acetaminophen has been researched along with propylene glycol in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gove, CD; Hughes, RD; Williams, R | 1 |
| Loft, S; Poulsen, HE; Roberts, DW; Thomsen, MS | 1 |
| Benson, RW; Leakey, JE; Roberts, DW; Snawder, JE | 1 |
| Beales, D; McLean, AE | 1 |
| Amin, RH; Qian, W; Shichi, H | 1 |
| Jibry, N; Murdan, S; Sarwar, T | 1 |
| Acree, WE; Chan, HK; Chew, NY; Jouyban, A; Khoubnasabjafari, M | 1 |
| Aleksunes, LM; Augustine, LM; Cherrington, NJ; Manautou, JE | 1 |
| Allegaert, K; Danhof, M; De Cock, RF; de Hoon, J; Knibbe, CA; Kulo, A; Verbesselt, R | 1 |
| Böhlke, M; Ganetsky, M; Guatam, S; LeDuc, B; Pereira, L; Salhanick, SD; Williams, D | 1 |
| Jeong, NY; Lee, SY; Oh, SY | 1 |
| Allegaert, K; Danhof, M; De Cock, RF; de Hoon, J; Knibbe, CA; Vanhaesebrouck, S; Verbesselt, R | 1 |
| Berg, AH; Ganetsky, M; Salhanick, S; Solano, JJ | 1 |
2 trial(s) available for acetaminophen and propylene glycol
| Article | Year |
|---|---|
Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chemical and Drug Induced Liver Injury; Cross-Over Studies; Cytochrome P-450 CYP2E1 Inhibitors; Dosage Forms; Excipients; Female; Humans; Male; Propylene Glycol; Sulfates | 2013 |
Inhibition of CYP2E1 With Propylene Glycol Does Not Protect Against Hepatocellular Injury in Human Acetaminophen Daily-Dosing Model.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Interactions; Female; Humans; Male; Propylene Glycol; Young Adult | 2019 |
11 other study(ies) available for acetaminophen and propylene glycol
| Article | Year |
|---|---|
Protective effects of propylene glycol, a solvent used pharmaceutically, against paracetamol-induced liver injury in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Blood Glucose; Drug Antagonism; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Propylene Glycol; Propylene Glycols; Prothrombin Time; Solvents | 1991 |
Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Mice; Mice, Inbred Strains; Oxidoreductases, N-Demethylating; Propylene Glycol; Propylene Glycols | 1995 |
The effect of propylene glycol on the P450-dependent metabolism of acetaminophen and other chemicals in subcellular fractions of mouse liver.
Topics: Acetaminophen; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Liver; Male; Mice; Propylene Glycol; Propylene Glycols; Subcellular Fractions | 1993 |
Cell injury and protection in long-term incubation of liver slices after in vivo initiation with paracetamol: cell injury after in vivo initiation with paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Carnitine; Chromatography, High Pressure Liquid; Fructose; Glutamic Acid; Glycerol; In Vitro Techniques; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Male; Methionine; Phenylenediamines; Potassium; Propylene Glycol; Propylene Glycols; Rats; Rats, Wistar; Time Factors | 1995 |
Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.
Topics: Acetaminophen; Administration, Topical; Animals; Benzoquinones; Cataract; Chromatin; Cilia; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium; Epithelium; Imines; Lens Diseases; Male; Mice; Mice, Inbred DBA; Microscopy, Electron; Mitochondria; Propylene Glycol; Time Factors | 1999 |
Amphiphilogels as drug carriers: effects of drug incorporation on the gel and on the active drug.
Topics: Acetaminophen; Aspirin; Drug Carriers; Ethanol; Gels; Hexoses; Hydrocortisone; Ibuprofen; Polysorbates; Propylene Glycol; Solubility; Solvents; Surface-Active Agents; Temperature | 2006 |
Solubility prediction of paracetamol in binary and ternary solvent mixtures using Jouyban-Acree model.
Topics: Acetaminophen; Ethanol; Models, Chemical; Models, Statistical; Predictive Value of Tests; Propylene Glycol; Solubility; Solvents; Water | 2006 |
Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Gene Expression Regulation; Liver; Male; Mice; Mice, Inbred C57BL; Pharmaceutical Vehicles; Propylene Glycol; RNA, Messenger; Sodium Chloride | 2007 |
Developmental pharmacokinetics of propylene glycol in preterm and term neonates.
Topics: Acetaminophen; Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Models, Biological; Phenobarbital; Pregnancy; Propylene Glycol | 2013 |
Modulation of electroosmosis and flux through skin: effect of propylene glycol.
Topics: Acetaminophen; Animals; Diffusion; Donepezil; Dose-Response Relationship, Drug; Electroosmosis; In Vitro Techniques; Indans; Mice; Piperidines; Propylene Glycol; Skin Absorption; Solubility; Viscosity | 2014 |
Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates.
Topics: Acetaminophen; Computer Simulation; Excipients; Female; Gestational Age; Hepatobiliary Elimination; Humans; Infant, Newborn; Infant, Premature; Male; Models, Biological; Phenobarbital; Propylene Glycol; Renal Elimination | 2014 |