acetaminophen has been researched along with s-adenosylmethionine in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, C; Gonzalez, FJ; Idle, JR; Krausz, KW; Shah, YM | 1 |
| Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD | 1 |
| Beger, RD; Bhattacharyya, S; Gill, P; James, LP; Kearns, GL; Letzig, LG; Marshall, JD; Pence, L; Reed, MD; Simpson, PM; Sullivan, JE; Van Den Anker, JN; Yan, K | 1 |
| Galli-Kienle, M; Pezzoli, C; Stramentinoli, G | 1 |
| Fullerton, FR; Hathcock, JN; Poirier, LA; Reicks, MM; Whittaker, P | 1 |
| Bray, GP; Tredger, JM; Williams, R | 1 |
| Castell, JV; Fabra, R; Gómez-Lechón, MJ; Jover, R; Ponsoda, X; Trullenque, R | 1 |
| Ragel, C; Ruiz-Roso, B; Varela-Moreiras, G | 1 |
| Batlle, AM; Noriega, GO; Ossola, JO; Tomaro, ML | 1 |
| Carrasco, R; Caturla, J; Esteban, A; Gutiérrez, A; Mayol, MJ; Ortiz, P; Pérez-Mateo, M | 1 |
| Varela-Moreiras, G | 1 |
| Fettman, MJ; Mason, G; Twedt, DC; Webb, CB | 1 |
| Chen, T; McClain, CJ; Song, Z | 1 |
| Carpenter, AB; Harmon, RC; Terneus, M; Valentovic, M | 1 |
| Carpenter, AB; Kiningham, KK; Sullivan, SB; Terneus, MV; Valentovic, MA | 1 |
| Brown, JM; Carpenter, AB; Terneus, MV; Valentovic, MA | 1 |
| Beger, RD; Schnackenberg, LK; Sun, J | 1 |
| Ball, JG; Brown, JM; Hogsett, A; Valentovic, M; Williams, T | 1 |
| Ball, JG; Michael Brown, J; Valentovic, MA; Van Meter, S; Wright, MS | 1 |
| Ball, JG; Brown, JM; Kuhlman, C; Labenski, MT; Lamyaithong, AB; Lau, SS; Terneus, MV; Valentovic, MA | 1 |
| Anilkumar, N; Brandes, RP; Brewer, AC; Burr, S; Caldwell, A; Dew, T; Dong, X; Halket, J; Hughes, RD; Martin, D; Mistry, RK; Murray, TV; Quaglia, A; Sawyer, GJ; Schröder, K; Shah, AM; Sherwood, R | 1 |
| Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H | 1 |
| Cho, E; Jung, S; Kim, J; Ko, KS | 1 |
2 review(s) available for acetaminophen and s-adenosylmethionine
| Article | Year |
|---|---|
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and Drug Induced Liver Injury; Child; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycyrrhizic Acid; Humans; Infant, Newborn; Liver; Liver Failure, Acute; Retrospective Studies; S-Adenosylmethionine; Ursodeoxycholic Acid | 2022 |
1 trial(s) available for acetaminophen and s-adenosylmethionine
| Article | Year |
|---|---|
S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury.
Topics: Acetaminophen; Animals; Antioxidants; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Erythrocytes; Glutathione; Glutathione Disulfide; Liver; S-Adenosylmethionine; Thiobarbituric Acid Reactive Substances; Time Factors | 2003 |
20 other study(ies) available for acetaminophen and s-adenosylmethionine
| Article | Year |
|---|---|
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytochrome P-450 CYP2E1; Fatty Acids; Glutathione; Liver Diseases; Mass Spectrometry; Metabolomics; Mice; Mice, Knockout; PPAR alpha; Time Factors | 2009 |
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mitochondria | 2014 |
Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Age Factors; Alanine Transaminase; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Discriminant Analysis; Female; Humans; Least-Squares Analysis; Male; Mass Spectrometry; Metabolomics; Sex Factors | 2014 |
Protective role of S-adenosyl-l-methionine against acetaminophen induced mortality and hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzymes; Glutathione; Liver; Mice; Protein Binding; S-Adenosylmethionine | 1979 |
Prolonged acetaminophen ingestion by mice fed a methionine-limited diet does not affect iron-induced liver lipid peroxidation or S-adenosylmethionine.
Topics: Acetaminophen; Animals; Cysteine; Glutathione; Glutathione Peroxidase; Iron; Lipid Peroxidation; Liver; Male; Methionine; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 1992 |
S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mortality; S-Adenosylmethionine | 1992 |
Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs.
Topics: Acetaminophen; Cells, Cultured; Dose-Response Relationship, Drug; Ethanol; Glutathione; Heroin; Humans; Liver; Methadone; Narcotics; S-Adenosylmethionine | 1991 |
Effects of prolonged aspirin or acetaminophen administration to rats on liver folate content and distribution. Relation to DNA methylation and S-adenosylmethionine.
Topics: Acetaminophen; Animals; Aspirin; DNA; Drug Administration Schedule; Folic Acid; Liver; Male; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Effect of acetaminophen on heme metabolism in rat liver.
Topics: 5-Aminolevulinate Synthetase; Acetaminophen; Animals; Bilirubin; Female; Heme; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; S-Adenosylmethionine | 2000 |
Effect of different doses of S-adenosyl-L-methionine on paracetamol hepatotoxicity in a mouse model.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Female; Free Radical Scavengers; Liver; Liver Failure; Mice; S-Adenosylmethionine | 2000 |
S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics; Animals; Cell Membrane Permeability; Chemical and Drug Induced Liver Injury; Cytosol; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Necrosis; S-Adenosylmethionine | 2004 |
S-Adenosylmethionine (SAMe) attenuates acetaminophen hepatotoxicity in C57BL/6 mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; S-Adenosylmethionine | 2004 |
Comparison of S-Adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity.
Topics: Acetaminophen; Acetylcysteine; Aldehydes; Animals; Antidotes; Blotting, Western; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL; Organ Size; Protein Carbonylation; S-Adenosylmethionine | 2007 |
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aldehydes; Analysis of Variance; Animals; Blotting, Western; Drug Overdose; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Microscopy, Polarization; Organ Size; Protein Carbonylation; S-Adenosylmethionine; Time Factors | 2008 |
Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Creatine; Dose-Response Relationship, Drug; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Metabolomics; Principal Component Analysis; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Sulfates | 2009 |
Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity.
Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Drug Interactions; Intracellular Space; Liver; Male; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Organ Size; Protective Agents; S-Adenosylmethionine | 2010 |
Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Antagonism; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Stress; Oxidoreductases; Protein Carbonylation; S-Adenosylmethionine | 2012 |
S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.
Topics: Acetaminophen; Aldehydes; Animals; Antioxidants; Carbamoyl-Phosphate Synthase (Ammonia); Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytoprotection; Disease Models, Animal; Liver; Male; Mice, Inbred BALB C; Mitochondria, Liver; Oxidative Stress; Protein Carbonylation; Protein Processing, Post-Translational; S-Adenosylmethionine; Sarcosine Dehydrogenase; Tandem Mass Spectrometry | 2014 |
NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Betaine; Blotting, Western; Cells, Cultured; Cysteine; Female; Glutathione; Hep G2 Cells; Homocysteine; Humans; Immunoenzyme Techniques; Liver; Liver Diseases; Methionine; Mice; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; Reactive Oxygen Species; S-Adenosylmethionine | 2015 |
The Relationship between Prohibitin 1 Expression, Hepatotoxicity Induced by Acetaminophen, and Hepatoprotection by S-Adenosylmethionine in AML12 Cells.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Prohibitins; S-Adenosylmethionine | 2022 |