acetaminophen and fomepizole

acetaminophen has been researched along with fomepizole in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.70)	18.7374
1990's	2 (5.41)	18.2507
2000's	5 (13.51)	29.6817
2010's	5 (13.51)	24.3611
2020's	24 (64.86)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Burk, RF; Hill, KE; Hunt, RW; Martin, AE	1
Lee, CA; Nelson, SD; Pearson, PG; Slattery, JT; Thummel, KE	1
Baevsky, RH; Brennan, RJ; DelVecchio, JA; Lefevre, R; Mankes, RF; Raccio-Robak, N; Zink, BJ	1
Hazai, E; Monostory, K; Vereczkey, L	1
Acar, HV; Cankir, Z; Cermik, H; Cinan, U; Danaci, M; Küçükardali, Y; Nalbant, S; Ozkan, S; Top, C	1
Liebelt, EL; White, ML	1
Braszko, JJ; Holownia, A; Jablonski, J; Mroz, R; Sitko, E; Skiepko, A	1
Akahori, F	1
Heard, K; Yip, L	1
Akakpo, JY; Jaeschke, H; Kandel, SE; Kumer, SC; Ni, HM; Ramachandran, A; Rumack, BH	1
Akakpo, JY; Ding, WX; Duan, L; Freudenthal, BD; Jaeschke, H; Jaeschke, MW; Ramachandran, A; Rumack, BH; Schaich, MA	1
Akakpo, JY; Curry, SC; Fisher, ES; Gerkin, RD; Jaeschke, H; Kang, AM; Padilla-Jones, A; Rumack, BH	1
Beuhler, MC; Shah, KR	1
Hays, WB; Patel, KH; Woolum, JA	1
Beuhler, MC; Dulaney, A; Fox, C; Geib, AJ; Kerns Ii, W; Kopec, K; Murphy, C; Shah, KR	1
Bateman, DN; Dear, JW; Eddleston, M; Vale, JA	2
Freeman, WE; Mullins, ME; Yeager, LH	1
Beuhler, MC; Dulaney, A; Fox, C; Geib, AJ; Kerns, W; Kopec, K; Murphy, C; Shah, KR	1
Akakpo, JY; Jaeschke, H; Ramachandran, A	1
Akakpo, JY; Curry, SC; Jaeschke, H; Orhan, H; Ramachandran, A; Rumack, BH	1
Akakpo, JY; Curry, SC; Jaeschke, H; Jaeschke, MW; Ramachandran, A; Rumack, BH	1
Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ	2
Mehrpour, O; Nakhaee, S; Pourbagher-Shahri, AM; Schimmel, J; Shirazi, FM	1
Lebin, JA; Mudan, A	1
Hoffman, RS; Mahonski, S; Mohan, S	1
Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH	1
Dart, RC; Kaiser, SK	1
Berg, SE; Filip, AB; Mullins, ME; Schwarz, ES	1
Akakpo, JY; Artigues, A; Etemadi, Y; Jaeschke, H; Jaeschke, MW; Midey, A; Olivos, H; Ramachandran, A; Shrestha, B; Toerber, S	1
Dear, JW	1
Filip, AB; Mullins, ME	1
Hameed, M; Hunter, N; Jamal, H; Kusnik, A; Mostafa, MR; Sharma, R	1
Bateman, DN; Dear, JW	1

Reviews

8 review(s) available for acetaminophen and fomepizole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Update on antidotes for pediatric poisoning. Pediatric emergency care, 2006, Volume: 22, Issue:11 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Antidotes; Antivenins; Child; Child, Preschool; Cholinergic Antagonists; Cholinesterase Inhibitors; Crotalid Venoms; Emergencies; Ethylene Glycol; Female; Fomepizole; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fragments; Infant; Infusions, Intravenous; Injections, Intramuscular; Male; Methanol; Poisoning; Practice Guidelines as Topic; Pyrazoles; Snake Bites; Syringes	2006
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review. Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12 Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; Fomepizole; Humans; Mitochondria; Pyridoxal Phosphate	2020
Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert opinion on drug metabolism & toxicology, 2020, Volume: 16, Issue:11 Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Edetic Acid; Fomepizole; Hepatocytes; Humans; Liver Failure, Acute; Pyridoxal Phosphate	2020
Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. Toxicology letters, 2022, Feb-01, Volume: 355 Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Fomepizole; Humans	2022
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of toxicology, 2022, Volume: 96, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Mice	2022
The Roles of Antidotes in Emergency Situations. Emergency medicine clinics of North America, 2022, Volume: 40, Issue:2 Topics: Acetaminophen; Acetylcysteine; Antidotes; Fomepizole; Humans; Methylene Blue	2022
Fomepizole as an emerging adjunct in treating severe acetaminophen toxicity: a case report and a brief review. Journal of gastrointestinal and liver diseases : JGLD, 2022, 12-17, Volume: 31, Issue:4 Topics: Acetaminophen; Fomepizole; Humans; Pyrazoles	2022

Trials

1 trial(s) available for acetaminophen and fomepizole

Article	Year
The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2020, Volume: 16, Issue:2 Topics: Acetaminophen; Activation, Metabolic; Administration, Oral; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Interactions; Female; Fomepizole; Humans; Infusions, Intravenous; Male; Middle Aged; Oxidation-Reduction	2020

Article

Year

The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers.

Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2020, Volume: 16, Issue:2

Topics: Acetaminophen; Activation, Metabolic; Administration, Oral; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Interactions; Female; Fomepizole; Humans; Infusions, Intravenous; Male; Middle Aged; Oxidation-Reduction

2020

Other Studies

28 other study(ies) available for acetaminophen and fomepizole

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it. Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Glutathione; Isoniazid; Liver; Male; Phenobarbital; Pyrazoles; Rats; Rats, Inbred F344	1990
Effect of ethanol on hepatotoxicity of acetaminophen in mice and on reactive metabolite formation by mouse and human liver microsomes. Toxicology and applied pharmacology, 1989, Sep-15, Volume: 100, Issue:3 Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme Inhibitors; Ethanol; Fomepizole; Humans; In Vitro Techniques; Male; Mice; Microsomes, Liver; Pyrazoles	1989
4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat. Annals of emergency medicine, 1994, Volume: 23, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Fomepizole; Liver; Male; Necrosis; Pyrazoles; Rats; Rats, Sprague-Dawley	1994
Reduction of toxic metabolite formation of acetaminophen. Biochemical and biophysical research communications, 2002, Mar-08, Volume: 291, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Benzoquinones; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Enzyme Inhibitors; Fomepizole; Humans; Imines; Microsomes, Liver; Pyrazoles	2002
Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats. Current medical research and opinion, 2002, Volume: 18, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alcohol Dehydrogenase; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Therapy, Combination; Fomepizole; Liver; Male; Necrosis; Pyrazoles; Rats; Rats, Wistar; Transaminases	2002
Ruthenium red protects HepG2 cells overexpressing CYP2E1 against acetaminophen cytotoxicity. Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 379, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Calcium; Cell Survival; Coloring Agents; Cytochrome P-450 CYP2E1; Fomepizole; Humans; Microsomes, Liver; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Oxidative Stress; Pyrazoles; Pyrrolidines; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Superoxide Dismutase; Transfection; Tumor Cells, Cultured	2009
[Application in veterinary and human clinical toxicology]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2009, Volume: 22, Issue:4 Topics: Acetaminophen; Aflatoxins; Animals; Biphenyl Compounds; Cat Diseases; Cats; Chickens; Ethylene Glycol; Fomepizole; Food Contamination; Fumonisins; Humans; Ivermectin; Mercury Poisoning, Nervous System; Plant Oils; Poisoning; Poultry Diseases; Pyrazoles; Rice Bran Oil; Species Specificity; Toxicology; Veterinary Medicine	2009
Potential adjunct treatment for high-risk acetaminophen overdose. Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:5 Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors; Drug Overdose; Fomepizole; Humans; Imines; Liver; Pyrazoles	2016
4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Human & experimental toxicology, 2018, Volume: 37, Issue:12 Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Fomepizole; Glutathione; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice, Inbred C57BL; Protective Agents	2018
Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 07-01, Volume: 170, Issue:1 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Time-to-Treatment	2019
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity. The American journal of emergency medicine, 2020, Volume: 38, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans; Male; Treatment Outcome	2020
Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose. The American journal of emergency medicine, 2020, Volume: 38, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Fomepizole; Free Radical Scavengers; Humans; Male; Middle Aged; Renal Dialysis	2020
Fomepizole as an adjunctive treatment in severe acetaminophen ingestions: a case series. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug Therapy, Combination; Female; Fomepizole; Humans; Middle Aged; Treatment Outcome	2021
Comment on Fomepizole as an adjunctive treatment in severe acetaminophen ingestions. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:1 Topics: Acetaminophen; Antidotes; Drug Overdose; Eating; Fomepizole; Humans	2021
Authors' reply to Comment on Fomepizole as an adjunctive treatment in severe acetaminophen ingestions. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:1 Topics: Acetaminophen; Antidotes; Drug Overdose; Eating; Fomepizole; Humans	2021
4-methylpyrazole protects against acetaminophen-induced acute kidney injury. Toxicology and applied pharmacology, 2020, 12-15, Volume: 409 Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Female; Fomepizole; Glutathione; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Middle Aged; Prospective Studies; Protective Agents; Young Adult	2020
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole. Archives of toxicology, 2021, Volume: 95, Issue:10 Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Male; Mice; Mice, Inbred C57BL; Time Factors	2021
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:4 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans	2022
Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans	2022
Reply to Comments on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans	2022
Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans	2022
Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans	2022
Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015-2020. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:9 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Databases, Factual; Fomepizole; Humans	2022
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole. Journal of the American Society for Mass Spectrometry, 2022, Nov-02, Volume: 33, Issue:11 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Humans; Liver; Mice; Mice, Inbred C57BL; Necrosis; Spectrometry, Mass, Electrospray Ionization	2022
Fomepizole should not be used more liberally in paracetamol overdose. British journal of clinical pharmacology, 2023, Volume: 89, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COVID-19; Drug Overdose; Fomepizole; Humans	2023
Fomepizole should be used more liberally in paracetamol overdose. British journal of clinical pharmacology, 2023, Volume: 89, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fomepizole; Humans	2023
Developing new antidotes for poisons with existing effective treatments: a case study of fomepizole in paracetamol poisoning. Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:8 Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Fomepizole; Humans; Mice; Poisons	2023