Compounds > acetaminophen

acetaminophen and troleandomycin

acetaminophen has been researched along with troleandomycin in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's3 (27.27)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Bement, WJ; Guzelian, PS; Lambrecht, LK; McCaffrey, J; Park, SS; Schenkman, JB; Sinclair, JF; Sinclair, PR; Smith, EL; Wood, SG1
Kostrubsky, VE; Lewis, LD; Sinclair, JF; Sinclair, PR; Wood, SG; Wrighton, SA1
Bement, WJ; Jeffery, EH; Kostrubsky, VE; Sinclair, JF; Sinclair, PR; Szakacs, JG; Wood, SG; Wrighton, SA1
Bement, WJ; Jeffery, EH; Kostrubsky, VE; Sinclair, JF; Sinclair, PR; Szakacs, JG; Wood, SG; Wright, D; Wrighton, SA1
Bement, J; Chatfield, K; DiPetrillo, K; Jeffery, E; Kostrubsky, V; Sinclair, J; Sinclair, P; Wood, S; Wrighton, S1
Allard, JL; Court, MH; Duan, SX; Gonzalez, FJ; Gorman, N; Greenblatt, DJ; Hao, Q; Hunt, JA; Jeffery, EH; Kostrubsky, V; Sinclair, JF; Sinclair, PR; Szakacs, JG; von Moltke, LL; Walton-Strong, BW; Wolf, KK; Wood, SG; Wrighton, SA1

Other Studies

11 other study(ies) available for acetaminophen and troleandomycin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes.
    Archives of biochemistry and biophysics, 1991, Feb-01, Volume: 284, Issue:2

    Topics: Acetaminophen; Animals; Cells, Cultured; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Ethanol; Hydroxylation; Liver; Male; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin

1991
Effect of Taxol on cytochrome P450 3A and acetaminophen toxicity in cultured rat hepatocytes: comparison to dexamethasone.
    Toxicology and applied pharmacology, 1997, Volume: 142, Issue:1

    Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Oxidoreductases, N-Demethylating; Paclitaxel; Rats; Rats, Inbred F344; RNA, Messenger; Troleandomycin

1997
Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity.
    Toxicology and applied pharmacology, 1997, Volume: 143, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Central Nervous System Depressants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Ethanol; Liver; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred F344; Troleandomycin

1997
Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.
    Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Ethanol; Liver Diseases; Male; Oxidoreductases, N-Demethylating; Pentanols; Protective Agents; Rats; Rats, Inbred F344; Troleandomycin

2000
Effect of caffeine on acetaminophen hepatotoxicity in cultured hepatocytes treated with ethanol and isopentanol.
    Toxicology and applied pharmacology, 2002, Dec-01, Volume: 185, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Drug Synergism; Enzyme Inhibitors; Ethanol; Hepatocytes; Oxidoreductases, N-Demethylating; Pentanols; Rats; Troleandomycin

2002
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7

    Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Ethanol; Glucuronides; Glutathione; Hydroxylation; Imines; Liver; Liver Diseases; Male; Mice; Mice, Knockout; Pentanols; Severity of Illness Index; Testosterone; Troleandomycin

2007