acetaminophen has been researched along with carbon tetrachloride in 166 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (19.88) | 18.7374 |
| 1990's | 33 (19.88) | 18.2507 |
| 2000's | 48 (28.92) | 29.6817 |
| 2010's | 43 (25.90) | 24.3611 |
| 2020's | 9 (5.42) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Mitchell, JR; Potter, WZ; Sasame, HA; Thorgeirsson, SS | 1 |
| Hart, FE; Hew, JT; Willson, RA | 1 |
| Ding, Y; Huang, DK; Shen, JP; Zhang, XL; Zhang, YD; Zhu, SH | 1 |
| Awad, JA; Badr, KF; Burk, RF; Kato, T; Morrow, JD; Roberts, LJ; Takahashi, K | 1 |
| Liu, GT | 1 |
| Moore, L; Wright, PB | 1 |
| Eberhardt, I; Lemoine, R; Younes, M | 1 |
| Delaforge, M; Jaouen, M; Jollès, P; Mansuy, D; Migliore-Samour, D | 1 |
| Tsokos-Kuhn, JO | 1 |
| Mason, RP; Morehouse, KM; Stolze, K | 1 |
| Flanagan, RJ; Mant, TG; Ruprah, M | 1 |
| Hughes, H; Mitchell, JR; Smith, CV; Tsokos-Kuhn, JO | 1 |
| Born, CK; Dillehay, DL; Hamrick, ME; Joyave, JL; Steinhauer, LS | 1 |
| Lau, SS; Monks, TJ | 1 |
| Burcham, PC; Harman, AW | 1 |
| Bhatia, A; Sood, SK | 1 |
| Haschek, WM; Jeffery, EH | 1 |
| Bien, E; Witt, M | 1 |
| Farber, JL | 1 |
| Landon, EJ; Naukam, RJ; Rama Sastry, BV | 1 |
| Loeser, W; Siegers, CP | 1 |
| Cho, C; Coulson, R; Linscheer, WG; Raheja, KL | 1 |
| Siegers, CP; Younes, M | 1 |
| Kobayashi, M; Nagashima, H; Nakatsukasa, H; Watanabe, A | 1 |
| Hook, JB; Newton, JF; Rush, GF; Smith, JH | 1 |
| Farber, JL; Gerson, RJ | 1 |
| Bannwarth, B; Debry, G; Royer, RJ; Ulmer, M | 1 |
| Mørland, J; Vonen, B | 1 |
| Chaturvedi, R; Mehrotra, R; Nath, P; Pandey, R | 1 |
| Jess, U; Siegers, CP; Younes, M | 1 |
| Gharaibeh, Ael M; Remmer, H | 1 |
| Hughes, H; Mitchell, JR; Smith, CV | 1 |
| Oltmanns, D; Siegers, CP; Younes, M | 1 |
| Deboyser, D; Goethals, F; Krack, G; Roberfroid, M | 1 |
| Breining, H; Strubelt, O | 1 |
| Lieber, CS | 1 |
| Curzio, M; Flaccavento, C; Primon, A; Tesio, A; Torrielli, MV | 1 |
| Gilani, AH; Janbaz, KH | 4 |
| Hooser, SB; Rosengren, RJ; Sauer, JM; Sipes, IG | 1 |
| Chanda, S; Mehendale, HM | 1 |
| Michael, S; Simko, V | 1 |
| Klaassen, CD; Liu, J; Liu, Y | 1 |
| Raiford, DS; Thigpen, MC | 1 |
| Lin, CC; Lin, SC; Lin, YH; Shyuu, SJ | 1 |
| Allen, RL; Billington, D; Osypiw, JC | 1 |
| Hammock, BD; Huang, TL; Villalobos, SA | 1 |
| Kamiyama, T; Liu, J; Marumo, F; Miyakawa, H; Sato, C; Tajiri, K | 1 |
| Brent, JA; Rumack, BH | 1 |
| Earnest, DL; elSisi, AE; Hall, P; Sim, WL; Sipes, IG | 1 |
| Cederbaum, AI; Dai, Y | 1 |
| Lin, CC; Lin, SC; Lin, YH; Supriyatna, S; Teng, CW | 1 |
| Kauffman, FC; Pang, JM; Zaleski, J | 1 |
| Lin, CC; Lin, SC; Lin, YH; Pan, SL; Supriyatna, S | 1 |
| Akhtar, MS; Gilani, AH; Janbaz, KH | 1 |
| Fariss, MW; Lippman, HR; Mumaw, VR; Ray, SD | 1 |
| Nomura, F; Ohnishi, K | 1 |
| Han, SH; Jeon, YJ; Kaminski, NE; Yang, KH | 1 |
| Lin, CC; Shieh, DE; Yen, MH | 1 |
| Roberts, SM; Salminen, WF; Voellmy, R | 1 |
| Gilani, AH; Janbaz, KH; Shah, BH | 1 |
| Mishra, SH; Rao, KS | 1 |
| Gilani, AH; Janbaz, KH; Saeed, SA | 3 |
| Bucur, N; Puică, C; Rusu, MA; Tămaş, M | 1 |
| Sato, A | 1 |
| Clement, YN; Dodd, CC; Kevin Park, B; Kitteringham, NR; McLellan, LI; Pirmohamed, M; Powell, H; Smith, DA; Tettey, JN | 1 |
| Klaassen, CD; Liu, J; Parkinson, A; Sendelbach, LE | 1 |
| Chen, K; Shih, JC; Yang, M | 1 |
| Chung, TC; Lin, CC; Lin, SC; Lin, SY; Lin, YH; Ueng, TH; Wang, LY | 1 |
| Ansari, SH; Porchezhian, E | 2 |
| Huang, PC; Lin, CC | 1 |
| Johri, RK; Karan, M; Karan, V; Reen, RK; Singh, J; Singh, K | 1 |
| Gonzalez, FJ | 1 |
| Cho, CC; Cho, CH; Lee, SS; Li, Y; Liu, ES; Sheng, HP; So, HL; Ye, YN | 1 |
| Bhattacharyya, P; Datta, S | 1 |
| Kaneko, T; Li, J; Qin, LQ; Sato, A; Wang, PY; Wang, Y | 1 |
| Hsieh, WT; Ko, YJ; Lin, WC; Wu, YW | 1 |
| Greabu, M; Olinescu, R | 1 |
| Apte, UM; Bucci, TJ; Manautou, JE; Mehendale, HM; Ronis, MJ; Shankar, K; Vaidya, VS | 1 |
| Besra, SE; Chakravorty, AK; Das, B; Das, M; Ganguly, DK; Gomes, A; Sur, P; Vedasiromoni, JR | 1 |
| Apte, UM; Bucci, TJ; Limaye, PB; Mehendale, HM; Shankar, K; Warbritton, A | 1 |
| Bhattacharyya, D; Das, N; Mukherjee, R; Pandit, S; Sur, TK | 1 |
| Aleksunes, LM; Cherrington, NJ; Klaassen, CD; Manautou, JE; Slitt, AM; Thibodeau, MS | 1 |
| Farkas, D; Tannenbaum, SR | 1 |
| Kato, H; Katoh, M; Minami, K; Nakajima, M; Narahara, M; Saito, T; Sugiyama, H; Tomita, H; Yokoi, T | 1 |
| Chandan, BK; Prabhakar, A; Qazi, GN; Singh, B; Singh, J; Taneja, SC | 1 |
| Hennig, GE; Manautou, JE; Silva, VM | 1 |
| Aleksunes, LM; Jakowski, AB; Manautou, JE; Pruimboom-Brees, IM; Scheffer, GL | 1 |
| Kim, DH; La, S; Yoo, HH | 1 |
| Jung, YS; Kim, SY; Kim, YC; Yim, HK | 1 |
| Fujikawa, M; Hamada, Y; Horii, I; Kikkawa, R; Yamada, H; Yamamoto, T | 1 |
| Horii, I; Kikkawa, R; Yamada, H; Yamamoto, T | 1 |
| Asad, M; Kamath, JV; Roy, CK | 1 |
| Baheti, JR; Goyal, RK; Shah, GB | 1 |
| Asad, M; Kamath, JV; Y, J | 1 |
| Bhardwaj, V; Chandan, BK; Gupta, BD; Gupta, VN; Satti, NK; Sharma, N; Singh, B; Suri, KA; Suri, OP | 1 |
| Apte, UM; Bhave, VS; Latendresse, JR; Limaye, PB; Mehendale, HM; Palkar, PS; Reddy, JK; Sawant, SP; Yu, S | 1 |
| Izegbu, MC; Yemitan, OK | 1 |
| Chen, W; Chuang, PT; Liu, CT; Tseng, CY; Weng, YM; Wu, CY | 1 |
| Davis, RJ; Flavell, RA; Frew, J; Henderson, NC; Mackinnon, AC; Pollock, KJ; Sethi, T; Simpson, KJ | 1 |
| Fukushima, T; Hamada, Y; Horii, I; Kikkawa, R | 1 |
| Jung, YS; Kim, SY; Kim, YC; Park, JH; Yim, HK | 1 |
| Fukushima, T; Hamada, Y; Horii, I; Yamada, H | 1 |
| Benson, CA; Goldring, CE; Kitteringham, NR; Metcalfe, PN; Park, BK; Randle, LE; Williams, DP | 1 |
| Groben, P; Pisetsky, DS; Tran, TT | 1 |
| Bauerschmidt, S; Draaisma, AL; Elferink, MG; Groothuis, GM; Merema, MT; Olinga, P; Polman, J; Schoonen, WG | 1 |
| Anuja, GI; Krishnakumar, NM; Latha, PG; Pradeep, S; Rajasekharan, S; Shikha, P; Shine, VJ; Shyamal, S; Sini, S; Suja, SR; Unni, PK | 1 |
| Alvarez, M; Culebras, JM; González-Gallego, J; Tuñón, MJ | 1 |
| Das, AK; Roy, CK | 1 |
| Adeneye, AA | 1 |
| Bishayee, A; Darvesh, AS; McGory, R; Politis, T | 1 |
| Firdous, AP; Kuttan, R; Preethi, KC; Sindhu, ER | 1 |
| Balakrishnan, N; Bhaskar, VH | 1 |
| Firdous, AP; Kuttan, R; Sindhu, ER | 1 |
| Davis, K; Greenhaw, J; Mendrick, DL; Qian, F; Salminen, WF; Shi, Q; Su, Z; Yang, X | 1 |
| Chung, BC; Jung, BH; Kumar, BS; Kwon, OS | 1 |
| Honjo, T; Kuribayashi, T; Momotani, E; Seita, T; Yamamoto, S; Yamazaki, S | 1 |
| Daniele, SM; Lardizábal, MN; Nocito, AL; Ornella, LA; Palatnik, JF; Veggi, LM | 1 |
| Krasteva, I; Mitcheva, M; Nikolov, S; Simeonova, R; Vitcheva, V | 1 |
| Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ | 1 |
| Devaraj, VC; Kamath, JV; Krishna, BG; Kumar, S; Viswanatha, GL | 1 |
| Bame, JR; Erez-Roman, R; Futerman, AH; Kogot-Levin, A; Merrill, AH; Park, JW; Park, WJ; Pewzner-Jung, Y; Saada, A; Tirosh, B | 1 |
| Rashid, K; Sil, PC; Sinha, K | 1 |
| Li, W; Pu, XP; Sun, H; Sun, Y; Wang, YH; Yang, YF; Zhao, X; Zheng, XY | 1 |
| Affò, S; Alvarez-Guaita, A; Arroyo, V; Bataller, R; Blaya, D; Caballería, J; Coll, M; Enrich, C; Ginès, P; Lozano, JJ; Maestro, MA; Millán, C; Morales-Ibanez, O; Rentero, C; Rodrigo-Torres, D; Sancho-Bru, P; Solar, M; van Grunsven, LA | 1 |
| Dan, YY; Ho, HK; Lai, RC; Lim, SK; Tan, CY; Wong, W | 1 |
| Aarestrup, BJ; Aarestrup, FM; da Silva Filho, AA; de Sousa, OV; do A Corrêa, JO; Rezende, TP | 1 |
| Ismail, NA; Kamisan, FH; Mamat, SS; Mohd-Desa, MN; Mohtarrudin, N; Shamsahal-Din, NS; Wan Zainulddin, WN; Yahya, F; Zabidi, Z; Zakaria, ZA | 1 |
| Akah, PA; Ihim, SA; Laiyemo, KA; Nworu, CS; Ugwu, LE | 1 |
| Besednova, NN; Kovalev, NN; Kryzhanovskiĭ, SP; Kuznetsova, TA; Zaporozhets, TS; Zviagintseva, TN | 1 |
| Gonzalez, FJ; Ikeda, K; Kawada, N; Krausz, KW; Le, TT; Matsubara, T; Teranishi, Y; Yoshizato, K | 1 |
| Elferink, ML; Groothuis, GM; Olinga, P; Schoonen, WG; Vatakuti, S | 1 |
| Bai, L; Chen, Y; Duan, Z; Ren, F; Zhang, X; Zheng, S; Zu, K | 1 |
| Cheng, M; Liu, X; Liu, Y; Xiao, H | 1 |
| Al Masaoudi, M; Bechmann, LP; Boekschoten, MV; Canbay, AE; Cubero, FJ; Davis, RJ; Gassler, N; Hu, W; Liedtke, C; Luedde, T; Muller, M; Nevzorova, YA; Peng, J; Preisinger, C; Trautwein, C; Zhao, G; Zoubek, ME | 1 |
| Deng, H; Hou, Z; Ju, L; Li, Y; Wang, L; Wang, Y; Xie, J; Zhang, Y; Zhang, Z | 1 |
| Antoine, DJ; Caballero, J; Campbell, D; Glusman, G; Gray, L; Hampson, L; Hood, L; Kim, TK; Kusebauch, U; McEvoy, L; Moritz, RL; Omenn, GS; Park, KB; Pirmohamed, M; Qin, S; Rowen, L; Wang, K; Yan, X; Yuan, Y; Zhou, Y | 1 |
| Asano, T; Fujishiro, M; Fukushima, T; Kaneko, S; Kikuchi, T; Kushiyama, A; Matsunaga, Y; Nakatsu, Y; Sakoda, H; Tokunaga, F; Yamamotoya, T; Yamazaki, H | 1 |
| Baba, HA; Bechmann, LP; Best, J; Bian, CB; Canbay, A; Cubero, FJ; Faber, KN; Fiel, MI; Friedman, SL; Gerken, G; Hernandez-Gea, V; Hoshida, Y; Jafoui, S; Kälsch, J; Manka, P; Moshage, H; Nelson, LJ; Paul, A; Sowa, JP; Sydor, S; Vetter, D; Zoubek, ME | 1 |
| Ji, S; Kuang, Y; Li, K; Lin, Y; Qiao, X; Song, W; Ye, M; Zhang, Q | 1 |
| Arbelaiz, A; Banales, JM; Bujanda, L; Esparza-Baquer, A; Esterbauer, H; Fontanellas, A; Gawish, R; Hijona, E; Jais, A; Jimenez-Agüero, R; Knapp, S; Korosec, A; Labiano, I; Mann, DA; Mann, J; Oakley, F; Perugorria, MJ; Sampedro, A; Santos-Laso, A; Sharif, O; Stoiber, D; Tiniakos, D | 1 |
| Ahsan, H; Asif, H; Khan, IU; Khan, KU; Nasir, Z; Naz, H; Qaisar, MN; Saleem, M; Sharif, A; Uttra, AM; Younis, W | 1 |
| Khan, H; Nabavi, SM; Ullah, H | 1 |
| Abdel-Kawy, HS | 1 |
| Jaeschke, H; McGill, MR | 1 |
| Garcia-Macia, M; Knox, A; Luli, S; Mann, DA; Mann, J; Moran-Salvador, E; Oakley, F; Page, A; Sabater, L; Sivaharan, A; Zaki, MYW | 1 |
| Blais, EM; Dougherty, BV; Kolling, GL; Pannala, VR; Papin, JA; Rawls, KD; Vinnakota, KC; Wallqvist, A | 1 |
| Gao, X; Qu, H; Wang, ZY; Yi, JJ | 1 |
| Abd Eldaim, MA; Abdallah, AEM; Abdel-Daim, MM; Abdelaziz, SAM; Abdul Rashid, S; Abdullah, AS; Abdullah, LC; Abramson, MJ; Ahmed, HB; Ahmed, MM; Ahn, YC; Alexander, DC; Ando, T; Angelone, AM; Anglani, F; Ap, Y; Arthanari, SK; Axelrad, C; Bai, S; Bakonyi, P; Barnes, E; Beckmann, NA; Bélafi-Bakó, K; Bennett, CM; Bestha, RM; Bitsch, RG; Bradley, CA; Bu, Y; Calò, LA; Cañedo-Villaroya, E; Carlson, L; Caruso, S; Casado-Flores, J; Ceol, M; Cesarino, I; Chen, IL; Chen, R; Chen, X; Chilvers, MI; Cho, WK; Choong, TSY; Conceição-Neto, N; Culver, EL; Dai, X; de Lama Caro-Patón, G; De Rosa, I; Del Prete, D; Dharmage, SC; Dimitriadis, E; Dittakavi, S; Dobrowolski, JC; Edin, S; Elgarawany, GE; Emam, HE; Emmens, RW; Erbas, B; Erwich, JJHM; Farghali, M; Feng, L; Funston, RN; Gabler, NK; Gale, P; Ganesh, M; Gao, J; Gao, L; Gao, X; García-Salido, A; Gatto, R; Gautam, S; Ge, C; Ghogomu, SM; Gianesello, L; Gonçales, VR; Gooch, JL; Gooding, JJ; Gourley, GG; Gu, H; Gu, X; Gu, Z; Guerreri, M; Guillén, M; Hazzaa, SM; Heylen, E; Hicks, R; Hong, X; Hoshi, M; Hu, B; Hu, LX; Hu, R; Hu, S; Huang, J; Huang, K; Hubbard, WB; Hui, J; Hwang, NY; Iannacci, J; Ianus, A; Iglesias-Bouzas, MI; Ihara, I; Iwasaki, M; Jaeger, S; Kandel, YR; Karpińska, G; Kim, HK; Klopfenstein, TJ; Knorr, D; Koók, L; Kotb, S; Kruithof, S; Larsson, P; Laurence, C; Leng, J; Li, H; Li, J; Li, Q; Li, S; Li, X; Li, Z; Lian, J; Liang, JX; Liang, X; Lighaam, LC; Lin, CW; Lin, HC; Lin, J; Ling, A; Liu, J; Liu, P; Liu, YS; Ljuslinder, I; Lo, GH; Lodge, CJ; Löfgren-Burström, A; Lowe, AJ; Lu, M; Lu, N; Lucero-Prisno, DE; Luebbe, KM; Luo, X; Ma, Z; Maes, P; Makuch, M; Malekbala, MR; Mao, Z; Martínez-Romera, I; Marzo, G; Mathew, FM; Mattei, A; Matthijnssens, J; Mayumi, M; Morita, N; Mueller, DS; Mullangi, R; Mummolo, S; Murthi, P; Myte, R; Nabeshima, T; Nakamoto, K; Nehdi, IA; Nemestóthy, N; Niessen, HWM; Noh, JM; Nota, A; Nunes, D; Oh, D; Öhlund, D; Olsen, KM; Ono, H; Osawa, Y; Palmqvist, R; Palombo, M; Park, M; Patience, JF; Peng, Y; Perng, DS; Persano, A; Priante, G; Prince, SJ; Pulipati, S; Pyo, H; Qiu, X; Quan, J; Quaranta, F; Quinzi, V; Rademacher, CJ; Rajaraman, G; Rashid, U; Rauch, JC; Rector, A; Remmerswaal, EBM; Ren, R; Rispens, T; Rocha, GS; Saad, NM; Saito, K; Salamova, A; Sarfaraz, K; Satoshi, A; Schnellmann, RG; Scholpa, NE; Schonhoff, M; Schwartz, KJ; Schwarze, M; Schweer, WP; Seiichi, Y; Serrano-González, A; Severino, J; Shemesh, N; Shi, ZQ; Shike, DW; Shim, YM; Siciliano, PA; Siebenrock, KA; Silva, MKL; Smith, DL; Soltani, S; Song, YM; Spry, ML; Stalker, LA; Stokes, RS; Sullivan, PG; Sun, JM; Sun, S; Svanes, C; Syo, K; Tai, CM; Takashima, S; Tashita, C; Taurino, A; Ten Berge, IJM; Tenuta, AU; Teo, SH; Tilley, RD; Trivedi, RK; Umetsu, K; Unger, PA; van Bruggen, R; van Ham, SM; Van Ranst, M; Vanitha, J; Vekaria, HJ; Venier, M; Venkateshwaran, K; Venkert, A; Vermeulen, E; Wan, C; Wang, H; Wang, N; Wang, P; Wang, T; Wang, X; Wang, Y; Wise, KA; Wolbink, GJ; Wu, J; Wu, P; Wu, S; Wu, Y; Xia, Q; Xin, W; Xiong, Q; Xu, H; Xu, P; Xue, S; Yamamoto, Y; Yamashiro, T; Yan, F; Yan, H; Yan, S; Yan, Y; Yang, JM; Yang, L; Yang, P; Ye, W; Yeh, JH; Yinda, CK; Ying, GG; Ying, L; Yoon, HG; Yu, H; Zainuddin, M; Zakkula, A; Zeller, M; Zeng, Y; Zha, J; Zhang, F; Zhang, H; Zhang, M; Zhang, Q; Zhang, S; Zhang, T; Zhang, Z; Zhao, C; Zhao, J; Zhao, Y; Zhong, Q; Zhu, J; Zingmark, C; Zo, JI; Zou, Y | 1 |
| Adams, DH; Bhandari, R; Bourke, S; Chauhan, A; Haldar, D; Hussain, MT; Lalor, PF; Patten, DA; Shaw, R; Shepherd, EL; Sheriff, L; Watson, S; Watson, SP; Webb, GJ; Weston, CJ | 1 |
| Estes, SK; O'Brien, TP; Pannala, VR; Printz, RL; Rahim, M; Reifman, J; Shiota, C; Shiota, M; Trenary, I; Wallqvist, A; Young, JD | 1 |
| Akbar, S; Bushra, R; Ghayas, S; Hussain, K; Ishtiaq, S | 1 |
| Cui, XY; Duan, S; He, JF; Liu, CR; Ma, CM; Shan, CB; Wang, LW; Wang, Y | 1 |
| Arechederra, M; Ávila, MA; Azkona, M; Berasain, C; Bilbao, I; Corrales, FJ; Elizalde, M; Esquivel, A; Fernández-Barrena, MG; Fernandez-Checa, JC; Gárate-Rascón, M; Garcia-Ruiz, C; Jimenez, M; Latasa, MU; Pineda-Lucena, A; Recalde, M; Sangro, B; Uriarte, I; Urtasun, R | 1 |
| Brackhagen, L; Cramer, B; Degen, GH; Friebel, A; Ghallab, A; González, D; Hassan, R; Hengstler, JG; Hobloss, Z; Hoehme, S; Humpf, HU; Marchan, R; Myllys, M; Seddek, AL | 1 |
| Bobrov, N; Elagin, V; Gavrina, A; Karabut, M; Kozlov, D; Krylov, D; Kuznetsova, D; Mozherov, A; Rodimova, S; Shchechkin, I; Zagainov, V; Zagaynova, E | 1 |
16 review(s) available for acetaminophen and carbon tetrachloride
| Article | Year |
|---|---|
Effects of some compounds isolated from Chinese medicinal herbs on hepatic microsomal cytochrome P-450 and their potential biological consequences.
Topics: Acetaminophen; Alkaloids; Animals; Carbon Tetrachloride; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Enzyme Induction; Humans; Isoquinolines; Lignans; Lignin; Liver | 1991 |
Electron spin resonance studies of the free radical metabolites of toxic chemicals.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Liver; Nitrogen Oxides; Porphyrins; Rats | 1987 |
Reactive intermediates and their toxicological significance.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Carbon Tetrachloride; Glucuronates; Glutathione; Humans; Lipid Peroxidation; Sulfates; Xenobiotics | 1988 |
The biochemical pathology of toxic cell death.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Carbon Tetrachloride; Cell Membrane; Cell Membrane Permeability; Cell Survival; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Free Radicals; Humans; Membrane Potentials; Mixed Function Oxygenases; Necrosis; Oxygen | 1985 |
Chemically induced nephrotoxicity: role of metabolic activation.
Topics: Acetaminophen; Animals; Antifungal Agents; Antinematodal Agents; Biotransformation; Bromobenzenes; Butadienes; Carbon Tetrachloride; Cephaloridine; Chloroform; Ethylene Dibromide; Female; Humans; Inactivation, Metabolic; Kidney; Kidney Diseases; Lethal Dose 50; Male; Organophosphates; Propane; Rats; Terpenes | 1984 |
Mechanisms of cell injury with hepatotoxic chemicals.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Lipid Peroxides; Liver; Microsomes, Liver; Mixed Function Oxygenases; Necrosis; Oxygen Consumption | 1984 |
Food and drug interactions.
Topics: Acetaminophen; Antacids; Carbon Tetrachloride; Digestive System; Ethanol; Food; Humans; Intestines; Kinetics; Nitrates; Pharmaceutical Preparations; Solubility | 1984 |
Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver injury?
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Diquat; Ethanol; Free Radicals; Humans; Hydrocarbons, Halogenated; Liver | 1993 |
[Clinical aspects of drug-alcohol interactions].
Topics: Acetaldehyde; Acetaminophen; Alcohol Deterrents; Alcohol Drinking; Animals; Carbon Tetrachloride; Cephalosporins; Cytochrome P-450 Enzyme System; Drug Interactions; Ethanol; Histamine H2 Antagonists; Humans; Liver | 1997 |
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2E1; Mice; Mice, Knockout; Xenobiotics | 2001 |
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Disease Models, Animal; Galactosamine; Hepatectomy; Humans; Liver Failure, Acute; Liver Regeneration | 2009 |
An update on oxidative stress-mediated organ pathophysiology.
Topics: Acetaminophen; Animals; Antioxidants; Arsenic; Cadmium; Carbon Tetrachloride; Cisplatin; Diabetes Mellitus; Doxorubicin; Drug-Related Side Effects and Adverse Reactions; Humans; Lead; Mercury; Oxidative Stress; Sulfonamides | 2013 |
[Hepatoprotective effects of extracts and polysaccharides from seaweed].
Topics: Acetaminophen; Aflatoxins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diclofenac; Hepatitis C, Chronic; Humans; Immunologic Factors; Nitroso Compounds; Polysaccharides; Seaweed | 2014 |
Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Diethylnitrosamine; Hexachlorocyclohexane; Humans; Liver; Metals, Heavy; Oxidative Stress; Protective Agents | 2019 |
Animal models of drug-induced liver injury.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Humans; Immune Tolerance | 2019 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Amylose; Anaerobiosis; Animals; Anti-Bacterial Agents; Anura; Arginase; Arthritis, Rheumatoid; Asthma; Atmosphere; B-Lymphocytes; Basic Helix-Loop-Helix Transcription Factors; Bioelectric Energy Sources; Biofilms; Biofuels; Biomarkers; Biopolymers; Bioreactors; Brain; Brain Injuries, Traumatic; Breast Neoplasms; Calibration; Carbon Tetrachloride; Caspase 3; Catalysis; Catechin; Cations; Cattle; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Body; Cell Line, Tumor; Cell Plasticity; Chemical and Drug Induced Liver Injury; Chemistry Techniques, Synthetic; China; Chitosan; Chloride Channels; Chromatography, High Pressure Liquid; Chromosome Mapping; Cognition; Cognitive Dysfunction; Cohort Studies; Colitis, Ulcerative; Colloids; Coloring Agents; Congresses as Topic; Correlation of Data; Crystallization; Cyanoacrylates; Cyclohexane Monoterpenes; Cyprinidae; Cytochrome P-450 CYP1A1; Death, Sudden; Dent Disease; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Disease Progression; Disease Resistance; Disulfides; Drug Monitoring; Drug Stability; Ecotoxicology; Electricity; Electrodes; Endocytosis; Environmental Exposure; Environmental Monitoring; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Esophageal and Gastric Varices; Esters; Fagopyrum; Female; Ferrosoferric Oxide; Flame Retardants; Flavobacteriaceae; Flow Cytometry; Follow-Up Studies; Formoterol Fumarate; Fusarium; Garlic; Gastrointestinal Hemorrhage; Gene Expression; Genes, Plant; Genetic Markers; Glial Fibrillary Acidic Protein; Gliosis; Global Health; Glutathione Transferase; Glycine max; Gum Arabic; Hemostasis, Endoscopic; Hepatocytes; Hippocampus; Humans; Hydrogen-Ion Concentration; Illinois; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant, Newborn; Infant, Small for Gestational Age; Injections, Intraperitoneal; Interleukin-4; Iowa; Iron; Ki-67 Antigen; Kidney; Kinetics; Kynurenine; Lakes; Levofloxacin; Lipid Peroxidation; Lipids; Liver; Liver Cirrhosis, Experimental; Magnetic Fields; Magnetic Iron Oxide Nanoparticles; Male; Manure; Maze Learning; Memory, Short-Term; Metal Nanoparticles; Metals, Heavy; Methane; Mice; Mice, Inbred C57BL; Mice, Knockout; Michigan; Microalgae; Microbial Consortia; Mitochondria; Models, Animal; Models, Chemical; Models, Neurological; Molecular Structure; Molecular Weight; Mutation; Myeloid-Derived Suppressor Cells; NADPH Oxidase 2; Neoplasm Recurrence, Local; Neurites; Neurons; Neuroprotective Agents; NF-kappa B; NIH 3T3 Cells; Nitric Oxide Synthase Type II; Nitrogen; Ohio; Ointments; Ontario; Organelle Biogenesis; Organophosphates; Organophosphorus Compounds; Oxidative Stress; Palladium; Particle Size; Pectins; Phenotype; Phytotherapy; Piperidines; Placenta; Plant Diseases; Plant Extracts; Polymers; Polymorphism, Genetic; Polyphenols; Powders; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Protein Kinase Inhibitors; Protein Structure, Secondary; Proteins; Pyridines; Pyrimidines; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Receptors, Chemokine; Receptors, Formyl Peptide; Receptors, Lipoxin; Recovery of Function; Recurrence; Reference Standards; Reference Values; Reproducibility of Results; Respiratory Function Tests; Retrospective Studies; Risk; Sensitivity and Specificity; Sewage; Signal Transduction; Sodium Glutamate; Soil; Solanum tuberosum; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spermatozoa; STAT3 Transcription Factor; Sulfamethoxazole; Tea; Temperature; Thermodynamics; Thrombin; Treatment Outcome; Triazoles; United States; Viscosity; Waste Disposal, Fluid; Wastewater; Water; Water Pollutants, Chemical; Water Purification; White Matter; Wisconsin; X-Ray Diffraction; Zea mays | 2013 |
1 trial(s) available for acetaminophen and carbon tetrachloride
150 other study(ies) available for acetaminophen and carbon tetrachloride
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Biochemical changes after hepatic injury by allyl alcohol and N-hydroxy-2-acetylaminofluorene.
Topics: Acetaminophen; Allyl Compounds; Aniline Hydroxylase; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Cytochromes; Cytosol; Dimethylnitrosamine; Ethylmorphine-N-Demethylase; Fluorenes; Furosemide; Glucose-6-Phosphatase; Hydroxyacetylaminofluorene; Liver; Liver Regeneration; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrogenase; Proteins; Rats | 1976 |
Comparison of in vivo and in vitro drug metabolism in experimental hepatic injury in the rat.
Topics: Acetaminophen; Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; In Vitro Techniques; Liver; Liver Diseases; Male; Microsomes, Liver; Proteins; Rats | 1979 |
[Effects of astragalus (ASI, SK) on experimental liver injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Galactosamine; Glucosides; Glutathione; Male; Malondialdehyde; Mice; Microsomes, Liver; Rats; Saponins; Triterpenes | 1992 |
Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Indomethacin; Isoniazid; Lipid Peroxides; Male; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Thioacetamide | 1992 |
Potentiation of the toxicity of model hepatotoxicants by acetaminophen.
Topics: 1-Propanol; Acetaminophen; Alanine Transaminase; Animals; Bromobenzenes; Carbon Tetrachloride; Dichloroethylenes; Drug Synergism; Liver; Male; Models, Biological; Propanols; Rats; Rats, Inbred Strains; Thioacetamide; Time Factors | 1991 |
Spontaneous and xenobiotic-induced in vivo-lipid peroxidation in iron-overloaded rats.
Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride; Ethanol; Hemochromatosis; Iron; Iron-Dextran Complex; Lipid Peroxidation; Liver; Male; Rats; Rats, Inbred Strains; Xenobiotics | 1989 |
In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity.
Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Lipid Peroxidation; Liver Diseases; Mice; Microsomes, Liver; NADP; Oligopeptides; Pimelic Acids | 1989 |
Evidence in vivo for elevation of intracellular free Ca2+ in the liver after diquat, acetaminophen, and CCl4.
Topics: Acetaminophen; Animals; Calcium; Carbon Tetrachloride; Deferoxamine; Diquat; Lipid Peroxidation; Liver; Male; Phosphorylase a; Pyridinium Compounds; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1989 |
Acute carbon tetrachloride poisoning in 19 patients: implications for diagnosis and treatment.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Aged; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Child; Child, Preschool; Chromatography, Gas; Female; Humans; Male; Middle Aged | 1985 |
Alkylating toxins and the liver plasma membrane calcium pump/calcium atpase.
Topics: Acetaminophen; Animals; Bromobenzenes; Calcium; Calcium-Transporting ATPases; Carbon Tetrachloride; Cell Membrane; Homeostasis; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Alteration of chemically induced hepatotoxicity by copper (II) (3,5-diisopropylsalicylate)2.
Topics: Acetaminophen; Animals; Antineoplastic Agents; Carbon Tetrachloride; Lipid Peroxides; Liver; Male; Mice; Rats; Rats, Inbred Strains; Salicylates; Superoxides | 1985 |
Effect of acetaminophen hepatotoxicity on hepatic mitochondrial and microsomal calcium contents in mice.
Topics: Acetaminophen; Animals; Calcium; Carbon Tetrachloride; Cytosol; L-Iditol 2-Dehydrogenase; Male; Mice; Microsomes, Liver; Mitochondria, Liver | 1988 |
Development of paracetamol induced hepatocellular tolerance in albino rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Drug Tolerance; Liver; Necrosis; Rats; Rats, Inbred Strains | 1988 |
Protection by dimethylsulfoxide against acetaminophen-induced hepatic, but not respiratory toxicity in the mouse.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Dimethyl Sulfoxide; Female; Free Radicals; Glutathione; Liver; Lung; Mice; Necrosis; Respiratory System | 1988 |
Influence of pyrazolones on hepatic glutathione in rats.
Topics: 1-Propanol; Acetaminophen; Aminopyrine; Animals; Antipyrine; Carbon Tetrachloride; Cobalt; Female; Glutathione; Liver; Phenobarbital; Propanols; Pyrazoles; Rats; Rats, Inbred Strains; Thioacetamide | 1985 |
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.
Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Dimethylnitrosamine; Liver; Male; Microsomes, Liver; Necrosis; Rats; Rats, Inbred Strains; Thioacetamide | 1986 |
Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats.
Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glucuronates; Glutathione; Ketones; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Sulfates | 1985 |
Failure of exogenous prostaglandin to afford complete protection against acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Galactosamine; Gastric Mucosa; Liver; Male; Prostaglandins; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains | 1985 |
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity.
Topics: Acetaminophen; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Deferoxamine; Enzyme Induction; Ethane; Iron; Lipid Peroxides; Male; Mice; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Potentiation of carbon tetrachloride hepatotoxicity by beta-phenethyl alcohol.
Topics: Acetaminophen; Alanine Transaminase; Alcohols; Animals; Carbon Tetrachloride; Drug Synergism; Ethanol; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylethyl Alcohol; Rats; Rats, Inbred Strains | 1984 |
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Ethanol; Fentanyl; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Methotrexate; Oxytetracycline; Protein Biosynthesis; Rats; Valine | 1984 |
Histological & ultrastructural alterations in the livers of albino rats after prolonged administration of paracetamol.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Necrosis; Rats | 1983 |
Effects of phenobarbital, GSH-depletors, CCl4 and ethanol on the biliary efflux of glutathione in rats.
Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Dichloroethylenes; Ethanol; Glutathione; Ketones; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Measurement of the oxidation rate of volatile alkanes: a new and non-invasive procedure for testing the drug-metabolizing capacity of the liver.
Topics: Acetaminophen; Alkanes; Animals; Biotransformation; Carbon Tetrachloride; Liver; Male; Metabolic Clearance Rate; Mice; Oxidation-Reduction; Pharmaceutical Preparations; Rats | 1984 |
Free radicals in vivo. Covalent binding to lipids.
Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Dimethylnitrosamine; Free Radicals; Furans; Furosemide; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred ICR; Rats; Rats, Inbred Strains | 1984 |
[Inhibitory and stimulatory effects on the metabolic disposition of paracetamol in rats (author's transl)].
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Enzyme Induction; Enzyme Inhibitors; Glucuronates; Hepatectomy; Kidney; Liver; Male; Rats | 1980 |
Interference of chemicals with glycogen metabolism in isolated hepatocytes.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Membrane; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Liver Glycogen; Male; Phosphorylase a; Rats; Time Factors | 1980 |
Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide.
Topics: Acetaminophen; Allyl Compounds; Animals; Bromobenzenes; Carbon Tetrachloride; Ethanol; Hemodynamics; Hypoxia; Liver; Male; Rats; Thioacetamide | 1980 |
Dr. Henry Baker Lecture Interaction of ethanol with drug toxicity.
Topics: Acetaminophen; Alcoholic Beverages; Alcoholic Intoxication; Alcoholism; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Tolerance; Ethanol; Humans; Inactivation, Metabolic; Liver; Microsomes, Liver; Pharmaceutical Preparations | 1980 |
[Influence of pretreatment with carbon tetrachloride on paracetamol-induced hepatotoxicity].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; Lipids; Liver; Male; Rats; Triglycerides | 1980 |
Evaluation of the protective potential of Artemisia maritima extract on acetaminophen- and CCl4-induced liver damage.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Liver; Liver Diseases; Male; Methanol; Mice; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sleep; Water | 1995 |
Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Synergism; Lethal Dose 50; Liver Diseases; Male; Mice; Pentobarbital; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sleep; Strychnine | 1995 |
The interactions between retinol and five different hepatotoxicants in the Swiss Webster mouse.
Topics: 1-Propanol; Acetaminophen; Animals; Carbon Tetrachloride; Diterpenes; Drug Interactions; Drug Synergism; Galactosamine; Liver; Male; Mice; Phalloidine; Propanols; Retinoids; Retinyl Esters; Transaminases; Vitamin A | 1995 |
Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxicants: effect of glucose loading.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Division; Chloroform; Cytochrome P-450 Enzyme System; Death; DNA; Glucose; Liver; Male; Microsomes, Liver; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Thioacetamide | 1995 |
Effect of ursodeoxycholic acid on in vivo and in vitro toxic liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Ethanol; Lipid Peroxides; Liver; Liver Diseases; Male; Rats; Ursodeoxycholic Acid; Valine | 1994 |
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Topics: 1-Propanol; Acetaminophen; Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Liver Diseases; Male; Mice; Mice, Inbred Strains; Propanols | 1994 |
Kupffer cell stimulation with Corynebacterium parvum reduces some cytochrome P450-dependent activities and diminishes acetaminophen and carbon tetrachloride-induced liver injury in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biotransformation; Carbon Tetrachloride; Cells, Cultured; Coumarins; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Galactosamine; Glutathione; Immunization; Kupffer Cells; Liver; Male; Microsomes, Liver; Nitrophenols; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Propionibacterium acnes; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1994 |
Hepatoprotective effects of Taiwan folk medicine: wedelia chinensis on three hepatotoxin-induced hepatotoxicity.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Galactosamine; Liver; Male; Mice; Mice, Inbred ICR; Microscopy, Fluorescence; Paraffin Embedding; Random Allocation; Rats; Rats, Wistar; Taiwan | 1994 |
Subpopulations of rat hepatocytes separated by Percoll density-gradient centrifugation show characteristics consistent with different acinar locations.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Cell Separation; Cell Survival; Cells, Cultured; Centrifugation, Density Gradient; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Male; Methotrexate; Pyruvate Kinase; Rats; Rats, Wistar | 1994 |
Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophoresis; Liver; Liver Diseases; Male; Membranes; Mice | 1993 |
Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: comparison with carbon tetrachloride.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Interactions; Ethanol; Lipid Peroxidation; Liver Diseases; Male; Microsomes, Liver; Models, Biological; Rats; Rats, Sprague-Dawley | 1993 |
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury.
Topics: 1-Propanol; Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Liver Diseases; Male; Propanols; Rats; Rats, Sprague-Dawley; Retinyl Esters; Vitamin A | 1993 |
Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.
Topics: Acetaminophen; Carbon Tetrachloride; Cell Line; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Humans; Hydrolysis; Microsomes; Nitrophenols; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Protective and therapeutic effects of Curcuma xanthorrhiza on hepatotoxin-induced liver damage.
Topics: Acetaminophen; Adult; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Humans; Liver; Male; Medicine, East Asian Traditional; Mice; Mice, Inbred ICR | 1995 |
Actions of selected hepatotoxicants on freshly isolated and cryopreserved rat hepatocytes.
Topics: 1-Propanol; Acetaminophen; Adenosine Triphosphate; Animals; Carbon Tetrachloride; Cell Separation; Cryopreservation; Digitonin; Energy Metabolism; In Vitro Techniques; Liver; Male; Oxygen Consumption; Propanols; Rats; Rats, Sprague-Dawley; Urea | 1996 |
The protective effect of Alstonia scholaris R. Br. on hepatotoxin-induced acute liver damage.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Dose-Response Relationship, Drug; Ethanol; Galactosamine; Injections, Intraperitoneal; Liver; Male; Medicine, Traditional; Mice; Plant Extracts; Rats; Rats, Wistar; Transaminases | 1996 |
Selective protective effect of an extract from Fumaria parviflora on paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Enzyme Inhibitors; Liver; Male; Mice; Plant Extracts; Rats; Rats, Wistar; Strychnine | 1996 |
Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Cholesterol Esters; Doxorubicin; Galactosamine; Heart Diseases; Liver Diseases; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley | 1997 |
Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Female; Gene Expression Regulation; Immunoglobulin M; Liver; Lymphokines; Mice; Mice, Inbred Strains; NF-kappa B; Pregnancy; Protein Binding; RNA, Messenger; Spleen; Th2 Cells; Transforming Growth Factor beta | 1997 |
Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Galactosamine; Glycyrrhetinic Acid; Glycyrrhizic Acid; Liver; Male; Medicine, East Asian Traditional; Plant Extracts; Rats; Rats, Wistar; Silymarin; Taiwan | 1997 |
Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction.
Topics: Acetaminophen; Amphetamine; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cocaine; Fever; Heat-Shock Proteins; Hyperthermia, Induced; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred ICR | 1997 |
Esculetin prevents liver damage induced by paracetamol and CCL4.
Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Mice; Rats; Rats, Wistar; Sleep; Umbelliferones | 1998 |
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fumarates; Galactosamine; Liver; Male; Maleates; Plant Extracts; Rats; Rats, Wistar; Rifampin; Silymarin; Thioacetamide | 1998 |
An assessment of the potential of protopine to inhibit microsomal drug metabolising enzymes and prevent chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Alkaloids; Animals; Benzophenanthridines; Berberine Alkaloids; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Liver; Male; Microsomes, Liver; Pentobarbital; Rats; Rats, Wistar; Sleep; Strychnine | 1998 |
Effects of Corylus avellana in acetaminophen and CCl4 induced toxicosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver Diseases; Liver Function Tests; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 1999 |
Acarbose and acetaminophen- a dangerous combination?
Topics: Acarbose; Acetaminophen; Animals; Body Surface Area; Carbon Tetrachloride; Drug Synergism; Ethanol; Humans; Hypoglycemic Agents; Liver; Rats; Species Specificity; Trisaccharides | 1999 |
Potentiation of paracetamol and carbon tetrachloride-induced hepatotoxicity in rodents by the food additive vanillin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzaldehydes; Carbon Tetrachloride; Drug Synergism; Food Additives; Liver; Male; Mice; Pentobarbital; Rats; Rats, Wistar; Sleep; Strychnine | 1999 |
Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Carbon Tetrachloride; Gene Expression Regulation; Genes, fos; Genes, jun; Glutamate-Cysteine Ligase; Liver; Male; Maleates; Mice; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1 | 2000 |
Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Interleukin-1; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred C3H | 2000 |
Yang-Gan-Wan protects mice against experimental liver damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Poisons; Propanols | 2000 |
Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Antioxidants; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Liver; Liver Diseases; Male; Mice; Mice, Inbred ICR; Plant Extracts; Plant Roots; Poisons | 2000 |
Effect of liquid extract from fresh Abutilon indicum leaves and Allium cepa bulbs on paracetamol and carbontetrachloride induced hepatotoxicity.
Topics: Acetaminophen; Allium; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Function Tests; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar | 2000 |
Antioxidant and hepatoprotective effects of Acathopanax senticosus.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Free Radical Scavengers; Lipid Peroxidation; Liver; Male; Medicine, Chinese Traditional; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Taiwan; Xanthine Oxidase | 2000 |
Screening of various Swertia species extracts in primary monolayer cultures of rat hepatocytes against carbon tetrachloride- and paracetamol-induced toxicity.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cells, Cultured; Hepatocytes; In Vitro Techniques; L-Lactate Dehydrogenase; Magnoliopsida; Male; Plant Extracts; Rats; Tumor Cells, Cultured | 2001 |
Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Magnoliopsida; Male; Mice; Pentobarbital; Plants, Medicinal; Rats; Rats, Wistar; Sleep; Strychnine | 2000 |
Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Glycosaminoglycans; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley | 2001 |
Effect of a herbal protein CI-1, purified from Cajanus indicus on the ultrastructural study of hepatocytes, in models of liver failure in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Central Nervous System Depressants; Ethanol; Fabaceae; Galactosamine; Liver; Liver Failure; Male; Mice; Phytotherapy; Plant Extracts; Plant Leaves; Plant Proteins; Plants, Medicinal | 2001 |
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Hypoglycemic Agents; Injections, Intraperitoneal; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Mutant Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Ameliorative effect of Silene aprica on liver injuries induced by carbon tetrachloride and acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Lipid Peroxidation; Liver; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Silene | 2002 |
Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver Diseases; Male; Mice; Phytotherapy; Rats; Rats, Wistar; Rutin; Sleep; Survival Rate | 2002 |
The formation of oxidative stress condition in the experimental chemically induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Lipid Peroxidation; Liver; Liver Diseases; Liver Function Tests; Male; Oxidative Stress; Rats; Rats, Wistar; Reference Values; Risk Assessment; Sensitivity and Specificity | 2002 |
Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Bromobenzenes; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Colchicine; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA; Drug Therapy, Combination; Liver; Liver Regeneration; Male; Mice; Microsomes, Liver; Proliferating Cell Nuclear Antigen | 2003 |
Glycosmis arborea extract as a hepatoprotective agent.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Lethal Dose 50; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Rutaceae; Superoxide Dismutase; Survival Rate; Toxicity Tests, Acute | 2003 |
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dipeptides; Disease Progression; Hepatocytes; Immunohistochemistry; Liver Diseases; Male; Mice; Microfilament Proteins; Necrosis; Random Allocation; Rats; Rats, Sprague-Dawley | 2003 |
Hepatoprotective effect of Himoliv, a polyherbal formulation in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; Liver Diseases; Male; Plant Preparations; Plants, Medicinal; Rats; Rats, Wistar | 2003 |
Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Mice; Phytotherapy; Plants, Medicinal; Protective Agents; Quercetin; Rats | 2004 |
Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Gene Expression; Gene Expression Profiling; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Liver; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Oligonucleotide Array Sequence Analysis; Organic Anion Transporters | 2005 |
Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Male; Malvaceae; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Wistar | 2005 |
Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes.
Topics: Acetaminophen; Aflatoxin B1; Albumins; Animals; Benzoquinones; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Collagen; Cytochrome P-450 Enzyme System; Dimethylformamide; Glucuronides; Glutathione; Hepatocytes; Isoenzymes; L-Lactate Dehydrogenase; Mass Spectrometry; Oxazines; Rats; Sulfates; Urea; Vinyl Compounds; Xanthenes | 2005 |
Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bromobenzenes; Carbon Tetrachloride; Dimethylnitrosamine; Gene Expression Profiling; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Sprague-Dawley; Thioacetamide | 2005 |
Chemistry and hepatoprotective activity of an active fraction from Barleria prionitis Linn. in experimental animals.
Topics: Acanthaceae; Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Galactosamine; Lethal Dose 50; Male; Mice; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Protective Agents; Rats | 2005 |
Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice.
Topics: Acetaminophen; Amaranth Dye; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Hepatitis, Animal; Indocyanine Green; Liver; Male; Mice; Mice, Inbred Strains; Rose Bengal; Sulfobromophthalein | 2006 |
Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.
Topics: Acetaminophen; Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Regulation; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Multidrug Resistance-Associated Proteins; Up-Regulation | 2006 |
Liquid chromatography-mass spectrometric analysis of urinary metabolites and their pattern recognition for the prediction of drug-induced hepatotoxicity.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Algorithms; Animals; Carbon Tetrachloride; Chromatography, Liquid; Computer Simulation; Diclofenac; Liver; Male; Mass Spectrometry; Rats; Structure-Activity Relationship | 2005 |
Contrasting changes in phase I and phase II metabolism of acetaminophen in male mice pretreated with carbon tetrachloride.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; L-Iditol 2-Dehydrogenase; Liver; Male; Mice; Mice, Inbred ICR | 2006 |
In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system.
Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Hepatocytes; Kupffer Cells; Liver; Male; Oxidative Stress; Proteins; Proteomics; Rats; Rats, Inbred Strains; Tetracycline; Toxicity Tests | 2006 |
Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants.
Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Carbon Tetrachloride; Liver; Male; Proteins; Proteomics; Rats; Rats, Inbred Strains; Tetracycline | 2006 |
Hepatoprotective activity of Psidium guajava Linn. leaf extract.
Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Chronic; Liver; Liver Diseases; Male; Necrosis; Organ Size; Phytotherapy; Plant Extracts; Plant Leaves; Psidium; Rats; Rats, Wistar | 2006 |
Hepatoprotective activity of Hemidesmus indicus R. br. in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hemidesmus; Liver; Plant Extracts; Rats; Rats, Wistar | 2006 |
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hexanes; Liver; Liver Diseases; Necrosis; Organ Size; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Resins, Plant; Silymarin; Thioacetamide | 2006 |
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids, Monounsaturated; Female; Hexobarbital; Hypnotics and Sedatives; Indigofera; Inert Gas Narcosis; Liver Diseases; Male; Mice; Nuclear Magnetic Resonance, Biomolecular; Paralysis; Phytotherapy; Protective Agents; Rats; Rats, Wistar; Zoxazolamine | 2006 |
Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity.
Topics: Acetaminophen; Animals; Animals, Newborn; Calcium-Binding Proteins; Calpain; Carbon Tetrachloride; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Disease Models, Animal; Disease Progression; Hepatocytes; Immunohistochemistry; Liver; Liver Failure, Acute; Liver Regeneration; Male; Mice; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2006 |
Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Enzymes; Ethanol; Female; Hepatocytes; Liver; Liver Diseases; Male; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Rhizome; Zingiber officinale | 2006 |
Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion.
Topics: Acetaminophen; Animals; Antioxidants; Biphenyl Compounds; Bupleurum; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Hepatocytes; Lipid Peroxidation; Liver; Male; Picrates; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Superoxides | 2006 |
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Biopsy; Carbon Tetrachloride; Cell Death; Disease Models, Animal; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Necrosis Factor-alpha | 2007 |
Genomic cluster and network analysis for predictive screening for hepatotoxicity.
Topics: Acetaminophen; Amiodarone; Animals; Carbon Tetrachloride; Cluster Analysis; Gene Expression; Gene Expression Profiling; Liver; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred Strains; Tetracycline | 2006 |
Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Female; Hepatectomy; Hepatocytes; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Necrosis; Orchiectomy; Organ Specificity; Oxidoreductases, O-Demethylating; Sex Factors; Testosterone | 2007 |
Changes of micro-RNA expression in rat liver treated by acetaminophen or carbon tetrachloride--regulating role of micro-RNA for RNA expression.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Line; Cell Survival; Gene Expression Regulation; Hepatocytes; Liver; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Alanine Transaminase; Analysis of Variance; Animals; Blotting, Western; Bromobenzenes; Carbon Tetrachloride; Cell Nucleus; Cytoskeletal Proteins; Furosemide; Glutamate-Cysteine Ligase; Glutathione; Heme Oxygenase-1; Injections, Intraperitoneal; Kelch-Like ECH-Associated Protein 1; Liver; Male; Mice; Molecular Structure; NF-E2-Related Factor 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Xenobiotics | 2008 |
The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis.
Topics: Acetaminophen; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; DNA; Female; L-Lactate Dehydrogenase; Liver; Mice; Mice, Inbred BALB C; Necrosis | 2008 |
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Down-Regulation; Fibrosis; Forecasting; Gliotoxin; Inflammation; Lipopolysaccharides; Liver; Male; Necrosis; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Time Factors; Toxicity Tests; Up-Regulation | 2008 |
Hepatoprotective effect of Hibiscus hispidissimus Griffith, ethanolic extract in paracetamol and CCl4 induced hepatotoxicity in Wistar rats.
Topics: Acetaminophen; Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Free Radical Scavengers; Hibiscus; Lipid Peroxidation; Liver Diseases; Male; Picrates; Plant Extracts; Rats; Rats, Wistar | 2008 |
Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Liver; Male; Phytotherapy; Plant Extracts; Plant Leaves; Psidium; Rats; Rats, Wistar; Silymarin; Solvents | 2010 |
Protective activity of the stem bark aqueous extract of Musanga cecropioides in carbon tetrachloride- and acetaminophen-induced acute hepatotoxicity in rats.
Topics: Acetaminophen; Alkaloids; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carboxyl and Carbamoyl Transferases; Chemical and Drug Induced Liver Injury; Flavonoids; Liver; Male; Nigeria; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats; Rats, Wistar; Transaminases; Urticaceae | 2009 |
Resveratrol and liver disease: from bench to bedside and community.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrachloride; Cytokines; Ethanol; Free Radicals; Glutathione; Hepatocytes; Humans; Liver Diseases; NF-kappa B; Resveratrol; Stilbenes | 2010 |
Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Biomarkers; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Glutathione Peroxidase; Hydroxyproline; Lipid Peroxidation; Liver; Lutein; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2010 |
Protective effects of Pergularia daemia roots against paracetamol and carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Female; India; Lipid Peroxidation; Male; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Silymarin | 2010 |
Hepato-protective potential of carotenoid meso-zeaxanthin against paracetamol, CCl4 and ethanol induced toxicity.
Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Biomarkers; Carbon Tetrachloride; Catalase; Dose-Response Relationship, Drug; Ethanol; Glutathione; Glutathione Peroxidase; Liver; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Superoxide Dismutase; Xanthophylls; Zeaxanthins | 2011 |
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Genetic Markers; Liver; Male; MicroRNAs; Necrosis; Penicillins; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Risk Assessment; Time Factors; Toxicity Tests; Urinalysis | 2012 |
Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Discriminant Analysis; Liver; Male; Mass Spectrometry; Metabolome; Metabolomics; Methotrexate; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Steroids | 2012 |
Impairment of α(2)-macroglobulin synthesis in experimental hepatopathic rats treated with turpentine oil.
Topics: Acetaminophen; Acute Disease; alpha-Macroglobulins; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Injections, Intramuscular; Irritants; Liver; Liver Function Tests; Male; Rats; Rats, Sprague-Dawley; Turpentine | 2012 |
Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity.
Topics: Acetaminophen; Actins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Gene Expression; Gene Expression Profiling; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver; MicroRNAs; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Nuclear; Thioacetamide | 2012 |
Protective effects of a purified saponin mixture from Astragalus corniculatus Bieb., in vivo hepatotoxicity models.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Astragalus Plant; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; L-Lactate Dehydrogenase; Liver; Liver Function Tests; Male; Malondialdehyde; Plant Extracts; Rats; Rats, Wistar; Saponins; Silymarin | 2013 |
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carboxypeptidase B2; Chemical and Drug Induced Liver Injury; Chronic Disease; Collagen Type I; Collagen Type I, alpha 1 Chain; Fibrin; Gene Expression Regulation; Liver; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neutrophil Infiltration; RNA, Messenger; Time Factors | 2013 |
Hepatoprotective activity of Hepax-a polyherbal formulation.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Humans; India; Liver; Male; Phytotherapy; Plant Extracts; Plants, Medicinal; Protective Agents; Rats; Rats, Wistar | 2011 |
Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ceramides; Chemical and Drug Induced Liver Injury; Connexins; Galactosamine; Gap Junction beta-1 Protein; Gap Junctions; Glutathione; Hepatocytes; Membrane Microdomains; Mice; Mice, Mutant Strains; Sphingosine N-Acyltransferase | 2013 |
Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Cell Survival; Dimethylnitrosamine; Glutathione; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Liver; Liver Cirrhosis; Male; Malondialdehyde; Protective Agents; Rats, Wistar; Reactive Oxygen Species; Serum Albumin; Superoxide Dismutase; Swertia; Xanthones | 2014 |
The biliary epithelium gives rise to liver progenitor cells.
Topics: Acetaminophen; Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cells, Cultured; Chemical and Drug Induced Liver Injury; Diet; Disease Models, Animal; Epithelial Cells; Female; Hepatocyte Nuclear Factor 1-beta; Hepatocytes; Homeostasis; Humans; Liver; Liver Regeneration; Male; Mice; Mice, Transgenic; Stem Cells | 2014 |
Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models.
Topics: Acetaminophen; Animals; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Exosomes; Hepatocytes; Humans; Hydrogen Peroxide; Liver Regeneration; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
Protective effects of Baccharis dracunculifolia leaves extract against carbon tetrachloride- and acetaminophen-induced hepatotoxicity in experimental animals.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Baccharis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Free Radical Scavengers; Liver; Male; Mice; Plant Extracts; Plant Leaves; Rats, Wistar | 2014 |
Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ferns; Liver; Male; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley | 2014 |
Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Complex Mixtures; Disease Models, Animal; Gentamicins; Kidney; Kidney Function Tests; Liver; Liver Failure; Liver Function Tests; Nigeria; Pleurotus; Rats, Wistar; Renal Insufficiency; Treatment Outcome | 2014 |
Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytoglobin; Globins; Hepatic Stellate Cells; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxygen; Xenobiotics | 2015 |
Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Gene Expression Profiling; Liver; Liver Cirrhosis; Male; Oligonucleotide Array Sequence Analysis; Rats, Wistar; RNA, Messenger | 2015 |
[Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver Cirrhosis; Mice; Protective Agents | 2015 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diterpenes; Emodin; Epoxy Compounds; Hepatocytes; Humans; Mass Spectrometry; Metabolomics; Phenanthrenes | 2015 |
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Case-Control Studies; Cell Death; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzyme Activation; Female; Gene Expression Profiling; Hepatocytes; Humans; Liver Failure, Acute; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Time Factors; Young Adult | 2016 |
A Systematic Strategy for Screening and Application of Specific Biomarkers in Hepatotoxicity Using Metabolomics Combined With ROC Curves and SVMs.
Topics: Acetaminophen; Animals; Atorvastatin; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Liver; Male; Metabolomics; Rats, Wistar; ROC Curve; Sensitivity and Specificity; Support Vector Machine | 2016 |
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Topics: Acetaminophen; Adult; Aged; Animals; Biomarkers; Blood Chemical Analysis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Mice; Middle Aged; Proteomics | 2016 |
Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Carrier Proteins; Cell Line, Tumor; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Hepatocytes; Inflammation; Intracellular Signaling Peptides and Proteins; Liver Cirrhosis; Male; Mice; Multiprotein Complexes; Protein Binding; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases | 2017 |
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.
Topics: Acetaminophen; Acute Lung Injury; Animals; Autophagy; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation; Genes, Tumor Suppressor; Hep G2 Cells; Hepatectomy; Hepatocytes; Humans; Kruppel-Like Factor 6; Liver; Liver Neoplasms; Liver Regeneration; Mice; Mice, Inbred C57BL; Transcription, Genetic; Transcriptional Activation | 2017 |
Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
Topics: Acetaminophen; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Flavonoids; Glycyrrhiza; Hep G2 Cells; Humans; Liver; Molecular Structure; Phenols; Plant Extracts; Protective Agents; Structure-Activity Relationship | 2017 |
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.
Topics: Acetaminophen; Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Female; Hematopoietic Stem Cells; Hepatocytes; Humans; Inflammation Mediators; Kupffer Cells; Lipid Peroxidation; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Membrane Glycoproteins; Mice, Knockout; Middle Aged; Reactive Oxygen Species; Receptors, Immunologic; Toll-Like Receptor 4; Up-Regulation | 2019 |
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF MELILOTUS OFFICINALIS L. AGAINST PARACETAMOL AND CARBON TETRACHLORIDE INDUCED HEPATIC INJURY IN MICE.
Topics: Acetaminophen; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Female; Free Radical Scavengers; Liver; Male; Melilotus; Mice; Oxidative Stress; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal | 2017 |
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Carvedilol; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Glutathione; Hepatic Stellate Cells; Liver; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Oxidative Stress; Propranolol; Rats, Wistar; Tumor Necrosis Factor-alpha | 2021 |
Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen; DNA Repair; DNA Replication; Hepatic Stellate Cells; Liver Cirrhosis, Experimental; Male; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Serine; Signal Transduction | 2019 |
Genome-Scale Characterization of Toxicity-Induced Metabolic Alterations in Primary Hepatocytes.
Topics: Acetaminophen; Activation, Metabolic; Animals; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Computational Biology; Gene Expression Profiling; Hepatocytes; Male; Metabolic Networks and Pathways; Metabolomics; Polychlorinated Dibenzodioxins; Primary Cell Culture; Rats, Sprague-Dawley; Transcriptome; Trichloroethylene | 2019 |
Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents, Local; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Glutathione Peroxidase; Inflammation; Male; Mice; NF-E2-Related Factor 2; Nuts; Oxidative Stress; Pinus; Polysaccharides; Superoxide Dismutase | 2020 |
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.
Topics: Acetaminophen; Animals; Blood Platelets; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Humans; Lectins, C-Type; Liver; Mice; Mice, Inbred C57BL; Neutrophils; Tumor Necrosis Factor-alpha | 2020 |
Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats.
Topics: Acetaminophen; Acute Disease; Amino Acids; Animals; Biomarkers; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gene Expression Profiling; Hazardous Substances; Hepatocytes; Lipid Metabolism; Liver; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Prognosis; Rats; Rats, Sprague-Dawley; Transcriptome | 2020 |
Hepatoprotective and antioxidant activity of Dicliptera bupleuroides Nees. extracts on paracetamol induced hepatotoxicity in rats.
Topics: Acanthaceae; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Function Tests; Male; Oxidative Stress; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Silymarin | 2020 |
Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion.
Topics: Acetaminophen; Animals; Animals, Genetically Modified; Blood Circulation; Carbon Tetrachloride; Carthamus tinctorius; Chalcone; Chalcones; Chemical and Drug Induced Liver Injury; Fibrinolytic Agents; Glycosides; Hepatocytes; Humans; Male; Mice, Inbred ICR; Phenylhydrazines; Protective Agents; Quinones; Thrombosis; Zebrafish | 2021 |
Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Liver; Male; Mice; Oxidative Stress; Promoter Regions, Genetic; Proteolysis; RNA Splicing Factors; Transcriptional Activation | 2021 |
Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Lipocalin-2; Liver Diseases; Mice; Mycotoxins | 2022 |
Label-Free Imaging Techniques to Evaluate Metabolic Changes Caused by Toxic Liver Injury in PCLS.
Topics: Acetaminophen; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Hepatocytes; Humans; Liver; Liver Failure, Acute | 2023 |