acetaminophen and isoniazid

acetaminophen has been researched along with isoniazid in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (36.36)	18.7374
1990's	15 (19.48)	18.2507
2000's	8 (10.39)	29.6817
2010's	25 (32.47)	24.3611
2020's	1 (1.30)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bharate, SS; Vishwakarma, RA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Benhamou, JP; Pessayre, D	1
Mitchell, JR; Potter, WZ	1
Dybing, E; Mitchell, JR	1
Black, M	1
Connor, TH; Forti, GC; Legator, MS; Sitra, P	1
Rosenoer, VM; Tornay, AS	1
Sherlock, S	1
Lauterburg, BH; Mitchell, JR	1
Dybing, E; McMurtry, RJ; Mitchell, JR; Nelson, SD; Thorgeirsson, SS	1
Adjepon-Yamoah, KK; Finlayson, ND; Forrest, JA; Prescott, LF	1
Gillette, JR; Mitchell, JR; Snodgrass, WR	1
Jollows, DJ; Mitchell, JR	1
Lovering, EG; McGilveray, IJ; McMillan, I; Tostowaryk, W	1
Dybing, E	1
Awad, JA; Badr, KF; Burk, RF; Kato, T; Morrow, JD; Roberts, LJ; Takahashi, K	1
Apostolakis, JC; Georgiou, CA; Koupparis, MA	1
Kanel, GC; Moulding, TS; Redeker, AG	1
Epstein, MM; Kalhorn, TF; Nelson, SD; Slattery, JT; Wall, RA; Wright, JM	1
Burk, RF; Hill, KE; Hunt, RW; Martin, AE	1
Murphy, R; Swartz, R; Watkins, PB	1
Støttum, A; Wiger, R	1
Mehta, S	2
Hirayama, C; Yamamoto, T	1
Lauterburg, BH	1
Hennigar, GR	1
Bloor, JR; Morrison, JC	1
Ganshorn, A; Kurz, H	1
Gault, MH; Hebert, MA; Singh, HP	1
Abernethy, DR; Greenblatt, DJ; Knüchel, M; Ochs, HR; Verburg-Ochs, B	1
Gillette, JR	1
Salaspuro, M	1
Kern, F; Mallory, A	1
Thaler, H	1
Nelson, SD; Nolan, CM; Sandblom, RE; Slattery, JT; Thummel, KE	1
Heathcote, J; Wanless, IR	1
Adams, SP; Kalhorn, TF; Nelson, SD; Slattery, JT; Thummel, KE; Wright, JM; Zand, R	1
Crippin, JS	1
Jacqueson, A; Nicod, L; Regnier, A; Richert, L; Viollon, C	1
Carithers, RL; Chien, JY; Nelson, SD; Nolan, CM; Peter, RM; Slattery, JT; Thummel, KE; Wartell, C	1
Chien, JY; Slattery, JT; Thummel, KE	1
Murthy, KC; Nagaraja, P; Rangappa, KS	1
Gopumadhavan, S; Mitra, SK; Sundaram, R; Venkataranganna, MV	1
Abraham, AM; Barr, S; Coetsee, C; Walubo, A	1
Maddrey, WC	1
Hirano, K; Iguchi, K; Kiho, T; Kubota, M; Shinoda, A; Takahashi, Y; Usui, S	1
Lewis, JH; Liss, G; Rattan, S	1
Kessebohm, K; Lauterburg, B; Stirnimann, G	1
Abenavoli, L; Bosco, D; Gallo, D; Libri, E; Luzza, F	1
Basit, A; Iqbal, Z; Khan, AA; Nureen, H	1
Dygai, AM; Udut, VV; Vengerovsky, AI	1
Gong, Z; Li, C; Zhang, X	1
Cui, L; Pu, K; Rao, J; Shuhendler, AJ; Uetrecht, JP	1
Ambroso, JI; Brown, HR; Falls, JG; Hunt, CM; Ilic, K; Miller, RT; Reese, MJ; Suzuki, A; Yuen, NA	1
Ma, C; Shen, S; Wang, J; Xu, J; Zhao, L; Zhou, EM	1
Banks, CE; Khairy, M; Mahmoud, BG; Rashwan, FA	1
Cao, L; Greenblatt, DJ; Kwara, A	1
Ehrich, MF; Orbach, SM; Rajagopalan, P	1
Jiang, X; Li, Y; Zhang, H; Zhang, J; Zhang, Y	1
Baumann, L; Braunbeck, T; Hennies, M; Holbech, H; Moissl, AP; Schmidt-Posthaus, H; Segner, H; Tiedemann, J; Weltje, L	1

Reviews

15 review(s) available for acetaminophen and isoniazid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug metabolism in the production of liver injury. The Medical clinics of North America, 1975, Volume: 59, Issue:4 Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Drug Hypersensitivity; Ethers; Furosemide; Glutathione; Halothane; Humans; Inactivation, Metabolic; Isoniazid; Liver; Liver Neoplasms; Necrosis; Pharmaceutical Preparations; Phenacetin; Protein Binding; Thiophenes	1975
Hepatotoxicity: pathogenesis and therapeutic intervention. Clinics in gastroenterology, 1979, Volume: 8, Issue:1 Topics: Acetaminophen; Anabolic Agents; Androgens; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Erythromycin; Estrogens; Halothane; Humans; Isoniazid; Liver; Nitrofurantoin; Rifampin	1979
Metabolic activation: biochemical basis for many drug-induced liver injuries. Progress in liver diseases, 1976, Volume: 5 Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hydrazines; Isoniazid; Liver; Methyldopa; Necrosis; Pharmaceutical Preparations; Phenacetin; Thiophenes	1976
Drug metabolism in liver disease. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; Half-Life; Humans; Isoniazid; Lidocaine; Liver; Liver Diseases; Pharmaceutical Preparations; Tolbutamide	1975
[Intermediate metabolites and liver toxicity]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6 Topics: Acetaminophen; Animals; Aspirin; Chlorpromazine; Halothane; Humans; Inactivation, Metabolic; Isoniazid; Liver; Methyldopa; Rats	1985
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics]. Schweizerische medizinische Wochenschrift, 1985, Sep-21, Volume: 115, Issue:38 Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Glutathione; Halothane; Humans; Isoniazid; Liver; Perhexiline; Valproic Acid	1985
Drug disposition in children with protein energy malnutrition. Journal of pediatric gastroenterology and nutrition, 1983, Volume: 2, Issue:3 Topics: Acetaminophen; Antipyrine; Biological Availability; Biotransformation; Child; Child, Preschool; Chloramphenicol; Gentamicins; Humans; Infant; Isoniazid; Kidney; Liver; Penicillins; Pharmaceutical Preparations; Protein-Energy Malnutrition; Sulfadiazine; Tissue Distribution	1983
The problem of chemically reactive metabolites. Drug metabolism reviews, 1982, Volume: 13, Issue:6 Topics: Acetaminophen; Animals; Biotransformation; Chemical Phenomena; Chemistry; Chloroform; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Isoniazid; Kinetics; Pharmaceutical Preparations; Terpenes	1982
Drug-induced pancreatitis: a critical review. Gastroenterology, 1980, Volume: 78, Issue:4 Topics: Acetaminophen; Adrenal Cortex Hormones; Amphetamines; Asparaginase; Azathioprine; Chlorthalidone; Cholestyramine Resin; Cimetidine; Cyproheptadine; Dextropropoxyphene; Diazoxide; Diuretics; Estrogens; Ethacrynic Acid; Furosemide; Histamine; Humans; Hypercalcemia; Indomethacin; Isoniazid; Mercaptopurine; Narcotics; Pancreatitis; Phenformin; Procainamide; Rifampin; Salicylates; Sodium Chloride Symporter Inhibitors; Sulfonamides; Tetracycline	1980
Hepatotoxicity: newer aspects of pathogenesis and treatment. The Gastroenterologist, 1995, Volume: 3, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Contraceptives, Oral; Female; Humans; Isoniazid; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Male; Nonprescription Drugs; Propylthiouracil; Rifampin	1995
Drug-induced hepatotoxicity: 2005. Journal of clinical gastroenterology, 2005, Volume: 39, Issue:4 Suppl 2 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chromans; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoniazid; Kava; Liver; Male; Minocycline; Polymorphism, Genetic; Risk Assessment; Risk Factors; Thiazolidinediones; Troglitazone; Vitamin A	2005
Predicting and preventing acute drug-induced liver injury: what's new in 2010? Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:9 Topics: Acetaminophen; Adult; Aged; Aging; Alanine Transaminase; Amoxicillin-Potassium Clavulanate Combination; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antitubercular Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Predisposition to Disease; Humans; Isoniazid; Male; Middle Aged; Pharmaceutical Preparations; Risk Factors	2010
Liver injury caused by drugs: an update. Swiss medical weekly, 2010, Volume: 140 Topics: Acetaminophen; Adaptive Immunity; Analgesics, Non-Narcotic; Antitubercular Agents; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome Reductases; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Genetic Predisposition to Disease; Genome-Wide Association Study; Homeostasis; Humans; Immunity, Innate; Inactivation, Metabolic; Isoniazid; Lipid Peroxidation; Liver; Metabolic Clearance Rate; Mitochondria, Liver; Oxidative Stress; Pharmaceutical Preparations; Polymorphism, Genetic; Risk Factors	2010
[Drug-induced liver injury]. Recenti progressi in medicina, 2012, Volume: 103, Issue:2 Topics: Acetaminophen; Algorithms; Amoxicillin; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hypnotics and Sedatives; Isoniazid; Kava; Liver Failure, Acute; Risk Factors; Severity of Illness Index; Sulfonamides	2012

Trials

1 trial(s) available for acetaminophen and isoniazid

Article	Year
Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid. Clinical pharmacology and therapeutics, 1997, Volume: 61, Issue:1 Topics: Acetaminophen; Acetylation; Adult; Analgesics, Non-Narcotic; Antitubercular Agents; Arylamine N-Acetyltransferase; Cytochrome P-450 CYP2E1; Drug Administration Schedule; Genotype; Humans; Isoniazid; Middle Aged; Phenotype; Polymorphism, Genetic	1997

Article

Year

Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid.

Clinical pharmacology and therapeutics, 1997, Volume: 61, Issue:1

Topics: Acetaminophen; Acetylation; Adult; Analgesics, Non-Narcotic; Antitubercular Agents; Arylamine N-Acetyltransferase; Cytochrome P-450 CYP2E1; Drug Administration Schedule; Genotype; Humans; Isoniazid; Middle Aged; Phenotype; Polymorphism, Genetic

1997

Other Studies

61 other study(ies) available for acetaminophen and isoniazid

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7 Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics	2015
[Reactive metabolites of xenobiotics : their role in the hepatotoxicity of drugs]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1979, Volume: 173, Issue:2 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycolates; Humans; Hydrazines; Isoniazid; Monoamine Oxidase Inhibitors; Pharmaceutical Preparations; Rifampin	1979
The role of metabolic activation for drug-induced liver injuries. Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Isoniazid; Liver; Methyldopa	1977
Bile as a source of mutagenic metabolites produced in vivo and detected by Salmonella typhimurium. Environmental mutagenesis, 1979, Volume: 1, Issue:3 Topics: Acetaminophen; Animals; Bile; Biotransformation; Cyclophosphamide; Diethylstilbestrol; Dimethylnitrosamine; Ethylene Dichlorides; Hycanthone; Isoniazid; Male; Methyl Methanesulfonate; Methylcholanthrene; Mutagens; Rats; Salmonella typhimurium; Serum Albumin, Bovine	1979
Drugs and the liver. The Medical clinics of North America, 1979, Volume: 63, Issue:2 Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptives, Oral; Drug Hypersensitivity; Female; Halothane; Humans; Isoniazid; Liver; Liver Neoplasms; Methotrexate; Pharmaceutical Preparations; Tetracycline	1979
Hepatic reactions to drugs. Gut, 1979, Volume: 20, Issue:7 Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Female; Halothane; Humans; Isoniazid; Liver; Liver Neoplasms; Male; Pregnancy	1979
Drug-induced liver injury. Hospital practice, 1978, Volume: 13, Issue:9 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Halothane; Humans; Isoniazid; Liver; Methyldopa; Mice	1978
The role of biotransformation in chemical-induced liver injury. Environmental health perspectives, 1976, Volume: 15 Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cricetinae; Furosemide; Glutathione; Guinea Pigs; Humans; In Vitro Techniques; Iproniazid; Isoniazid; Liver Diseases; Methylcholanthrene; Mice; Phenobarbital; Rats	1976
Progress in hepatology. Metabolic activation of drugs to toxic substances. Gastroenterology, 1975, Volume: 68, Issue:2 Topics: Acetaminophen; Animals; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cricetinae; Furosemide; Hemolysis; Humans; Isoniazid; Kidney Diseases; Kinetics; Liver; Lung Diseases; Mice; Protein Binding; Toxicology; Tritium	1975
Comparative bioavailabilities from truncated blood level curves. Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:9 Topics: Acetaminophen; Aminosalicylic Acids; Biological Availability; Biopharmaceutics; Chloramphenicol; Chlordiazepoxide; Digoxin; Humans; Isoniazid; Kinetics; Pharmaceutical Preparations; Phenylbutazone; Sulfamethizole; Tetracycline; Time Factors; Warfarin	1975
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Isoniazid; Liver; Methyldopa; Necrosis	1976
Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. The Journal of clinical investigation, 1992, Volume: 90, Issue:6 Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Indomethacin; Isoniazid; Lipid Peroxides; Male; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Thioacetamide	1992
Use of ion-selective electrodes in kinetic flow injection: determination of phenolic and hydrazino drugs with 1-fluoro-2,4-dinitrobenzene using a fluoride-selective electrode. The Analyst, 1991, Volume: 116, Issue:3 Topics: Acetaminophen; Dinitrofluorobenzene; Electrodes; Hydrazines; Isoniazid; Isoxsuprine; Phenols; Potentiometry	1991
Acetaminophen, isoniazid, and hepatic toxicity. Annals of internal medicine, 1991, Mar-01, Volume: 114, Issue:5 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoniazid	1991
Inhibition of the metabolism of paracetamol by isoniazid. British journal of clinical pharmacology, 1991, Volume: 31, Issue:2 Topics: Acetaminophen; Acetylation; Adult; Catechols; Female; Glutathione; Humans; Isoniazid; Male; Middle Aged; Oxidation-Reduction; Phenotype	1991
Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it. Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Glutathione; Isoniazid; Liver; Male; Phenobarbital; Pyrazoles; Rats; Rats, Inbred F344	1990
Severe acetaminophen toxicity in a patient receiving isoniazid. Annals of internal medicine, 1990, Nov-15, Volume: 113, Issue:10 Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Interactions; Drug Overdose; Enzyme Induction; Female; Humans; Isoniazid; Oxidoreductases, N-Demethylating; Suicide, Attempted	1990
In vitro testing for developmental toxicity using the Hydra attenuata assay. NIPH annals, 1985, Volume: 8, Issue:2 Topics: Acetaminophen; Animals; Dimethyl Sulfoxide; Ethanol; Hexachlorocyclohexane; Hydra; Isoniazid; Regeneration; Teratogens; Toxicology; Valproic Acid	1985
Drug induced hepatic damage. Indian pediatrics, 1988, Volume: 25, Issue:5 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Hypersensitivity; Humans; Infant; Isoniazid; Rifampin	1988
Iatrogenic drug toxicity. Monographs in pathology, 1985, Issue:26 Topics: Acetaminophen; Age Factors; Amphotericin B; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Hemolysis; Humans; Isoniazid; Kidney Diseases; Methotrexate; Pharmaceutical Preparations; Probability; Time Factors	1985
Effects of solubilization on drug diffusion. The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:12 Topics: Acetaminophen; Amphetamine; Biophysical Phenomena; Biophysics; Chemical Phenomena; Chemistry, Physical; Chloramphenicol; Detergents; Diffusion; Ephedrine; Glycols; Isoniazid; Pharmaceutical Preparations; Solubility; Spectrophotometry; Sulfathiazoles; Surface-Active Agents; Viscosity	1972
[Differences between the protein binding of newborns and adults and their importance for pharmacological action]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2 Topics: Acetaminophen; Age Factors; Aminosalicylic Acids; Atropine; Chloramphenicol; Humans; Infant, Newborn; Isoniazid; Methicillin; Morphine; Nitrofurantoin; Oxyphenbutazone; Phenacetin; Phenobarbital; Phenytoin; Promethazine; Protein Binding; Salicylates; Sulfadimethoxine; Thiopental	1968
Effect of some drugs on clinical laboratory values as determined by the Technicon SMA 12-60. Clinical chemistry, 1972, Volume: 18, Issue:2 Topics: Acetaminophen; Alkaline Phosphatase; Aminosalicylic Acids; Ascorbic Acid; Aspartate Aminotransferases; Autoanalysis; Bilirubin; Blood Chemical Analysis; Blood Glucose; Chemical Phenomena; Chemistry; Cholesterol; Clinical Laboratory Techniques; Dihydroxyphenylalanine; Evaluation Studies as Topic; Humans; Isoniazid; L-Lactate Dehydrogenase; Mercaptopurine; Methyldopa; Pharmaceutical Preparations; Spectrophotometry; Sulfathiazoles; Uric Acid	1972
Differential effects of isoniazid and oral contraceptive steroids on antipyrine oxidation and acetaminophen conjugation. Pharmacology, 1984, Volume: 28, Issue:4 Topics: Acetaminophen; Adult; Antipyrine; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Interactions; Female; Half-Life; Humans; Isoniazid; Liver; Male; Oxidation-Reduction	1984
[Drug-induced liver damage; new aspects on its mechanism]. Duodecim; laaketieteellinen aikakauskirja, 1980, Volume: 96, Issue:5 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Estrogens; Female; Halothane; Humans; Isoniazid; Liver; Methyldopa; Oxyphenisatin Acetate	1980
Iatrogenic toxic liver disease. The Tokai journal of experimental and clinical medicine, 1982, Volume: 7, Issue:6 Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Enzyme Induction; Humans; Isoniazid; Lipid Peroxides; Liver; Macromolecular Substances	1982
Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. Chest, 1994, Volume: 105, Issue:2 Topics: Acetaminophen; Adult; Capreomycin; Ciprofloxacin; Drug Combinations; Drug Overdose; Ethambutol; Female; Humans; Isoniazid; Liver; Pyrazinamide; Rifampin; Streptomycin; Tuberculosis; Tuberculosis, Lymph Node; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary	1994
Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans. Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:2 Topics: Acetaminophen; Acetylation; Adult; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Isoniazid; Male; Middle Aged; Oxidoreductases, N-Demethylating; Phenotype; Sulfamethazine	1993
Acetaminophen hepatotoxicity: potentiation by isoniazid. The American journal of gastroenterology, 1993, Volume: 88, Issue:4 Topics: Acetaminophen; Adult; Drug Synergism; Drug Therapy, Combination; Female; Humans; Isoniazid; Liver	1993
Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells. Human & experimental toxicology, 1997, Volume: 16, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Carcinoma, Hepatocellular; Cell Survival; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Humans; Isoniazid; Liver Neoplasms; Methylcholanthrene; Rifampin; Tumor Cells, Cultured	1997
Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:10 Topics: Acetaminophen; Animals; Computer Simulation; Cytochrome P-450 CYP2E1; Drug Interactions; Enzyme Activation; Enzyme Induction; Humans; Isoniazid; Liver; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics	1997
Spectrophotometric method for the determination of paracetamol and phenacetin. Journal of pharmaceutical and biomedical analysis, 1998, Volume: 17, Issue:3 Topics: Acetaminophen; Alkalies; Analgesics, Non-Narcotic; Drug Stability; Hydrolysis; Isoniazid; Naphthoquinones; Phenacetin; Spectrophotometry	1998
Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. Journal of ethnopharmacology, 1998, Volume: 63, Issue:3 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Isoniazid; Liver Function Tests; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Thioacetamide	1998
The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. Human & experimental toxicology, 2004, Volume: 23, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Drug Overdose; Enzyme Inhibitors; Isoniazid; Ketoconazole; Male; Rats; Rats, Sprague-Dawley	2004
Up-regulation of the lysyl hydroxylase 2 gene by acetaminophen and isoniazid is modulated by transcription factor c-Myb. The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:4 Topics: Acetaminophen; Binding Sites; Blotting, Western; Chemical and Drug Induced Liver Injury; Fibrosis; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hep G2 Cells; Humans; Isoniazid; Liver; Mutation; Plasmids; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myb; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation; Transfection; Up-Regulation	2010
Effect of paracetamol on pharmacokinetics of isoniazid in Teddy goats. Pakistan journal of pharmaceutical sciences, 2012, Volume: 25, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antitubercular Agents; Drug Interactions; Goats; Isoniazid	2012
Effects of phospholipid hepatoprotectors on apoptosis during experimental liver pathology induced by isoniazid and paracetamol. Bulletin of experimental biology and medicine, 2013, Volume: 154, Issue:5 Topics: Acetaminophen; Alkaline Phosphatase; Animals; Apoptosis; Bilirubin; Carotenoids; Chemical and Drug Induced Liver Injury; Drug Combinations; Granulocytes; Interleukin-10; Isoniazid; Liver Function Tests; Lymphocytes; Male; Phosphatidylcholines; Phospholipids; Rats; Succinic Acid; Transaminases; Tumor Necrosis Factor-alpha	2013
Development of a convenient in vivo hepatotoxin assay using a transgenic zebrafish line with liver-specific DsRed expression. PloS one, 2014, Volume: 9, Issue:3 Topics: Acetaminophen; Animals; Animals, Genetically Modified; Aspirin; Hazardous Substances; Humans; Isoniazid; Liver; Luminescent Proteins; Phenylbutazone; Red Fluorescent Protein; Zebrafish	2014
Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nature biotechnology, 2014, Volume: 32, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Fluorescence Resonance Energy Transfer; Isoniazid; Liver; Mice; Mice, Nude; Models, Chemical; Nanoparticles; Nanotechnology; Optical Imaging; Oxidative Stress; Polymers; Reactive Nitrogen Species; Reactive Oxygen Species; Toxicity Tests; Whole Body Imaging	2014
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. Regulatory toxicology and pharmacology : RTP, 2015, Volume: 72, Issue:3 Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Liver Injury; Data Mining; Databases, Factual; Drug Interactions; Isoniazid; Valproic Acid; World Health Organization	2015
On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay. Analytical chemistry, 2016, Feb-02, Volume: 88, Issue:3 Topics: Acetaminophen; Biomimetic Materials; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Hep G2 Cells; Hepatocytes; Humans; Isoniazid; Microfluidic Analytical Techniques; Rifampin; Tissue Engineering	2016
Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms. Analytical chemistry, 2017, 02-07, Volume: 89, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Bismuth; Body Fluids; Catalysis; Chemical and Drug Induced Liver Injury; Electrochemical Techniques; Electrodes; Humans; Isoniazid; Limit of Detection; Liver; Nanotubes; Reproducibility of Results	2017
Inhibitory Effects of Selected Antituberculosis Drugs on Common Human Hepatic Cytochrome P450 and UDP-glucuronosyltransferase Enzymes. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:9 Topics: Acetaminophen; Antitubercular Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diarylquinolines; Enzyme Inhibitors; Ethambutol; Glucuronosyltransferase; Humans; Inhibitory Concentration 50; Isoenzymes; Isoniazid; Kinetics; Liver; Pyrazinamide; Rifabutin	2017
High-throughput toxicity testing of chemicals and mixtures in organotypic multi-cellular cultures of primary human hepatic cells. Toxicology in vitro : an international journal published in association with BIBRA, 2018, Volume: 51 Topics: Acetaminophen; Adult; Aged; Animals; Apoptosis; Caprylates; Cell Culture Techniques; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Interactions; Ethanol; Female; Fluorocarbons; Glutathione; Hepatocytes; High-Throughput Screening Assays; Humans; Isoniazid; Male; Middle Aged; Rats, Inbred Lew; Toxicity Tests	2018
Simultaneous voltammetric determination of acetaminophen and isoniazid using MXene modified screen-printed electrode. Biosensors & bioelectronics, 2019, Apr-01, Volume: 130 Topics: Acetaminophen; Biosensing Techniques; Catalysis; Chemical and Drug Induced Liver Injury; Electrodes; Humans; Isoniazid; Limit of Detection; Reproducibility of Results	2019
Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)? Chemosphere, 2020, Volume: 238 Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Endocrine System; Female; Hepatocytes; Isoniazid; Male; Vitellogenins; Water Pollutants, Chemical; Zebrafish; Zebrafish Proteins	2020