acetaminophen has been researched along with cysteine in 178 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (38.76) | 18.7374 |
| 1990's | 33 (18.54) | 18.2507 |
| 2000's | 29 (16.29) | 29.6817 |
| 2010's | 37 (20.79) | 24.3611 |
| 2020's | 10 (5.62) | 2.80 |
| Authors | Studies |
|---|---|
| Goon, DJ; Nagasawa, HT; Yuzon, DL; Zera, RT | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Legros, J | 1 |
| Harvey, FD; Levitt, TE | 1 |
| Black, M | 2 |
| Adriaenssens, PI; Prescott, LF | 1 |
| Moldéus, P | 1 |
| Levy, G; Slattery, JT | 1 |
| Hart, FE; Willson, RA | 1 |
| Buckpitt, AR; Franklin, RB; Mitchell, JR; Nelson, SD; Rollins, DE | 1 |
| Davis, M; Harrison, NG; Simmons, CJ; Williams, R | 1 |
| Houston, JB; Levy, G | 1 |
| Andrews, RS; Bond, CC; Burnett, J; Saunders, A; Watson, K | 1 |
| Davis, M; Labadarios, D; Williams, RS | 1 |
| Day, PA; McLean, AE | 1 |
| Hynie, I; Thomas, BH; Wong, LT; Zeitz, W | 1 |
| Alván, G; Evaldsson-Carlén, U; Mellström, B | 1 |
| Bertolotti, M; Castellana, CN; Ferrari, A; Pini, LA; Sternieri, E; Trenti, T | 1 |
| Dalhoff, K; Poulsen, HE | 2 |
| Emery, P; Waring, RH | 1 |
| Butterworth, M; Cohen, GM; Smith, LL; Upshall, DG | 1 |
| Charyulu, RL; Nagasawa, HT; Roberts, JC; Zera, RT | 1 |
| Chen, TS; Lang, CA; Richie, JP | 1 |
| Fullerton, FR; Hathcock, JN; Poirier, LA; Reicks, MM; Whittaker, P | 1 |
| Ivey, KJ; Raza, A; Razandi, M; Romano, M; Szabo, S | 1 |
| Critchley, JA; Leung, NW | 1 |
| McLean, AE; Nazareth, WM; Sethi, JK | 1 |
| Klaassen, CD; Madhu, C | 1 |
| Benson, RW; Hinson, JA; Pumford, NR; Roberts, DW | 1 |
| Chen, NQ; Goon, DJ; Holtzman, JL; Liu, YX; Prasad, JS | 1 |
| Furukawa, T; Palacin, M; Perez, C; Viña, J; Viña, JR | 1 |
| Burgunder, JM; Lauterburg, BH; Varriale, A | 1 |
| Black, M; Lasker, JM; Lieber, CS; Raucy, JL | 1 |
| Hathcock, JN; Reicks, M | 1 |
| Nelson, SD; Rashed, MS | 1 |
| Gemborys, MW; Hoefle, D; Hook, JB; Mudge, GH; Newton, JF | 1 |
| Benson, RW; Hinson, JA; Potter, DW; Pumford, NR; Roberts, DW; Rowland, KL | 1 |
| Armstrong, GR; Beales, D; McLean, AE | 1 |
| Moldéus, P; Norbeck, K; Ross, D | 1 |
| Degott, C; Descatoire, V; Foliot, A; Geneve, J; Larrey, D; Letteron, P; Pessayre, D; Tinel, M | 1 |
| Lauterburg, BH; Velez, ME | 1 |
| Baille, TA; Calleman, CJ; Pascoe, GA | 1 |
| Calvert, RJ; Hathcock, JN; Reicks, M | 1 |
| Yeung, JH | 1 |
| Baillie, TA; Hoffmann, KJ | 1 |
| Critchley, JA; Gregson, CA; Nimmo, GR; Prescott, LF; Woolhouse, NM | 1 |
| Benson, RW; Hinson, JA; Potter, DW; Pumford, NR; Roberts, DW | 1 |
| Lauterburg, BH; Mitchell, JR | 1 |
| Fricke, RF; Goon, DJ; Nagasawa, HT; Roberts, JC; Zera, RT | 1 |
| Anderson, ME; Hwang, O; Meister, A | 1 |
| To, EC; Wells, PG | 1 |
| Jayasinghe, KS; Read, AE; Roberts, CJ | 1 |
| Allen, JM; Andrews, RS; Warrander, A | 1 |
| Atkins, LM; Fody, EP; Gale, GR; Smith, AB; Walker, EM | 1 |
| Ecobichon, DJ; Hidvegi, S | 1 |
| Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Carney, MM; Nikiforov, V; Shih, VE | 1 |
| Axworthy, DB; Baillie, TA; Hoffmann, KJ; Streeter, AJ | 1 |
| Bracken, WM; Dudley, RE; Goering, PL; Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Davis, M; Harrison, N; Simmons, CJ; Williams, R | 1 |
| Schütt, A; Siegers, CP; Strubelt, O | 1 |
| Brodie, BB; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ | 1 |
| Christie, WH; Dinsmore, SR; Katz, S; Mrochek, JE | 1 |
| Levy, G | 1 |
| Levy, G; Yamada, H | 1 |
| Curzio, M; Flaccavento, C; Negro, F; Paradisi, L; Torrielli, MV | 1 |
| Hammarström, S; Ormstad, K; Orning, L; Uehara, N | 1 |
| Breckenridge, AM; Park, BK; Yeung, JH | 1 |
| Linden, CH; Rumack, BH | 1 |
| Thomas, P; Wofford, HW | 1 |
| Birkett, DJ; Drew, R; Miners, JO | 1 |
| Fearon, Z; Guerrero Munoz, F | 1 |
| Delaforge, M; Hall, DE; Ioannides, C; Mulder, DE; Parke, DV; Spickett, J; Steele, CM | 1 |
| Estrela, JM; Sáez, GT; Such, L; Viña, J | 1 |
| Baillie, TA; Dahlin, DC; Nelson, SD; Streeter, AJ | 1 |
| Goon, DJ; Muldoon, WP; Nagasawa, HT; Zera, RT | 1 |
| Baars, AJ; Glazenburg, EJ; Jekel-Halsema, IM; Mulder, GJ; Scholtens, E | 1 |
| Boettcher, B; Meister, A; Williamson, JM | 1 |
| Balali-Mood, M; Critchley, JA; Pentland, B; Prescott, LF | 1 |
| Calder, I; Hart, S; Ross, B; Tange, J | 1 |
| Corcoran, GB; Horning, EC; Mitchell, JR; Vaishnav, YN | 1 |
| Gillette, JR | 1 |
| Davies, MH; Elias, E; Ngong, JM; Pean, A; Vickers, CR; Waring, RH | 1 |
| Critchley, JA; Lau, GS | 1 |
| Murray-Lyon, IM; Thuluvath, P; Tredger, JM; Williams, R | 1 |
| Johansson, L; Lindvall, S; Rydell, G; Svensson, BE; Ulff, B | 1 |
| Martin, U; Prescott, LF; Temple, RM; Winney, RJ | 1 |
| Hatamori, N; Hayashi, Y; Hirohata, T; Kasuga, M; Mimoto, H; Mizoguchi, Y; Morita, S; Nakaoka, T; Yoshida, H; Yun, S | 1 |
| Benzick, AE; Gomez, MR; Heird, WC; Rogers, LK; Smith, CV | 1 |
| Esteban, A; Graells, ML; Mayole, MJ; Pérez-Mateo, M; Satorres, J | 1 |
| Cohen, JF; Holleschau, AM; Nagasawa, HT; Rathbun, WB | 1 |
| Holleschau, AM; Killen, CE; Nagasawa, HT; Rathbun, WB | 1 |
| Gibson, JD; Halmes, NC; Hinson, JA; Pumford, NR; Roberts, DW | 1 |
| Hinson, JA; Matthews, AM; Pumford, NR; Roberts, DW | 1 |
| Erickson, RR; Holtzman, JL; Zhou, L | 1 |
| Erickson, RR; Hardwick, JP; Holtzman, JL; Park, SS; Wrighton, SA; Zhou, L | 1 |
| Cohen, JF; Nagasawa, HT; Rathbun, WB; Shoeman, DW | 1 |
| Rommelspacher, H; Włodek, L | 1 |
| Franklin, MR; Lamb, JG; Phaneuf, HL; Roberts, JC; Szakacs, JG; Zera, RT | 1 |
| Itakura, Y; Kasuga, S; Matsura, T; Sumioka, I; Yamada, K | 1 |
| Chen, W; Gartner, C; Hunter, A; Nelson, SD; Shockcor, JP; Tonge, R | 1 |
| Ajami, AM; Fukagawa, NK; Hercules, E | 1 |
| Chen, TS; Lang, CA; Nagasawa, HT; Richie, JP | 1 |
| Chen, TS; Ray, MB; Srinivasan, C; Williams, WM | 1 |
| Chen, TS; Song, H | 1 |
| Chen, TS; Nagasawa, HT; Srinivasan, C; Williams, WM | 1 |
| Beck, MJ; Harris, C; Lightle, RL; McLellan, C; Philbert, MA | 1 |
| Matsura, T; Sumioka, I; Yamada, K | 1 |
| Coop, L; Hendrickson, HP; Hinson, JA; James, LP; Mayeux, PR; McCullough, SS; Muldrew, KL | 1 |
| DeMaster, EG; Nagasawa, HT; Shirota, FN; Shoeman, DW | 1 |
| Berkeley, LI; Cohen, JF; Crankshaw, DL; Nagasawa, HT; Shirota, FN | 2 |
| Bruno, MK; Cohen, SD; Hennig, GE; Horton, RA; Roberts, JC; Stern, ST | 1 |
| Bruno, MK; Cohen, SD; Hill, DW; Horton, RA; Roberts, JC; Stern, ST | 1 |
| Christopher, MM; Hill, AS; O'Neill, SL; Rogers, QR | 1 |
| Anderson, PJ; Critchley, JA; Critchley, LA; Tomlinson, B | 1 |
| Cohen, SD; Dominick, PK; Roberts, JC; Slitt, AM | 1 |
| Hsu, CC; Liao, TS; Lin, CC; Yin, MC | 1 |
| Chantharaksri, U; Fucharoen, P; Fucharoen, S; Howard, TA; Morales, NP; Sanvarinda, Y; Sirankapracha, P; Tankanitlert, J; Temsakulphong, A; Ware, RE | 1 |
| Alonso, EM; Davern, TJ; Hinson, JA; Hynan, LS; James, LP; Lee, WM; Squires, RH | 1 |
| Bond, GR | 2 |
| Liebler, DC; Liu, Q; Shin, NY; Stamer, SL | 1 |
| Commandeur, JN; Damsten, MC; Fidder, A; Hulst, AG; Noort, D; Touw, D; Vermeulen, NP | 1 |
| Atkuri, KR; Herzenberg, LA; Mantovani, JJ | 1 |
| Boos, J; Hempel, G; Koling, S; Lanvers, C; Würthwein, G | 1 |
| Boerma, JS; Dowdall, SM; Goldring, CE; Hamlett, J; Jenkins, RE; Kitteringham, NR; Lane, CS; Park, BK; Vermeulen, NP | 1 |
| Hickling, J; Kumara De Silva, R; Medlicott, NJ; Reith, D; Yang, L; Zacharias, M | 1 |
| Cheng, J; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X | 1 |
| Kim, SJ; Kim, SY; Kim, YC; Kwon, DY; Lee, MY | 1 |
| Jones, DP; Mannery, YO; Park, Y; Ziegler, TR | 1 |
| Jaeschke, H; McGill, MR; Murray, GJ; Ramachandran, A; Rollins, DE; Yan, HM | 1 |
| Claridge, LC | 1 |
| Dart, RC; Green, JL; Heard, KJ; James, LP; Judge, BS; Rhyee, S; Zolot, L | 1 |
| Boerma, JS; Commandeur, JN; Vermeulen, NP | 1 |
| Agarwal, R; Hennings, L; Hinson, JA; James, LP; Letzig, LG; MacMillan-Crow, LA; McCullough, S; Rafferty, TM | 1 |
| Cheng, Y; Ding, Y; Li, L; Lu, Y; Xu, W; Zhang, F | 1 |
| Al-Abed, Y; Andersson, U; Antoine, DJ; Bianchi, ME; Erlandsson-Harris, H; Lundbäck, P; Ottosson, L; Tracey, KJ; Venereau, E; Yang, H | 1 |
| Atta, NF; El-Ads, EH; Galal, A | 1 |
| Abdel-Rahman, SM; Chiew, A; Day, P; Graudins, A; James, LP; Letzig, L; Roberts, D | 1 |
| Emmett, M | 1 |
| Bajt, ML; Jaeschke, H; Lebofsky, M; McGill, MR; Williams, CD | 1 |
| Bikin, DS; Curry, SC; Gerkin, RD; O'Connor, AD; Padilla-Jones, A; Rollins, DE; Ruha, AM; Slawson, MH; Wilkins, DG | 1 |
| Dardevet, D; Joly, C; Mast, C; Papet, I; Remond, D; Savary-Auzeloux, I | 1 |
| Dart, RC; Frey, SM; Gorodetsky, RM; Green, JL; Heard, KJ; Wiegand, TJ; Wilkins, DG | 1 |
| Giraldo, P; Mizrahi, F; O'Malley, GF; O'Malley, RN; Rollins, D; Wilkins, D | 1 |
| Harrison, C; Regina, A; Steger, C; Su, M | 1 |
| O'Malley, GF | 1 |
| Büter, L; Faber, H; Karst, U; Vogel, M; Wigger, T | 1 |
| Harrison, EM; Homer, N; Hughes, MJ; Jin, Y; Wigmore, SJ | 1 |
| Anilkumar, N; Brandes, RP; Brewer, AC; Burr, S; Caldwell, A; Dew, T; Dong, X; Halket, J; Hughes, RD; Martin, D; Mistry, RK; Murray, TV; Quaglia, A; Sawyer, GJ; Schröder, K; Shah, AM; Sherwood, R | 1 |
| Anderson, V; Bucher-Bartelson, B; Dart, RC; Green, JL; Heard, K | 1 |
| Boerma, D; Huisman, FW; Knibbe, CAJ; Peeters, MYM; Välitalo, PAJ; van den Anker, JN; van Dongen, EPA; van Ramshorst, B; van Rongen, A | 1 |
| Fujii, J; Homma, T; Kang, ES; Kurahashi, T; Lee, J; Miyata, S; Nabeshima, A; Nakayama, T; Saito, Y; Yamada, K; Yamada, S | 1 |
| Anderson, V; Dart, RC; Green, JL; Heard, K; Kile, D; Lavonas, EJ | 1 |
| Fujii, J; Homma, T; Kang, ES; Kobayashi, S; Kurahashi, T; Lee, J; Miyata, S; Nabeshima, A; Sato, H; Seo, HG; Yamada, S | 1 |
| Allegaert, K; Flint, RB; Knibbe, CAJ; Roofthooft, DW; Simons, SHP; Tibboel, D; van den Anker, JN; van Dijk, M; van Lingen, RA; van Rongen, A | 1 |
| de la Roche, J; Eberhardt, EM; Eberhardt, MJ; Echtermeyer, F; Herzog, C; Leffler, A; Risser, L; Schillers, F | 1 |
| Athanasekou, C; Rekka, EA; Theodosis-Nobelos, P | 1 |
| Centeno, D; Dardevet, D; Mast, C; Migné, C; Papet, I; Pourpe, C; Rémond, D; Savary-Auzeloux, I; Voyard, G | 1 |
| Dardevet, D; Mast, C; Papet, I | 1 |
| Dennis, K; Ding, WX; Li, J; Li, T; Matye, D; Wang, Y; Zhang, Y | 1 |
| Chen, C; Guo, H; Hu, K; Kang, D; Li, H; Li, X; Liang, Y; Shen, B; Shen, J; Wang, G; Xie, L; Xu, Y; Yin, X; Zhu, Z | 1 |
| Kubo, T; Lee, SH; Oe, T; Ozawa, M | 1 |
| Cheng, Y; Chowdhury, A; Jia, Z; Lu, J; Song, J; Sun, Y; Teng, T; Wang, H; Yin, X; Zhang, R; Zhu, Y | 1 |
| DU, Y; Liu, XF; Lu, YH; Tan, L; Wang, GJ; Wang, YX; Wu, X; Yang, FX; Zhang, JW; Zhou, F | 1 |
| De Cock, P; De Paepe, P; Delahaye, L; Dhont, E; Stove, CP | 1 |
| Bilos, A; Koenderink, JB; Russel, FGM; van den Heuvel, JJMW; Vermeulen, NPE; Vredenburg, G | 1 |
| Cendejas Hernandez, J; Jones, JP; Konsoula, Z; Parker, W; Poulton, J; Smith, C; Suda, N | 1 |
| Chen, N; Chu, S; Cui, L; Gao, Y; He, H; Li, J; Mo, S; Sun, X; Wang, H; Zheng, J; Zhou, X | 1 |
| Bae, JE; Jung, YS; Kim, SH; Kwon, D; Lee, YH; Son, SW | 1 |
| Averous, J; Bruhat, A; Carraro, V; Combaret, L; Coudy-Gandilhon, C; Fafournoux, P; Jousse, C; Maurin, AC; Papet, I; Parry, L; Voyard, G | 1 |
| Blair, IA; Gillespie, KP; Mesaros, C; Pirnie, R; Weng, L | 1 |
| Ji, X; Liu, J; Lu, X; Tao, Y; Wang, J; Wang, N; Zhang, J; Zhao, W | 1 |
| Islam, A; Kahyo, T; Mamun, MA; Nabi, MM; Oyama, S; Rahman, MM; Sakamoto, T; Sato, T; Setou, M; Takahashi, Y | 1 |
| Capek, J; Cesla, P; Handl, J; Kubat, M; Malinak, D; Musilek, K; Nyvltova, P; Rousar, T; Rousarova, E; Smid, L; Vanova, J | 1 |
10 review(s) available for acetaminophen and cysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Hepatotoxicity: pathogenesis and therapeutic intervention.
Topics: Acetaminophen; Anabolic Agents; Androgens; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Erythromycin; Estrogens; Halothane; Humans; Isoniazid; Liver; Nitrofurantoin; Rifampin | 1979 |
Management of early inflammatory arthritis. Genetic factors predicting persistent disease: the role of defective enzyme systems.
Topics: Acetaminophen; Arthritis, Rheumatoid; Carbocysteine; Cysteine; Forecasting; Humans; Inactivation, Metabolic; Methylation; Methyltransferases; Oxidation-Reduction; Sulfates | 1992 |
Drug biotransformation interactions in man: nonnarcotic analgesics.
Topics: Acetaminophen; Adult; Analgesics; Benzoates; Biotransformation; Cysteine; Drug Synergism; Ethanol; Glucuronates; Glycine; Humans; Kinetics; Male; Metabolism; Salicylamides; Salicylates; Sodium Salicylate; Sulfuric Acids | 1971 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Cysteine; Dose-Response Relationship, Drug; Glutathione; History, 20th Century; Humans; Kinetics; Liver Diseases; Prognosis; Prothrombin Time; Time Factors | 1984 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Glutathione; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Methionine | 1980 |
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Controlled Clinical Trials as Topic; Cysteine; Cystic Fibrosis; Free Radical Scavengers; Glutathione; HIV Infections; Humans; Prodrugs; Quality of Life | 2007 |
Acetaminophen protein adducts: a review.
Topics: Acetaminophen; Animals; Cysteine; Humans; Liver; Protein Binding; Radioligand Assay | 2009 |
Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Cysteine; Energy Metabolism; Glutathione; Humans; Poisoning; Prognosis; Pyrrolidonecarboxylic Acid; Substrate Cycling | 2014 |
Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case.
Topics: Acetaminophen; Aged; Amino Acids, Sulfur; Animals; Chronic Pain; Cysteine; Dietary Proteins; Frail Elderly; Glutathione; Humans; Inactivation, Metabolic; Liver; Muscle Proteins; Muscle, Skeletal; Nutritional Requirements; Sarcopenia; Sulfates | 2018 |
6 trial(s) available for acetaminophen and cysteine
| Article | Year |
|---|---|
Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Antineoplastic Agents; Benzoquinones; Child; Child, Preschool; Cysteine; Drug Administration Schedule; Drug Interactions; Humans; Imines; Infant; Neoplasms; Oxidation-Reduction | 2007 |
Oxidation of plasma cysteine/cystine and GSH/GSSG redox potentials by acetaminophen and sulfur amino acid insufficiency in humans.
Topics: Acetaminophen; Adolescent; Adult; Amino Acids, Sulfur; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Cross-Over Studies; Cysteine; Cystine; Diet; Double-Blind Method; Eating; Female; Glutathione; Humans; Male; Oxidation-Reduction; Young Adult | 2010 |
Acetaminophen-cysteine adducts during therapeutic dosing and following overdose.
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Alcoholism; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Cysteine; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Middle Aged; Young Adult | 2011 |
Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Cross-Over Studies; Cysteine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Fasting; Female; Humans; Male; Protein Binding; Proteins; Young Adult | 2013 |
Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Biomarkers; Cysteine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Young Adult | 2016 |
Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Area Under Curve; Biotransformation; Cysteine; Female; Gestational Age; Glucuronides; Glutathione; Humans; Infant, Extremely Premature; Infant, Newborn; Infusions, Intravenous; Male; Netherlands; Sulfates | 2017 |
162 other study(ies) available for acetaminophen and cysteine
| Article | Year |
|---|---|
Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cysteine; Magnetic Resonance Spectroscopy; Mice; Thiazoles | 1982 |
Animal studies--a theoretical basis for treatment.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Animals; Antidotes; Cysteine; Disease Models, Animal; Female; Male; Methionine; Mice; Nicotinic Acids; Sulfhydryl Compounds | 1976 |
Experimental evaluation of paracetamol antidotes.
Topics: Acetaminophen; Animals; Antidotes; Bile; Cysteamine; Cysteine; Ditiocarb; Glutathione; Imidazoles; In Vitro Techniques; Liver; Methionine; Mice; Rats | 1976 |
High performance liquid chromatographic estimation of paracetamol metabolites in plasma.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Cysteine; Glucuronates; Humans; Sulfates; Time Factors | 1978 |
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glucuronates; Glutathione; In Vitro Techniques; Liver; Male; Mice; Phenobarbital; Rats; Sulfates; Time Factors | 1978 |
Acetaminophen kinetics in acutely poisoned patients.
Topics: Acetaminophen; Acetylcysteine; Adult; Computers; Cysteine; Glucuronates; Humans; Kinetics; Models, Biological; Oxidation-Reduction; Sulfates | 1979 |
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury.
Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Induction; Glutathione; In Vitro Techniques; Liver Diseases; Male; Methionine; Microsomes, Liver; Phenobarbital; Rats; Solvents | 1977 |
Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.
Topics: Acetaminophen; Acetylcysteine; Cell-Free System; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Microsomes, Liver | 1977 |
Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glucuronates; Humans; Liver Diseases; Male; Suicide; Sulfates | 1976 |
Drug biotransformation interactions in man VI: acetaminophen and ascorbic acid.
Topics: Acetaminophen; Ascorbic Acid; Biotransformation; Cysteine; Depression, Chemical; Drug Interactions; Half-Life; Kinetics; Sulfates | 1976 |
Isolation and identification of paracetamol metabolites.
Topics: Acetaminophen; Acetylcysteine; Cysteine; Glucuronates; Humans; Sulfates | 1976 |
Metabolism of paracetamol after therapeutic and hepatotoxic doses in man.
Topics: Acetaminophen; Acetylcysteine; Cysteine; Glucuronates; Humans; Liver; Sulfates | 1976 |
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 Enzyme System; Dietary Proteins; Drug Combinations; Fasting; Glutathione; Lethal Dose 50; Liver; Male; Methionine; Necrosis; Oils; Phenobarbital; Rats; Selenium; Yeast, Dried | 1975 |
Metabolism of 14C-ring-labelled paracetamol in humans.
Topics: Acetaminophen; Cysteine; Female; Glucuronates; Humans; Sulfhydryl Compounds; Sulfuric Acids | 1975 |
[Paracetamol poisoning--clinical picture and treatment possibilities].
Topics: Acetaminophen; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Drug Synergism; Female; Humans; Liver; Methionine; Oxazepam | 1976 |
Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma cysteine and thiol groups after reduced glutathione administration.
Topics: Acetaminophen; Cysteine; Glutathione; Humans; Substance-Related Disorders; Sulfhydryl Compounds | 1992 |
Effects of cysteine and acetaminophen on the syntheses of glutathione and adenosine 3'-phosphate 5'-phosphosulfate in isolated rat hepatocytes.
Topics: Acetaminophen; Animals; Cysteine; Female; Glutathione; Liver; Phosphoadenosine Phosphosulfate; Rats; Rats, Inbred Strains | 1992 |
Cysteine isopropylester protects against paracetamol-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 Enzyme System; Glutathione; Kidney; Liver Diseases; Lung; Male; Mice; Mice, Inbred BALB C; Spleen; Sulfhydryl Compounds | 1992 |
Protection against acetaminophen hepatotoxicity by ribose-cysteine (RibCys).
Topics: Acetaminophen; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Cysteine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Male; Mice; Prodrugs; Thiazoles; Thiazolidines | 1992 |
Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney.
Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Body Weight; Cysteine; Cystine; Dose-Response Relationship, Drug; Glutathione; Kidney; Male; Mice; Mice, Inbred C57BL; Organ Size | 1992 |
Prolonged acetaminophen ingestion by mice fed a methionine-limited diet does not affect iron-induced liver lipid peroxidation or S-adenosylmethionine.
Topics: Acetaminophen; Animals; Cysteine; Glutathione; Glutathione Peroxidase; Iron; Lipid Peroxidation; Liver; Male; Methionine; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 1992 |
Sulphydryl mediation in the protection of gastric mucosal cells in tissue culture by acetaminophen.
Topics: Acetaminophen; Cell Line; Cell Survival; Cysteine; Gastric Mucosa; Glutathione; Humans; In Vitro Techniques; Iodoacetamide; Sulfhydryl Compounds; Taurocholic Acid | 1991 |
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Cysteine; Cytochrome P-450 Enzyme System; Hepatitis B; Humans; Liver Neoplasms; Middle Aged; Oxidation-Reduction; Reference Values | 1991 |
Effect of paracetamol on mitochondrial membrane function in rat liver slices.
Topics: Acetaminophen; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Membrane; Cysteine; Intracellular Fluid; Intracellular Membranes; Liver; Male; Membrane Potentials; Mitochondria, Liver; Onium Compounds; Pyridines; Rats; Rats, Inbred Strains; Thiocyanates; Trityl Compounds | 1991 |
Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biliary Tract; Cricetinae; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; L-Iditol 2-Dehydrogenase; Liver; Male; Mesocricetus; Pregnenolone Carbonitrile | 1991 |
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Cell Membrane; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cysteine; Cytosol; Fluorescent Antibody Technique; Imines; Kinetics; Liver; Male; Mice; Microsomes, Liver; Mitochondria, Liver; Quinones | 1990 |
Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats.
Topics: Acetaminophen; Alcoholism; Animals; Benzoquinones; Cysteine; Ethanol; Imines; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains | 1990 |
Effect of oral glutathione on hepatic glutathione levels in rats and mice.
Topics: Acetaminophen; Acetylcysteine; Adenosine Triphosphate; Animals; Cysteine; Fasting; Glutathione; Liver; Maleates; Methionine; Mice; Rats; Rats, Inbred Strains | 1989 |
Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration.
Topics: Acetaminophen; Acetylcysteine; Adult; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Half-Life; Humans; Male; Sulfhydryl Compounds | 1989 |
Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2.
Topics: Acetaminophen; Amino Acid Sequence; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cricetinae; Cysteine; Cytochrome P-450 Enzyme System; Ethanol; Humans; Immunoblotting; Immunoglobulin G; Kinetics; Male; Mesocricetus; Microsomes, Liver; Molecular Sequence Data; Molecular Weight | 1989 |
Prolonged acetaminophen ingestion in mice: effects on the availability of methionine for metabolic functions.
Topics: Acetaminophen; Animals; Body Weight; Cysteine; Glutathione; Liver; Male; Methionine; Mice; Nutritive Value; Time Factors | 1989 |
Use of thermospray liquid chromatography-mass spectrometry for characterization of reactive metabolites of 3'-hydroxyacetanilide, a non-hepatotoxic regioisomer of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cysteine; Isomerism; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice | 1989 |
Metabolism and excretion of a glutathione conjugate of acetaminophen in the isolated perfused rat kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Kidney; Male; Metabolic Clearance Rate; Perfusion; Rats; Rats, Inbred F344 | 1986 |
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice.
Topics: Acetaminophen; Animals; Blood Proteins; Cysteine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Liver; Male; Mice; Protein Binding; Time Factors | 1989 |
Effect of D- or L-methionine and cysteine on the growth inhibitory effects of feeding 1% paracetamol to rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Growth; Methionine; Phenobarbital; Rats; Sulfates | 1989 |
The generation and subsequent fate of glutathionyl radicals in biological systems.
Topics: Acetaminophen; Acetylcysteine; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Glutathione Disulfide; Horseradish Peroxidase; Nitrogen; Oxygen; Phenetidine; Spin Labels | 1985 |
Effects of pregnancy on the toxicity and metabolism of acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Cysteine; Cytosol; Female; Glucuronosyltransferase; Glutathione; Glutathione Transferase; Lipid Peroxides; Liver; Mice; Microsomes, Liver; Mixed Function Oxygenases; Pregnancy; Pregnancy, Animal; Protein Binding; Sulfurtransferases | 1986 |
Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Humans; Liver; Male; Risk Factors | 1988 |
Identification of S-(2,5-dihydroxyphenyl)-cysteine and S-(2,5-dihydroxyphenyl)-N-acetyl-cysteine as urinary metabolites of acetaminophen in the mouse. Evidence for p-benzoquinone as a reactive intermediate in acetaminophen metabolism.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, High Pressure Liquid; Cysteine; Hydroquinones; Male; Mice; Mice, Inbred BALB C; Quinones | 1988 |
Effects of prolonged acetaminophen ingestion and dietary methionine on mouse liver glutathione.
Topics: Acetaminophen; Alanine Transaminase; Aniline Hydroxylase; Animals; Cysteine; Diet; Female; Glutathione; Liver; Male; Methionine; Mice; Microsomes, Liver | 1988 |
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds | 1988 |
The use of alkoxycarbonyl derivatives for the mass spectral analysis of drug-thioether metabolites. Studies with the cysteine, mercapturic acid and glutathione conjugates of acetaminophen.
Topics: Acetaminophen; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cysteine; Esters; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Mass Spectrometry | 1988 |
Inter-subject and ethnic differences in paracetamol metabolism.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Black People; Cysteine; Ethanol; Female; Ghana; Glucuronates; Humans; Kenya; Male; Scotland; Sex Characteristics; Smoking; Sulfates; White People | 1986 |
A sensitive immunochemical assay for acetaminophen-protein adducts.
Topics: Acetaminophen; Animals; Cysteine; Enzyme-Linked Immunosorbent Assay; Liver; Mathematics; Methods; Mice; Microsomes, Liver; NADP; Protein Binding; Proteins; Rabbits | 1987 |
Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man.
Topics: Acetaminophen; Animals; Cysteine; Dose-Response Relationship, Drug; Female; Glutathione; Humans; Liver; Male; Rats; Rats, Inbred Strains | 1987 |
Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cysteine; Drug Therapy; Glutathione; Liver; Methionine Sulfoximine; Mice; Prodrugs; Rats; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1987 |
Intracellular cysteine and glutathione delivery systems.
Topics: Acetaminophen; Animals; Biological Transport, Active; Cysteine; Dipeptides; Glutathione; Intracellular Fluid; Kidney; Liver; Mice; Models, Biological; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Sulfur; Thiazoles; Thiazolidines | 1986 |
Effect of diethyl ether on the bioactivation, detoxification, and hepatotoxicity of acetaminophen in vitro and in vivo.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biotransformation; Cysteine; Cytochrome P-450 Enzyme System; Drug Synergism; Ether; Ethyl Ethers; Glucuronates; Glutathione; Inactivation, Metabolic; Kinetics; Liver; Male; Mice; Sulfates | 1986 |
Is biliary excretion of paracetamol significant in man?
Topics: Acetaminophen; Adult; Bile; Cysteine; Female; Glucuronates; Humans; Male; Middle Aged | 1986 |
Incorporation of radiolabelled amino acids into the sulphur-containing metabolites of paracetamol by the hamster.
Topics: Acetaminophen; Amino Acids; Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cricetinae; Cysteine; Male; Mesocricetus; Methionine; Serine | 1985 |
Effects of acetaminophen on cadmium metabolism in mice.
Topics: Acetaminophen; Animals; Body Burden; Cadmium; Chromatography, Gel; Cysteine; Feces; Kidney; Liver; Male; Metallothionein; Mice; Phenobarbital | 1986 |
Acetaminophen in the guinea pig: metabolite identification in blood, urine, and bile.
Topics: Absorption; Acetaminophen; Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Cysteine; Glucuronates; Guinea Pigs; Half-Life; Kinetics; Male; Sulfates | 1986 |
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteine; Glucuronates; Glucuronic Acid; Glutathione; Kinetics; Liver; Liver Glycogen; Male; Mice; Phosphoadenosine Phosphosulfate; Protein Binding; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1986 |
Acetaminophen metabolite interferes in analysis for amino acids.
Topics: Acetaminophen; Amino Acids; Cysteine; False Positive Reactions; Humans; Phenylalanine | 1985 |
Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins.
Topics: Acetaminophen; Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Cysteine; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred BALB C; Proteins | 1985 |
Role of sulfhydryls in the hepatotoxicity of organic and metallic compounds.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 Enzyme System; Humans; Metallothionein; Metals; Microsomes, Liver; Sulfhydryl Compounds; Zinc | 1985 |
Proceedings: Urinary paracetamol metabolites following paracetamol overdose in man.
Topics: Acetaminophen; Cysteine; Glutathione; Humans; Liver; Suicide | 1974 |
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Dimercaprol; Enzymes; Flavonoids; Glutathione; Lethal Dose 50; Liver; Male; Mice; Penicillamine; Poisoning; Thiazoles; Thiocarbamates; Thioctic Acid | 1974 |
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
Topics: Acetaminophen; Animals; Autoradiography; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Maleates; Mice; Mice, Inbred Strains; Necrosis; Time Factors; Tritium | 1973 |
Acetaminophen metabolism in man, as determined by high-resolution liquid chromatography.
Topics: Acetaminophen; Adult; Cerium; Chromatography, Gas; Chromatography, Ion Exchange; Cysteine; Glucuronates; Humans; Male; Mass Spectrometry; Methyl Ethers; Middle Aged; Spectrophotometry, Ultraviolet; Sulfuric Acids; Time Factors | 1974 |
Drug biotransformation interactions in man. 3. Acetaminophen and salicylamide.
Topics: Acetaminophen; Adult; Biotransformation; Colorimetry; Cysteine; Glucuronates; Humans; Male; Salicylamides; Spectrophotometry; Sulfates; Time Factors | 1971 |
[Susceptibility of the liver to lipid peroxidation after treatment with paracetamol].
Topics: Acetaminophen; Adenosine Triphosphatases; Animals; Cell Membrane; Cysteine; Glutathione; Lipid Metabolism; Liver; Male; Microsomes, Liver; Nucleotidases; Rats; Tiopronin | 1981 |
Characteristics of the uptake of cysteine-containing leukotrienes by isolated hepatocytes.
Topics: Acetaminophen; Animals; Biological Transport; Cysteine; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Leukotriene B4; Leukotriene E4; Liver; Male; Rats; Rats, Inbred Strains; SRS-A; Temperature; Tritium | 1983 |
Drug protein conjugates--VI. Role of glutathione in the metabolism of captopril and captopril plasma protein conjugates.
Topics: Acetaminophen; Alanine Transaminase; Animals; Ascorbic Acid; Blood Proteins; Captopril; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred CBA; Penicillamine; Proline; Protein Binding; Rats; Rats, Inbred Strains | 1983 |
Effects of metals and organic compounds on hepatic glutathione, cysteine, and acid-soluble thiol levels in mullet (Mugil cephalus L.).
Topics: Acetaminophen; Animals; Benzofurans; Cadmium; Cysteine; Fishes; Fluorenes; Food Deprivation; Fuel Oils; Glutathione; Glycine; Liver; Mercury; Pentachlorophenol; Sulfhydryl Compounds | 1984 |
Mechanism of action of paracetamol protective agents in mice in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Buthionine Sulfoximine; Cysteamine; Cysteine; Glutathione; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
Sex related differences in acetaminophen toxicity in the mouse.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cysteine; Female; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Sex Factors | 1984 |
A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Carbocysteine; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteine; Humans; In Vitro Techniques; Kidney; Male; Mesocricetus; Microsomes, Liver; Protein Binding | 1983 |
The effect of cysteine and N-acetyl cysteine on rat liver glutathione (GSH).
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Cysteine; Glutathione; Injections, Intraperitoneal; Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1983 |
The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro.
Topics: Acetaminophen; Amino Acids; Animals; Benzoquinones; Caseins; Cysteine; Glutathione; Imines; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; NADP; Phenobarbital; Proteins; Serum Albumin, Bovine | 1984 |
2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cysteine; Indicators and Reagents; Kinetics; Liver; Male; Mice; Mitochondria, Liver; Proline Oxidase; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles | 1984 |
Effects of variation in the dietary supply of cysteine and methionine on liver concentration of glutathione and "active sulfate" (PAPS) and serum levels of sulfate, cystine, methionine and taurine: relation to the metabolism of acetaminophen.
Topics: Acetaminophen; Animals; Cysteine; Cystine; Diet; Glutathione; Growth; Liver; Male; Methionine; Phosphoadenosine Phosphosulfate; Rats; Rats, Inbred Strains; Sulfates; Taurine | 1983 |
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.
Topics: Acetaminophen; Animals; Cysteine; Glutathione; Glutathione Synthase; Inactivation, Metabolic; Liver; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1982 |
Effects of microsomal enzyme induction on paracetamol metabolism in man.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Anticonvulsants; Antipyrine; Cysteine; Enzyme Induction; Female; Half-Life; Humans; Liver; Male; Microsomes, Liver; Middle Aged | 1981 |
Renal metabolism of paracetamol: studies in the isolated perfused rat kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Kidney Tubules; Rats; Time Factors | 1980 |
Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.
Topics: Acetaminophen; Animals; Ascorbic Acid; Benzoquinones; Cysteine; Imines; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Rats | 1980 |
An integrated approach to the study of chemically reactive metabolites of acetaminophen.
Topics: Acetaminophen; Animals; Antidotes; Biotransformation; Cricetinae; Cysteamine; Cysteine; Dose-Response Relationship, Drug; Glutathione; Liver; Mice; Necrosis; Rats | 1981 |
Sulphoxidation and sulphation capacity in patients with primary biliary cirrhosis.
Topics: Acetaminophen; Adult; Carbocysteine; Case-Control Studies; Cysteine; Female; Humans; Liver Cirrhosis, Biliary; Male; Middle Aged; Oxidation-Reduction; Ranitidine; Reference Values; Sulfoxides; Sulfuric Acid Esters | 1995 |
The estimation of paracetamol and its major metabolites in both plasma and urine by a single high-performance liquid chromatography assay.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Cysteine; Humans; Spectrophotometry, Ultraviolet | 1994 |
Metabolic basis for high paracetamol dosage without hepatic injury: a case study.
Topics: Acetaminophen; Administration, Oral; Cysteine; Female; Follow-Up Studies; Glutathione; Humans; Liver; Middle Aged | 1995 |
(Z)-3-(4-bromophenyl)-3-(3-pyridyl)allylamine as substrate for studies of myeloperoxidase activity.
Topics: Acetaminophen; Chlorides; Chromatography, Thin Layer; Cysteamine; Cysteine; Gas Chromatography-Mass Spectrometry; Hypochlorous Acid; Magnetic Resonance Spectroscopy; Parabens; Peroxidase; Phenylacetates; Phenylpropionates; Pyridazines; Spectrophotometry, Ultraviolet; Substrate Specificity; Zimeldine | 1995 |
Synthesis rates of glutathione and activated sulphate (PAPS) and response to cysteine and acetaminophen administration in glutathione-depleted rat hepatocytes.
Topics: Acetaminophen; Animals; Cells, Cultured; Cysteine; Glutathione; Liver; Maleates; Phosphoadenosine Phosphosulfate; Rats | 1993 |
The disposition of paracetamol and its conjugates during multiple dosing in patients with end-stage renal failure maintained on haemodialysis.
Topics: Acetaminophen; Administration, Oral; Adult; Cysteine; Drug Administration Schedule; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 1993 |
[A case of prolonged liver injury caused by low dose of acetaminophen--the involvement of other multiple drugs such as Proheparum and Mazulene-S was considered in this drug-induced hepatitis].
Topics: Acetaminophen; Adult; Azulenes; Bis-Trimethylammonium Compounds; Chemical and Drug Induced Liver Injury; Cysteine; Drug Combinations; Female; Humans; Inositol; Liver; Liver Extracts; Sesquiterpenes; Vitamin B 12 | 1993 |
Attenuation of acetaminophen hepatotoxicity in mice as evidence for the bioavailability of the cysteine in D-glucose-L-cysteine in vivo.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Biological Availability; Cysteine; Drug Interactions; Glucose; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred ICR | 1994 |
Liver damage and plasma concentrations of paracetamol and its metabolites after paracetamol overdosage in mice.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Cysteine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Liver; Male; Mice | 1993 |
Prevention of acetaminophen- and naphthalene-induced cataract and glutathione loss by CySSME.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cataract; Chromatography, High Pressure Liquid; Cysteine; Drug Combinations; Glutathione; Lens, Crystalline; Liver; Male; Mercaptoethanol; Mice; Mice, Inbred C57BL; Naphthalenes; Organ Culture Techniques; Prodrugs; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms | 1996 |
Maintenance of hepatic glutathione homeostasis and prevention of acetaminophen-induced cataract in mice by L-cysteine prodrugs.
Topics: Acetaminophen; Animals; Cataract; Cysteine; Glutathione; Homeostasis; Liver; Male; Mice; Mice, Inbred C57BL; Prodrugs | 1996 |
Immunochemical detection of drug-protein adducts in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Chromatography, Ion Exchange; Cysteine; Cytosol; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred Strains; Proteins; Selenium | 1996 |
Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine.
Topics: Acetaminophen; Animals; Binding Sites; Blotting, Western; Cysteine; Immune Sera; Liver; Mice | 1996 |
Studies comparing the kinetics of cysteine conjugation and protein binding of acetaminophen by hepatic microsomes from male mice.
Topics: Acetaminophen; Animals; Cysteine; Cytochrome P-450 CYP2E1; Ethanol; Male; Mice; Microsomes, Liver; NAD; NADP; Protein Binding | 1997 |
Catalysis of the cysteine conjugation and protein binding of acetaminophen by microsomes from a human lymphoblast line transfected with the cDNAs of various forms of human cytochrome P450.
Topics: Acetaminophen; Catalysis; Cell Line; Cysteine; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Isoenzymes; Protein Binding | 1997 |
Protection against acetaminophen-induced hepatotoxicity by L-CySSME and its N-acetyl and ethyl ester derivatives.
Topics: Acetaminophen; Alanine Transaminase; Animals; Confidence Intervals; Cysteine; Liver; Liver Function Tests; Male; Mercaptoethanol; Mice; Mice, Inbred Strains; Prodrugs | 1996 |
2-Methyl-thiazolidine-2,4-dicarboxylic acid protects against paracetamol induced toxicity in human liver derived HepG2 cells.
Topics: Acetaminophen; Antidotes; Benzoquinones; Cell Line; Cysteine; Glutathione; Humans; Imines; Liver; Malondialdehyde; Oxidation-Reduction; Prodrugs; Reactive Oxygen Species; Thiazoles; Thiazolidines | 1997 |
Differential chemoprotection against acetaminophen-induced hepatotoxicity by latentiated L-cysteines.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Disaccharides; Glutathione; Mice; Prodrugs; Quinone Reductases; RNA, Messenger | 1998 |
Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Coenzymes; Cysteine; Cytochrome P-450 CYP2E1; Glucuronosyltransferase; Glutathione; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Proteins; Sulfhydryl Compounds; Sulfotransferases; Ubiquinone; Vitamin E | 1998 |
Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct.
Topics: Acetaminophen; Ascorbic Acid; Benzoquinones; Cysteine; Glutathione; Half-Life; Imines; Macromolecular Substances; Papain; Proteins; Sulfhydryl Compounds | 1999 |
L-2-[(13)C]oxothiazolidine-4-carboxylic acid: a probe for precursor mobilization for glutathione synthesis.
Topics: Acetaminophen; Adult; Aged; Breath Tests; Calorimetry, Indirect; Carbon Dioxide; Cysteine; Female; Glutathione; Humans; Kinetics; Male; Middle Aged; Models, Biological; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2000 |
Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice.
Topics: Acetaminophen; Aging; Animals; Buthionine Sulfoximine; Cysteine; Glutathione; Kidney Cortex; Liver; Male; Mice; Mice, Inbred C57BL | 2000 |
Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice.
Topics: Acetaminophen; Aldehydes; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Glutathione Disulfide; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Prodrugs; Protective Agents; Thiazoles | 2001 |
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.
Topics: Acetaminophen; Acetylation; Alanine Transaminase; Aminophenols; Animals; Ascorbic Acid; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cysteine; Cystine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Glutathione Disulfide; L-Iditol 2-Dehydrogenase; Liver; Male; Mice; Mice, Inbred C57BL | 2001 |
Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Brain; Cysteine; Drug Interactions; Glutathione; Hepatocytes; In Vitro Techniques; Kidney Cortex; Male; Mice; Mice, Inbred C57BL; Prodrugs; Sulfhydryl Compounds; Thiazoles; Tissue Distribution | 2001 |
Spatial glutathione and cysteine distribution and chemical modulation in the early organogenesis-stage rat conceptus in utero.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Chromatography, High Pressure Liquid; Cysteine; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fluorescence; Glutathione; Histocytochemistry; Liver; Phenylmercury Compounds; Pregnancy; Rats; Rats, Sprague-Dawley; Staining and Labeling; Time Factors; Tissue Distribution | 2001 |
Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cysteine; Cytochrome P-450 CYP2E1; Glutathione; Glutathione Disulfide; HSP70 Heat-Shock Proteins; Liver; Male; Mice; Protective Agents | 2001 |
Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Child; Chromatography, High Pressure Liquid; Cysteine; Endopeptidases; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Predictive Value of Tests; Proteins; Sensitivity and Specificity; Time Factors; Tyrosine | 2002 |
Acetaminophen-induced suppression of hepatic AdoMet synthetase activity is attenuated by prodrugs of L-cysteine.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Cysteine; Glutathione; Liver; Male; Methionine Adenosyltransferase; Mice; Mitochondria, Liver; Prodrugs | 2002 |
Double-prodrugs of L-cysteine: differential protection against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Prodrugs; Structure-Activity Relationship | 2002 |
Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Free Radical Scavengers; Glutathione; Mice; Prodrugs | 2003 |
Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine.
Topics: Acetaminophen; Animals; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney Cortex; Kidney Diseases; Liver; Male; Mice; Mice, Inbred Strains; Sulfhydryl Compounds; Toxicity Tests | 2005 |
Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle.
Topics: Acetaminophen; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Injections, Intraperitoneal; Isoxazoles; Kidney Diseases; Kidney Tubules, Proximal; Male; Mass Spectrometry; Mice; Mice, Inbred Strains; Microvilli; Molecular Structure; Toxicity Tests | 2005 |
Effects of dietary antioxidant supplementation before and after oral acetaminophen challenge in cats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Biomarkers; Cats; Chromatography, High Pressure Liquid; Cysteine; Dietary Supplements; Drug Therapy, Combination; Female; Glutathione; Guanine; Lymphocyte Activation; Lymphocytes; Male; Methemoglobin; Thioctic Acid; Vitamin E | 2005 |
Differences in the single-oral-dose pharmacokinetics and urinary excretion of paracetamol and its conjugates between Hong Kong Chinese and Caucasian subjects.
Topics: Acetaminophen; Administration, Oral; Adult; Area Under Curve; Asian People; Body Height; Body Weight; Cysteine; Drug Administration Schedule; Female; Glucuronides; Half-Life; Hong Kong; Humans; Male; Metabolic Clearance Rate; Sulfates; White People | 2005 |
Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; In Vitro Techniques; Kidney; Kidney Diseases; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Prodrugs; Protective Agents; Thiazoles; Thiazolidines | 2005 |
Protective effect of s-allyl cysteine and s-propyl cysteine on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; C-Reactive Protein; Cysteine; Glutathione; Glutathione Peroxidase; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Oxidative Stress; Protective Agents | 2006 |
A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients.
Topics: Acetaminophen; Adult; Area Under Curve; beta-Thalassemia; Bilirubin; Cysteine; Female; Glucuronosyltransferase; Humans; Male; Middle Aged | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cysteine; Female; Humans; Infant; Infant, Newborn; Liver; Liver Failure, Acute; Male; Protein Binding; Sensitivity and Specificity | 2006 |
Acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Child; Cysteine; Humans; Liver Failure, Acute; Protein Binding | 2007 |
Protein targets of reactive electrophiles in human liver microsomes.
Topics: Acetaminophen; Alkylating Agents; Biotin; Blotting, Western; Calreticulin; Cell Line; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Glutathione Transferase; Humans; Iodoacetamide; Microsomes, Liver; Molecular Structure; Protein Binding; Proteins; Tandem Mass Spectrometry | 2007 |
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, Liquid; Cysteine; Humans; Imines; Microsomes, Liver; Models, Biological; Molecular Structure; Oligopeptides; Protein Binding; Rats; Reproducibility of Results; Serum Albumin; Tandem Mass Spectrometry | 2007 |
Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.
Topics: Acetaminophen; Amino Acid Sequence; Benzoquinones; Cells, Cultured; Cysteine; Glutathione S-Transferase pi; Humans; Imines; Models, Molecular; Molecular Sequence Data; Proteomics | 2008 |
Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cysteine; Dose-Response Relationship, Drug; Female; Humans; Male; Molecular Structure; Pain; Time; Young Adult | 2009 |
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Aspartate Aminotransferases; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Glutathione; Humans; Hydrogen Peroxide; Liver; Liver Diseases; Lysophosphatidylcholines; Male; Metabolomics; Mice; Mice, Knockout; Mice, Transgenic; Necrosis; Oxidative Stress; Pregnane X Receptor; Principal Component Analysis; Receptors, Steroid; Rifampin; RNA, Messenger; Time Factors | 2009 |
Alteration in metabolism and toxicity of acetaminophen upon repeated administration in rats.
Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Analgesics, Non-Narcotic; Animals; Anisoles; Aspartate Aminotransferases; Cysteine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; Liver; Microsomes, Liver; Nitrophenols; Rats; Rats, Sprague-Dawley | 2009 |
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glutathione; Hep G2 Cells; Humans; Mice; Models, Biological; Necrosis; Reactive Nitrogen Species; Reactive Oxygen Species | 2011 |
Detection of acetaminophen-cysteine adducts in cases of indeterminate liver failure is not diagnostic of intentional overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteine; Drug Overdose; Humans; Liver Failure, Acute | 2011 |
Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
Topics: Acetaminophen; Bacterial Proteins; Chromans; Chromatography, High Pressure Liquid; Clozapine; Cysteine; Cytochrome P-450 Enzyme System; Glutathione Transferase; Humans; Inactivation, Metabolic; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Peptides; Protein Binding; Recombinant Fusion Proteins; Tandem Mass Spectrometry; Thiazolidinediones; Troglitazone; Trypsin | 2011 |
Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Blotting, Western; Chemical and Drug Induced Liver Injury; Cysteine; Cytoplasm; Liver; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Mitochondria, Liver; Nitrates; Nitric Oxide Synthase Type I; Oxidative Stress; Superoxide Dismutase | 2012 |
Determination of paracetamol based on its quenching effect on the photoluminescence of CdTe fluorescence probes.
Topics: Acetaminophen; Cadmium Compounds; Cysteine; Fluorescent Dyes; Luminescence; Nanoparticles; Particle Size; Surface Properties; Tellurium | 2012 |
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cysteine; HMGB1 Protein; Humans; Macrophages; Male; Mice; Oxidation-Reduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2012 |
A novel sensor of cysteine self-assembled monolayers over gold nanoparticles for the selective determination of epinephrine in presence of sodium dodecyl sulfate.
Topics: Acetaminophen; Ascorbic Acid; Cysteine; Electrochemical Techniques; Electrodes; Epinephrine; Gold; Humans; Hydrogen-Ion Concentration; Metal Nanoparticles; Oxidation-Reduction; Sodium Dodecyl Sulfate | 2012 |
Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning.
Topics: Acetaminophen; Aldehyde Oxidase; Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Drug Overdose; Glutathione; JNK Mitogen-Activated Protein Kinases; Liver; Male; Metallothionein; Mice; Mice, Inbred C3H; Mitochondria; Oxypurinol; Phosphorylation; Xanthine Oxidase | 2014 |
Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studies; Cysteine; Drug Overdose; Female; Half-Life; Hemodiafiltration; Humans; Male; Prospective Studies; Proteins; Renal Circulation; Renal Insufficiency; Tandem Mass Spectrometry | 2015 |
Skeletal muscle wasting occurs in adult rats under chronic treatment with paracetamol when glutathione-dependent detoxification is highly activated.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Cysteine; Feces; Glutathione; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Nitrogen; Rats, Wistar | 2014 |
Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Centrifugation; Cysteine; Dialysis; Drug Overdose; Female; Humans; Liver Failure, Acute; Liver Function Tests | 2015 |
Protein-Derived Acetaminophen-Cysteine Can Be Detected After Repeated Supratherapeutic Ingestion of Acetaminophen in the Absence of Hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Cysteine; Drug Administration Schedule; Female; Humans; Interviews as Topic; Liver Function Tests; Male; Middle Aged; Pain; Pain Clinics; Protein Binding; Risk Factors; Surveys and Questionnaires; Time Factors; Transaminases; Treatment Outcome | 2015 |
Protein-derived acetaminophen-cysteine detection from chronic APAP is not dose-dependent.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cysteine; Female; Humans; Male; Pain | 2015 |
Reply to Dr. Regina and colleagues re: protein-derived acetaminophen-cysteine in supratherapeutic ingestion.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cysteine; Female; Humans; Male; Pain | 2015 |
Differential protein labeling based on electrochemically generated reactive intermediates.
Topics: Acetaminophen; Animals; Benzoquinones; Carbonic Anhydrase I; Cattle; Chromatography, Liquid; Cysteine; Electrochemical Techniques; Equipment Design; Glutathione; Hemoglobins; Humans; Isotope Labeling; Lactoglobulins; Oxidation-Reduction; Phenol; Proteins; Serum Albumin; Spectrometry, Mass, Electrospray Ionization | 2015 |
Acetaminophen metabolism after liver resection: A prospective case-control study.
Topics: Acetaminophen; Aged; Biomarkers; Case-Control Studies; Cysteine; Female; Glutathione; Hepatectomy; Humans; Liver; Male; Middle Aged; Prospective Studies; United Kingdom | 2015 |
NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Betaine; Blotting, Western; Cells, Cultured; Cysteine; Female; Glutathione; Hep G2 Cells; Homocysteine; Humans; Immunoenzyme Techniques; Liver; Liver Diseases; Methionine; Mice; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; Reactive Oxygen Species; S-Adenosylmethionine | 2015 |
Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Area Under Curve; Body Mass Index; Cysteine; Cytochrome P-450 CYP2E1; Female; Humans; Male; Middle Aged; Models, Biological; Obesity, Morbid; Prospective Studies; Young Adult | 2016 |
Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.
Topics: Acetaminophen; Aldehyde Reductase; Animals; Ascorbic Acid; Autophagy; Crosses, Genetic; Cysteine; Genotype; Glutathione; Guinea Pigs; Hepatocytes; Immunohistochemistry; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Reactive Oxygen Species | 2016 |
Serum Acetaminophen Protein Adduct Concentrations in Pediatric Emergency Department Patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cross-Sectional Studies; Cysteine; Drug Overdose; Emergency Service, Hospital; Female; Humans; Infant; Male; Reference Values | 2017 |
xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway.
Topics: Acetaminophen; Amino Acid Transport System y+; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Male; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction | 2017 |
Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.
Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Capsaicin; Cell Death; Cysteine; Ganglia, Spinal; HEK293 Cells; Hepatocytes; Humans; Imines; Intracellular Space; Ion Channel Gating; Male; Metabolome; Mice, Inbred C57BL; Pain; Phosphorylation; Reducing Agents; Reflex; Regional Blood Flow; Skin; TRPV Cation Channels | 2017 |
Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Carrageenan; Chemical and Drug Induced Liver Injury; Cysteine; Edema; Free Radicals; Hyperlipidemias; Lipid Peroxidation; Oxidative Stress; Parabens; Protective Agents; Rats | 2017 |
Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cysteine; Dietary Supplements; Glutathione; Homocysteine; Liver; Male; Muscle, Skeletal; Rats; Rats, Wistar; Sarcopenia | 2017 |
Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholestyramine Resin; Cysteine; Free Radical Scavengers; Glutathione; Hepatocytes; Homeostasis; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2018 |
Activated charcoal significantly improved the reliability of methods for quantitative analysis of endogenous substances in biological specimens: Glutathione and cysteine as cases.
Topics: Acetaminophen; Animals; Charcoal; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Drug Stability; Glutathione; Limit of Detection; Linear Models; Liver; Male; Mice; Mice, Inbred C57BL; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2018 |
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Edema; Exanthema; Glutathione; Humans; Imines; Male; Protein Binding; Serum Albumin; Skin Diseases; Tandem Mass Spectrometry | 2019 |
Microsomal prostaglandin E synthase 2 deficiency is resistant to acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dinoprostone; Glutathione; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-E Synthases | 2019 |
A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition.
Topics: Acetaminophen; Animals; Bupleurum; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Liver; Male; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Rats, Wistar | 2019 |
Dried blood microsamples: Suitable as an alternative matrix for the quantification of paracetamol-protein adducts?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Specimen Collection; Cysteine; Dried Blood Spot Testing; Hematocrit; Humans; Protein Binding; Quality Control | 2020 |
Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates.
Topics: Acetaminophen; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cysteine; Glutathione; HEK293 Cells; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins | 2020 |
Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats.
Topics: Acetaminophen; Animals; Animals, Newborn; Behavior, Animal; Cysteine; Female; Male; Mannitol; Neurogenesis; Rats; Rats, Sprague-Dawley | 2021 |
Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cysteine; Glutathione; Glycyrrhizic Acid; Kelch-Like ECH-Associated Protein 1; Liver; Mice; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction | 2022 |
Effects of dietary restriction on hepatic sulfur-containing amino acid metabolism and its significance in acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL; Sulfur | 2022 |
Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine.
Topics: Acetaminophen; Activating Transcription Factor 4; Animals; Cysteine; Dietary Supplements; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Glutathione; Mammals; Muscular Atrophy; Phosphorylation | 2022 |
Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen.
Topics: Acetaminophen; Biomarkers; Cysteic Acid; Cysteine; Disulfides; Hepatocytes; HMGB1 Protein; Oxidation-Reduction; Peptides; Proteins; Sulfhydryl Compounds | 2022 |
Optimizing phenyl selenide-based BODIPYs as fluorescent probes for diagnosing cancer and drug-induced liver injury
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Fluorescent Dyes; Liver; Mice; Neoplasms | 2022 |
Detection of Distinct Distributions of Acetaminophen and Acetaminophen-Cysteine in Kidneys up to 10 μm Resolution and Identification of a Novel Acetaminophen Metabolite Using an AP-MALDI Imaging Mass Microscope.
Topics: Acetaminophen; Cysteine; Kidney; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2023 |
Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells.
Topics: Acetaminophen; Aminophenols; Cysteine; Glutathione; Humans; Kidney | 2023 |