acetogenins has been researched along with isomurisolenin* in 1 studies
1 other study(ies) available for acetogenins and isomurisolenin
Article | Year |
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Essential structural features of acetogenins: role of hydroxy groups adjacent to the bis-THF rings.
The presence of two hydroxy groups adjacent to the THF ring(s) is a common structural feature of natural acetogenins. To elucidate the role of each hydroxy group in the inhibitory action of acetogenins, we synthesized three acetogenin analogues which lack either or both of the hydroxy groups, and investigated their inhibitory activities with bovine heart mitochondrial complex I. Our results indicate that the presence of either of the two hydroxy groups sufficiently sustains a potent inhibitory effect. Topics: Acetogenins; Animals; Cattle; Electron Transport Complex I; Enzyme Inhibitors; Fatty Alcohols; Furans; Hydroxyl Radical; Lactones; Mitochondria, Heart; Molecular Conformation; Molecular Structure; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Structure-Activity Relationship | 2004 |