acetyl coenzyme a has been researched along with dichloroacetic acid in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| DeBuysere, MS; Dennis, SC; Olson, MS; Padmas, A | 1 |
| Cederblad, G; Constantin-Teodosiu, D; Hultman, E | 1 |
| Agius, L; Vaartjes, WJ | 1 |
| Hu, CW; Sheu, KF; Utter, MF | 1 |
| Buc, HA; Demaugre, F; Leroux, JP; Moncion, A | 1 |
| Bielarczyk, H; Skulimowska, H; Szutowicz, A | 1 |
| Clarke, B; McCormack, JG; Wyatt, KM | 1 |
| Clanachan, AS; Liu, B; Lopaschuk, GD; Schulz, R | 1 |
| Bersin, RM; Stacpoole, PW | 1 |
| Bowker-Kinley, MM; Davis, WI; Harris, RA; Popov, KM; Wu, P | 1 |
| Heigenhauser, GJ; Howlett, RA; Spriet, LL | 1 |
| Baker, JC; Kasten, S; Peng, T; Roche, TE; Yan, X | 1 |
| Heigenhauser, GJ; Hollidge-Horvat, MG; Hultman, E; Jones, NL; Matsos, MP; Parolin, ML; Spriet, LL | 1 |
| Brocks, C; Chatham, JC; Lloyd, S | 1 |
| Bao, H; Kasten, SA; Roche, TE; Yan, X | 1 |
| Bruchelt, G; Deubzer, B; Handgretinger, R; Krampen, L; Kuçi, Z; Niewisch, MR; Sautter, M; Wolburg, H | 1 |
| Hurd, RE; Jang, T; Josan, S; Mayer, D; Merchant, M; Park, JM; Recht, LD; Spielman, DM; Yen, YF | 1 |
| Atsushi, A; Endo, J; Fukuda, K; Hishiki, T; Iso, T; Kaneda, R; Katsumata, Y; Matsuhashi, T; Ono, T; Sano, M; Shinmura, K; Shirakawa, K; Suematsu, M; Yamaguchi, A; Yamamoto, T; Yan, X; Zhou, H | 1 |
| Blomgren, K; Li, T; Sun, Y; Wang, X; Xie, C; Zhang, Y; Zhou, K; Zhu, C | 1 |
| Stacpoole, PW | 1 |
| Hu, X; Tam, KY; Zhang, W; Zhou, W | 1 |
| Abdel-Aziz, W; Abdel-Latif, HM; Aboonq, MS; Ahmed, NS; Almaramhy, HH; Ayat, M; Baghdadi, H; El Sayed, SM; El-Sawy, SA; Elshazley, M; Ibrahim, W; Mahmoud, AA | 1 |
| Hewitson, TD; Smith, ER | 1 |
| Angus, DC; Bakalov, V; Chang, CH; Deshpande, R; Kaynar, AM; Le Moyec, L; Maloy, AL; Reyes-Uribe, L; Shapiro, SD; Wendell, SG | 1 |
1 review(s) available for acetyl coenzyme a and dichloroacetic acid
| Article | Year |
|---|---|
Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Biomimetics; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glycolysis; Humans; Isoenzymes; Mitochondria; NAD; Neoplasms; Oxidative Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid | 2017 |
2 trial(s) available for acetyl coenzyme a and dichloroacetic acid
| Article | Year |
|---|---|
Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion.
Topics: Acetates; Acetyl Coenzyme A; Acetylation; Acetylcarnitine; Adenosine Triphosphate; Adult; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Ergometry; Exercise; Female; Humans; Male; Muscle, Skeletal; Oxidation-Reduction; Oxygen Consumption; Pyruvate Dehydrogenase Complex; Rest; Running | 1999 |
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Blood Glucose; Blood Pressure; Dichloroacetic Acid; Glycogen; Glycolysis; Heart Rate; Humans; Hypoxia; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Phosphocreatine; Phosphorylases; Physical Exertion; Pyruvate Dehydrogenase Complex; Respiratory Function Tests | 2000 |
21 other study(ies) available for acetyl coenzyme a and dichloroacetic acid
| Article | Year |
|---|---|
Studies on the regulation of pyruvate dehydrogenase in the isolated perfused rat heart.
Topics: Acetyl Coenzyme A; Adenine Nucleotides; Animals; Coenzyme A; Dichloroacetic Acid; In Vitro Techniques; Kinetics; Male; Myocardium; NAD; Oxidation-Reduction; Perfusion; Pyruvate Dehydrogenase Complex; Pyruvates; Rats | 1979 |
A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue.
Topics: Acetyl Coenzyme A; Calcium; Carbon Radioisotopes; Dichloroacetic Acid; Enzyme Activation; Glucose; Hexokinase; Humans; Magnesium; Muscles; Pyruvate Dehydrogenase Complex; Substrate Specificity | 1991 |
Effect of insulin on ketogenesis and fatty acid synthesis in rat hepatocytes incubated with dichloroacetate.
Topics: Acetates; Acetyl Coenzyme A; Animals; Carbon Dioxide; Citrates; Citric Acid; Dichloroacetic Acid; Enzyme Activation; Fatty Acids; Female; Insulin; Ketone Bodies; Liver; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
Pyruvate dehydrogenase complex activity in normal and deficient fibroblasts.
Topics: Acetyl Coenzyme A; Carbon Dioxide; Cell-Free System; Cells, Cultured; Dichloroacetic Acid; Enzyme Activation; Fluorides; Humans; Phosphoprotein Phosphatases; Phosphorylation; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Skin | 1981 |
Effects of oxalate and dichloroacetate on lipogenesis and ketogenesis in rat hepatocytes.
Topics: Acetates; Acetyl Coenzyme A; Animals; Dichloroacetic Acid; Female; Ketone Bodies; Lipid Metabolism; Liver; Oxalates; Oxalic Acid; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains | 1982 |
Effect of dichloroacetate on acetyl-CoA content and acetylcholine synthesis in rat brain synaptosomes.
Topics: Acetyl Coenzyme A; Acetylcholine; Animals; Brain; Dichloroacetic Acid; Male; Mitochondria; Nerve Endings; Pyruvates; Rats; Rats, Wistar; Synaptosomes | 1994 |
Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism.
Topics: Acetanilides; Acetyl Coenzyme A; Animals; Coenzyme A; Dichloroacetic Acid; Heart; Male; Myocardium; Perfusion; Piperazines; Pyruvate Dehydrogenase Complex; Ranolazine; Rats; Rats, Wistar; Reference Values | 1996 |
Cardiac efficiency is improved after ischemia by altering both the source and fate of protons.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Amiloride; Animals; Dichloroacetic Acid; Glucose; Glycolysis; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Oxidation-Reduction; Palmitic Acid; Protons; Rats; Rats, Sprague-Dawley; Time Factors; Tricarboxylic Acids | 1996 |
Dichloroacetate as metabolic therapy for myocardial ischemia and failure.
Topics: Acetyl Coenzyme A; Dichloroacetic Acid; Energy Metabolism; Heart; Heart Failure; Humans; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Pyruvate Dehydrogenase Complex | 1997 |
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.
Topics: Acetyl Coenzyme A; Animals; Blotting, Northern; Cloning, Molecular; Dichloroacetic Acid; Gene Expression Regulation, Enzymologic; Isoenzymes; Kinetics; Molecular Sequence Data; NAD; Pyruvate Dehydrogenase Complex; Rats; Recombinant Proteins; RNA, Messenger; Sequence Analysis, DNA | 1998 |
Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
Topics: Acetyl Coenzyme A; Acetylation; Acetyltransferases; Binding Sites; Buffers; Dichloroacetic Acid; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; NAD; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Recombinant Proteins | 2000 |
Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.
Topics: Acetyl Coenzyme A; Alanine; Animals; Buffers; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glucose; Heart; Heart Function Tests; Heart Rate; Hypoglycemic Agents; In Vitro Techniques; Insulin; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardium; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2003 |
Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosine Diphosphate; Adenosine Triphosphate; Binding, Competitive; Catalysis; Dichloroacetic Acid; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Activation; Humans; Isoenzymes; Kinetics; Osmolar Concentration; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein Subunits; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Substrate Specificity | 2004 |
Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?
Topics: Acetyl Coenzyme A; Apoptosis; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Culture Media; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Lactic Acid; Mitochondria; Neuroblastoma; Oxidative Phosphorylation; Oxygen; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Reactive Oxygen Species | 2012 |
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging.
Topics: Acetyl Coenzyme A; Animals; Brain; Brain Neoplasms; Carbon Radioisotopes; Dichloroacetic Acid; Glioma; Magnetic Resonance Imaging; Male; Mitochondria; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvates; Rats; Rats, Wistar; Tumor Cells, Cultured | 2013 |
Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.
Topics: 3-Hydroxybutyric Acid; Acetyl Coenzyme A; Acetylation; Animals; Dichloroacetic Acid; Epigenesis, Genetic; Gene Expression Regulation; Heart; Histones; Male; Metabolome; Metabolomics; Mice; Mitochondria; Myocardium; Organ Specificity; Phosphorylation; Pyruvate Dehydrogenase Complex; Rats; Transcription, Genetic; Ventricular Remodeling | 2015 |
Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice.
Topics: Acetyl Coenzyme A; Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Brain Injuries; Caspases; Cytoprotection; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Hypoxia-Ischemia, Brain; Male; Mice, Inbred C57BL; Mitochondria; Mitochondrial Dynamics; Neuroprotective Agents; Organelle Biogenesis; Pyruvate Dehydrogenase Complex; Time Factors | 2016 |
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors.
Topics: A549 Cells; Acetyl Coenzyme A; Anilides; Antineoplastic Agents; Chromatography, Liquid; Citric Acid Cycle; Cytosol; Dichloroacetic Acid; Gene Expression Regulation; Glucose; Glycolysis; Humans; Isoenzymes; Lactic Acid; Mitochondria; Oxidative Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Tandem Mass Spectrometry | 2018 |
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis.
Topics: Acetates; Acetyl Coenzyme A; Animals; Antineoplastic Agents; Brain Neoplasms; Chlorides; Dichloroacetic Acid; Evidence-Based Medicine; Glioblastoma; Heart; Humans; Ketones; Lactic Acid; Models, Theoretical; Neoplasms; Oxygen; Perfusion; Rats | 2019 |
TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts.
Topics: Acetyl Coenzyme A; Acetylation; Actins; Caprylates; Collagen Type I; Dichloroacetic Acid; Down-Regulation; Fibroblasts; Humans; Kidney; Mutation; Oxidative Phosphorylation; Protein Phosphatase 2C; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Sulfides; Transforming Growth Factor beta1 | 2020 |
Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.
Topics: Acetyl Coenzyme A; Animals; Citric Acid Cycle; Dichloroacetic Acid; Drosophila melanogaster; Glycolysis; Inflammation; Lactic Acid; Longevity; Oxidative Phosphorylation; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Sepsis | 2020 |