acetogenins and muricatacin

acetogenins has been researched along with muricatacin* in 3 studies

Reviews

2 review(s) available for acetogenins and muricatacin

Article	Year
Muricatacin, a Gateway Molecule to Higher Acetogenin Synthesis. Chemistry, an Asian journal, 2020, Nov-16, Volume: 15, Issue:22 In this review, we have abstracted the various syntheses of acetogenins where the start point has been muricatacin. The latter can best be synthesized in either enantiomer form by the Sharpless method in three steps and can be admired as a gateway molecule for a quick assembly of many higher acetogenins. Muricatacin with orthogonally differentiated hydroxy groups and the available lactone carbonyl for chain elongation/modification can enable the concise synthesis of higher acetogenins. Many closely related synthetic intermediates possible from muricatacin are also abstracted here. The review should give impetus for future synthetic endeavours where the start point could be muricatacin and at least to the new molecules that are yet to be synthesized. Topics: Acetogenins; Furans; Molecular Structure; Stereoisomerism	2020
Synthesis of annonaceous acetogenins from muricatacin. Bioscience, biotechnology, and biochemistry, 2007, Volume: 71, Issue:10 Synthetic studies of annonaceous acetogenins starting from (-)-muricatacin (1a) or (+)-muricatacin are described, involving (-)-muricatacin (1a), mono-THF acetogenin, solamin (2), reticulatacin (3), (15R, 16R, 19S, 20S)-cis-solamin (4a) and (15S, 16S, 19R, 20R)-cis-solamin (4b), non-adjacent bis-THF acetogenin, 4-deoxygigantecin (5), and epoxide-bearing acetogenin, (15S, 16R, 19S, 20R)-diepomuricanin (6a). Topics: Acetogenins; Antineoplastic Agents, Phytogenic; Benzethonium; Furans; Molecular Structure; Stereoisomerism	2007

Article

Year

Muricatacin, a Gateway Molecule to Higher Acetogenin Synthesis.

Chemistry, an Asian journal, 2020, Nov-16, Volume: 15, Issue:22

In this review, we have abstracted the various syntheses of acetogenins where the start point has been muricatacin. The latter can best be synthesized in either enantiomer form by the Sharpless method in three steps and can be admired as a gateway molecule for a quick assembly of many higher acetogenins. Muricatacin with orthogonally differentiated hydroxy groups and the available lactone carbonyl for chain elongation/modification can enable the concise synthesis of higher acetogenins. Many closely related synthetic intermediates possible from muricatacin are also abstracted here. The review should give impetus for future synthetic endeavours where the start point could be muricatacin and at least to the new molecules that are yet to be synthesized.

Topics: Acetogenins; Furans; Molecular Structure; Stereoisomerism

2020

Synthesis of annonaceous acetogenins from muricatacin.

Bioscience, biotechnology, and biochemistry, 2007, Volume: 71, Issue:10

Synthetic studies of annonaceous acetogenins starting from (-)-muricatacin (1a) or (+)-muricatacin are described, involving (-)-muricatacin (1a), mono-THF acetogenin, solamin (2), reticulatacin (3), (15R, 16R, 19S, 20S)-cis-solamin (4a) and (15S, 16S, 19R, 20R)-cis-solamin (4b), non-adjacent bis-THF acetogenin, 4-deoxygigantecin (5), and epoxide-bearing acetogenin, (15S, 16R, 19S, 20R)-diepomuricanin (6a).

Topics: Acetogenins; Antineoplastic Agents, Phytogenic; Benzethonium; Furans; Molecular Structure; Stereoisomerism

2007

Other Studies

1 other study(ies) available for acetogenins and muricatacin

Article	Year
Total synthesis of (+)-muconin. The Journal of organic chemistry, 2004, Mar-19, Volume: 69, Issue:6 (+)-Muconin (1), isolated from the leaves of Rollinia mucosa (Jacq.) Baill. (Annonaceae), is a sequential THF/THP-possessing acetogenin that exhibits potent and selective in vitro cytotoxicity toward pancreatic and breast tumor cell lines. In this study, a new route was established for obtaining (+)-muconin (1) starting with (-)-muricatacin (2), a compound recently synthesized via the novel alpha-C-H hydroxyalkylation and alpha'-C-H oxidation of tetrahydrofuran. Topics: Acetogenins; Alkylation; Antineoplastic Agents, Phytogenic; Fatty Alcohols; Furans; Lactones; Molecular Structure; Organosilicon Compounds; Oxidation-Reduction; Plant Leaves; Rollinia; Stereoisomerism	2004

Article

Year

Total synthesis of (+)-muconin.

The Journal of organic chemistry, 2004, Mar-19, Volume: 69, Issue:6

(+)-Muconin (1), isolated from the leaves of Rollinia mucosa (Jacq.) Baill. (Annonaceae), is a sequential THF/THP-possessing acetogenin that exhibits potent and selective in vitro cytotoxicity toward pancreatic and breast tumor cell lines. In this study, a new route was established for obtaining (+)-muconin (1) starting with (-)-muricatacin (2), a compound recently synthesized via the novel alpha-C-H hydroxyalkylation and alpha'-C-H oxidation of tetrahydrofuran.

Topics: Acetogenins; Alkylation; Antineoplastic Agents, Phytogenic; Fatty Alcohols; Furans; Lactones; Molecular Structure; Organosilicon Compounds; Oxidation-Reduction; Plant Leaves; Rollinia; Stereoisomerism

2004