Compounds > acetyl-aspartyl-glutamyl-valyl-aspartal

acetyl-aspartyl-glutamyl-valyl-aspartal and rhodamine-110

acetyl-aspartyl-glutamyl-valyl-aspartal has been researched along with rhodamine-110* in 1 studies

Other Studies

1 other study(ies) available for acetyl-aspartyl-glutamyl-valyl-aspartal and rhodamine-110

Article	Year
Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay. Bioorganic & medicinal chemistry letters, 2001, Jan-08, Volume: 11, Issue:1 N-Octyloxycarbonyl-R110 (1), with enhanced cell penetration and retention properties, was prepared from rhodamine 110. The tetrapeptide substrate N-Ac-DEVD-N'-octyloxycarbonyl-R110 (3) was prepared and shown to be efficiently cleaved by human recombinant caspase-3 and by apoptotic HL-60 cells. This substrate should prove useful in cell-based assays for apoptosis inducers and inhibitors. Topics: Apoptosis; Caspase 3; Caspases; Drug Design; Fluorescence; Fluorescent Dyes; HL-60 Cells; Humans; Microscopy, Fluorescence; Molecular Structure; Oligopeptides; Recombinant Proteins; Rhodamines; Substrate Specificity	2001

Article

Year

Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay.

Bioorganic & medicinal chemistry letters, 2001, Jan-08, Volume: 11, Issue:1

N-Octyloxycarbonyl-R110 (1), with enhanced cell penetration and retention properties, was prepared from rhodamine 110. The tetrapeptide substrate N-Ac-DEVD-N'-octyloxycarbonyl-R110 (3) was prepared and shown to be efficiently cleaved by human recombinant caspase-3 and by apoptotic HL-60 cells. This substrate should prove useful in cell-based assays for apoptosis inducers and inhibitors.

Topics: Apoptosis; Caspase 3; Caspases; Drug Design; Fluorescence; Fluorescent Dyes; HL-60 Cells; Humans; Microscopy, Fluorescence; Molecular Structure; Oligopeptides; Recombinant Proteins; Rhodamines; Substrate Specificity

2001