acetaminophen and phenobarbital

acetaminophen has been researched along with phenobarbital in 185 studies

Research

Studies (185)

Timeframe	Studies, this research(%)	All Research%
pre-1990	115 (62.16)	18.7374
1990's	20 (10.81)	18.2507
2000's	31 (16.76)	29.6817
2010's	17 (9.19)	24.3611
2020's	2 (1.08)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A	1
Harner, RS; McDowell, AE; Pardue, HL	1
Richens, A	1
Hinson, JA; Mitchell, JR; Nelson, SD	1
McLean, AE	2
Adamkov, J; Bevilaqua, L; Drobný, M; Fundárek, J; Knéslová, L; Pithová, B; Wolfová, E	1
Harbison, R; Kasantikul, V; Martin, D; Wilson, JT	1
Hart, FE; Willson, RA	2
Shaw, K; Shuster, L; Thompson, ML	1
Streeter, AJ; Timbrell, JA	1
Aarbakke, J	1
Moldéus, P	1
Perucca, E; Richens, A	1
Beaubien, AR; Thomas, BH; Zeitz, W	1
Baty, JD; Robinson, PR	1
Dixon, MF; Kelleher, J; Losowsky, MS; McLachlan, MS; Walker, BE	1
Fiskerstrand, C; Miller, DJ; Pichanick, GG; Saunders, SJ	1
Dybing, E	1
Assandri, A; Perazzi, A	1
Gillette, JR; Mitchell, JR; Snodgrass, WR	1
Day, PA; McLean, AE	1
Gillette, JR	2
Fratter, R; Hickman, R; Miller, DJ; Saunders, SJ; Terblanche, J	1
Awad, JA; Badr, KF; Burk, RF; Kato, T; Morrow, JD; Roberts, LJ; Takahashi, K	1
Brouwer, KL; Studenberg, SD	2
Hasegawa, R; Imaida, K; Ito, N; Shirai, T; Takahashi, S; Yamaguchi, S	1
Bement, WJ; Guzelian, PS; Lambrecht, LK; McCaffrey, J; Park, SS; Schenkman, JB; Sinclair, JF; Sinclair, PR; Smith, EL; Wood, SG	1
Burk, RF; Hill, KE; Hunt, RW; Martin, AE	1
Kalhorn, TF; Lee, CA; Nelson, SD; Slattery, JT	1
Brouwer, KL; Jones, JA	1
Brunelleschi, S; Conti, A; Fantozzi, R; Lodovici, M; Mannaioni, PF; Masini, E	1
Ignarro, LJ; Wood, KS	1
Lutz, W; Sułkowski, W	1
De Vries, J; Groot, EJ; van Bree, L	1
Bartolone, JB; Birge, RB; Cohen, SD; Khairallah, EA; Mangold, JB; McCann, DJ	1
McLean, AE; Mourelle, M	1
Gregus, Z; Klaassen, CD; Madhu, C	1
Clerc, JT; Kosmeas, N	1
Waalkes, MP; Ward, JM	1
Marzella, L; Muhvich, K; Myers, RA	1
Ash, SR; Kaufman, G; Peck, GE; Shihab-Eldeen, AA	1
Armstrong, GR; Beales, D; McLean, AE	1
Hughes, H; Mitchell, JR; Smith, CV; Tsokos-Kuhn, JO	1
de Vries, J; Redegeld, FA; van Bree, L	1
Farber, JL; Kyle, ME; Nakae, D; Serroni, A	1
Axworthy, DB; Baillie, TA; Calleman, CJ; Hoffmann, KJ; Pascoe, GA; Streeter, AJ	1
Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM	1
D'Ver, AS; Ecobichon, DJ; Ehrhart, W	1
Furukawa, F; Hasegawa, R; Hayashi, Y; Jang, JJ; Sato, S; Takahashi, M; Toyoda, K; Yamashita, K	1
Avaria, M; Basu, PK; Lubek, BM; Wells, PG	1
Bauer, M; Bauerová, J; Bojar, Z; Dobrotka, G; Marsinová, G	1
Driver, HE; McDanell, R; McLean, AE; Tacchi-Bedford, AM	1
Lupo, S; Mico, BA; Rush, GF; Yodis, LA	1
Blouin, RA; Cibull, M; Dickson, P; McClain, C; McNamara, PJ	1
Ahmed, AE; Douidar, SM	1
Bien, E; Witt, M	1
Opheim, KE; Raisys, VA	1
Gallanosa, AG; Spyker, DA	1
Atkins, LM; Fody, EP; Gale, GR; Smith, AB; Walker, EM	1
Cefalo, RC; Isenhower, WD; Korach, KS; McLachlan, JA; Newbold, RR	1
Lerche, A; Pedersen, NT; Poulsen, HE	1
Gershbein, LL; White, AC	1
Loeser, W; Siegers, CP	1
Siegers, CP; Younes, M	2
Jatlow, P	1
Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ	3
Kampffmeyer, HG	4
Büch, H; Eschrich, C; Pfleger, K; Rummel, W; Texter, N	1
Ganshorn, A; Kurz, H	1
Beyrich, T; Schleuder, M	1
Chatfield, DH; Morton, DM	1
Röttger, HJ; Windorfer, A	1
Ballinger, BR; Simpson, E; Stewart, MJ	1
Jollow, DJ; Keiser, H; Mitchell, JR; Potter, WZ; Thorgeirsson, SS	1
Jollow, DJ; Mitchell, JR; Potter, WZ; Thorgeirsson, SS	1
Hashimoto, M; Jollow, DJ; Mitchell, JR; Potter, WZ; Thorgeirsson, SS	1
Coper, H	1
Prescott, LF; Wrights, N	1
Dixon, MF; Kelleher, J; Losowsky, MS; Walker, BE	1
Blake, MI; Hunt, J; Rhodes, HJ	1
Knepil, J	1
Windorfer, A	1
Cryer, PE; Sode, J	1
Sharley, CB	1
LeValley, SE; Mitoma, C	1
Meloff, K	1
Ertel, IJ; Levy, G	1
Ibrahim, I; Sulman, FG; Weller, CP	1
Guillory, JK; Hwang, SC; Lach, JL	1
Carrière, F; Coignet, J; Richez, P	1
Bour, H	1
B4uch, H; Gerhards, W; Pfleger, K; Rüdiger, W; Rummel, W	1
Kobayashi, M; Nagashima, H; Nakatsukasa, H; Watanabe, A	1
De Vries, J; Jansen, JD; Kroese, ED; Van Bree, L; Van Ginneken, CA	1
Bhatia, A; Das, PK; Sharma, S	1
Pirotte, JH	1
Jess, U; Siegers, CP; Younes, M	1
Baillie, TA; Dahlin, DC; Nelson, SD; Streeter, AJ	1
Anundi, I; Dawson, JR; Moldéus, P; Norbeck, K	1
Battershill, JM; Gibson, GG; Ioannides, C; Masson, HA; Steele, CM	1
McLean, AE; Tame, D; Witts, DJ	1
Goldberg, DM	1
Pflüger, KH	1
Crome, P; Helliwell, M; Raper, S; Vale, A; Widdop, B	1
Massey, TE; McElligott, TF; Racz, WJ; Walker, RM	1
Devalia, JL; McLean, AE; Ogilvie, RC	1
Maier-Lenz, H; Ringwelski, L; Windorfer, A	1
Gaylor, JD; Radcliffe, DF	1
Gergely, V; Moldéus, P	1
Bolanowska, W; Gessner, T	1
Jensen, NM; Nebert, DW; Shichi, H; Tanaka, M	1
Batt, AM; Benhamou, JP; Cobert, B; Degott, C; Level, R; Martin, N; Pessayre, D; Wandscheer, JC	1
Kaa, E	1
Crankshaw, D; Reicks, MM	1
Blouin, RA; Chaudhary, IP; Cibull, M; Robertson, LW; Tuntaterdtum, S	1
Jaw, S; Jeffery, EH	1
Blouin, RA; Chaudhary, IP; McNamara, PJ; Robertson, LW; Tuntaterdtum, S	1
Martin, FL; McLean, AE	2
Hanzlick, R	1
Kawai, Y; Mabuchi, M; Nitoh, S; Noguchi, M	1
Hershkovitz, E; Levitas, A; Shorer, Z; Tal, A	1
Abbott, FS; Farrell, K; Tabatabaei, AR; Thies, RL	1
Maier, P; Milosevic, N; Schawalder, H	1
Galchev, V; Kindt, E; Kostrubsky, VE; Ramachandran, V; Rose, K; Sinclair, JF; Sinz, M; Strom, SC; Venkataramanan, R; Wen, YH	1
Baratto, L; Farinelli, G; Monteforte, P; Rovetta, G	1
Brouwer, KL; Meier, PJ; Pollack, GM; Sugiyama, Y; Suzuki, H; Xiong, H	1
Hodgson, HJ; Rahman, TM; Selden, AC	1
Marx, J	1
Chua, SS; Huang, W; Moore, DD; Wei, P; Zhang, J	1
Agbaba, D; Aleksic, M; Eric, S; Franeta, JT; Pavkov, S; Vladimirov, S	1
Cherrington, NJ; Klaassen, CD; Maher, JM; Slitt, AL	1
Han, J; He, P; Li, XD; Lv, Y; Wu, MC; Xia, SQ	1
KRISCHEK, J	1
Rumack, BH	1
Heath, DA; Wilding, P	1
Kostrubsky, SE; Kulkarni, S; Mutlib, A; Sinclair, JF; Stolz, DB; Strom, SC; Urda, E; Wen, YH; Wood, S	1
Adler, R; Amacher, DE; Herath, A; Townsend, RR	1
Abdel-Sattar, E; Ali Hasan, AG; Hamamy, MI; Mohamed, AF	1
Fujisawa, M; Hirose, Y; Hori, Y; Shimada, K; Yoshioka, T	1
Ahmed, MR; Guo, D; Jia, Y; Reddy, JK; Sambasiva Rao, M; Sarkar, J; Viswakarma, N; Yu, S	1
Azikuri, GSh; Lazrishvili, IL; Mitagvariia, NP; Sarishvili, AG; Tsintsadze, TG	1
Ahmed, MR; Guo, D; Jia, Y; Qi, C; Rao, MS; Reddy, JK; Sarkar, J; Usuda, N; Viswakarma, N	1
Fukuyama, T; Ikari, A; Ikushiro, S; Miwa, M; Osabe, M; Sugatani, J	1
Galanopoulou, P; Konstandi, M; Lang, MA; Liapi, C; Marselos, M; Segos, D; Theocharis, S; Zarros, A	1
Ando, Y; Kiyosawa, N; Manabe, S; Niino, N; Watanabe, K; Yamoto, T	1
Braun, B; Reber, M	1
Alder, J; Bjerrum, OJ; Brian Houston, J; Garner, C; Gesson, C; Grynkiewicz, G; Jochemsen, R; Lappin, G; Oosterhuis, B; Rowland, M; Shishikura, Y; Weaver, RJ	1
Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T	1
Baghayeri, M; Ojani, R; Raoof, JB	1
Allegaert, K; Danhof, M; De Cock, RF; de Hoon, J; Knibbe, CA; Kulo, A; Verbesselt, R	1
Braeuning, A; Pichler, BJ; Schmid, A; Schwarz, M; Singh, Y	1
Allegaert, K; Danhof, M; De Cock, RF; de Hoon, J; Knibbe, CA; Vanhaesebrouck, S; Verbesselt, R	1
Hayashi, H; Kanki, M; Minami, K; Mitsumori, K; Morikawa, Y; Omura, K; Ono, A; Uehara, T; Urushidani, T; Yamada, H	1
Katoh, M; Kondo, Y; Nadai, M; Sakakibara, Y	1
Andersen, ME; Cowie, DE; Deisenroth, C; LeCluyse, E; Peffer, RC; Soldatow, V; Trask, OJ	1
Banzi, R; Bruschettini, M; Calevo, MG; Ley, D; Paraskevas, T; Romantsik, O; Stróżyk, A	1

Reviews

11 review(s) available for acetaminophen and phenobarbital

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interactions with antiepileptic drugs. Drugs, 1977, Volume: 13, Issue:4 Topics: Acetaminophen; Acetazolamide; Anti-Anxiety Agents; Anticoagulants; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Furosemide; Gonadal Steroid Hormones; Griseofulvin; Humans; Phenobarbital; Phenytoin; Primidone; Thiazines; Urea; Valproic Acid; Vitamin D	1977
Death in an adolescent following an overdose of acetaminophen and phenobarbital. American journal of diseases of children (1960), 1978, Volume: 132, Issue:5 Topics: Acetaminophen; Adolescent; Animals; Brain; Child; Diagnosis, Differential; Female; Gastric Lavage; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Methionine; Phenobarbital; Prognosis; Risk; Suicide; Sulfhydryl Compounds	1978
[Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis]. Postepy higieny i medycyny doswiadczalnej, 1989, Volume: 43, Issue:5-6 Topics: Acetaminophen; Cytochrome P-450 CYP1A2; Cytochromes; Free Radicals; Humans; Hydroxylation; Mixed Function Oxygenases; Neoplasms; Phenobarbital; Polycyclic Compounds	1989
The influence of diet on activation and inactivation of chemicals--evidence from animals and man. Developments in toxicology and environmental science, 1986, Volume: 12 Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Colonic Neoplasms; Cytochrome P-450 Enzyme System; Diet; Dietary Proteins; Dimethylhydrazines; Enzyme Induction; Epilepsy; Glutathione; Humans; Liver; Liver Neoplasms; Phenobarbital	1986
Therapeutic drug monitoring in pediatric acute drug intoxications. Therapeutic drug monitoring, 1985, Volume: 7, Issue:2 Topics: Acetaminophen; Alcoholic Intoxication; Antidepressive Agents, Tricyclic; Child; Humans; Iron; Kinetics; Monitoring, Physiologic; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Poisoning; Salicylates; Salicylic Acid; Theophylline	1985
Sulindac hepatotoxicity: a case report and review. Journal of toxicology. Clinical toxicology, 1985, Volume: 23, Issue:2-3 Topics: Acetaminophen; Adolescent; Adult; Aged; Animals; Child; Drug Interactions; Enzyme Induction; Ethanol; Female; Humans; Indenes; Liver; Male; Middle Aged; Phenobarbital; Phenytoin; Propionates; Sulindac	1985
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry. Clinical chemistry, 1980, Volume: 26, Issue:6 Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; Energy Intake; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Smoking; Tolbutamide; Warfarin	1980
Acetaminophen misconceptions. Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:1 Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Drug Interactions; Humans; Liver; Phenobarbital; Phenytoin	2004
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews. The Cochrane database of systematic reviews, 2023, 08-11, Volume: 8 Topics: Acetaminophen; Analgesics, Opioid; Cerebral Hemorrhage; Female; Heroin; Humans; Ibuprofen; Infant, Newborn; Infant, Premature; Midazolam; Pain; Perinatal Death; Phenobarbital; Respiration, Artificial; Systematic Reviews as Topic	2023

Trials

4 trial(s) available for acetaminophen and phenobarbital

Article	Year
[Effectiveness of fenalgin SPOFA in lumboischiadic syndrome (author's transl)]. Bratislavske lekarske listy, 1979, Volume: 71, Issue:4 Topics: Acetaminophen; Adult; Aspirin; Back Pain; Caffeine; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Drug Combinations; Female; Humans; Male; Middle Aged; Phenobarbital; Sciatica; Syndrome	1979
Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs. British journal of clinical pharmacology, 1979, Volume: 7, Issue:2 Topics: Acetaminophen; Administration, Oral; Adult; Anticonvulsants; Biological Availability; Carbamazepine; Female; Humans; Injections, Intravenous; Male; Phenobarbital; Phenytoin; Primidone	1979
[Biological half-life of phenacetin and phenazone in man before and after treatment with phenobarbital]. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4 Topics: Acetaminophen; Antipyrine; Clinical Trials as Topic; Half-Life; Humans; Male; Phenacetin; Phenobarbital	1970
Failure to detect increased elimination rate of phenacetin in man after treatment with phenobarbital. Klinische Wochenschrift, 1969, Nov-15, Volume: 47, Issue:22 Topics: Acetaminophen; Adult; Antipyrine; Humans; Male; Phenacetin; Phenobarbital; Time Factors	1969

Other Studies

170 other study(ies) available for acetaminophen and phenobarbital

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity. Bioorganic & medicinal chemistry letters, 2021, 10-01, Volume: 49 Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines	2021
Application of a vidicon spectrometer for simultaneous multicomponent drug determinations. Clinical chemistry, 1976, Volume: 22, Issue:11 Topics: Acetaminophen; Aminophylline; Barbiturates; Computers; Humans; Pharmaceutical Preparations; Phenobarbital; Phenylbutazone; Phenytoin; Procainamide; Regression Analysis; Salicylamides; Secobarbital; Spectrophotometry, Ultraviolet; Time Factors	1976
Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin. Molecular pharmacology, 1977, Volume: 13, Issue:4 Topics: Acetaminophen; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Isotopes; Phenacetin; Phenobarbital	1977
Hazards from chemicals: scientific questions and conflicts of interest. Proceedings of the Royal Society of London. Series B, Biological sciences, 1979, Jul-18, Volume: 205, Issue:1158 Topics: Acetaminophen; Adult; Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Environmental Pollutants; Environmental Pollution; Female; Humans; Industry; Infant Mortality; Infant, Newborn; Liver; Male; Middle Aged; Mortality; Phenobarbital; Rats; Risk; Social Responsibility; United Kingdom	1979
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. Research communications in chemical pathology and pharmacology, 1977, Volume: 16, Issue:1 Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Liver; Liver Diseases; Male; Microsomes, Liver; Necrosis; Phenobarbital; Rats; Time Factors	1977
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism. Biochemical pharmacology, 1979, Aug-01, Volume: 28, Issue:15 Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine; Male; Mice; Mice, Inbred Strains; Necrosis; Phenobarbital; Proadifen; Sleep	1979
The effect of dichloralphenazone pretreatment on paracetamol hepatotoxicity in mice. Biochemical pharmacology, 1979, Oct-01, Volume: 28, Issue:19 Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Cytochrome P-450 Enzyme System; Glutathione; Male; Mice; Mice, Inbred BALB C; Organ Size; Phenobarbital	1979
Nutrition and the intracellular site of toxic injury. World review of nutrition and dietetics, 1978, Volume: 29 Topics: Acetaminophen; Animals; Catechin; Cytochrome P-450 Enzyme System; Glutathione; Humans; Isocitrate Dehydrogenase; Liver; Nutritional Physiological Phenomena; Phenobarbital; Rats	1978
Impaired oxidation of antipyrine in stagnant loop rats. Scandinavian journal of gastroenterology, 1977, Volume: 12, Issue:8 Topics: Acetaminophen; Animals; Antipyrine; Biotransformation; Blind Loop Syndrome; Half-Life; Lincomycin; Liver; Male; Phenobarbital; Rats	1977
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochemical pharmacology, 1978, Volume: 27, Issue:24 Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glucuronates; Glutathione; In Vitro Techniques; Liver; Male; Mice; Phenobarbital; Rats; Sulfates; Time Factors	1978
Effect of subacute dosing and phenobarbital and 3-methylcholanthrene pretreatment on the metabolism of acetaminophen in rats. Canadian journal of physiology and pharmacology, 1977, Volume: 55, Issue:1 Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Phenobarbital; Premedication; Rats	1977
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury. Research communications in chemical pathology and pharmacology, 1977, Volume: 17, Issue:4 Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Induction; Glutathione; In Vitro Techniques; Liver Diseases; Male; Methionine; Microsomes, Liver; Phenobarbital; Rats; Solvents	1977
Production in vitro of paracetamol from phenacetin and [2H]acetanilide: a study with stable isotopes [proceedings]. Biochemical Society transactions, 1977, Volume: 5, Issue:5 Topics: Acetaminophen; Acetanilides; Animals; Deuterium; Isotope Labeling; Liver; Male; Phenacetin; Phenobarbital; Rats	1977
Portal venous infusion of paracetamol and antipyrine in the rat. Pharmacological research communications, 1977, Volume: 9, Issue:8 Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Injections, Intravenous; Male; Phenobarbital; Portal Vein; Rats; Spleen	1977
Experimental liver necrosis: hepatic erythrocyte sequestration as a cause of acute anemia. The American journal of digestive diseases, 1977, Volume: 22, Issue:12 Topics: Acetaminophen; Acute Disease; Anemia; Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; Glutathione; Hematocrit; Liver; Male; Organ Size; Phenobarbital; Prospective Studies; Swine	1977
Inhibition of acetaminophen glucuronidation by oxazepam. Biochemical pharmacology, 1976, Jun-15, Volume: 25, Issue:12 Topics: Acetaminophen; Animals; Cell Line; Cytochrome P-450 Enzyme System; Depression, Chemical; Flavonoids; Glucuronates; In Vitro Techniques; Kinetics; Male; Mice; Microsomes, Liver; Oxazepam; Phenobarbital; Rats	1976
Competition between diftalone and other drugs for the binding site(s) on human serum albumin. Medical biology, 1976, Volume: 54, Issue:3 Topics: Acetaminophen; Aspirin; Binding Sites; Dexamethasone; Drug Interactions; Humans; Indomethacin; Phenobarbital; Phenylbutazone; Phthalazines; Protein Binding; Pyridazines; Serum Albumin; Temperature; Tolbutamide; Warfarin	1976
The role of biotransformation in chemical-induced liver injury. Environmental health perspectives, 1976, Volume: 15 Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cricetinae; Furosemide; Glutathione; Guinea Pigs; Humans; In Vitro Techniques; Iproniazid; Isoniazid; Liver Diseases; Methylcholanthrene; Mice; Phenobarbital; Rats	1976
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures. Biochemical pharmacology, 1975, Jan-01, Volume: 24, Issue:1 Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 Enzyme System; Dietary Proteins; Drug Combinations; Fasting; Glutathione; Lethal Dose 50; Liver; Male; Methionine; Necrosis; Oils; Phenobarbital; Rats; Selenium; Yeast, Dried	1975
Environmental factors in drug metabolism. Federation proceedings, 1976, Volume: 35, Issue:5 Topics: Acetaminophen; Animals; Azo Compounds; Biotransformation; Cytochrome P-450 Enzyme System; Environment; Enzyme Induction; Intestinal Mucosa; Methylcholanthrene; Microsomes, Liver; Phenobarbital	1976
An animal model of fulminant hepatic failure: a feasibility study. Gastroenterology, 1976, Volume: 71, Issue:1 Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Hepatic Encephalopathy; Liver; Male; Phenobarbital; Swine	1976
Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. The Journal of clinical investigation, 1992, Volume: 90, Issue:6 Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Indomethacin; Isoniazid; Lipid Peroxides; Male; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Thioacetamide	1992
Impaired biliary excretion of acetaminophen glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo phenobarbital pretreatment. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3 Topics: Acetaminophen; Animals; Biliary Tract; Chromatography, High Pressure Liquid; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1992
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine. Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:3 Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344	1991
Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes. Archives of biochemistry and biophysics, 1991, Feb-01, Volume: 284, Issue:2 Topics: Acetaminophen; Animals; Cells, Cultured; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Ethanol; Hydroxylation; Liver; Male; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin	1991
Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it. Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Glutathione; Isoniazid; Liver; Male; Phenobarbital; Pyrazoles; Rats; Rats, Inbred F344	1990
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline	1990
Altered hepatobiliary disposition of acetaminophen metabolites after phenobarbital pretreatment and renal ligation: evidence for impaired biliary excretion and a diffusional barrier. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:2 Topics: Acetaminophen; Animals; Bile; Bile Ducts; Diffusion; Kidney; Ligation; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1990
Histamine release by free radicals: paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase. Agents and actions, 1986, Volume: 18, Issue:1-2 Topics: Acetaminophen; Animals; Enzyme Induction; Exocytosis; Free Radicals; Histamine Release; In Vitro Techniques; Male; Mast Cells; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1986
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase. The Journal of biological chemistry, 1987, Apr-15, Volume: 262, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine	1987
Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4'-dichlorobiphenyl, phenobarbitone and pregnenolone-16-alpha-carbonitrile. The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:5 Topics: Acetaminophen; Animals; Aspirin; Cytochrome P-450 Enzyme System; Enzyme Induction; Gastric Mucosa; Glutathione; In Vitro Techniques; Liver; Male; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Salicylates	1989
Selective protein arylation by acetaminophen and 2,6-dimethylacetaminophen in cultured hepatocytes from phenobarbital-induced and uninduced mice. Relationship to cytotoxicity. Biochemical pharmacology, 1989, Dec-15, Volume: 38, Issue:24 Topics: Acetaminophen; Animals; Antibody Specificity; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Liver; Male; Mice; Phenobarbital; Proteins	1989
Electron transport and protection of liver slices in the late stage of paracetamol injury of the liver. British journal of pharmacology, 1989, Volume: 98 Suppl Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Transport; In Vitro Techniques; Liver; Phenobarbital; Rats	1989
Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: effect of chemicals that alter acetaminophen hepatotoxicity. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Acetaminophen; Animals; Antioxidants; Bile; Biotransformation; Cricetinae; Cysteamine; Liver; Male; Mesocricetus; Methylcholanthrene; Phenobarbital; Prostaglandin Antagonists	1989
[A quick DC method for simultaneous quantitative determination of paracetamol, caffeine, phenobarbital and propyphenazone in plasma]. Pharmaceutica acta Helvetiae, 1989, Volume: 64, Issue:1 Topics: Acetaminophen; Antipyrine; Caffeine; Humans; Phenobarbital	1989
Induction of hepatic metallothionein in male B6C3F1 mice exposed to hepatic tumor promoters: effects of phenobarbital, acetaminophen, sodium barbital, and di(2-ethylhexyl) phthalate. Toxicology and applied pharmacology, 1989, Sep-01, Volume: 100, Issue:2 Topics: Acetaminophen; Animals; Barbital; Cadmium; Carcinogens; Chromatography, Gel; Cytosol; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Liver; Male; Metallothionein; Mice; Phenobarbital; Phthalic Acids; Zinc	1989
Effect of hyperoxia on liver necrosis induced by hepatotoxins. Virchows Archiv. B, Cell pathology including molecular pathology, 1986, Volume: 51, Issue:6 Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cricetinae; Hyperbaric Oxygenation; Liver; Liver Diseases; Male; Mesocricetus; Necrosis; Phenobarbital; Poisoning; Rats; Rats, Inbred Strains	1986
Evaluation of the sorbent suspension reciprocating dialyser in the treatment of overdose of paracetamol and phenobarbitone. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Dogs; Evaluation Studies as Topic; Half-Life; Phenobarbital; Renal Dialysis	1988
Effect of D- or L-methionine and cysteine on the growth inhibitory effects of feeding 1% paracetamol to rats. Biochemical pharmacology, 1989, Jan-15, Volume: 38, Issue:2 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Growth; Methionine; Phenobarbital; Rats; Sulfates	1989
Alkylating toxins and the liver plasma membrane calcium pump/calcium atpase. Advances in experimental medicine and biology, 1988, Volume: 232 Topics: Acetaminophen; Animals; Bromobenzenes; Calcium; Calcium-Transporting ATPases; Carbon Tetrachloride; Cell Membrane; Homeostasis; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains	1988
The 3-methylcholanthrene-mimetic effect of 4,4'-dichlorobiphenyl-treatment on phenacetin-induced hepatic glutathione depletion and liver microsomal phenacetin O-deethylation in rats. Toxicology, 1986, Dec-15, Volume: 42, Issue:2-3 Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Glutathione; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenacetin; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains	1986
1,3-(2-Chloroethyl)-1-nitrosourea potentiates the toxicity of acetaminophen both in the phenobarbital-induced rat and in hepatocytes cultured from such animals. Molecular pharmacology, 1988, Volume: 34, Issue:4 Topics: Acetaminophen; Acetone; Carmustine; Cell Survival; Deferoxamine; Drug Synergism; Enzyme Induction; Glutathione; Liver; Male; Maleates; Methylcholanthrene; Phenobarbital; Phenylenediamines	1988
Covalent binding of acetaminophen to mouse hemoglobin. Identification of major and minor adducts formed in vivo and implications for the nature of the arylating metabolites. Chemico-biological interactions, 1988, Volume: 68, Issue:1-2 Topics: Acetaminophen; Acetylation; Animals; Binding Sites; Chromatography, High Pressure Liquid; Hemoglobins; Hydrogen-Ion Concentration; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Phenobarbital	1988
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car Toxicology and applied pharmacology, 1988, Volume: 96, Issue:3 Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immunohistochemistry; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Phenobarbital; Phthalic Acids; Thymidine Kinase	1988
Drug disposition and biotransformation in the developing beagle dog. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1988, Volume: 11, Issue:1 Topics: Acetaminophen; Aging; Animals; Biotransformation; Blood Proteins; Dogs; Female; Half-Life; Male; Pharmacokinetics; Phenobarbital; Phenytoin; Protein Binding; Ultrafiltration	1988
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats. Carcinogenesis, 1988, Volume: 9, Issue:5 Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344	1988
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1988, Volume: 10, Issue:4 Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Rabbits	1988
[Significance of the interaction between analgesic-antipyretics and ethanol in forensic medicine investigations]. Bratislavske lekarske listy, 1987, Volume: 87, Issue:4 Topics: Accidents, Traffic; Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Codeine; Drug Combinations; Drug Interactions; Ethanol; Forensic Medicine; Guaifenesin; Humans; Male; Middle Aged; Phenobarbital; Psychomotor Performance	1987
In vivo and in vitro hepatotoxicity and metabolism of acetaminophen in Syrian hamsters. Toxicology, 1987, Volume: 44, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Animals; Chromatography, High Pressure Liquid; Cricetinae; Enzyme Induction; In Vitro Techniques; Kinetics; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Male; Mesocricetus; Methylcholanthrene; Phenobarbital	1987
Phenobarbital induction and acetaminophen hepatotoxicity: resistance in the obese Zucker rodent. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2 Topics: Acetaminophen; Animals; Enzyme Induction; Glutathione; Liver; Obesity; Phenobarbital; Rats; Rats, Zucker	1987
A novel mechanism for the enhancement of acetaminophen hepatotoxicity by phenobarbital. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2 Topics: Acetaminophen; Biotransformation; Cell Compartmentation; Cytochrome P-450 Enzyme System; Drug Synergism; Glucuronates; Glucuronic Acid; Glutathione; Liver; Microsomes, Liver; Phenobarbital	1987
Influence of pyrazolones on hepatic glutathione in rats. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1985, Volume: 8 Topics: 1-Propanol; Acetaminophen; Aminopyrine; Animals; Antipyrine; Carbon Tetrachloride; Cobalt; Female; Glutathione; Liver; Phenobarbital; Propanols; Pyrazoles; Rats; Rats, Inbred Strains; Thioacetamide	1985
Effects of acetaminophen on cadmium metabolism in mice. Toxicology and applied pharmacology, 1986, Volume: 82, Issue:2 Topics: Acetaminophen; Animals; Body Burden; Cadmium; Chromatography, Gel; Cysteine; Feces; Kidney; Liver; Male; Metallothionein; Mice; Phenobarbital	1986
Absence of estrogenic activity in some drugs commonly used during pregnancy. Biological research in pregnancy and perinatology, 1986, Volume: 7, Issue:1 Topics: Acetaminophen; Animals; Diethylstilbestrol; Dose-Response Relationship, Drug; Estrogens; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Organ Size; Phenobarbital; Pregnancy; Pregnancy, Animal; Receptors, Estrogen; Saccharin; Uterus	1986
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. Pharmacology, 1985, Volume: 30, Issue:2 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver Diseases; Necrosis; Nitroanisole O-Demethylase; Phenobarbital; Prothrombin Time; Rats; Rats, Inbred Strains; Time Factors	1985
Liver regeneration and hepatic microsomal enzyme induction by acetaminophen and derivatives. Research communications in chemical pathology and pharmacology, 1985, Volume: 48, Issue:2 Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver Regeneration; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Structure-Activity Relationship	1985
Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats. Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 275, Issue:2 Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glucuronates; Glutathione; Ketones; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Sulfates	1985
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity. Chemico-biological interactions, 1985, Volume: 55, Issue:3 Topics: Acetaminophen; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Deferoxamine; Enzyme Induction; Ethane; Iron; Lipid Peroxides; Male; Mice; Phenobarbital; Rats; Rats, Inbred Strains	1985
Ultraviolet spectrophotometric analysis of barbiturates: evaluation of potential interferences. American journal of clinical pathology, 1973, Volume: 59, Issue:2 Topics: Acetaminophen; Barbiturates; Chlorothiazide; Chlorpropamide; Dicumarol; Humans; Methods; Nicotinic Acids; Oxyphenbutazone; Phenacetin; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Salicylates; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Sulfinpyrazone; Sulfisoxazole; Theobromine; Theophylline; Warfarin	1973
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium	1973
Metabolic rate of phenacetin and of paracetamol in dogs before and after treatment with phenobarbital or skf 525 A. Biochemical pharmacology, 1974, Feb-01, Volume: 23, Issue:3 Topics: Acetaminophen; Animals; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dealkylation; Dialysis; Dogs; Half-Life; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Phenacetin; Phenazines; Phenobarbital; Proadifen; Proteins	1974
[Urinary excretion of free and conjugated sulfate following administration of N-acetyl-p-aminophenol in rats and men]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 259, Issue:3 Topics: Acetaminophen; Animals; Female; Humans; Male; Phenobarbital; Rats; Sodium; Sulfates; Thiosulfates	1968
[Differences between the protein binding of newborns and adults and their importance for pharmacological action]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2 Topics: Acetaminophen; Age Factors; Aminosalicylic Acids; Atropine; Chloramphenicol; Humans; Infant, Newborn; Isoniazid; Methicillin; Morphine; Nitrofurantoin; Oxyphenbutazone; Phenacetin; Phenobarbital; Phenytoin; Promethazine; Protein Binding; Salicylates; Sulfadimethoxine; Thiopental	1968
Hydroxylation of phenacetin by beagle liver microsomes. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 286, Issue:3 Topics: Acetaminophen; Animals; Benzopyrenes; Dealkylation; Dogs; Hydroxylation; Kinetics; Microsomes, Liver; Phenacetin; Phenobarbital; Proadifen	1974
[Comparative study on quantitative determination of mixtures of analgesics. 1. Studies on selectivity of volumetric analysis procedures]. Die Pharmazie, 1974, Volume: 29, Issue:7 Topics: Acetaminophen; Aminopyrine; Analgesics; Ascorbic Acid; Aspirin; Barbiturates; Caffeine; Chlorpromazine; Codeine; Conductometry; Electrochemistry; Meprobamate; Mesylates; Methods; Papaverine; Phenacetin; Phenobarbital; Phenylbutazone; Potentiometry; Quinine; Salicylamides; Salicylates; Theobromine	1974
The effects of adjuvant-induced arthritis on the liver metabolism of drugs in rats. Biochemical pharmacology, 1970, Volume: 19, Issue:2 Topics: Acetaminophen; Adjuvants, Immunologic; Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis; Biological Transport, Active; Blood Proteins; Cholesterol; Cytochromes; Electrons; Glucose-6-Phosphatase; Glucuronates; Histocytochemistry; In Vitro Techniques; Liver Glycogen; Lymph Nodes; Male; Microsomes, Liver; Mycobacterium tuberculosis; NADP; Oxidoreductases; Phenobarbital; Rats; RNA; Serum Albumin; Succinate Dehydrogenase	1970
[Micro-method for the quantitative determination of sedatives and antipyretics (aminophenazone, diphenylhydantoin, paracetamol, phenobarbital, primidone) using thermo-gas chromatography]. Arzneimittel-Forschung, 1974, Volume: 24, Issue:6 Topics: Acetaminophen; Aminopyrine; Analgesics; Chromatography, Gas; Hypnotics and Sedatives; Methods; Microchemistry; Phenobarbital; Phenytoin; Primidone; Temperature	1974
An evaluation of a drug administration system in a psychiatric hospital. The British journal of psychiatry : the journal of mental science, 1974, Volume: 125, Issue:0 Topics: Acetaminophen; Antidepressive Agents; Benzodiazepinones; Hospitals, Psychiatric; Humans; Medication Errors; Medication Systems, Hospital; Phenobarbital; Phenothiazines; Phenytoin; Primidone; Salicylates; Scotland	1974
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Cysteamine; Cytochrome P-450 Enzyme System; Desipramine; Dimercaprol; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Humans; Indicators and Reagents; Liver; Male; Mass Spectrometry; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Sulfhydryl Compounds; Time Factors; Tritium	1974
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding. Biochemical pharmacology, 1974, Nov-01, Volume: 23, Issue:21 Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; Enzymes; Glucuronates; Glutathione; Half-Life; Intestinal Absorption; Kidney; Kinetics; Liver Diseases; Metabolism; Methylcholanthrene; Mice; Models, Theoretical; Necrosis; Phenobarbital; Proadifen; Rats; Regional Blood Flow; Sulfates; Toxicology	1974
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology, 1974, Volume: 12, Issue:3 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Glutathione; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes, Liver; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Stimulation, Chemical	1974
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. Pharmacology, 1974, Volume: 12, Issue:4-5 Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass Spectrometry; Methylcholanthrene; Mice; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Stimulation, Chemical; Tritium	1974
[Clinical pharmacology of common analgesics, narcotics and sedatives (tranquilizers)]. Der Internist, 1972, Volume: 13, Issue:5 Topics: Acetaminophen; Analgesics; Aspirin; Barbiturates; Chloral Hydrate; Diazepam; Drug Synergism; Humans; Hypnotics and Sedatives; Limbic System; Meprobamate; Phenacetin; Phenobarbital; Salicylates; Secobarbital; Tranquilizing Agents	1972
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scottish medical journal, 1973, Volume: 18, Issue:2 Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Drug Synergism; Ethanol; Female; Half-Life; Humans; Hydroxybutyrate Dehydrogenase; Imipramine; L-Lactate Dehydrogenase; Liver Diseases; Male; Middle Aged; Necrosis; Phenobarbital	1973
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Kidney; Lethal Dose 50; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Time Factors; Tritium	1973
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cobalt; In Vitro Techniques; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Mitochondria, Liver; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Time Factors; Tritium	1973
The effect of phenobarbitone pretreatment on paracetamol toxicity. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1973, Nov-20, Volume: 19, Issue:11 Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Interactions; Enzyme Induction; Female; Liver; Necrosis; Phenobarbital; Rats; Statistics as Topic	1973
Analysis of acetaminophen and barbiturate combinations by differentiating nonaqueous titration. Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:1 Topics: Acetaminophen; Bromides; Capsules; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Dimethylformamide; Indicators and Reagents; Methods; Phenobarbital; Potentiometry; Quaternary Ammonium Compounds; Sulfates; Tablets	1974
A sensitive, specific method for measuring N-acetyl-p-aminophenol (paracetamol) in blood. Clinica chimica acta; international journal of clinical chemistry, 1974, May-17, Volume: 52, Issue:3 Topics: Acetaminophen; Amobarbital; Chlordiazepoxide; Evaluation Studies as Topic; Humans; Indicators and Reagents; Methods; Microchemistry; Pentobarbital; Phenobarbital; Salicylates; Spectrophotometry, Ultraviolet; Theophylline	1974
[Increased rate of glucuronidation in the human and animal newborn by therapeutic doses of phenobarbital]. Zeitschrift fur Kinderheilkunde, 1972, Volume: 113, Issue:1 Topics: Acetaminophen; Administration, Oral; Animals; Animals, Newborn; Bilirubin; Biotransformation; Chromatography, Gas; Enzyme Induction; Evaluation Studies as Topic; Female; Glucuronates; Hexosyltransferases; Humans; Infant, Newborn; Metabolic Clearance Rate; Phenobarbital; Pregnancy; Rabbits; Time Factors	1972
Drug interference with measurement of adrenal hormones in urine: analgesics and tranquilizer-sedatives. Annals of internal medicine, 1971, Volume: 75, Issue:5 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acetaminophen; Adrenal Cortex Hormones; Adult; Analgesics; Aspirin; Catecholamines; Chlordiazepoxide; Colorimetry; Dextropropoxyphene; Diazepam; Diphenhydramine; Drug Interactions; Fluorometry; Humans; Hypnotics and Sedatives; Male; Pentazocine; Phenobarbital; Tranquilizing Agents	1971
The value of physiotherapy in obstetrics. The Medical journal of Australia, 1970, Jun-06, Volume: 1, Issue:23 Topics: Acetaminophen; Anesthesia, Obstetrical; Anesthetics, Local; Aspirin; Codeine; Conditioning, Psychological; Exercise Therapy; Female; Glutethimide; Humans; Infant, Newborn; Labor, Obstetric; Meperidine; Morphine; Natural Childbirth; Nitrous Oxide; Obstetric Labor Complications; Papaverine; Paraldehyde; Pentobarbital; Perineum; Phenobarbital; Physical Examination; Pregnancy; Promazine; Psychophysiology; Psychotherapy; Relaxation; Statistics as Topic	1970
Effect on newborn rats of perinatal exposure to phenobarbital. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Animals, Newborn; Antipyrine; Brain; Female; Hexobarbital; Microsomes, Liver; Nitrophenols; Phenobarbital; Pregnancy; Pyrazoles; Rats; Sleep; Spectrophotometry	1970
Seizures and fever. Postgraduate medicine, 1971, Volume: 50, Issue:1 Topics: Acetaminophen; Acidosis, Respiratory; Age Factors; Alkalosis, Respiratory; Aspirin; Brain Diseases; Child, Preschool; Electroencephalography; Fever; Gastrointestinal Diseases; Humans; Hyponatremia; Infant; Phenobarbital; Phenytoin; Prognosis; Respiratory Tract Infections; Seizures; Syncope	1971
Effect of bilirubin on drug conjugations in children. Pediatrics, 1971, Volume: 47, Issue:5 Topics: Acetaminophen; Adult; Bilirubin; Biological Transport, Active; Biotransformation; Child; Female; Glucuronates; Humans; Hyperbilirubinemia, Hereditary; Liver; Oxidative Phosphorylation; Phenobarbital; Salicylamides; Salicylates; Transferases	1971
Analgesic profile of tranquillizers in multiple screening tests in mice. Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 176, Issue:1 Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Chlorpromazine; Codeine; Diazepam; Diphenhydramine; Electric Stimulation; Haloperidol; Hot Temperature; Hydroxyzine; Imipramine; Isocarboxazid; Male; Meprobamate; Mice; Morphine; Perphenazine; Phenobarbital; Phenothiazines; Promazine; Promethazine; Reserpine; Tetrabenazine; Thiopental; Time Factors; Tranquilizing Agents	1968
Interactions between pharmaceutical compounds by thermal methods. Journal of pharmaceutical sciences, 1969, Volume: 58, Issue:3 Topics: Acetaminophen; Aspirin; Atropine; Bile Acids and Salts; Caffeine; Drug Compounding; Drug Incompatibility; Drug Stability; Methods; Phenacetin; Phenobarbital; Phenytoin; Quinine; Temperature; Theophylline; Thermodynamics; Time Factors; Vitamin K	1969
[Therapeutic value of Febrectol (22ò4C) in benign respiratory infections in infants and children]. Gazette medicale de France, 1965, Oct-10, Volume: 72, Issue:19 Topics: Acetaminophen; Child; Child, Preschool; Female; Humans; Infant; Male; Phenobarbital; Respiratory Tract Infections	1965
[Report of experimentation with febrectol]. Semaine therapeutique, 1965, Volume: 41, Issue:10 Topics: Acetaminophen; Adult; Aged; Female; Fever; Humans; Male; Middle Aged; Phenobarbital; Respiratory Tract Infections; Virus Diseases	1965
[Metabolic transformation of phenacetin and N-acetyl-p-aminophenol after pretreatment with phenobarbital]. Biochemical pharmacology, 1967, Volume: 16, Issue:8 Topics: Acetaminophen; Animals; Phenacetin; Phenobarbital; Rats	1967
Potentiation of carbon tetrachloride hepatotoxicity by beta-phenethyl alcohol. Acta medica Okayama, 1984, Volume: 38, Issue:5 Topics: Acetaminophen; Alanine Transaminase; Alcohols; Animals; Carbon Tetrachloride; Drug Synergism; Ethanol; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylethyl Alcohol; Rats; Rats, Inbred Strains	1984
Protection against paracetamol-induced glutathione depletion following a paracetamol-acetylsalicylic acid mixture or benorilate in phenobarbital-treated rats. Toxicology letters, 1981, Volume: 9, Issue:4 Topics: Acetaminophen; Animals; Aspirin; Glutathione; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Salicylates	1981
Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein. Archives of toxicology, 1980, Volume: 45, Issue:1 Topics: Acetaminophen; Animals; Catechin; Chemical and Drug Induced Liver Injury; Deanol; Dimethyl Sulfoxide; Ditiocarb; In Vitro Techniques; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Time Factors	1980
Role of microsomal drug detoxifying enzyme systems in paracetamol induced liver injury in rats. The Indian journal of medical research, 1983, Volume: 78 Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Glucose-6-Phosphatase; Liver Diseases; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains	1983
Apparent potentiation of hepatotoxicity from small doses of acetaminophen by phenobarbital. Annals of internal medicine, 1984, Volume: 101, Issue:3 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Humans; Middle Aged; Phenobarbital	1984
Effects of phenobarbital, GSH-depletors, CCl4 and ethanol on the biliary efflux of glutathione in rats. Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 266, Issue:2 Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Dichloroethylenes; Ethanol; Glutathione; Ketones; Male; Phenobarbital; Rats; Rats, Inbred Strains	1983
The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro. Chemico-biological interactions, 1984, Volume: 48, Issue:3 Topics: Acetaminophen; Amino Acids; Animals; Benzoquinones; Caseins; Cysteine; Glutathione; Imines; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; NADP; Phenobarbital; Proteins; Serum Albumin, Bovine	1984
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat. Archives of toxicology, 1984, Volume: 55, Issue:1 Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Maleates; Paraquat; Phenobarbital; Rats; Rats, Inbred Strains	1984
Metabolic activation of paracetamol by highly purified forms of cytochrome P-450. Research communications in chemical pathology and pharmacology, 1983, Volume: 40, Issue:1 Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Epoxide Hydrolases; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1983
The influence of nutrition and inducers on mechanisms of toxicity in humans and animals. Ciba Foundation symposium, 1980, Volume: 76 Topics: Acetaminophen; Animals; Anticonvulsants; Calcium; Carcinogens; Cytochrome P-450 Enzyme System; Epilepsy; Food Additives; Humans; Liver; Nutritional Physiological Phenomena; Phenobarbital; Rats; Toxicology; Vitamin E	1980
[Toxicology and therapy of paracetamol poisoning]. Der Internist, 1980, Volume: 21, Issue:12 Topics: Acetaminophen; Acetylcysteine; Cysteamine; Drug Interactions; Ethanol; Gastric Lavage; Glutathione; Half-Life; Methionine; Phenobarbital; Poisoning	1980
Experience with activated carbon-bead haemoperfusion columns in the treatment of severe drug intoxication. A preliminary report. Archives of toxicology, 1982, Volume: 49, Issue:3-4 Topics: Acetaminophen; Adolescent; Adult; Aged; Charcoal; Female; Glutethimide; Hemoperfusion; Humans; Phenobarbital; Poisoning; Theophylline	1982
Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. Toxicology, 1982, Volume: 25, Issue:2-3 Topics: Acetaminophen; Animals; Hypothermia; Male; Mice; Phenobarbital; Piperonyl Butoxide; Proadifen; Time Factors; Tissue Distribution	1982
Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system. Biochemical pharmacology, 1982, Dec-01, Volume: 31, Issue:23 Topics: Acetaminophen; Animals; Catechin; Cell Survival; Cells, Cultured; Flavonoids; Glutathione; Isocitrate Dehydrogenase; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1982
[A comparative pharmacokinetic study for tablet and suppository formulations of a combination product of caffeine, ethaverine, propyphenazone, paracetamol and phenobarbital (author's transl)]. Arzneimittel-Forschung, 1981, Volume: 31, Issue:1 Topics: Acetaminophen; Adult; Analgesics; Antipyrine; Caffeine; Drug Combinations; Humans; Kinetics; Male; Papaverine; Phenobarbital; Rectum; Suppositories; Tablets	1981
Sorption kinetics in haemoperfusion columns. Part 1: estimation of mass-transfer parameters. Medical & biological engineering & computing, 1981, Volume: 19, Issue:5 Topics: Acetaminophen; Adsorption; Creatinine; Hemoperfusion; Kinetics; Models, Chemical; Phenobarbital; Salicylates	1981
Effect of acetone on the activation of acetaminophen. Toxicology and applied pharmacology, 1980, Mar-30, Volume: 53, Issue:1 Topics: Acetaminophen; Acetone; Animals; Biotransformation; Drug Interactions; Glutathione; Kinetics; Liver; Male; Microsomes, Liver; NAD; Phenobarbital; Rats	1980
Drug interactions with acetaminophen: effects of phenobarbital, prednisone and 5-fluorouracil in normal and tumor-bearing rats. Biochemical pharmacology, 1980, Apr-15, Volume: 29, Issue:8 Topics: Acetaminophen; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Galactosamine; Inactivation, Metabolic; Liver Neoplasms, Experimental; Male; Neoplasms, Experimental; Phenobarbital; Prednisolone; Prednisone; Rats; Rats, Inbred ACI	1980
Genetic differences in cataract and other ocular abnormalities induced by paracetamol and naphthalene. Pharmacology, 1980, Volume: 20, Issue:5 Topics: Acetaminophen; Administration, Oral; Animals; Cataract; Cytochrome P-450 Enzyme System; Enzyme Induction; Eye; Eye Diseases; Female; Glutathione; Injections, Intraperitoneal; Lens, Crystalline; Liver; Male; Mice; Mice, Inbred Strains; Naphthalenes; Phenobarbital; Species Specificity	1980
Additive effects of inducers and fasting on acetaminophen hepatotoxicity. Biochemical pharmacology, 1980, Aug-15, Volume: 29, Issue:16 Topics: Acetaminophen; Animals; Enzyme Induction; Fasting; Glutathione; Liver; Male; Methylcholanthrene; Phenobarbital; Rats	1980
Impurities, adulterants and diluents of illicit heroin. Changes during a 12-year period. Forensic science international, 1994, Volume: 64, Issue:2-3 Topics: Acetaminophen; Caffeine; Carbohydrates; Denmark; Drug Contamination; Heroin; Hydrogen-Ion Concentration; Illicit Drugs; Lactose; Morphine; Noscapine; Papaverine; Phenobarbital; Procaine	1994
Effect of phenobarbital and p-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: use of a kinetic model to examine the rates of formation and egress. Journal of pharmacokinetics and biopharmaceutics, 1993, Volume: 21, Issue:2 Topics: Acetaminophen; Animals; Bile; Extracellular Space; Glucuronates; In Vitro Techniques; Liver; Male; Models, Biological; Phenobarbital; Rats; Rats, Sprague-Dawley; Regression Analysis; Sulfates	1993
Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:7 Topics: Acetaminophen; Acetone; Animals; Antineoplastic Agents; Benzoflavones; beta-Naphthoflavone; Cyclohexenes; Cytochrome P-450 Enzyme System; Glutathione; Limonene; Male; Mice; Microsomes, Liver; Oxygenases; Phenobarbital; Terpenes	1993
Acetaminophen hepatotoxicity: influence of phenobarbital and beta-naphthoflavone treatment in obese and lean Zucker rats. Toxicology and applied pharmacology, 1993, Volume: 123, Issue:2 Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Activation; Liver; Male; Mixed Function Oxygenases; Obesity; Phenobarbital; Rats; Rats, Zucker	1993
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3 Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzoquinones; beta-Naphthoflavone; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Activation; Female; Imines; Isoenzymes; Kinetics; Liver Diseases; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital	1993
Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3 Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Glutathione; Isoenzymes; Liver; Male; Obesity; Phenobarbital; Rats; Rats, Zucker; Sulfuric Acids	1993
Adenosine triphosphate (ATP) levels in paracetamol-induced cell injury in the rat in vivo and in vitro. Toxicology, 1995, Dec-15, Volume: 104, Issue:1-3 Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Drug Overdose; In Vitro Techniques; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Male; Phenobarbital; Potassium; Rats; Rats, Wistar	1995
National Association of Medical Examiners Pediatric Toxicology (PedTox) Registry Report 3. Case submission summary and data for acetaminophen, benzene, carboxyhemoglobin, dextromethorphan, ethanol, phenobarbital, and pseudoephedrine. The American journal of forensic medicine and pathology, 1995, Volume: 16, Issue:4 Topics: Acetaminophen; Benzene; Carboxyhemoglobin; Child, Preschool; Coroners and Medical Examiners; Dextromethorphan; Drug-Related Side Effects and Adverse Reactions; Ephedrine; Ethanol; Female; Humans; Infant; Infant, Newborn; Male; Phenobarbital; Registries; Societies, Medical	1995
Effects of phenobarbital on aniline metabolism in primary liver cell culture of rats with ethionine-induced liver disorder. Experimental animals, 1996, Volume: 45, Issue:2 Topics: Acetaminophen; Aminophenols; Aniline Compounds; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Culture Media; Ethionine; Female; Kinetics; Liver; Liver Diseases; Phenobarbital; Rats; Rats, Sprague-Dawley	1996
Status epilepticus following intravenous N-acetylcysteine therapy. Israel journal of medical sciences, 1996, Volume: 32, Issue:11 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anticonvulsants; Blindness; Child, Preschool; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Phenobarbital; Status Epilepticus	1996
A rapid in vitro assay for evaluation of metabolism-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1997, Volume: 37, Issue:2 Topics: Acetaminophen; Animals; Anticonvulsants; Biological Assay; Carbamazepine; Cell Count; Cell Survival; Female; Fluorescence; Humans; In Vitro Techniques; Lymphocytes; Microsomes, Liver; Phenobarbital; Phenytoin; Rabbits	1997
Comparison of paracetamol-induced hepatotoxicity in the rat in vivo with progression of cell injury in vitro in rat liver slices. Drug and chemical toxicology, 1998, Volume: 21, Issue:4 Topics: Acetaminophen; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Models, Biological; Necrosis; Phenobarbital; Rats; Rats, Wistar; Time Factors; Vitamin E	1998
Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes. European journal of pharmacology, 1999, Feb-26, Volume: 368, Issue:1 Topics: Acetaminophen; Acute-Phase Proteins; Albumins; Analgesics, Non-Narcotic; Animals; Carcinogens; Cell Survival; Cells, Cultured; Coculture Techniques; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Down-Regulation; Isoenzymes; Kupffer Cells; Lipopolysaccharides; Liver; Male; Methylcholanthrene; Nitric Oxide; Phenobarbital; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Xenobiotics	1999
The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10 Topics: Acetaminophen; Animals; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Hepatocytes; Humans; Nitrophenols; Pentachlorophenol; Phenobarbital; Protein Biosynthesis; Proteins; Swine; Thiazoles; Thiazolidinediones; Troglitazone	2000
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin. International journal of tissue reactions, 2001, Volume: 23, Issue:1 Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acids; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Metacarpophalangeal Joint; Middle Aged; Neuralgia; Pain; Phenobarbital; Reflex Sympathetic Dystrophy; Shoulder Pain; Treatment Outcome; Ulnar Nerve; Wrist Joint	2001
Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:9 Topics: Acetaminophen; Animals; Bile; Cell Line; In Vitro Techniques; Liver; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Phenobarbital; Rats; Rats, Wistar; Transfection; Transport Vesicles	2002
A novel model of acetaminophen-induced acute hepatic failure in rabbits. The Journal of surgical research, 2002, Volume: 106, Issue:2 Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Animal; Drug Synergism; Glutathione; Hepatic Encephalopathy; Injections, Intravenous; Injections, Subcutaneous; Liver; Liver Failure; Male; Methylcholanthrene; Phenobarbital; Rabbits	2002
Toxicology. Protecting liver from painkiller's lethal dose. Science (New York, N.Y.), 2002, Oct-11, Volume: 298, Issue:5592 Topics: Acetaminophen; Analgesics, Non-Narcotic; Androstanols; Animals; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Drug Overdose; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Liver Failure, Acute; Mice; Mice, Transgenic; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2002
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science (New York, N.Y.), 2002, Oct-11, Volume: 298, Issue:5592 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Mice; Mice, Knockout; Mice, Transgenic; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors	2002
HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets. Farmaco (Societa chimica italiana : 1989), 2002, Volume: 57, Issue:9 Topics: Acetaminophen; Analgesics; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Drug Combinations; Pharmaceutical Preparations; Phenobarbital; Reproducibility of Results; Tablets	2002
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:9 Topics: Acetaminophen; Allyl Compounds; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Branched DNA Signal Amplification Assay; Drug Resistance, Multiple; Kidney; Liver; Male; Mitochondrial Proteins; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Ribosomal Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Stilbenes; Sulfides; Thiones; Thiophenes; Time Factors	2003
Conjugation metabolism of acetaminophen and bilirubin in extrahepatic tissues of rats. Life sciences, 2004, Jan-23, Volume: 74, Issue:10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bilirubin; Biotransformation; Chromatography, High Pressure Liquid; Glucuronides; Histamine H2 Antagonists; Hypnotics and Sedatives; Liver Function Tests; Phenobarbital; Ranitidine; Rats; Rats, Sprague-Dawley; Sulfates	2004
[Migraine therapy with migraine kranit]. Die Medizinische Welt, 1951, Sep-15, Volume: 20, Issue:37 Topics: Acetaminophen; Antipyrine; Caffeine; Drug Combinations; Humans; Migraine Disorders; Muscle Relaxants, Central; Papaverine; Phenobarbital	1951
Effect of paracetamol on uric acid determination. Annals of clinical biochemistry, 1975, Volume: 12, Issue:4 Topics: Acetaminophen; Adult; Anticonvulsants; Autoanalysis; Bromides; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; False Positive Reactions; Female; Humans; Oxidation-Reduction; Phenobarbital; Phenytoin; Phosphotungstic Acid; Severity of Illness Index; Substance-Related Disorders; Time Factors; Urate Oxidase; Uric Acid	1975
Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 87, Issue:1 Topics: Acetaminophen; Cells, Cultured; Drug Interactions; Glucuronides; Glucuronosyltransferase; Glutathione; Hepatocytes; Humans; Liver; Phenobarbital; Phenytoin	2005
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy. Clinical chemistry, 2005, Volume: 51, Issue:10 Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertrophy; Liver Diseases; Male; Methylcellulose; Organ Size; Phenobarbital; Proteomics; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity	2005
Antioxidant and hepatoprotective effects of Eucalyptus maculata. Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:11 Topics: Acetaminophen; Animals; Antioxidants; Eucalyptus; Liver; Mice; Mice, Inbred Strains; Oxidative Stress; Paraquat; Phenobarbital; Phenols; Plant Extracts; Protective Agents; Rats; Rats, Inbred Strains; Sleep	2005
Method for screening and quantitative determination of serum levels of salicylic Acid, acetaminophen, theophylline, phenobarbital, bromvalerylurea, pentobarbital, and amobarbital using liquid chromatography/electrospray mass spectrometry. Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:1 Topics: Acetaminophen; Acidosis; Adult; Amobarbital; Analgesics, Non-Narcotic; Bromisovalum; Calibration; Chromatography, Liquid; Female; Humans; Hypnotics and Sedatives; Indicators and Reagents; Pentobarbital; Phenobarbital; Reproducibility of Results; Salicylic Acid; Spectrometry, Mass, Electrospray Ionization; Theophylline; Vasodilator Agents	2006
Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Biochemical and biophysical research communications, 2006, Aug-25, Volume: 347, Issue:2 Topics: Acetaminophen; Active Transport, Cell Nucleus; Adenoviridae; Animals; Blotting, Northern; Cell Nucleus; Cells, Cultured; Constitutive Androstane Receptor; Cytoplasm; Gene Expression; Genetic Vectors; Genotype; Green Fluorescent Proteins; Hepatocytes; Immunoblotting; Intracellular Signaling Peptides and Proteins; Liver; Mediator Complex Subunit 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Nuclear Receptor Coactivators; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Transcription Factors	2006
[Changes in emotional state and learning process disorders in rats with experimental hepatic encephalopathy]. Georgian medical news, 2006, Issue:135 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Emotions; Hepatic Encephalopathy; Hypnotics and Sedatives; Learning; Learning Disabilities; Male; Motor Activity; Phenobarbital; Rats	2006
Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liver. Gene expression, 2007, Volume: 13, Issue:4-5 Topics: Acetaminophen; Active Transport, Cell Nucleus; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Cells, Cultured; Constitutive Androstane Receptor; Gene Expression Regulation; Gene Targeting; Hepatocytes; Intracellular Signaling Peptides and Proteins; Liver; Male; Mice; Mice, Transgenic; Muscle Relaxants, Central; Nuclear Receptor Coactivators; Organ Size; Phenobarbital; PPAR alpha; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcription, Genetic; Zoxazolamine	2007
Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2 Topics: Acetaminophen; Animals; Clofibrate; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Dietary Fats; Dietary Sucrose; Female; Glucuronosyltransferase; Jejunum; Liver; Male; Microsomes, Liver; Organic Anion Transporters; Phenanthrolines; Phenobarbital; PPAR alpha; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors	2008
Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Body Weight; Choline Deficiency; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Gene Expression Regulation, Enzymologic; Glutathione; Glutathione Transferase; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar	2009
Scoring multiple toxicological endpoints using a toxicogenomic database. Toxicology letters, 2009, Jul-24, Volume: 188, Issue:2 Topics: 2-Acetylaminofluorene; Acetaminophen; Algorithms; Animals; Biomarkers; Clofibrate; Data Interpretation, Statistical; Databases, Genetic; Endpoint Determination; Gene Expression; Liver; Male; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Toxicity Tests; Toxicogenetics	2009
[Pain perception and pain therapy in premature infants]. Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2010, Volume: 29, Issue:5 Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Infant; Infant Care; Infant, Newborn; Infant, Premature; Morphine; Pain; Pain Management; Pain Measurement; Pain, Postoperative; Perception; Phenobarbital; Pirinitramide; Surveys and Questionnaires; Time Factors; World Health Organization	2010
Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Jun-14, Volume: 43, Issue:3 Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Area Under Curve; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Clarithromycin; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Male; Mass Spectrometry; Middle Aged; Phenobarbital; Propafenone; Sumatriptan	2011
Qualitest recalls tablets mislabeled as phenobarbital. Journal of the American Veterinary Medical Association, 2011, Apr-15, Volume: 238, Issue:8 Topics: Acetaminophen; Drug Combinations; Drug Labeling; Drug Recalls; Hydrocodone; Phenobarbital	2011
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glutathione; Imines; Liver; Liver Diseases; Magnetic Resonance Imaging; Male; Metabolomics; Oxidation-Reduction; Oxidative Stress; Phenobarbital; Rats; Rats, Inbred F344	2011
A high sensitive voltammetric sensor for qualitative and quantitative determination of phenobarbital as an antiepileptic drug in presence of acetaminophen. Colloids and surfaces. B, Biointerfaces, 2012, Jun-15, Volume: 95 Topics: Acetaminophen; Anticonvulsants; Electrochemical Techniques; Electrodes; Humans; Phenobarbital	2012
Developmental pharmacokinetics of propylene glycol in preterm and term neonates. British journal of clinical pharmacology, 2013, Volume: 75, Issue:1 Topics: Acetaminophen; Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Models, Biological; Phenobarbital; Pregnancy; Propylene Glycol	2013
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen. Archives of toxicology, 2013, Volume: 87, Issue:8 Topics: Acetaminophen; Animals; beta Catenin; Carcinogens; Cell Proliferation; Cytochrome P-450 CYP2E1; Diethylnitrosamine; Dose-Response Relationship, Drug; Hepatocytes; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mutation; Phenobarbital	2013
Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Therapeutic drug monitoring, 2014, Volume: 36, Issue:3 Topics: Acetaminophen; Computer Simulation; Excipients; Female; Gestational Age; Hepatobiliary Elimination; Humans; Infant, Newborn; Infant, Premature; Male; Models, Biological; Phenobarbital; Propylene Glycol; Renal Elimination	2014
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats. The Journal of toxicological sciences, 2014, Volume: 39, Issue:5 Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Glutathione Transferase; Liver Neoplasms; Male; Methapyrilene; Mutagenicity Tests; Oxidative Stress; Phenobarbital; Rats, Sprague-Dawley; Thioacetamide	2014
Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:3 Topics: Acetaminophen; Animals; Brain; Glucuronosyltransferase; Histones; Male; Oxidative Stress; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcriptional Activation	2016
Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 36 Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Cell Proliferation; Cell Survival; Cells, Cultured; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; DNA; Epidermal Growth Factor; Hepatocytes; Humans; Male; Membrane Proteins; Mice; Microscopy, Fluorescence; Oximes; Phenobarbital; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Species Specificity; Steroid Hydroxylases; Thiazoles	2016