acetaminophen has been researched along with verapamil in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.00) | 18.7374 |
| 1990's | 3 (6.00) | 18.2507 |
| 2000's | 23 (46.00) | 29.6817 |
| 2010's | 21 (42.00) | 24.3611 |
| 2020's | 2 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Ahn, S; Cho, KJ; Choi, Y; Jeong, DY; Kim, YH; Ku, JM; Kwon, S; Lee, JH; Nam, TG; Nam, YJ; Park, JY; Park, K; Yang, J; Yoon, SH | 1 |
| Kolts, BE; Langfitt, M | 1 |
| Elias, MM; Monasterolo, LA; Ochoa, E; Trumper, L | 1 |
| Corcoran, GB; Gurule, MW; Kamendulis, LM; Ray, SD; Yorkin, RD | 1 |
| Dimova, S; Koleva, M; Rangelova, D; Stoythchev, T | 1 |
| Bruhl, M; Rankin, LM | 1 |
| Dimova, S; Koleva, M | 1 |
| Assi, AA | 1 |
| Bodmeier, R; Pearnchob, N; Siepmann, J | 1 |
| Faulkner, MA; Lenz, NJ; Lenz, TL | 1 |
| Bai, SA; Christ, DD; Diamond, S; Grace, JE; Grossman, SJ; He, K; Qian, M; Wong, H; Wright, MR; Yeleswaram, K | 1 |
| Frumin, I; Iancu, TC; Manov, I; Motanis, H | 1 |
| Bashenko, Y; Hirsh, M; Iancu, TC; Manov, I | 1 |
| Kaukonen, AM; Laitinen, L; Marvola, M; Takala, E; Vuorela, H; Vuorela, P | 1 |
| Galkin, A; Heinonen, M; Kreander, K; Laitinen, L; Tammela, P; Vuorela, P; Vuorela, S | 1 |
| Ducros, A | 1 |
| Arvola, V; Franssila, S; Haapala, M; Kauppila, TJ; Kostiainen, R; Kotiaho, T; Luosujärvi, L; Pól, J; Saarela, V | 1 |
| Al-Zoubi, NM; AlKhatib, HS; Obeidat, WM | 1 |
| Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U | 1 |
| Carpini, GD; Ghanem, CI; Luquita, MG; Mottino, AD; Novak, A; Rubio, MC; Ruiz, ML | 1 |
| Farrell, TP; Huatan, H; Missaghi, S; Patel, P; Rajabi-Siahboomi, AR | 1 |
| Burgoon, LD; Johnstone, AF; Lin, BJ; Mack, CM; Shafer, TJ; Turner, JD | 1 |
| Harris, G; Landesmann, B; Mennecozzi, M; Palosaari, T; Whelan, M | 1 |
| Bae, SH; Lee, DH; Lee, YH; Lee, YS; Park, JS; Sung, SH | 1 |
| Chan, LN; Chen, KF; Lin, YS | 1 |
| Badriddinova, LY; Kondratenko, SN; Kovachevich, IV; Polyakov, AV; Repenkova, LG; Savelyeva, MI; Shikh, EV; Svistunov, AA | 1 |
4 review(s) available for acetaminophen and verapamil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Potential interactions between exercise and drug therapy.
Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Aspirin; Digoxin; Doxycycline; Exercise; Humans; Insulin; Pharmacokinetics; Theophylline; Tissue Distribution; Verapamil; Warfarin | 2004 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Liver Diseases; Liver Neoplasms; Verapamil | 2006 |
[Acute and chronic headaches].
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Brain Diseases; Cerebral Angiography; Cerebrovascular Disorders; Chronic Disease; Emergencies; Ergotamine; Female; Follow-Up Studies; Headache; Headache Disorders, Primary; Headache Disorders, Secondary; Hospitalization; Humans; Intracranial Hypertension; Magnetic Resonance Imaging; Middle Aged; Migraine Disorders; Neck; Neurologic Examination; Spinal Puncture; Subarachnoid Hemorrhage; Sumatriptan; Time Factors; Tomography, X-Ray Computed; Ultrasonography, Doppler, Transcranial; Vascular Headaches; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 2006 |
46 other study(ies) available for acetaminophen and verapamil
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration.
Topics: Acetamides; Animals; Axons; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Mice; Molecular Structure; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 2016 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil | 1984 |
Tubular effects of acetaminophen in the isolated perfused rat kidney.
Topics: Acetaminophen; Analysis of Variance; Animals; Dinoprostone; Drug Interactions; In Vitro Techniques; Kidney Tubules; Male; Perfusion; Rats; Rats, Wistar; Verapamil | 1995 |
Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Calcium Channel Blockers; Cell Death; Chlorpromazine; DNA Damage; Liver; Male; Mice; Necrosis; Verapamil | 1993 |
Effect of nifedipine, verapamil, diltiazem and trifluoperazine on acetaminophen toxicity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Calcium Channel Blockers; Calmodulin; Cytochrome P-450 Enzyme System; Diltiazem; Glutathione; Lipid Peroxidation; Male; Mice; Microsomes, Liver; Nifedipine; Survival Rate; Trifluoperazine; Verapamil | 1995 |
Migraine in older patients: a case report and management strategies.
Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyrine; Cheese; Chloral Hydrate; Diagnosis, Differential; Disease Management; Drug Combinations; Female; Food Hypersensitivity; Humans; Methylamines; Migraine Disorders; Verapamil; Wine | 2000 |
Effects of nifedipine, verapamil, diltiazem and trifluoperazine on the antinociceptive activity of acetaminophen.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Calcium Channel Blockers; Cell Fractionation; Diltiazem; Dopamine Antagonists; Drug Synergism; Liver; Male; Mice; Nifedipine; Pain Measurement; Trifluoperazine; Verapamil | 2000 |
The influence of divalent cations on the analgesic effect of opioid and non-opioid drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blood Pressure; Butorphanol; Calcium Channel Blockers; Drug Combinations; Drug Interactions; Drug Synergism; Drug Tolerance; Heart Rate; Injections, Intraperitoneal; Magnesium Sulfate; Memory; Mice; Motor Activity; Motor Skills; Narcotic Antagonists; Nifedipine; Pain; Rats; Verapamil | 2001 |
Pharmaceutical applications of shellac: moisture-protective and taste-masking coatings and extended-release matrix tablets.
Topics: Acetaminophen; Aspirin; Delayed-Action Preparations; Drug Stability; Humans; Hypromellose Derivatives; Methylcellulose; Resins, Plant; Solubility; Taste; Theophylline; Verapamil; Wettability | 2003 |
The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Non-Narcotic; Animals; Blotting, Western; Bronchodilator Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Models, Biological; Pan troglodytes; Pharmaceutical Preparations; Pharmacokinetics; Propranolol; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Verapamil | 2004 |
Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells.
Topics: Acetaminophen; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Gene Expression Regulation, Neoplastic; Humans; Oxidative Stress; Verapamil | 2006 |
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2).
Topics: Absorption; Acetaminophen; Anthraquinones; Beverages; Caco-2 Cells; Carbon Radioisotopes; Cathartics; Cell Membrane Permeability; Digoxin; Furosemide; Humans; Ketoprofen; Mannitol; Plant Leaves; Propranolol; Senna Extract; Sennosides; Verapamil | 2007 |
In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions.
Topics: Acetaminophen; Anthocyanins; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fluorenes; Fruit; Humans; Hydrolyzable Tannins; Ketoprofen; Metoprolol; Mutagenicity Tests; Plant Extracts; Rosaceae; Salmonella typhimurium; Spectrometry, Mass, Electrospray Ionization; Verapamil | 2006 |
Desorption and ionization mechanisms in desorption atmospheric pressure photoionization.
Topics: Acetaminophen; Atmospheric Pressure; Ions; Mass Spectrometry; Microarray Analysis; N-Methyl-3,4-methylenedioxyamphetamine; Organic Chemicals; Photochemical Processes; Solvents; Testosterone; Verapamil | 2008 |
Evaluation of hydrophilic matrix tablets based on Carbopol(®) 971P and low-viscosity sodium alginate for pH-independent controlled drug release.
Topics: Acetaminophen; Acrylates; Alginates; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems; Glucuronic Acid; Hexuronic Acids; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Microscopy, Electron, Scanning; Particle Size; Salicylic Acid; Tablets; Verapamil; Viscosity | 2011 |
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.
Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme System; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Hepatocytes; Humans; Isoenzymes; Liver Neoplasms; Oxidative Stress; Pharmaceutical Preparations; Verapamil | 2012 |
Acetaminophen inhibits intestinal p-glycoprotein transport activity.
Topics: Acetaminophen; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Line, Tumor; Cyclosporins; Digoxin; Enterocytes; Hep G2 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Permeability; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2013 |
Investigation of critical core formulation and process parameters for osmotic pump oral drug delivery.
Topics: Acetaminophen; Administration, Oral; Chemistry, Pharmaceutical; Dosage Forms; Drug Delivery Systems; Membrane Transport Proteins; Osmosis; Polyethylene Glycols; Polymers; Solubility; Tablets; Theophylline; Verapamil | 2014 |
Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.
Topics: Acetaminophen; Action Potentials; Animals; Cells, Cultured; Cerebral Cortex; Data Interpretation, Statistical; Fluoxetine; GABA Antagonists; Kainic Acid; Microelectrodes; Muscimol; Nerve Net; Neurons; Nicotine; Pesticides; Principal Component Analysis; Rats; Rats, Long-Evans; Verapamil | 2014 |
Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Calcium; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chlorpromazine; Diclofenac; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Omeprazole; Primary Cell Culture; Sex Characteristics; Verapamil | 2015 |
The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity.
Topics: Acetaminophen; Animals; Antihypertensive Agents; Autophagy; Cells, Cultured; Cytoprotection; HEK293 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Mice; NF-E2-Related Factor 2; Oxidative Stress; Proteolysis; Reactive Oxygen Species; Verapamil | 2017 |
PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery.
Topics: Acetaminophen; Administration, Oral; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Gastric Bypass; Gastrointestinal Absorption; Hepatobiliary Elimination; Humans; Intestinal Elimination; Metabolic Clearance Rate; Midazolam; Models, Biological; Obesity, Morbid; Postoperative Period; Triazoles; Verapamil | 2020 |
Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions.
Topics: Acetaminophen; Furosemide; Humans; Hypokinesia; Pharmaceutical Preparations; Propranolol; Space Flight; Verapamil | 2021 |