acetaminophen and zidovudine

acetaminophen has been researched along with zidovudine in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (35.14)	18.2507
2000's	15 (40.54)	29.6817
2010's	9 (24.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Chang, TK; Ensom, MH; Kiang, TK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kamali, F; Rawlins, MD	1
Back, DJ; Edwards, G; Ismail, S	1
Ameer, B; James, MO; Saleh, J	1
Goetz, MB; Shriner, K	1
Back, DJ; Breckenridge, AM; Sim, SM	1
Cretton, EM; Sommadossi, JP	1
Antoniskis, D; Cohen, J; Ko, R; Koda, R; Leedom, J; Nicoloff, J; Sattler, FR; Shields, M	1
Nicholas, SW	1
Benet, LZ; Flynn, NF; Goldstein, E; Inciardi, JF; King, JH; Steffe, EM; Tonjes, TS	1
Beijnen, JH; Burger, DM; Koks, CH; Meenhorst, PL; Underberg, WJ; van der Heijde, JF	1
Beijnen, JH; Burger, DM; Koks, CH; Meenhorst, PL	1
Ameer, B	1
Boix, V; Esteban, A; González, M; Mora, A; Pérez-Mateo, M; Portilla, J	1
Kagayama, A; Naritomi, Y; Sugiyama, Y; Terashita, S	1
Chen, Y; Cheng, D; Huebert, N; Oulianova, N	1

Reviews

3 review(s) available for acetaminophen and zidovudine

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for acetaminophen and zidovudine

Article	Year
Abnormalities in the metabolism of acetaminophen in patients infected with the human immunodeficiency virus (HIV). Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:2 Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Analgesics, Non-Narcotic; Antiviral Agents; Female; HIV Seropositivity; Humans; Male; Reference Values; Zidovudine	1997

Other Studies

33 other study(ies) available for acetaminophen and zidovudine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Influence of probenecid and paracetamol (acetaminophen) on zidovudine glucuronidation in human liver in vitro. Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:6 Topics: Acetaminophen; Adult; Aged; Glucuronates; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Middle Aged; Probenecid; Zidovudine	1992
The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes. Biochemical pharmacology, 1992, Nov-03, Volume: 44, Issue:9 Topics: Acetaminophen; Animals; Glucuronates; Glucuronosyltransferase; Isoenzymes; Kinetics; Malaria; Male; Mice; Mice, Inbred CBA; Microsomes, Liver; Plasmodium berghei; Rats; Rats, Wistar; Zidovudine	1992
Kinetic and inhibitor studies of acetaminophen and zidovudine glucuronidation in rat liver microsomes. Drug and chemical toxicology, 1992, Volume: 15, Issue:2 Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Drug Interactions; Glucuronates; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Zidovudine	1992
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine. The American journal of medicine, 1992, Volume: 93, Issue:1 Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Zidovudine	1992
The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes. British journal of clinical pharmacology, 1991, Volume: 32, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Chromatography, High Pressure Liquid; Didanosine; Drug Interactions; Female; Glucuronosyltransferase; Humans; Male; Microsomes, Liver; Middle Aged; Salicylates; Sulfanilamide; Sulfanilamides; Zidovudine	1991
Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Acetaminophen; Animals; Body Fluid Compartments; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; Drug Interactions; Humans; Liver; Probenecid; Rats; Rats, Inbred Strains; Zidovudine	1991
Acetaminophen does not impair clearance of zidovudine. Annals of internal medicine, 1991, Jun-01, Volume: 114, Issue:11 Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Analysis of Variance; Drug Interactions; Half-Life; Humans; Metabolic Clearance Rate; Middle Aged; Zidovudine	1991
Guidelines for the care of children and adolescents with HIV infection. Management of the HIV-positive child with fever. The Journal of pediatrics, 1991, Volume: 119, Issue:1 Pt 2 Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Child; Fever; HIV Infections; HIV Seropositivity; Humans; Recurrence; Zidovudine	1991
The effect of acetaminophen on zidovudine metabolism in HIV-infected patients. Journal of acquired immune deficiency syndromes, 1990, Volume: 3, Issue:7 Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; HIV Infections; Humans; Male; Zidovudine	1990
Short-term, combined use of paracetamol and zidovudine does not alter the pharmacokinetics of either drug. The Netherlands journal of medicine, 1994, Volume: 44, Issue:5 Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Drug Interactions; Drug Therapy, Combination; Humans; Male; Zidovudine	1994
Pharmacokinetics of zidovudine and acetaminophen in a patient on chronic acetaminophen therapy. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:3 Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Drug Administration Schedule; Drug Interactions; HIV-1; Homosexuality; Humans; Injections, Intravenous; Male; Time Factors; Zidovudine	1994
Acetaminophen hepatotoxicity augmented by zidovudine. The American journal of medicine, 1993, Volume: 95, Issue:3 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Humans; Rats; Zidovudine	1993
Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5 Topics: Acetaminophen; Animals; Benzodiazepinones; Chromans; Cryopreservation; Diazepam; Diltiazem; Hepatocytes; Humans; Imidazoles; In Vitro Techniques; Indoles; Metabolic Clearance Rate; Predictive Value of Tests; Quinolizines; Rats; Reproducibility of Results; Species Specificity; Tetrazoles; Thiazolidinediones; Time Factors; Troglitazone; Zidovudine	2003
Human oral drugs absorption is correlated to their in vitro uptake by brush border membrane vesicles. International journal of pharmaceutics, 2007, May-04, Volume: 336, Issue:1 Topics: Acetaminophen; Administration, Oral; Animals; Azlocillin; Biological Transport, Active; Cefadroxil; Doxorubicin; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Lamivudine; Mannitol; Osmolar Concentration; Ouabain; Pharmaceutical Preparations; Pharmacokinetics; Phenolsulfonphthalein; Rabbits; Zidovudine	2007