acetaminophen has been researched along with phenacetin in 399 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 291 (72.93) | 18.7374 |
| 1990's | 47 (11.78) | 18.2507 |
| 2000's | 28 (7.02) | 29.6817 |
| 2010's | 29 (7.27) | 24.3611 |
| 2020's | 4 (1.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prescott, LF | 6 |
| Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Brozic, P; Gobec, S; Rizner, TL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Anderluh, M; Brunskole, M; Gobec, S; Lanisnik Rizner, T; Stefane, B; Stojan, J; Zorko, K | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Balko, KM; Colby, DA; Mo, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Bowalgaha, K; Elliot, DJ; Knights, KM; Miners, JO; Rowland, A; Tassaneeyakul, W; Wattanachai, N | 1 |
| Deshmukh, RS; Ericksen, SS; Huang, Q; Szklarz, GD; Tu, Y | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Baty, JD; Robinson, PR; Wharton, J | 1 |
| Obiorah, BA; Shotton, E | 3 |
| Miller, RR | 1 |
| Hinson, JA; Mitchell, JR; Nelson, SD | 1 |
| Carreon, OH; Ridgway, K | 1 |
| Jager, LP; Seegers, AJ; Van Noordwijk, J | 2 |
| Efentakis, E; Fell, JT | 1 |
| Baumeler, HR; Dubach, UC; Ehrensperger, T; Levy, PS; Müller, A; Peier, A; Rosner, B | 1 |
| Idle, JR; Lancaster, R; Mahgoub, A; Sloan, TP; Smith, RL | 1 |
| Mitchell, JR; Potter, WZ | 1 |
| Duhamel, G; Gorin, NC; Najman, A | 1 |
| Austin, TW; Truant, G | 1 |
| Brunner, FP; Dubach, UC; Richtmann, L; Thiel, G | 1 |
| Biesterfeld, RC; Taintor, JF; Valle, GF | 1 |
| Bowman, BJ; Glenn, EM; Rohloff, NA | 1 |
| Kapetanović, IM; Mieyal, JJ; Strong, JM | 1 |
| Kapetanović, IM; Mieyal, JJ | 1 |
| Bridges, JW; Fry, JR; Gwynn, J | 1 |
| Dubach, UC | 7 |
| Gillette, JR; Hinson, JA; Nelson, SD | 1 |
| Gillette, JR; Pang, KS | 2 |
| Gillette, JR; Hinson, JA; Pohl, LR | 2 |
| Inaba, T; Mahon, WA; Stone, RM | 1 |
| Gillette, JR; Hinson, JA; Pang, KS; Taburet, AM | 1 |
| Domagalina, E; Zareba, S | 1 |
| Baum, RG; Cantwell, FF | 1 |
| Heilmann, E; Werner, W | 1 |
| Chang, RL; Conney, AH; Klutch, A; Levin, W; Vane, F | 1 |
| Gillette, JR; Hinson, JA; Mulder, GJ | 1 |
| Molland, EA | 1 |
| Goldberg, M; Murray, TG | 1 |
| Forte, AJ; McMurtry, RJ; Nelson, SD | 1 |
| McLean, S | 1 |
| Davis, BB; Herman, CA; Joshi, S; Mattammal, MB; Zenser, TV | 1 |
| Anderson, KE; Conney, AH; Garland, WA; Kappas, A; Min, BH; Pantuck, CB; Pantuck, EJ; Wattenberg, LW | 1 |
| Dybing, E; McMurtry, RJ; Mitchell, JR; Nelson, SD; Thorgeirsson, SS | 1 |
| Donatsch, P; Hodel, C; Pataki, A; Rentsch, G | 1 |
| Baty, JD; Robinson, PR | 2 |
| Conney, AH; Garland, WA; Hsiao, KC; Pantuck, EJ | 1 |
| Gotelli, GR; Kabra, PM; Marton, LJ | 1 |
| Cox, GB; Loscombe, CR; Sugden, K | 1 |
| Evans, MA; Harbison, RD | 1 |
| Griffiths, LA; Smith, GE | 1 |
| Ebel, S; Herold, G | 1 |
| Alvares, AP; Anderson, KE; Conney, AH; Garland, WA; Hsiao, KC; Kappas, A; Pantuck, EJ | 1 |
| Arnold, L; Collins, C; Starmer, GA | 2 |
| Margetts, G | 1 |
| Hart, A; Orr, DL | 1 |
| Hadler, NM | 1 |
| Nanra, RS | 1 |
| Gallery, E; Mahony, JF; McCarthy, SW; Roberts, BA; Stewart, JH; Storey, BG | 1 |
| Goldberg, M; Murray, T | 1 |
| Shively, CA; Vesell, ES | 1 |
| Atkins, CE; Johnson, RK | 1 |
| Parkhouse, J | 1 |
| Blandy, JP; Lewis, CT; Marshall, VR; Molland, EA; Tresidder, GC | 1 |
| Ellcock, CT; Fogg, AG | 1 |
| Axelsen, RA | 2 |
| Dubach, UC; Raaflaub, J | 2 |
| Selph, JL; Truax, JF; Vinegar, R | 1 |
| Dubach, UC; Rosner, B; Stürmer, T | 1 |
| Boobis, AR; Murray, S | 2 |
| Hornová, J; Rettinger, H | 1 |
| Starek, A | 1 |
| McLean, S; Veronese, ME | 1 |
| Eyanagi, R; Hisanari, Y; Shigematsu, H | 1 |
| Stolley, PD | 1 |
| Balcke, P; Derfler, K; Hauser, AC | 1 |
| Hurwitz, A; Parkinson, A | 1 |
| Acosta, D; Davis, PJ; Reddy, CS | 1 |
| Aboul Khier, A; el Sadek, M; el Shanawany, A; Rücker, G | 1 |
| Rachtan, R; Starek, A | 1 |
| Jensen, OM; Nørgaard, N | 1 |
| de Vries, JX; Küster, G; Mohr, T; Rieser, PF; Ritz, E; Waldherr, R; Walter-Sack, J | 1 |
| Chow, A; Goresky, CA; Pang, KS; Xu, N | 1 |
| Nakamura, J; Podder, SK; Sasaki, H; Shibasaki, J | 2 |
| Blythe, WB; Buckalew, VM; Burgess, WP; Dennis, VW; Sandler, DP; Smith, JC; Weinberg, CR | 1 |
| Keller, F; Kunzendorf, U; Offermann, G; Schwarz, A | 1 |
| Faber, U; Glaeske, G; Keller, F; Offermann, G; Schwarz, A | 1 |
| Park, BK | 1 |
| Bock, KD; Graben, N; Maruhn, D; Metz, U | 1 |
| Bamford, CR; Gillman, MA; Sandyk, R | 1 |
| Johansson, SL; Radio, SJ; Saidi, J; Sakata, T | 1 |
| Henderson, BE; Landolph, JR; Lehman, NL; Patierno, SR | 1 |
| Fischer, V; Harman, LS; Mason, RP; West, PR | 1 |
| Accaputo, J; Cherry, WF; Fayz, S; Goresky, CA; Lee, WF; Pang, KS; Schwab, AJ; Yuen, V | 1 |
| de Vries, J; Redegeld, FA; van Bree, L | 1 |
| Accaputo, J; Cherry, WF; Goresky, CA; Pang, KS; Schwab, AJ | 1 |
| Federowicz, DA; Kerns, W; Mico, BA; Ripple, MG | 1 |
| McCredie, M; Stewart, JH | 1 |
| Kramer, M | 1 |
| Oldham, JW; Paulson, JD; Preston, RF | 1 |
| Clissold, SP | 1 |
| Nakamura, J; Nakamura, T; Podder, SK; Sasaki, H; Shibasaki, J | 1 |
| Holme, JA; Søderlund, E | 1 |
| Ahmad, KS; Fatimah, Y; Kamal, A; Lim, KJ; Muhaya, HM; Musa, A; Rajagopalan, K; Segasothy, M | 1 |
| Bethke, BA; Schubert, GE | 2 |
| Roberts, MS; Rowland, M | 1 |
| Blot, WJ; Fraumeni, JF; McLaughlin, JK; Mehl, ES | 1 |
| Peterson, RG | 1 |
| Bach, PH; Bridges, JW | 1 |
| Matanoski, GM; Piper, JM; Tonascia, J | 1 |
| Nelson, SD | 1 |
| Joubert, PH; Modipane, A; Skene, DJ | 1 |
| Fischbach, T; Lenk, W | 1 |
| Brown, SS; Prescott, LF | 1 |
| Ahmann, DL; Moertel, CG; Schwartau, N; Taylor, WF | 1 |
| Jatlow, P | 1 |
| Coldwell, BB; Grice, HC; Zawidzka, ZZ | 1 |
| Asscher, AW; Elwood, PC; Waters, WE | 1 |
| Kampffmeyer, HG | 4 |
| O'Brien, JR | 1 |
| Bengtsson, V | 1 |
| Kasanen, A; Lehtonen, A; Näntö, V | 1 |
| Ganshorn, A; Kurz, H | 1 |
| de Weck, AL; Dubach, UC; Rüegger, R; Spengler, H | 1 |
| Schütt, A; Siegers, CP; Strubelt, O | 1 |
| Schneiderhan, W; Weger, N | 1 |
| Appel, GB; Franki, N; Gouaux, J; Hays, RM; Lozada, ES | 1 |
| Beyrich, T; Schleuder, M | 1 |
| Savidge, RA; Wragg, JS | 1 |
| Büch, H; Hey, D; Rummel, W; Staudinger, H; Ullrich, V | 1 |
| Schnitger, F; Uehleke, H | 1 |
| Fontvieille, J; Mounier-Kuhn, P | 1 |
| Dearden, JC; Tomlinson, E | 1 |
| Coldwell, BB; Thomas, BH | 1 |
| Rosenbaum, D | 1 |
| Coper, H | 1 |
| Cliff, JM | 1 |
| Messerich, J | 1 |
| Mills, JA | 1 |
| Bishop, J; Meltzer, AS; Znamirowska, MI | 1 |
| Barraclough, MA; Nilam, F | 1 |
| Kisara, K; Nagaoka, H; Niwa, H; Ozaki, S | 1 |
| Jurand, J; Knox, JH | 1 |
| Locket, S | 2 |
| Jürgensen Eide, G | 1 |
| Naess, K | 1 |
| Master, DR | 1 |
| Conney, AH; Hsiao, KC; Kuntzman, R; Maggio, A; Nakamura, K; Pantuck, EJ | 1 |
| Balmus, KJ; Meyer, DK; Meyler, L | 1 |
| de Weck, AL; Frey, JR; Geczy, A; Geleick, H | 1 |
| Burns, DT; Davis, DR; Fogg, AG; Wragg, JS | 1 |
| Vivaldi, E | 1 |
| Hunt, JN; Lallemand, RC | 1 |
| Anderson, G; Davis, CD; Ogden, JA; Wade, ME | 1 |
| Thorpe, P | 2 |
| Buchanan, WW; Dick, WC | 1 |
| Wigley, RD | 1 |
| Vandam, LD | 1 |
| Baechtold-Fowler, N; Bonjour, JP; Chométy-Diézi, F; Filloux, B; Guidoux, R; Guignard, JP; Hedinger, C; Peters, G; Peters-Haefeli, L; Roch-Ramel, F; Schelling, JL; Weber, E | 1 |
| Done, AK | 1 |
| Gabe, A; Gault, MH; Shahidi, NT | 1 |
| Murfin, JW | 1 |
| Murfin, JW; Wragg, JS | 1 |
| Conney, AH; Kuntzman, R; Pantuck, EJ | 1 |
| Kosunen, TU; Ruutu, T | 1 |
| Barraclough, MA | 1 |
| Trautmann, A | 1 |
| Boyd, EM | 2 |
| Ahmed, I; Olowe, O | 1 |
| Bagnasco, G; Cometti, A; Maggi, N | 1 |
| Burtis, CA; Stevenson, RL | 1 |
| Bakke, OM | 1 |
| De Szöcs, J; Grant, DJ | 1 |
| Kobayashi, S; Takagi, H | 1 |
| Nimmo, J; Prescott, LF | 1 |
| Davis, M; Lasagna, L; Pearson, JW | 1 |
| Eade, NR; Lasagna, L | 1 |
| van der Meer, J | 1 |
| Haudenschild, C | 1 |
| Goenechea, S | 2 |
| Kincaid-Smith, P | 1 |
| Armstrong, NA; Griffiths, RV | 2 |
| Kerr, D | 1 |
| de Wardener, HE; Koutsaimanis, KG | 1 |
| Abel, JA; Miley, RA | 1 |
| Emblem, L | 1 |
| Imashuku, S; LaBrosse, EH | 1 |
| Chafetz, L; Daly, RE; Lomner, JJ; Schriftman, H | 1 |
| Levy, G | 1 |
| Büch, H; Pfleger, K; Rüdiger, W | 1 |
| Goto, T; Nadai, T; Nakajima, Y; Tatematsu, A; Tsuyama, H | 1 |
| Bordun, M; Klutch, A | 1 |
| Bender, AD; Loev, B; Macko, E; Mirsky, JH; Tedeschi, RE; Walz, DT | 1 |
| Guillory, JK; Hwang, SC; Lach, JL | 1 |
| Dikstein, S; Grotto, M; Sulman, FG | 1 |
| Kadatz, R; Ueberberg, H | 1 |
| Bower, BF; Forsham, PH; Nusynowitz, ML; Wegienka, LC | 1 |
| Bereczky, GM; Boyd, EM | 1 |
| Burns, JJ; Conney, AH; Welch, RM | 1 |
| Friederiszick, FK; Toussaint, W | 1 |
| Büch, H; Häuser, H; Pfleger, K; Rüdiger, W | 1 |
| Krikler, DM | 1 |
| B4uch, H; Gerhards, W; Pfleger, K; Rüdiger, W; Rummel, W | 1 |
| de Vries, J | 1 |
| Johansson, S | 1 |
| Cinotti, GA | 1 |
| Hinson, JA | 1 |
| Hanks, GW | 1 |
| Haas, H | 1 |
| Luczynska, C; Wilson, K | 1 |
| D'Arcy, PF | 1 |
| Baumann, J; von Bruchhausen, F; Wurm, G | 2 |
| Ali, B; Bhargava, KP; Jain, MK; Kaul, R; Kaur, S; Misra, PK | 1 |
| Beaver, WT | 1 |
| MacSearraigh, ET; Seedat, YK | 1 |
| Cooper, M; Devonshire, HW; Idle, JR; Kong, I; Sloan, TP; Smith, RL | 1 |
| Obel, AO | 1 |
| Dycka, J; Hoffmeister, F; Rämsch, K | 1 |
| Forth, W | 1 |
| Baumann, J; von Bruchlausen, F | 1 |
| Andersson, B; Moldéus, P; Nordenskjöld, M; Rahimtula, A | 1 |
| Dubach, UC; Pfister, E; Rosner, B | 1 |
| Klippert, PJ; Littel, RJ; Noordhoek, J | 1 |
| Pang, KS | 1 |
| Bowser, MW; Calderazzo, JP; Foor, VM; Forbes, JA | 1 |
| Gillette, JR; Hinson, JA; Jollow, DJ; Mitchell, JR; Mulder, GJ; Nelson, SD; Pohl, LR | 1 |
| Casner, N; Compitello, R; Levine, S; Plakogiannis, FM; Saad, AM | 1 |
| Dybing, E; Thorgeirsson, SS; von Bahr, C; Wirth, PJ | 1 |
| Duggin, GG | 1 |
| Fishbein, L | 1 |
| Goldberg, M | 1 |
| Even-Adin, D; Vanherweghem, JL | 1 |
| Chan, KK; Horning, MG; Pang, KS; Waller, L | 1 |
| Balls, M; Clothier, RH; Horner, SA; Hosty, GS; Robertson, NJ | 1 |
| Goenechea, S; Kobbe, K | 1 |
| DeAngelis, RL; Findlay, JM; Findlay, JW; Kearney, MF; Welch, RM | 1 |
| Hikichi, N; Kyo, YN; Muranaka, Y; Niwa, H | 1 |
| Amidon, GE; Hiestand, EN; Smith, DP | 1 |
| Bass, L | 3 |
| Johansson, SL | 1 |
| Keseberg, A | 1 |
| Heymann, E; Mentlein, R; Rix, H | 1 |
| Calder, IC; Hart, SJ; Smail, MC; Tange, JD | 1 |
| Das Gupta, V | 1 |
| Zollinger, HU | 1 |
| Offerhaus, L | 1 |
| Boobis, AR; Brodie, MJ; Dollery, CT; Ellis, W; Harrison, R; Murray, S; Toverud, EL; Webster, S | 1 |
| Daniel, V; Howard, M; Nanra, RS | 1 |
| Fischer, W | 1 |
| Pang, KS; Terrell, JA | 1 |
| Chow, WH; Fraumeni, JF; Linet, MS; Lynch, C; McLaughlin, JK; Schoenberg, JB; Wacholder, S; Yu, MC | 1 |
| Doehmer, J; Jensen, KG; Loft, S; Poulsen, HE | 1 |
| Hagiwara, A; Hasegawa, R; Sano, M; Shibata, MA; Shirai, T | 1 |
| Lindblad, P; Mandel, JS; McCredie, M; McLaughlin, JK; Mellemgaard, A; Niwa, S; Pommer, W; Schlehofer, B; Stewart, JH | 1 |
| Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO | 1 |
| Lings, S; Nielsen, JB | 1 |
| Chow, WH; Linet, MS; Mandel, JS; McLaughlin, JK; Niwa, S | 1 |
| Barker, F; Cuerrier, G; Dlugosz, JA; Geng, W; Goresky, CA; Pang, KS; Schwab, AJ; Sherman, IA | 1 |
| Bartoli, A; Cipolla, G; Crema, F; Gatti, G; Perucca, E; Xiaodong, S | 1 |
| Donné-Op den Kelder, GM; Koymans, L; te Koppele, JM; Vermeulen, NP | 1 |
| Day, NE; McCredie, M; Stewart, JH | 1 |
| Vanchieri, C | 1 |
| Breckenridge, AM; Edwards, G; Glazier, AP; Kokwaro, GO; Ward, SA | 1 |
| Buckalew, VM | 1 |
| Behrend, M; Brunkhorst, R; Frei, U; Kliem, V; Koch, KM; Kolditz, M; Krautzig, S; Pichlmayr, R; Thon, W | 1 |
| Bartoli, A; Cipolla, G; Gatti, G; Marchiselli, R; Perucca, E; Xiaodong, S | 1 |
| Schwarz, A | 1 |
| Hörl, WH | 1 |
| Fautrel, A; Guillouzo, A; Guyomard, C; Joly, B | 1 |
| Caddick, S; Farrant, RD; Lindon, JC; Nicholls, AW; Nicholson, JK; Wilson, ID | 1 |
| Lunte, CE; Southard, MZ; Ståhle, L; Stenken, JA | 1 |
| Murthy, KC; Nagaraja, P; Rangappa, KS | 1 |
| Aicher, B; Baumeister, M | 1 |
| Barrett, BJ; Gault, MH | 1 |
| Preuschof, L; Schwarz, A; Zellner, D | 1 |
| Coakley, CJ; Gonzalez, FJ; Kimura, S; Morishima, H; Peters, JM; Ward, JM | 1 |
| Castelao, JE; Gago-Dominguez, M; Ross, RK; Yu, MC; Yuan, JM | 1 |
| Fox, JM | 1 |
| Chong Shu, C; D'urso, S; Fattore, C; Gatti, G; Perucca, E; Xiao Dong, S; Zhi Ping, Z; Zhong Xiao, W | 1 |
| Krause, S; Schöler, HF | 1 |
| Farrant, RD; Lindon, JC; Nicholls, AW; Nicholson, JK; Shockcor, JP; Wilson, ID | 1 |
| Abbott, FV; Hellemans, KG | 1 |
| Curhan, GC; Delzell, E; Deschepper, PJ; Feinstein, AR; Fox, JM; Graf, H; Heinemann, LA; Luft, FC; Michielsen, P; Mihatsch, MJ; Suissa, S; Van Der Woude, F; Willich, S | 1 |
| Czégány, Z; Harsányi, J; Homoki, M; Kassai, M; Kiss, E; Kiss, I; Ladányi, E; Lócsey, L; Major, L; Mátyus, J; Misz, M; Nagy, J; Nagy, L; Pintér, I; Polner, K; Pótó, L; Rédl, J; Solt, I; Tichy, B; Török, M; Varga, G; Wagner, G; Wittmann, I; Wórum, I; Zsoldos, B | 1 |
| Boobis, AR; Edwards, RJ; Murray, BP; Murray, S; Odupitan, AO | 1 |
| Angus, PW; Blake, CL; Ching, MS; Ghabrial, H; Malek, NA | 1 |
| BOREUS, LO; SANDBERG, F | 1 |
| DE QUAY, MB; DELMONTE, J; FROMMEL, E; GOLD, P; MELKONIAN, D; RADOUCO, C; VALETTE, F | 1 |
| MIESCHER, P; PLETSCHER, A; STUDER, A | 1 |
| BAADER, H; GIRGIS, S; KIESE, M; MENZEL, H; SKROBOT, L | 1 |
| COLLIER, HO; SHORLEY, PG | 1 |
| EISALO, A; TALANTI, S | 1 |
| ANGERVALL, L; LEHMANN, L; LINCOLN, K | 3 |
| VEST, M | 1 |
| HART, FD | 1 |
| WHITEHOUSE, MW | 1 |
| LOZINSKI, E | 1 |
| BAKER, JA; HAYDEN, J; MARSHALL, PG; PALMER, CH; WHITTET, TD | 1 |
| MANOLOV, P | 1 |
| ANGERVALL, L; BENGTSSON, U; LEHMANN, L | 1 |
| EDER, H | 1 |
| POGGENDORF, A; SEIDLEIN, HJ | 1 |
| CLAUSEN, E; LARSEN, OA | 1 |
| BROCKELT, G | 1 |
| KIESE, M; MENZEL, H | 1 |
| Goodin, MG; Rosengren, RJ; Walker, RJ | 1 |
| Hanna, I; Homann, MJ; Vail, RB; Zaks, A | 1 |
| Castañeda-Hernández, G; Cruz-Antonio, L; Flores-Murrieta, FJ; García-Löpez, P; Guízar-Sahagún, G | 1 |
| Bauer-Brandl, A; Perlovich, GL; Volkova, TV | 1 |
| Fodor, K; Léhman, A; Perjési, P | 1 |
| Michielsen, P | 1 |
| He, P; Li, XD; Liu, HL; Qu, ZQ; Wu, MC; Zhang, X | 1 |
| Fu, J; Mu, X; Zhang, L; Zhou, Z | 1 |
| Singh, AK; Trikudanathan, S; Vadivel, N | 1 |
| Irifune, M; Ishida, T; Nakamura, N; Nishikawa, T; Sato, T; Tanaka, K | 1 |
| Baber, SR; Hyman, AL; Kadowitz, PJ; Nazim, MM; Nossaman, BD; Waldron, PR | 1 |
| Chan, EC; New, LS; Tan, SC | 1 |
| Ding, N; He, P; Huang, W; Li, XD; Qu, ZQ; Wu, MC; Zhang, SL | 1 |
| Espina, R; Mutlib, A; Scatina, J; Talaat, R; Tong, Z; Vashishtha, S; Wang, J; Yu, L | 1 |
| Bailey, N; Graber, D; Kudugunti, SK; Moridani, MY; Srivenugopal, K; Vad, NM | 1 |
| Huang, Q; Szklarz, GD | 1 |
| Fukami, T; Kobayashi, Y; Nakagawa, N; Nakajima, M; Takahashi, S; Watanabe, A; Yokoi, T | 1 |
| Bhyrapuneni, G; Kandikere, V; Manoharan, A; Nirogi, R; Palacharla, Rc; Ponnamaneni, RK | 1 |
| Bischoff, R; Bruins, AP; Nouri-Nigjeh, E; Permentier, HP | 1 |
| Lentz, KA; Morgan, DG; Orcutt, TL; Sinz, MW; Whiterock, VJ | 1 |
| Jia, Y; Tian, Y; Wen, A; Xiao, A; Yang, M; Yang, P; Zhang, Y | 1 |
| Modelli, A; Pshenichnyuk, SA | 1 |
| Mimura, H; Nasu, M; Nemoto, T; Sako, K | 1 |
| Boujtita, M; Bussy, U; Giraudeau, P; Tea, I | 1 |
| Ding, Y; Gu, S; Jiang, F; Jiang, L; Zhang, Z | 1 |
| Anand Kumar, P; Prasad, VG; Rao, GS; Ravi Kumar, P; Vivek, Ch | 1 |
| Anton, PM; Bricks, T; Fleury, MJ; Leclerc, E; Legendre, A; Merlier, F; Paullier, P; Zeller, P | 1 |
| Kolavennu, A; Liu, S; Mobley, DL; Paluch, AS; Parameswaran, S | 1 |
| Duan, JA; Jing, XY; Peng, YR; Wang, XM | 1 |
| Mandal, A; Raju, S; Viswanathan, C | 1 |
| Lu, S; Ma, W; Ma, Y; Ren, R | 1 |
| Jiang, B; Jin, X; Meng, L; Zhang, F; Zhang, G | 1 |
| Dai, Y; Liu, B; Qiao, L; Yang, Y | 1 |
| Kuang, H; Liu, L; Wang, Z; Xu, C; Xu, X; Yao, J | 1 |
| Mizogami, M; Tsuchiya, H | 1 |
| Dong, YY; Huang, CK; Lang, LP; Li, QQ; Qian, JC; Sun, W; Wang, Z; Zhang, XD | 1 |
32 review(s) available for acetaminophen and phenacetin
| Article | Year |
|---|---|
Kinetics and metabolism of paracetamol and phenacetin.
Topics: Acetaminophen; Administration, Oral; Adult; Animals; Biotransformation; Humans; Intestinal Absorption; Kinetics; Metabolic Clearance Rate; Phenacetin; Tissue Distribution | 1980 |
Propoxyphene: a review.
Topics: Acetaminophen; Analgesics; Aspirin; Caffeine; Chemical Phenomena; Chemistry; Dextropropoxyphene; Drug Combinations; Drug Incompatibility; Heroin Dependence; Humans; Kinetics; Phenacetin; Substance-Related Disorders | 1977 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Drug Hypersensitivity; Ethers; Furosemide; Glutathione; Halothane; Humans; Inactivation, Metabolic; Isoniazid; Liver; Liver Neoplasms; Necrosis; Pharmaceutical Preparations; Phenacetin; Protein Binding; Thiophenes | 1975 |
[Tumors of the efferent parts of the urinary tract and abuse of analgesics].
Topics: Acetaminophen; Adult; Analgesics; Carcinoma, Squamous Cell; Choriocarcinoma; Female; Humans; Kidney Diseases; Kidney Neoplasms; Kidney Pelvis; Middle Aged; Occupational Diseases; Occupational Medicine; Phenacetin; Pregnancy; Sarcoma; Substance-Related Disorders; Uremia; Urogenital Neoplasms | 1978 |
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Necrosis; Phenacetin; Sulfhydryl Compounds | 1979 |
Phenacetin: an update.
Topics: Acetaminophen; Drug Combinations; Humans; Phenacetin | 1979 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hydrazines; Isoniazid; Liver; Methyldopa; Necrosis; Pharmaceutical Preparations; Phenacetin; Thiophenes | 1976 |
Analgesic abuse and renal disease.
Topics: Acetaminophen; Adult; Aged; Animals; Aspirin; Creatinine; Drug Combinations; Humans; Inactivation, Metabolic; Kidney Papillary Necrosis; Metabolic Clearance Rate; Middle Aged; Nephritis, Interstitial; Phenacetin; Rats; Substance-Related Disorders; United States | 1975 |
Clinical toxicities of cats.
Topics: Acetaminophen; Animals; Arsenic Poisoning; Aspirin; Benzoates; Bismuth; Cat Diseases; Cats; Chloramphenicol; Dichlorvos; Diuresis; Ethylene Glycols; Fuel Oils; Gastric Lavage; Griseofulvin; Hexachlorophene; Insecticides; Lead Poisoning; Mercury Poisoning; Methylene Blue; Morphine; Pentobarbital; Phenacetin; Phenols; Plant Poisoning; Rodenticides; Strychnine; Vitamin A | 1975 |
Simple analgesics.
Topics: Acetaminophen; Analgesics; Aspirin; Azepines; Carbamazepine; Codeine; Dextropropoxyphene; Drug Combinations; Flufenamic Acid; Humans; Mefenamic Acid; Pain; Phenacetin | 1975 |
Omeprazole and the induction of human cytochrome P-450: a response to concerns about potential adverse effects.
Topics: Acetaminophen; Carcinogens; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Omeprazole; Phenacetin | 1991 |
[Phenacetin, paracetamol and bladder cancer].
Topics: Acetaminophen; Humans; Phenacetin; Urinary Bladder Neoplasms | 1990 |
Paracetamol and phenacetin.
Topics: Acetaminophen; Drug Interactions; Humans; Phenacetin | 1986 |
Consequences associated with nonnarcotic analgesics in the fetus and newborn.
Topics: Acetaminophen; Adolescent; Adult; Animals; Aspirin; Blood Pressure; Cardiac Output; Child; Child, Preschool; Female; Fetus; Glucuronates; Humans; Infant; Infant, Newborn; Liver; Phenacetin; Platelet Aggregation; Pregnancy; Prostaglandins; Salicylamides; Sulfates | 1985 |
Chemically induced renal papillary necrosis and upper urothelial carcinoma. Part 1.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbohydrate Metabolism; Female; Glycosaminoglycans; Hemodynamics; Humans; Kidney Medulla; Kidney Papillary Necrosis; Lipid Metabolism; Male; Middle Aged; Nephrons; Phenacetin; Renal Circulation; Urinary Bladder Neoplasms | 1985 |
Non-narcotic analgesics--their use and abuse.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Aspirin; Dextropropoxyphene; Drug Synergism; Flufenamic Acid; Humans; Indomethacin; Mefenamic Acid; Methotrimeprazine; Orphenadrine; Oxyphenbutazone; Pentazocine; Phenacetin; Phenylbutazone; Propionates; Tablets | 1972 |
Unravelling analgesic nephropathy.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Carcinoma, Transitional Cell; Female; Humans; Kidney Neoplasms; Kidney Papillary Necrosis; Male; Microsomes, Liver; Phenacetin; Rats; Salicylates; Spermatogenesis; Substance-Related Disorders | 1972 |
Nonsteroidal anti-inflammatory drugs (first of two parts).
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Drug Hypersensitivity; Gastric Mucosa; Gout; Humans; Phenacetin; Phenylbutazone; Rheumatic Diseases; Salicylates; Stomach Diseases | 1974 |
Haemodialysis in the treatment of acute poisoning.
Topics: Acetaminophen; Adult; Alcohols; Aniline Compounds; Arsenic Poisoning; Barbiturates; Carbon Tetrachloride Poisoning; Chelating Agents; Child; Chloral Hydrate; Fluoride Poisoning; Glutethimide; Glycols; Humans; Infant; Iron; Lead Poisoning; Male; Mercury Poisoning; Methaqualone; Phenacetin; Poisoning; Renal Dialysis; Salicylates | 1970 |
Advances in the treatment of rheumatic disorders.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chloroquine; Female; Flufenamic Acid; Gold; Humans; Immunosuppression Therapy; Indomethacin; Injections, Intra-Articular; Male; Mefenamic Acid; Pentazocine; Phenacetin; Phenylbutazone; Prednisolone; Propionates | 1971 |
Aspirin and the kidney.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Humans; Kidney; Kidney Diseases; Kidney Papillary Necrosis; Nephritis, Interstitial; Phenacetin | 1971 |
Reactive metabolites of phenacetin and acetaminophen: a review.
Topics: Acetaminophen; Animals; Benzoquinones; Biotransformation; Cricetinae; Epoxy Compounds; Glucuronates; Glutathione; Hydroxylation; Imines; Microsomes, Liver; Phenacetin; Protein Binding; Rats; Sulfates | 1983 |
Nonprescription analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Drug Hypersensitivity; Gastrointestinal Diseases; Hearing Disorders; Hematologic Diseases; Humans; Kidney Diseases; Nonprescription Drugs; Phenacetin | 1983 |
The clinical significance of the effects of cigarette smoking on drug disposition.
Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin | 1983 |
Tobacco smoking and drugs: a clinically important interaction?
Topics: Acetaminophen; Animals; Dextropropoxyphene; Drug Interactions; Enzyme Induction; Glutethimide; Humans; Insulin; Lidocaine; Microsomes, Liver; Mixed Function Oxygenases; Pentazocine; Pharmaceutical Preparations; Phenacetin; Phenylbutazone; Propranolol; Smoking; Theophylline | 1984 |
Hepatotoxicity of mild analgesics.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Chemical and Drug Induced Liver Injury; Child; Humans; Phenacetin; Phenylbutazone; Salicylates | 1980 |
Mechanisms in the development of analgesic nephropathy.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Synergism; Humans; Kidney; Kidney Diseases; Kidney Papillary Necrosis; Phenacetin; Salicylates; Tissue Distribution | 1980 |
Phenacetin: an overview of its toxicity, metabolism and analysis.
Topics: Acetaminophen; Animals; Biotransformation; Humans; Liver; Phenacetin | 1981 |
Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents.
Topics: Acetaminophen; Acetanilides; Cytochrome P-450 Enzyme System; Oxidation-Reduction; Phenacetin | 1993 |
Habitual use of acetaminophen as a risk factor for chronic renal failure: a comparison with phenacetin.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Case-Control Studies; Drug Therapy, Combination; Humans; Kidney Failure, Chronic; Phenacetin; Risk Factors | 1996 |
Analgesic nephropathy.
Topics: Acetaminophen; Analgesics; Aspirin; Caffeine; Canada; Drug Combinations; Drug Synergism; Humans; Kidney Failure, Chronic; Phenacetin; Risk Factors; United States | 1998 |
Relationship between nonphenacetin combined analgesics and nephropathy: a review. Ad Hoc Committee of the International Study Group on Analgesics and Nephropathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Drug Combinations; Humans; Kidney Failure, Chronic; Phenacetin; Phosphodiesterase Inhibitors | 2000 |
18 trial(s) available for acetaminophen and phenacetin
| Article | Year |
|---|---|
Temporal variations in acetaminophen and phenacetin half-life in man.
Topics: 11-Hydroxycorticosteroids; Acetaminophen; Adult; Clinical Trials as Topic; Glucuronates; Half-Life; Humans; Male; Metabolic Clearance Rate; Oxidation-Reduction; Phenacetin; Time Factors | 1975 |
Analgesic use and chronic renal disease.
Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis; Aspirin; Chronic Disease; Dose-Response Relationship, Drug; Headache; Humans; Kidney Diseases; Middle Aged; Multicenter Studies as Topic; Phenacetin; Retrospective Studies; Risk Factors | 1989 |
Urinary enzyme excretion after a single dose of phenacetin and paracetamol (acetaminophen) during antidiuresis and during water diuresis.
Topics: Acetaminophen; Acetylglucosaminidase; beta-Galactosidase; Diuresis; Enzymes; gamma-Glutamyltransferase; Humans; Kidney; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Phenacetin; Random Allocation; Water | 1986 |
A comparative evaluation of marketed analgesic drugs.
Topics: Acetaminophen; Administration, Oral; Analgesics; Aspirin; Azepines; Clinical Trials as Topic; Codeine; Dextropropoxyphene; Evaluation Studies as Topic; Humans; Mefenamic Acid; Palliative Care; Pentazocine; Phenacetin; Placebos; Promazine | 1972 |
[Biological half-life of phenacetin and phenazone in man before and after treatment with phenobarbital].
Topics: Acetaminophen; Antipyrine; Clinical Trials as Topic; Half-Life; Humans; Male; Phenacetin; Phenobarbital | 1970 |
[EMA 3--a phenacetin-free combination with analgesic action].
Topics: Acetaminophen; Adult; Aged; Allyl Compounds; Analgesics; Barbiturates; Caffeine; Clinical Trials as Topic; Drug Combinations; Evaluation Studies as Topic; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Pain; Phenacetin; Thioridazine | 1973 |
Sedative properties of simple analgesics.
Topics: Acetaminophen; Adult; Aspirin; Clinical Trials as Topic; Diuresis; Humans; Hypnotics and Sedatives; Male; Phenacetin; Placebos; Sleep; Urinary Bladder; Urine | 1969 |
Treatment of dysmenorrhea. A comparative double blind study.
Topics: Acetaminophen; Adolescent; Adult; Amphetamine; Analgesics; Aspirin; Barbiturates; Clinical Trials as Topic; Dextropropoxyphene; Dysmenorrhea; Female; Humans; Middle Aged; Phenacetin | 1970 |
Controlled and uncontrolled studies on "Fiorinal-PA" for symptomatic relief in tension headache.
Topics: Acetaminophen; Aspirin; Barbiturates; Caffeine; Clinical Trials as Topic; Drug Synergism; Headache; Humans; Hypnotics and Sedatives; Phenacetin; Placebos | 1970 |
Effect of vasopressin on the reabsorption of phenacetin and its metabolites from the tubular fluid in man.
Topics: Acetaminophen; Aniline Compounds; Creatinine; Diuresis; Humans; Kidney Papillary Necrosis; Kidney Tubules; Phenacetin; Urea; Vasopressins | 1972 |
A comparison of acetophenetidin and acetaminophen. I. Analgesic effects in postpartum patients.
Topics: Acetaminophen; Analgesia; Aspirin; Clinical Trials as Topic; Female; Humans; Phenacetin; Placebos; Postoperative Care; Pregnancy; Puerperal Disorders; Statistics as Topic | 1967 |
A comparison of acetophenetidin and acetaminophen. II. Subjective effects in healthy volunteers.
Topics: Acetaminophen; Adult; Amphetamine; Aspirin; Barbiturates; Behavior; Central Nervous System; Clinical Trials as Topic; Humans; Male; Mental Processes; Phenacetin; Placebos; Statistics as Topic | 1967 |
Failure to detect increased elimination rate of phenacetin in man after treatment with phenobarbital.
Topics: Acetaminophen; Adult; Antipyrine; Humans; Male; Phenacetin; Phenobarbital; Time Factors | 1969 |
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffeine; Drug Synergism; Hand; Humans; Middle Aged; Osteoarthritis; Pain; Phenacetin; Placebos | 1970 |
[Effects of phenacetin and NAPAP on the blood picture of infants].
Topics: Acetaminophen; Erythrocytes; Humans; Infant; Infant, Newborn; Methemoglobin; Phenacetin | 1966 |
An evaluation of the analgesic efficacy of three opioid-analgesic combinations in postoperative oral surgery pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Codeine; Drug Combinations; Female; Humans; Hydrocodone; Male; Molar; Pain, Postoperative; Phenacetin | 1981 |
Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects.
Topics: Acetaminophen; Adult; Aged; Area Under Curve; China; Cytochrome P-450 CYP1A2; Enzyme Inhibitors; Female; Humans; Isoenzymes; Liver; Male; Middle Aged; Phenacetin; Plant Extracts; Random Allocation; Rosales; Time Factors | 1999 |
Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis.
Topics: Acetaminophen; Area Under Curve; Biotransformation; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cytochrome P-450 CYP1A2; Female; Half-Life; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Phenacetin; Predictive Value of Tests; Severity of Illness Index; Treatment Outcome | 2007 |
349 other study(ies) available for acetaminophen and phenacetin
| Article | Year |
|---|---|
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis | 1999 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Molecular Structure; Tumor Cells, Cultured | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.
Topics: Amino Acid Sequence; Ascomycota; Benzopyrans; Enzyme Inhibitors; Fungal Proteins; Melanins; Models, Molecular; Molecular Sequence Data; Oxidoreductases Acting on CH-CH Group Donors; Recombinant Proteins; Structural Homology, Protein; Substrate Specificity | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents.
Topics: 1-Octanol; Magnetic Resonance Spectroscopy; Pharmaceutical Preparations; Water | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.
Topics: Animals; Catalysis; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Escherichia coli; Fatty Acids, Unsaturated; Humans; Kinetics; Lidocaine; Mass Spectrometry; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; Phenacetin; Predictive Value of Tests; Serum Albumin, Bovine; Substrate Specificity | 2012 |
Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism.
Topics: Acetaminophen; Catalytic Domain; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Heme; Humans; Hydrogen Peroxide; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Phenacetin; Protein Binding; Protein Isoforms; Substrate Specificity | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A method for the estimation of acetanilide, paracetamol and phenacetin in plasma and urine using mass fragmentography.
Topics: Acetaminophen; Acetanilides; Chemical Phenomena; Chemistry; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Methods; Oxidation-Reduction; Phenacetin | 1976 |
The effect of waxes, hydrolysed gelatin and moisture on the compression characteristics of paracetamol and phenacetin.
Topics: Acetaminophen; Chemistry, Pharmaceutical; Gelatin; Hardness Tests; Humidity; Paraffin; Particle Size; Phenacetin; Pressure; Stearic Acids; Tablets; Waxes | 1976 |
Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Isotopes; Phenacetin; Phenobarbital | 1977 |
The kinetics of crystallisation of paracetamol and phenacetin from aqueous ethanol [proceedings].
Topics: Acetaminophen; Crystallization; Ethanol; Kinetics; Phenacetin; Water | 1977 |
Gastric erosions induced by analgesic drug mixtures in the rat.
Topics: Acetaminophen; Animals; Aspirin; Caffeine; Drug Combinations; Female; Lethal Dose 50; Phenacetin; Rats; Rats, Inbred Strains; Stomach Ulcer; Time Factors | 1978 |
The wetting of powders of acetylsalicylic acid, salicylic acid, phenacetin and paracetamol.
Topics: Acetaminophen; Aspirin; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Phenacetin; Powders; Salicylates; Surface Tension | 1978 |
Effects of phenacetin, paracetamol and caffeine on the erosive activity of acetylsalicylic acid in the rat stomach: dose-response relationships, time course of erosion development and effects on acid secretion.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Female; Gastric Juice; Gastric Mucosa; Male; Phenacetin; Rats; Sex Factors; Time Factors | 1979 |
Relation between regular intake of phenacetin-containing analgesics and laboratory evidence for urorenal disorders in a working female population of Switzerland.
Topics: Acetaminophen; Adult; Age Factors; Bacteriuria; Creatinine; Female; Hematuria; Humans; Kidney Diseases; Middle Aged; Occupational Medicine; Phenacetin; Proteinuria; Sex Factors; Specific Gravity; Specimen Handling; Switzerland; Time Factors | 1975 |
Polymorphism of carbon oxidation of drugs and clinical implications.
Topics: Acetaminophen; Carbon; Debrisoquin; Female; Guanidines; Humans; Hydroxylation; Male; Oxidation-Reduction; Phenacetin; Phenotype; Polymorphism, Genetic | 1978 |
[Current aspects of agranulocytosis (15 cases)].
Topics: Acetaminophen; Adult; Aged; Agranulocytosis; Ajmaline; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Bone Marrow Cells; Chloramphenicol; Female; Humans; Hyperbilirubinemia; Lymphocyte Activation; Middle Aged; Phenacetin; Transaminases | 1977 |
Hyperthermia, antipyretics and function of polymorphonuclear leukocytes.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Chemotaxis, Leukocyte; Fever; Humans; Neutrophils; Phenacetin; Salicylates; Staphylococcus aureus | 1978 |
Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Carrageenan; Cyclooxygenase Inhibitors; Inflammation; Male; Phenacetin; Prostaglandin Antagonists; Prostaglandins; Rats | 1977 |
Metabolic structure-activity relationship for a homologous series of phenacetin analogs.
Topics: Acetaminophen; Animals; Cricetinae; Dealkylation; Hydroxylation; In Vitro Techniques; Male; Mesocricetus; Mice; Mice, Inbred C57BL; Microsomes; Phenacetin; Structure-Activity Relationship | 1979 |
Inhibition of acetaminophen-induced hepatotoxicity by phenacetin and its alkoxy analogs.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Isocitrate Dehydrogenase; Liver; Male; Mice; Mice, Inbred C57BL; Phenacetin | 1979 |
The effects of paracetamol and other foreign compounds on protein synthesis in isolated adult rat hepatocytes [proceedings].
Topics: Acetaminophen; Acetanilides; Aniline Compounds; Animals; Cycloheximide; Dose-Response Relationship, Drug; In Vitro Techniques; Liver; Male; Phenacetin; Protein Biosynthesis; Rats; Safrole | 1979 |
Analgesic nephropathy. Epidemiological studies and pharmacological investigations.
Topics: Acetaminophen; Adult; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Microsomes; Middle Aged; Phenacetin; Phenetidine; Prospective Studies; Rats; Salicylates | 1979 |
Metabolism of [p-18O]-phenacetin: the mechanism of activation of phenacetin to reactive metabolites in hamsters.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cricetinae; Glutathione; Hydroxylation; In Vitro Techniques; Isotope Labeling; Male; Mesocricetus; Oxygen Isotopes; Phenacetin; Sulfates | 1979 |
Sequential first-pass elimination of a metabolite derived from a precursor.
Topics: Acetaminophen; Animals; Biological Availability; Kinetics; Liver; Phenacetin; Rats | 1979 |
N-Hydroxyacetaminophen: a microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Cricetinae; Hydroxylation; In Vitro Techniques; Microsomes, Liver; Phenacetin; Time Factors | 1979 |
Phenacetin concentrations in portal and hepatic venous blood in man.
Topics: Acetaminophen; Hepatic Veins; Humans; Phenacetin; Portal Vein; Time Factors | 1979 |
High-performance liquid chromatographic assay for acetaminophen and phenacetin in the presence of their metabolites in biological fluids.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Isotope Labeling; Methods; Phenacetin; Rats; Tritium | 1979 |
[Spectrophotometric method of paracetamol, phenacetin and acetarsol determination in pharmaceutical compounds].
Topics: Acetaminophen; Arsenicals; Phenacetin; Spectrophotometry | 1977 |
Liquid chromatographic analysis of analgesics on amberlite XAD-7.
Topics: Acetaminophen; Acrylic Resins; Analgesics; Aspirin; Caffeine; Chromatography, Liquid; Drug Combinations; Phenacetin; Polystyrenes; Salicylamides; Salicylates; Tablets | 1978 |
[Demonstration of phenacetin].
Topics: Acetaminophen; Humans; Kidney Diseases; Methods; Phenacetin | 1978 |
Nephropathies due to analgesics.
Topics: Acetaminophen; Analgesics; Humans; Kidney; Kidney Diseases; Kidney Medulla; Phenacetin; Salicylates | 1978 |
Formation of a thiomethyl metabolite of phenacetin and acetaminophen in dogs and man.
Topics: Acetaminophen; Adolescent; Adult; Animals; Biotransformation; Chromatography, Gas; Chromatography, Thin Layer; Dogs; Female; Humans; Hydrolysis; Male; Phenacetin | 1978 |
Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates.
Topics: Acetamides; Acetaminophen; Amino Acids; Animals; Chromatography, Thin Layer; Glucuronates; Glutathione; Half-Life; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; Phenacetin; Rats; Ribonucleosides; Sulfuric Acids | 1978 |
Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin.
Topics: Acetaminophen; Animals; Hydrolysis; Kinetics; Liver; Male; Metabolic Clearance Rate; Models, Biological; Perfusion; Phenacetin; Rats | 1978 |
Experimental renal papillary necrosis.
Topics: Acetaminophen; Animals; Aspirin; Body Weight; Drug Combinations; Female; Kidney Cortex; Kidney Medulla; Kidney Papillary Necrosis; Kidney Tubules, Collecting; Loop of Henle; Microscopy, Electron; Phenacetin; Rats | 1978 |
Analgesic-associated nephropathy in the U.S.A.: epidemiologic, clinical and pathogenetic features.
Topics: Acetaminophen; Adult; Aged; Analgesics; Animals; Aspirin; Creatinine; Drug Combinations; Female; Follow-Up Studies; Humans; Kidney Diseases; Middle Aged; Nephritis, Interstitial; Phenacetin; United States | 1978 |
Decreased toxicity of the N-methyl analogs of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Male; Mesocricetus; Methemoglobin; Methylation; Mice; Necrosis; Phenacetin | 1978 |
Metabolism of phenacetin and N-hydroxyphenacetin in isolated rat hepatocytes.
Topics: Acetaminophen; Animals; Female; Hydroxylation; In Vitro Techniques; Liver; Phenacetin; Rats; Time Factors | 1978 |
Kidney metabolism of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Biological Transport; Glutathione; Hippurates; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Medulla; Phenacetin; Rabbits | 1978 |
Stimulatory effect of brussels sprouts and cabbage on human drug metabolism.
Topics: Acetaminophen; Adult; Antipyrine; Biological Availability; Diet; Female; Humans; Male; Pharmaceutical Preparations; Phenacetin; Vegetables | 1979 |
[Relevance of enzyme histochemistry of rat thyroid gland].
Topics: Acetaminophen; Acid Phosphatase; Animals; Benzidines; Blood Proteins; Female; Histocytochemistry; Iodine; Iodine Radioisotopes; Leucyl Aminopeptidase; Male; Peroxidases; Phenacetin; Rats; Thyroid Gland | 1975 |
Acetaminophen production in man after coadministration of acetanilid and phenacetin. A study with stable isotopes.
Topics: Acetaminophen; Acetanilides; Chromatography, Gas; Deuterium; Drug Combinations; Humans; Hydroxylation; Male; Mass Spectrometry; Phenacetin; Time Factors | 1977 |
Quantitative determination of phenacetin and its metabolite acetaminophen by GLC-chemical ionization mass spectrometry.
Topics: Acetaminophen; Chromatography, Gas; Humans; Male; Mass Spectrometry; Methods; Phenacetin; Time Factors | 1977 |
Determination of acetaminophen and phenacetin in plasma by high-pressure liquid chromatography.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Colorimetry; Humans; Methods; Phenacetin | 1977 |
Some applications of bonded-phase high-performance liquid chromatography to the analysis of pharmaceutical formulations.
Topics: Acetaminophen; Aspirin; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Contamination; Guaifenesin; Hydroxybenzoates; Methods; Phenacetin; Phenylephrine; Phenylpropanolamine; Prednisolone; Prednisone; Tyrothricin | 1977 |
GLC microanalyses of phenacetin and acetaminophen plasma levels.
Topics: Acetaminophen; Adult; Chromatography, Gas; Humans; Methods; Microchemistry; Phenacetin | 1977 |
Production in vitro of paracetamol from phenacetin and [2H]acetanilide: a study with stable isotopes [proceedings].
Topics: Acetaminophen; Acetanilides; Animals; Deuterium; Isotope Labeling; Liver; Male; Phenacetin; Phenobarbital; Rats | 1977 |
Comparative metabolic studies of phenacetin and structurally-related compounds in the rat.
Topics: Acetaminophen; Acetanilides; Animals; Chromatography, Thin Layer; Female; Glucuronates; Male; Phenacetin; Rats; Sex Factors; Structure-Activity Relationship; Sulfuric Acids | 1976 |
[Dualwavelength in situ determination using zigzag scan (author's transl)].
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography, Thin Layer; Phenacetin | 1976 |
Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef.
Topics: Acetaminophen; Adult; Charcoal; Cooking; Diet; Female; Humans; Male; Meat; Phenacetin; Time Factors | 1976 |
Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Aspirin; Dinitrophenols; Female; Kidney Tubular Necrosis, Acute; Oxyphenbutazone; Phenacetin; Probenecid; Rats | 1976 |
Phenacetin and paracetamol.
Topics: Acetaminophen; Anemia, Hemolytic; Central Nervous System; Chemical Phenomena; Chemistry; Humans; Kidney Failure, Chronic; Methemoglobinemia; Phenacetin | 1976 |
The degradation of paracetamol (4-hydroxyacetanilide) and other substituted acetanilides by a Penicillium species.
Topics: Acetaminophen; Nicotinic Acids; Penicillium; Phenacetin; Phenetidine | 1975 |
Medical management of rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Arthritis, Rheumatoid; Aspirin; Cyclophosphamide; Exercise Therapy; Glucocorticoids; Gold; Humans; Indomethacin; Muscular Atrophy; Phenacetin; Phenylbutazone | 1976 |
Analgesic nephropathy.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Combinations; Female; Humans; Hypertension, Malignant; Kidney; Kidney Diseases; Kidney Papillary Necrosis; Male; Middle Aged; Nephritis, Interstitial; Phenacetin; Radiography; Substance-Related Disorders; Syndrome | 1976 |
Diseases causing end-stage renal failure in New South Wales.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Australia; Caffeine; Codeine; Cystoscopy; Female; Glomerulonephritis; Humans; Hypertension, Renal; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Phenacetin; Polycystic Kidney Diseases; Pyelonephritis; Renal Dialysis; Salicylamides; Salicylates; Transplantation, Homologous; Urography; Vesico-Ureteral Reflux | 1975 |
Analgesic abuse, ureteric obstruction, and retroperitoneal fibrosis.
Topics: Acetaminophen; Adult; Aged; Analgesia; Aspirin; Codeine; Female; Humans; Middle Aged; Phenacetin; Pregnancy; Retroperitoneal Fibrosis; Retrospective Studies; Ureter; Ureteral Obstruction | 1975 |
Selective colorimetric determination of paracetamot by means of an indophenol reaction.
Topics: Acetaminophen; Chemical Phenomena; Chemistry; Colorimetry; Hydrolysis; Indophenol; Oxidation-Reduction; Phenacetin | 1975 |
Effect of physical properties on compression characteristics.
Topics: Acetaminophen; Compliance; Elasticity; Hardness; Lactose; Particle Size; Phenacetin; Powders; Pressure; Tablets | 1975 |
The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Caffeine; Female; Heterozygote; Homozygote; Kidney Papillary Necrosis; Male; Phenacetin; Rats; Rats, Inbred Strains | 1975 |
On the pharmacokinetics of phenacetin in man.
Topics: Acetaminophen; Administration, Oral; Adult; Biological Availability; Dose-Response Relationship, Drug; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Mathematics; Metabolic Clearance Rate; Phenacetin; Tablets | 1975 |
Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents.
Topics: Acetaminophen; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carrageenan; Kaolin; Male; Models, Biological; Pain; Phenacetin; Pleurisy; Rats; Trypsin | 1976 |
Epidemiologic study of analgesic abuse: mortality study in 7275 working women (1968-1987).
Topics: Acetaminophen; Adult; Analgesics; Female; Humans; Longitudinal Studies; Middle Aged; Phenacetin; Prospective Studies; Salicylates; Salicylic Acid; Substance-Related Disorders; Switzerland | 1991 |
Combined assay for phenacetin and paracetamol in plasma using capillary column gas chromatography-negative-ion mass spectrometry.
Topics: Acetaminophen; Gas Chromatography-Mass Spectrometry; Humans; Ions; Phenacetin | 1991 |
[Analgesics and antipyretics in pediatrics].
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Humans; Phenacetin | 1991 |
Activity of phenacetin O-deethylase in rat liver: effect of inducers and inhibitors in vivo.
Topics: Acetaminophen; Aminophenols; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Hydrolysis; Liver; Male; Oxidoreductases; Phenacetin; Rats; Rats, Inbred Strains | 1991 |
Metabolism of paracetamol and phenacetin in relation to debrisoquine oxidation phenotype.
Topics: Acetaminophen; Adult; Biotransformation; Debrisoquin; Female; Humans; Male; Oxidation-Reduction; Phenacetin; Phenotype | 1991 |
Studies of paracetamol/phenacetin toxicity: isolation and characterization of p-aminophenol-glutathione conjugate.
Topics: Acetaminophen; Aminophenols; Animals; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Glutathione; Horseradish Peroxidase; Kidney; Magnetic Resonance Spectroscopy; Male; Microsomes; Microsomes, Liver; Oxidation-Reduction; Phenacetin; Rats; Rats, Inbred Strains | 1991 |
The risks of phenacetin use.
Topics: Acetaminophen; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Kidney Diseases; Phenacetin; Research Design; Substance-Related Disorders | 1991 |
Progression of renal insufficiency in analgesic nephropathy: impact of continuous drug abuse.
Topics: Acetaminophen; Adult; Aged; Analgesics; Austria; Creatinine; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phenacetin; Prognosis; Salicylates; Substance Abuse Detection; Substance-Related Disorders | 1991 |
Microbial models of mammalian metabolism: biotransformations of phenacetin and its O-alkyl homologues with Cunninghamella species.
Topics: Acetaminophen; Animals; Biotransformation; Chromatography; Mammals; Models, Biological; Mucorales; Phenacetin | 1990 |
Determination of the components of analgesic mixtures using high-performance thin-layer chromatography.
Topics: Acetaminophen; Analgesics; Antipyrine; Ascorbic Acid; Caffeine; Chromatography, High Pressure Liquid; Phenacetin; Phenylephrine | 1990 |
[Antipyretic analgesics derived from para-aminophenol].
Topics: Acetaminophen; Aminophenols; Chemical and Drug Induced Liver Injury; Kidney; Phenacetin | 1990 |
[Antipyretic action of aniline derivatives in rats during different parts of the day].
Topics: Acetaminophen; Animals; Circadian Rhythm; Fever; Male; Phenacetin; Phenetidine; Rats; Rats, Inbred Strains | 1990 |
[Epidemiological studies of the frequency of the abuse of analgesics].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Capillaries; Child; Child, Preschool; Female; Germany, West; Humans; Kidney Diseases; Kidney Pelvis; Male; Middle Aged; Phenacetin; Prevalence; Renal Dialysis; Sclerosis; Substance-Related Disorders | 1990 |
Effects of retrograde flow on measured blood volume, Disse space, intracellular water space and drug extraction in the perfused rat liver: characterization by the multiple indicator dilution technique.
Topics: Acetaminophen; Animals; Blood Volume; Body Water; Liver; Liver Circulation; Male; Phenacetin; Rats; Rats, Inbred Strains; Serum Albumin; Sucrose | 1990 |
Disposition of phenacetin in rabbits pretreated orally and intraperitoneally with 3,4-benzpyrene.
Topics: Acetaminophen; Administration, Oral; Animals; Benzo(a)pyrene; Enzyme Induction; Injections, Intraperitoneal; Liver; Male; Phenacetin; Rabbits | 1989 |
Analgesic use and chronic renal disease.
Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Data Collection; Humans; Kidney Diseases; Phenacetin | 1989 |
Progression of renal failure in analgesic-associated nephropathy.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Creatinine; Female; Humans; Kidney; Kidney Diseases; Longitudinal Studies; Male; Middle Aged; Phenacetin; Regression Analysis; Retrospective Studies | 1989 |
Analgesic nephropathy in West Germany.
Topics: Acetaminophen; Drug Therapy, Combination; Female; Germany, West; Humans; Kidney Diseases; Kidney Failure, Chronic; Phenacetin; Substance-Related Disorders | 1986 |
Metabolic basis of adverse drug reactions.
Topics: Acetaminophen; Acetylation; Adrenergic beta-Antagonists; Adult; Age Factors; Child; Debrisoquin; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Enzyme Inhibitors; Humans; Perhexiline; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenotype; Polymorphism, Genetic; Succinylcholine | 1986 |
Opiates in the restless legs syndrome.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Clonazepam; Dextropropoxyphene; Drug Combinations; Female; Humans; Male; Narcotics; Oxycodone; Phenacetin; Restless Legs Syndrome; Temazepam | 1987 |
The effects of acetaminophen, antipyrine and phenacetin on rat urothelial cell proliferation.
Topics: Acetaminophen; Animals; Antipyrine; Cell Division; Epithelial Cells; Epithelium; Hyperplasia; Kidney Pelvis; Male; Phenacetin; Rats; Rats, Inbred Strains; Urinary Bladder; Urologic Neoplasms | 1989 |
Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells.
Topics: Acetaminophen; Animals; Aspirin; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Cricetinae; Mice; Mice, Inbred C3H; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Phenacetin | 1989 |
Intestinal first-pass metabolism of phenacetin in rabbits pretreated orally and intraperitoneally with 3,4-benzpyrene.
Topics: Acetaminophen; Administration, Oral; Animals; Benzo(a)pyrene; Enzyme Induction; Injections, Intraperitoneal; Intestinal Mucosa; Intestine, Small; Mesenteric Veins; Phenacetin; Rabbits | 1989 |
An assay for paracetamol, produced by the O-deethylation of phenacetin in vitro, using gas chromatography/electron capture negative ion chemical ionization mass spectrometry.
Topics: Acetaminophen; Animals; Chemical Phenomena; Chemistry; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Microsomes, Liver; Phenacetin; Rats | 1986 |
Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.
Topics: Acetaminophen; Aminophenols; Electron Spin Resonance Spectroscopy; Free Radicals; In Vitro Techniques; Oxidation-Reduction; Peroxidases; Phenacetin; Phenetidine | 1986 |
Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique.
Topics: Acetaminophen; Animals; Body Fluids; Ethanol; In Vitro Techniques; Indicator Dilution Techniques; Intracellular Fluid; Liver; Liver Circulation; Male; Meperidine; Metabolic Clearance Rate; Perfusion; Pharmacokinetics; Phenacetin; Rats; Rats, Inbred Strains | 1988 |
The 3-methylcholanthrene-mimetic effect of 4,4'-dichlorobiphenyl-treatment on phenacetin-induced hepatic glutathione depletion and liver microsomal phenacetin O-deethylation in rats.
Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Glutathione; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenacetin; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1986 |
Combined hepatic arterial-portal venous and hepatic arterial-hepatic venous perfusions to probe the abundance of drug metabolizing activities: perihepatic venous O-deethylation activity for phenacetin and periportal sulfation activity for acetaminophen in
Topics: Acetaminophen; Algorithms; Animals; Hepatic Artery; Liver; Male; Perfusion; Phenacetin; Portal Vein; Rats; Rats, Inbred Strains; Sulfates | 1988 |
In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology.
Topics: Acetaminophen; Animals; Antipyrine; Biotransformation; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Oxidation-Reduction; Phenacetin; Rats; Triazoles | 1988 |
Does paracetamol cause urothelial cancer or renal papillary necrosis?
Topics: Acetaminophen; Carcinoma, Transitional Cell; Female; Humans; Kidney Neoplasms; Kidney Papillary Necrosis; Male; Middle Aged; New South Wales; Phenacetin; Retrospective Studies; Risk Factors; Surveys and Questionnaires; Ureteral Neoplasms; Urinary Bladder Neoplasms | 1988 |
The toxicology of non-narcotic analgesics.
Topics: Acetaminophen; Aminophenols; Analgesics; Animals; Biotransformation; Carcinogens; Dipyrone; Lethal Dose 50; Liver; Mutagens; Nitrites; Nitroso Compounds; Phenacetin; Pyrazoles; Pyrazolones; Rats; Salicylates | 1986 |
Mutagenicity testing of selected analgesics in Ames Salmonella strains.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Biotransformation; Ibuprofen; In Vitro Techniques; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Phenacetin; Rats; Salmonella typhimurium | 1986 |
Intestinal first-pass metabolism of phenacetin, acetaminophen, ethenzamide and salicylamide in rabbits pretreated with 3,4-benzo[a]pyrene.
Topics: Acetaminophen; Animals; Benzo(a)pyrene; In Vitro Techniques; Intestinal Absorption; Kinetics; Male; Phenacetin; Rabbits; Salicylamides | 1987 |
Species differences in cytotoxic and genotoxic effects of phenacetin and paracetamol in primary monolayer cultures of hepatocytes.
Topics: Acetaminophen; Animals; Cells, Cultured; Cricetinae; DNA; DNA Repair; Guinea Pigs; L-Lactate Dehydrogenase; Liver; Male; Mesocricetus; Mice; Phenacetin; Rats; Rats, Inbred Strains; Species Specificity; Trypan Blue | 1986 |
Analgesic use by leprosy patients.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Female; Humans; Kidney Papillary Necrosis; Leprosy; Male; Middle Aged; Nephritis, Interstitial; Phenacetin | 1986 |
Capillarosclerosis of the renal pelvis: autopsy study for estimating the incidence of phenacetin and paracetamol abuse.
Topics: Acetaminophen; Adult; Aged; Capillaries; Epidemiologic Methods; Female; Germany, West; Humans; Kidney Pelvis; Male; Middle Aged; Phenacetin; Prospective Studies; Sclerosis; Substance-Related Disorders; Vascular Diseases | 1986 |
A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.
Topics: Acetaminophen; Animals; Biological Availability; Biotransformation; Kinetics; Liver; Liver Circulation; Mathematics; Models, Biological; Pharmaceutical Preparations; Phenacetin | 1986 |
Relation of analgesic use to renal cancer: population-based findings.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Phenacetin; Retrospective Studies; Risk; Sex Factors; Surveys and Questionnaires | 1985 |
[Capillarosclerosis of the efferent urinary tract as an indication of analgesic abuse. Incidence in unselected autopsies in a large West German town].
Topics: Acetaminophen; Adult; Aged; Arteriosclerosis; Autopsy; Capillaries; Female; Humans; Kidney Pelvis; Male; Middle Aged; Phenacetin; Substance-Related Disorders | 1985 |
Heavy phenacetin use and bladder cancer in women aged 20 to 49 years.
Topics: Acetaminophen; Adult; Drug Combinations; Female; Humans; Middle Aged; New York; Phenacetin; Smoking; Substance-Related Disorders; Urinary Bladder Neoplasms | 1985 |
Alteration of drug metabolism by the use of prodrugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Biological Availability; Biotransformation; Drug Evaluation, Preclinical; Humans; Pharmaceutical Preparations; Phenacetin; Structure-Activity Relationship | 1985 |
Investigation of possible polymorphic drug oxidation in black South Africans.
Topics: Acetaminophen; Adult; Black People; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Phenacetin; Polymorphism, Genetic; South Africa; Time Factors | 1985 |
The metabolism of N-hydroxyphenacetin in vitro and in vivo.
Topics: Acetaminophen; Animals; Erythrocytes; Female; Guinea Pigs; In Vitro Techniques; Kinetics; Liver; Male; Methemoglobin; Phenacetin; Rabbits; Rats | 1985 |
Brown urine--a clue to phenacetin intoxication.
Topics: Acetaminophen; Chromatography, Thin Layer; Color; Humans; Phenacetin; Poisoning | 1970 |
Ultraviolet spectrophotometric analysis of barbiturates: evaluation of potential interferences.
Topics: Acetaminophen; Barbiturates; Chlorothiazide; Chlorpropamide; Dicumarol; Humans; Methods; Nicotinic Acids; Oxyphenbutazone; Phenacetin; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Salicylates; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Sulfinpyrazone; Sulfisoxazole; Theobromine; Theophylline; Warfarin | 1973 |
Effect of non-narcotic analgesics on anticoagulant-induced hypoprothrombinemia in rats.
Topics: Acetaminophen; Acetanilides; Administration, Oral; Animals; Antipyrine; Aspirin; Blood Coagulation; Dicumarol; Female; Hypoprothrombinemias; Injections, Intraperitoneal; Male; Phenacetin; Phenindione; Phenylbutazone; Rats; Salicylamides; Sodium Salicylate; Species Specificity; Time Factors; Warfarin | 1972 |
Community survey of analgesic consumption and kidney function in women.
Topics: Acetaminophen; Adult; Age Factors; Analgesics; Blood Pressure; Chronic Disease; Creatinine; Female; Humans; Kidney; Middle Aged; Phenacetin; Surveys and Questionnaires; Urea; Urinary Tract Infections | 1973 |
Metabolic rate of phenacetin and of paracetamol in dogs before and after treatment with phenobarbital or skf 525 A.
Topics: Acetaminophen; Animals; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dealkylation; Dialysis; Dogs; Half-Life; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Phenacetin; Phenazines; Phenobarbital; Proadifen; Proteins | 1974 |
Proceedings: The use oa a gelatin hydrolysate to improve the compressibility of paracetamol and phenacetin.
Topics: Acetaminophen; Drug Compounding; Gelatin; Pharmaceutic Aids; Phenacetin; Pressure; Tablets | 1974 |
Effect of anti-inflammatory agents on platelets.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Codeine; Dextropropoxyphene; Gentisates; Humans; Indomethacin; ortho-Aminobenzoates; Oxyphenbutazone; Phenacetin; Phenylacetates; Phenylbutazone; Sodium Salicylate | 1968 |
Phenacetin.
Topics: Acetaminophen; Antipyrine; Denmark; Humans; Kidney Diseases; Kidney Neoplasms; Kidney Papillary Necrosis; Legislation, Drug; Phenacetin; Pyelonephritis; Salicylates; Substance-Related Disorders; Sweden; Switzerland; Urinary Bladder Neoplasms | 1969 |
Central effects of simple analgesic drugs.
Topics: Acetaminophen; Analgesics; Aspirin; Humans; Hypnotics and Sedatives; Phenacetin; Sleep; Urinary Bladder | 1970 |
[Kidney toxicity of analgesics].
Topics: Acetaminophen; Administration, Oral; Aspirin; Humans; Kidney Diseases; Long-Term Care; Phenacetin | 1973 |
The effects of some anti-inflammatory agents on the urinary excretion of acid mucopolysaccharides in the rat.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Connective Tissue; Glycosaminoglycans; Hexosamines; Nitrogen; Phenacetin; Phenylbutazone; Rats; Uronic Acids | 1967 |
[Differences between the protein binding of newborns and adults and their importance for pharmacological action].
Topics: Acetaminophen; Age Factors; Aminosalicylic Acids; Atropine; Chloramphenicol; Humans; Infant, Newborn; Isoniazid; Methicillin; Morphine; Nitrofurantoin; Oxyphenbutazone; Phenacetin; Phenobarbital; Phenytoin; Promethazine; Protein Binding; Salicylates; Sulfadimethoxine; Thiopental | 1968 |
[Sensitization to phenacetin: immunological aspects].
Topics: Acetaminophen; Adult; Aniline Compounds; Biopsy; Cells, Cultured; Drug Eruptions; Drug Hypersensitivity; Ethyl Ethers; Female; Humans; Lymphocyte Activation; Phenacetin; Skin; Skin Tests | 1973 |
Proceedings: Hepatotoxicity and metabolism of paracetamol in rats and mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous; Liver; Mice; Phenacetin; Rats; Species Specificity | 1974 |
Proceedings: Isolated tubuli of kidneys as a model of pharmacological investigations.
Topics: Acetaminophen; Animals; Gluconeogenesis; Glutathione; In Vitro Techniques; Kidney Tubules; Methods; Nitriles; Organophosphorus Compounds; Phenacetin; Phenols; Potassium Chloride; Rats; Sarin | 1974 |
Hydroxylation of phenacetin by beagle liver microsomes.
Topics: Acetaminophen; Animals; Benzopyrenes; Dealkylation; Dogs; Hydroxylation; Kinetics; Microsomes, Liver; Phenacetin; Phenobarbital; Proadifen | 1974 |
Studies of the mode of action of the sulfonylureas and phenylacetamides in enhancing the effect of vasopressin.
Topics: Acetaminophen; Adenylyl Cyclase Inhibitors; Animals; Bufo marinus; Chlorpropamide; Cyclic AMP; Drug Synergism; In Vitro Techniques; Osmosis; Phenacetin; Phosphoric Monoester Hydrolases; Prostaglandins; Stimulation, Chemical; Sulfonylurea Compounds; Theophylline; Tritium; Urinary Bladder; Vasopressins; Water | 1972 |
[Comparative study on quantitative determination of mixtures of analgesics. 1. Studies on selectivity of volumetric analysis procedures].
Topics: Acetaminophen; Aminopyrine; Analgesics; Ascorbic Acid; Aspirin; Barbiturates; Caffeine; Chlorpromazine; Codeine; Conductometry; Electrochemistry; Meprobamate; Mesylates; Methods; Papaverine; Phenacetin; Phenobarbital; Phenylbutazone; Potentiometry; Quinine; Salicylamides; Salicylates; Theobromine | 1974 |
A limit test for p-chloroacetanilide and other impurities in paracetamol and phenacetin using thin-layer chromatography.
Topics: Acetaminophen; Acetanilides; Chemistry, Pharmaceutical; Chromatography, Thin Layer; Phenacetin | 1965 |
The nephrotoxicity of analgesics.
Topics: Acetaminophen; Aspirin; Caffeine; Erythrocytes; Female; Humans; Kidney; Kidney Tubules; Leukocytes; Male; Nephritis; Phenacetin | 1966 |
[Studies on the mechanism of hydroxylation and oxidative O-dealkylation of phenacetin in model systems].
Topics: Acetaminophen; Edetic Acid; Free Radicals; Hydroxides; Iron; Microsomes; Mixed Function Oxygenases; Models, Chemical; NAD; NADP; Phenacetin | 1967 |
[Metabolism of phenacetin and p-phenetidine in the kidney].
Topics: Acetaminophen; Aniline Compounds; Animals; Kidney; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenacetin; Rabbits | 1969 |
[Record of the utilization in otorhinolaryngology of an anticongestive, anti-inflammatory and analgesic combination effective by oral route (180 clinical cases)].
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Drug Synergism; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Otorhinolaryngologic Diseases; Phenacetin; Phenylpropanolamine | 1968 |
Physico-chemical studies of analgesics. The protein-binding of some p-substituted acetanilides.
Topics: Acetaminophen; Acetanilides; Analgesics; Chemical Phenomena; Chemistry, Physical; Dialysis; Hydrogen-Ion Concentration; Phenacetin; Protein Binding; Serum Albumin, Bovine; Water | 1970 |
The gas-liquid chromatographic estimation of phenacetin and paracetamol in plasma and urine.
Topics: Acetaminophen; Anilides; Chromatography, Gas; Indicators and Reagents; Methods; Phenacetin; Silicon | 1971 |
Estimation of phenacetin and paracetamol in plasma and urine by gas-liquid chromatography.
Topics: Acetaminophen; Chromatography, Gas; Methods; Phenacetin | 1972 |
Quantitative analysis of a multicomponent analgesic product containing butalbital, using high speed reverse-phase liquid chromatography.
Topics: Acetaminophen; Allyl Compounds; Analgesics; Aspirin; Barbiturates; Caffeine; Chromatography; Drug Combinations; Phenacetin; Tablets | 1974 |
Editorial: The pursuit of a chimera.
Topics: Acetaminophen; Animals; Aspirin; Barbiturates; Chloroform; Dogs; Drug-Related Side Effects and Adverse Reactions; Humans; Phenacetin; Thalidomide; Trichloroethylene; Tubocurarine | 1974 |
[Clinical pharmacology of common analgesics, narcotics and sedatives (tranquilizers)].
Topics: Acetaminophen; Analgesics; Aspirin; Barbiturates; Chloral Hydrate; Diazepam; Drug Synergism; Humans; Hypnotics and Sedatives; Limbic System; Meprobamate; Phenacetin; Phenobarbital; Salicylates; Secobarbital; Tranquilizing Agents | 1972 |
Regulations controlling the sale of mild analgesics in Canada.
Topics: Acetaminophen; Analgesics; Canada; Drug and Narcotic Control; Drug Prescriptions; Humans; Kidney Failure, Chronic; Phenacetin; Substance-Related Disorders | 1972 |
Effect of vasopressin on the renal tubular reabsorption and cortico-papillary concentration gradient of phenacetin and its metabolites.
Topics: Acetaminophen; Animals; Dogs; Female; Kidney; Kidney Concentrating Ability; Kidney Cortex; Kidney Tubules; Phenacetin; Urea; Vasopressins | 1972 |
[Effect of N-acetyl-p-aminophenol sulfate in augmenting the analgesic effect and acute toxicity of aminopyrine].
Topics: Acetaminophen; Administration, Oral; Aminopyrine; Animals; Aspirin; Drug Synergism; Male; Mice; Morphine; Phenacetin; Sulfates | 1972 |
The short-term effects of analgesics on the kidney with special reference to acetylsalicylic acid.
Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Animals; Aspirin; Caffeine; Dose-Response Relationship, Drug; Drug Combinations; Female; Kidney Cortex; Kidney Tubules; Male; Nephrons; Phenacetin; Rats; Regeneration; Time Factors | 1973 |
Separation of morphine alkaloids, heroin, methadone and other drugs by ion-exchange chromatography.
Topics: Acetaminophen; Aspirin; Autoanalysis; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Heroin; Methadone; Methods; Morphine; Opium; Phenacetin; Solvents | 1973 |
Clinical toxicology. VII. Poisoning by salicylates, paracetamol, tricyclic antidepressants and a miscellany of drugs.
Topics: Acetaminophen; Adult; Amphetamine; Antidepressive Agents; Caustics; Digitalis; Fenfluramine; Humans; Male; Monoamine Oxidase Inhibitors; Phenacetin; Plants, Medicinal; Plants, Toxic; Poisoning; Salicylates | 1973 |
Influence of complex formation on drug release from tablets.
Topics: Acetaminophen; Dialysis; Drug Compounding; Glycols; Lactose; Particle Size; Pharmaceutic Aids; Pharmaceutical Preparations; Phenacetin; Polyethylenes; Povidone; Solubility; Spectrophotometry, Ultraviolet; Sulfamethazine; Sulfisoxazole; Tablets; Time Factors; Viscosity | 1973 |
[Risks in long-term treatment with analgesics].
Topics: Acetaminophen; Analgesics; Antipyrine; Aspirin; Caffeine; Diuresis; Drug Combinations; Humans; Kidney Diseases; Mental Disorders; Phenacetin; Substance-Related Disorders | 1973 |
Analgesic nephropathy associated with paracetamol.
Topics: Acetaminophen; Codeine; Female; Headache; Humans; Kidney Diseases; Middle Aged; Nausea; Phenacetin; Self Medication; Vomiting | 1973 |
Effect of cigarette smoking on phenacetin metabolism.
Topics: Acetaminophen; Adult; Animals; Benzopyrenes; Carbon Radioisotopes; Chromatography, Thin Layer; Dealkylation; Female; Humans; Intestinal Mucosa; Male; Phenacetin; Rats; Smoking; Stimulation, Chemical; Time Factors | 1974 |
[Non-narcotic analgesics (antipyretic analgesics, codeine, propoxyphene)].
Topics: Acetaminophen; Analgesics; Codeine; Dextropropoxyphene; Flufenamic Acid; Glycols; Indomethacin; Mefenamic Acid; ortho-Aminobenzoates; Phenacetin; Phenylpropionates; Pyrazoles; Quinolines; Salicylates | 1974 |
The immunogenicity of phenacetin and some of its metabolites in guinea pigs.
Topics: Acetaminophen; Administration, Oral; Aniline Compounds; Animals; Antigens; Cells, Cultured; Dermatitis, Contact; Desensitization, Immunologic; Ethyl Ethers; Female; Guinea Pigs; Hypersensitivity, Delayed; Immune Tolerance; Injections, Intravenous; Lymphocyte Activation; Lymphocytes; Phenacetin; Skin Tests | 1974 |
A colorimetric method for the determination of phenacetin and paracetamol. 3. Studies of the indophenol reaction: an alternative manual procedure for the determination of phenacetin and paracetamol and its application to the determination of other pharmac
Topics: Acetaminophen; Chemical Phenomena; Chemistry; Colorimetry; Hydrogen-Ion Concentration; Indophenol; Manuals as Topic; Methods; Phenacetin; Procaine; Sulfonamides; Temperature | 1974 |
Aspirin and the kidney. New Zealand Rheumatism Association Study.
Topics: Acetaminophen; Adult; Arthritis, Rheumatoid; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Humans; Kidney Diseases; Male; Middle Aged; New Zealand; Osteoarthritis; Phenacetin; Phenylbutazone; Salicylates; Urinary Tract Infections | 1974 |
Editorial: Choice of a mild analgesic.
Topics: Acetaminophen; Aspirin; Drug Combinations; Humans; Kidney Diseases; Phenacetin; Substance-Related Disorders | 1974 |
Effect of chronic administration of analgesics on resistance to experimental infection of the urinary tract in rats.
Topics: Acetaminophen; Animals; Aspirin; Bacteriuria; Escherichia coli Infections; Female; Foreign Bodies; Kidney Diseases; Male; Phenacetin; Rats; Urinary Tract Infections | 1968 |
Analgetic drugs--the mild analgetics.
Topics: Acetaminophen; Acetanilides; Administration, Oral; Analgesics; Aspirin; Codeine; Dextropropoxyphene; Hemorrhage; Humans; Indomethacin; Morphinans; Pain; Phenacetin; Phenylbutazone; Substance-Related Disorders | 1972 |
General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat.
Topics: Acetaminophen; Anemia, Macrocytic; Anilides; Animals; Blood; Blood Glucose; Body Weight; Caffeine; Depression, Chemical; Diuresis; Feeding Behavior; Glomerular Filtration Rate; Growth; Kidney; Male; Mercaptopurine; Methemoglobinemia; Phenacetin; Rats; Urea; Urine | 1972 |
Antipyretics.
Topics: Acetaminophen; Analgesics; Aspirin; Child; Health Education; Humans; Indomethacin; Mefenamic Acid; Pediatrics; Phenacetin; Salicylamides; Seizures; Substance-Related Disorders | 1972 |
The effect of acetylsalicylic acid, caffeine, and codeine on the excretion of phenacetin metabolites.
Topics: Acetaminophen; Aniline Compounds; Aspirin; Caffeine; Chromatography, Thin Layer; Codeine; Creatinine; Ethyl Ethers; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Phenacetin; Time Factors; Tritium | 1972 |
A colorimetric method for the determination of phenacetin and paracetamol. I. An automated procedure for the determination, in formulations, of phenacetin and paracetamol alone or in the presence of aspirin and codeine phosphate.
Topics: Acetaminophen; Aspirin; Autoanalysis; Codeine; Colorimetry; Drug Combinations; Drug Compounding; Methods; Phenacetin | 1972 |
A colorimetric method for the determination of phenacetin and paracetamol. II. A manual procedure for the determination of phenacetin or paracetamol in formulations.
Topics: Acetaminophen; Aspirin; Codeine; Colorimetry; Drug Compounding; Methods; Phenacetin | 1972 |
Decreased concentration of phenacetin in plasma of cigarette smokers.
Topics: Acetaminophen; Administration, Oral; Adult; Chromatography, Gas; Female; Humans; Male; Phenacetin; Smoking; Time Factors | 1972 |
In vitro effect of anti-inflammatory agents on phagocytosis and bacterial killing by human neutrophilic leukocytes.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Depression, Chemical; Humans; Hydrocortisone; Indomethacin; Mefenamic Acid; Neutrophils; Phagocytosis; Phenacetin; Phenylbutazone; Staphylococcus; Stimulation, Chemical | 1972 |
[Dialysis of drugs and poisons. 2].
Topics: Acetaminophen; Aminopyrine; Amitriptyline; Aspirin; Carbamazepine; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Heroin; Humans; Imipramine; Lithium; Pargyline; Pentazocine; Phenacetin; Phenelzine; Phenytoin; Poisoning; Primidone; Promazine; Renal Dialysis; Salicylates; Tranylcypromine; Trifluoperazine | 1972 |
100-day LD 50 index of chronic toxicity.
Topics: Acetaminophen; Administration, Oral; Animals; Aspirin; Atropine; Caffeine; DDT; Drug-Related Side Effects and Adverse Reactions; Intubation, Gastrointestinal; Lethal Dose 50; Penicillin G; Phenacetin; Pilocarpine; Rats; Sodium Chloride; Sucrose; Time Factors | 1971 |
Haemoglobinuria in Nigerian children.
Topics: Acetaminophen; Aspirin; Autopsy; Brain; Caffeine; Child; Child, Preschool; Coombs Test; Diagnosis, Differential; Erythrocytes; Female; Genotype; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Hemoglobinuria; Humans; Infant; Kidney; Liver; Malaria; Male; Nigeria; Phenacetin; Quinine; Sex Factors; Spleen; Sulfonamides | 1971 |
GLC analysis of multicomponent suppository formulations.
Topics: Acetaminophen; Amides; Aminopyrine; Aspirin; Benzoates; Caffeine; Chlorpheniramine; Chromatography, Gas; Dextropropoxyphene; Ethylamines; Lidocaine; Malonates; Phenacetin; Sulfadimethoxine; Suppositories | 1971 |
The analysis of aspirin and related compounds by liquid chromatography.
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography, Ion Exchange; Computers; Methods; Phenacetin; Salicylamides | 1971 |
Acetaminophen, valadol, and analgesic renal injury.
Topics: Acetaminophen; Analgesics; Aspirin; Humans; Kidney Diseases; Kidney Papillary Necrosis; Nephritis, Interstitial; Phenacetin; Pyelonephritis | 1971 |
["Phenacetin-kidney" or "analgetic-nephropathy"].
Topics: Acetaminophen; Aspirin; Humans; Kidney Diseases; Phenacetin | 1971 |
Inhibitory effects of some anti-inflammatory and other analgesics and nitrofurans on the induction of -galactosidase synthesis in Klebsiella aerogenes.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Aspirin; Enzyme Induction; Furazolidone; Galactosidases; Klebsiella; Morphine; Nalorphine; Niridazole; Nitrofurans; Nitrofurantoin; Nitrofurazone; Phenacetin; Salicylamides; Salicylates | 1971 |
[Determination and elimination of N-acetyl-p-aminophenol depending on kidney function following administration of phenacetin].
Topics: Acetaminophen; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Male; Phenacetin | 1967 |
Fever responses to bacterial pyrogens in guinea pigs and application for screening of antipyretic agents.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Body Temperature; Female; Fever; Flufenamic Acid; Guinea Pigs; Indomethacin; Injections, Intravenous; Lipopolysaccharides; Phenacetin; Phenylbutazone; Polysaccharides, Bacterial; Pseudomonas; Pyrogens; Quinine; Typhoid-Paratyphoid Vaccines | 1968 |
Generic inequivalence--clinical observations.
Topics: Absorption; Acetaminophen; Administration, Oral; Adult; Aspirin; Biopharmaceutics; Capsules; Chloramphenicol; Delayed-Action Preparations; Drug Compounding; Female; Humans; Hydrochlorothiazide; Phenacetin; Prednisone; Tablets; Tablets, Enteric-Coated; Tetracycline; Therapeutic Equivalency; Time Factors; Tolbutamide; Triamterene | 1971 |
[The hazards of phenacetin and other analgesics].
Topics: Acetaminophen; Analgesics; Humans; Kidney Diseases; Phenacetin; Self Medication; Substance-Related Disorders | 1969 |
[Experimental increase of lipofuscin in the rat].
Topics: Acetaminophen; Aminopyrine; Animals; Aspirin; Centrifugation, Density Gradient; Cytoplasmic Granules; Ferritins; Kidney; Lipid Metabolism; Liver; Male; Membranes; Microscopy, Electron; Phenacetin; Pigments, Biological; Rats; Spectrum Analysis; Time Factors | 1969 |
[Demonstration of paracetamol in the urine following ingestion of therapeutic doses of phenacetin-containing analgesics].
Topics: Acetaminophen; Adult; Chemistry, Clinical; Chromatography, Thin Layer; Female; Humans; Male; Phenacetin; Silver Nitrate; Spectrophotometry | 1969 |
[New aspects on the question of phenacetin nephrotoxicity].
Topics: Acetaminophen; Aniline Compounds; Animals; Humans; Kidney; Kidney Diseases; Phenacetin; Rats | 1969 |
Analgesic nephropathy. A common form of renal disease in Australia.
Topics: Acetaminophen; Analgesics; Anemia; Animals; Aspirin; Australia; Caffeine; Diagnosis, Differential; Drug and Narcotic Control; Drug Synergism; Drug Utilization; Female; Humans; Kidney Function Tests; Kidney Papillary Necrosis; Nephritis, Interstitial; Phenacetin; Radiography; Substance-Related Disorders; Uremia | 1969 |
Surface area measurements in compressed powder systems.
Topics: Acetaminophen; Dosage Forms; Glucose; Phenacetin; Powders; Surface Properties; Water | 1970 |
Phenacetin nephropathy.
Topics: Acetaminophen; Adult; Humans; Kidney Diseases; Male; Middle Aged; Phenacetin | 1970 |
Phenacetin nephropathy, with particular reference to the effect of surgery.
Topics: Acetaminophen; Adult; Creatinine; England; Female; Hematuria; Humans; Hypertension, Renal; Kidney Diseases; Kidney Failure, Chronic; Kidney Function Tests; London; Male; Middle Aged; Phenacetin; Postoperative Complications; Scotland; Urinary Tract Infections; Urography; Wales | 1970 |
[Abuse of phenacetin-containing analgesics--kidney pelvis neoplasms].
Topics: Acetaminophen; Drug Synergism; Humans; Kidney Neoplasms; Phenacetin | 1970 |
Phenacetin nephropathy.
Topics: Acetaminophen; Animals; Aspirin; Caffeine; Humans; Kidney Diseases; Phenacetin; Rats | 1970 |
The effects of moisture on the flow properties and compression of phenacetin, paracetamol and dextrose monohydrate.
Topics: Acetaminophen; Densitometry; Glucose; Humans; Humidity; Phenacetin; Solubility; Tablets; Technology, Pharmaceutical | 1970 |
[Use and misuse of light analgetics for headache].
Topics: Acetaminophen; Antipyrine; Aspirin; Dextropropoxyphene; Headache; Humans; Phenacetin; Salicylamides; Substance-Related Disorders | 1971 |
Differentiation of urinary N-acetyl-p-aminophenol from endogenous phenolic compounds.
Topics: Acetaminophen; Analgesics; Child, Preschool; Chromatography, Gas; Chromatography, Paper; Female; Humans; Methods; Phenacetin; Phenols; Spectrum Analysis; Ultraviolet Rays | 1971 |
Selective colorimetric determination of acetaminophen.
Topics: Acetaminophen; Colorimetry; Delayed-Action Preparations; Ethylamines; Methods; Nitrites; Phenacetin; Salicylamides; Spectrophotometry; Tablets | 1971 |
Comparative systemic availability of acetaminophen when administered orally as such and as acetophenetidin.
Topics: Acetaminophen; Administration, Oral; Biopharmaceutics; Humans; Phenacetin | 1971 |
[Detection and excretion of N-acetyl-p-aminophenol in relation to kidney function after phenacetin ingestion].
Topics: Acetaminophen; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases; Metabolic Clearance Rate; Phenacetin | 1967 |
[Demonstration and determination of phenacetin, N-acetyl-p-aminophenol and their prinicipal conversion products in urine and serum].
Topics: Acetaminophen; Animals; Chromatography, Thin Layer; Methods; Phenacetin; Rats | 1967 |
[Analysis of mixed drugs by mass spectrometry. VII. Analysis of antifebrile. 3. High-resolution mass spectra of phenacetin, pyrinazine and 4-aminosalicylic acid].
Topics: Acetaminophen; Aminosalicylic Acids; Chemical Phenomena; Chemistry; Phenacetin; Spectrum Analysis | 1967 |
Chromatographic methods for analysis of the metabolites of acetophenetidin (phenacetin).
Topics: Acetaminophen; Amino Alcohols; Animals; Chromatography, Gas; Chromatography, Thin Layer; Dogs; Humans; Infrared Rays; Meperidine; Phenacetin; Phenols; Spectrophotometry | 1968 |
Analgesic abuse: maximal tolerated daily doses of acetylsalicylic acid.
Topics: Acetaminophen; Acids; Analgesics; Animals; Appetite; Aspirin; Brain; Caffeine; Growth; Humans; Phenacetin; Rats; Substance-Related Disorders; Thirst; Water | 1968 |
[Thin layer chromatographic demonstration of acetanilide and some chemically related analgesics].
Topics: Acetaminophen; Acetanilides; Analgesics; Chromatography, Thin Layer; Methods; Phenacetin | 1968 |
[Absorption, destination and excretion of phenacetin and N-acetyl-p-aminophenol in renal insufficiency].
Topics: Acetaminophen; Adult; Creatinine; Female; Humans; Intestinal Absorption; Kidney; Kidney Failure, Chronic; Male; Phenacetin | 1968 |
The analgetic properties of m-trifluoromethyl acetanilide.
Topics: Acetaminophen; Acetanilides; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Carrageenan; Cats; Codeine; Dextropropoxyphene; Dogs; Methemoglobin; Pain; Phenacetin; Phenylbutazone; Rats; Serotonin Antagonists | 1968 |
Interactions between pharmaceutical compounds by thermal methods.
Topics: Acetaminophen; Aspirin; Atropine; Bile Acids and Salts; Caffeine; Drug Compounding; Drug Incompatibility; Drug Stability; Methods; Phenacetin; Phenobarbital; Phenytoin; Quinine; Temperature; Theophylline; Thermodynamics; Time Factors; Vitamin K | 1969 |
Additive and augmentative synergism between analgesic drugs.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Caffeine; Codeine; Dextropropoxyphene; Drug Synergism; Hydroxyzine; Meprobamate; Mice; Phenacetin | 1965 |
[Pharmacological and toxicological studies of a new analgesic and antiphlogistic agent, 2-(2-methoxy-ethoxy)-5-acetaminoacetophenone].
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Cats; In Vitro Techniques; Phenacetin; Rats | 1965 |
Effect on vasopressin action of analgesic drugs in vitro.
Topics: Acetaminophen; Animals; Anura; Biological Transport; Cell Membrane; Drug Synergism; In Vitro Techniques; Phenacetin; Salicylates; Vasopressins; Water | 1966 |
Liver necrosis from paracetamol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Organ Size; Phenacetin; Rats | 1966 |
The metabolism of acetophenetidin and N-acetyl-p-aminophenol in the cat.
Topics: Acetaminophen; Animals; Cats; Chromatography; Dogs; Glucuronates; Liver; Male; Methemoglobinemia; Methylcholanthrene; Phenacetin; Rats | 1966 |
[Determination of phenacetin and n-acetyl-p-aminophenol as metabolites in urine].
Topics: Acetaminophen; Ammonia; Chromatography, Thin Layer; Humans; Methods; Phenacetin; Solvents; Spectrophotometry | 1966 |
[p-Aminophenol determination in urine as a routine method for detection of phenacetin intake].
Topics: Acetaminophen; Adult; Aged; Female; Humans; Male; Middle Aged; Phenacetin | 1967 |
Paracetamol and the kidney.
Topics: Acetaminophen; Adult; Cystoscopy; Humans; Kidney Papillary Necrosis; Male; Phenacetin; Urography | 1967 |
[Metabolic transformation of phenacetin and N-acetyl-p-aminophenol after pretreatment with phenobarbital].
Topics: Acetaminophen; Animals; Phenacetin; Phenobarbital; Rats | 1967 |
Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilate: oxygenation or electron transfer?
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Electron Transport; Oxidation-Reduction; Phenacetin; Salicylates | 1981 |
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infarction; Myocardium; Necrosis; Phenacetin; Polyarteritis Nodosa; Rats; Rats, Inbred Strains; Splanchnic Circulation | 1981 |
Clinical assessment of the renal toxicity of antirheumatic drugs.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dinoprostone; Humans; Ibuprofen; Kidney Diseases; Kidney Function Tests; Phenacetin; Prostaglandins; Prostaglandins E | 1984 |
History of antipyretic analgesic therapy.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; History, 19th Century; History, 20th Century; History, Ancient; History, Medieval; Humans; Phenacetin; Pyrazoles; Salicylates | 1983 |
Inhibition of prostaglandin synthetases derived from neuronal and glial cells and rat renal medulla by ortho-, meta- and para-substituted aminophenolic compounds.
Topics: Acetaminophen; Aminophenols; Animals; Aspirin; Astrocytoma; Cell Line; Clone Cells; Cyclooxygenase Inhibitors; Kidney Medulla; Male; Mice; Neuroblastoma; Phenacetin; Phenetidine; Rats; Structure-Activity Relationship | 1983 |
Decreasing inhibitory potency of prostaglandin synthetase inhibitors during their cooxidative metabolism. Studies on aminophenols, pyrazolon derivatives and 1,3-diphenylisobenzofuran.
Topics: Acetaminophen; Aminophenols; Aminopyrine; Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Cyclooxygenase Inhibitors; Diclofenac; Indomethacin; Kidney Medulla; Lipoxygenase Inhibitors; Male; Peroxides; Phenacetin; Phenylbutazone; Rats; Rats, Inbred Strains | 1983 |
Drug metabolism in Indian childhood cirrhosis.
Topics: Acetaminophen; Child, Preschool; Humans; Infant; Kinetics; Liver Cirrhosis; Phenacetin | 1984 |
Combination analgesics.
Topics: Acetaminophen; Analgesics; Aspirin; Caffeine; Codeine; Dextropropoxyphene; Drug Interactions; Drug Therapy, Combination; Humans; Hydrocodone; Narcotics; Oxycodone; Phenacetin; Primary Health Care; Tranquilizing Agents | 1984 |
The abuse of analgesics leading to nephropathy in South Africa.
Topics: Acetaminophen; Analgesics; Aspirin; Female; Humans; Kidney Failure, Chronic; Male; Phenacetin | 1984 |
The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition.
Topics: Acetaminophen; Adult; Dealkylation; Debrisoquin; Female; Humans; Hydroxylation; Male; Oxidation-Reduction; Phenacetin; Phenotype; Time Factors | 1983 |
Presumed analgesic-induced agranulocytosis.
Topics: Acetaminophen; Agranulocytosis; Analgesics; Aspirin; Dipyrone; Humans; Phenacetin | 1983 |
Intragastric self-administration in the rhesus monkey: a comparison of the reinforcing effects of codeine, phenacetin and paracetamol.
Topics: Acetaminophen; Animals; Codeine; Dose-Response Relationship, Drug; Haplorhini; Humans; Individuality; Intestinal Absorption; Macaca mulatta; Male; Phenacetin; Reinforcement, Psychology; Stomach; Substance Withdrawal Syndrome | 1980 |
Nephrotoxicity of mild analgesics in the Gunn strain of rat.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Glucuronosyltransferase; Kidney Diseases; Kidney Medulla; Mutation; Phenacetin; Rats | 1980 |
[Weighing the risk of weakly active analgesics. Paraminophenol and pyrazole derivatives. Conclusion].
Topics: Acetaminophen; Humans; Pain; Phenacetin; Pyrazoles; Risk | 1982 |
Inhibitory actions of desacetylation products of phenacetin and paracetamol on prostaglandin synthetases in neuronal and glial cell lines and rat renal medulla.
Topics: Acetaminophen; Aminophenols; Animals; Astrocytoma; Cell Line; Cyclooxygenase Inhibitors; In Vitro Techniques; Kidney Medulla; Male; Mice; Neoplasms, Experimental; Neuroblastoma; Phenacetin; Phenetidine; Rats; Rats, Inbred Strains | 1982 |
Prostaglandin synthetase-catalyzed activation of phenacetin metabolites to genotoxic products.
Topics: Acetaminophen; Aminophenols; Animals; Biotransformation; DNA; Glutathione; Humans; Phenacetin; Prostaglandin-Endoperoxide Synthases; Rabbits; Urinary Bladder Neoplasms | 1982 |
Epidemiologic study of abuse of analgesics containing phenacetin. Renal morbidity and mortality (1968-1979).
Topics: Acetaminophen; Adult; Analgesics; Bacteriuria; Creatinine; Female; Humans; Kidney Diseases; Longitudinal Studies; Male; Middle Aged; Phenacetin; Prospective Studies; Specific Gravity; Substance-Related Disorders; Switzerland; Urine | 1983 |
In vivo O-de-ethylation of phenacetin in 3-methylcholanthrene-pretreated rats: gut wall and liver first-pass metabolism.
Topics: Acetaminophen; Animals; Biological Availability; Intestinal Absorption; Intestinal Mucosa; Kinetics; Liver; Male; Methylcholanthrene; Phenacetin; Rats; Rats, Inbred Strains | 1983 |
The effect of intercellular distribution of drug-metabolizing enzymes on the kinetics of stable metabolite formation and elimination by liver: first-pass effects.
Topics: Acetaminophen; Animals; Humans; Kinetics; Liver; Liver Circulation; Pharmaceutical Preparations; Phenacetin | 1983 |
Formation of chemically reactive metabolites of phenacetin and acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Cricetinae; Cytochrome P-450 Enzyme System; Glucuronates; Glutathione; Kinetics; Liver; Microsomes, Liver; Phenacetin; Sulfurtransferases | 1981 |
Reduction of inflammatory brain edema by nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Benzoxazoles; Brain; Brain Edema; Copper; Dexamethasone; Female; Male; Phenacetin; Propionates; Rats; Rats, Inbred Lew | 1981 |
Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man.
Topics: Acetaminophen; Animals; Ascorbic Acid; Biotransformation; Cricetinae; Humans; Kidney; Kinetics; Liver; Male; Mice; Mutagenicity Tests; Mutagens; Paraoxon; Phenacetin; Rats; Salmonella typhimurium; Species Specificity | 1980 |
Analgesic nephropathy in 1981: which drug is responsible?
Topics: Acetaminophen; Analgesics; Humans; Kidney; Kidney Diseases; Nephritis, Interstitial; Phenacetin | 1982 |
Epidemiology of analgesic nephropathy in Belgium.
Topics: Acetaminophen; Analgesics; Antipyrine; Aspirin; Belgium; Caffeine; Drug Combinations; Humans; Kidney Diseases; Phenacetin | 1982 |
Metabolite kinetics: formation of acetaminophen from deuterated and nondeuterated phenacetin and acetanilide on acetaminophen sulfation kinetics in the perfused rat liver preparation.
Topics: Acetaminophen; Acetanilides; Animals; Biotransformation; Deuterium; In Vitro Techniques; Kinetics; Liver; Male; Phenacetin; Rats; Rats, Inbred Strains; Sulfates | 1982 |
Amphibian organ culture in experimental toxicology: the effects of paracetamol and phenacetin on cultured tissues from urodele and anuran amphibians.
Topics: Acetaminophen; Alkylation; Animals; Anura; Kidney; L-Lactate Dehydrogenase; Liver; Organ Culture Techniques; Phenacetin; Phenetidine; Toxicology; Urodela | 1982 |
[Toxicologico-chemical urine analysis following intake of phenacetin-(paracetamol) and aspirin-containing analgesics].
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Female; Humans; Male; Middle Aged; Phenacetin | 1982 |
Analgesic drugs in breast milk and plasma.
Topics: Acetaminophen; Adult; Analgesics; Caffeine; Codeine; Female; Humans; Kinetics; Milk, Human; Morphine; Phenacetin; Salicylates | 1981 |
[N,O-diacetyl-p-aminophenol formation by combined use of aspirin with phenacetin and acetaminophen in vivo (author's transl)].
Topics: Acetaminophen; Animals; Aspirin; Drug Combinations; Drug Interactions; Male; Phenacetin; Rabbits; Rats | 1980 |
Rotary press utilizing a flexible die wall.
Topics: Acetaminophen; Ascorbic Acid; Excipients; Phenacetin; Pressure; Tablets; Technology, Pharmaceutical | 1981 |
Functional zones in rat liver: the degree of overlap.
Topics: Acetaminophen; Animals; Kinetics; Liver; Liver Circulation; Liver Regeneration; Models, Biological; Phenacetin; Rats | 1981 |
Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen).
Topics: Acetaminophen; Adenocarcinoma; Analgesics; Animals; Antipyrine; Caffeine; Carcinogens; Carcinoma, Squamous Cell; Kidney; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experimental; Phenacetin; Rats; Rats, Inbred Strains; Sarcoma; Time Factors; Urinary Tract; Urologic Diseases | 1981 |
Functional zones in the liver.
Topics: Acetaminophen; Animals; Liver; Phenacetin; Rats | 1981 |
[What is the therapeutic value of so-called flu-drugs?].
Topics: Acetaminophen; Aspirin; Drug Combinations; Humans; Influenza, Human; Phenacetin; Quinine | 1981 |
Hydrolysis of aromatic amides as assay for carboxylesterases-amidases.
Topics: Acetaminophen; Acetanilides; Amidohydrolases; Aniline Compounds; Carboxylesterase; Carboxylic Ester Hydrolases; Hydrolysis; Methods; Phenacetin; Spectrometry, Fluorescence; Spectrophotometry | 1981 |
Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.
Topics: Acetaminophen; Animals; Female; Liver; Necrosis; Nephritis, Interstitial; Phenacetin; Rats; Rats, Gunn | 1981 |
Simultaneous quantitation of acetaminophen, aspirin, caffeine, codeine phosphate, phenacetin, and salicylamide by high-pressure liquid chromatography.
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Codeine; Phenacetin; Salicylamides | 1980 |
[25 years of phenacetin abuse].
Topics: Acetaminophen; Humans; Kidney Papillary Necrosis; Legislation, Drug; Nephritis, Interstitial; Phenacetin; Substance-Related Disorders; Switzerland | 1980 |
A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cricetinae; Hydroxamic Acids; Hydroxyacetylaminofluorene; Male; Mesocricetus; Microsomes, Liver; Phenacetin; Spectrophotometry; Structure-Activity Relationship | 1980 |
On the location of cellular functions in perfused organs.
Topics: Acetaminophen; Animals; Liver; Models, Biological; Perfusion; Phenacetin; Rats | 1980 |
[Phenacetin or paracetamol?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Humans; Kidney Papillary Necrosis; Legislation, Drug; Netherlands; Phenacetin | 1980 |
Drug metabolism in white vegetarians.
Topics: Acetaminophen; Adult; Analgesics; Antipyrine; Diet, Vegetarian; Female; Half-Life; Humans; Liver; Male; Phenacetin; Plant Proteins, Dietary; White People | 1980 |
Analgesic nephropathy induced by common proprietary mixtures.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Caffeine; Drug Combinations; Female; Humans; Kidney Papillary Necrosis; Nonprescription Drugs; Phenacetin; Rats; Salicylamides; Substance-Related Disorders | 1980 |
[H. U. Zollinger: 25 years of phenacetin abuse].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Legislation, Drug; Phenacetin; Phenetidine; Substance-Related Disorders; Switzerland | 1980 |
Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats.
Topics: Acetaminophen; Animals; Bile; Biotransformation; Kinetics; Liver; Perfusion; Phenacetin; Rats; Sulfates | 1981 |
Analgesics and cancers of the renal pelvis and ureter.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Case-Control Studies; Female; Humans; Kidney Neoplasms; Kidney Pelvis; Male; Middle Aged; Phenacetin; Ureteral Neoplasms | 1995 |
Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2.
Topics: Acetaminophen; Animals; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Kinetics; Liver; Oxidoreductases; Phenacetin; Transfection | 1995 |
Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N-propylnitrosamine and uracil.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Carcinogens; Cell Transformation, Neoplastic; Male; Mutagens; Nitrosamines; Phenacetin; Rats; Rats, Inbred F344; Uracil; Urinary Tract; Urologic Neoplasms | 1995 |
International renal-cell cancer study. II. Analgesics.
Topics: Acetaminophen; Age Factors; Carcinoma, Renal Cell; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Phenacetin; Pyrazoles; Risk; Salicylates | 1995 |
Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver.
Topics: Acetaminophen; Animals; Bile; In Vitro Techniques; Liver; Malaria; Male; Models, Biological; Perfusion; Phenacetin; Plasmodium berghei; Rats; Rats, Wistar | 1994 |
Nitrosamine formation via non-prescription drugs?
Topics: Acetaminophen; Adrenergic alpha-Antagonists; Humans; Imidazoles; Nitrates; Nitrites; Nitrosamines; Nonprescription Drugs; Phenacetin | 1994 |
Use of analgesics and risk of renal cell cancer.
Topics: Acetaminophen; Adult; Aged; Aspirin; Carcinoma, Renal Cell; Case-Control Studies; Drug Combinations; Female; Humans; Kidney Neoplasms; Logistic Models; Male; Middle Aged; Odds Ratio; Phenacetin; Population Surveillance; Risk Assessment | 1994 |
Role of the hepatic artery in the metabolism of phenacetin and acetaminophen: intravital microscopic and multiple-indicator dilution study in perfused rat liver.
Topics: Acetaminophen; Animals; Blood Flow Velocity; Erythrocytes; Hepatic Artery; Indicator Dilution Techniques; Liver; Liver Circulation; Male; Microcirculation; Microscopy, Fluorescence; Perfusion; Phenacetin; Portal Vein; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 1994 |
Omeprazole does not enhance the metabolism of phenacetin, a marker of CYP1A2 activity, in healthy volunteers.
Topics: Acetaminophen; Adult; Biomarkers; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; Humans; Male; Omeprazole; Oxidoreductases; Phenacetin | 1994 |
Different roles for phenacetin and paracetamol in cancer of the kidney and renal pelvis.
Topics: Acetaminophen; Adult; Aged; Aspirin; Carcinoma, Renal Cell; Case-Control Studies; Drug Combinations; Female; Humans; Kidney Neoplasms; Kidney Pelvis; Logistic Models; Male; Middle Aged; New South Wales; Phenacetin; Risk Factors | 1993 |
Australian study links certain analgesics to renal cancers.
Topics: Acetaminophen; Australia; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Phenacetin; Risk | 1993 |
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Disease Models, Animal; Endotoxins; Fever; Kinetics; Lipopolysaccharides; Malaria; Male; Microsomes, Liver; Oxidoreductases; Pharmaceutical Preparations; Phenacetin; Plasmodium berghei; Rats; Rats, Wistar | 1993 |
High mortality from urothelial carcinoma despite regular tumor screening in patients with analgesic nephropathy after renal transplantation.
Topics: Acetaminophen; Adult; Aged; Analgesics; Carcinoma, Renal Cell; Female; Humans; Kidney Failure, Chronic; Kidney Neoplasms; Kidney Transplantation; Male; Middle Aged; Phenacetin; Retrospective Studies; Risk Factors; Survival Rate | 1996 |
The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate.
Topics: Acetaminophen; Asian People; Biomarkers; China; Cytochrome P-450 CYP1A2; Female; Humans; Male; Phenacetin; Sex Factors; White People | 1996 |
[Nephrotoxicity of analgesic combination preparations].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Humans; Kidney Failure, Chronic; Phenacetin; Risk Factors | 1997 |
[Comment on the contribution: "Usefulness of fixed analgesic combinations exemplified by thomapyrin"].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Humans; Kidney Failure, Chronic; Phenacetin; Risk Factors | 1997 |
Long-term maintenance of drug-metabolizing enzyme activities in rat hepatocytes after cryopreservation.
Topics: Acetaminophen; Acetylation; Animals; Cell Survival; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Dimethyl Sulfoxide; Epithelial Cells; Glucuronates; Liver; Phenacetin; Rats; Rats, Sprague-Dawley | 1997 |
NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat.
Topics: Acetaminophen; Acetylation; Animals; Deuterium; Magnetic Resonance Spectroscopy; Male; Phenacetin; Rats; Rats, Sprague-Dawley | 1997 |
Monitoring in situ liver metabolism in rats using microdialysis. Comparison of microdialysis mass-transport model predictions to experimental metabolite generation data.
Topics: Acetaminophen; Animals; Glucuronates; Humans; Liver; Male; Microdialysis; Models, Chemical; Phenacetin; Rats; Rats, Sprague-Dawley | 1998 |
Spectrophotometric method for the determination of paracetamol and phenacetin.
Topics: Acetaminophen; Alkalies; Analgesics, Non-Narcotic; Drug Stability; Hydrolysis; Isoniazid; Naphthoquinones; Phenacetin; Spectrophotometry | 1998 |
Analgesic nephropathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Drug Interactions; Humans; Kidney Diseases; Phenacetin | 1998 |
Incidence of analgesic nephropathy in Berlin since 1983.
Topics: Acetaminophen; Age Factors; Aged; Analgesics; Berlin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glomerulonephritis; Humans; Kidney Failure, Chronic; Kidney Transplantation; Middle Aged; Phenacetin; Polycystic Kidney Diseases; Prevalence; Renal Replacement Therapy | 1999 |
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
Topics: Acetaminophen; Animals; Carcinogens; Carcinoma; Cytochrome P-450 CYP1A2; Female; Kidney Neoplasms; Male; Mice; Organ Size; Phenacetin; Survival Rate; Time Factors; Urinary Bladder | 1999 |
Regular use of analgesics is a risk factor for renal cell carcinoma.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Carcinoma, Renal Cell; Case-Control Studies; Dose-Response Relationship, Drug; Ethnicity; Female; Humans; Kidney Neoplasms; Los Angeles; Male; Middle Aged; Phenacetin; Risk Factors | 1999 |
Doubts about a particularly high nephrotoxicity of combination analgesics.
Topics: Acetaminophen; Analgesics; Drug Combinations; Humans; Kidney; Phenacetin | 1999 |
The behaviour of N-(phenylsulfonyl)-glycine and phenacetin in a municipal sewage treatment plant--a case study.
Topics: Acetaminophen; Alanine; Germany; Phenacetin; Sarcosine; Sewage; Sulfones; Urban Health; Water Pollutants, Chemical | 2000 |
Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Magnetic Resonance Spectroscopy; Phenacetin; Rats | 1999 |
Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dipyrone; Disinfectants; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Male; Pain; Phenacetin; Rats; Rats, Long-Evans; Reinforcement, Psychology | 2000 |
[Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary].
Topics: Acetaminophen; Adult; Aged; Amphetamine; Analgesics; Aspirin; Caffeine; Codeine; Female; Humans; Hungary; Kidney Failure, Chronic; Male; Middle Aged; Phenacetin; Prevalence; Renal Dialysis; Tomography, X-Ray Computed | 2001 |
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines | 2001 |
Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.
Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Humans; Microsomes, Liver; Oxazines; Phenacetin; Quinidine; Quinine; Rats; Recombinant Proteins; Yeasts | 2001 |
A comparison of some pharmacological effects of acetophenetidin and N-acetyl p-aminophenol.
Topics: Acetaminophen; Aminophenols; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Phenacetin; Phenols | 1953 |
[P-hydroxyacetanilide; comparison of the antipyretic and analgesic effects of this compound with those of antipyrine, phenacetin, pyramidon and quinine].
Topics: Acetaminophen; Acetanilides; Aminopyrine; Analgesics; Antipyretics; Antipyrine; Phenacetin; Quinine | 1953 |
[Experimental research on erythrocyte and organ changes induced by N-acetyl-p-aminophenol and phenacetin].
Topics: Acetaminophen; Acetanilides; Erythrocytes; Phenacetin | 1958 |
[The influence of age on the conversion of phenacetin, p-phenetidin, N-acetyl-p-aminophenol, p-aminophenol and aniline in the dog].
Topics: Acetaminophen; Acetanilides; Aging; Aminophenols; Aniline Compounds; Animals; Dogs; Humans; Phenacetin | 1960 |
Analgesic antipyretic drugs as antagonists of bradykinin.
Topics: Acetaminophen; Acetylcholine; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Aspirin; Atropine; Bradykinin; Guinea Pigs; Histamine; Ileum; Kallikreins; Lysergic Acid Diethylamide; Morphine; Phenacetin; Phthalic Acids; Rats; Serotonin | 1960 |
Observations on the effect of phenacetin and N-acetyl-p-aminophenol on rat kidneys.
Topics: Acetaminophen; Acetanilides; Animals; Kidney; Phenacetin; Rats | 1961 |
Induction of interstitial nephritis in rats fed phenacetin and NAPA (N-acetyl-p-aminophenol).
Topics: Acetaminophen; Animals; Nephritis; Nephritis, Interstitial; Phenacetin; Rats | 1962 |
On action of Napa (n-acetyl-p-aminophenol) on the induction of interstitial nephritis in rats.
Topics: Acetaminophen; Acetanilides; Animals; Nephritis, Interstitial; Phenacetin; Rats | 1962 |
On the effect of phenacetin and Napa (n-acetyl-p-aminophenol) on the development of bacterial interstitial nephritis in the rat.
Topics: Acetaminophen; Animals; Nephritis; Nephritis, Interstitial; Phenacetin; Rats | 1962 |
[Comparative studies on the toxicity of phenacetin and N-acetyl-p-aminophenol].
Topics: Acetaminophen; Acetanilides; Humans; Phenacetin | 1962 |
DEGENERATIVE JOINT DISEASES--DISCS AND OSTEOARTHRITIS. II. DIAGNOSIS AND MANAGEMENT OF OSTEOARTHRITIS.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Diagnosis, Differential; Humans; Osteoarthritis; Oxyphenbutazone; Phenacetin; Phenylbutazone; Physical Therapy Modalities; Salicylates | 1963 |
A BIOCHEMICAL DISTINCTION BETWEEN NON-STEROID ANTI-INFLAMMATORY AND ANALGESIC DRUGS.
Topics: Acetaminophen; Acetanilides; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Antipyrine; Cartilage; Inflammation; Liver; Metabolism; Oxyphenbutazone; Phenacetin; Phenylbutazone; Phosphates; Research; Salicylamides; Salicylic Acid | 1963 |
THE COMPARATIVE PHARMACOLOGY.
Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Blood Coagulation Disorders; Cardiovascular System; Endocrine Glands; Gastrointestinal Tract; Hypersensitivity; Kidney; Liver; Metabolism; Pharmacology; Phenacetin; Phenylbutazone; Respiration; Salicylamides; Substance-Related Disorders; Toxicology | 1963 |
SOME ANTIPYRETICS RELATED TO ASPIRIN AND PHENACETIN.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Anilides; Antipyretics; Aspirin; Chemistry, Pharmaceutical; Pharmacology; Pharmacy; Phenacetin; Research; Toxicology | 1963 |
[COMPARATIVE STUDY ON THE TOXICOLOGY OF PHENACETIN (ACETOPHENETIDIN) AND ACETO-AMINOPHENOL (N-ACETYL-P-AMINOPHENOL)].
Topics: Acetaminophen; Aminophenols; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Mice; Phenacetin; Rats; Research; Toxicology | 1963 |
THE RENAL CONCENTRATING CAPACITY IN ALBINO RATS AFTER LONG-TERM CONSUMPTION OF PHENACETIN, NAPA (N-ACETYL-P-AMINOPHENOL) AND ACETYLSALICYLIC ACID.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Body Weight; Erythrocyte Count; Hematuria; Leukocyte Count; Osmosis; Phenacetin; Pyuria; Rats; Research; Toxicology; Urine | 1964 |
CHRONIC TOXICITY STUDIES ON PHENACETIN, N-ACETYL-P-AMINOPHENOL (NAPA) AND ACETYLSALICYLIC ACID ON CATS.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Cats; Chemical and Drug Induced Liver Injury; Hepatitis; Methemoglobin; Phenacetin; Research; Toxicology | 1964 |
[QUALITATIVE PAPER CHROMATOGRAPHIC DEMONSTRATION OF N-ACETYL-P-AMINPHENOL IN THE PRESENCE OF OTHER ANALGESICS].
Topics: Acetaminophen; Acetanilides; Analgesics; Chemistry, Pharmaceutical; Chromatography; Phenacetin; Research | 1963 |
EFFECT OF ANALGESICS IN RABBITS ON ERYTHROCYTE SURVIVAL TIME.
Topics: Acetaminophen; Analgesics; Aspirin; Chromium Isotopes; Erythrocyte Aging; Erythrocytes; Pharmacology; Phenacetin; Placebos; Rabbits; Radiometry; Research | 1965 |
[A SIMPLE METHOD FOR THE QUANTITATIVE PHOTOMETRIC OR POLAROGRAPHIC DETERMINATION OF PARACETAMOL OR PHENACETIN].
Topics: Acetaminophen; Chemistry, Pharmaceutical; Pharmacy; Phenacetin; Photometry; Polarography; Research | 1965 |
EFFECTS OF ACETYLSALICYLIC ACID, PHENACETIN, PARACETAMOL, AND CAFFEINE ON RENAL TUBULAR EPITHELIUM.
Topics: Acetaminophen; Aspirin; Caffeine; Cell Biology; Coloring Agents; Epithelium; Erythrocytes; Humans; Kidney Tubules; Leukocytes; Phenacetin; Placebos; Staining and Labeling; Toxicology; Urine | 1965 |
[Hemiglobin formation in the blood of man after intake of Phenacetin and of N-acetyl-p-aminophenol].
Topics: Acetaminophen; Acetanilides; Biochemical Phenomena; Hemoglobins; Humans; Male; Phenacetin | 1962 |
Renal PGE2 production in the human and rat following phenacetin, acetaminophen and p-aminophenol.
Topics: Acetaminophen; Aminophenols; Animals; Dinoprostone; Humans; Immunoassay; Kidney Medulla; Male; Microsomes; Phenacetin; Rats; Rats, Sprague-Dawley | 2002 |
Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli.
Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cloning, Molecular; Culture Media; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Escherichia coli; Fermentation; Glycerol; Hydroxytestosterones; NADPH-Ferrihemoprotein Reductase; Oxygen; Pharmaceutical Preparations; Phenacetin; Recombinant Proteins; Temperature; Testosterone | 2005 |
Understanding drug disposition alterations induced by acute spinal cord injury: role of injury level and route of administration for agents submitted to extensive liver metabolism.
Topics: Acetaminophen; Administration, Oral; Animals; Denervation; Disease Models, Animal; Female; Hepatic Artery; Injections, Intravenous; Liver; Metabolic Clearance Rate; Phenacetin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Spinal Cord Injuries; Thoracic Vertebrae; Time Factors | 2006 |
Towards an understanding of the molecular mechanism of solvation of drug molecules: a thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by paracetamol, acetanilide, and phenacetin.
Topics: 1-Octanol; Acetaminophen; Acetanilides; Crystallization; Phenacetin; Solubility; Solvents; Thermodynamics; Water | 2006 |
[Effect of some non-steroidal antiinflammatory drugs and isomeric dihydroxy benzoic acids on the AAPH initiated degradation of crocin].
Topics: Acetaminophen; Amidines; Anti-Inflammatory Agents, Non-Steroidal; Carotenoids; Free Radical Scavengers; Phenacetin; Salicylates | 2006 |
In memoriam 'analgesic nephropathy' (circa 1972-2006).
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Approval; History, 20th Century; History, 21st Century; Humans; Kidney Failure, Chronic; Phenacetin; Terminology as Topic | 2007 |
In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.
Topics: Acetaminophen; Aristolochic Acids; Cadmium Chloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Copper; Humans; In Vitro Techniques; Kidney Diseases; Mitochondria; Phenacetin; Regression Analysis; Subcellular Fractions | 2007 |
Analgesic nephropathy.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Drug Combinations; Headache; Humans; Kidney Diseases; Male; Nonprescription Drugs; Phenacetin; Tomography, X-Ray Computed | 2007 |
Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice.
Topics: Acetaminophen; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Injections, Intraperitoneal; Male; Maze Learning; Memory; Methysergide; Mice; Phenacetin; Prostaglandin-Endoperoxide Synthases; Serotonin Antagonists | 2007 |
Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blood Pressure; Cyclooxygenase 2 Inhibitors; Dipyrone; Phenacetin; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2007 |
Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; Glutathione; Humans; Imines; Isoxazoles; Leflunomide; Mass Spectrometry; Mice; Microsomes, Liver; Phenacetin; Recombinant Proteins | 2008 |
The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cytochrome P-450 CYP1A2; Female; Humans; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Phenacetin | 2008 |
Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pharmaceutical Preparations; Phenacetin; Rats; Toxicity Tests | 2009 |
Efficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.
Topics: Acetaminophen; Animals; Antineoplastic Agents; Ascorbic Acid; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glutathione; Humans; Inhibitory Concentration 50; Kidney; Lipid Peroxidation; Liver; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; NAD; Oxidation-Reduction; Phenacetin; Reactive Oxygen Species; RNA Interference; Skin Neoplasms; Sulfhydryl Compounds; Time Factors | 2009 |
Significant increase in phenacetin oxidation on L382V substitution in human cytochrome P450 1A2.
Topics: Acetaminophen; Cytochrome P-450 CYP1A2; Humans; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Mutation; Oxidation-Reduction; Phenacetin; Substrate Specificity | 2010 |
Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen.
Topics: Acetaminophen; Animals; Base Sequence; Cell Line; DNA Primers; Humans; Hydrolases; Hydrolysis; Phenacetin; Spodoptera | 2010 |
Effect of dimethyl sulfoxide on in vitro cytochrome P4501A2 mediated phenacetin O-deethylation in human liver microsomes.
Topics: Acetaminophen; Acetonitriles; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dimethyl Sulfoxide; Humans; Methanol; Microsomes, Liver; Phenacetin; Solvents | 2011 |
Electrochemical oxidation by square-wave potential pulses in the imitation of phenacetin to acetaminophen biotransformation.
Topics: Acetaminophen; Biotransformation; Dealkylation; Drug Discovery; Electrochemical Techniques; Mass Spectrometry; Oxidation-Reduction; Pharmaceutical Preparations; Phenacetin | 2011 |
Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs.
Topics: Acetaminophen; Administration, Oral; Algorithms; Analgesics, Non-Narcotic; Animals; Biotransformation; Codon, Terminator; Cytochrome P-450 CYP1A2; Dogs; Dose-Response Relationship, Drug; Half-Life; Heterozygote; Homozygote; Infusions, Intravenous; Male; Metabolic Clearance Rate; Mutation; Phenacetin; Polymorphism, Single Nucleotide; Substrate Specificity | 2012 |
The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arylsulfotransferase; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochromes; Disease Models, Animal; Glucuronosyltransferase; Kidney Diseases; Male; Phenacetin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2012 |
Electron attachment to antipyretics: possible implications of their metabolic pathways.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Aspirin; Electrons; Humans; Ibuprofen; Ions; Metabolic Networks and Pathways; Models, Molecular; Phenacetin; Quantum Theory | 2012 |
Development of qualitative and quantitative analysis methods in pharmaceutical application with new selective signal excitation methods for 13 C solid-state nuclear magnetic resonance using 1 H T1rho relaxation time.
Topics: Acetaminophen; Antipyrine; beta-Cyclodextrins; Caffeine; Carbon Isotopes; Chemistry, Pharmaceutical; Crystallization; Drug Combinations; Excipients; Indomethacin; Lactose; Magnetic Resonance Spectroscopy; Nifedipine; Pharmaceutical Preparations; Phenacetin; Povidone; Protons; Pyridones; Signal Processing, Computer-Assisted; Technology, Pharmaceutical | 2013 |
Understanding the degradation of electrochemically-generated reactive drug metabolites by quantitative NMR.
Topics: Acetaminophen; Benzoquinones; Biotransformation; Electrolysis; Humans; Imines; Nuclear Magnetic Resonance, Biomolecular; Phenacetin; Solutions | 2013 |
Facile and novel electrochemical preparation of a graphene-transition metal oxide nanocomposite for ultrasensitive electrochemical sensing of acetaminophen and phenacetin.
Topics: Acetaminophen; Electrochemical Techniques; Electrodes; Graphite; Humans; Hydrogen-Ion Concentration; Nanocomposites; Phenacetin; Zinc Oxide | 2014 |
Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochromes; Disease Models, Animal; Half-Life; Inflammation; Male; Metabolic Clearance Rate; Models, Biological; Phenacetin; Rats, Wistar; Tissue Distribution; Turpentine | 2015 |
Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines.
Topics: Acetaminophen; Bioreactors; Caco-2 Cells; Coculture Techniques; Cytochrome P-450 CYP1A1; Hep G2 Cells; Humans; Intestinal Absorption; Liver; Microfluidics; Phenacetin | 2014 |
Predicting the excess solubility of acetanilide, acetaminophen, phenacetin, benzocaine, and caffeine in binary water/ethanol mixtures via molecular simulation.
Topics: Acetaminophen; Acetanilides; Benzocaine; Caffeine; Ethanol; Models, Molecular; Pharmaceutical Preparations; Phenacetin; Solubility; Solvents; Water | 2015 |
Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats.
Topics: Acetaminophen; Animals; Area Under Curve; Cytochrome P-450 CYP1A2; Cytochromes; Fruit; Herb-Drug Interactions; Liver; Male; Microsomes, Liver; Phenacetin; Plant Extracts; Rats, Sprague-Dawley; Ziziphus | 2015 |
Long-term culture and cryopreservation does not affect the stability and functionality of human embryonic stem cell-derived hepatocyte-like cells.
Topics: Acetaminophen; Bupropion; Cell Culture Techniques; Cell Differentiation; Cryopreservation; Diclofenac; Hepatocytes; Human Embryonic Stem Cells; Humans; Phenacetin | 2016 |
The Assessment of Liver Reserve Function by Spectrophotometry based on Determination of Phenacetin and Paracetamol.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Liver; Phenacetin; Spectrophotometry; Temperature | 2015 |
Enzyme-inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Area Under Curve; Berberine; Blotting, Western; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Enzyme Induction; Half-Life; Hep G2 Cells; Humans; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tandem Mass Spectrometry | 2017 |
Water-in-oil microcompartments for the study of biomimetic drug metabolism.
Topics: Acetaminophen; Biomimetic Materials; Chromatography, High Pressure Liquid; Diffusion; Emulsions; Kinetics; Metabolome; Microspheres; Models, Chemical; Oils; Phenacetin; Tandem Mass Spectrometry; Water | 2020 |
Simultaneous detection of phenacetin and paracetamol using ELISA and a gold nanoparticle-based immunochromatographic test strip.
Topics: Acetaminophen; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Gold; Limit of Detection; Metal Nanoparticles; Phenacetin | 2021 |
Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could Be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity.
Topics: Acetaminophen; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Phenacetin; Phospholipids | 2022 |
Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Metoprolol; Midazolam; Phenacetin; Rats; Tandem Mass Spectrometry; Tolbutamide | 2023 |