Compounds > acetaminophen

acetaminophen and metyrapone

acetaminophen has been researched along with metyrapone in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19905 (45.45)18.7374
1990's2 (18.18)18.2507
2000's1 (9.09)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Goldstein, M; Nelson, EB1
Plewa, MJ; Verdier, MM; Wagner, ED1
Galinsky, RE; Nelson, EB; Rollins, DE1
Berlin, T; Larsson, R; Moldéus, P; Olsson, LI; Ross, D1
Fischer, LJ; Harman, AW1
Goldstein, M; Montes, M; Nelson, EB1
Plewa, MJ1

Reviews

1 review(s) available for acetaminophen and metyrapone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

10 other study(ies) available for acetaminophen and metyrapone

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Metyrapone as a treatment for acetaminophen (paracetamol) toxicity in mice.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 23, Issue:1

    Topics: Acetaminophen; Animals; Male; Metyrapone; Mice; Mice, Inbred ICR

1979
The biochemical mechanisms of the plant activation of promutagenic aromatic amines.
    Environmental and molecular mutagenesis, 1990, Volume: 15, Issue:4

    Topics: Acetaminophen; Benzoflavones; Biotransformation; Catechin; Cell Line; Ditiocarb; Fluorenes; Methimazole; Metyrapone; Mutagens; Mutation; Nicotiana; Oxidoreductases; Oxygenases; Phenylenediamines; Plants, Toxic; Potassium Cyanide

1990
Pharmacokinetic consequences and toxicologic implications of metyrapone-induced alterations of acetaminophen elimination in man.
    European journal of clinical pharmacology, 1987, Volume: 33, Issue:4

    Topics: Acetaminophen; Adult; Drug Interactions; Half-Life; Humans; Male; Metyrapone; Saliva

1987
Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Acetaminophen; Aminophenols; Animals; Arachidonic Acid; Arachidonic Acids; Glutathione; Glutathione Disulfide; Humans; Indomethacin; Kidney; Kinetics; Linolenic Acids; Lipid Peroxides; Male; Metyrapone; Microsomes; Models, Chemical; NADP; Phenetidine; Proadifen; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rabbits

1985
Hamster hepatocytes in culture as a model for acetaminophen toxicity studies with inhibitors of drug metabolism.
    Toxicology and applied pharmacology, 1983, Volume: 71, Issue:3

    Topics: Acetaminophen; Animals; Cells, Cultured; Cricetinae; Cytochrome P-450 Enzyme System; Ditiocarb; Dose-Response Relationship, Drug; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Mesocricetus; Metyrapone; Oxidation-Reduction; Piperonyl Butoxide

1983
Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice.
    Toxicology, 1980, Volume: 17, Issue:1

    Topics: Acetaminophen; Animals; Female; Glutathione; Lethal Dose 50; Liver; Metyrapone; Mice; Necrosis; Time Factors

1980
Blocking the plant activation of promutagenic aromatic amines by peroxidase inhibitors.
    Basic life sciences, 1993, Volume: 61

    Topics: Acetaminophen; Antimutagenic Agents; Benzoflavones; Catechin; Cells, Cultured; Ditiocarb; Methimazole; Metyrapone; Mutagenicity Tests; Mutagens; Peroxidases; Plants; Potassium Cyanide; Prodrugs; Salmonella typhimurium

1993