acetaminophen and cimetidine

acetaminophen has been researched along with cimetidine in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (39.56)	18.7374
1990's	15 (16.48)	18.2507
2000's	21 (23.08)	29.6817
2010's	18 (19.78)	24.3611
2020's	1 (1.10)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Chang, TK; Ensom, MH; Kiang, TK	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Burkhart, KK; Donovan, JW	1
Bantle, JA; Fort, DJ; Rayburn, JR	1
Fox, MJ; Frank, WO; Nambi, P; Palmer, RH; Wetherington, JD	1
Lewis, RK; Paloucek, FP	1
Hurwitz, A; Parkinson, A	1
Marcuard, SP; Rolband, GC	1
Amor, B; Awada, H; Baetz, A; Chevalier, X	1
Eddy, AC; Kalhorn, TF; Kharasch, ED; McRorie, TI; Reynolds, R; Slattery, JT	1
Franklin, MR; Galinsky, RE; Kane, RE; Lamott, J	1
Bianchine, JR; Gerber, MC; Gerber, N; Tejwani, GA	1
McCormack, JJ; Tong, WP; Webster, LK	1
Hernandez Avila, M; Jick, H; Perera, DR; Romieu, I; Spiegelman, DL; Walker, AM	1
Dent, JG; Gale, KC; Leonard, TB; Newton, JF; Rogers, SA	1
Donovan, JW	1
Speeg, KV	1
Fisher, R; Kadri, AZ; Winterton, MC	1
Davis, M	1
Albano, O; Altomare, E; Leandro, G; Manghisi, OG; Trizio, T; Vendemiale, G	1
Hazama, H; Murase, T; Okuno, H; Sameshima, Y; Shiozaki, Y	1
Greenblatt, DJ; Harmatz, JS; Matlis, R; Scavone, JM	1
Chenery, RJ; Emery, S; Norman, SJ; Oldham, HG	1
Chen, MM; Lee, CS	1
Maldonado, AL; Mitchell, MC; Speeg, KV	1
Kolts, BE; Langfitt, M	1
Critchley, JA; Dyson, EH; Jarvie, DR; Prescott, LF; Scott, AW	1
Mitchell, MC; Schenker, S; Speeg, KV	1
Dent, JG; Leonard, TB	1
Greene, W	1
Bigelow, SW; Lazarte, RA; Levitt, RC; Nebert, DW	1
Attwood, J; Birkett, DJ; Miners, JO	1
Birkett, DJ; Drew, R; Miners, JO	1
D'Arcy, PF	1
Abernethy, DR; Ameer, B; Divoll, M; Greenblatt, DJ; Shader, RI	1
Knodell, RG; Lindemann, NJ; Peterson, FJ; Steele, NM	1
Kern, F; Mallory, A	1
Jackson, JE	2
Ruffalo, RL; Thompson, JF	1
Galinsky, RE; Kaysen, GA; Levy, G; Menke, DJ; Pond, SM; Roberts, SM; Tong, TG	1
Donn, KH; Grisham, JW; Rudd, GD	1
Avant, GR; Mitchell, MC; Schenker, S; Speeg, KV	1
Ivey, KJ	1
Burkhart, KK; Janco, N; Kulig, KW; Rumack, BH	1
Dalhoff, K; Poulsen, HE	1
Abdul-Cader, Z; Al-Ali, AK; Al-Mustafa, ZH; Qaw, FS	1
Kaufenberg, AJ; Shepherd, MF	1
Jennis, T; Lu, HC; Marcus, S; Ruck, B; Shih, RD	1
Dressman, JB; Eleftheriou, G; Macheras, P; Reppas, C; Symillides, M	1
Graf, E; Nada, AH	1
Krenzelok, EP; Zed, PJ	1
Bakos, A; Hazai, E; Monostory, K; Vereczkey, L; Zacher, G	1
Hazai, E; Monostory, K; Vereczkey, L	1
Keleb, EI; Remon, JP; Vermeire, A; Vervaet, C	1
Choi, K; Jung, J; Kim, PG; Kim, Y; Park, J; Park, S	1
Gonnissen, Y; Peeters, E; Remon, JP; Verhoeven, E; Vervaet, C	1
Chang, CY; Martin, P; Tan, HH	1
Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A	1
Miller, GP	1
Kühne, S; Steinert, M; Untucht, C; Wätzig, H	1
Chi, YC; Chiang, CP; Lai, CL; Lee, SL; Lee, SP; Lee, YP; Yin, SJ	1
Freeman, WE; Mullins, ME; Yeager, LH	1

Reviews

12 review(s) available for acetaminophen and cimetidine

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Assessment and treatment of acetaminophen overdose. Clinical pharmacy, 1991, Volume: 10, Issue:10 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Gastric Lavage; Humans; Ipecac	1991
Omeprazole and the induction of human cytochrome P-450: a response to concerns about potential adverse effects. Gastroenterology, 1991, Volume: 100, Issue:4 Topics: Acetaminophen; Carcinogens; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Omeprazole; Phenacetin	1991
Drug interactions with cimetidine: an update. Pharmacology & therapeutics, 1985, Volume: 27, Issue:3 Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Aspirin; Aziridines; Benzodiazepines; Benzoquinones; Cimetidine; Drug Interactions; Humans; Ibuprofen; Imipramine; Kinetics; Lidocaine; Liver Circulation; Pituitary Gland; Procaine; Xanthines	1985
Potential use of cimetidine for treatment of acetaminophen overdose. Pharmacotherapy, 1987, Volume: 7, Issue:6 Pt 2 Topics: Acetaminophen; Animals; Cimetidine; Humans	1987
Protective agents for acetaminophen overdose. Seminars in liver disease, 1986, Volume: 6, Issue:2 Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimetidine; Cysteamine; Glucuronates; Glutathione; Humans; Inactivation, Metabolic; Lipid Peroxides; Liver; Methionine; Necrosis; Propylthiouracil	1986
Drug interactions involving cimetidine--mechanisms, documentation, implications. Quarterly reviews on drug metabolism and drug interactions, 1984, Volume: 5, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12	1984
Drug-induced pancreatitis: a critical review. Gastroenterology, 1980, Volume: 78, Issue:4 Topics: Acetaminophen; Adrenal Cortex Hormones; Amphetamines; Asparaginase; Azathioprine; Chlorthalidone; Cholestyramine Resin; Cimetidine; Cyproheptadine; Dextropropoxyphene; Diazoxide; Diuretics; Estrogens; Ethacrynic Acid; Furosemide; Histamine; Humans; Hypercalcemia; Indomethacin; Isoniazid; Mercaptopurine; Narcotics; Pancreatitis; Phenformin; Procainamide; Rifampin; Salicylates; Sodium Chloride Symporter Inhibitors; Sulfonamides; Tetracycline	1980
Treatment of acetaminophen overdose. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Jun-01, Volume: 56, Issue:11 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anti-Ulcer Agents; Antidotes; Charcoal; Child; Cimetidine; Drug Overdose; Female; Humans; Pregnancy; Time Factors	1999
[About paracetamol again]. Orvosi hetilap, 2001, Feb-18, Volume: 142, Issue:7 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Cimetidine; Drug Overdose; Humans; Liver; Liver Failure, Acute	2001
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review. Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12 Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; Fomepizole; Humans; Mitochondria; Pyridoxal Phosphate	2020

Trials

2 trial(s) available for acetaminophen and cimetidine

Article	Year
Cimetidine--acetaminophen interaction in humans. Journal of clinical pharmacology, 1985, Volume: 25, Issue:3 Topics: Acetaminophen; Adult; Cimetidine; Drug Interactions; Half-Life; Humans; Kinetics; Male	1985
Is there a place for cimetidine or ethanol in the treatment of paracetamol poisoning? Lancet (London, England), 1983, Jun-18, Volume: 1, Issue:8338 Topics: Acetaminophen; Adult; Cimetidine; Ethanol; Guanidines; Humans; Liver; Male	1983

Other Studies

77 other study(ies) available for acetaminophen and cimetidine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Determination of log D via automated microfluidic liquid-liquid extraction. Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16 Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
N-acetylcysteine in treatment of acetaminophen overdose. Journal of clinical gastroenterology, 1992, Volume: 15, Issue:2 Topics: Acetaminophen; Acetylcysteine; Cimetidine; Drug Overdose; Drug Therapy, Combination; Humans	1992
Evaluation of acetaminophen-induced developmental toxicity using FETAX. Drug and chemical toxicology, 1992, Volume: 15, Issue:4 Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Biological Assay; Biotransformation; Carbon Monoxide; Cimetidine; Ellipticines; Glutathione; Male; Rats; Rats, Sprague-Dawley; Species Specificity; Xenopus	1992
Effects of various concomitant medications on gastric alcohol dehydrogenase and the first-pass metabolism of ethanol. The American journal of gastroenterology, 1991, Volume: 86, Issue:12 Topics: Acetaminophen; Adult; Alcohol Dehydrogenase; Animals; Cimetidine; Ethacrynic Acid; Ethanol; Female; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; Nizatidine; Propranolol; Ranitidine; Rats; Reference Values; Salicylates; Salicylic Acid	1991
Cimetidine in the treatment of acetaminophen overdose. Journal of clinical gastroenterology, 1991, Volume: 13, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Cimetidine; Drug Overdose; Drug Therapy, Combination; Female; Humans	1991
Danazol induced pancreatitis and hepatitis. Clinical rheumatology, 1990, Volume: 9, Issue:2 Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cimetidine; Danazol; Female; Humans; Lupus Erythematosus, Systemic; Pancreatitis; Pregnadienes	1990
Lack of effect of cimetidine on acetaminophen disposition in humans. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adult; Cimetidine; Female; Glutathione; Humans; Least-Squares Analysis; Liver; Male	1989
Perinatal cimetidine exposure has no apparent effect on hepatic drug oxidative or conjugative activity in adult male rat offspring. Developmental pharmacology and therapeutics, 1989, Volume: 12, Issue:2 Topics: Acetaminophen; Animals; Arylsulfotransferase; Biotransformation; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cimetidine; Female; Liver; Male; Oxidation-Reduction; Pregnancy; Rats; Rats, Inbred Strains	1989
H2 receptor antagonists, cytochrome P450, and paracetamol-induced hepatotoxicity. Lancet (London, England), 1985, Oct-19, Volume: 2, Issue:8460 Topics: Acetaminophen; Animals; Cimetidine; Cytochrome P-450 Enzyme System; Humans; Liver; Mice; Ranitidine; Rats	1985
Effect of trimethoprim, paracetamol and cimetidine on trimetrexate metabolism by rat perfused isolated livers. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:11 Topics: Acetaminophen; Animals; Cimetidine; Drug Interactions; Folic Acid Antagonists; In Vitro Techniques; Liver; Male; Quinazolines; Rats; Rats, Inbred Strains; Trimethoprim; Trimetrexate	1987
Choice of non-steroidal anti-inflammatory drug in persons treated for dyspepsia. Lancet (London, England), 1988, Sep-03, Volume: 2, Issue:8610 Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cimetidine; Drug Therapy, Combination; Dyspepsia; Female; Health Maintenance Organizations; Humans; Male; Peptic Ulcer	1988
Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Animals; Cimetidine; Drug Synergism; Glucuronates; Glucuronosyltransferase; Liver; Male; Ranitidine; Rats; Rats, Inbred F344	1988
Hepatotoxic and hepatoprotective potential of histamine (H2)-receptor antagonists. The American journal of medicine, 1988, Volume: 85, Issue:6 Topics: Acetaminophen; Acetylcysteine; Animals; Cimetidine; Humans; Liver	1988
Cimetidine and paracetamol hepatotoxicity. Human toxicology, 1988, Volume: 7, Issue:2 Topics: Acetaminophen; Cimetidine; Female; Humans; Liver; Middle Aged	1988
Effect of acute and chronic cimetidine administration on acetaminophen metabolism in humans. The American journal of gastroenterology, 1987, Volume: 82, Issue:10 Topics: Acetaminophen; Administration, Oral; Adult; Cimetidine; Drug Evaluation; Drug Interactions; Duodenal Ulcer; Female; Humans; Male; Methods; Middle Aged	1987
Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury. Japanese journal of pharmacology, 1986, Volume: 41, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Famotidine; Glutathione; Liver; Liver Diseases; Male; Methylcholanthrene; Microsomes, Liver; Ranitidine; Rats; Thiazoles	1986
Interaction of oxaprozin with acetaminophen, cimetidine, and ranitidine. European journal of clinical pharmacology, 1986, Volume: 31, Issue:3 Topics: Acetaminophen; Administration, Oral; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Interactions; Drug Therapy, Combination; Humans; Kinetics; Male; Middle Aged; Oxaprozin; Propionates; Ranitidine; Regression Analysis	1986
The effect of cimetidine and ranitidine on paracetamol glucuronidation and sulphation in cultured rat hepatocytes. Biochemical pharmacology, 1985, May-01, Volume: 34, Issue:9 Topics: Acetaminophen; Animals; Cell Survival; Cells, Cultured; Cimetidine; Glucuronates; Glutathione; Liver; Male; Ranitidine; Rats; Rats, Inbred Strains; Sulfates	1985
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Imines; Liver; Male; Necrosis; Rats; Rats, Inbred F344	1985
Drugs and the liver. Comprehensive therapy, 1984, Volume: 10, Issue:12 Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil	1984
Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man. The Journal of clinical investigation, 1984, Volume: 73, Issue:2 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Glucuronates; Glutathione; Histamine H2 Antagonists; Humans; Kinetics; Liver; Lymphocytes; Male; Metabolic Clearance Rate; Microsomes, Liver; Oxidation-Reduction; Protein Binding; Rats; Rats, Inbred F344	1984
Effects of H2 receptor antagonists on the hepatotoxicity of various chemicals. Research communications in chemical pathology and pharmacology, 1984, Volume: 44, Issue:3 Topics: 1-Propanol; Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Cimetidine; Drug Antagonism; Drug Synergism; Histamine H2 Antagonists; Imidazoles; Liver; Male; Propanols; Pyrimidinones; Ranitidine; Rats; Rats, Inbred F344	1984
Effects of cimetidine on theophylline, acetaminophen, and zoxazolamine toxicity in the intact mouse. Developmental pharmacology and therapeutics, 1984, Volume: 7, Issue:1 Topics: Acetaminophen; Animals; Cimetidine; Cytochrome P-450 Enzyme System; Female; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Theophylline; Zoxazolamine	1984
Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:4 Topics: Acetaminophen; Administration, Oral; Adult; Anticonvulsants; Biotransformation; Cimetidine; Drug Interactions; Epilepsy; Humans; Kinetics; Male; Smoking; Sulfinpyrazone	1984
Effect of cimetidine on paracetamol activation in mice. Biochemical pharmacology, 1984, Jun-15, Volume: 33, Issue:12 Topics: Acetaminophen; Alanine Transaminase; Animals; Biotransformation; Cimetidine; Glutathione; Male; Mice; Mice, Inbred C3H; Piperonyl Butoxide	1984
Early reports on drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine	1983
Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3 Topics: Acetaminophen; Adult; Animals; Antipyrine; Biotransformation; Cimetidine; Diazepam; Guanidines; Humans; Kinetics; Lethal Dose 50; Lorazepam; Male; Mice; Oxidation-Reduction	1983
Prevention of acetaminophen and cocaine hepatotoxicity in mice by cimetidine treatment. Gastroenterology, 1983, Volume: 85, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Cocaine; Cytochrome P-450 Enzyme System; Guanidines; Kinetics; Liver; Male; Mice; Premedication	1983
Cimetidine protects against acetaminophen toxicity. Life sciences, 1982, Jul-05, Volume: 31, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Animals; Cimetidine; Female; Guanidines; Humans; Liver; Male; Mice; Mice, Inbred Strains	1982
Cimetidine and acetylcysteine as antidote for acetaminophen overdose. Southern medical journal, 1982, Volume: 75, Issue:8 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Therapy, Combination; Guanidines; Humans; Liver Diseases; Time Factors	1982
Massive intoxication with acetaminophen and propoxyphene: unexpected survival and unusual pharmacokinetics of acetaminophen. Journal of toxicology. Clinical toxicology, 1982, Volume: 19, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Cimetidine; Dextropropoxyphene; Female; Humans; Kinetics; Lethal Dose 50; Male; Mice; Renal Dialysis; Time Factors	1982
Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice. Research communications in chemical pathology and pharmacology, 1981, Volume: 32, Issue:2 Topics: Acetaminophen; Animals; Cimetidine; Female; Guanidines; Liver; Mice; Necrosis	1981
Cimetidine protects against acetaminophen hepatotoxicity in rats. Gastroenterology, 1981, Volume: 81, Issue:6 Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cimetidine; Glutathione; Guanidines; Liver; Liver Diseases; Male; Microsomes, Liver; Necrosis; Rats; Rats, Inbred F344	1981
Cimetidine protects against acetaminophen hepatoxicity. Veterinary and human toxicology, 1981, Volume: 23, Issue:Suppl 1 Topics: Acetaminophen; Adolescent; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Guanidines; Half-Life; Humans; Liver Diseases; Male; Mice	1981
Drugs, gastritis, and peptic ulcer. Journal of clinical gastroenterology, 1981, Volume: 3, Issue:Suppl 2 Topics: Acetaminophen; Animals; Aspirin; Bicarbonates; Cimetidine; Duodenitis; Gastric Acid; Gastric Mucosa; Gastritis; Humans; Hydrogen-Ion Concentration; Indomethacin; Intestinal Mucosa; Peptic Ulcer; Prostaglandins; Rats; Tablets, Enteric-Coated	1981
Cimetidine as adjunctive treatment for acetaminophen overdose. Human & experimental toxicology, 1995, Volume: 14, Issue:3 Topics: Acetaminophen; Adult; Cimetidine; Drug Overdose; Female; Humans; Liver Diseases; Male	1995
Inhibition of acetaminophen oxidation by cimetidine and the effects on glutathione and activated sulphate synthesis rates. Pharmacology & toxicology, 1993, Volume: 73, Issue:4 Topics: Acetaminophen; Animals; Cells, Cultured; Cimetidine; Cytochrome P-450 Enzyme System; Female; Glutathione; Liver; Oxidation-Reduction; Phosphoadenosine Phosphosulfate; Rats; Rats, Wistar	1993
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol. Toxicology, 1997, Sep-05, Volume: 121, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Cimetidine; Free Radical Scavengers; Glutathione; Histamine H2 Antagonists; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Necrosis; Survival Rate	1997
Role of cimetidine in the treatment of acetaminophen poisoning. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Jul-15, Volume: 55, Issue:14 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Humans; Liver Diseases	1998
Pseudomethemoglobinemia: a case report and review of sulfhemoglobinemia. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:8 Topics: Acetaminophen; Adolescent; Cimetidine; Diagnosis, Differential; Female; Humans; Ibuprofen; Methemoglobinemia; Naproxen; Oximetry; Suicide, Attempted; Sulfhemoglobinemia	1998
Effect of elevated viscosity in the upper gastrointestinal tract on drug absorption in dogs. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1998, Volume: 6, Issue:2 Topics: Acetaminophen; Animals; Area Under Curve; Chemistry, Pharmaceutical; Cimetidine; Dogs; Female; Galactans; Gastric Emptying; Hydrochlorothiazide; Intestinal Absorption; Mannans; Mefenamic Acid; Pharmacokinetics; Plant Gums; Viscosity	1998
Evaluation of Vitacel M80K as a new direct compressible vehicle. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 1998, Volume: 46, Issue:3 Topics: Acetaminophen; Ascorbic Acid; Cellulose; Cimetidine; Compressive Strength; Evaluation Studies as Topic; Particle Size; Pharmaceutical Vehicles; Powders; Surface Properties; Tablets	1998
Reduction of toxic metabolite formation of acetaminophen. Biochemical and biophysical research communications, 2002, Mar-08, Volume: 291, Issue:4 Topics: Acetaminophen; Analgesics, Non-Narcotic; Benzoquinones; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Enzyme Inhibitors; Fomepizole; Humans; Imines; Microsomes, Liver; Pyrazoles	2002
Extrusion granulation and high shear granulation of different grades of lactose and highly dosed drugs: a comparative study. Drug development and industrial pharmacy, 2004, Volume: 30, Issue:6 Topics: Acetaminophen; Chemistry, Pharmaceutical; Cimetidine; Drug Compounding; Drug Stability; Excipients; Lactose; Particle Size; Pharmaceutical Preparations; Povidone; Powders; Shear Strength; Tablets; Tensile Strength; Time Factors	2004
Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environment international, 2007, Volume: 33, Issue:3 Topics: Acetaminophen; Aliivibrio fischeri; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Carbamazepine; Cimetidine; Daphnia; Diltiazem; Environmental Monitoring; Histamine H2 Antagonists; Korea; Lethal Dose 50; Oryzias; Quantitative Structure-Activity Relationship; Risk Assessment; Sulfonamides; Water Pollutants, Chemical	2007
Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2008, Volume: 69, Issue:1 Topics: Acetaminophen; Carbohydrates; Chemistry, Pharmaceutical; Cimetidine; Desiccation; Dosage Forms; Drug Compounding; Ibuprofen; Microscopy, Electron, Scanning; Models, Statistical; Particle Size; Povidone; Powders; Solubility; Technology, Pharmaceutical; X-Ray Diffraction	2008
Acetaminophen hepatotoxicity: current management. The Mount Sinai journal of medicine, New York, 2009, Volume: 76, Issue:1 Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Cimetidine; Comorbidity; Disease Progression; Drug and Narcotic Control; Free Radical Scavengers; Humans; Liver Failure; Liver Transplantation; Prognosis; Renal Dialysis; Severity of Illness Index; Treatment Outcome	2009
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:5 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Liver; Magnetic Resonance Spectroscopy; Male; Rabbits; Silybin; Silymarin	2009
Warfarin therapy: how the less interesting half just got interesting. Journal of thrombosis and haemostasis : JTH, 2010, Volume: 8, Issue:12 Topics: Acetaminophen; Anticoagulants; Azithromycin; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Gefitinib; Humans; Omeprazole; Quinazolines; Stereoisomerism; Substrate Specificity; Warfarin	2010
Fast investigations from biological matrices using CE--test of a blood-brain barrier model. Electrophoresis, 2012, Volume: 33, Issue:2 Topics: Acetaminophen; Adsorption; Animals; Blood-Brain Barrier; Caffeine; Carbamazepine; Cell Culture Techniques; Cell Line; Chromatography, Micellar Electrokinetic Capillary; Cimetidine; Humans; Indomethacin; Limit of Detection; Models, Biological; Propranolol; Rats; Reproducibility of Results; Tissue Distribution	2012
Ethanol oxidation and the inhibition by drugs in human liver, stomach and small intestine: Quantitative assessment with numerical organ modeling of alcohol dehydrogenase isozymes. Chemico-biological interactions, 2016, Oct-25, Volume: 258 Topics: Acetaminophen; Alcohol Dehydrogenase; Aspirin; Cimetidine; Ethanol; Gastric Mucosa; Genotype; Humans; Intestine, Small; Isoenzymes; Kinetics; Liver; Models, Biological; Oxidation-Reduction; Pharmaceutical Preparations; Salicylic Acid; Stomach; Substrate Specificity	2016