acetaminophen and clofibrate

acetaminophen has been researched along with clofibrate in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (8.33)	18.7374
1990's	5 (13.89)	18.2507
2000's	15 (41.67)	29.6817
2010's	13 (36.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Calder, IC; Nicholls-Grzemski, FA; Priestly, BG	1
Flower, R; Gryglewski, R; Herbaczyńska-Cedro, K; Vane, JR	1
Vargaftig, BB; Zirinis, P	1
Miller, M; Moses, AM	1
Cohen, SD; Hart, SG; Hoivik, DJ; Khairallah, EA; Manautou, JE; Tveit, A	1
Cohen, SD; Emeigh Hart, SG; Khairallah, EA; Manautou, JE	1
Cohen, SD; Hoivik, DJ; Khairallah, EA; Manautou, JE; Tveit, A	1
Carbone, JM; Chen, C; Hennig, GE; Manautou, JE; Nguyen, KA; Silva, VM; Whiteley, HE	1
Burcham, PC; Calder, IC; Nicholls-Grzemski, FA; Priestly, BG	1
Mehendale, HM	1
Chen, C; Corton, JC; Hennig, GE; Manautou, JE; Whiteley, HE	1
Cunningham, MJ; Fuhrman, S; Liang, S; Seilhamer, JJ; Somogyi, R	1
Chen, C; Hennig, GE; Manautou, JE; McCann, DJ	1
Chen, C; Hennig, GE; Manautou, JE; Whiteley, HE	1
Aleksunes, LM; Kardas, MJ; Klaassen, CD; Manautou, JE; Moffit, JS; Slitt, AL	1
Beger, RD; Holland, RD; Koza-Taylor, PH; Lawton, MP; Manautou, JE; Moffit, JS; Thibodeau, MS	1
Fukuyama, T; Ikari, A; Ikushiro, S; Miwa, M; Osabe, M; Sugatani, J	1
Hirabayashi, Y; Horii, I; Inoue, T; Kobayashi, K; Matsushita, T; Suzuki, H	1
Bhave, VS; Donthamsetty, S; Latendresse, JR; Mehendale, HM; Mitra, MS	1
Ando, Y; Kiyosawa, N; Manabe, S; Niino, N; Watanabe, K; Yamoto, T	1
Eghbal, MA; Garjani, A; Ghaffarzadeh, M; Hamzeiy, H; Heidari, R; Nafisi, S; Ziaee, M	1
Chasson, L; Ferreira, DW; Galland, F; Goedken, MJ; Manautou, JE; Naquet, P; Rommelaere, S	1

Reviews

4 review(s) available for acetaminophen and clofibrate

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced dilutional hyponatremia. The New England journal of medicine, 1974, Dec-05, Volume: 291, Issue:23 Topics: Acetaminophen; Amitriptyline; Animals; Anura; Body Fluids; Carbamazepine; Chlorpropamide; Clofibrate; Cyclophosphamide; Diabetes Insipidus; Diabetes Mellitus; Diazoxide; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycemic Agents; Hyponatremia; Kidney; Rats; Sodium; Sulfonylurea Compounds; Tolbutamide; Urinary Bladder; Vasopressins; Vincristine; Water Intoxication; Water-Electrolyte Balance	1974
PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate. Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 57, Issue:2 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Drug Resistance; Hypolipidemic Agents; Liver; Mice; Peroxisome Proliferators; Peroxisomes; Rats; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2000

Other Studies

32 other study(ies) available for acetaminophen and clofibrate

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Peroxisome proliferators protect against paracetamol hepatotoxicity in mice. Biochemical pharmacology, 1992, Apr-01, Volume: 43, Issue:7 Topics: 2,4,5-Trichlorophenoxyacetic Acid; Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Clofibrate; Diethylhexyl Phthalate; Glutathione; Imines; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Male; Mice; Microbodies; Oxidation-Reduction	1992
Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature: New biology, 1972, Jul-26, Volume: 238, Issue:82 Topics: Acetaminophen; Aldosterone; Animals; Anti-Inflammatory Agents; Aspirin; Azathioprine; Benzoates; Biological Assay; Clofibrate; Dexamethasone; Dogs; Edema; Fludrocortisone; Hydrocortisone; In Vitro Techniques; Indomethacin; Mefenamic Acid; Oxygenases; Phenylbutazone; Prostaglandins; Rats; Spleen; Triamcinolone Acetonide	1972
Platelet aggregation induced by arachidonic acid is accompanied by release of potential inflammatory mediators distinct from PGE2 and PGF2. Nature: New biology, 1973, Jul-25, Volume: 244, Issue:134 Topics: Acetaminophen; Anti-Inflammatory Agents; Aorta; Arachidonic Acids; Aspirin; Biological Assay; Blood Platelets; Clofibrate; Glycerol; Indomethacin; Inflammation; Phenylbutazone; Platelet Adhesiveness; Prostaglandins; Tissue Extracts; Vasoconstrictor Agents	1973
Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity. Toxicology and applied pharmacology, 1994, Volume: 129, Issue:2 Topics: Acetaminophen; Analysis of Variance; Animals; Blotting, Western; Carrier Proteins; Clofibrate; Cytochrome P-450 Enzyme System; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Microbodies; Necrosis; Protein Binding; Sulfhydryl Compounds	1994
Protection against acetaminophen hepatotoxicity by a single dose of clofibrate: effects on selective protein arylation and glutathione depletion. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1996, Volume: 29, Issue:2 Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Clofibrate; Corn Oil; Cytosol; Glutathione; Hypolipidemic Agents; L-Iditol 2-Dehydrogenase; Liver; Liver Cirrhosis, Experimental; Male; Mice; Proteins; Staining and Labeling; Sulfhydryl Compounds	1996
Protection by clofibrate against acetaminophen hepatotoxicity in male CD-1 mice is associated with an early increase in biliary concentration of acetaminophen-glutathione adducts. Toxicology and applied pharmacology, 1996, Volume: 140, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biliary Tract; Chromatography, High Pressure Liquid; Clofibrate; Glutamate-Cysteine Ligase; Glutathione; Hypolipidemic Agents; Male; Mice; Microsomes, Liver; Sulfhydryl Compounds	1996
The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice. Journal of toxicology and environmental health. Part A, 1999, Oct-15, Volume: 58, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anticholesteremic Agents; Biotransformation; Blotting, Western; Chemical and Drug Induced Liver Injury; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Docosahexaenoic Acids; Glucuronates; Liver; Liver Function Tests; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Palmitoyl Coenzyme A; Receptors, Cytoplasmic and Nuclear; Succinate Dehydrogenase; Sulfhydryl Compounds; Transcription Factors	1999
Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis. Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 56, Issue:1 Topics: Acetaminophen; Animals; Antidotes; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Clofibrate; Dose-Response Relationship, Drug; Drug Antagonism; Glutathione; Homeostasis; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Male; Maleates; Mice; Peroxisome Proliferators	2000
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure. Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 57, Issue:2 Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Female; Glutathione; Homozygote; Hypolipidemic Agents; Immunoenzyme Techniques; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; Liver; Mice; Mice, Knockout; Necrosis; Organ Size; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2000
Gene expression microarray data analysis for toxicology profiling. Annals of the New York Academy of Sciences, 2000, Volume: 919 Topics: Acetaminophen; Animals; Benzo(a)pyrene; Clofibrate; Drug-Related Side Effects and Adverse Reactions; Entropy; Gene Expression; Gene Expression Profiling; Liver; Male; Oligonucleotide Array Sequence Analysis; Organ Size; Rats; Rats, Sprague-Dawley; RNA, Messenger; Toxicity Tests	2000
Effects of clofibrate and indocyanine green on the hepatobiliary disposition of acetaminophen and its metabolites in male CD-1 mice. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:11 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anions; Anticholesteremic Agents; Bile Ducts; Chromatography, High Pressure Liquid; Clofibrate; Coloring Agents; Drug Interactions; Glucuronides; Indocyanine Green; Liver; Male; Mice; Time Factors	2000
Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction. Journal of biochemical and molecular toxicology, 2002, Volume: 16, Issue:5 Topics: Acetaminophen; Administration, Oral; Amitrole; Analgesics, Non-Narcotic; Animals; Bile; Catalase; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Clofibrate; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Liver; Mice; Mice, Inbred ICR; Necrosis; Peroxisome Proliferators	2002
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology, 2007, Feb-12, Volume: 230, Issue:2-3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Blotting, Western; Chemical and Drug Induced Liver Injury; Clofibrate; Drug Interactions; Enzyme Inhibitors; Hepatocytes; Imines; Indolequinones; L-Lactate Dehydrogenase; Male; Mice; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Peroxisome Proliferators	2007
Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate. Toxicology and applied pharmacology, 2007, Jul-15, Volume: 222, Issue:2 Topics: Acetaminophen; Acyl-CoA Oxidase; Amidohydrolases; Animals; Anticholesteremic Agents; Cell Adhesion Molecules; Chemical and Drug Induced Liver Injury; Clofibrate; Cluster Analysis; Cystamine; Cysteamine; Enoyl-CoA Hydratase; Gene Expression Profiling; GPI-Linked Proteins; Liver; Liver Diseases; Malate Dehydrogenase; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Pantetheine; Pantothenic Acid; Peroxisome Proliferators; PPAR alpha; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction	2007
Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2 Topics: Acetaminophen; Animals; Clofibrate; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Dietary Fats; Dietary Sucrose; Female; Glucuronosyltransferase; Jejunum; Liver; Male; Microsomes, Liver; Organic Anion Transporters; Phenanthrolines; Phenobarbital; PPAR alpha; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors	2008
In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes. Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:2 Topics: Acetaminophen; Animals; Cell Culture Techniques; Cells, Cultured; Clofibrate; Cluster Analysis; Dose-Response Relationship, Drug; Feasibility Studies; Gene Expression Profiling; Hepatocytes; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Toxicity Tests; Transcription, Genetic	2008
Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. Toxicology and applied pharmacology, 2008, Aug-01, Volume: 230, Issue:3 Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Clofibrate; Cytochrome P-450 CYP2E1; Cytoprotection; DNA Replication; Fatty Liver; Liver; Male; Mice; Oxidative Stress; PPAR alpha; Proliferating Cell Nuclear Antigen	2008
Scoring multiple toxicological endpoints using a toxicogenomic database. Toxicology letters, 2009, Jul-24, Volume: 188, Issue:2 Topics: 2-Acetylaminofluorene; Acetaminophen; Algorithms; Animals; Biomarkers; Clofibrate; Data Interpretation, Statistical; Databases, Genetic; Endpoint Determination; Gene Expression; Liver; Male; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Toxicity Tests; Toxicogenetics	2009
Cytoprotective effects of silafibrate, a newly-synthesised siliconated derivative of clofibrate, against acetaminophen-induced toxicity in isolated rat hepatocytes. Arhiv za higijenu rada i toksikologiju, 2014, Volume: 65, Issue:2 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Clofibrate; Cytoprotection; Hepatocytes; Male; Rats; Rats, Sprague-Dawley	2014
Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses. Biochimica et biophysica acta, 2016, Volume: 1862, Issue:4 Topics: Acetaminophen; Amidohydrolases; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Clofibrate; Gene Expression Regulation; GPI-Linked Proteins; Hepatocytes; Liver; Macrophages; Mice; Mice, Knockout; PPAR alpha	2016