acetaminophen and cyclosporine

acetaminophen has been researched along with cyclosporine in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (10.64)	18.2507
2000's	17 (36.17)	29.6817
2010's	22 (46.81)	24.3611
2020's	3 (6.38)	2.80

Authors

Authors	Studies
Chang, TK; Ensom, MH; Kiang, TK	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Beales, D; McLean, AE	1
Kim, MS; Kim, SI; Kim, YS; Oh, CK; Park, K	1
Baker, P; Bensen, W; Gent, M; Grace, E; Ludwin, D; Roberts, R; Tugwell, P	1
Curti, C; Mingatto, FE; Pigoso, AA; Rodrigues, T; Santos, AC; Uyemura, SA	1
Hoshino, N; Minouchi, T; Ohmae, T; Shibata, N; Yamaji, A	1
Chojnowski, K; Góra-Tybor, J; Robak, E; Robak, T; Strzelecka, B; Sysa-Jedrzejowska, A; Waszczykowska, E	1
Damato, R; Di Poi, E; Favret, G; Ferraccioli, GF; Gremese, E; Tomietto, P	1
Hartung, T; Jennings, P; Koppelstaetter, C; Morin, JP; Pfaller, W; Ryan, MP	1
Justo, P; Lorz, C; Marrón, B; Ortiz, A; Sanz, A	1
Jaeschke, H; Kim, JS; Kon, K; Lemasters, JJ	1
Horie, T; Masubuchi, Y; Suda, C	1
Szegedi, J	1
Aoyama, T; Arai, K; Ikejima, K; Kon, K; Lemasters, JJ; Okumura, K; Sato, N; Takei, Y	1
Baken, KA; Breit, TM; de Vries, A; Jonker, MJ; Pennings, JL; Schaap, MM; van Loveren, H; van Steeg, H	1
Azarpira, N; Baghban, M; Jamshidzadeh, A; Mohammadi Bardbori, A; Niknahad, H	1
Inoue, D; Kimura, T; Kurata, M; Maruoka, H; Matsushita, A; Mori, M; Nagai, K; Nagai, Y; Shimoji, S; Tabata, S; Takahashi, T; Yamashita, E	1
Förger, F; Østensen, M	1
Bouwman, FG; Kleinjans, JC; Mariman, EC; Noben, JP; Renes, J; van Delft, JH; Van Summeren, A	1
Chaudhuri, S; Hennings, L; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Simpson, PM	1
Gilson, R; Henning, JS; Ladd, D; Reese, D; Rockers, K	1
Jaeschke, H; McGill, MR; Ramachandran, A	1
Bouwman, FG; Kleinjans, JC; Lizarraga, D; Mariman, EC; Noben, JP; Renes, J; van Delft, JH; Van Summeren, A	1
Abe, N; Aritomi, K; Irie, T; Irikura, M; Ishitsuka, Y; Kai, H; Shimizu, D; Shuto, T; Tomishima, Y	1
Driessen, M; Kienhuis, AS; Pennings, JL; van der Ven, LT; Vitins, AP; Water, Bv	1
Hu, J; Jaeschke, H; Lemasters, JJ; McGill, MR; Ramshesh, VK	1
Gore, E; Groothuis, GM; Olinga, P; Pennings, JL; Vatakuti, S	1
Nakamura, R; Saito, Y	1
Reamy, BV; Servey, JT; Williams, PM	1
Enver Ozan, İ; Erdem Güzel, E; Gül, M; Kavak Balgetir, M; Kaya Tektemur, N; Ozan Kocamüftüoğlu, G; Özcan Yıldırım, S; Tektemur, A; Yalçın, T	1
Callegaro, G; den Hollander, W; Furlong, L; Grosdidier, S; Guney, E; Kunnen, SJ; Mollon, J; Niemeijer, M; Piñero Gonzalez, J; Saez-Rodriguez, J; Stevens, JL; Sutherland, JJ; Trairatphisan, P; van de Water, B; Webster, YW	1

Reviews

8 review(s) available for acetaminophen and cyclosporine

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[New molecular mechanisms of nephrotoxicity]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2004, Volume: 24, Issue:2 Topics: Acetaminophen; Apoptosis; bcl-X Protein; Caspase 8; Caspases; Cyclosporine; Cysteine Proteinase Inhibitors; Cytokines; Endoplasmic Reticulum; Epithelium; fas Receptor; Humans; Kidney Diseases; Kidney Tubules; Mitochondria; Models, Biological; Proto-Oncogene Proteins c-bcl-2	2004
[Renal insufficiency caused by medicines, diagnostic processes, toxins]. Orvosi hetilap, 2007, Jan-21, Volume: 148, Issue:3 Topics: Acetaminophen; Acute Kidney Injury; Aminoglycosides; Amphotericin B; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Cisplatin; Contrast Media; Cyclosporine; Foscarnet; Humans; Hungary; Ischemia; Kidney; Kidney Function Tests; Pentamidine; Prognosis	2007
Management of RA medications in pregnant patients. Nature reviews. Rheumatology, 2009, Volume: 5, Issue:7 Topics: Abatacept; Acetaminophen; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Contraindications; Cyclosporine; Female; Gestational Age; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Rituximab; Sulfasalazine; Young Adult	2009
Cyclosporine for SJS/TEN: a case series and review of the literature. Cutis, 2011, Volume: 87, Issue:1 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Infective Agents; Anticonvulsants; Cyclosporine; Dermatologic Agents; Drug Combinations; Female; Humans; Lamotrigine; Male; Stevens-Johnson Syndrome; Sulfamethizole; Triazines; Trimethoprim	2011
[Mechanisms of Severe Cutaneous Adverse Reactions and a New Treatment Strategy]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Volume: 139, Issue:12 Topics: Acetaminophen; Adrenal Cortex Hormones; Allopurinol; Antigens, Differentiation, T-Lymphocyte; Carbamazepine; CD8-Positive T-Lymphocytes; Cyclosporine; Epidermis; Etanercept; Fas Ligand Protein; HLA Antigens; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Japan; Lamotrigine; Plasma Exchange; Stevens-Johnson Syndrome; Tumor Necrosis Factor-alpha	2019
Henoch-Schönlein Purpura (IgA Vasculitis): Rapid Evidence Review. American family physician, 2020, 08-15, Volume: 102, Issue:4 Topics: Acetaminophen; Adrenal Cortex Hormones; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Child; Cyclosporine; Disease Progression; Glomerulonephritis; Humans; IgA Vasculitis; Immunosuppressive Agents; Mycophenolic Acid; Nephrology; Recurrence; Referral and Consultation; Remission, Spontaneous; Urinalysis	2020

Trials

3 trial(s) available for acetaminophen and cyclosporine

Article	Year
Treatment of steroid resistant acute rejection after renal transplantation. Transplantation proceedings, 1996, Volume: 28, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antilymphocyte Serum; Cyclosporine; Diphenhydramine; Drug Resistance; Graft Rejection; Histamine H1 Antagonists; Humans; Hydrocortisone; Immunosuppressive Agents; Kidney Transplantation; Methylprednisolone; Muromonab-CD3; Recurrence	1996
Interaction between cyclosporin A and nonsteroidal antiinflammatory drugs. The Journal of rheumatology, 1997, Volume: 24, Issue:6 Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Creatinine; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Glomerular Filtration Rate; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Treatment Outcome	1997
Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years. Rheumatology (Oxford, England), 2002, Volume: 41, Issue:8 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease-Free Survival; Drug Therapy, Combination; Female; HLA-DR1 Antigen; Humans; Male; Methotrexate; Middle Aged; Pain; Sulfasalazine	2002

Other Studies

36 other study(ies) available for acetaminophen and cyclosporine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Protection in the late stages of paracetamol-induced liver cell injury with fructose, cyslosporin A and trifluoperazine. Toxicology, 1996, Mar-18, Volume: 107, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Cell Death; Cyclosporine; Drug Combinations; Fructose; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Membrane Potentials; Microtomy; Mitochondria, Liver; Rats; Rats, Wistar; Trifluoperazine	1996
Influence of nonsteroidal anti-inflammatory drugs on calcium efflux in isolated rat renal cortex mitochondria and aspects of the mechanisms involved. The international journal of biochemistry & cell biology, 1998, Volume: 30, Issue:9 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclosporine; Diclofenac; Dipyrone; Ibuprofen; In Vitro Techniques; Ion Transport; Kidney Cortex; Male; Mefenamic Acid; Mitochondria; NAD; NADP; Oxidation-Reduction; Piroxicam; Rats; Rats, Wistar; Salicylic Acid	1998
Influence of glycerol-induced acute renal failure on the pharmacokinetics of cyclosporin in rats. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:4 Topics: Acetaminophen; Acute Kidney Injury; Administration, Oral; Analgesics, Non-Narcotic; Animals; Area Under Curve; Blood Urea Nitrogen; Creatine; Cyclosporine; Gastric Emptying; Glycerol; Ileum; Immunosuppressive Agents; In Vitro Techniques; Injections, Intravenous; Jejunum; Liver; Male; Rats; Rats, Sprague-Dawley; Time Factors	1999
Toxic epidermal necrolysis in a patient with severe aplastic anemia treated with cyclosporin A and G-CSF. Journal of medicine, 2001, Volume: 32, Issue:1-2 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anemia, Aplastic; Cyclosporine; Granulocyte Colony-Stimulating Factor; Humans; Male; Penicillin V; Penicillins; Severity of Illness Index; Stevens-Johnson Syndrome	2001
Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 2: toxicological evaluation. ALTEX, 2004, Volume: 21, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animal Testing Alternatives; Animals; Cell Culture Techniques; Coloring Agents; Cyclosporine; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Humans; Immunosuppressive Agents; Inhibitory Concentration 50; Kidney Diseases; L-Lactate Dehydrogenase; LLC-PK1 Cells; Oxazines; Perfusion; Sodium Dodecyl Sulfate; Surface-Active Agents; Swine; Time Factors; Toxicity Tests, Chronic; Xanthenes	2004
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:5 Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cyclosporine; Drug Synergism; Fructose; Glycine; Hepatocytes; Immunosuppressive Agents; Ion Channels; Male; Mice; Mice, Inbred Strains; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Necrosis; Time Factors	2004
Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. Journal of hepatology, 2005, Volume: 42, Issue:1 Topics: Acetaminophen; Adenosine Triphosphate; Animals; Benzoquinones; Calcium; Cyclosporine; Glutathione Disulfide; Imines; Liver; Male; Membrane Potentials; Mice; Mitochondria, Liver; Permeability	2005
Role of apoptosis in acetaminophen hepatotoxicity. Journal of gastroenterology and hepatology, 2007, Volume: 22 Suppl 1 Topics: Acetaminophen; Animals; Apoptosis; Cell Membrane Permeability; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione; Mice; Microscopy, Confocal; Mitochondria, Liver; Necrosis; Oxidative Stress	2007
Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening. Toxicology and applied pharmacology, 2008, Jan-01, Volume: 226, Issue:1 Topics: Acetaminophen; Animals; Benzo(a)pyrene; Body Weight; Cell Cycle; Cyclosporine; Gene Expression Profiling; Gene Expression Regulation; Immune System; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Spleen; Trialkyltin Compounds	2008
Effects of tomato extract on oxidative stress induced toxicity in different organs of rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:12 Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione; Immunosuppressive Agents; Kidney Diseases; Lipid Peroxidation; Lung Diseases; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Solanum lycopersicum	2008
[Angioimmunoblastic T-cell lymphoma complicated by recurrent drug-induced agranulocytosis]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2009, Volume: 50, Issue:2 Topics: Acetaminophen; Aged; Agranulocytosis; Analgesics, Non-Narcotic; Cyclosporine; Humans; Immunoblastic Lymphadenopathy; Immunosuppressive Agents; Lymphoma, T-Cell; Male; Recurrence	2009
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 120, Issue:1 Topics: Acetaminophen; Amiodarone; Blotting, Western; Cell Survival; Chemical and Drug Induced Liver Injury; Cluster Analysis; Cyclosporine; Drug-Related Side Effects and Adverse Reactions; Electrophoresis, Gel, Two-Dimensional; Hep G2 Cells; Humans; Pharmaceutical Preparations; Protein Biosynthesis; Protein Processing, Post-Translational; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry	2011
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia. Toxicology and applied pharmacology, 2011, May-01, Volume: 252, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitroimidazoles; Oxidative Stress; Statistics, Nonparametric	2011
Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 121, Issue:2 Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclosporine; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Proteomics	2011
Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach. Omics : a journal of integrative biology, 2013, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Animals; Cell Line; Cluster Analysis; Cyclosporine; Gene Expression Profiling; Gene Expression Regulation; Genomics; Hep G2 Cells; Hepatocytes; Humans; Male; Mice; Primary Cell Culture; Proteome; Proteomics	2013
Evaluation of three-dimensional cultured HepG2 cells in a nano culture plate system: an in vitro human model of acetaminophen hepatotoxicity. Journal of pharmacological sciences, 2014, Volume: 124, Issue:2 Topics: Acetaminophen; Acetylcysteine; Anthracenes; Cells, Cultured; Cyclosporine; Cytochrome P-450 CYP2E1; Drug Evaluation, Preclinical; Glutathione; Hep G2 Cells; Humans; Liver; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Nanotechnology; Toxicity Tests	2014
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen. Toxicology letters, 2015, Jan-22, Volume: 232, Issue:2 Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cyclosporine; Embryo, Nonmammalian; Gene Expression; Hepatocytes; Humans; Immunosuppressive Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Rats; Transcriptome; Zebrafish	2015
Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 150, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Mitochondria, Liver	2016
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices. Chemical research in toxicology, 2016, Mar-21, Volume: 29, Issue:3 Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis; Colchicine; Cyclosporine; Diethylnitrosamine; Drug-Related Side Effects and Adverse Reactions; Ethinyl Estradiol; Female; Gene Expression Profiling; Hepatocytes; Humans; Liver; Male; Methyltestosterone; Middle Aged; Necrosis; Phenotype; Toxicogenetics; Young Adult	2016
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice. Ultrastructural pathology, 2021, Jan-02, Volume: 45, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Liver; Mice	2021
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment. Archives of toxicology, 2021, Volume: 95, Issue:12 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Datasets as Topic; Endoplasmic Reticulum Stress; Gene Expression Profiling; Gene Regulatory Networks; Hepatocytes; Humans; Oxidative Stress; Rats; Risk Assessment; Species Specificity; Toxicogenetics; Tunicamycin	2021