acetone has been researched along with maleylacetone in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anders, MW; Board, PG; Lantum, HB | 2 |
| Anders, MW; Board, PG; Lantum, HB; Liebler, DC | 1 |
| Anders, MW; Baggs, RB; Board, PG; Krenitsky, DM; Lantum, HB | 1 |
| Anders, MW; Blackburn, AC; Board, PG; Dahlstrom, JE; Davis, RP; Koina, ME; Lim, CE; Matthaei, KI | 1 |
| Dixit, V; Guo, X; Henderson, GN; James, MO; Liu, H; Shroads, AL; Stacpoole, PW | 1 |
| Henderson, GN; Jia, M; Liu, H; Stacpoole, PW; Zolodz, MD | 1 |
| Bullock, JR; Coats, BS; Gong, Y; Johnson, JA; Kurtz, TL; Langaee, T; Ostrov, DA; Shroads, AL; Stacpoole, PW; Wagner, DA; Weithorn, D | 1 |
| Abdelmalak, MM; Daigle, AD; James, MO; Maisenbacher, HW; Mincey, BD; Samper, IS; Shroads, AL; Stacpoole, PW; Zhong, G | 1 |
| Coats, BS; Dunbar, EM; Forder, JR; Langaee, T; Lew, A; Shroads, AL; Shuster, JJ; Stacpoole, PW; Wagner, DA | 1 |
| Coats, BS; Langaee, T; McDonough, CW; Shroads, AL; Stacpoole, PW | 1 |
| Coats, BS; Langaee, T; Shroads, AL; Shuster, JJ; Stacpoole, PW | 1 |
3 trial(s) available for acetone and maleylacetone
| Article | Year |
|---|---|
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brain Neoplasms; Breath Tests; Dichloroacetic Acid; Female; Glutathione Transferase; Haplotypes; Humans; Male; Maleates; Middle Aged; Pyruvic Acid | 2014 |
Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
Topics: Acetone; Adolescent; Adult; Aminolevulinic Acid; Child; Child, Preschool; Dichloroacetic Acid; Double-Blind Method; Female; Genetic Diseases, Inborn; Glutathione Transferase; Haplotypes; Humans; Infant; Kinetics; Male; Maleates; Mitochondrial Diseases; Polymorphism, Single Nucleotide; Tyrosine; Young Adult | 2015 |
Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.
Topics: Acetone; Adult; Biomarkers; Chloral Hydrate; cis-trans-Isomerases; Dichloroacetic Acid; Female; Glutathione Transferase; Healthy Volunteers; Humans; Hypnotics and Sedatives; Male; Maleates; Tyrosine; Young Adult | 2015 |
9 other study(ies) available for acetone and maleylacetone
| Article | Year |
|---|---|
Inactivation of polymorphic variants of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.
Topics: Acetates; Acetone; cis-trans-Isomerases; Enzyme Inhibitors; Fumarates; Glyoxylates; Humans; Hydrogen-Ion Concentration; Isoenzymes; Maleates; Polymorphism, Genetic | 2001 |
Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.
Topics: Acetone; Alkylation; Drug Interactions; Enzyme Inhibitors; Fumarates; Glutathione; Glutathione Transferase; Humans; Maleates | 2002 |
Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.
Topics: Acetates; Acetone; Animals; Dichloroacetic Acid; Environmental Pollutants; Glutathione Transferase; Immunoblotting; Immunohistochemistry; Male; Maleates; Organ Specificity; Rats; Rats, Inbred F344; Subcellular Fractions | 2002 |
Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).
Topics: Acetates; Acetone; Biotransformation; cis-trans-Isomerases; Dichloroacetic Acid; Enzyme Inhibitors; Glutathione Transferase; Humans; Hydrogen-Ion Concentration; Kinetics; Maleates; Polymorphism, Single Nucleotide; Recombinant Proteins; Substrate Specificity | 2002 |
Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.
Topics: Acetone; Animals; cis-trans-Isomerases; Diet; Female; Glutathione S-Transferase pi; Glutathione Transferase; Hepatitis; Heptanoates; Isoenzymes; Kidney; Leukocytes; Liver; Male; Maleates; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; NAD(P)H Dehydrogenase (Quinone); Phenylalanine; Spleen; Up-Regulation | 2004 |
Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
Topics: Acetone; Administration, Oral; Aging; Animals; Blotting, Western; Body Weight; Dichloroacetic Acid; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Glutathione Transferase; Humans; Liver; Male; Maleates; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.
Topics: Acetone; Animals; Blotting, Western; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Heptanoates; Humans; Liver; Male; Maleates; Rats; Sensitivity and Specificity; Tyrosine | 2006 |
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Topics: Acetone; Adult; Amino Acid Substitution; Dichloroacetic Acid; Environmental Pollutants; Enzyme Stability; Female; Florida; Genetic Association Studies; Glutathione Transferase; Half-Life; Humans; Male; Maleates; Middle Aged; Models, Molecular; Mutation; Polymorphism, Single Nucleotide; Protein Conformation; Tyrosine; Young Adult | 2012 |
Pharmacokinetics of oral dichloroacetate in dogs.
Topics: Acetone; Analysis of Variance; Animals; Area Under Curve; Blotting, Western; cis-trans-Isomerases; Dichloroacetic Acid; Dogs; Glutathione Transferase; Half-Life; Injections, Intravenous; Male; Maleates; Tyrosine | 2013 |