acetaminophen and hydrochlorothiazide

acetaminophen has been researched along with hydrochlorothiazide in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.69)18.7374
1990's3 (7.69)18.2507
2000's14 (35.90)29.6817
2010's17 (43.59)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R1
Andricopulo, AD; Moda, TL; Montanari, CA1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Avdeef, A; Tam, KY1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Akamatsu, M1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Levine, L1
Cook, D1
Nimmo, J; Prescott, LF1
Dressman, JB; Eleftheriou, G; Macheras, P; Reppas, C; Symillides, M1
Dabek-Zlotorzynska, E; Lai, EP1
Cook, ME; Thakur, V; Wallin, JD1
Dluzneski, PR; Guo, JH; Harcum, WW; Skinner, GW; Trumbull, DE1
George, A; Shakib, S1
Balwinski, KM; Mitchell, SA1
Kuzmanić, M; Pavlicević, I; Rumboldt, M; Rumboldt, Z1
Carasek, E; Suchara, EA1
Barceló, D; Jelić, A; Petrović, M1
Ghanam, D; Kleinebudde, P1
Hegazy, MA1
Daharwal, SJ; Singh, VD1
Bananezhad, A; Ganjali, MR; Karimi-Maleh, H; Norouzi, P1
De Beer, T; Grymonpré, W; Remon, JP; Vanhoorne, V; Verstraete, G; Vervaet, C1
De Beer, T; Vanbillemont, B1
da Costa, NF; Macedo, J; Pinto, JF; Vanhoorne, V; Vervaet, C1

Reviews

2 review(s) available for acetaminophen and hydrochlorothiazide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Reported ocular side effects of the ten most frequently prescribed drugs.
    Journal of the American Optometric Association, 1979, Volume: 50, Issue:2

    Topics: Acetaminophen; Ampicillin; Brompheniramine; Codeine; Diazepam; Digoxin; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Eye; Eye Diseases; Female; Furosemide; Humans; Hydrochlorothiazide; Methyldopa; Phenylephrine; Phenylpropanolamine; Pregnancy; Propranolol; Tetracyclines; Triamterene

1979

Trials

2 trial(s) available for acetaminophen and hydrochlorothiazide

ArticleYear
Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs.
    American journal of hypertension, 1999, Volume: 12, Issue:9 Pt 1

    Topics: Acetaminophen; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Pressure; Butanones; Creatinine; Dinoprostone; Diuretics; Drug Interactions; Drug Therapy, Combination; Female; Fosinopril; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Ibuprofen; Middle Aged; Nabumetone; Renal Plasma Flow; Sodium; Sodium Chloride Symporter Inhibitors; Sulindac; Thromboxane B2

1999
Interaction between antihypertensives and NSAIDs in primary care: a controlled trial.
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2008,Fall, Volume: 15, Issue:3

    Topics: Acetaminophen; Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Drug Combinations; Drug Interactions; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Ibuprofen; Lisinopril; Male; Middle Aged; Osteoarthritis; Piroxicam; Prospective Studies

2008

Other Studies

35 other study(ies) available for acetaminophen and hydrochlorothiazide

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
QSAR study on permeability of hydrophobic compounds with artificial membranes.
    Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11

    Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Importance of physicochemical properties for the design of new pesticides.
    Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7

    Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic

2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Canadian experience.
    Pharmacology, 1972, Volume: 8, Issue:1

    Topics: Acetaminophen; Biopharmaceutics; Canada; Chlorothiazide; Dosage Forms; Government Agencies; Humans; Hydrochlorothiazide; Legislation, Drug; Nitrofurantoin; Pharmaceutical Preparations; Phenylbutazone; Sulfamethizole; Time Factors

1972
Generic inequivalence--clinical observations.
    Acta pharmacologica et toxicologica, 1971, Volume: 29 Suppl 3

    Topics: Absorption; Acetaminophen; Administration, Oral; Adult; Aspirin; Biopharmaceutics; Capsules; Chloramphenicol; Delayed-Action Preparations; Drug Compounding; Female; Humans; Hydrochlorothiazide; Phenacetin; Prednisone; Tablets; Tablets, Enteric-Coated; Tetracycline; Therapeutic Equivalency; Time Factors; Tolbutamide; Triamterene

1971
Effect of elevated viscosity in the upper gastrointestinal tract on drug absorption in dogs.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1998, Volume: 6, Issue:2

    Topics: Acetaminophen; Animals; Area Under Curve; Chemistry, Pharmaceutical; Cimetidine; Dogs; Female; Galactans; Gastric Emptying; Hydrochlorothiazide; Intestinal Absorption; Mannans; Mefenamic Acid; Pharmacokinetics; Plant Gums; Viscosity

1998
Separation of theophylline, caffeine and related drugs by normal-phase capillary electrochromatography.
    Electrophoresis, 1999, Volume: 20, Issue:12

    Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Electric Conductivity; Electrophoresis, Capillary; Hydrochlorothiazide; Molecular Structure; Niacin; Phenylbutazone; Theobromine; Theophylline

1999
Validation of tablet dissolution method by high-performance liquid chromatography.
    Drug development and industrial pharmacy, 2000, Volume: 26, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Chromatography, High Pressure Liquid; Diuretics; Filtration; Hydrochlorothiazide; Reproducibility of Results; Sensitivity and Specificity; Sodium Chloride Symporter Inhibitors; Solubility; Tablets

2000
Introduction to monitoring. What is what you prescribed actually doing?
    Australian family physician, 2003, Volume: 32, Issue:10

    Topics: Acetaminophen; Aged; Aspirin; Australia; Celecoxib; Drug Interactions; Drug Therapy, Combination; Family Practice; Female; Fosinopril; Humans; Hydrochlorothiazide; Hypertension; Monitoring, Physiologic; Osteoarthritis, Knee; Pyrazoles; Risk Assessment; Sensitivity and Specificity; Stroke; Sulfonamides

2003
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets.
    Drug development and industrial pharmacy, 2007, Volume: 33, Issue:9

    Topics: Acetaminophen; Caffeine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Excipients; Hydrochlorothiazide; Hypromellose Derivatives; Ketoprofen; Methylcellulose; Metoprolol; Molecular Weight; Particle Size; Solubility; Tablets; Theophylline; Viscosity

2007
Use of addition calibration technique for determination of acetaminophen and hydrochlorothiazide in human urine by high-performance liquid chromatography.
    Journal of chromatographic science, 2008, Volume: 46, Issue:9

    Topics: Acetaminophen; Calibration; Chromatography, High Pressure Liquid; Humans; Hydrochlorothiazide

2008
Multi-residue method for trace level determination of pharmaceuticals in solid samples using pressurized liquid extraction followed by liquid chromatography/quadrupole-linear ion trap mass spectrometry.
    Talanta, 2009, Nov-15, Volume: 80, Issue:1

    Topics: Acetaminophen; Atorvastatin; Chromatography, Liquid; Diclofenac; Geologic Sediments; Heptanoic Acids; Hot Temperature; Hydrochlorothiazide; Ibuprofen; Pharmaceutical Preparations; Pyrroles; Reference Standards; Reproducibility of Results; Rivers; Sewage; Solid Phase Extraction; Tandem Mass Spectrometry

2009
Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization.
    Drug development and industrial pharmacy, 2011, Volume: 37, Issue:4

    Topics: Acetaminophen; Chemistry, Pharmaceutical; Furosemide; Hydrochlorothiazide; Particle Size; Solubility; Technology, Pharmaceutical; Tensile Strength; Theophylline

2011
A novel pure component contribution algorithm (PCCA) for extracting components' contribution from severely overlapped signals; an application to UV-spectrophotometric data.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015, Volume: 151

    Topics: Acetaminophen; Algorithms; Amiloride; Atenolol; Capsules; Hydrochlorothiazide; Ibuprofen; Spectrophotometry, Ultraviolet; Tablets

2015
Development and validation of multivariate calibration methods for simultaneous estimation of Paracetamol, Enalapril maleate and hydrochlorothiazide in pharmaceutical dosage form.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2017, Jan-15, Volume: 171

    Topics: Acetaminophen; Calibration; Chromatography, High Pressure Liquid; Dosage Forms; Enalapril; Hydrochlorothiazide; Least-Squares Analysis; Linear Models; Multivariate Analysis; Reference Standards; Reproducibility of Results; Spectrum Analysis

2017
Amplified nanostructure electrochemical sensor for simultaneous determination of captopril, acetaminophen, tyrosine and hydrochlorothiazide.
    Materials science & engineering. C, Materials for biological applications, 2017, Apr-01, Volume: 73

    Topics: Acetaminophen; Captopril; Electrochemical Techniques; Humans; Hydrochlorothiazide; Nanostructures; Nanotubes, Carbon; Nickel; Oxidation-Reduction; Tyrosine; X-Ray Diffraction

2017
Downstream processing from melt granulation towards tablets: In-depth analysis of a continuous twin-screw melt granulation process using polymeric binders.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 124

    Topics: Acetaminophen; Compressive Strength; Drug Compounding; Excipients; Hydrochlorothiazide; Models, Statistical; Multivariate Analysis; Phase Transition; Polymers; Porosity; Powders; Principal Component Analysis; Quality Control; Tablets; Technology, Pharmaceutical; Tensile Strength; Transition Temperature

2018
Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally disintegrating tablets.
    International journal of pharmaceutics, 2020, Oct-15, Volume: 588

    Topics: Acetaminophen; Administration, Oral; Drug Compounding; Excipients; Freeze Drying; Hydrochlorothiazide; Mannitol; Polysaccharides, Bacterial; Polyvinyl Alcohol; Polyvinyls; Solubility; Tablets; Viscosity

2020
The Precision and Accuracy of 3D Printing of Tablets by Fused Deposition Modelling.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:10

    Topics: Acetaminophen; Drug Liberation; Humans; Hydrochlorothiazide; Polyvinyl Alcohol; Printing, Three-Dimensional; Tablets; Technology, Pharmaceutical

2022