acetaminophen has been researched along with rofecoxib in 56 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 50 (89.29) | 29.6817 |
2010's | 6 (10.71) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Bird, SR; Bohidar, NR; Chang, DJ; Dobbins, TW; Fricke, JR; Geba, GP | 1 |
Catella-Lawson, F; Cucchiara, AJ; DeMarco, S; FitzGerald, GA; Kapoor, SC; Reilly, MP; Tournier, B; Vyas, SN | 1 |
Dixon, ME; Geba, GP; Polis, AB; Schnitzer, TJ; Weaver, AL | 1 |
McColl, GJ | 1 |
Bridge, HS; Nolan, J; Pickering, AE; Stoddart, PA | 1 |
Berger, MY; Bierma-Zeinstra, SM; Bohnen, AM; Thomas, S | 1 |
Henderson, P | 1 |
Day, RO; Graham, GG; Graham, RI | 1 |
Hu, J; Ing, C; Issioui, T; Jones, SB; Klein, KW; Marple, BF; Skrivanek, GD; Watcha, MF; White, PF | 1 |
Issioui, T; Klein, KW; Watcha, MF; White, PF | 1 |
Connelly, NR; Joshi, W; Reuben, SS; Thakkar, N; Wolckenhaar, M | 1 |
Chow, KM; Lai, FM; Li, P; Szeto, CC | 1 |
Castello, JV; de Mateo, JA; Enrique, E; Malek, T; Roca, B; Rodríguez, M | 1 |
Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC | 1 |
Shintani, EY; Skinner, HB | 1 |
Bird, SR; Black, P; Chang, DJ; Chen, E; Desjardins, PJ; Geba, GP; Petruschke, RA | 1 |
Fricke, JR; Korn, S; Kotey, PN; Vassil, TC | 1 |
Battisti, WP; Geba, GP; Katz, NP; Kivitz, AJ; Matsumoto, AK; Polis, AB; Weaver, AL | 1 |
Almekinders, LC; Rahusen, FT; Weinhold, PS | 1 |
Lizán Tudela, L; Magaz Marqués, S; Riesgo Bucher, Y; Varela Moreno, C | 1 |
Liu, W; Loo, CC; Ren, HZ; Tan, HM; Ye, TH | 1 |
Lucas, R; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
Afshari, HM; Dahners, LE; Hanson, CA; Weinhold, PS | 1 |
Geba, GP; Petruschke, RA; Polis, AB; Schnitzer, TJ; Weaver, AL | 1 |
Asero, R | 2 |
Bird, SR; Bohidar, NR; Chang, DJ; King, T | 1 |
Ammar, MM; Gilbert, JG; Khrapov, AV; McClintock, A; Naesh, O; Niles, LA; Phibbs, PW; Phillips, AM; Robert, AJ | 1 |
Cadeddu, JA; Duchene, D; Johnson, DB; Recart, A; Thomas, T; White, PF | 1 |
Aeschlimann, A; Gay, RE; Gay, S; Michel, BA; Shen, H; Sprott, H | 1 |
Church, CA; O-Lee, TJ; Stewart, C; Wallace, D | 1 |
Bountra, C; Chessell, IP; Day, NC; Staton, PC; Wilson, AW | 1 |
Cağici, CA; Calişkan, EE; Erkan, AN; Gencay, S; Ozlüoğlu, LN; Sener, M; Yavuz, H; Yilmaz, I; Yilmazer, C | 1 |
Haglund, B; von Bültzingslöwen, I | 1 |
Alleyne, CH; French, A; Macomson, SD; Rahimi, SY; Smith, JR; Vender, JR | 1 |
Chelly, JE; Nissen, CW; Rodgers, AJ; Smugar, SS; Tershakovec, AM | 1 |
Nedjar, H; Rahme, E | 1 |
Barozzi, N; Tett, SE | 2 |
Bird, SR; Black, PM; Chang, DJ; Daniels, SE; Desjardins, PJ; Petruschke, RA; Smugar, SS; Tershakovec, AM | 1 |
Bean-Lijewski, JD; Browne, B; Hutchinson, L; Kruitbosch, SH | 1 |
Carignan, M; Dorion, D; Lafrenaye, S; Vallée, E | 1 |
Brahim, JS; Chuang, BP; Dionne, RA; Gordon, SM; Hamza, MA; Rowan, JS; Wang, XM | 1 |
Altman, RD; Cooper, KM; Schnitzer, TJ; Tesser, JR | 1 |
Ashok, V; Dash, C; Rohan, TE; Sprafka, JM; Terry, PD | 1 |
McGettigan, P; Waring, WS | 1 |
3 review(s) available for acetaminophen and rofecoxib
Article | Year |
---|---|
Pharmacological therapies for the treatment of osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase Inhibitors; Humans; Lactones; Pyrazoles; Sulfonamides; Sulfones | 2001 |
Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesia; Cardiovascular System; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Kidney; Lactones; Liver; Membrane Proteins; Osteoarthritis; Pain; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones | 2002 |
[Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Costs and Cost Analysis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Decision Trees; Hip Joint; Humans; Joint Diseases; Knee Joint; Lactones; Membrane Proteins; Pain; Prostaglandin-Endoperoxide Synthases; Severity of Illness Index; Sulfones | 2004 |
29 trial(s) available for acetaminophen and rofecoxib
Article | Year |
---|---|
Rofecoxib versus codeine/acetaminophen in postoperative dental pain: a double-blind, randomized, placebo- and active comparator-controlled clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrocodone; Lactones; Male; Pain Measurement; Pain, Postoperative; Sulfones; Time Factors; Tooth Extraction; Treatment Outcome | 2001 |
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Interactions; Drug Therapy, Combination; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2 | 2001 |
Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Osteoarthritis, Knee; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones | 2002 |
Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children.
Topics: Acetaminophen; Adenoidectomy; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Child; Child, Preschool; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ibuprofen; Infant; Lactones; Male; Pain, Postoperative; Premedication; Sulfones; Tonsillectomy | 2002 |
Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit Analysis; Costs and Cost Analysis; Double-Blind Method; Female; Humans; Lactones; Male; Middle Aged; Otorhinolaryngologic Surgical Procedures; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Postoperative Nausea and Vomiting; Sulfones | 2002 |
Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Opioid; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Lactones; Male; Middle Aged; Otorhinolaryngologic Surgical Procedures; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Postoperative Nausea and Vomiting; Pyrazoles; Sulfonamides; Sulfones | 2003 |
An evaluation of the safety and efficacy of administering rofecoxib for postoperative pain management.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Codeine; Female; Hemorrhage; Humans; Lactones; Male; Pain Measurement; Pain, Postoperative; Postoperative Complications; Sulfones; Tonsillectomy | 2003 |
Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Combinations; Female; Humans; Lactones; Male; Middle Aged; Narcotics; Osteoarthritis; Pain; Placebos; Pyrazoles; Sulfonamides; Sulfones; Tramadol; Treatment Outcome | 2004 |
Comparison of rofecoxib and a multidose oxycodone/ acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lactones; Male; Oxycodone; Pain; Placebos; Sulfones; Surgery, Oral; Treatment Outcome | 2004 |
Comparison of rofecoxib and oxycodone plus acetaminophen in the treatment of acute pain: a randomized, double-blind, placebo-controlled study in patients with moderate to severe postoperative pain in the third molar extraction model.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Combinations; Female; Humans; Lactones; Male; Oxycodone; Pain, Postoperative; Sulfones; Tooth Extraction | 2004 |
Pain management in osteoarthritis: a focus on onset of efficacy--a comparison of rofecoxib, celecoxib, acetaminophen, and nabumetone across four clinical trials.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Butanones; Celecoxib; Humans; Lactones; Nabumetone; Osteoarthritis, Knee; Pyrazoles; Sulfonamides; Sulfones; Treatment Outcome | 2004 |
[Comparison of preemptive analgesia efficacy between etoricoxib and rofecoxib in ambulatory gynecological surgery].
Topics: Abortion, Induced; Acetaminophen; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Etoricoxib; Female; Fentanyl; Humans; Lactones; Pain Measurement; Pain, Postoperative; Preoperative Care; Pyridines; Sulfones | 2004 |
Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Lactones; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Pyrazoles; Severity of Illness Index; Sulfonamides; Sulfones; Treatment Outcome | 2005 |
Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Cyclooxygenase Inhibitors; Drug Evaluation; Female; Humans; Lactones; Male; Middle Aged; ortho-Aminobenzoates; Recurrence; Single-Blind Method; Sulfonamides; Sulfones; Tramadol; Urticaria | 2005 |
Analgesic efficacy of rofecoxib compared with codeine/acetaminophen using a model of acute dental pain.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Codeine; Consumer Product Safety; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Combinations; Facial Pain; Female; Humans; Lactones; Logistic Models; Male; Molar, Third; Pain, Postoperative; Sulfones; Tooth Extraction | 2005 |
A randomized, placebo-controlled study of rofecoxib with paracetamol in early post-tonsillectomy pain in adults.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Lactones; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Preanesthetic Medication; Sulfones; Tonsillectomy | 2005 |
Efficacy and safety of fast-track recovery strategy for patients undergoing laparoscopic nephrectomy.
Topics: Acetaminophen; Adult; Aged; Analgesics; Antiemetics; Cyclooxygenase 2 Inhibitors; Female; Histamine H2 Antagonists; Humans; Kidney Neoplasms; Lactones; Laparoscopy; Length of Stay; Male; Middle Aged; Nephrectomy; Pain, Postoperative; Postoperative Care; Postoperative Nausea and Vomiting; Preoperative Care; Ranitidine; Sulfones | 2005 |
Analgesic action of acetaminophen in symptomatic osteoarthritis of the knee.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; beta-Endorphin; Biomarkers; Cyclooxygenase 2 Inhibitors; Female; Humans; Knee Joint; Lactones; Male; Middle Aged; Osteoarthritis, Knee; Pain Measurement; Serotonin; Severity of Illness Index; Substance P; Sulfones; Treatment Outcome | 2006 |
Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Endoscopy; Female; Follow-Up Studies; Humans; Hydrocodone; Lactones; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Paranasal Sinus Diseases; Prospective Studies; Sulfones; Treatment Outcome | 2006 |
[Postoperative pain management in clinics of otolaryngology].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Dipyrone; Etodolac; Female; Humans; Lactones; Male; Meloxicam; Middle Aged; Naproxen; Otorhinolaryngologic Surgical Procedures; Pain Measurement; Pain, Postoperative; Postoperative Period; Sulfones; Thiazines; Thiazoles; Treatment Outcome | 2006 |
Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute pain relief after third molar surgery: a randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cohort Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Follow-Up Studies; Humans; Ibuprofen; Lactones; Male; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Placebos; Sulfones; Tooth Extraction; Treatment Outcome | 2006 |
Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross Reactions; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Female; Humans; Ketoprofen; Lactones; Male; Middle Aged; Placebos; Sulfonamides; Sulfones; Tramadol; Urticaria | 2006 |
Postoperative pain management after craniotomy: evaluation and cost analysis.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Craniotomy; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hospital Costs; Humans; Injections, Intravenous; Lactones; Length of Stay; Male; Middle Aged; Morphine; Narcotics; Oxycodone; Pain Measurement; Pain, Postoperative; Single-Blind Method; Sulfones; Treatment Outcome | 2006 |
The efficacy of rofecoxib 50 mg and hydrocodone/acetaminophen 7.5/750 mg in patients with post-arthroscopic pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Arthroscopy; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrocodone; Knee Joint; Lactones; Logistic Models; Male; Pain Measurement; Pain, Postoperative; Sulfones; Treatment Outcome | 2007 |
A double-blind randomized controlled trial of rofecoxib and multidose oxycodone/acetaminophen in dental impaction pain.
Topics: Acetaminophen; Adult; Analgesics; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Lactones; Male; Molar, Third; Oxycodone; Pain Measurement; Pain, Postoperative; Sulfones; Tooth Extraction; Tooth, Impacted | 2007 |
Post-tonsillectomy pain management in children: can we do better?
Topics: Acetaminophen; Adolescent; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Combinations; Elective Surgical Procedures; Follow-Up Studies; Humans; Hydrocodone; Lactones; Pain Measurement; Pain, Postoperative; Prospective Studies; Sulfones; Time Factors; Tonsillectomy; Treatment Outcome | 2007 |
Comparative study of acetaminophen-morphine versus rofecoxib-morphine for post-tonsillectomy pain control.
Topics: Acetaminophen; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Humans; Lactones; Male; Morphine; Pain Measurement; Pain, Postoperative; Sulfones; Tonsillectomy | 2007 |
The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Codeine; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Double-Blind Method; Enzyme Induction; Female; Humans; Lactones; Lidocaine; Male; Molar, Third; Mouth Mucosa; Oral Surgical Procedures; Pain Measurement; Pain, Postoperative; Sulfones; Time Factors; Tooth, Impacted | 2008 |
A 4-week randomized study of acetaminophen extended-release vs rofecoxib in knee osteoarthritis.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cyclooxygenase 2 Inhibitors; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Female; Humans; Lactones; Male; Middle Aged; Osteoarthritis, Knee; Pain Measurement; Severity of Illness Index; Sulfones; Treatment Outcome | 2009 |
24 other study(ies) available for acetaminophen and rofecoxib
Article | Year |
---|---|
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
[Cox-2 inhibitors in the focus. Rofecoxib as effective as the "classics"].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lactones; Morphine; Pain, Postoperative; Pyrazoles; Risk Factors; Spinal Fusion; Sulfonamides; Sulfones; Time Factors | 2001 |
[Effective not only in rheumatism and arthrosis. Rofecoxib fights also acute pain].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Codeine; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Humans; Lactones; Middle Aged; Pain; Randomized Controlled Trials as Topic; Sulfones; Tooth Extraction | 2002 |
Rofecoxib vs celecoxib vs acetaminophen for treatment of osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Lactones; Osteoarthritis; Pyrazoles; Sulfonamides; Sulfones | 2002 |
Rofecoxib vs celecoxib vs acetaminophen for treatment of osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Lactones; Osteoarthritis; Pyrazoles; Sulfonamides; Sulfones | 2002 |
Acute interstitial nephritis and COX-2 inhibition.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Isoenzymes; Lactones; Membrane Proteins; Nephritis, Interstitial; Prostaglandin-Endoperoxide Synthases; Sulfones | 2003 |
Tolerability of cyclooxygenase 2 inhibitors and the advisability of oral challenge.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Eruptions; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Urticaria | 2003 |
Results of a multimodal analgesic trial involving patients with total hip or total knee arthroplasty.
Topics: Acetaminophen; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Bupivacaine; Dexamethasone; Female; Humans; Lactones; Length of Stay; Male; Middle Aged; Pain, Postoperative; Retrospective Studies; Sulfones; Tramadol | 2004 |
Nonsteroidal anti-inflammatory drugs and acetaminophen in the treatment of an acute muscle injury.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions; Drug Administration Schedule; Gait; Inflammation; Lactones; Male; Mice; Mice, Inbred C57BL; Models, Animal; Muscle Fibers, Skeletal; Muscle, Skeletal; Organ Size; Regeneration; Sulfones | 2004 |
Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Line; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Activation; Humans; Ibuprofen; Indomethacin; Lactones; Lung; Naproxen; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Sulfones; tert-Butylhydroperoxide; Transcription, Genetic | 2005 |
The effect of analgesic agents on the healing rat medial collateral ligament.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Butorphanol; Collateral Ligaments; Disease Models, Animal; Dose-Response Relationship, Drug; Lactones; Naproxen; Piroxicam; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Sulfones; Weight-Bearing; Wound Healing | 2005 |
Treating pain after Vioxx. Should you switch to another COX-2, a traditional non-steroidal anti-inflammatory, or acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Lactones; Pain; Sulfones | 2005 |
Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Cell Size; Chronic Disease; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Lactones; Male; Neurons, Afferent; Osteoarthritis, Knee; Rats; Sulfones | 2007 |
Trying times for painkiller choices. Vioxx, Bextra, and Celebrex can increase the risk for heart attack and other cardiovascular problems. So can the old standbys, like ibuprofen and acetaminophen.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Isoxazoles; Lactones; Pyrazoles; Risk Assessment; Sulfonamides; Sulfones | 2006 |
Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Prescriptions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Lactones; Male; Myocardial Infarction; Naproxen; Pyrazoles; Quebec; Retrospective Studies; Risk Assessment; Sulfonamides; Sulfones | 2007 |
What happened to the prescribing of other COX-2 inhibitors, paracetamol and non-steroidal anti-inflammatory drugs when rofecoxib was withdrawn in Australia?
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Australia; Cyclooxygenase 2 Inhibitors; Female; Humans; Lactones; Male; Middle Aged; Practice Patterns, Physicians'; Sulfones; Time Factors | 2007 |
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Cyclooxygenase 2 Inhibitors; Female; Focus Groups; Humans; Lactones; Male; Middle Aged; Osteoarthritis; Perception; Practice Patterns, Physicians'; Product Surveillance, Postmarketing; Sulfones | 2009 |
Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Databases, Factual; Female; Humans; Incidence; Isoxazoles; Lactones; Logistic Models; Middle Aged; Odds Ratio; Pyrazoles; Risk; Sulfonamides; Sulfones | 2011 |
Clinical toxicology and drug regulation: a United Kingdom perspective.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipsychotic Agents; Antitussive Agents; Cyclooxygenase 2 Inhibitors; Dextropropoxyphene; Drug Combinations; Drug Overdose; Humans; Lactones; Legislation, Drug; Poison Control Centers; Product Recalls and Withdrawals; Sulfones; Toxicology; United Kingdom | 2011 |