acetaminophen and lignans

acetaminophen has been researched along with lignans in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's2 (10.00)18.2507
2000's2 (10.00)29.6817
2010's9 (45.00)24.3611
2020's6 (30.00)2.80

Authors

AuthorsStudies
Liu, GT1
Liu, GT; Wei, HL1
Kawasaki, H; Murawaki, Y; Yamada, S1
Bachleda, P; Dvorák, Z; Kosina, P; Simánek, V; Ulrichová, J; Walterová, D1
Chang, YC; Chen, YH; Chiu, JH; Ho, YY; Hong, CY; Huang, YT; Lai, MT; Lin, FY; Liu, PL; Man, KM1
Hwang, SJ; Kay, HY; Kim, SG; Kim, YW; Ryu, DH; Sung, SH1
Chen, Y; Li, L; Xin, Y; Xing, G; Zhang, T; Zhou, L1
Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H1
Guo, L; He, CJ; He, YC; Liu, JL; Peng, C; Xie, XF; Xiong, L; Zou, Y1
Bi, H; Chen, P; Fan, X; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H1
Bi, H; Chen, P; Chen, Y; Fan, X; Huang, M; Jiang, Y; Li, D; Li, X; Qin, X; Tan, H; Wang, Y; Zeng, H; Zeng, X; Zhou, Y1
Bi, HC; Chen, P; Fan, XM; Huang, M; Jiang, YM; Tan, HS; Wang, Y; Yu, T; Zeng, H1
Chen, MH; Li, R; Li, YC; Lin, S; Liu, W; Qu, YH; Sun, H; Wang, LY; Wang, SJ; Wu, J; Wu, YZ; Zhang, D1
Wu, JW; Yu, FL; Zhu, H1
Li, S; Qi, XZ; Shao, SY; Sun, H1
Ding, Q; Du, Y; Guo, H; Hu, K; Huang, H; Kang, D; Li, C; Liang, Y; Shao, Y; Wang, G; Wang, H; Xie, L; Yan, C; Yu, T1
Cao, L; Cheng, S; Iqbal Choudhary, M; Jia, Y; Jian, Y; Li, B; Liu, Y; Peng, C; Rahman, AU; Wang, W; Yang, Y; Yu, H1
Deng, S; Ge, J; Li, J; Li, M; Li, X; Ma, L; Ma, Y; Zhang, J; Zheng, Y1
Cao, Y; Cheng, L; Gao, Z; Wang, L; Wang, T; Wu, W; Zhang, Q1
Gao, GC; Gao, JL; Li, C; Lin, QY; Liu, SH; Ru, YJ; Wang, L; Wu, JM; Yang, YD; Zhang, XQ; Zheng, CW; Zheng, YX1

Reviews

1 review(s) available for acetaminophen and lignans

ArticleYear
Effects of some compounds isolated from Chinese medicinal herbs on hepatic microsomal cytochrome P-450 and their potential biological consequences.
    Drug metabolism reviews, 1991, Volume: 23, Issue:3-4

    Topics: Acetaminophen; Alkaloids; Animals; Carbon Tetrachloride; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Enzyme Induction; Humans; Isoquinolines; Lignans; Lignin; Liver

1991

Other Studies

19 other study(ies) available for acetaminophen and lignans

ArticleYear
[Protection by fructus Schizandrae against acetaminophen hepatotoxicity in mice].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1987, Volume: 22, Issue:9

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glutathione; Lignans; Liver; Male; Mice; Microsomes, Liver; Polycyclic Compounds

1987
Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats.
    Biochemical pharmacology, 1993, Sep-14, Volume: 46, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glutathione; Lignans; Lipid Peroxides; Liver; Liver Diseases; Male; Organ Size; Rats; Rats, Wistar; Time Factors

1993
Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum.
    Toxicology letters, 2003, Feb-03, Volume: 137, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Asteraceae; Biphenyl Compounds; Cell Separation; Cell Survival; Cells, Cultured; Flavonoids; Free Radical Scavengers; Galactosamine; Hepatocytes; Humans; L-Lactate Dehydrogenase; Lignans; Picrates; Plant Extracts; Propanols; Protein Biosynthesis; tert-Butylhydroperoxide; Toxins, Biological

2003
Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats.
    Archives of pharmacal research, 2009, Volume: 32, Issue:2

    Topics: Acetaminophen; Animals; Antioxidants; Biphenyl Compounds; Glutathione; Lignans; Lipid Peroxidation; Liver; Liver Failure, Acute; Magnolia; Male; Rats; Rats, Sprague-Dawley

2009
Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.
    British journal of pharmacology, 2011, Volume: 163, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Benzopyrans; Dioxoles; Glutathione; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Lignans; Liver; Major Histocompatibility Complex; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Phytotherapy; Plant Preparations; Protective Agents; Protein Kinase C-delta; Proteins; Saururaceae; Signal Transduction; Vesicular Transport Proteins

2011
Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:3

    Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Lignans; Liver; Male; Mice; Phytotherapy; Polycyclic Compounds; Schisandra; Time Factors

2014
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis Regulatory Proteins; Benzoquinones; Binding Sites; Biomarkers; Catalytic Domain; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytoprotection; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Imines; Lignans; Liver; Liver Regeneration; Male; Membrane Proteins; Mice, Inbred C57BL; Mitochondria, Liver; Molecular Docking Simulation; Protein Binding; Protein Conformation; Signal Transduction

2015
Penthorin A and B, two unusual 2,4'-epoxy-8,5'-neolignans from Penthorum chinese.
    Fitoterapia, 2015, Volume: 100

    Topics: Acetaminophen; Cell Line; Hepatocytes; Humans; Lignans; Molecular Structure; Saxifragaceae

2015
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
    Chemico-biological interactions, 2015, Apr-25, Volume: 231

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dioxoles; Lignans; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Polycyclic Compounds; Protective Agents; Schisandra

2015
Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Glucuronosyltransferase; Lignans; Lithocholic Acid; Liver; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Pregnane X Receptor; Protective Agents; Receptors, Steroid; Schisandra; Signal Transduction

2016
Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidant Response Elements; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Gene Expression Regulation; Hep G2 Cells; Humans; Lignans; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Protective Agents; RNA, Messenger; Schisandra; Signal Transduction

2016
Bioactive Glycosides from the Twigs of Litsea cubeba.
    Journal of natural products, 2017, 06-23, Volume: 80, Issue:6

    Topics: Acetaminophen; Algorithms; Crystallography, X-Ray; Drugs, Chinese Herbal; Glycosides; Hep G2 Cells; Humans; Inhibitory Concentration 50; Lignans; Lipopolysaccharides; Litsea; Molecular Conformation; Molecular Structure; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plant Stems

2017
Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.
    Life sciences, 2019, Aug-01, Volume: 230

    Topics: Acetaminophen; Animals; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Glutathione; Lignans; Liver; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Signal Transduction

2019
Hepatoprotective lignans and triterpenoids from the roots of Kadsura longipedunculata.
    Fitoterapia, 2020, Volume: 142

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Hep G2 Cells; Hepatocytes; Humans; Kadsura; Lignans; Molecular Structure; Plant Roots; Triterpenes

2020
Multiomics Profiling Reveals Protective Function of
    Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 48, Issue:10

    Topics: Acetaminophen; Administration, Oral; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Diglycerides; Disease Models, Animal; Drugs, Chinese Herbal; Hepatocytes; Humans; Lignans; Lipid Metabolism; Lipidomics; Liver; Male; Mice; Primary Cell Culture; Protective Agents; Protein Kinase C; Proteomics; Schisandra; Triglycerides

2020
Dibenzocyclooctadiene lignans from Kadsura coccinea alleviate APAP-induced hepatotoxicity via oxidative stress inhibition and activating the Nrf2 pathway in vitro.
    Bioorganic chemistry, 2021, Volume: 115

    Topics: Acetaminophen; Cell Survival; Cyclooctanes; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Kadsura; Lignans; Molecular Structure; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Structure-Activity Relationship

2021
Network pharmacology, molecular docking technology integrated with pharmacodynamic study to reveal the potential targets of Schisandrol A in drug-induced liver injury by acetaminophen.
    Bioorganic chemistry, 2022, Volume: 118

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dose-Response Relationship, Drug; Lignans; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship

2022
Study on the Protective Effect of Schizandrin B against Acetaminophen-Induced Cytotoxicity in Human Hepatocyte.
    Biological & pharmaceutical bulletin, 2022, Volume: 45, Issue:5

    Topics: Acetaminophen; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Cyclooctanes; Hepatocytes; Humans; Lignans; Mitogen-Activated Protein Kinase Kinases; Polycyclic Compounds

2022
Schisantherin D from Schisandra chinensis (Turcz.) Baill. exhibits anti-liver fibrosis capacity via modulating ETBR involved signaling, an in vitro and in vivo study.
    Fitoterapia, 2022, Volume: 162

    Topics: Acetaminophen; Aflatoxin B1; Animals; Dioxoles; Humans; Lignans; Liver Cirrhosis; Mice; Molecular Structure; NF-E2-Related Factor 2; Receptor, Endothelin B; Schisandra; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2022