acetaminophen and metformin

acetaminophen has been researched along with metformin in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.63)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (15.79)	29.6817
2010's	28 (73.68)	24.3611
2020's	3 (7.89)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Knell, AJ	1
Artini, PG; Genazzani, AR; Monteleone, P; Papini, F	1
Bleumink, R; Boon, L; Fiechter, D; Hassing, I; Kwast, LM; Ludwig, IS; Pieters, RH	1
Casettari, L; Castagnino, E; Cespi, M	1
Fey, SJ; Wrzesinski, K	1
Li, L; Mao, S; Ni, R; Shao, Y; Wang, L; Zhang, T	1
Choi, DH; Choi, HS; Hwang, JH; Kim, DK; Kim, KS; Kim, YH; Lee, CH; Noh, JR; Tadi, S; Yim, YH	1
Feng, K; Gao, H; Hou, L; Schoener, CA; Wu, P	1
Cook, DL; Kavanagh, TJ; Khalil, G; Neal, A; Newham, P; Philips, CW; Rountree, AM; Sweet, IR; Williams, DP	1
Dehpour, AR; Hasanvand, A; Saeedi Saravi, SS; Shahkarami, K	1
Chavan, H; Du, K; Jaeschke, H; Krishnamurthy, P; Ramachandran, A; Weemhoff, JL; Xie, Y	1
Batra, A; Desai, D; Serajuddin, ATM	1
Bezuijen, A; De Beer, T; De Jaeghere, W; Grymonpré, W; Remon, JP; Stauffer, F; Vanhoorne, V; Vercruysse, J; Verstraete, G; Vervaet, C	1
Benyerbah, N; Ispas-Szabo, P; Mateescu, MA; Sakeer, K	1
Young, CKJ; Young, MJ	1
Hoffman, RS; Manini, AF; Taub, ES	1
Bissoyi, A; Garg, G; Kumar, R; Rizvi, SI; Singh, AK; Singh, S; Tripathi, SS; Verma, AK	1
Boone, M; De Beer, T; De Coninck, E; De Geest, BG; Elmahdy, A; Markl, D; Van Assche, G; Vanhoorne, V; Vervaet, C	1
Batra, A; Desai, D; Serajuddin, ATM; Thongsukmak, A	1
Chen, GF; Chen, WH; Ho, MC; Yang, RY	1

Reviews

2 review(s) available for acetaminophen and metformin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacotherapy of ovarian hyperstimulation syndrome. Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:15 Topics: Acetaminophen; Animals; Female; Hormone Antagonists; Humans; Metformin; Ovarian Hyperstimulation Syndrome; Reproductive Techniques, Assisted	2010

Other Studies

36 other study(ies) available for acetaminophen and metformin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Antidiuretic and hypoglycaemic activity. British medical journal, 1971, Mar-13, Volume: 1, Issue:5749 Topics: Acetaminophen; Aminopyrine; Chlorpropamide; Diuresis; Drug Synergism; Hypoglycemic Agents; Metformin; Models, Chemical; Vasopressins	1971
Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 121, Issue:2 Topics: Acetaminophen; Acetanilides; Adjuvants, Immunologic; Administration, Oral; Animals; Antibody Formation; Carbamazepine; Drug Evaluation, Preclinical; Drug Hypersensitivity; Female; Injections, Epidural; Local Lymph Node Assay; Metformin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Ofloxacin; Ovalbumin	2011
Evaluation of dibutyrylchitin as new excipient for sustained drug release. Drug development and industrial pharmacy, 2012, Volume: 38, Issue:8 Topics: Acetaminophen; Cellulose; Chemistry, Pharmaceutical; Chitin; Delayed-Action Preparations; Excipients; Hypromellose Derivatives; Lactose; Mesylates; Metformin; Methylcellulose; Pharmaceutical Preparations; Povidone; Starch; Tablets	2012
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line. Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 127, Issue:2 Topics: Acetaminophen; Adenosine Triphosphate; Amiodarone; Bioreactors; Diclofenac; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Lethal Dose 50; Metformin; Phenformin; Proteins; Reproducibility of Results; Risk Assessment; Spheroids, Cellular; Toxicity Tests; Valproic Acid	2012
Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film. International journal of pharmaceutics, 2013, Jun-25, Volume: 450, Issue:1-2 Topics: Acetaminophen; Alginates; Cellulose; Chitosan; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Metformin; Osmolar Concentration; Stearic Acids; Tablets; Theophylline; Trimetazidine	2013
Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. Journal of hepatology, 2015, Volume: 63, Issue:1 Topics: Acetaminophen; Animals; Antigens, Differentiation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatocytes; Hypoglycemic Agents; JNK Mitogen-Activated Protein Kinases; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction	2015
Exploring the drug migration process through ethyl cellulose-based films from infrared-spectral insights. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2015, Volume: 93 Topics: Acetaminophen; Cellulose; Diffusion; Drug Carriers; Kinetics; Metformin; Osmotic Pressure; Plasticizers; Porosity; Solubility; Solvents; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Water	2015
Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate. Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 148, Issue:2 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Liver; Metformin; Models, Biological; Oxygen Consumption; Rats, Sprague-Dawley; Recovery of Function; Risk Assessment; Toxicity Tests	2015
The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB/C mice. Pharmaceutical biology, 2016, Volume: 54, Issue:12 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred BALB C; Protective Agents; Random Allocation	2016
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 154, Issue:2 Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Enzyme Activation; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Male; Metformin; Mice, Inbred C57BL; Mitochondria, Liver; Necrosis; Oxidative Stress; Time Factors	2016
Investigating the Use of Polymeric Binders in Twin Screw Melt Granulation Process for Improving Compactibility of Drugs. Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Cellulose; Drug Compounding; Excipients; Hypoglycemic Agents; Hypromellose Derivatives; Metformin; Methacrylates; Polymers; Polymethacrylic Acids; Povidone; Solubility; Tablets; Tensile Strength	2017
The use of partially hydrolysed polyvinyl alcohol for the production of high drug-loaded sustained release pellets via extrusion-spheronisation and coating: In vitro and in vivo evaluation. International journal of pharmaceutics, 2017, Jan-30, Volume: 517, Issue:1-2 Topics: Acetaminophen; Animals; Cellulose; Delayed-Action Preparations; Dogs; Drug Carriers; Drug Compounding; Drug Liberation; Male; Metformin; Particle Size; Polyvinyl Alcohol; Surface Properties; Technology, Pharmaceutical	2017
From the Editor's Desk, Editor's Highlights, Letters to the Editor. Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 154, Issue:2 Topics: Acetaminophen; Flame Retardants; Humans; Metformin; Models, Biological; Toxicity Tests; Toxicology	2016
Ampholytic starch excipients for high loaded drug formulations: Mechanistic insights. International journal of pharmaceutics, 2018, Jan-15, Volume: 535, Issue:1-2 Topics: Acetaminophen; Aspirin; Drug Compounding; Excipients; Mesalamine; Metformin; Starch; Tablets; Viscosity	2018
Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:4 Topics: Acetaminophen; Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Culture Media; Energy Metabolism; Glycolysis; Hepatocytes; Humans; L-Lactate Dehydrogenase; Lactic Acid; Liver Neoplasms; Metformin; Oxidative Phosphorylation	2019
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. The American journal of emergency medicine, 2019, Volume: 37, Issue:12 Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emergency Service, Hospital; Female; Humans; Hyperlactatemia; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Middle Aged; Prospective Studies; Retrospective Studies; Risk Factors	2019
Metformin ameliorates acetaminophen-induced sub-acute toxicity via antioxidant property. Drug and chemical toxicology, 2022, Volume: 45, Issue:1 Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Male; Metformin; Oxidative Stress; Rats; Rats, Wistar	2022
Prilling of API/fatty acid suspensions: Processability and characterisation. International journal of pharmaceutics, 2019, Dec-15, Volume: 572 Topics: Acetaminophen; Crystallization; Drug Compounding; Drug Liberation; Excipients; Fatty Acids; Metformin; Particle Size; Solubility; Spectrum Analysis, Raman; Suspensions	2019
The Effect of Process Variables and Binder Concentration on Tabletability of Metformin Hydrochloride and Acetaminophen Granules Produced by Twin Screw Melt Granulation with Different Polymeric Binders. AAPS PharmSciTech, 2021, May-13, Volume: 22, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Drug Compounding; Freezing; Hypoglycemic Agents; Metformin; Particle Size; Polymers; Tablets; Tensile Strength	2021
The effect of metformin and drinking water quality variation on haloacetamide formation during chlor(am)ination of acetaminophen. Journal of environmental management, 2023, Jun-01, Volume: 335 Topics: Acetaminophen; Chlorine; Disinfectants; Disinfection; Drinking Water; Halogenation; Metformin; Pharmaceutical Preparations; Water Pollutants, Chemical; Water Purification	2023