acetaminophen has been researched along with theophylline in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (23.40) | 18.7374 |
| 1990's | 24 (17.02) | 18.2507 |
| 2000's | 43 (30.50) | 29.6817 |
| 2010's | 35 (24.82) | 24.3611 |
| 2020's | 6 (4.26) | 2.80 |
| Authors | Studies |
|---|---|
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Majumdar, S; Sloan, KB | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Devarajan-Ketha, H; Sloan, KB | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P | 1 |
| Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A | 1 |
| Dusci, LJ; Hackett, LP | 1 |
| Philipp-Dormston, WK | 1 |
| Hall, WJ; O'Donoghue, JP; O'Regan, MG; Penny, WJ | 1 |
| Currin, MR | 1 |
| Alberola, S; Jeanjean, B; Sabon, F; Terol, A | 1 |
| Johnson, GF; Kiser, EJ; Witte, DL | 1 |
| Walley, T | 1 |
| Breäs, R; Crommelin, DJ; Poelma, FG; Tukker, JJ | 1 |
| Kalhorn, TF; Lee, CA; Nelson, SD; Slattery, JT | 1 |
| Nakanishi, S; Okuno, H | 1 |
| Breäs, R; Poelma, FG; Tukker, JJ | 1 |
| Gaitonde, CD; Pathak, PV | 1 |
| de Vries, MH; Glerum, JH; Kadir, F; Rademaker, CM; van Dijk, A | 1 |
| Arama, E; Michaud, P; Rodriguez, F; Rouffiac, R | 1 |
| Baciewicz, AM | 1 |
| Ford, D; Meatherall, R | 1 |
| Bhargava, VO; Emodi, S; Hirate, J | 1 |
| Budd, RD; Mathis, DF | 1 |
| Osterloh, J; Yu, S | 1 |
| Opheim, KE; Raisys, VA | 1 |
| Jatlow, P | 1 |
| Appel, GB; Franki, N; Gouaux, J; Hays, RM; Lozada, ES | 1 |
| Knepil, J | 1 |
| Chow, YP; Repta, AJ | 1 |
| Guillory, JK; Hwang, SC; Lach, JL | 1 |
| Stange, G | 1 |
| Ganote, DP; Lücker, PW | 1 |
| Greene, W | 1 |
| Frawley, VL; Ou, CN | 1 |
| Lauterburg, BH; Mitchell, JR | 1 |
| Luczynska, C; Wilson, K | 1 |
| D'Arcy, PF | 1 |
| Bigelow, SW; Lazarte, RA; Levitt, RC; Nebert, DW | 1 |
| Putnam, RS; Quattrone, AJ | 1 |
| Holmén, A; Kinberger, B | 1 |
| Smith, FA | 1 |
| Crome, P; Helliwell, M; Raper, S; Vale, A; Widdop, B | 1 |
| Flahaut, J; Mally, F; Rivet, J | 1 |
| Chyka, PA; Holley, JE; Mandrell, TD; Sugathan, P | 1 |
| Chen, A; Lunte, CE | 1 |
| Abdel-Meguid, EM; Farag, MM | 1 |
| Danyoshi, C; Hirakawa, Y; Murata, K; Nagata, M; Narisawa, S; Noda, K; Yoshino, H | 1 |
| Häglund, BO; Sundelöf, LO; Upadrashta, SM | 1 |
| Kissinger, PT; Linhares, MC | 1 |
| Fortier, G; Gayet, JC | 1 |
| Lee, CA; Lillibridge, JH; Nelson, SD; Slattery, JT | 1 |
| Casley, WL; Girard, M; Larocque, L; Menzies, JA; Moon, TW; Mousseau, N; Whitehouse, LW | 1 |
| Agasøster, T | 1 |
| Angus, PW; Froomes, PR; Morgan, DJ; Smallwood, RA | 1 |
| Pakes, GE | 1 |
| Ikegami, K; Ishibashi, T; Kobayashi, M; Kubo, H; Mizobe, M; Yoshino, H | 1 |
| Kunkel, A; Wätzig, H | 2 |
| Dabek-Zlotorzynska, E; Lai, EP | 1 |
| Dawson, AH; Whyte, IM | 2 |
| Cartilier, L; Chebli, C | 1 |
| Choi, H; Lee, J; Park, TG | 1 |
| Bebawy, LI; El-Kousy, NM | 1 |
| Aiedeh, K; Taha, MO | 1 |
| Bodmeier, R; Peppas, NA; Siepmann, J; Streubel, A | 1 |
| Boobis, AR; Edwards, RJ; Murray, BP; Murray, S; Odupitan, AO | 1 |
| McGuigan, ME | 1 |
| Bi, K; Dai, R; Luo, X; Wang, X | 1 |
| Hanke, R; Kaiser, P; Kress, M; Meissner, D; Wood, WG | 1 |
| Ikegami, K; Kobayashi, M; Osawa, T; Tagawa, K | 1 |
| Bodmeier, R; Pearnchob, N; Siepmann, J | 1 |
| Law, D; Qiu, Y; Schmitt, EA; Zhang, GG | 1 |
| Ju, H; Shi, X; Yuan, Z; Zhang, D | 1 |
| De Los Santos, AR; Di Girolamo, G; González, CD; Sánchez, AJ | 1 |
| Faulkner, MA; Lenz, NJ; Lenz, TL | 1 |
| Yokoyama, T | 1 |
| Bai, SA; Christ, DD; Diamond, S; Grace, JE; Grossman, SJ; He, K; Qian, M; Wong, H; Wright, MR; Yeleswaram, K | 1 |
| Codipilly, CN; Wapnir, RA | 1 |
| Albertini, B; Cavallari, C; Giovannelli, L; Passerini, N; Rodriguez, L | 1 |
| Huang, X; Xu, M | 1 |
| Kleinebudde, P; Thommes, M | 1 |
| Fujisawa, M; Hirose, Y; Hori, Y; Shimada, K; Yoshioka, T | 1 |
| Barr, G; Dallman, C; Dong, W; Feeder, N; Gilmore, C; Terry, S | 1 |
| Balwinski, KM; Mitchell, SA | 1 |
| Boskovic, M; Injac, R; Karljikovic-Rajic, K; Prijatelj, M; Srdjenovic, B; Strukelj, B | 1 |
| Budha, NR; Christensen, ML; Mehrotra, N; Meibohm, B; Zhang, Y | 1 |
| Carlin, B; Leclercq, B; Muschert, S; Siepmann, F; Siepmann, J | 1 |
| Kataoka, M; Kokubo, H; Masaoka, Y; Ogura, R; Sakuma, S; Tanno, FK; Yamashita, S | 1 |
| Antonios, D; Gautier, JC; Lacour, S; Pallardy, M | 1 |
| Chan, TY; Cheng, CA; Gomersall, CD; Woo, J | 1 |
| Ortiz, MI | 1 |
| Bithell, EG; Eddleston, MD; Jones, W | 1 |
| Mao, S; Sun, W; Zhang, T | 1 |
| Ihalainen, P; Kronberg, L; Määttänen, A; Meierjohann, A; Peltonen, J; Sandler, N; Viitala, T | 1 |
| Flanagan, DR; Lee, HG; Zhang, GG | 1 |
| Ghanam, D; Kleinebudde, P | 1 |
| Chou, KC; Li, J; Wang, JF; Wei, DQ; Yu, ZT | 1 |
| Baumgartner, E; Fiala, A; Furgler, G; Paal, P | 1 |
| Bithell, EG; Day, GM; Eddleston, MD; Hejczyk, KE; Jones, W | 1 |
| Li, L; Mao, S; Ni, R; Shao, Y; Wang, L; Zhang, T | 1 |
| Farrell, TP; Huatan, H; Missaghi, S; Patel, P; Rajabi-Siahboomi, AR | 1 |
| Sklar, GE; Tan, DS | 1 |
| Hassani, E; Hatami, S; Javaheri, N; Mahoori, A; Noroozinia, H | 1 |
| Inoue, Y | 1 |
| Ehlers, H; Svanbäck, S; Yliruusi, J | 1 |
| Abdelaleem, EA; Ali, NW; Hassan, ES; Naguib, IA | 1 |
| Coboeken, K; Ince, I; Meyer, M; Schmidt, S; Schnizler, K; Somani, AA; Thelen, K; Trame, MN; Willmann, S; Zheng, S | 1 |
| De Beer, T; De Geest, BG; Kasmi, S; Remon, JP; Van Bockstal, PJ; Van Renterghem, J; Verstraete, G; Vervaet, C | 1 |
| González-de la Parra, M; Murguía-Cánovas, G; Ortiz, MI; Silva, R; Vargas-López, LC | 1 |
| Mukaida, M; Sato, H; Sugano, K; Terada, K | 1 |
| Bonner, JJ; Jamei, M; Johnson, TN; Tucker, GT; Turner, DB | 1 |
| Bandari, S; Kallakunta, VR; Kim, DW; Patil, H; Repka, MA; Sarabu, S; Tiwari, R; Upadhye, S; Vladyka, RS; Ye, X | 1 |
| Al-Sharabi, M; Bawuah, P; Gane, P; Karttunen, AP; Ketolainen, J; Markl, D; Mudley, T; Peiponen, KE; Rades, T; Ridgway, C; Zeitler, JA | 1 |
| Bois, FY; Chiu, WA; Gao, W; Hsieh, NH; Reisfeld, B | 1 |
| Cao, Y; Guan, Q; Guo, H; Wang, M; Wu, N; Xue, R; Yang, W; Zhao, X | 1 |
| Burckart, GJ; Dallmann, A; Liu, XI; van den Anker, JN | 1 |
15 review(s) available for acetaminophen and theophylline
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Pharmacology of the neonate.
Topics: Acetaminophen; Adsorption; Aminoglycosides; Barbiturates; Benzodiazepines; Benzothiadiazines; Biological Availability; Body Composition; Cephalosporins; Digoxin; Diuretics; Female; Humans; Infant, Newborn; Injections, Intravenous; Maternal-Fetal Exchange; Meperidine; Penicillins; Pharmaceutical Preparations; Placenta; Pregnancy; Protein Binding; Salicylates; Sodium Chloride Symporter Inhibitors; Theophylline; Tissue Distribution | 1979 |
Oral contraceptive drug interactions.
Topics: Acetaminophen; Anti-Anxiety Agents; Anti-Bacterial Agents; Benzodiazepines; Contraceptives, Oral; Drug Interactions; Female; Glucocorticoids; Humans; Kinetics; Male; Pregnancy; Rifampin; Theophylline | 1985 |
Therapeutic drug monitoring in pediatric acute drug intoxications.
Topics: Acetaminophen; Alcoholic Intoxication; Antidepressive Agents, Tricyclic; Child; Humans; Iron; Kinetics; Monitoring, Physiologic; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Poisoning; Salicylates; Salicylic Acid; Theophylline | 1985 |
Drug interactions involving cimetidine--mechanisms, documentation, implications.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12 | 1984 |
The clinical significance of the effects of cigarette smoking on drug disposition.
Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin | 1983 |
Tobacco smoking and drugs: a clinically important interaction?
Topics: Acetaminophen; Animals; Dextropropoxyphene; Drug Interactions; Enzyme Induction; Glutethimide; Humans; Insulin; Lidocaine; Microsomes, Liver; Mixed Function Oxygenases; Pentazocine; Pharmaceutical Preparations; Phenacetin; Phenylbutazone; Propranolol; Smoking; Theophylline | 1984 |
Therapeutic drug monitoring of theophylline, salicylates, and acetaminophen.
Topics: Acetaminophen; Humans; Salicylates; Theophylline | 1981 |
Therapeutic drug monitoring in drug overdose.
Topics: Acetaminophen; Anticonvulsants; Digoxin; Drug Monitoring; Drug Overdose; Ethanol; Ethylene Glycol; Humans; Iron; Lithium; Methanol; Paraquat; Prognosis; Salicylates; Theophylline | 1999 |
Poisoning potpourri.
Topics: Acetaminophen; Age Factors; Alcohol Drinking; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child; Drug Overdose; Electrocardiography; Ethanol; Hemodialysis Solutions; Humans; Hydrocarbons; Methanol; Poisoning; Theophylline | 2001 |
Therapeutic drug monitoring in drug overdose.
Topics: Acetaminophen; Digoxin; Drug Monitoring; Drug Overdose; Half-Life; Humans; Metabolic Clearance Rate; Pharmacokinetics; Prognosis; Theophylline | 2001 |
Phase transformation considerations during process development and manufacture of solid oral dosage forms.
Topics: Acetaminophen; Administration, Oral; Aspirin; Capsules; Carbamazepine; Chemistry Techniques, Analytical; Crystallization; Drug Compounding; Drug Stability; Excipients; Freeze Drying; Humans; Particle Size; Pharmaceutical Preparations; Phase Transition; Ritonavir; Solvents; Tablets; Technology, Pharmaceutical; Theophylline; Thermodynamics; Thiamine; Transition Temperature; Water | 2004 |
Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Trials as Topic; Drug Combinations; Drug Therapy, Combination; Dysmenorrhea; Female; Humans; Propanolamines; Theophylline | 2004 |
Potential interactions between exercise and drug therapy.
Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Aspirin; Digoxin; Doxycycline; Exercise; Humans; Insulin; Pharmacokinetics; Theophylline; Tissue Distribution; Verapamil; Warfarin | 2004 |
[Blood concentration useful in the diagnosis and treatment of poisoning].
Topics: Acetaminophen; Aspirin; Barbiturates; Digoxin; Drug Monitoring; Humans; Inorganic Chemicals; Lithium; Organic Chemicals; Pesticides; Poisoning; Theophylline | 2014 |
3 trial(s) available for acetaminophen and theophylline
| Article | Year |
|---|---|
Comparative effects of oxygen supplementation on theophylline and acetaminophen clearance in human cirrhosis.
Topics: Acetaminophen; Adult; Female; Humans; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Oxygen; Theophylline | 1999 |
Theophylline versus acetaminophen in the treatment of post-dural puncture headache (PDPH).
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthesia, Spinal; Female; Humans; Male; Middle Aged; Pain Measurement; Phosphodiesterase Inhibitors; Post-Dural Puncture Headache; Single-Blind Method; Spinal Puncture; Theophylline; Time Factors; Treatment Outcome | 2013 |
Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Combinations; Dysmenorrhea; Female; Humans; Mexico; Naproxen; Pain Measurement; Propanolamines; Pyrilamine; Tablets; Theophylline; Treatment Outcome; Young Adult | 2016 |
123 other study(ies) available for acetaminophen and theophylline
| Article | Year |
|---|---|
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs.
Topics: Administration, Cutaneous; Drug Delivery Systems; Hydrogen-Ion Concentration; Hydrolysis; Imides; Molecular Structure; Phenols; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 2006 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
N,N'-Dialkylaminoalkylcarbonyl (DAAC) prodrugs and aminoalkylcarbonyl (AAC) prodrugs of 4-hydroxyacetanilide and naltrexone with improved skin permeation properties.
Topics: Acetanilides; Animals; Cells, Cultured; Mice; Molecular Structure; Naltrexone; Prodrugs; Skin | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines | 2021 |
High performance liquid chromatography in clinical toxicology. I. General drugs.
Topics: Acetaminophen; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indomethacin; Pharmaceutical Preparations; Theophylline; Thiazines; Toxicology | 1978 |
Evidence for the involvement of adenosine 3',5'-cyclic monophosphate in fever genesis.
Topics: Acetaminophen; Animals; Brain; Cyclic AMP; Female; Fever; Hypothalamus; Injections, Intraventricular; Male; Prostaglandins E; Prostaglandins F; Theophylline | 1976 |
Endogenous prostaglandins, adenosine 3':5'-monophosphate and sodium transport across isolated frog skin.
Topics: Acetaminophen; Animals; Arachidonic Acids; Biological Transport; Cyclic AMP; Female; In Vitro Techniques; Indomethacin; Male; Prostaglandins E; Rana temporaria; Skin; Sodium; Theophylline | 1976 |
[Contribution to the study of paracetamol-theophylline and paracetamol-caffeine associations (author's transl)].
Topics: Acetaminophen; Caffeine; Chemical Phenomena; Chemistry; Chemistry, Physical; Theophylline | 1979 |
Serum uric acid determined by reversed-phase liquid chromatography with spectrophotometric detection.
Topics: Acetaminophen; Allopurinol; Chromatography, Liquid; Drug Interactions; Humans; Methods; Oxypurinol; Salicylates; Spectrophotometry, Ultraviolet; Theophylline; Urate Oxidase; Uric Acid | 1978 |
Drug interactions with OTCs.
Topics: Acetaminophen; Antacids; Aspirin; Drug Interactions; Histamine H1 Antagonists; Humans; Ibuprofen; Nonprescription Drugs; Sympathomimetics; Theophylline | 1991 |
Intestinal absorption of drugs. The influence of mixed micelles on on the disappearance kinetics of drugs from the small intestine of the rat.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Dantrolene; Griseofulvin; Intestinal Absorption; Intestine, Small; Ketoconazole; Kinetics; Lysophosphatidylcholines; Micelles; Models, Biological; Mucus; Rats; Solubility; Swine; Taurocholic Acid; Theophylline | 1991 |
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1990 |
Comparison of inhibitory effects of new quinolones on drug metabolizing activity in the liver.
Topics: Acetaminophen; Animals; Anti-Infective Agents; Enoxacin; Glutathione; Liver; Liver Function Tests; Male; Microsomes, Liver; Mixed Function Oxygenases; Norfloxacin; Ofloxacin; Rats; Theophylline | 1990 |
Intestinal absorption of drugs. III. The influence of taurocholate on the disappearance kinetics of hydrophilic and lipophilic drugs from the small intestine of the rat.
Topics: Acetaminophen; Animals; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Griseofulvin; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Ketoconazole; Models, Biological; Perfusion; Pharmacokinetics; Rats; Solubility; Taurocholic Acid; Theophylline | 1990 |
Estimation of the analgesic muscle relaxants chlorzoxazone and diazepam in human plasma by reversed-phase liquid chromatography.
Topics: Acetaminophen; Analgesics; Benzoxazoles; Chlorzoxazone; Chromatography; Diazepam; Humans; Muscle Relaxants, Central; Oxyphenbutazone; Theophylline | 1990 |
A ready-to-use activated charcoal mixture. Adsorption studies in vitro and in dogs: its influence on the intestinal secretion of theophylline in a rat model.
Topics: Acetaminophen; Adsorption; Animals; Charcoal; Dogs; Rats; Theophylline | 1989 |
[Bioavailability of prolonged-liberation tablets of theophylline and paracetamol formulated in pulp from the fruit of baobab (Adansonia digitata L.)].
Topics: Acetaminophen; Biological Availability; Delayed-Action Preparations; Humans; Plants; Theophylline | 1989 |
Isocratic liquid chromatographic determination of theophylline, acetaminophen, chloramphenicol, caffeine, anticonvulsants, and barbiturates in serum.
Topics: Acetaminophen; Anticonvulsants; Barbiturates; Caffeine; Chloramphenicol; Chromatography, High Pressure Liquid; Humans; Theophylline | 1988 |
Quantitation of acetaminophen and its metabolites in rat plasma after a toxic dose.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Injections, Intravenous; Rats; Spectrophotometry, Ultraviolet; Theobromine; Theophylline | 1988 |
Extraction of acetaminophen and theophylline from post-mortem tissues and urine for high-performance liquid chromatographic analysis.
Topics: Acetaminophen; Bile; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Spectrophotometry, Ultraviolet; Theophylline | 1988 |
Simultaneous ion-pair and partition liquid chromatography of acetaminophen, theophylline and salicylate with application to 500 toxicologic specimens.
Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Humans; Salicylates; Spectrophotometry, Ultraviolet; Theophylline | 1988 |
Ultraviolet spectrophotometric analysis of barbiturates: evaluation of potential interferences.
Topics: Acetaminophen; Barbiturates; Chlorothiazide; Chlorpropamide; Dicumarol; Humans; Methods; Nicotinic Acids; Oxyphenbutazone; Phenacetin; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Salicylates; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Sulfinpyrazone; Sulfisoxazole; Theobromine; Theophylline; Warfarin | 1973 |
Studies of the mode of action of the sulfonylureas and phenylacetamides in enhancing the effect of vasopressin.
Topics: Acetaminophen; Adenylyl Cyclase Inhibitors; Animals; Bufo marinus; Chlorpropamide; Cyclic AMP; Drug Synergism; In Vitro Techniques; Osmosis; Phenacetin; Phosphoric Monoester Hydrolases; Prostaglandins; Stimulation, Chemical; Sulfonylurea Compounds; Theophylline; Tritium; Urinary Bladder; Vasopressins; Water | 1972 |
A sensitive, specific method for measuring N-acetyl-p-aminophenol (paracetamol) in blood.
Topics: Acetaminophen; Amobarbital; Chlordiazepoxide; Evaluation Studies as Topic; Humans; Indicators and Reagents; Methods; Microchemistry; Pentobarbital; Phenobarbital; Salicylates; Spectrophotometry, Ultraviolet; Theophylline | 1974 |
Complexation of acetaminophen with methyl xanthines.
Topics: Acetaminophen; Caffeine; Calorimetry; Chemistry, Pharmaceutical; Kinetics; Magnetic Resonance Spectroscopy; Solubility; Spectrophotometry; Spectrum Analysis; Theobromine; Theophylline | 1972 |
Interactions between pharmaceutical compounds by thermal methods.
Topics: Acetaminophen; Aspirin; Atropine; Bile Acids and Salts; Caffeine; Drug Compounding; Drug Incompatibility; Drug Stability; Methods; Phenacetin; Phenobarbital; Phenytoin; Quinine; Temperature; Theophylline; Thermodynamics; Time Factors; Vitamin K | 1969 |
[On the therapy of impairment and loss of hearing].
Topics: Acetaminophen; Bicarbonates; Deafness; Hearing Disorders; Hearing Tests; Humans; Nicotinic Acids; Theophylline; Turpentine; Vitamin A; Vitamin B Complex; Vitamin E | 1967 |
A new mathematical approach to describe transmural gastric potential difference changes (great moments in pharmacodynamics).
Topics: Acetaminophen; Aspirin; Ethanol; Gastric Mucosa; Histamine H2 Antagonists; Humans; Kinetics; Membrane Potentials; Models, Biological; Theophylline | 1982 |
Theophylline, dyphylline, caffeine, acetaminophen, salicylate, acetylsalicylate, procainamide, and N-acetylprocainamide determined in serum with a single liquid-chromatographic assay.
Topics: Acecainide; Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Pharmaceutical Preparations; Procainamide; Salicylates; Salicylic Acid; Theophylline | 1982 |
Regulation of hepatic glutathione turnover in rats in vivo and evidence for kinetic homogeneity of the hepatic glutathione pool.
Topics: Acetaminophen; Animals; Bucladesine; Cell Compartmentation; Fasting; Gluconeogenesis; Glutathione; Kinetics; Liver; Rats; Theophylline | 1981 |
Effects of cimetidine on theophylline, acetaminophen, and zoxazolamine toxicity in the intact mouse.
Topics: Acetaminophen; Animals; Cimetidine; Cytochrome P-450 Enzyme System; Female; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Theophylline; Zoxazolamine | 1984 |
A single liquid-chromatographic procedure for therapeutic monitoring of theophylline, acetaminophen, or ethosuximide.
Topics: Acetaminophen; Blood Chemical Analysis; Buffers; Chromatography, High Pressure Liquid; Ethosuximide; Humans; Immunoenzyme Techniques; Theophylline | 1981 |
Simultaneous determination of acetaminophen, theophylline and salicylate in serum by high-performance liquid chromatography.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Salicylates; Theophylline | 1982 |
Experience with activated carbon-bead haemoperfusion columns in the treatment of severe drug intoxication. A preliminary report.
Topics: Acetaminophen; Adolescent; Adult; Aged; Charcoal; Female; Glutethimide; Hemoperfusion; Humans; Phenobarbital; Poisoning; Theophylline | 1982 |
[Contribution to the study of benzoic acid-theophylline and benzoic acid-paracetamol (author's transl)].
Topics: Acetaminophen; Benzoates; Benzoic Acid; Chemistry, Pharmaceutical; Drug Combinations; Theophylline | 1981 |
Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy.
Topics: Acetaminophen; Animals; Charcoal; Digoxin; Disease Models, Animal; Drug Administration Schedule; Female; Half-Life; Linear Models; Metabolic Clearance Rate; Pharmacokinetics; Poisoning; Poisons; Prospective Studies; Random Allocation; Swine; Theophylline; Valproic Acid | 1995 |
Microdialysis sampling coupled on-line to fast microbore liquid chromatography.
Topics: Acetaminophen; Animals; Caffeine; Chromatography, High Pressure Liquid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline | 1995 |
Hepatic glutathione and lipid peroxidation in rats treated with theophylline. Effect of dose and combination with caffeine and acetaminophen.
Topics: Acetaminophen; Animals; Caffeine; Dose-Response Relationship, Drug; Glutathione; Lipid Peroxidation; Liver; Male; Rats; Theophylline | 1994 |
An organic acid-induced sigmoidal release system for oral controlled-release preparations.
Topics: Acetaminophen; Acrylic Resins; Animals; Colon, Sigmoid; Delayed-Action Preparations; Dogs; Male; Permeability; Solubility; Succinates; Succinic Acid; Theophylline | 1994 |
Diffusion and concentration profiles of drugs in gels.
Topics: Acetaminophen; Chlorpheniramine; Diffusion; Gels; Humans; Ibuprofen; Indomethacin; Pharmacokinetics; Temperature; Theophylline | 1993 |
Pharmacokinetic monitoring in subcutaneous tissue using in vivo capillary ultrafiltration probes.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Half-Life; Rats; Skin; Spectrophotometry, Ultraviolet; Theophylline; Tissue Distribution; Ultracentrifugation | 1993 |
Drug release from new bioartificial hydrogel.
Topics: Acetaminophen; Albumins; Animals; Cattle; Delayed-Action Preparations; Drug Carriers; Hydrocortisone; Hydrogel, Polyethylene Glycol Dimethacrylate; Kinetics; Mathematics; Polyethylene Glycols; Theophylline; Water | 1995 |
Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Glutathione; Imines; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Theophylline | 1996 |
Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.
Topics: Acetaminophen; Animals; Caffeine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; Female; Gene Expression Regulation, Enzymologic; Immunoblotting; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oligonucleotide Probes; Phenotype; RNA, Messenger; Sex Factors; Theophylline | 1997 |
Aqueous two-phase partitioning sample preparation prior to liquid chromatography of hydrophilic drugs in blood.
Topics: Acetaminophen; Animals; Blood Proteins; Buffers; Cattle; Chemical Precipitation; Chromatography, High Pressure Liquid; Contrast Media; Dialysis; Humans; Iohexol; Phosphates; Polyethylene Glycols; Quality Control; Sensitivity and Specificity; Theophylline | 1998 |
'Pharmaceutical ambrosia' ups compliance by 28%.
Topics: Acetaminophen; Ambulatory Care; California; Cooking; Hospital Bed Capacity, 500 and over; Humans; Hydroxides; Patient Compliance; Pharmaceutical Preparations; Potassium Chloride; Theophylline | 1979 |
Evaluation of colonic absorbability of drugs in dogs using a novel colon-targeted delivery capsule (CTDC).
Topics: Absorption; Acetaminophen; Administration, Oral; Administration, Rectal; Animals; Capsules; Chromatography, High Pressure Liquid; Colon; Dogs; Fasting; Gastric Emptying; In Vitro Techniques; Male; Organ Specificity; Phenylpropanolamine; Sulfasalazine; Theophylline; Time Factors | 1999 |
Pharmacokinetic investigations with direct injection of plasma samples: possible savings using capillary electrophoresis (CE).
Topics: Acetaminophen; Blood Proteins; Drug Monitoring; Electrophoresis, Capillary; Humans; Reproducibility of Results; Salicylic Acid; Sulfamethoxazole; Theophylline; Tolbutamide; Trimethoprim | 1999 |
Separation of theophylline, caffeine and related drugs by normal-phase capillary electrochromatography.
Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Electric Conductivity; Electrophoresis, Capillary; Hydrochlorothiazide; Molecular Structure; Niacin; Phenylbutazone; Theobromine; Theophylline | 1999 |
Micellar electrokinetic capillary chromatography as a powerful tool for pharmacological investigations without sample pretreatment: a precise technique providing cost advantages and limits of detection to the low nanomolar range.
Topics: Acetaminophen; Chromatography, Micellar Electrokinetic Capillary; Costs and Cost Analysis; Humans; Reproducibility of Results; Salicylic Acid; Sulfamethoxazole; Theophylline; Time Factors; Tolbutamide; Trimethoprim | 1999 |
Effect of some physical parameters on the sustained drug-release properties of substituted amylose matrices.
Topics: Acetaminophen; Algorithms; Amylose; Analgesics, Non-Narcotic; Anti-Allergic Agents; Bronchodilator Agents; Chemical Phenomena; Chemistry, Physical; Chlorpheniramine; Delayed-Action Preparations; Drug Compounding; Excipients; Pressure; Solubility; Theophylline | 2000 |
Effect of formulation and processing variables on the characteristics of microspheres for water-soluble drugs prepared by w/o/o double emulsion solvent diffusion method.
Topics: Acetaminophen; Acrylic Resins; Corn Oil; Diffusion; Dose-Response Relationship, Drug; Drug Compounding; Emulsions; Methylene Chloride; Microspheres; Polymethacrylic Acids; Propranolol; Solvents; Surface-Active Agents; Tacrine; Temperature; Theophylline; Water | 2000 |
Simultaneous determination of some multicomponent dosage forms by quantitative thin layer chromatography densitometric method.
Topics: Acetaminophen; Caffeine; Chlorzoxazone; Chromatography, Thin Layer; Densitometry; Diflunisal; Dosage Forms; Naproxen; Pharmaceutical Preparations; Solvents; Theophylline | 1999 |
Synthesis of iron-crosslinked hydroxamated alginic acid and its in vitro evaluation as a potential matrix material for oral sustained-release beads.
Topics: Acetaminophen; Alginates; Chlorpheniramine; Cross-Linking Reagents; Delayed-Action Preparations; Drug Carriers; Hydroxamic Acids; Spectrophotometry, Infrared; Theophylline | 2000 |
Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design.
Topics: Acetaminophen; Biological Transport; Chemistry, Pharmaceutical; Drug Delivery Systems; Methylcellulose; Tablets; Theophylline | 2000 |
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines | 2001 |
[Application of statistical simulation spectrophotometry to the determination of four medicaments in feibaosanxiao tablets].
Topics: Acetaminophen; Caffeine; Drug Combinations; Monte Carlo Method; Phenytoin; Spectrophotometry; Tablets; Theophylline | 1998 |
Determination of theophylline by HPLC and GC-IDMS, the effect of chemically similar xanthine derivatives on the specificity of the method and the possibility of paracetamol as interfering substance.
Topics: Acetaminophen; Calibration; Chemical Precipitation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Sensitivity and Specificity; Theophylline; Trichloroacetic Acid; Xanthines | 2002 |
Prediction of in vivo drug release behavior of controlled-release multiple-unit dosage forms in dogs using a flow-through type dissolution test method.
Topics: Acetaminophen; Administration, Oral; Animals; Biological Availability; Cellulose; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Dogs; Drug Carriers; Forecasting; Intestinal Absorption; Male; Models, Biological; Phenylpropanolamine; Solubility; Theophylline | 2003 |
Pharmaceutical applications of shellac: moisture-protective and taste-masking coatings and extended-release matrix tablets.
Topics: Acetaminophen; Aspirin; Delayed-Action Preparations; Drug Stability; Humans; Hypromellose Derivatives; Methylcellulose; Resins, Plant; Solubility; Taste; Theophylline; Verapamil; Wettability | 2003 |
Component analysis of illicit heroin samples with GC/MS and its application in source identification.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimulants; Codeine; Drug Contamination; Gas Chromatography-Mass Spectrometry; Heroin; Illicit Drugs; Morphine Derivatives; Narcotics; Theophylline; Vasodilator Agents | 2004 |
[For which cases should clinicians perform blood purification in the management of acute poisoning? Clinical and pharmacological analyses].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Cost-Benefit Analysis; Female; Hemodiafiltration; Hemoperfusion; Humans; Hypnotics and Sedatives; Male; Middle Aged; Poisoning; Psychotropic Drugs; Renal Dialysis; Retrospective Studies; Theophylline | 2004 |
The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Non-Narcotic; Animals; Blotting, Western; Bronchodilator Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Models, Biological; Pan troglodytes; Pharmaceutical Preparations; Pharmacokinetics; Propranolol; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Verapamil | 2004 |
Proabsorptive action of gum arabic in isotonic solutions orally administered to rats. II. Effects on solutes under normal and secretory conditions.
Topics: Acetaminophen; Administration, Oral; Animals; Area Under Curve; Biological Availability; Disease Models, Animal; Drug Interactions; Female; Gum Arabic; Intestinal Absorption; Intestinal Mucosa; Isotonic Solutions; Probability; Rats; Rats, Sprague-Dawley; Rehydration Solutions; Sensitivity and Specificity; Theophylline; Time Factors | 2004 |
Hot air coating technique as a novel method to produce microparticles.
Topics: Acetaminophen; Air; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Compounding; Drug Delivery Systems; Excipients; Heating; Microscopy, Electron, Scanning; Particle Size; Solubility; Stearic Acids; Theophylline; Time Factors | 2004 |
[Simultaneous determination of josamycin, theophylline and paracetamol in pharmaceutical waste water by high performance liquid chromatography].
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Drug Industry; Industrial Waste; Josamycin; Theophylline | 2005 |
Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. II. Influence of drug and filler type.
Topics: Acetaminophen; Carrageenan; Cellulose; Chemistry, Pharmaceutical; Drug Implants; Excipients; Mesalamine; Particle Size; Solubility; Surface Properties; Technology, Pharmaceutical; Tensile Strength; Theophylline; Water | 2006 |
Method for screening and quantitative determination of serum levels of salicylic Acid, acetaminophen, theophylline, phenobarbital, bromvalerylurea, pentobarbital, and amobarbital using liquid chromatography/electrospray mass spectrometry.
Topics: Acetaminophen; Acidosis; Adult; Amobarbital; Analgesics, Non-Narcotic; Bromisovalum; Calibration; Chromatography, Liquid; Female; Humans; Hypnotics and Sedatives; Indicators and Reagents; Pentobarbital; Phenobarbital; Reproducibility of Results; Salicylic Acid; Spectrometry, Mass, Electrospray Ionization; Theophylline; Vasodilator Agents | 2006 |
A quick method for the quantitative analysis of mixtures. 1. Powder X-ray diffraction.
Topics: Acetaminophen; Algorithms; Crystallography, X-Ray; Excipients; Fluconazole; Inosine; Lactose; Least-Squares Analysis; Linear Models; Models, Chemical; Pharmaceutical Preparations; Powder Diffraction; Powders; Reproducibility of Results; Technology, Pharmaceutical; Theophylline | 2008 |
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets.
Topics: Acetaminophen; Caffeine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Excipients; Hydrochlorothiazide; Hypromellose Derivatives; Ketoprofen; Methylcellulose; Metoprolol; Molecular Weight; Particle Size; Solubility; Tablets; Theophylline; Viscosity | 2007 |
Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
Topics: Acetaminophen; Antipyrine; Aspirin; Beverages; Biological Products; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Codeine; Cosmetics; Food Analysis; Linear Models; Pharmaceutical Preparations; Salicylic Acid; Theobromine; Theophylline | 2008 |
A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens.
Topics: Acetaminophen; Analgesics; Anticonvulsants; Bronchodilator Agents; Caffeine; Calibration; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Histamine H2 Antagonists; Humans; Infant, Newborn; Phenytoin; Quality Control; Ranitidine; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Theophylline | 2008 |
Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets.
Topics: Acetaminophen; Cellulose; Chemistry, Pharmaceutical; Diltiazem; Drug Carriers; Drug Delivery Systems; Metoprolol; Polyethylene Glycols; Polymers; Polyvinyl Alcohol; Tablets, Enteric-Coated; Technology, Pharmaceutical; Temperature; Theophylline | 2009 |
Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs.
Topics: Absorption; Acetaminophen; Animals; Antipyrine; Dosage Forms; Drug Carriers; Drug Delivery Systems; Drug Evaluation, Preclinical; Excipients; Hydrogen-Ion Concentration; Hypromellose Derivatives; Intestine, Small; Male; Methylcellulose; Permeability; Rats; Rats, Wistar; Solubility; Theophylline | 2009 |
Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.
Topics: Acetaminophen; Animals; Anthracenes; Cell Line; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Indomethacin; Interleukin-1beta; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mice; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction; Theophylline; Tumor Necrosis Factor-alpha | 2009 |
Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient.
Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Antihypertensive Agents; Combined Modality Therapy; Critical Care; Diuresis; Drug Overdose; Fluid Therapy; Hemodynamics; Humans; Hypokalemia; Hypotension; Indapamide; Infusions, Intravenous; Male; Methyldopa; Norepinephrine; Plasma Substitutes; Polygeline; Suicide, Attempted; Theophylline; Treatment Outcome; Vasoconstrictor Agents | 2009 |
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.
Topics: Absenteeism; Acetaminophen; Adolescent; Dipyrone; Drug Combinations; Dysmenorrhea; Female; Humans; Menarche; Mexico; Naproxen; Nonprescription Drugs; Pain; Prevalence; Propanolamines; Pyrilamine; Scopolamine; Severity of Illness Index; Students; Theophylline; Universities; Young Adult | 2010 |
Transmission electron microscopy of pharmaceutical materials.
Topics: Acetaminophen; Caffeine; Crystallization; Microscopy, Electron, Transmission; Oxalic Acid; Pharmaceutical Preparations; Ranitidine; Theophylline | 2010 |
Design and in vitro evaluation of a film-controlled dosage form self-converted from monolithic tablet in gastrointestinal environment.
Topics: Acetaminophen; Alginates; Aspirin; Calorimetry, Differential Scanning; Chitosan; Delayed-Action Preparations; Electrolytes; Gastrointestinal Tract; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Pharmaceutical Preparations; Polymers; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; Theophylline | 2010 |
Inkjet printing of drug substances and use of porous substrates-towards individualized dosing.
Topics: Acetaminophen; Administration, Oral; Caffeine; Chromatography, Liquid; Dosage Forms; Mass Spectrometry; Paper; Pharmaceutical Preparations; Porosity; Precision Medicine; Printing; Solutions; Technology, Pharmaceutical; Theophylline | 2011 |
Cocrystal intrinsic dissolution behavior using a rotating disk.
Topics: Acetaminophen; Crystallization; Hydrogen-Ion Concentration; Models, Chemical; Solubility; Theophylline | 2011 |
Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization.
Topics: Acetaminophen; Chemistry, Pharmaceutical; Furosemide; Hydrochlorothiazide; Particle Size; Solubility; Technology, Pharmaceutical; Tensile Strength; Theophylline | 2011 |
Molecular dynamics simulations of CYP2E1.
Topics: Acetaminophen; Aniline Compounds; Benzene; Biocatalysis; Catalytic Domain; Chlorzoxazone; Crystallography, X-Ray; Cytochrome P-450 CYP2E1; Models, Molecular; Molecular Dynamics Simulation; Structure-Activity Relationship; Theophylline | 2012 |
Delayed subdural haematoma complicated by abducens nerve palsy and cortical vein thrombosis after obstetric epidural anaesthesia.
Topics: Abducens Nerve; Abducens Nerve Diseases; Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthesia, Epidural; Anesthesia, Obstetrical; Anticoagulants; Blood Patch, Epidural; Female; Follow-Up Studies; Hematoma, Subdural; Heparin, Low-Molecular-Weight; Humans; Magnetic Resonance Imaging; Post-Dural Puncture Headache; Pregnancy; Spinal Puncture; Theophylline; Thrombosis | 2012 |
Polymorph identification and crystal structure determination by a combined crystal structure prediction and transmission electron microscopy approach.
Topics: Acetaminophen; Crystallization; Electrons; Inositol; Microscopy, Electron, Transmission; Molecular Structure; Theophylline; X-Ray Diffraction | 2013 |
Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film.
Topics: Acetaminophen; Alginates; Cellulose; Chitosan; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Metformin; Osmolar Concentration; Stearic Acids; Tablets; Theophylline; Trimetazidine | 2013 |
Investigation of critical core formulation and process parameters for osmotic pump oral drug delivery.
Topics: Acetaminophen; Administration, Oral; Chemistry, Pharmaceutical; Dosage Forms; Drug Delivery Systems; Membrane Transport Proteins; Osmosis; Polyethylene Glycols; Polymers; Solubility; Tablets; Theophylline; Verapamil | 2014 |
Erythema multiforme secondary to dimenhydrinate in a patient with previous similar reactions to pamabrom.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antiemetics; Dimenhydrinate; Drug Combinations; Erythema Multiforme; Female; Humans; Propanolamines; Theophylline; Young Adult | 2014 |
Optical microscopy as a comparative analytical technique for single-particle dissolution studies.
Topics: Acetaminophen; Aspirin; Kinetics; Microscopy; Particle Size; Powders; Reproducibility of Results; Solubility; Spectrophotometry, Ultraviolet; Technology, Pharmaceutical; Theophylline | 2014 |
HPTLC and RP-HPLC methods for simultaneous determination of Paracetamol and Pamabrom in presence of their potential impurities.
Topics: Acetaminophen; Acetic Acid; Acetonitriles; Aminophenols; Buffers; Calibration; Chloroform; Chromatography, High Pressure Liquid; Drug Combinations; Drug Contamination; Hydrogen-Ion Concentration; Light; Methanol; Phosphates; Propanolamines; Reproducibility of Results; Tablets; Tablets, Enteric-Coated; Theophylline | 2015 |
Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds.
Topics: Acetaminophen; Administration, Oral; Biopharmaceutics; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant, Premature; Intestinal Absorption; Theophylline | 2016 |
Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding.
Topics: Acetaminophen; Administration, Oral; Chemistry, Pharmaceutical; Crystallization; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Dyphylline; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Polyurethanes; Solubility; Tablets; Technology, Pharmaceutical; Theophylline | 2016 |
Stability Orders of Acetaminophen and Theophylline Co-crystals Determined by Co-crystal Former Exchange Reactions and Their Correlation With In Silico and Thermal Parameters.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Bronchodilator Agents; Crystallization; Drug Stability; Hydrogen Bonding; Maleates; Models, Molecular; Oxalic Acid; Powder Diffraction; Theophylline; Thermodynamics; X-Ray Diffraction | 2017 |
Development and applications of a physiologically-based model of paediatric oral drug absorption.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Biopharmaceutics; Chemistry, Pharmaceutical; Child; Child, Preschool; Gastrointestinal Tract; Humans; Infant; Infant, Newborn; Intestinal Absorption; Ketoconazole; Pharmaceutical Preparations; Solubility; Theophylline; Young Adult | 2018 |
Exploratory studies in heat-assisted continuous twin-screw dry granulation: A novel alternative technique to conventional dry granulation.
Topics: Acetaminophen; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Delayed-Action Preparations; Drug Compounding; Drug Stability; Drug Storage; Excipients; Hot Temperature; Lidocaine; Tablets; Technology, Pharmaceutical; Theophylline; Transition Temperature; X-Ray Diffraction | 2019 |
Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration.
Topics: Acetaminophen; Calcium Carbonate; Cellulose; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Excipients; Humans; Kinetics; Porosity; Tablets; Terahertz Spectroscopy; Theophylline | 2020 |
Well-tempered MCMC simulations for population pharmacokinetic models.
Topics: Acetaminophen; Algorithms; Bayes Theorem; Biological Variation, Population; Humans; Markov Chains; Models, Biological; Monte Carlo Method; Software; Theophylline | 2020 |
Electrochemical sensing platform based on covalent organic framework materials and gold nanoparticles for high sensitivity determination of theophylline and caffeine.
Topics: Acetaminophen; Caffeine; Capsules; Drug Contamination; Electrochemical Techniques; Electrodes; Gold; Limit of Detection; Metal Nanoparticles; Metal-Organic Frameworks; Reproducibility of Results; Tea; Theophylline | 2021 |
Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups.
Topics: Acetaminophen; Administration, Oral; Adolescent; Child; Child, Preschool; Computer Simulation; Data Interpretation, Statistical; Emtricitabine; Humans; Infant; Infant, Newborn; Intestinal Absorption; Models, Biological; Pediatrics; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Solubility; Theophylline; Zolpidem | 2021 |