acetaminophen has been researched along with methotrexate in 48 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (10.42) | 18.7374 |
1990's | 7 (14.58) | 18.2507 |
2000's | 14 (29.17) | 29.6817 |
2010's | 20 (41.67) | 24.3611 |
2020's | 2 (4.17) | 2.80 |
Authors | Studies |
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Topliss, JG; Yoshida, F | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Rosenoer, VM; Tornay, AS | 1 |
Baptiste, P; Chang, DM; Schur, PH | 1 |
Hennigar, GR | 1 |
Klotz, U | 1 |
Mørland, J; Vonen, B | 1 |
Hayes, AH | 1 |
Jørgensen, G | 1 |
Creinin, MD | 1 |
Allen, RL; Billington, D; Osypiw, JC | 1 |
Cargill, I; Howell, S; Lindenthal, J; Sinclair, JF; Sinclair, PR; Taylor, T | 1 |
Diedrich, M; Fliedner, A; Henschel, KP; Wenzel, A | 1 |
Bache, K; Hauschild, A; Kröger, H; Krüger, D; Ohde, M; Thefeldt, W; Voigt, WP | 1 |
Varela-Moreiras, G | 1 |
Damato, R; Di Poi, E; Favret, G; Ferraccioli, GF; Gremese, E; Tomietto, P | 1 |
Bessis, D; Guilhou, JJ; Guillot, B; Legouffe, E | 1 |
Kumari, R; Uppal, SS | 1 |
Hersh, EV; Moore, PA; Pinto, A | 1 |
Förger, F; Østensen, M | 1 |
Colebatch, AN; Edwards, CJ; Marks, JL | 1 |
Chung, BC; Jung, BH; Kumar, BS; Kwon, OS | 1 |
Colebatch, AN; Edwards, CJ; Marks, JL; van der Heijde, DM | 1 |
Pais, R; Ratziu, V; Rusu, E | 1 |
Kirkendall, ES; Kouril, M; Minich, T; Spooner, SA | 1 |
Berber, M; Dincaslan, H; Incesoy Ozdemir, S; Tacyildiz, N; Unal, E; Yavuz, G | 1 |
Barreto, GE; Beiraghdar, F; Motaharinia, J; Panahi, Y; Sahebkar, A | 1 |
Alanazi, FK; Alshehri, S; Kazi, M; Masum, AA; Shariare, MH; Uddin, J | 1 |
Gaiser, C; Krähenbühl, S; Messner, CJ; Özkul, D; Schmidt, S; Suter-Dick, L; Terracciano, L | 1 |
9 review(s) available for acetaminophen and methotrexate
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Interactions of analgesics with other drugs.
Topics: Acetaminophen; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Blood Proteins; Drug Interactions; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Intestinal Absorption; Methotrexate; Protein Binding; Salicylates; Sulfonylurea Compounds; Uricosuric Agents; Urine | 1983 |
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
Adverse drug interactions involving common prescription and over-the-counter analgesic agents.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Interactions; Ethanol; Health Status; Humans; Lithium Compounds; Methotrexate; Nonprescription Drugs; Selective Serotonin Reuptake Inhibitors; Warfarin | 2007 |
Management of RA medications in pregnant patients.
Topics: Abatacept; Acetaminophen; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Contraindications; Cyclosporine; Female; Gestational Age; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Rituximab; Sulfasalazine; Young Adult | 2009 |
Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis).
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Aspirin; Drug Interactions; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Spondylarthritis; Spondylitis, Ankylosing | 2011 |
Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis; Aspirin; Contraindications; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Evidence-Based Medicine; Expert Testimony; Humans; International Cooperation; Methotrexate; Pain; Pain Management; Randomized Controlled Trials as Topic | 2012 |
The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease.
Topics: Acetaminophen; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Insulin Resistance; Male; Metabolic Syndrome; Methotrexate; Non-alcoholic Fatty Liver Disease; Obesity; Prevalence; Risk Factors; Trans-Activators; Viral Regulatory and Accessory Proteins | 2014 |
Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies.
Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Curcuma; Curcumin; Drug Administration Schedule; Humans; Kidney; Kidney Function Tests; Methotrexate; Rats | 2019 |
2 trial(s) available for acetaminophen and methotrexate
Article | Year |
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Methotrexate and misoprostol for abortion at 57-63 days gestation.
Topics: Abortion, Induced; Acetaminophen; Administration, Oral; Adult; Chorionic Gonadotropin; Codeine; Colic; Drug Therapy, Combination; Female; Humans; Ibuprofen; Injections, Intramuscular; Methotrexate; Mifepristone; Misoprostol; Pilot Projects; Pregnancy; Pregnancy Trimester, First; Time Factors | 1994 |
Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease-Free Survival; Drug Therapy, Combination; Female; HLA-DR1 Antigen; Humans; Male; Methotrexate; Middle Aged; Pain; Sulfasalazine | 2002 |
37 other study(ies) available for acetaminophen and methotrexate
Article | Year |
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QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptives, Oral; Drug Hypersensitivity; Female; Halothane; Humans; Isoniazid; Liver; Liver Neoplasms; Methotrexate; Pharmaceutical Preparations; Tetracycline | 1979 |
The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.
Topics: Acetaminophen; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Auranofin; Cell Division; Colchicine; Humans; Interleukin-1; Methotrexate; Monocytes; Penicillamine; Thymus Gland; Zymosan | 1990 |
Iatrogenic drug toxicity.
Topics: Acetaminophen; Age Factors; Amphotericin B; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Hemolysis; Humans; Isoniazid; Kidney Diseases; Methotrexate; Pharmaceutical Preparations; Probability; Time Factors | 1985 |
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Ethanol; Fentanyl; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Methotrexate; Oxytetracycline; Protein Biosynthesis; Rats; Valine | 1984 |
Therapeutic implications of drug interactions with acetaminophen and aspirin.
Topics: Acetaminophen; Antacids; Anticoagulants; Aspirin; Drug Interactions; Humans; Methotrexate; Propantheline; Sulfinpyrazone | 1981 |
[Effects of drugs on the liver. A review illustrated with 3 clinical cases].
Topics: Acetaminophen; Adult; Aged; Androgens; Chemical and Drug Induced Liver Injury; Denmark; Disulfiram; Drug-Related Side Effects and Adverse Reactions; Female; Halothane; Humans; Male; Methotrexate; Middle Aged; Sulfamethizole | 1994 |
Subpopulations of rat hepatocytes separated by Percoll density-gradient centrifugation show characteristics consistent with different acinar locations.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Cell Separation; Cell Survival; Cells, Cultured; Centrifugation, Density Gradient; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Male; Methotrexate; Pyruvate Kinase; Rats; Rats, Wistar | 1994 |
Toxicity of paracetamol in cultured chick hepatocytes treated with methotrexate.
Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfoximine; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Glutathione; Liver; Methionine Sulfoximine; Methotrexate | 1993 |
Environmental hazard assessment of pharmaceuticals.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Anticholesteremic Agents; Bacteria; Clofibric Acid; Daphnia; Ecosystem; Environmental Pollutants; Eukaryota; Fishes; Methotrexate; Risk Assessment; Salicylates; Salicylic Acid | 1997 |
Nicotinamide and methionine reduce the liver toxic effect of methotrexate.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Liver Diseases; Male; Methionine; Methotrexate; Mice; Mice, Inbred DBA; Niacinamide | 1999 |
Gemcitabine-associated scleroderma-like changes of the lower extremities.
Topics: Acetaminophen; Amitriptyline; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Carcinoma, Transitional Cell; Cisplatin; Clonazepam; Deoxycytidine; Dermis; Doxorubicin; Edema; Gemcitabine; Humans; Infusions, Intravenous; Leg; Lung Neoplasms; Male; Methotrexate; Middle Aged; Morphine; Scleroderma, Diffuse; Vinblastine | 2004 |
Prolonged remission in adult-onset Still's disease with etanercept.
Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Antirheumatic Agents; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Male; Methotrexate; Methylprednisolone; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Remission Induction; Still's Disease, Adult-Onset; Tramadol | 2006 |
Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Discriminant Analysis; Liver; Male; Mass Spectrometry; Metabolome; Metabolomics; Methotrexate; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Steroids | 2012 |
Analysis of electronic medication orders with large overdoses: opportunities for mitigating dosing errors.
Topics: Acetaminophen; Databases as Topic; Drug Overdose; Humans; Infusions, Parenteral; Medical Order Entry Systems; Medication Errors; Medication Systems, Hospital; Methotrexate | 2014 |
The Efficiency and Toxicity of Mifamurtide in Childhood Osteosarcoma.
Topics: Acetaminophen; Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma; Phosphatidylethanolamines; Retrospective Studies; Survival Rate; Turkey | 2018 |
Preparation and Optimization of PEGylated Nano Graphene Oxide-Based Delivery System for Drugs with Different Molecular Structures Using Design of Experiment (DoE).
Topics: Acetaminophen; Calorimetry, Differential Scanning; Diclofenac; Drug Carriers; Drug Delivery Systems; Graphite; Methotrexate; Microscopy, Electron, Scanning; Molecular Structure; Nanoparticles; Particle Size; Polyethylene Glycols; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2021 |
Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation.
Topics: Acetaminophen; Actins; Caveolin 1; Cell Line; Extracellular Matrix; Gene Expression Regulation; Hepatocytes; Humans; Liver; Liver Cirrhosis; Methotrexate; MicroRNAs | 2021 |