acetaminophen glucuronide has been researched along with acetaminophen in 133 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (21.80) | 18.7374 |
| 1990's | 32 (24.06) | 18.2507 |
| 2000's | 40 (30.08) | 29.6817 |
| 2010's | 28 (21.05) | 24.3611 |
| 2020's | 4 (3.01) | 2.80 |
| Authors | Studies |
|---|---|
| Prescott, LF | 1 |
| Kalow, W; Patel, M; Tang, BK | 1 |
| Chow, SY; de Morais, SM; Wells, PG | 1 |
| Jia, XS; Klaassen, CD; Liu, J; Liu, YP; Madhu, C; Mao, Q | 1 |
| Brouwer, KL; Studenberg, SD | 2 |
| Ingebrigtsen, K; Lausund, P; Nafstad, I; Skoglund, LA | 1 |
| Cho, AM; Critchley, JA; Gin, T; Lau, GS; Lew, JK; Oh, TE; Yuen, PM | 1 |
| Davies, MH; Schnell, RC | 1 |
| Edwards, G; Mansor, SM; Roberts, PJ; Ward, SA | 1 |
| Lunte, CE; Puckett, DL; Scott, DO; Sorenson, LR; Steele, KL | 1 |
| Klaassen, CD; Madhu, C | 1 |
| Goon, D; Klaassen, CD | 1 |
| Brouwer, KL; Jones, JA | 1 |
| Bhargava, VO; Hirate, J; Horikoshi, I; Zhu, CY | 1 |
| Arisz, L; Koomen, GC; Krediet, RT; Schoots, AC; Struijk, DG | 1 |
| Nakamura, J; Podder, SK; Sasaki, H; Shibasaki, J | 2 |
| Comeau, AM; Ecobichon, DJ; Hidvegi, S; Varma, DR | 1 |
| Gee, D; Pannall, P; Ramakrishna, BS; Roberts-Thomson, IC; Roediger, WE; Weiss, A | 1 |
| Critchley, JA; Prescott, LF; Speirs, GC; Temple, RM; Winney, RJ | 1 |
| Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Jollow, DJ; Price, VF | 1 |
| Baba, S; Nakamura, J; Nakamura, T; Sasaki, H; Shibasaki, J | 1 |
| Corcoran, GB; Galinsky, RE; Shum, L; Wong, BK | 1 |
| Boroujerdi, M; McLaughlin, WJ | 1 |
| Greenblatt, DJ; Hellerstein, MK; Munro, HN | 1 |
| Hellerstein, MK; Munro, HN | 1 |
| Avenant, JC; Moncrieff, J; Sommers, DK | 1 |
| Flanagan, RJ; Prescott, LF; Roberts, I; Strang, J | 1 |
| Hjelle, JJ | 1 |
| Dills, RL; Klaassen, CD | 1 |
| Corcoran, GB; Galinsky, RE | 1 |
| Brzeznicka, EA; Hjelle, JJ; Klaassen, CD | 1 |
| Bales, JR; Nicholson, JK; Sadler, PJ; Timbrell, JA | 1 |
| Jung, D; Zafar, NU | 1 |
| Benet, LZ; Rudolph, AM; Wang, LH | 1 |
| Levy, G; Morris, ME | 1 |
| Hanawa, M; Iwai, M; Kaneniwa, N; Watari, N | 1 |
| Nash, RM; Passananti, GT; Penno, MB; Stein, L; Vesell, ES | 1 |
| Anderson, KE; Conney, AH; Kappas, A; Pantuck, CB; Pantuck, EJ; Wattenberg, LW | 1 |
| Hjelle, JJ; Klaassen, CD | 1 |
| Klaassen, CD; Siegers, CP | 1 |
| Aw, TY; Jones, DP | 1 |
| Rother, KI; Schwenk, WF | 1 |
| Kaminski, DR; Kane, RE; Li, AP | 1 |
| Critchley, JA; Lau, GS | 1 |
| Acharya, SK; Davies, MH; Elias, E; Mills, CO; Ngong, JM; Waring, RH; Weaver, JB; Yucesoy, M | 1 |
| Birt, DD; Grandjean, AC; Gwilt, PR; Lear, CL; Nagel, DL; Ruddon, RW; Tempero, MA | 1 |
| Martin, U; Prescott, LF; Temple, RM; Winney, RJ | 1 |
| Birkett, DJ; Miners, JO | 1 |
| Greenblatt, DJ; Harmatz, JS; Manis, M; Poorman, R; von Moltke, LL | 1 |
| Franklin, MR; Galinsky, RE; Raftogianis, RB | 1 |
| Kahl, JC; Schwenk, WF | 1 |
| Foxall, PJ; Lindon, JC; Nicholson, JK; Shockcor, JP; Unger, SE; Wilson, ID | 1 |
| Caddick, S; Farrant, RD; Lindon, JC; Nicholls, AW; Nicholson, JK; Wilson, ID | 1 |
| Kim, ND; Kwak, MK; Lee, MG; Lee, WI | 1 |
| Bruschi, SA; Eaton, DL; Kalhorn, T; Kelly, EJ; Nebert, DW; Nelson, SD; Tonge, RP | 1 |
| Bohnenstengel, F; Kroemer, HK; Sperker, B | 1 |
| Anand, KJ; Deinum, JT; Kuizenga, AJ; Okken, A; Quak, JM; Tibboel, D; van Dam, JG; van Lingen, RA | 1 |
| Alberti, A; Elia, M; Pirrone, P; Romano, C; Waring, RH | 1 |
| Evans, AM; Nation, RL; Sabordo, L; Sallustio, BC | 1 |
| Brouwer, KL; Jansen, PL; Turner, KC; Ward, ES; Xiong, H | 1 |
| Burchell, B; Findlay, K; Fisher, MB; Hall, SD; Thummel, KE; Vandenbranden, M; Wrighton, SA | 1 |
| Alkharfy, KM; Frye, RF | 1 |
| Aster, R; Bougie, D | 1 |
| Itoh, H; Nagano, T; Takeyama, M | 2 |
| Cole, SM; Jones, JG; Malloy, CR; Sherry, AD; Solomon, MA | 1 |
| Court, MH; Duan, SX; Greenblatt, DJ; Mackenzie, PI; Miners, JO; Patten, CJ; von Moltke, LL | 1 |
| Kulkarni, SG; Pegram, AA; Smith, PC | 1 |
| Raffa, RB | 1 |
| Brouwer, KL; Meier, PJ; Pollack, GM; Sugiyama, Y; Suzuki, H; Xiong, H | 1 |
| Kawakami, N; Ohta, M; Shimada, K; Yamato, S | 1 |
| Burgess, SC; Dean Sherry, A; Jones, JG; Malloy, CR; Margolis, D; Merritt, ME; Smith, E; Weis, B | 1 |
| Chen, C; Hennig, GE; Manautou, JE | 1 |
| Anderson, BJ; Holford, NH; Jansman, FG; Pluim, MA; Tibboel, D; van den Anker, JN; van der Marel, CD; van Lingen, RA | 1 |
| Franssila, S; Grigoras, K; Huikko, K; Kostiainen, R; Kotiaho, T; Mandel, F; Östman, P; Sauber, C | 1 |
| Cherrington, NJ; Klaassen, CD; Maher, JM; Slitt, AL | 1 |
| Burgess, SC; Malloy, CR; Margolis, D; Merritt, ME; Sherry, AD; Weis, BC; Wise, H | 1 |
| Evans, AM; Jensen, LS; Milne, RW; Valentine, J | 1 |
| Chung, JH; Jung, DW; Kim, SJ; Kim, YC; Lee, JY; Moon, CK; Park, HA | 1 |
| Reynolds, R; Segal, S; Wehrli, S; Yager, C | 1 |
| Allegaert, K; de Hoon, J; Devlieger, H; Tibboel, D; Vanhole, C; Verbesselt, R | 1 |
| Allegaert, K; Tibboel, D | 1 |
| Catania, VA; Luquita, MG; Mottino, AD; Ruiz, ML; Villanueva, SS; Vore, M | 1 |
| Chantharaksri, U; Fucharoen, P; Fucharoen, S; Howard, TA; Morales, NP; Sanvarinda, Y; Sirankapracha, P; Tankanitlert, J; Temsakulphong, A; Ware, RE | 1 |
| Baptista, C; Barosa, C; Barros, L; Bastos, M; Caldeira, MM; Carvalheiro, M; Fagulha, A; Jones, JG | 1 |
| Chantharaksri, U; Fucharoen, P; Fucharoen, S; Howard, TA; Morales, NP; Tankanitlert, J; Ware, RE | 1 |
| Allegaert, K; de Hoon, J; Debeer, A; Rayyan, M; Verbesselt, R | 1 |
| Catania, VA; Ikushiro, S; Luquita, MG; Mottino, AD; Ruiz, ML; Villanueva, SS | 1 |
| Boos, J; Hempel, G; Koling, S; Lanvers, C; Würthwein, G | 1 |
| Dawson, PA; Hewavitharana, AK; Lee, S; Markovich, D; Shaw, PN | 1 |
| Catania, VA; Ghanem, CI; Luquita, MG; Mottino, AD; Ruiz, ML; Villanueva, SS | 1 |
| Hickling, J; Kumara De Silva, R; Medlicott, NJ; Reith, D; Yang, L; Zacharias, M | 1 |
| Aleksunes, LM; Csanaky, IL; Klaassen, CD; Reisman, SA | 1 |
| Bengochea, LA; Catania, VA; Ghanem, CI; Llesuy, S; Luquita, M; Mottino, AD; Ruiz, ML; Villanueva, SS | 1 |
| Allegaert, K; van den Anker, JN; Vanhaesebrouck, S; Verbesselt, R | 1 |
| Baker, D; Clayton, TA; Everett, JR; Lindon, JC; Nicholson, JK | 1 |
| Beger, RD; Schnackenberg, LK; Sun, J | 1 |
| Wilson, ID | 1 |
| Barshop, NJ; Capparelli, EV; Lavine, JE; Schwimmer, JB; Sirlin, CB | 1 |
| Aantaa, R; Kuusniemi, K; Liukas, A; Neuvonen, PJ; Niemi, M; Olkkola, KT; Virolainen, P | 1 |
| Kulkarni, SR; Li, L; Slitt, AL; Xu, J | 1 |
| Gao, D; Lin, JM; Liu, W; Mao, S; Wei, H | 1 |
| Dai, LB; Li, HD; Tan, QY; Wang, F; Yan, M; Zhu, RH | 1 |
| McLachlan, AJ; Rittau, AM | 1 |
| Bienert, A; Grabowski, T; Gracz, J; Grześkowiak, E; Kamińska, A; Olszewski, J; Wolc, A | 1 |
| Doherty, JP; Kulmatycki, K; Li, W; Smith, HT; Tse, FL | 1 |
| Allegaert, K; de Hoon, J; Knibbe, CA; Kulo, A; Lewi, L; Peeters, MY; Smits, A; van de Velde, M; Verbesselt, R | 1 |
| Barosa, C; Basu, A; Basu, R; Jones, JG; Rizza, R | 1 |
| Chary, S; Curran, N; Medlicott, NJ; Owens, KH; Reith, DM; Thompson-Fawcett, M; Zacharias, M | 1 |
| Böhlke, M; Ganetsky, M; Guatam, S; LeDuc, B; Pereira, L; Salhanick, SD; Williams, D | 1 |
| Araújo, AN; Delerue-Matos, C; Montenegro, MC; Paíga, P; Pena, A; Santos, LH | 1 |
| Cogger, VC; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, BE; Le Couteur, DG; Mach, J; McKenzie, C | 1 |
| Liu, X; Wang, Q; Xu, R; Yang, J; Zang, M; Zhang, J | 1 |
| Adnet, F; Bossard, AE; Bouchemal, N; Fleyfel, M; Galinski, M; Hamza, L; Le Moyec, L; Racine, SX | 1 |
| Biczysko-Murawa, A; Grabowski, T; Grześkowiak, E; Karbownik, A; Matuszewski, M; Połom, W; Sobańska, K; Szałek, E; Wolc, A | 1 |
| Barnes, DM; Evans, M; Paterson, E | 1 |
| Kadowaki, D; Otagiri, M; Seo, H; Taguchi, K; Tokuno, M; Yamasaki, K | 1 |
| A-Kader, HH; Bataille, AM; Campion, SN; Canet, MJ; Cherrington, NJ; Erickson, RP; Ferreira, DW; Hardwick, RN; Manautou, JE; Merrell, MD; Xanthakos, SA | 1 |
| Barosa, C; Carvalho, F; Jones, J; Kahl, S; Roden, M | 1 |
| Court, MH; Epstein, CR; Giesing, D; Greenblatt, DJ; Harmatz, JS; Kadota, T; Kurosaki, C; Nakagawa, Y; Nakamura, T; Zhao, Y | 1 |
| Allegaert, K; Danhof, M; de Hoon, J; Knibbe, CA; Krekels, EH; Tibboel, D; van Ham, S | 1 |
| Kelley, DE; Previs, SF | 1 |
| Achterbergh, R; Lammers, LA; Mathôt, RA; Pistorius, MC; Romijn, JA | 1 |
| Hu, W; Jiang, X; Li, R; Wang, L; Zeng, J; Zhang, X | 1 |
| Ghallab, A; Hassan, R; Hengstler, JG; Kuepfer, L; Sezgin, S; Spiteller, M; Zühlke, S | 1 |
| Amant, F; Annaert, P; Conings, S; Paulus, J; Qi, B; Tseke, F; Van Calsteren, K; Van den Broeck, A | 1 |
| Azuine, RE; Hong, X; Hou, W; Ji, Y; Pearson, C; Riley, A; Wang, G; Wang, X; Zhang, Y; Zuckerman, B | 1 |
| Fumoto, S; Miyamoto, H; Nishida, K; Tokunaga, A | 1 |
| He, D; He, J; Lin, R; Tang, L; Wang, T; Wu, Y; Yang, P; Zhang, Y | 1 |
| Azuma, M; Harada, H; Hayashi, T; Ijiri, Y; Kagawa, Y; Kato, R; Kawai, Y; Kusanagi, M; Noda, T; Ozato, Y; Tanaka, K; Uryu, K; Yamamoto, K; Yamamoto, M | 1 |
1 review(s) available for acetaminophen glucuronide and acetaminophen
| Article | Year |
|---|---|
Kinetics and metabolism of paracetamol and phenacetin.
Topics: Acetaminophen; Administration, Oral; Adult; Animals; Biotransformation; Humans; Intestinal Absorption; Kinetics; Metabolic Clearance Rate; Phenacetin; Tissue Distribution | 1980 |
13 trial(s) available for acetaminophen glucuronide and acetaminophen
| Article | Year |
|---|---|
The adverse influence of pregnancy upon sulphation: a clue to the pathogenesis of intrahepatic cholestasis of pregnancy?
Topics: Acetaminophen; Adult; Arylsulfotransferase; Blood Platelets; Cholestasis; Contraceptives, Oral; Estrogens; Female; Humans; Pregnancy; Pregnancy Complications; Sulfates | 1994 |
Cisapride raises the bioavailability of paracetamol by inhibiting its glucuronidation in man.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Biological Availability; Cisapride; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Agents; Glucuronosyltransferase; Humans; Male; Statistics, Nonparametric | 2001 |
Effect of nizatidine on paracetamol and its metabolites in human plasma.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Area Under Curve; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Histamine H2 Antagonists; Humans; Male; Nizatidine | 2002 |
Paracetamol and metabolite pharmacokinetics in infants.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Infant; Male; Metabolic Clearance Rate; Pain, Postoperative | 2003 |
Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates.
Topics: Acetaminophen; Age Factors; Analgesics; Body Weight; Chromatography, High Pressure Liquid; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Linear Models; Metabolic Clearance Rate; Multivariate Analysis; Urination | 2005 |
Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Antineoplastic Agents; Benzoquinones; Child; Child, Preschool; Cysteine; Drug Administration Schedule; Drug Interactions; Humans; Imines; Infant; Neoplasms; Oxidation-Reduction | 2007 |
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Bacteria; Cresols; Gastrointestinal Tract; Host-Pathogen Interactions; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Sulfates; Sulfuric Acid Esters; Young Adult | 2009 |
Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum.
Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Delivery, Obstetric; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Pain; Pain Measurement; Postpartum Period; Pregnancy | 2013 |
The pharmacokinetic profile of intravenous paracetamol in adult patients undergoing major abdominal surgery.
Topics: Abdomen; Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Biotransformation; Female; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Postoperative Period | 2012 |
Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chemical and Drug Induced Liver Injury; Cross-Over Studies; Cytochrome P-450 CYP2E1 Inhibitors; Dosage Forms; Excipients; Female; Humans; Male; Propylene Glycol; Sulfates | 2013 |
An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects.
Topics: Acetaminophen; Acetylcysteine; Adult; Area Under Curve; Dietary Supplements; Estradiol; gamma-Glutamyltransferase; Humans; Inactivation, Metabolic; Liver; Male; Pilot Projects; Plant Extracts; Raphanus; Treatment Outcome; Up-Regulation | 2014 |
Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen.
Topics: Acetaminophen; Adult; Amides; Analgesics, Non-Narcotic; Antiviral Agents; Drug Interactions; Female; Humans; In Vitro Techniques; Inhibitory Concentration 50; Male; Middle Aged; Pyrazines; Young Adult | 2015 |
Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants.
Topics: Acetaminophen; Body Weight; Child Development; Computer Simulation; Female; Humans; Infant; Infant, Newborn; Male; Metabolic Clearance Rate; Models, Biological; Up-Regulation | 2015 |
119 other study(ies) available for acetaminophen glucuronide and acetaminophen
| Article | Year |
|---|---|
Variability of acetaminophen metabolism in Caucasians and Orientals.
Topics: Acetaminophen; Asian People; Female; Genetic Variation; Gilbert Disease; Humans; Male; Sulfates; White People | 1992 |
Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Biotransformation; Glucosyltransferases; Heterozygote; Jaundice; Male; Metabolism, Inborn Errors; Phenotype; Rats; Rats, Inbred Strains | 1992 |
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Inactivation, Metabolic; Male; Mice; Microsomes, Liver; Oleanolic Acid; Saponins | 1992 |
Impaired biliary excretion of acetaminophen glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo phenobarbital pretreatment.
Topics: Acetaminophen; Animals; Biliary Tract; Chromatography, High Pressure Liquid; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Plasma concentration of paracetamol and its major metabolites after p.o. dosing with paracetamol or concurrent administration of paracetamol and its N-acetyl-DL-methionine ester in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Male; Mice; Mice, Inbred Strains | 1992 |
Gastric emptying in the postpartum period.
Topics: Absorption; Acetaminophen; Adult; Analysis of Variance; Fasting; Female; Gastric Emptying; Humans; Postpartum Period; Time Factors | 1991 |
Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. II. Competitive shunt in metabolism via glucuronidation.
Topics: Acetaminophen; Animals; Cricetinae; Glutathione; Liver; Male; Mesocricetus; Models, Biological; Pyrazines; Schistosomicides; Thiones; Thiophenes; Uridine Diphosphate Glucuronic Acid | 1991 |
The effect of malaria infection on paracetamol disposition in the rat.
Topics: Acetaminophen; Animals; Bile; Half-Life; Inactivation, Metabolic; Liver; Malaria; Male; Mice; Rats | 1991 |
In vivo microdialysis sampling for pharmacokinetic investigations.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Dialysis; Dose-Response Relationship, Drug; Microchemistry; Rats; Rats, Inbred Strains; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1991 |
Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biliary Tract; Cricetinae; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; L-Iditol 2-Dehydrogenase; Liver; Male; Mesocricetus; Pregnenolone Carbonitrile | 1991 |
Dose-dependent intestinal glucuronidation and sulfation of acetaminophen in the rat in situ.
Topics: Acetaminophen; Animals; Biotransformation; Dose-Response Relationship, Drug; Glucose; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains | 1990 |
Altered hepatobiliary disposition of acetaminophen metabolites after phenobarbital pretreatment and renal ligation: evidence for impaired biliary excretion and a diffusional barrier.
Topics: Acetaminophen; Animals; Bile; Bile Ducts; Diffusion; Kidney; Ligation; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
First-pass metabolism of acetaminophen in rats after low and high doses.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Isolation, identification, and analysis of 4-acetylaminophenol-glucuronide in body fluids of dialyzed renal patients; a molecular mass marker for peritoneal diffusive transport.
Topics: Acetaminophen; Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Dialysis Solutions; Diffusion; Gas Chromatography-Mass Spectrometry; Humans; Kidney Failure, Chronic; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 1990 |
Disposition of phenacetin in rabbits pretreated orally and intraperitoneally with 3,4-benzpyrene.
Topics: Acetaminophen; Administration, Oral; Animals; Benzo(a)pyrene; Enzyme Induction; Injections, Intraperitoneal; Liver; Male; Phenacetin; Rabbits | 1989 |
Acetaminophen metabolism in vivo by pregnant, fetal, and neonatal guinea pigs.
Topics: Acetaminophen; Animals; Animals, Newborn; Biotransformation; Female; Fetus; Guinea Pigs; Pregnancy; Pregnancy, Animal | 1989 |
Estimation of phenolic conjugation by colonic mucosa.
Topics: Acetaminophen; Colon; Dialysis; Humans; Intestinal Mucosa; Phenols; Rectum | 1989 |
Paracetamol disposition and metabolite kinetics in patients with chronic renal failure.
Topics: Acetaminophen; Adult; Aged; Female; Half-Life; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Time Factors | 1989 |
Intestinal first-pass metabolism of phenacetin in rabbits pretreated orally and intraperitoneally with 3,4-benzpyrene.
Topics: Acetaminophen; Administration, Oral; Animals; Benzo(a)pyrene; Enzyme Induction; Injections, Intraperitoneal; Intestinal Mucosa; Intestine, Small; Mesenteric Veins; Phenacetin; Rabbits | 1989 |
Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo.
Topics: Acetaminophen; Alanine; Animals; Anisoles; Aspartate Aminotransferases; Biotransformation; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury; Female; Glucuronosyltransferase; Glutathione; Kinetics; Liver Diseases; Mice; Protein Binding; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid | 1986 |
Mechanism of decreased acetaminophen glucuronidation in the fasted rat.
Topics: Acetaminophen; Animals; Blood Glucose; Fasting; Glucuronosyltransferase; Liver; Liver Glycogen; Male; NAD; Rats; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid | 1988 |
A method for the preparation of calibration curves for acetaminophen glucuronide and acetaminophen sulfate in rabbit urine without use of authentic compounds in high-performance liquid chromatography.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Male; Rabbits; Reference Values | 1987 |
Acetaminophen sulfation deficit in obese rats overfed an energy-dense cafeteria diet.
Topics: Acetaminophen; Animals; Biotransformation; Kinetics; Male; Obesity; Rats; Rats, Inbred Strains | 1987 |
BHA (2(3)-tert-butyl-4-hydroxyanisole)-mediated modulation of acetaminophen phase II metabolism in vivo in Fisher 344 rats.
Topics: Acetaminophen; Animals; Bile; Butylated Hydroxyanisole; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred F344; Solubility | 1987 |
Glycoconjugates as noninvasive probes of intrahepatic metabolism: I. Kinetics of label incorporation with evidence of a common precursor UDP-glucose pool for secreted glycoconjugates.
Topics: Acetaminophen; Animals; Galactose; Gluconeogenesis; Glucose; Glycoconjugates; Kinetics; Liver; Male; Orosomucoid; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars | 1987 |
Glycoconjugates as noninvasive probes of intrahepatic metabolism: II. Application to measurement of plasma alpha 1-acid glycoprotein turnover during inflammation.
Topics: Acetaminophen; Animals; Galactose; Glycoconjugates; Inflammation; Kinetics; Liver; Male; Orosomucoid; Rats; Rats, Inbred Strains; Turpentine | 1987 |
Paracetamol conjugation: an interethnic and dietary study.
Topics: Acetaminophen; Adult; Black People; Diet; Humans; Male; Sulfates; White People | 1987 |
Toxicological studies in a Distalgesic addict.
Topics: Acetaminophen; Adult; Dextropropoxyphene; Drug Combinations; Humans; Kinetics; Male; Substance-Related Disorders | 1986 |
Hepatic UDP-glucuronic acid regulation during acetaminophen biotransformation in rats.
Topics: Acetaminophen; Animals; Biotransformation; Hydrogen-Ion Concentration; Kinetics; Lactates; Lactic Acid; Liver; Liver Glycogen; Male; NAD; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Salicylamides; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid; Uridine Diphosphate Sugars | 1986 |
Effect of reduced hepatic energy state on acetaminophen conjugation in rats.
Topics: Acetaminophen; Adenine Nucleotides; Animals; Bile; Energy Metabolism; Ethionine; Fructose; Kinetics; Liver; Male; Phosphates; Rats; Rats, Inbred Strains; Uracil Nucleotides; Uridine Diphosphate Glucose | 1986 |
Influence of advanced age on the formation and elimination of acetaminophen metabolites by male rats.
Topics: Acetaminophen; Aging; Animals; Biotransformation; Kinetics; Male; Rats; Rats, Inbred F344 | 1986 |
Comparison of the effects of sodium sulfate and N-acetylcysteine on the hepatotoxicity of acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Dose-Response Relationship, Drug; Glutathione; Half-Life; Liver; Male; Mice; Mice, Inbred Strains; Phosphoadenosine Phosphosulfate; Sulfates | 1986 |
A high resolution proton nuclear magnetic resonance approach to the study of hepatocyte and drug metabolism. Application to acetaminophen.
Topics: Acetaminophen; Animals; Deuterium; In Vitro Techniques; Kinetics; Liver; Magnetic Resonance Spectroscopy; Rats; Rats, Inbred Strains | 1985 |
Micro high-performance liquid chromatographic assay of acetaminophen and its major metabolites in plasma and urine.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Humans | 1985 |
Distribution and fate of acetaminophen conjugates in fetal lambs in utero.
Topics: Acetaminophen; Animals; Blood Proteins; Female; Fetus; Glomerular Filtration Rate; Half-Life; Inulin; Kidney; Kinetics; Pregnancy; Sheep; Time Factors | 1985 |
Renal clearance and serum protein binding of acetaminophen and its major conjugates in humans.
Topics: Acetaminophen; Adult; Albumins; Blood Proteins; Creatinine; Female; Humans; Kidney; Male; Protein Binding; Ultrafiltration | 1984 |
Pharmacokinetic study of the enterohepatic circulation of acetaminophen glucuronide in rats.
Topics: Acetaminophen; Animals; Bile; Bile Ducts; Enterohepatic Circulation; Injections, Intravenous; Kinetics; Liver; Male; Models, Biological; Rats; Rats, Inbred Strains | 1984 |
Sources of interindividual variations in acetaminophen and antipyrine metabolism.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Antipyrine; Biotransformation; Chromatography, High Pressure Liquid; Environment; Female; Half-Life; Humans; Kinetics; Male; Pregnancy; Twins; Twins, Dizygotic; Twins, Monozygotic | 1984 |
Effect of brussels sprouts and cabbage on drug conjugation.
Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Humans; Kinetics; Male; Oxazepam; Vegetables | 1984 |
Glucuronidation and biliary excretion of acetaminophen in rats.
Topics: Acetaminophen; Animals; Bile; Biotransformation; Dose-Response Relationship, Drug; Kinetics; Male; Rats; Rats, Inbred Strains | 1984 |
Biliary excretion of acetaminophen in ureter-ligated rats.
Topics: Acetaminophen; Animals; Bile; Kidney Failure, Chronic; Ligation; Male; Rats; Rats, Inbred Strains; Sulfuric Acids; Ureter | 1984 |
Intracellular inhibition of UDP-glucose dehydrogenase during ethanol oxidation.
Topics: Acetaminophen; Aerobiosis; Animals; Carbohydrate Dehydrogenases; Ethanol; Kinetics; Liver; Male; Oxygen Consumption; Rats; Uridine Diphosphate Glucose Dehydrogenase | 1983 |
Hepatic glycogen accurately reflected by acetaminophen glucuronide in dogs refed after fasting.
Topics: Acetaminophen; Animal Feed; Animals; Carbon Isotopes; Carbon Radioisotopes; Dogs; Fasting; Female; Glucose; Glycogen; Liver; Tritium; Uridine Diphosphate Glucose | 1995 |
Sulfation and glucuronidation of acetaminophen by human hepatocytes cultured on Matrigel and type 1 collagen reproduces conjugation in vivo.
Topics: Acetaminophen; Adult; Biocompatible Materials; Cells, Cultured; Collagen; Drug Combinations; Female; Humans; Laminin; Liver; Male; Middle Aged; Proteoglycans; Sex Characteristics; Sulfuric Acids | 1995 |
The estimation of paracetamol and its major metabolites in both plasma and urine by a single high-performance liquid chromatography assay.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Cysteine; Humans; Spectrophotometry, Ultraviolet | 1994 |
The effect of garlic extract on human metabolism of acetaminophen.
Topics: Acetaminophen; Adult; Allyl Compounds; Carcinogens; Garlic; Half-Life; Humans; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Neoplasms; Plant Extracts; Plants, Medicinal; Sulfides | 1994 |
The disposition of paracetamol and its conjugates during multiple dosing in patients with end-stage renal failure maintained on haemodialysis.
Topics: Acetaminophen; Administration, Oral; Adult; Cysteine; Drug Administration Schedule; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 1993 |
The misuse of urinary metabolite excretion data in drug metabolism studies.
Topics: Acetaminophen; Asian People; Genetic Variation; Humans; White People | 1993 |
Hepatic disposition of acetaminophen and metabolites. Pharmacokinetic modeling, protein binding and subcellular distribution.
Topics: Acetaminophen; Animals; Blood Proteins; Cell Nucleus; Cytosol; Liver; Lysosomes; Male; Microsomes, Liver; Mitochondria, Liver; Protein Binding; Rats; Rats, Sprague-Dawley | 1993 |
Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; In Vitro Techniques; Lorazepam; Macaca; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Probenecid; Rats; Rats, Sprague-Dawley | 1993 |
Effect of lipid-free total parenteral nutrition on hepatic drug conjugation in rats.
Topics: Acetaminophen; Animals; Enteral Nutrition; Glucuronosyltransferase; Liver; Male; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley | 1996 |
Acetaminophen glucuronidation accurately reflects gluconeogenesis in fasted dogs.
Topics: Acetaminophen; Animals; Biomarkers; Dogs; Fasting; Female; Glucose; Uridine Diphosphate Glucose | 1996 |
Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Xenobiotics | 1996 |
NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat.
Topics: Acetaminophen; Acetylation; Animals; Deuterium; Magnetic Resonance Spectroscopy; Male; Phenacetin; Rats; Rats, Sprague-Dawley | 1997 |
Metabolic changes of acetaminophen after intravenous administration to rats pretreated with 2-(allylthio)pyrazine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Inactivation, Metabolic; Male; Pyrazines; Rats; Rats, Sprague-Dawley | 1998 |
Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Liver; Liver Diseases; Male; Mice; Mice, Knockout | 1998 |
In vitro cleavage of paracetamol glucuronide by human liver and kidney beta-glucuronidase: determination of paracetamol by capillary electrophoresis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Electrophoresis, Capillary; Glucuronidase; Humans; In Vitro Techniques; Kidney; Kinetics; Liver; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1999 |
Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gestational Age; Half-Life; Humans; Infant, Newborn; Infant, Premature; Male; Pain Measurement; Regression Analysis; Statistics, Nonparametric; Time Factors | 1999 |
Sulphation deficit in "low-functioning" autistic children: a pilot study.
Topics: Acetaminophen; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Autistic Disorder; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Food; Humans; Male; Metabolism, Inborn Errors; Pilot Projects; Sulfates | 1999 |
Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil-beta-D-glucuronide: effects of clofibric acid, acetaminophen, and acetaminophen glucuronide.
Topics: Acetaminophen; Animals; Biological Transport; Clofibric Acid; Gemfibrozil; Glucuronates; Liver; Male; Perfusion; Rats; Rats, Sprague-Dawley | 2000 |
Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Bicarbonates; Biliary Tract; Biological Transport; Cell Membrane; Hydrogen-Ion Concentration; Liver; Male; Membrane Potentials; Membrane Transport Proteins; Models, Biological; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2000 |
Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank.
Topics: Acetaminophen; Alamethicin; Alleles; Estradiol; Genetic Variation; Genotype; Glucuronosyltransferase; Homozygote; Humans; Intestines; Kidney; Kinetics; Liver; Lung; Metabolic Clearance Rate; Microsomes, Liver; Morphine; Morphine Derivatives; Mutation; Promoter Regions, Genetic; Tissue Banks; Tissue Distribution | 2000 |
High-performance liquid chromatographic assay for acetaminophen glucuronide in human liver microsomes.
Topics: Acetaminophen; Calibration; Chromatography, High Pressure Liquid; Humans; Microsomes, Liver; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2001 |
Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen.
Topics: Acetaminophen; Adult; Aged; Antibodies; Blood Platelets; Female; Glucuronides; Humans; Male; Middle Aged; Naproxen; Platelet Glycoprotein GPIIb-IIIa Complex; Purpura, Thrombocytopenic, Idiopathic | 2001 |
An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans.
Topics: Acetaminophen; Adult; Blood Glucose; Carbon Isotopes; Citric Acid Cycle; Deuterium; Female; Gluconeogenesis; Glucose; Glutamine; Humans; Hydrogen; Kinetics; Liver; Liver Glycogen; Magnetic Resonance Spectroscopy; Male; Models, Biological; Phosphoenolpyruvate; Propionates; Reference Values; Time Factors; Water | 2001 |
Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.
Topics: Acetaminophen; Glucuronosyltransferase; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Sex Factors; Statistics as Topic | 2001 |
Disposition of acetaminophen and indocyanine green in cystic fibrosis-knockout mice.
Topics: Acetaminophen; Animals; Cystic Fibrosis; Indocyanine Green; Male; Mice; Mice, Knockout; Models, Animal; Organ Specificity | 2000 |
Acetaminophen and metabolite: lack of effect on nitric oxide synthase (constitutive or inducible).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats | 2002 |
Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.
Topics: Acetaminophen; Animals; Bile; Cell Line; In Vitro Techniques; Liver; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Phenobarbital; Rats; Rats, Wistar; Transfection; Transport Vesicles | 2002 |
Analysis of acetaminophen glucuronide conjugate accompanied by adduct ion production by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
Topics: Acetaminophen; Atmospheric Pressure; Gas Chromatography-Mass Spectrometry; Technology, Pharmaceutical | 2003 |
Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.
Topics: Acetaminophen; Administration, Oral; Adult; Carbon Isotopes; Deuterium; Humans; Isomerism; Liver; Magnetic Resonance Spectroscopy; Molecular Structure; Propionates | 2003 |
Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats.
Topics: Acetaminophen; Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Hyperbilirubinemia; Liver; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Rats, Wistar | 2003 |
Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs.
Topics: Acetaminophen; Air Ionization; Atmospheric Pressure; Carboxylic Acids; Ketoprofen; Mass Spectrometry; Midazolam; Molecular Structure; Naphthaleneacetic Acids; Naphthalenes; Naphthoquinones; Pharmaceutical Preparations; Propranolol; Silicon; Testosterone | 2003 |
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Topics: Acetaminophen; Allyl Compounds; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Branched DNA Signal Amplification Assay; Drug Resistance, Multiple; Kidney; Liver; Male; Mitochondrial Proteins; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Ribosomal Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Stilbenes; Sulfides; Thiones; Thiophenes; Time Factors | 2003 |
Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.
Topics: Acetaminophen; Blood Glucose; Carbon Isotopes; Citric Acid Cycle; Deuterium; Fasting; Female; Gluconeogenesis; Glucose; Glycerol; HIV Protease Inhibitors; HIV-Associated Lipodystrophy Syndrome; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Plasma; Propionates; Water | 2004 |
The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Humans | 2004 |
Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bile; Cricetinae; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Male; Mesocricetus; Taurine; Time Factors | 2004 |
Pathways of galactose metabolism by galactosemics: evidence for galactose conversion to hepatic UDPglucose.
Topics: Acetaminophen; Adult; Amino Acid Substitution; Blood Glucose; Carbon Dioxide; Carbon Radioisotopes; Galactose; Galactosemias; Heterozygote; Homozygote; Humans; Liver; Magnetic Resonance Spectroscopy; Male; Mutation; Uridine Diphosphate Glucose; UTP-Hexose-1-Phosphate Uridylyltransferase | 2006 |
Comments on "shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats".
Topics: Acetaminophen; Animals; Bile; Humans; Metabolic Detoxication, Phase II; Rats | 2006 |
Ethynylestradiol increases expression and activity of rat liver MRP3.
Topics: Acetaminophen; Animals; ATP-Binding Cassette Transporters; Bile; Ethinyl Estradiol; Liver; Male; Multidrug Resistance-Associated Proteins; Perfusion; Rats; Rats, Wistar; Time Factors; Up-Regulation | 2006 |
A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients.
Topics: Acetaminophen; Adult; Area Under Curve; beta-Thalassemia; Bilirubin; Cysteine; Female; Glucuronosyltransferase; Humans; Male; Middle Aged | 2006 |
Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen.
Topics: Acetaminophen; Adult; Body Water; Deuterium; Diabetes Mellitus, Type 1; Fasting; Female; Food; Fructosephosphates; Glucose-6-Phosphate; Glycogen; Humans; Kinetics; Liver; Magnetic Resonance Spectroscopy; Male | 2006 |
Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia/HbE.
Topics: Acetaminophen; Adult; Analgesics; Area Under Curve; Asian People; beta-Thalassemia; Female; Glucuronosyltransferase; Half-Life; Hemoglobin E; Humans; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Genetic | 2007 |
Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Feasibility Studies; Glucuronosyltransferase; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Isoenzymes; Liver; Reproducibility of Results; Substrate Specificity; Tramadol | 2007 |
Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2.
Topics: Acetaminophen; Animals; Anion Transport Proteins; Antiporters; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Cholestasis, Intrahepatic; Ethinyl Estradiol; Gene Expression; Glucuronosyltransferase; Glutathione; Liver; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organ Size; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; SLC4A Proteins; Spironolactone; Up-Regulation | 2007 |
Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Male; Mice; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats.
Topics: Acetaminophen; Animals; ATP-Binding Cassette Transporters; Bile Ducts; Dose-Response Relationship, Drug; Intestinal Mucosa; Kidney; Ligation; Liver; Male; Multidrug Resistance-Associated Proteins; Rats; Rats, Wistar | 2008 |
Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cysteine; Dose-Response Relationship, Drug; Female; Humans; Male; Molecular Structure; Pain; Time; Young Adult | 2009 |
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Animals; Bile; Biotransformation; Carrier Proteins; Cytoskeletal Proteins; Gene Knockdown Techniques; Guinea Pigs; Kelch-Like ECH-Associated Protein 1; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2 | 2009 |
Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP-Binding Cassette Transporters; Blotting, Western; Charcoal; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione; Injections, Intraperitoneal; Liver; Male; Microscopy, Fluorescence; Multidrug Resistance-Associated Proteins; Oxidative Stress; Rats; Rats, Wistar | 2009 |
In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age.
Topics: Acetaminophen; Age Factors; Bilirubin; Glucuronides; Glucuronosyltransferase; Humans; Infant, Newborn; Metabolic Clearance Rate; Morphine; Polymorphism, Genetic; Propofol | 2009 |
Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Creatine; Dose-Response Relationship, Drug; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Metabolomics; Principal Component Analysis; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Sulfates | 2009 |
Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Bacteria; Cresols; Gastrointestinal Tract; Host-Pathogen Interactions; Humans; Sulfates; Sulfuric Acid Esters | 2009 |
Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease.
Topics: Acetaminophen; Adolescent; Case-Control Studies; Child; Fatty Liver; Glucuronosyltransferase; Humans; Liver; Male; Non-alcoholic Fatty Liver Disease; Statistics, Nonparametric | 2011 |
Pharmacokinetics of intravenous paracetamol in elderly patients.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Analgesia; Analgesics, Non-Narcotic; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Female; Genotype; Glomerular Filtration Rate; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Sex Characteristics; Young Adult | 2011 |
UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Enzyme Induction; Fasting; Fatty Liver; Food Deprivation; Glucuronides; Glucuronosyltransferase; Isoenzymes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Microsomes, Liver; Obesity; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Up-Regulation | 2012 |
Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection.
Topics: Acetaminophen; Bioreactors; Cell Survival; Equipment Design; Glucuronosyltransferase; Hep G2 Cells; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Microfluidic Analytical Techniques; Microsomes, Liver; Pharmaceutical Preparations; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Toxicity Tests | 2012 |
Simultaneous quantitative determination of paracetamol and its glucuronide conjugate in human plasma and urine by liquid chromatography coupled to electrospray tandem mass spectrometry: application to a clinical pharmacokinetic study.
Topics: Acetaminophen; Adult; Chromatography, Liquid; Humans; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Investigating paracetamol pharmacokinetics using venous and capillary blood and saliva sampling.
Topics: Acetaminophen; Adult; Area Under Curve; Capillaries; Chromatography, High Pressure Liquid; Female; Humans; Middle Aged; Reference Values; Reproducibility of Results; Saliva; Veins; Young Adult | 2012 |
Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan.
Topics: Acetaminophen; Alloxan; Analgesics, Non-Narcotic; Animals; Aqueous Humor; Area Under Curve; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Eye; Injections, Intravenous; Metabolic Clearance Rate; Rabbits; Tissue Distribution | 2012 |
Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites in human dried blood spot samples collected by subjects in a pilot clinical study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, Reverse-Phase; Dried Blood Spot Testing; Humans; Limit of Detection; Methanol; Pilot Projects; Reference Standards; Solid Phase Extraction; Tandem Mass Spectrometry | 2012 |
Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method.
Topics: Acetaminophen; Adult; Blood Glucose; Deuterium; Female; Gluconeogenesis; Glycogenolysis; Humans; Magnetic Resonance Spectroscopy; Male; Prediabetic State; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity | 2013 |
Development of a simple analytical method for the simultaneous determination of paracetamol, paracetamol-glucuronide and p-aminophenol in river water.
Topics: Acetaminophen; Aminophenols; Chromatography, High Pressure Liquid; Limit of Detection; Linear Models; Portugal; Reproducibility of Results; Rivers; Solid Phase Extraction; Water Pollutants, Chemical | 2013 |
The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.
Topics: Acetaminophen; Aging; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver; Male; NF-E2-Related Factor 2; Rats; Rats, Inbred F344 | 2014 |
Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Glycyrrhizic Acid; Hepatobiliary Elimination; Injections, Intraperitoneal; Liver; Male; Rats, Sprague-Dawley; Silybin; Silymarin; Spironolactone; Time Factors | 2014 |
Detection and follow-up, after partial liver resection, of the urinary paracetamol metabolites by proton NMR spectroscopy.
Topics: Acetaminophen; Analgesics; Benzoquinones; Female; Humans; Imines; Liver; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2014 |
The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide.
Topics: Acetaminophen; Animals; Area Under Curve; Drug Interactions; Indoles; Male; Pyrroles; Rabbits; Sunitinib | 2015 |
Establishment of a model of acetaminophen-induced hepatotoxicity in different weekly-aged ICR mice.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Animals; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred ICR | 2015 |
Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bile Canaliculi; Biotransformation; Child; Cohort Studies; Fatty Liver; Female; Humans; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Pilot Projects; Protein Transport; Up-Regulation | 2015 |
Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water.
Topics: Acetaminophen; Adult; Blood Glucose; Body Water; Deuterium; Gluconeogenesis; Glycogenolysis; Humans; Liver; Magnetic Resonance Spectroscopy; Male; Water; Young Adult | 2015 |
Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions.
Topics: Acetaminophen; Acetates; Blood Glucose; Carbon Isotopes; Citric Acid Cycle; Fatty Liver; Glutamic Acid; Humans; Liver; Metabolic Flux Analysis; Mitochondria; Mitochondria, Liver; Oxidation-Reduction; Propionates; Radioactive Tracers | 2015 |
Quantitative Method for Simultaneous Analysis of Acetaminophen and 6 Metabolites.
Topics: Acetaminophen; Aminophenols; Calibration; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Plasma; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
A reliable LC-MS/MS method for the quantification of N-acetyl-p-benzoquinoneimine, acetaminophen glutathione and acetaminophen glucuronide in mouse plasma, liver and kidney: Method validation and application to a pharmacokinetic study.
Topics: Acetaminophen; Animals; Benzoquinones; Chromatography, Liquid; Imines; Limit of Detection; Linear Models; Mice; Mice, Inbred ICR; Reproducibility of Results; Tandem Mass Spectrometry; Tissue Distribution | 2018 |
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.
Topics: Acetaminophen; Animals; Benzoquinones; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Glutathione; Imines; Liver; Male; Mice, Inbred C57BL; Spatio-Temporal Analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
Transplacental transport of paracetamol and its phase II metabolites using the ex vivo placenta perfusion model.
Topics: Acetaminophen; Adult; Female; Fetus; Gestational Age; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy | 2019 |
Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood.
Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Biomarkers; Child; Female; Fetal Blood; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Risk Factors; Young Adult | 2020 |
Effect of Chronic Kidney Disease on Hepatic Clearance of Drugs in Rats.
Topics: Acetaminophen; Adenine; Administration, Intravenous; Animals; Cytochrome P-450 CYP3A; Disease Models, Animal; Glucuronosyltransferase; Hepatobiliary Elimination; Humans; Indocyanine Green; Kidney; Kidney Function Tests; Liver; Male; Metabolic Clearance Rate; Midazolam; Rats; Rats, Wistar; Renal Elimination; Renal Insufficiency, Chronic | 2020 |
Individual variability in human urinary metabolites identifies age-related, body mass index-related, and sex-related biomarkers.
Topics: Acetaminophen; Adult; Biological Variation, Population; Biomarkers; Dehydroepiandrosterone Sulfate; Female; Humans; Male; Middle Aged; Urinalysis | 2021 |
Decreased plasma acetaminophen glucuronide/acetaminophen concentration ratio warns the onset of acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Humans; Liver; Rats | 2022 |