Quality of Life | 2023 |
41 other study(ies) available for acetyl-dl-leucine and leucine
Article | Year |
---|---|
Three-dimensional solid-state NMR experiment that correlates the chemical shift and dipolar coupling frequencies of two heteronuclei.
Topics: Leucine; Magnetic Resonance Spectroscopy; Nitrogen Isotopes | 1995 |
Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids.
Topics: Antibodies, Catalytic; Antibodies, Monoclonal; Binding Sites, Antibody; Dipeptides; Esters; Haptens; Kinetics; Leucine; Molecular Conformation; Phenylalanine; Stereoisomerism; Tryptophan; Valine | 1994 |
A new method for identifying the amino acid attached to a particular RNA in the cell.
Topics: Acetic Anhydrides; Acetylation; Amino Acids; Base Sequence; Candida; Carbon Radioisotopes; Chromatography, Thin Layer; DNA Probes; Indicators and Reagents; Kinetics; Leucine; Molecular Sequence Data; Oligonucleotide Probes; RNA, Fungal; RNA, Transfer, Amino Acyl; Serine | 1996 |
Direct evidence for modified solvent structure within the hydration shell of a hydrophobic amino acid.
Topics: Amides; Amino Acids; Glutamine; Leucine; Lysine; Neutrons; Scattering, Radiation; Solubility; Solvents; Water | 1996 |
[Effects of acetyl-DL-leucine on the recovery of the locomotor equilibrium and spontaneous discharge of lateral vestibular nucleus neurons in unilateral vestibular neurectomized cats].
Topics: Animals; Anti-Dyskinesia Agents; Cats; Electrophysiology; Leucine; Motor Activity; Neurons; Postural Balance; Rhombencephalon; Sensation Disorders; Vestibular Nerve | 1997 |
Experimental aspects of multidimensional solid-state NMR correlation spectroscopy.
Topics: Hydrogen Bonding; Leucine; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular | 1999 |
In vitro effects of acetyl-DL-leucine (tanganil) on central vestibular neurons and vestibulo-ocular networks of the guinea-pig.
Topics: Abducens Nerve; Animals; Brain; Drug Resistance; Ear, Inner; Evoked Potentials; Female; Guinea Pigs; Leucine; Male; Membrane Potentials; Neurons; Neurons, Afferent; Vertigo; Vestibular Nerve; Vestibular Nuclei | 2001 |
A "magic sandwich" pulse sequence with reduced offset dependence for high-resolution separated local field spectroscopy.
Topics: Computer Simulation; Crystallography; Leucine; Magnetics; Models, Molecular; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Protons; Quality Control; Signal Processing, Computer-Assisted; Spin Labels | 2003 |
[Action of acetylleucine on experimental vertigo in mice].
Topics: Animals; Leucine; Mice; Vertigo | 1957 |
[Trial therapy of labyrinthine vertigo by acetyl-DL-leucine].
Topics: Humans; Leucine; Meniere Disease; Vertigo | 1958 |
[Experimental research on the behavior of vestibular function after the administration of certain drugs. II. Acetyl-DL-leucine].
Topics: Ear, Inner; Leucine; Pharmaceutical Preparations; Vestibule, Labyrinth | 1960 |
Activity of 3'-thioAMP derivatives as ribosomal P-site substrates.
Topics: Adenosine Monophosphate; Leucine; Manganese; Models, Chemical; Protein Biosynthesis; Ribosomes; RNA, Transfer, Phe; Thionucleotides | 2005 |
Application of Maximum Entropy reconstruction to PISEMA spectra.
Topics: Bacteriophages; Image Enhancement; Leucine; Lipid Bilayers; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Signal Processing, Computer-Assisted | 2006 |
Investigation of finite-pulse radiofrequency-driven recoupling methods for measurement of intercarbonyl distances in polycrystalline and membrane-associated HIV fusion peptide samples.
Topics: Amino Acid Sequence; Crystallization; HIV; Leucine; Magnetic Resonance Spectroscopy; Membrane Fusion; Membrane Lipids; Molecular Sequence Data; Protein Structure, Secondary; Radio Waves; Signal-To-Noise Ratio; Viral Fusion Proteins | 2007 |
Shiftless nuclear magnetic resonance spectroscopy.
Topics: Carbon Isotopes; Leucine; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular | 2008 |
Effects of vestibular training on motion sickness, nystagmus, and subjective vertical.
Topics: Adult; Habituation, Psychophysiologic; Humans; Leucine; Male; Motion Sickness; Nystagmus, Physiologic; Posture; Rotation; Vestibule, Labyrinth | 2007 |
Sensitivity enhancement in static solid-state NMR experiments via single- and multiple-quantum dipolar coherences.
Topics: Crystallization; Leucine; Nuclear Magnetic Resonance, Biomolecular; Sensitivity and Specificity | 2009 |
Sensitivity enhanced heteronuclear correlation spectroscopy in multidimensional solid-state NMR of oriented systems via chemical shift coherences.
Topics: Leucine; Lipid Bilayers; Models, Chemical; Muscle Proteins; Nuclear Magnetic Resonance, Biomolecular; Proteolipids | 2010 |
On the performance of spin diffusion NMR techniques in oriented solids: prospects for resonance assignments and distance measurements from separated local field experiments.
Topics: Diffusion; Dipeptides; Leucine; Magnetic Resonance Spectroscopy; Protons | 2010 |
Ergodicity and efficiency of cross-polarization in NMR of static solids.
Topics: Algorithms; Computer Simulation; Diffusion; Electromagnetic Fields; Electron Spin Resonance Spectroscopy; Leucine; Magnetic Resonance Spectroscopy; Membrane Proteins | 2011 |
Effects of acetyl-DL-leucine in patients with cerebellar ataxia: a case series.
Topics: Adolescent; Adult; Aged; Cerebellar Ataxia; Disability Evaluation; Female; Humans; Leucine; Male; Middle Aged; Quality of Life; Severity of Illness Index; Treatment Outcome; Young Adult | 2013 |
A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dipeptides; Intestinal Absorption; Keto Acids; Leucine; Male; Mass Spectrometry; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Valerates | 2015 |
N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
Topics: Animals; Cerebellum; Leucine; Male; Nystagmus, Pathologic; Postural Balance; Rats, Sprague-Dawley; Sensation Disorders; Thalamus; Vestibule, Labyrinth | 2015 |
Induction of apoptosis in cancer cells through N-acetyl-l-leucine-modified polyethylenimine-mediated p53 gene delivery.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Gene Transfer Techniques; Genes, p53; HeLa Cells; Humans; Leucine; Membrane Potential, Mitochondrial; Polyethyleneimine; Transfection | 2015 |
Acetyl-dl-leucine in Niemann-Pick type C: A case series.
Topics: Adolescent; Adult; Female; Humans; Leucine; Male; Niemann-Pick Disease, Type C; Quality of Life; Young Adult | 2015 |
Comparative analysis of pharmacological treatments with N-acetyl-DL-leucine (Tanganil) and its two isomers (N-acetyl-L-leucine and N-acetyl-D-leucine) on vestibular compensation: Behavioral investigation in the cat.
Topics: Animals; Behavior, Animal; Cats; Isomerism; Leucine; Motor Activity; Nystagmus, Pathologic; Postural Balance; Vestibule, Labyrinth | 2015 |
An anecdotal report by an Oxford basic neuroscientist: effects of acetyl-DL-leucine on cognitive function and mobility in the elderly.
Topics: Aged, 80 and over; Central Nervous System Agents; Cognition; Gait Disorders, Neurologic; Humans; Leucine; Male; Motor Activity; Nootropic Agents; Quality of Life | 2016 |
Synthesis of Tetrahydroisoquinoline Alkaloids and Related Compounds through the Alkylation of Anodically Prepared α-Amino Nitriles.
Topics: Alkaloids; Alkylation; Carbon; Catalysis; Crystallography, X-Ray; Electrodes; Isoquinolines; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Nitriles; Oxidation-Reduction; Salsoline Alkaloids; Solvents; Stereoisomerism; Tetrahydroisoquinolines | 2016 |
Selective excitation for spectral editing and assignment in separated local field experiments of oriented membrane proteins.
Topics: Algorithms; Amino Acids; Isotope Labeling; Leucine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Proteins; Micelles; Nitrogen Isotopes; Normal Distribution; Nuclear Magnetic Resonance, Biomolecular; Spin Labels | 2017 |
A Novel Modified Lipid: Enzymatic Esterification of 2-Monoacylglycerol with N-acetyl-l-leucine.
Topics: Esterification; Leucine; Lipase; Mass Spectrometry; Molecular Structure; Monoglycerides; Oleic Acid; Olive Oil | 2018 |
Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials.
Topics: Adult; Clinical Trials as Topic; Cohort Studies; Female; Humans; Leucine; Lysosomal Storage Diseases; Male; Niemann-Pick Disease, Type C; Surveys and Questionnaires; Young Adult | 2018 |
Prophylactic treatment of migraine with and without aura with acetyl-DL-leucine: a case series.
Topics: Adolescent; Adult; Aged; Female; Humans; Leucine; Male; Middle Aged; Migraine with Aura; Migraine without Aura; Treatment Outcome; Young Adult | 2019 |
Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Transport, Active; Chromatography, High Pressure Liquid; Humans; Leucine; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Models, Biological; Stereoisomerism | 2020 |
Sandhoff Disease: Improvement of Gait by Acetyl-DL-Leucine: A Case Report.
Topics: Child; Gait; Humans; Leucine; Male; Sandhoff Disease; Treatment Outcome | 2020 |
N-Acetyl-L-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice.
Topics: Animals; Autophagy; Brain Injuries, Traumatic; Cell Death; Cerebral Cortex; Disease Models, Animal; Hippocampus; Inflammation; Leucine; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Recovery of Function | 2021 |
Acetyl-DL-leucine improves restless legs syndrome: a case report.
Topics: Humans; Leucine; Restless Legs Syndrome | 2021 |
Acetylation turns leucine into a drug by membrane transporter switching.
Topics: Acetylation; Biological Transport; HEK293 Cells; Humans; Kinetics; Large Neutral Amino Acid-Transporter 1; Leucine; Monocarboxylic Acid Transporters; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Prodrugs; Signal Transduction; Symporters | 2021 |
Determination of N-acetyl-DL-leucine in the saliva of healthy volunteers and diabetic patients using ultra-performance liquid chromatography with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Diabetes Mellitus, Type 2; Healthy Volunteers; Humans; Leucine; Saliva; Stereoisomerism | 2022 |
The Effect of N-Acetyl-DL-Leucine on Neurological Symptoms in a Patient with Ataxia-Telangiectasia: a Case Study.
Topics: Ataxia Telangiectasia; Cerebellar Ataxia; Child; Female; Humans; Leucine; Quality of Life | 2023 |
Beneficial effect of N-acetyl-DL-leucine on cognitive function, emotional well-being and QoL in a mentally healthy elderly person.
Topics: Aged; Cognition; Emotions; Health Status; Humans; Leucine; Quality of Life | 2023 |
Development of a novel method for analysing N-acetyl-DL-leucine enantiomers in human fingernail by UPLC-ESI-MS/MS and the evaluation in diabetes mellitus.
Topics: Chromatography, High Pressure Liquid; Diabetes Mellitus; Humans; Leucine; Nails; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tandem Mass Spectrometry | 2023 |