acetaminophen and piperine

acetaminophen has been researched along with piperine in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's4 (50.00)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Bharate, SS; Vishwakarma, RA1
Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P1
Cashman, JR; Court, MH; Ghirmai, S; Volak, LP1
Fong, YK; Li, CR; Lin, G; Wang, S; Wo, SK; Zhang, L; Zhou, L; Zuo, Z1
Badmaev, V; Court, MH; Greenblatt, DJ; Hanley, MJ; Harmatz, JS; Hazarika, S; Majeed, M; Masse, G; Volak, LP1
Al Turaifi, FH; El-Daly, M; El-Sheikh, AAK; Mohafez, OM; Morsy, MA; Younis, NS1
Afroze, M; Al-Khafaji, K; Araújo, IM; Asha, UH; Coutinho, HDM; de Lacerda, BCGV; El-Kersh, DM; Islam, MT; Jamaddar, S; Khalipha, ABR; Khan, M; Mondal, M; Moniruzzaman, M; Mori, E; Ray, P; Roy, UK; Sarkar, C; Shill, MC1

Trials

1 trial(s) available for acetaminophen and piperine

ArticleYear
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:2

    Topics: Acetaminophen; Alkaloids; Analgesics, Non-Narcotic; Area Under Curve; Benzodioxoles; Chromatography, High Pressure Liquid; Cross-Over Studies; Curcuma; Curcumin; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Flurbiprofen; Half-Life; Humans; Hypnotics and Sedatives; Midazolam; Piperidines; Plant Extracts; Polyunsaturated Alkamides

2013

Other Studies

7 other study(ies) available for acetaminophen and piperine

ArticleYear
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
    Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7

    Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics

2015
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
    European journal of medicinal chemistry, 2020, Jan-01, Volume: 185

    Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:8

    Topics: Acetaminophen; Alkaloids; Benzodioxoles; Chromatography, High Pressure Liquid; Curcumin; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Liver; Piperidines; Polyunsaturated Alkamides; Recombinant Proteins; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Sulfotransferases

2008
In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein.
    Journal of ethnopharmacology, 2012, Jun-01, Volume: 141, Issue:2

    Topics: Acetaminophen; Administration, Oral; Alkaloids; Animals; Benzodioxoles; Biotransformation; Caco-2 Cells; Catechin; Chromatography, Liquid; Curcumin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavanones; Glucuronides; Herb-Drug Interactions; Humans; Intestinal Absorption; Jejunum; Male; Medicine, Chinese Traditional; Perfusion; Piperidines; Plant Roots; Plants, Medicinal; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Scutellaria baicalensis; Sulfates; Tandem Mass Spectrometry

2012
Protective mechanisms of piperine against acetaminophen-induced hepatotoxicity may be mediated through TGFBRAP1.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:19

    Topics: Acetaminophen; Alkaloids; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Benzodioxoles; Caspase 3; Chemical and Drug Induced Liver Injury; HSP90 Heat-Shock Proteins; Liver; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Transcription Factor RelA

2020
GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study.
    Life sciences, 2022, Nov-15, Volume: 309

    Topics: Acetaminophen; Alkaloids; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Esters; Fatty Acids; Gas Chromatography-Mass Spectrometry; Lipids; Liver; Methanol; Piper; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Serum Albumin; Silymarin

2022