acetaminophen has been researched along with simvastatin in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX | 1 |
| Abu-Rabie, P; Spooner, N | 1 |
| Gumbrevičius, G; Stankevičius, E; Sveikata, A; Sveikatienė, R | 1 |
| Arnold, C; Barras, D; Bodenmann, P; Chiarini, B; Guinand, S; Pasche, O; Ronga, A; Vu, F; Zürcher, S | 1 |
| Damen, CW; González, O; Hankemeier, T; van der Kloet, FM; van Vliet, M; Vreeken, RJ | 1 |
| Löbmann, K; Rades, T; Sibik, J; Zeitler, JA | 1 |
| Cui, R; Feng, Y; Liang, H; Liu, C; Qiu, M; Zhang, J | 1 |
| Beck, A; Flockerzi, V; Maurer, HH; Meyer, MR; Richter, LHJ | 1 |
| Burrows, HD; Encarnação, T; Pais, AACC; Palito, C; Valente, AJM | 1 |
| Alsubih, M; Balakrishnan, D; El Morabet, R; Khan, AR; Khan, NA; Khan, RA; Khan, S; Khoo, KS; Mubashir, M | 1 |
1 review(s) available for acetaminophen and simvastatin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
22 other study(ies) available for acetaminophen and simvastatin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles | 2008 |
Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface.
Topics: Acetaminophen; Aminoquinolines; Benzethonium; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Humans; Ibuprofen; Mass Spectrometry; Phthalic Acids; Proguanil; Sensitivity and Specificity; Simvastatin | 2009 |
Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Coronary Artery Bypass; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Jaundice; Liver; Myocardial Infarction; Nausea; Simvastatin; Vomiting | 2012 |
[2014 literature findings in internal general medicine].
Topics: Acetaminophen; Adolescent; Aged; Analgesics, Non-Narcotic; Bronchitis; Bullying; Colorectal Neoplasms; Early Detection of Cancer; Fibrinolytic Agents; Fractures, Bone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Internal Medicine; Internet; Leg Bones; Low Back Pain; Menisci, Tibial; Middle Aged; Rotator Cuff; Simvastatin; Varicose Ulcer | 2015 |
Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion.
Topics: Acetaminophen; Benzimidazoles; Benzoates; Biphenyl Compounds; Chromatography, High Pressure Liquid; Clomipramine; Dihydropyridines; Enkephalin, Leucine; Humans; Mass Spectrometry; Nifedipine; Pharmaceutical Preparations; Simvastatin; Telmisartan; Tetrazoles; Time Factors | 2015 |
Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy.
Topics: Acetaminophen; Calorimetry, Differential Scanning; Crystallization; Drug Stability; Flufenamic Acid; Indomethacin; Kinetics; Molecular Dynamics Simulation; Naproxen; Simvastatin; Temperature; Terahertz Spectroscopy; X-Ray Diffraction | 2015 |
Simvastatin protects against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2018 |
Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.
Topics: Acetaminophen; Alkaloids; Biological Assay; Chromatography, Liquid; Fluorescent Dyes; Fluvastatin; Hep G2 Cells; Hepatocytes; Humans; Illicit Drugs; Indans; Indoles; Membrane Potential, Mitochondrial; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Propranolol; Quinolines; Simvastatin; Tandem Mass Spectrometry; Toxicity Tests | 2019 |
Removal of Pharmaceuticals from Water by Free and Imobilised Microalgae.
Topics: Acetaminophen; Biodegradation, Environmental; Cells, Immobilized; Endocrine Disruptors; Ibuprofen; Microalgae; Pharmaceutical Preparations; Polyvinyl Alcohol; Simvastatin; Water Pollutants, Chemical | 2020 |
Comparison of constructed wetland performance coupled with aeration and tubesettler for pharmaceutical compound removal from hospital wastewater.
Topics: Acetaminophen; Animals; Carbamazepine; Ciprofloxacin; Erythromycin; Hospitals; Ibuprofen; Lorazepam; Pharmaceutical Preparations; Simvastatin; Waste Disposal, Fluid; Wastewater; Wetlands | 2023 |