Compounds > acetaminophen

acetaminophen and nadp

acetaminophen has been researched along with nadp in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199024 (55.81)18.7374
1990's7 (16.28)18.2507
2000's5 (11.63)29.6817
2010's5 (11.63)24.3611
2020's2 (4.65)2.80

Authors

AuthorsStudies
Hinson, JA; Mitchell, JR; Nelson, SD1
Glaumann, H; Moldéus, P; Rane, A; Rollins, DE; von Bahr, C1
Alvarez, A; Chávez, M; Chávez-Anaya, E; Medina, C; Medina, MD; Mendoza, R; Ramírez, MG; Sáenz, G; Vaca, G; Vargas, M1
Kamiyama, T; Liu, J; Marumo, F; Miyakawa, H; Sato, C; Shigesawa, T; Tajiri, K1
Marumo, F; Sato, C1
Hinson, JA; Potter, DW3
Delaforge, M; Jaouen, M; Jollès, P; Mansuy, D; Migliore-Samour, D1
Bosman, P; de Vries, J; van de Straat, R; Vermeulen, NP; Vromans, RM1
Nelson, SD; Slattery, JT; Thummel, KE1
Cannon, M; Leeder, JS; Nakhooda, A; Spielberg, SP1
Benson, RW; Hinson, JA; Potter, DW; Pumford, NR; Roberts, DW1
Araya, H; Awazu, S; Hayashi, M; Horie, T1
Berlin, T; Larsson, R; Moldéus, P; Olsson, LI; Ross, D1
Albano, E; Harvison, PJ; Moldéus, P; Nelson, SD; Rundgren, M1
Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ1
Kampffmeyer, HG1
Staudinger, H; von Kerékartó, B1
Büch, H; Hey, D; Rummel, W; Staudinger, H; Ullrich, V1
Schnitger, F; Uehleke, H1
Chatfield, DH; Morton, DM1
Dahlin, DC; Lu, AY; Miwa, GT; Nelson, SD1
Boroujerdi, M; Carlo, JR; Rosenbaum, SE1
Baillie, TA; Dahlin, DC; Nelson, SD; Streeter, AJ1
Duggin, GG; Horvath, JS; Mohandas, J; Tiller, DJ1
Corcoran, GB; Horning, EC; Mitchell, JR; Vaishnav, YN1
Hamrick, ME; Harris, SR1
Erickson, RR; Holtzman, JL; Zhou, L1
Baede, EJ; Bessems, JG; de Groot, MJ; te Koppele, JM; Vermeulen, NP1
Curti, C; Mingatto, FE; Pigoso, AA; Rodrigues, T; Santos, AC; Uyemura, SA1
Bazzi, MD; Duhaiman, AS; Rabbani, N1
Johnson, BM; van Breemen, RB1
Devaki, T; Raghavendran, HB; Sathivel, A1
Ikeda, T1
Macneil, DJ; Menetski, J; Mumick, S; Nizner, P; Qian, S; Reitman, ML; Tota, MR1
Dansette, PM; Defoy, D; Klarskov, K; Neugebauer, W; Wagner, JR1
Aracena, P; Letelier, ME; López-Valladares, M; Peredo-Silva, L; Rojas-Sepúlveda, D1
Chapman, JD; Goodlett, DR; Harrelson, JP; Nelson, SD; Stamper, BD1
Jin, T; Liu, J; Shi, JS; Tao, N; Wu, Q; Zhang, D; Zhu, QN1
Behrends, V; Bravo-Santano, N; Giskeødegård, GF; Keun, HC; Letek, M1
Cai, N; Cheng, K; Liang, H; Wen, J; Xiong, Y; Zhang, W; Zhang, Y; Zhu, J1
An, YJ; de Guzman, ACV; Lee, S; Nguyen, TTM; Phan, HD; Seo, M1

Reviews

2 review(s) available for acetaminophen and nadp

ArticleYear
[Drug-induced liver injury].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2006, Volume: 127, Issue:6

    Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP2E1; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Genetic Predisposition to Disease; Humans; Hypoglycemic Agents; Imines; NADP; Pharmacogenetics; Thiazolidinediones; Troglitazone

2006
The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Acetaminophen; Antineoplastic Agents; Antioxidants; Apoptosis; Artemisinins; Auranofin; Cell Death; Cisplatin; Epigenesis, Genetic; Fatty Acids; Ferroptosis; Haloperidol; Humans; Indoles; Iron; Lapatinib; Mevalonic Acid; NADP; Neoplasms; Oxidation-Reduction; Oxidative Stress; Oxygen; Quinolines; Reactive Oxygen Species; Sorafenib; Spiro Compounds; Sulfasalazine; Trigonella

2020

Trials

1 trial(s) available for acetaminophen and nadp

ArticleYear
In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh).
    Chemical research in toxicology, 2003, Volume: 16, Issue:7

    Topics: Acetaminophen; Acetylcysteine; Adult; Biotransformation; Catechols; Cimicifuga; Dietary Supplements; Dose-Response Relationship, Drug; Female; Glutathione; Humans; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Middle Aged; NADP; Plant Extracts; Quinones

2003

Other Studies

40 other study(ies) available for acetaminophen and nadp

ArticleYear
Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin.
    Molecular pharmacology, 1977, Volume: 13, Issue:4

    Topics: Acetaminophen; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Isotopes; Phenacetin; Phenobarbital

1977
Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells.
    Science (New York, N.Y.), 1979, Sep-28, Volume: 205, Issue:4413

    Topics: Acetaminophen; Biotransformation; Cytochrome P-450 Enzyme System; Female; Glutathione; Humans; Liver; Maternal-Fetal Exchange; Microsomes, Liver; NADP; Pregnancy

1979
Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies.
    Archives of medical research, 1992,Spring, Volume: 23, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aldehyde Reductase; Animals; Black People; Cataract; Child; Chloramphenicol; Costa Rica; Dehydroepiandrosterone; Diabetes Complications; Diabetes Mellitus; Disease Models, Animal; Erythrocytes; Galactosemias; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Incidence; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Male; Middle Aged; NADP; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sorbitol

1992
Effects of caffeine on paracetamol activation in rat and mouse liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:4

    Topics: Acetaminophen; Animals; Caffeine; Inactivation, Metabolic; Male; Mice; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains

1992
Synergistic effect of NADH on NADPH-dependent acetaminophen activation in liver microsomes and its inhibition by cyanide.
    Life sciences, 1991, Volume: 48, Issue:25

    Topics: Acetaminophen; Animals; Kinetics; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; NAD; NADP; Rats; Rats, Inbred Strains; Sodium Cyanide

1991
Acetaminophen peroxidation reactions.
    Drug metabolism reviews, 1989, Volume: 20, Issue:2-4

    Topics: Acetaminophen; Animals; Ascorbic Acid; Benzene Derivatives; Cytochrome P-450 Enzyme System; Horseradish Peroxidase; In Vitro Techniques; Microsomes, Liver; NADP; Oxidation-Reduction; Peroxides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains

1989
In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity.
    Experientia, 1989, Sep-15, Volume: 45, Issue:9

    Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Lipid Peroxidation; Liver Diseases; Mice; Microsomes, Liver; NADP; Oligopeptides; Pimelic Acids

1989
Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol.
    Chemico-biological interactions, 1988, Volume: 64, Issue:3

    Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Electron Transport; Free Radicals; Glutathione; Glutathione Disulfide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Pyridines; Rats; Rats, Inbred Strains

1988
Mechanism by which ethanol diminishes the hepatotoxicity of acetaminophen.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: Acetaminophen; Animals; Drug Interactions; Ethanol; Glutathione; Liver; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Time Factors

1988
Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3

    Topics: Acetaminophen; Animals; Cell Survival; Cytochrome P-450 Enzyme System; Glutathione; Glutathione Transferase; Humans; Lymphocytes; Male; NADP; Pyridines; Rats; Tetrazolium Salts; Thiazoles

1988
A sensitive immunochemical assay for acetaminophen-protein adducts.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Acetaminophen; Animals; Cysteine; Enzyme-Linked Immunosorbent Assay; Liver; Mathematics; Methods; Mice; Microsomes, Liver; NADP; Protein Binding; Proteins; Rabbits

1987
Alteration in rat liver microsomal membranes induced by acetaminophen.
    Journal of pharmacobio-dynamics, 1987, Volume: 10, Issue:7

    Topics: Acetaminophen; Acetylcysteine; Animals; Cytochrome P-450 Enzyme System; Fluorescence Polarization; Male; Membranes; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains

1987
Reactions of N-acetyl-p-benzoquinone imine with reduced glutathione, acetaminophen, and NADPH.
    Molecular pharmacology, 1986, Volume: 30, Issue:1

    Topics: Acetaminophen; Benzoquinones; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Liquid; Glutathione; Imines; NADP; Polymers

1986
Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450.
    The Journal of biological chemistry, 1987, Jan-25, Volume: 262, Issue:3

    Topics: Acetaminophen; Animals; Benzene Derivatives; Benzoquinones; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Glutathione; Horseradish Peroxidase; Imines; Kinetics; Macromolecular Substances; Microsomes, Liver; NADP; Oxidation-Reduction; Peroxidases; Rats; Rats, Inbred Strains

1987
Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Acetaminophen; Aminophenols; Animals; Arachidonic Acid; Arachidonic Acids; Glutathione; Glutathione Disulfide; Humans; Indomethacin; Kidney; Kinetics; Linolenic Acids; Lipid Peroxides; Male; Metyrapone; Microsomes; Models, Chemical; NADP; Phenetidine; Proadifen; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rabbits

1985
Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.
    Molecular pharmacology, 1985, Volume: 28, Issue:3

    Topics: Acetaminophen; Animals; Benzoquinones; Cell Survival; Dithiothreitol; Glutathione; Imines; In Vitro Techniques; Liver; Male; NADP; Rats; Rats, Inbred Strains

1985
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium

1973
Metabolic rate of phenacetin and of paracetamol in dogs before and after treatment with phenobarbital or skf 525 A.
    Biochemical pharmacology, 1974, Feb-01, Volume: 23, Issue:3

    Topics: Acetaminophen; Animals; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dealkylation; Dialysis; Dogs; Half-Life; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Phenacetin; Phenazines; Phenobarbital; Proadifen; Proteins

1974
[Oxygen dependency of the hydroxylation of acetanalid to 4-acetamino-phenol by rabbit liver microsomes].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1966, Volume: 347, Issue:1

    Topics: Acetaminophen; Acetanilides; Animals; Female; Liver; Male; Microsomes; NADP; Oxygen; Partial Pressure; Rabbits

1966
[Studies on the mechanism of hydroxylation and oxidative O-dealkylation of phenacetin in model systems].
    Biochemical pharmacology, 1967, Volume: 16, Issue:12

    Topics: Acetaminophen; Edetic Acid; Free Radicals; Hydroxides; Iron; Microsomes; Mixed Function Oxygenases; Models, Chemical; NAD; NADP; Phenacetin

1967
[Metabolism of phenacetin and p-phenetidine in the kidney].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1969, Volume: 264, Issue:3

    Topics: Acetaminophen; Aniline Compounds; Animals; Kidney; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenacetin; Rabbits

1969
The effects of adjuvant-induced arthritis on the liver metabolism of drugs in rats.
    Biochemical pharmacology, 1970, Volume: 19, Issue:2

    Topics: Acetaminophen; Adjuvants, Immunologic; Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis; Biological Transport, Active; Blood Proteins; Cholesterol; Cytochromes; Electrons; Glucose-6-Phosphatase; Glucuronates; Histocytochemistry; In Vitro Techniques; Liver Glycogen; Lymph Nodes; Male; Microsomes, Liver; Mycobacterium tuberculosis; NADP; Oxidoreductases; Phenobarbital; Rats; RNA; Serum Albumin; Succinate Dehydrogenase

1970
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:5

    Topics: Acetaminophen; Animals; Benzoquinones; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Imines; Kinetics; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction

1984
Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 46, Issue:3

    Topics: Acetaminophen; Animals; Anisoles; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Liver Diseases; Male; Mice; Mice, Inbred A; Microsomes, Liver; NADP; Necrosis; Protein Binding

1984
The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro.
    Chemico-biological interactions, 1984, Volume: 48, Issue:3

    Topics: Acetaminophen; Amino Acids; Animals; Benzoquinones; Caseins; Cysteine; Glutathione; Imines; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; NADP; Phenobarbital; Proteins; Serum Albumin, Bovine

1984
Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney.
    Toxicology and applied pharmacology, 1981, Volume: 61, Issue:2

    Topics: Acetaminophen; Animals; Arachidonic Acid; Arachidonic Acids; Cytochrome P-450 Enzyme System; Kidney; Male; Microsomes; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxidoreductases; Prostaglandin-Endoperoxide Synthases; Rabbits; Substrate Specificity

1981
Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.
    Molecular pharmacology, 1980, Volume: 18, Issue:3

    Topics: Acetaminophen; Animals; Ascorbic Acid; Benzoquinones; Cysteine; Imines; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Rats

1980
Antagonism of acetaminophen hepatotoxicity by phospholipase A2 inhibitors.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 79, Issue:1

    Topics: Acetaminophen; Animals; Calcium; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diltiazem; DNA; Homeostasis; Male; Mice; Mitochondria, Liver; NADP; Oxidation-Reduction; Phospholipases A; Phospholipases A2

1993
Studies comparing the kinetics of cysteine conjugation and protein binding of acetaminophen by hepatic microsomes from male mice.
    Biochimica et biophysica acta, 1997, Apr-17, Volume: 1335, Issue:1-2

    Topics: Acetaminophen; Animals; Cysteine; Cytochrome P-450 CYP2E1; Ethanol; Male; Mice; Microsomes, Liver; NAD; NADP; Protein Binding

1997
Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450.
    Xenobiotica; the fate of foreign compounds in biological systems, 1998, Volume: 28, Issue:9

    Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Free Radicals; Horseradish Peroxidase; Hydrogen; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Wistar; Thermodynamics

1998
Influence of nonsteroidal anti-inflammatory drugs on calcium efflux in isolated rat renal cortex mitochondria and aspects of the mechanisms involved.
    The international journal of biochemistry & cell biology, 1998, Volume: 30, Issue:9

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclosporine; Diclofenac; Dipyrone; Ibuprofen; In Vitro Techniques; Ion Transport; Kidney Cortex; Male; Mefenamic Acid; Mitochondria; NAD; NADP; Oxidation-Reduction; Piroxicam; Rats; Rats, Wistar; Salicylic Acid

1998
Inhibition of camel lens zeta-crystallin by aspirin and aspirin-like analgesics.
    The international journal of biochemistry & cell biology, 2002, Volume: 34, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Binding Sites; Binding, Competitive; Camelus; Crystallins; Ibuprofen; In Vitro Techniques; Kinetics; Lysine; NADP; Phenanthrenes; Pyridoxal Phosphate

2002
Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.
    World journal of gastroenterology, 2006, Jun-28, Volume: 12, Issue:24

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Endoplasmic Reticulum; Imines; Inactivation, Metabolic; Liver; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron; Microsomes, Liver; Mitochondria; NADP; NADPH-Ferrihemoprotein Reductase; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Sargassum; Tumor Necrosis Factor-alpha

2006
Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 103, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cytosol; Genotype; Glutathione; Liver; Malate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NADP

2008
Evaluation of deuterium labeled and unlabeled bis-methyl glutathione combined with nanoliquid chromatography-mass spectrometry to screen and characterize reactive drug metabolites.
    Chemical research in toxicology, 2011, Mar-21, Volume: 24, Issue:3

    Topics: Acetaminophen; Animals; Carbamazepine; Chromatography, High Pressure Liquid; Deuterium; Deuterium Exchange Measurement; Esterification; Glutathione; Isotope Labeling; Male; Microsomes; NADP; Nanotechnology; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization

2011
Microsomal oxidative damage promoted by acetaminophen metabolism.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Catechin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Glutathione Transferase; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Naphthoquinones; Oxidative Stress; Proadifen; Rats; Rats, Sprague-Dawley

2011
Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:8

    Topics: Acetaminophen; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1 Inhibitors; Humans; Isomerism; NADP; Spectrometry, Mass, Electrospray Ionization

2012
Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs.
    The American journal of Chinese medicine, 2014, Volume: 42, Issue:1

    Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Liver; Male; Metallothionein; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; NAD(P)H Dehydrogenase (Quinone); NADP; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Piper; Plant Extracts

2014
Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism.
    Archives of toxicology, 2019, Volume: 93, Issue:2

    Topics: Acetaminophen; Cell Survival; Citric Acid Cycle; Drug Synergism; Glutathione; Glycolysis; Hep G2 Cells; Humans; Lactates; Metabolism; Monocarboxylic Acid Transporters; NADP; Pyrimidinones; Symporters; Thiophenes; Toxicity Tests

2019
The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans.
    Metabolomics : Official journal of the Metabolomic Society, 2023, Jun-08, Volume: 19, Issue:6

    Topics: Acetaminophen; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatography, Liquid; DNA-Binding Proteins; Glutathione; Longevity; Mammals; Metabolomics; NADP; NF-E2-Related Factor 2; Tandem Mass Spectrometry

2023