acetaminophen and pentoxifylline

acetaminophen has been researched along with pentoxifylline in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (15.79)	18.2507
2000's	11 (57.89)	29.6817
2010's	5 (26.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Benzick, AE; Hansen, TN; Montgomery, CA; Smith, CV; Welty, SE	1
Amend, WJ; Birnbaum, JL; Melzer, JS; Snyder, JP; Tomlanovich, SJ; Vasconcelos, M; Vincenti, FG	1
Chiwakata, CB; Dietrich, M; Egbring, R; Gaus, W; Hassemer, M; Hemmer, CJ; Hogel, J; Hort, G; Kern, P; Nawroth, PP; Seitz, R	1
Boobis, AR; Edwards, RJ; Murray, BP; Murray, S; Odupitan, AO	1
Chappell, AS; D'Souza, DN; Iyengar, S; Pritchett, YL; Raskin, J; Smith, TR; Wang, F; Wernicke, JF	1
Amabeoku, GJ; Erasmus, SJ; Mukinda, JT; Ojewole, JA	1
Guk, K; Kang, G; Kim, H; Kim, Y; Lee, D; Lim, H; Yoo, D	1

Reviews

1 review(s) available for acetaminophen and pentoxifylline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for acetaminophen and pentoxifylline

Article	Year
Pentoxifylline reduces the first-dose reactions following OKT3. Transplantation proceedings, 1993, Volume: 25, Issue:2 Suppl 1 Topics: Acetaminophen; Antigens, CD; Biopsy; CD3 Complex; Diphenhydramine; Graft Rejection; Humans; Kidney Transplantation; Muromonab-CD3; Pentoxifylline; Prednisolone; T-Lymphocyte Subsets; Tumor Necrosis Factor-alpha	1993
Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:4 Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antimalarials; Biopterins; Drug Therapy, Combination; Female; Humans; L-Lactate Dehydrogenase; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Neopterin; Parasitemia; Pentoxifylline; Phenanthrenes; Phosphodiesterase Inhibitors; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Tumor Necrosis Factor-alpha	1997
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain. Pain medicine (Malden, Mass.), 2007, Volume: 8, Issue:6 Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathies; Diclofenac; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Lipids; Male; Meloxicam; Middle Aged; Neuralgia; Pentoxifylline; Selective Serotonin Reuptake Inhibitors; Thiamine; Thiazines; Thiazoles; Thioctic Acid; Thiophenes; Time; Vitamin B 12	2007

Other Studies

15 other study(ies) available for acetaminophen and pentoxifylline

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogPoct: a tool for lipophilicity determination in drug discovery. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Investigation of possible mechanisms of hepatic swelling and necrosis caused by acetaminophen in mice. Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Animals; Cell Adhesion Molecules; Intercellular Adhesion Molecule-1; Liver; Male; Mice; Mice, Inbred ICR; Necrosis; Organ Size; Pentoxifylline; RNA, Messenger	1993
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:3 Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines	2001
Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice. Methods and findings in experimental and clinical pharmacology, 2009, Volume: 31, Issue:10 Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fever; Lethal Dose 50; Male; Mentha; Mice; Morphine; Pain; Pain Measurement; Pentoxifylline; Plant Extracts; Plant Leaves; Rats; Toxicity Tests, Acute	2009
Fully biodegradable and cationic poly(amino oxalate) particles for the treatment of acetaminophen-induced acute liver failure. International journal of pharmaceutics, 2012, Sep-15, Volume: 434, Issue:1-2 Topics: Acetaminophen; Acute Disease; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytosol; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Inflammation; Liver; Macrophages; Mice; Mice, Inbred BALB C; Mononuclear Phagocyte System; Oxalates; Pentoxifylline; Tissue Distribution	2012