acetaminophen has been researched along with propranolol in 92 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (10.87) | 18.7374 |
| 1990's | 4 (4.35) | 18.2507 |
| 2000's | 33 (35.87) | 29.6817 |
| 2010's | 40 (43.48) | 24.3611 |
| 2020's | 5 (5.43) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Akamatsu, M | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Levine, L | 1 |
| Critchley, EM | 1 |
| Penn, RG | 1 |
| Fox, MJ; Frank, WO; Nambi, P; Palmer, RH; Wetherington, JD | 1 |
| Baraka, OZ; Ford, JM; Roberts, CJ; Truman, CA | 1 |
| Bouchier, IA; Hayes, PC | 1 |
| Mottot, G; Romero-Ferret, C; Rosner, I | 1 |
| Auty, RM; Branch, RA | 1 |
| Dordoni, B; Gazzard, BG; Hughes, RD; Portmann, B; Williams, R | 1 |
| Clark, RA; Holdsworth, CD; Howlett, PJ; Rees, MR | 1 |
| Luczynska, C; Wilson, K | 1 |
| D'Arcy, PF | 1 |
| de Lima, VM; Hanke, W; Wiedemann, M | 1 |
| Kim, SN; Kim, YC; Yoon, MY | 1 |
| Choi, H; Lee, J; Park, TG | 1 |
| Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M | 1 |
| Koumoura, F; Mourouzis, C; Saranteas, T; Tesseromatis, C | 1 |
| Arrivet, E; Bichet, N; Fabre, N; Prenez, A; Roome, NO; Trancard, J; Vericat, JA | 1 |
| Ma, M; Purcell, WM; Xu, J | 2 |
| Franssila, S; Grigoras, K; Huikko, K; Kostiainen, R; Kotiaho, T; Mandel, F; Östman, P; Sauber, C | 1 |
| Bai, SA; Christ, DD; Diamond, S; Grace, JE; Grossman, SJ; He, K; Qian, M; Wong, H; Wright, MR; Yeleswaram, K | 1 |
| Pongjanyakul, T; Priprem, A; Puttipipatkhachorn, S | 1 |
| Abla, N; Geiser, L; Guy, RH; Kalia, YN; Mirgaldi, M; Naik, A; Veuthey, JL | 1 |
| Isawa, K; Kaneko, K; Ono, K; Saito, Y; Seki, A; Yokoyama, A | 1 |
| Jones, OA; Lester, JN; Voulvoulis, N | 1 |
| Kaukonen, AM; Laitinen, L; Marvola, M; Takala, E; Vuorela, H; Vuorela, P | 1 |
| Pongjanyakul, T; Puttipipatkhachorn, S | 1 |
| Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX | 1 |
| Beukers, RJ; Roos, YB | 1 |
| Kertesz, V; Van Berkel, GJ | 1 |
| Frickers, PE; Hutchinson, TH; Readman, JW; Shaw, JP; Solé, M | 1 |
| Khunawattanakul, W; Pongjanyakul, T; Puttipipatkhachorn, S; Rades, T | 2 |
| Chary, NS; Lin, AY; Lin, CA; Tung, HH | 1 |
| Kühne, S; Steinert, M; Untucht, C; Wätzig, H | 1 |
| Balzarini, J; Cabrera, S; Camarasa, MJ; Diez-Torrubia, A; Lambeir, AM; Velázquez, S | 1 |
| Ahmed, S; Alam, MN; Ali, MA; Battacharjee, M; Dey, SK; Israil, A; Miah, AH; Mondal, G; Rahman, KM; Uddin, MJ; Uddin, MS | 1 |
| Arakawa, H; Ikeya, T; Inoue, Y; Iwai, H; Jomura, T; Koeda, A; Kusumoto, K; Nagao, T; Naitoh, K; Ogihara, T; Ohkura, T; Ohta, K; Ozeki, E; Takahashi, N; Ueda, T; Wada, K | 1 |
| Antunes, SC; de Oliveira, LL; Gonçalves, F; Nunes, B; Rocha, O | 1 |
| Antunes, SC; Gonçalves, F; Nunes, B; Oliveira, LL; Rocha, O | 1 |
| Pongjanyakul, T; Rongthong, T; Siepmann, F; Siepmann, J; Sungthongjeen, S | 2 |
| Gangopadhyay, AN; Gupta, DK; Pandey, V; Sharma, SP; Tiwari, P | 1 |
| Chavan, R; Naidu, VGM; Shastri, NR; Thipparaboina, R; Thumuri, D | 1 |
| Costa, MJ; do Carmo, JB; Matus, GN; Nunes, B; Pereira, BVR; Santos, ACAD; Silva-Zacarin, ECM | 1 |
| Fatibello-Filho, O; Santos, AM; Silva, TA; Wong, A | 1 |
| Cordeiro Alves Dos Santos, A; Costa, MJ; Matus, GN; Nunes, B; Pereira, BVR; Silva-Zacarin, ECM | 1 |
| Boncler, M; Dastych, J; Golanski, J; Lukasiak, M; Watala, C | 1 |
| Beck, A; Flockerzi, V; Maurer, HH; Meyer, MR; Richter, LHJ | 1 |
| Abdel-Kawy, HS | 1 |
| Barceló, D; Montemurro, N; Peña-Herrera, JM; Pérez, S | 1 |
| Costa, MJ; de Oliveira Dos Santos, PR; Dos Santos, ACA; Nunes, B; Silva-Zacarín, ECM | 1 |
| Costa, MJ; da Silva-Zacarin, ECM; Dos Santos, ACA; Nunes, B; Pereira, BVR | 1 |
| Badriddinova, LY; Kondratenko, SN; Kovachevich, IV; Polyakov, AV; Repenkova, LG; Savelyeva, MI; Shikh, EV; Svistunov, AA | 1 |
6 review(s) available for acetaminophen and propranolol
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Reported ocular side effects of the ten most frequently prescribed drugs.
Topics: Acetaminophen; Ampicillin; Brompheniramine; Codeine; Diazepam; Digoxin; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Eye; Eye Diseases; Female; Furosemide; Humans; Hydrochlorothiazide; Methyldopa; Phenylephrine; Phenylpropanolamine; Pregnancy; Propranolol; Tetracyclines; Triamterene | 1979 |
The clinical significance of the effects of cigarette smoking on drug disposition.
Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin | 1983 |
Tobacco smoking and drugs: a clinically important interaction?
Topics: Acetaminophen; Animals; Dextropropoxyphene; Drug Interactions; Enzyme Induction; Glutethimide; Humans; Insulin; Lidocaine; Microsomes, Liver; Mixed Function Oxygenases; Pentazocine; Pharmaceutical Preparations; Phenacetin; Phenylbutazone; Propranolol; Smoking; Theophylline | 1984 |
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)].
Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psychology; Child; Flunarizine; GABA Agents; Headache; Humans; Ibuprofen; Metoprolol; Migraine Disorders; Practice Guidelines as Topic; Propranolol; Relaxation Therapy; Serotonin Receptor Agonists; Sumatriptan; Tension-Type Headache; Valproic Acid; Vasodilator Agents | 2002 |
4 trial(s) available for acetaminophen and propranolol
| Article | Year |
|---|---|
The effect of propranolol on paracetamol metabolism in man.
Topics: Acetaminophen; Adult; Antipyrine; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Male; Propranolol | 1990 |
The effect on paracetamol absorption of stimulation and blockade of beta-adrenoceptors.
Topics: Acetaminophen; Adolescent; Adult; Albuterol; Gastric Emptying; Humans; Intestinal Absorption; Isoproterenol; Middle Aged; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1980 |
Efficacy of amitriptyline, pizotifen and propranolol in the prevention of migraine.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Antiemetics; Child; Domperidone; Female; Humans; Male; Middle Aged; Migraine Disorders; Pizotyline; Propranolol; Severity of Illness Index; Time Factors; Treatment Outcome; Vasodilator Agents; Young Adult | 2013 |
Role of propranolol in ulcerated haemangioma of head and neck: a prospective comparative study.
Topics: Acetaminophen; Administration, Oral; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Hemangioma; Humans; Ibuprofen; Infant; Male; Pain Measurement; Propranolol; Prospective Studies; Skin Ulcer; Wound Healing | 2016 |
82 other study(ies) available for acetaminophen and propranolol
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
The diagnosis and management of migraine.
Topics: Acetaminophen; Adult; Analgesics; Antiemetics; Aspirin; Child; Clonidine; Ergotamine; Ergotamines; Female; Humans; Male; Migraine Disorders; Pizotyline; Propranolol | 1978 |
A theoretical approach to the management of paracetamol overdosage.
Topics: Acetaminophen; Charcoal; Cysteamine; Drug Therapy; Glutathione; Humans; Perfusion; Propranolol; Renal Dialysis; Sulfhydryl Compounds | 1976 |
Effects of various concomitant medications on gastric alcohol dehydrogenase and the first-pass metabolism of ethanol.
Topics: Acetaminophen; Adult; Alcohol Dehydrogenase; Animals; Cimetidine; Ethacrynic Acid; Ethanol; Female; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; Nizatidine; Propranolol; Ranitidine; Rats; Reference Values; Salicylates; Salicylic Acid | 1991 |
Effect of acute and chronic propranolol administration on antipyrine and paracetamol clearance in patients with chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Drug Administration Schedule; Female; Humans; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Propranolol | 1989 |
Letter: Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Alprenolol; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Synergism; Mice; Poisoning; Practolol; Propranolol; Xylitol | 1973 |
Letter: Paracetamol toxicity and propranolol.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antagonism; Half-Life; Humans; Liver; Necrosis; Propranolol | 1973 |
Protection of rats against the hepatotoxic effect of paracetamol.
Topics: Acetaminophen; Administration, Oral; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Interactions; Glutathione; Injections, Intraperitoneal; Liver; Male; Microsomes, Liver; Necrosis; Propranolol; Rats; Thioctic Acid; Vitamin E | 1974 |
Effects of antimigraine drugs on retinal spreading depression.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Adrenochrome; Analgesics, Non-Narcotic; Animals; Aspirin; Chickens; Clonidine; Cortical Spreading Depression; Cyclooxygenase Inhibitors; Electrophysiology; Ergotamine; Image Processing, Computer-Assisted; Indolequinones; Lisuride; Methysergide; Migraine Disorders; Neurons; Propranolol; Retina; Serotonin Antagonists; Sumatriptan; Videotape Recording | 1996 |
Potentiation of acetaminophen hepatotoxicity by acute physical exercise in rats.
Topics: Acetaminophen; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Female; Glutathione; Lipid Peroxidation; Liver; Malondialdehyde; Physical Conditioning, Animal; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Time Factors; Vitamin E; Yohimbine | 1997 |
Effect of formulation and processing variables on the characteristics of microspheres for water-soluble drugs prepared by w/o/o double emulsion solvent diffusion method.
Topics: Acetaminophen; Acrylic Resins; Corn Oil; Diffusion; Dose-Response Relationship, Drug; Drug Compounding; Emulsions; Methylene Chloride; Microspheres; Polymethacrylic Acids; Propranolol; Solvents; Surface-Active Agents; Tacrine; Temperature; Theophylline; Water | 2000 |
Effects of propranolol or paracetamol on lidocaine concentrations in serum and tissues.
Topics: Acetaminophen; Administration, Oral; Adrenergic beta-Antagonists; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Drug Interactions; Injections, Intramuscular; Lidocaine; Liver; Male; Mandible; Propranolol; Protein Binding; Rats; Statistics as Topic; Tissue Distribution | 2003 |
A new hepatoma cell line for toxicity testing at repeated doses.
Topics: Acetaminophen; Aspirin; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Perhexiline; Propranolol; Toxicity Tests | 2003 |
Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. I. Glucose metabolism and enzyme release as cytotoxic markers.
Topics: Acetaminophen; Animals; Cell Survival; Diclofenac; Galactosamine; gamma-Glutamyltransferase; Glucose; Hepatocytes; L-Lactate Dehydrogenase; Liver; Male; Models, Biological; Propranolol; Rats; Rats, Sprague-Dawley; Spheroids, Cellular; Toxicity Tests; Xenobiotics | 2003 |
Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. II. Spheroid cell spreading inhibition as a new cytotoxic marker.
Topics: Acetaminophen; Animals; Cell Movement; Cell Survival; Culture Media; Diclofenac; Galactosamine; Hepatocytes; Liver; Male; Propranolol; Rats; Rats, Sprague-Dawley; Spheroids, Cellular; Toxicity Tests; Xenobiotics | 2003 |
Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs.
Topics: Acetaminophen; Air Ionization; Atmospheric Pressure; Carboxylic Acids; Ketoprofen; Mass Spectrometry; Midazolam; Molecular Structure; Naphthaleneacetic Acids; Naphthalenes; Naphthoquinones; Pharmaceutical Preparations; Propranolol; Silicon; Testosterone | 2003 |
The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Non-Narcotic; Animals; Blotting, Western; Bronchodilator Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Models, Biological; Pan troglodytes; Pharmaceutical Preparations; Pharmacokinetics; Propranolol; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Verapamil | 2004 |
Investigation of novel alginate-magnesium aluminum silicate microcomposite films for modified-release tablets.
Topics: Absorption; Acetaminophen; Alginates; Aluminum Compounds; Calorimetry, Differential Scanning; Crystallography, X-Ray; Delayed-Action Preparations; Glucuronic Acid; Hexuronic Acids; Magnesium Compounds; Microscopy, Electron, Scanning; Permeability; Propranolol; Silicates; Spectroscopy, Fourier Transform Infrared; Surface Properties; Tablets; Thermogravimetry; Water | 2005 |
Capillary zone electrophoresis for the estimation of transdermal iontophoretic mobility.
Topics: Acetaminophen; Animals; Dipeptides; Drug Delivery Systems; Electrophoresis, Capillary; In Vitro Techniques; Iontophoresis; Lidocaine; Models, Biological; Molecular Structure; Osmosis; Propranolol; Quinine; Skin; Skin Absorption; Swine | 2005 |
[Effect of propranolol on new daily persistent headache].
Topics: Acetaminophen; Administration, Oral; Adolescent; Child; Drug Therapy, Combination; Female; Headache Disorders; Humans; Indomethacin; Male; Propranolol; Treatment Outcome | 2006 |
The occurrence and removal of selected pharmaceutical compounds in a sewage treatment works utilising activated sludge treatment.
Topics: Acetaminophen; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; England; Environmental Pollutants; Gas Chromatography-Mass Spectrometry; Ibuprofen; Mefenamic Acid; Pharmaceutical Preparations; Propranolol; Sewage; Waste Management | 2007 |
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2).
Topics: Absorption; Acetaminophen; Anthraquinones; Beverages; Caco-2 Cells; Carbon Radioisotopes; Cathartics; Cell Membrane Permeability; Digoxin; Furosemide; Humans; Ketoprofen; Mannitol; Plant Leaves; Propranolol; Senna Extract; Sennosides; Verapamil | 2007 |
Alginate-magnesium aluminum silicate composite films: effect of film thickness on physical characteristics and permeability.
Topics: Acetaminophen; Alginates; Aluminum Compounds; Calorimetry, Differential Scanning; Glucuronic Acid; Hexuronic Acids; Magnesium Compounds; Permeability; Propranolol; Silicates; Technology, Pharmaceutical; Tensile Strength; Thermogravimetry; Water; X-Ray Diffraction | 2008 |
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles | 2008 |
Pontine capillary telangiectasia as visualized on MR imaging causing a clinical picture resembling basilar-type migraine: a case report.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Brain; Central Nervous System Vascular Malformations; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Migraine with Aura; Propranolol; Treatment Outcome; Vasodilator Agents | 2009 |
Application of a liquid extraction based sealing surface sampling probe for mass spectrometric analysis of dried blood spots and mouse whole-body thin tissue sections.
Topics: Acetaminophen; Aminoquinolines; Analgesics, Non-Narcotic; Animals; Blood Specimen Collection; Chromatography, High Pressure Liquid; Frozen Sections; Male; Mass Spectrometry; Mice; Propranolol; Tissue Distribution | 2009 |
Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen.
Topics: Acetaminophen; Animals; Biomarkers; Bivalvia; Carboxylesterase; Catalase; Glutathione Transferase; Propranolol | 2010 |
Chitosan-magnesium aluminum silicate nanocomposite films: physicochemical characterization and drug permeability.
Topics: Acetaminophen; Aluminum Compounds; Aluminum Silicates; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chitosan; Diclofenac; Diffusion; Drug Carriers; Drug Compounding; Hydrogen Bonding; Magnesium; Magnesium Compounds; Nanocomposites; Permeability; Pliability; Powder Diffraction; Propranolol; Silicates; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Tablets; Technology, Pharmaceutical; Temperature; Tensile Strength; Water | 2010 |
Potential for biodegradation and sorption of acetaminophen, caffeine, propranolol and acebutolol in lab-scale aqueous environments.
Topics: Acebutolol; Acetaminophen; Adsorption; Biodegradation, Environmental; Caffeine; Cardiovascular Agents; Central Nervous System Stimulants; Clinical Laboratory Techniques; Environmental Restoration and Remediation; Propranolol; Sensory System Agents; Water Pollutants, Chemical | 2010 |
[Update on current care guidelines; childhood headache].
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Headache; Humans; Ibuprofen; Propranolol; Recurrence; Tryptamines; Vasodilator Agents | 2010 |
Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets.
Topics: Acetaminophen; Aluminum Compounds; Aluminum Silicates; Chitosan; Drug Stability; Excipients; Hydrogen-Ion Concentration; Intestinal Secretions; Magnesium; Magnesium Compounds; Nanocomposites; Propranolol; Silicates; Solubility; Tablets | 2011 |
Fast investigations from biological matrices using CE--test of a blood-brain barrier model.
Topics: Acetaminophen; Adsorption; Animals; Blood-Brain Barrier; Caffeine; Carbamazepine; Cell Culture Techniques; Cell Line; Chromatography, Micellar Electrokinetic Capillary; Cimetidine; Humans; Indomethacin; Limit of Detection; Models, Biological; Propranolol; Rats; Reproducibility of Results; Tissue Distribution | 2012 |
Dipeptidyl peptidase IV (DPPIV/CD26)-based prodrugs of hydroxy-containing drugs.
Topics: Acetaminophen; Amines; Animals; Camptothecin; Cattle; Didanosine; Dipeptides; Dipeptidyl Peptidase 4; Drug Stability; Humans; Hydrolysis; Prodrugs; Propranolol; Solubility; Valine | 2012 |
Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism.
Topics: Acetaminophen; Albuterol; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Diclofenac; Glucuronosyltransferase; Hepatocytes; Humans; Lamotrigine; Midazolam; Pharmaceutical Preparations; Propranolol; Spheroids, Cellular; Tandem Mass Spectrometry; Triazines | 2014 |
Acute and chronic ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna.
Topics: Acetaminophen; Animals; Chlorpromazine; Daphnia; Diclofenac; Dose-Response Relationship, Drug; Female; Propranolol; Rats, Wistar; Reproduction; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical | 2016 |
Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers.
Topics: Acetaminophen; Animals; Biomarkers; Catalase; Chlorpromazine; Daphnia; Diclofenac; Ecotoxicology; Environmental Exposure; Glutathione Peroxidase; Glutathione Transferase; Oxidative Stress; Prescription Drugs; Propranolol | 2015 |
Quaternary polymethacrylate-magnesium aluminum silicate films: Water uptake kinetics and film permeability.
Topics: Acetaminophen; Acrylic Resins; Aluminum Compounds; Aluminum Silicates; Delayed-Action Preparations; Diffusion; Excipients; Hydrogen-Ion Concentration; Kinetics; Magnesium Compounds; Parabens; Permeability; Polymers; Polymethacrylic Acids; Propranolol; Quaternary Ammonium Compounds; Silicates; Solubility; Solutions; Water | 2015 |
Fast dissolving drug-drug eutectics with improved compressibility and synergistic effects.
Topics: Acetaminophen; Animals; Cell Line; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drug Synergism; Etodolac; Humans; Inflammation Mediators; Mice; Powder Diffraction; Propranolol; Solubility; Spectroscopy, Fourier Transform Infrared | 2017 |
Assessment of biochemical alterations in the neotropical fish species Phalloceros harpagos after acute and chronic exposure to the drugs paracetamol and propranolol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antihypertensive Agents; Antipyretics; Biomarkers; Cyprinodontiformes; Dose-Response Relationship, Drug; Female; Male; Propranolol; Water Pollutants, Chemical | 2018 |
Simultaneous determination of isoproterenol, acetaminophen, folic acid, propranolol and caffeine using a sensor platform based on carbon black, graphene oxide, copper nanoparticles and PEDOT:PSS.
Topics: Acetaminophen; Bridged Bicyclo Compounds, Heterocyclic; Caffeine; Copper; Folic Acid; Graphite; Isoproterenol; Metal Nanoparticles; Molecular Structure; Oxides; Particle Size; Polymers; Polystyrenes; Propranolol; Soot | 2018 |
Behavior and histopathology as biomarkers for evaluation of the effects of paracetamol and propranolol in the neotropical fish species Phalloceros harpagos.
Topics: Acetaminophen; Animals; Behavior, Animal; Cyprinodontiformes; Dose-Response Relationship, Drug; Ecotoxicology; Environmental Biomarkers; Female; Glycogen; Liver; Male; Propranolol; Skin Pigmentation; Swimming; Toxicity Tests, Acute; Water Pollutants, Chemical | 2018 |
Differentiated mitochondrial function in mouse 3T3 fibroblasts and human epithelial or endothelial cells in response to chemical exposure.
Topics: 3T3-L1 Cells; A549 Cells; Acetaminophen; Animals; Atropine; Caco-2 Cells; Cell Count; Cell Survival; Cobalt; Endothelial Cells; Ethanol; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Propranolol | 2019 |
Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.
Topics: Acetaminophen; Alkaloids; Biological Assay; Chromatography, Liquid; Fluorescent Dyes; Fluvastatin; Hep G2 Cells; Hepatocytes; Humans; Illicit Drugs; Indans; Indoles; Membrane Potential, Mitochondrial; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Propranolol; Quinolines; Simvastatin; Tandem Mass Spectrometry; Toxicity Tests | 2019 |
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Carvedilol; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Glutathione; Hepatic Stellate Cells; Liver; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Oxidative Stress; Propranolol; Rats, Wistar; Tumor Necrosis Factor-alpha | 2021 |
Development and validation of an analytical method for determination of pharmaceuticals in fish muscle based on QuEChERS extraction and SWATH acquisition using LC-QTOF-MS/MS system.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Food Contamination; Muscles; Propranolol; Salmo salar; Tandem Mass Spectrometry; Venlafaxine Hydrochloride | 2019 |
Neurotoxic and respiratory effects of human use drugs on a Neotropical fish species, Phalloceros harpagos.
Topics: Acetaminophen; Animals; Biomarkers; Cholinesterases; Cyprinodontiformes; L-Lactate Dehydrogenase; Propranolol; Water Pollutants, Chemical; Water Pollution, Chemical | 2020 |
Eudragit RL-based film coatings: How to minimize sticking and adjust drug release using MAS.
Topics: Acetaminophen; Aluminum Compounds; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diclofenac; Drug Liberation; Excipients; Magnesium Compounds; Polymers; Propranolol; Silicates; Tablets; Temperature | 2020 |
Immunodetection of heat shock protein 70 and cell death in liver of a neotropical fish acutely and chronically exposed to acetaminophen and propranolol.
Topics: Acetaminophen; Animals; Cell Death; HSP70 Heat-Shock Proteins; Liver; Propranolol; Water Pollutants, Chemical | 2021 |
Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions.
Topics: Acetaminophen; Furosemide; Humans; Hypokinesia; Pharmaceutical Preparations; Propranolol; Space Flight; Verapamil | 2021 |