acetaminophen has been researched along with buthionine sulfoximine in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.51) | 18.7374 |
| 1990's | 12 (30.77) | 18.2507 |
| 2000's | 10 (25.64) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Franklin, MR; Galinsky, RE; Kimura, RE; Manning, BW | 1 |
| Arancibia, C; Campos, R; Garrido, A; Valenzuela, A | 1 |
| Bray, GP; Tredger, JM; Williams, R | 1 |
| Chong, MG; He, DE; Kelly, JH; Koussayer, T; Shang, TA; Sussman, NL; Whisennand, HH | 1 |
| Corrales, F; Martin-Lomas, M; Mato, JM; Ochoa, P; Pajares, MA; Rivas, C | 1 |
| Bruno, M; Gamache, P; Hinson, JA; Khairallah, E; Klein, NW; Weeks, BS | 1 |
| Corcoran, GB; Wong, BK | 1 |
| Yeung, JH | 1 |
| Bauer, JA; Corcoran, GB; Lau, TW | 1 |
| Fricke, RF; Goon, DJ; Nagasawa, HT; Roberts, JC; Zera, RT | 1 |
| Galinsky, RE | 1 |
| Griffith, KL; Hue, DP; McLean, AE | 1 |
| Drew, R; Miners, JO | 1 |
| Birkett, DJ; Drew, R; Miners, JO | 1 |
| Fujihara, Y; Iguchi, S; Kaneo, Y; Ogawa, K; Tanaka, T | 1 |
| Barr, SG; Harrison, JJ; Racz, WJ; Rafeiro, E | 1 |
| Dalhoff, K; Poulsen, HE | 1 |
| Cargill, I; Howell, S; Lindenthal, J; Sinclair, JF; Sinclair, PR; Taylor, T | 1 |
| Bánhegyi, G; Braun, L; Csala, M; Garzó, T; Mandl, J; Poussu, A | 1 |
| Fumagalli, P; Galvani, P; Santagostino, A | 1 |
| Clement, YN; Dodd, CC; Kevin Park, B; Kitteringham, NR; McLellan, LI; Pirmohamed, M; Powell, H; Smith, DA; Tettey, JN | 1 |
| Chen, TS; Lang, CA; Nagasawa, HT; Richie, JP | 1 |
| Chen, TS; Song, H | 1 |
| Andou, A; Hirai, R; Inoue, Y; Miyazaki, M; Namba, M; Nozaki, I; Sakaguchi, M; Shimizu, N; Tsuji, T | 1 |
| Hodgson, HJ; Rahman, TM; Selden, AC | 1 |
| Arakawa, S; Igarashi, I; Manabe, S; Sagisaka, H; Shibaya, Y; Takasaki, W; Tanaka, K; Totsuka, S; Watanabe, M; Watanabe, T | 1 |
| Ito, K; Kanbori, M; Kiyosawa, N; Manabe, S; Matsunuma, N; Niino, N; Sakuma, K; Yamoto, T | 1 |
| Cohen, SD; Dominick, PK; Roberts, JC; Slitt, AM | 1 |
| Chen, C; Manautou, JE; Silva, VM; Thibodeau, MS | 1 |
| Ki, SH; Kim, CW; Kim, SC; Kim, SG; Kim, YW; Lee, JR; Lee, SJ | 1 |
| Gaarde, WA; Han, D; Jain, S; Kaplowitz, N; Shinohara, M; Than, TA; Win, S; Ybanez, MD | 1 |
| Ji, L; Liang, Q; Min, Y; Sheng, Y; Wang, Z; Xia, Y | 1 |
| Fisher, RL; Sinclair, JR; Vickers, AE | 1 |
| Fujimoto, K; Kishino, H; Manabe, S; Sanbuissho, A; Yamoto, T | 1 |
| Masubuchi, Y; Nakayama, J; Watanabe, Y | 1 |
| Gonsebatt, ME; Valdovinos-Flores, C | 1 |
| Andersen, ME; Aoyama, S; Khetani, SR; Krzyzewski, S; Lecluyse, EL; McVay, M; Rose, K; Ukairo, O | 1 |
| Hatao, K; Kimura, T; Kodama, T; Kumada, K; Kumano, A; Mori, K; Takano, N; Takiguchi, S | 1 |
| Abhyankar, S; Adelusi, O; Apte, U; Dawn, B; Duan, L; Jaeschke, H; Nguyen, NT; Ramachandran, A; Robarts, DR; Soder, RP; Umbaugh, DS; Woolbright, B | 1 |
39 other study(ies) available for acetaminophen and buthionine sulfoximine
| Article | Year |
|---|---|
Changes in conjugative enzyme activity and acetaminophen metabolism in young and senescent male F-344 rats following prolonged exposure to buthionine sulfoximine.
Topics: Acetaminophen; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Glutathione; Glutathione Transferase; Liver; Male; Methionine Sulfoximine; Oxidoreductases, O-Demethylating; Rats; Rats, Inbred F344; Sulfotransferases | 1992 |
Acetaminophen does not induce oxidative stress in isolated rat hepatocytes: its probable antioxidant effect is potentiated by the flavonoid silybin.
Topics: Acetaminophen; Animals; Antioxidants; Buthionine Sulfoximine; Drug Synergism; Glutamate-Cysteine Ligase; Glutathione; In Vitro Techniques; Lipid Peroxidation; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Silymarin; Stress, Physiological | 1991 |
S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mortality; S-Adenosylmethionine | 1992 |
An improved model of acetaminophen-induced fulminant hepatic failure in dogs.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biopsy; Blood Glucose; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Dogs; Liver; Liver Diseases; Male; Methemoglobinemia; Methionine Sulfoximine; Pulmonary Edema; Vacuoles | 1992 |
Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction.
Topics: Acetaminophen; Animals; Antimetabolites; Buthionine Sulfoximine; Glutathione; Liver; Male; Methionine Adenosyltransferase; Methionine Sulfoximine; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1991 |
Acetaminophen toxicity to cultured rat embryos.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Culture Techniques; Female; Glutathione; Macaca mulatta; Maternal-Fetal Exchange; Methionine Sulfoximine; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1990 |
Effects of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Esterases; Isoflurophate; Lysine; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Nitrophenols; Organophosphorus Compounds; Phenylmethylsulfonyl Fluoride | 1987 |
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds | 1988 |
Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Induced Liver Injury; Enzyme Activation; Glutathione; Liver Diseases; Male; Methionine Sulfoximine; Mice; Phosphorylase a; Phosphorylases; Protein Binding | 1988 |
Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cysteine; Drug Therapy; Glutathione; Liver; Methionine Sulfoximine; Mice; Prodrugs; Rats; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1987 |
Role of glutathione turnover in drug sulfation: differential effects of diethylmaleate and buthionine sulfoximine on the pharmacokinetics of acetaminophen in the rat.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Glutathione; Kidney; Kinetics; Male; Maleates; Metabolic Clearance Rate; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Sulfates | 1986 |
Hepatocytes in primary culture become susceptible to paracetamol injury after depletion of glutathione using DL-buthionine-SR-sulphoximine (BSO).
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cells, Cultured; Glutathione; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1985 |
The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation.
Topics: Acetaminophen; Animals; Biotransformation; Buthionine Sulfoximine; Glutamate-Cysteine Ligase; Glutathione; In Vitro Techniques; Male; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
Mechanism of action of paracetamol protective agents in mice in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Buthionine Sulfoximine; Cysteamine; Cysteine; Glutathione; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
A protective effect of glutathione-dextran macromolecular conjugates on acetaminophen-induced hepatotoxicity dependent on molecular size.
Topics: Acetaminophen; Animals; Antimetabolites; Aspartate Aminotransferases; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyanogen Bromide; Delayed-Action Preparations; Dextrans; Disease Models, Animal; Drug Delivery Systems; Glutathione; In Vitro Techniques; Injections, Intravenous; Liver; Liver Diseases; Male; Methionine Sulfoximine; Mice; Molecular Weight; Survival Rate | 1994 |
Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Dithiothreitol; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Mice; Sulfhydryl Compounds | 1994 |
Simultaneous measurements of glutathione and activated sulphate (PAPS) synthesis rates and the effects of selective inhibition of glutathione conjugation or sulphation of acetaminophen.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cells, Cultured; Female; Glutathione; Liver; Methionine Sulfoximine; Nitrophenols; Phosphoadenosine Phosphosulfate; Rats; Rats, Wistar; Sulfates; Sulfotransferases | 1993 |
Toxicity of paracetamol in cultured chick hepatocytes treated with methotrexate.
Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfoximine; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Glutathione; Liver; Methionine Sulfoximine; Methotrexate | 1993 |
Glutathione depletion induces glycogenolysis dependent ascorbate synthesis in isolated murine hepatocytes.
Topics: Acetaminophen; Animals; Ascorbic Acid; Bucladesine; Buthionine Sulfoximine; Cyclic AMP; Diamide; Fructose; Glutathione; Glycogen; Liver; Male; Methionine Sulfoximine; Mice; Sugar Acids; Uridine Diphosphate Glucose; Vitamin K | 1996 |
Glutathione depletion by xenobiotics in Coturnix coturnix japonica.
Topics: Acetaminophen; Animals; Brain; Buthionine Sulfoximine; Coturnix; Female; Glutathione; Kidney; Liver; Maleates; Xenobiotics | 1998 |
Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Carbon Tetrachloride; Gene Expression Regulation; Genes, fos; Genes, jun; Glutamate-Cysteine Ligase; Liver; Male; Maleates; Mice; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1 | 2000 |
Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice.
Topics: Acetaminophen; Aging; Animals; Buthionine Sulfoximine; Cysteine; Glutathione; Kidney Cortex; Liver; Male; Mice; Mice, Inbred C57BL | 2000 |
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.
Topics: Acetaminophen; Acetylation; Alanine Transaminase; Aminophenols; Animals; Ascorbic Acid; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cysteine; Cystine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Glutathione Disulfide; L-Iditol 2-Dehydrogenase; Liver; Male; Mice; Mice, Inbred C57BL | 2001 |
Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of p450 2E1-related cytotoxicity.
Topics: Acetaminophen; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Division; Cell Line, Transformed; Cell Survival; Cytochrome P-450 CYP2E1; Ethanol; Gene Expression; Humans; Liver Neoplasms; Tumor Cells, Cultured | 2000 |
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Animal; Drug Synergism; Glutathione; Hepatic Encephalopathy; Injections, Intravenous; Injections, Subcutaneous; Liver; Liver Failure; Male; Methylcholanthrene; Phenobarbital; Rabbits | 2002 |
A novel model of continuous depletion of glutathione in mice treated with L-buthionine (S,R)-sulfoximine.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Buthionine Sulfoximine; Creatinine; Drug Synergism; Glutathione; Liver; Male; Mice; Mice, Inbred Strains; Models, Animal; Organ Size; Toxicity Tests; Water | 2003 |
Evaluation of glutathione deficiency in rat livers by microarray analysis.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Butylated Hydroxyanisole; Gene Expression Profiling; Glutathione; Liver; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; In Vitro Techniques; Kidney; Kidney Diseases; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Prodrugs; Protective Agents; Thiazoles; Thiazolidines | 2005 |
Transport deficient (TR-) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Cytochrome P-450 Enzyme System; Glutathione; Hyperbilirubinemia; Liver; Male; Multidrug Resistance-Associated Proteins; Rats; Rats, Wistar; RNA, Messenger | 2005 |
Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Fabaceae; Flavanones; Glucosides; L-Lactate Dehydrogenase; Liver; Molecular Structure; Rats; Rats, Sprague-Dawley | 2006 |
Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Buthionine Sulfoximine; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytoplasm; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutamate-Cysteine Ligase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2010 |
Acetaminophen-induced cytotoxicity on human normal liver L-02 cells and the protection of antioxidants.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Buthionine Sulfoximine; Cell Line; Cytochrome P-450 CYP2E1; Humans; Liver; Oxidative Stress | 2010 |
Glutathione modulation and oxidative stress in human liver slices.
Topics: Acetaminophen; Adenosine Triphosphate; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Gene Expression; Glutathione; Humans; In Vitro Techniques; Liver; Methimazole; Mitochondria; Oxidation-Reduction; Oxidative Stress | 2010 |
In vitro cytotoxicity assay to evaluate the toxicity of an electrophilic reactive metabolite using glutathione-depleted rat primary cultured hepatocytes.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cells, Cultured; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Glutathione; Hepatocytes; Rats; Risk; Toxicity Tests | 2010 |
Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Buthionine Sulfoximine; Disease Susceptibility; Female; Glutamate-Cysteine Ligase; Glutathione; Liver; Male; Mice; Multidrug Resistance-Associated Proteins; RNA, Messenger; Sex Characteristics | 2011 |
Nerve growth factor exhibits an antioxidant and an autocrine activity in mouse liver that is modulated by buthionine sulfoximine, arsenic, and acetaminophen.
Topics: Acetaminophen; Animals; Antioxidants; Arsenic; Autocrine Communication; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Liver; Mice; Nerve Growth Factor; Neurons; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Phosphorylation; Rats; Receptor, trkA | 2013 |
Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system.
Topics: Acetaminophen; Adenosine Triphosphate; Albumins; Analgesics, Non-Narcotic; Animals; Buthionine Sulfoximine; Coculture Techniques; Cytochrome P-450 CYP3A; Dexamethasone; Dose-Response Relationship, Drug; Fibroblasts; Glutathione; Hepatocytes; Male; Models, Biological; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Up-Regulation; Urea | 2013 |
Evaluation of hepatic damage by reactive metabolites--with consideration of circadian variation of murine hepatic glutathione levels.
Topics: Acetaminophen; Administration, Oral; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Disease Models, Animal; Glutathione; Liver; Male; Mice, Inbred BALB C; Osmosis; Time Factors; Water | 2014 |
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Fibroblasts; Hepatocytes; Humans; Liver; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Wharton Jelly | 2022 |