acetaminophen and bilirubin

acetaminophen has been researched along with bilirubin in 141 studies

Research

Studies (141)

TimeframeStudies, this research(%)All Research%
pre-199043 (30.50)18.7374
1990's12 (8.51)18.2507
2000's29 (20.57)29.6817
2010's44 (31.21)24.3611
2020's13 (9.22)2.80

Authors

AuthorsStudies
Strassburg, CP; Tukey, RH1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Glen, RC; Lowe, R; Mitchell, JB1
Douglas, AP; Hamlyn, AN; James, O1
Siegers, CP1
Hart, FE; Willson, RA1
Brunner, G; Büttelmann, B; Holloway, CJ; Husmann, S; Lösgen, H; Scharff, P; Siehoff, A1
Arnman, R; Olsson, R1
Davis, M; Gazzard, BG; Goulding, R; Hughes, RD; Widdop, B; Williams, R1
Davidson, AR; Rojas-Bueno, A; Thompson, RP; Williams, R1
Gazzard, BG; Henderson, JM; Williams, R1
Duncan, JR; Finco, DC; Prasse, KW; Schall, WD1
Khanna, NN; Levy, G; Soda, DM; Stern, L; Tsuzuki, O1
Davis, M; Harrison, NG; Ideo, G; Williams, R1
Davidson, AR; Day, DW; Murray-Lyon, IM; Portmann, B; Talbot, IC; Williams, R1
Funk, C; Knoblauch, M; Lämmli, J1
Avramova, K; Goranov, I1
Dutkiewicz, T; Juzwiak, S; Juzyszyn, Z; Krasowska, B; Olenderek, B; Raińska, T; Roźéwicka, L; Samochowiec, L; Wójcicki, J1
Sherman, SE; Watkins, JB1
Hughes, RD; Langley, PG; Rolando, N; Williams, R1
Ebong, PE; Udosen, EO1
Beckett, GJ; Donovan, JW; Hussey, AJ; Prescott, LF; Proudfoot, AT1
Ebong, PE; Ekanemessang, UM; Udosen, EO1
Bock, KW; Bock-Hennig, BS1
Goldstein, RS; Hook, JB; Morgan, DG; Tarloff, JB1
Bircher, J; Blume, R; Bock, KW; Schröter, W; Sieg, A; Ullrich, D1
de Morais, SM; Wells, PG1
Artwohl, JE; Carter, E; Cera, LM; Henne-Bruns, D1
Campbell, RJ; Hall, LJ; Halpin, TJ; Holtzhauer, FJ1
Brown, SS; Prescott, LF; Roscoe, P; Wright, N1
Borirakchanyavat, V; Clark, R; Davidson, AR; Goulding, R; Thompson, RP; Widdop, B; Williams, R1
Forrest, AR; Matthew, H; Newton, RW; Prescott, LF; Swainson, CP; Wright, N1
Matthew, H; Newton, RW; Prescott, LF1
Forrest, JA; Prescott, LF; Roscoe, P; Stevenson, IH1
Clark, R; Flute, PT; Rake, MO; Williams, R1
Chakrabarti, AK; Lloyd, GH1
Prescott, LF; Wrights, N1
Matthew, H1
Borirakchanyavat, V; Clark, R; Flute, PT; Gazzard, BG; Rake, MO; Shilkin, KB; Williams, R1
Gault, MH; Hebert, MA; Singh, HP1
Windorfer, A1
Adjukiewicz, AB; Chalstrey, LJ; Hillenbrand, P; James, IM; Kennedy, J; Parbhoo, SP1
De la Tour, J; Debray, C; Roze, C; Souchard, M; Vaille, C1
Ertel, IJ; Levy, G1
Carroll, JD; Stephens, JD; Toghill, PJ; Williams, R1
Linden, CH; Rumack, BH1
Fysh, WJ; Gamsu, HR; Lederman, S; Tredger, M1
Foster, MG; Wright, LA1
Hilligoss, D; Kellmeyer, K; Parker, S; Yates, C1
Wardle, EN; Williams, R1
Carracio, TR; Mofenson, HC; Singer, AJ1
Daikuhara, Y; Hughes, RD; Tsubouchi, H; Williams, R; Zhang, L1
Doyle, S; Rees, GW; Trull, AK1
Mishra, SH; Rao, KS1
Andrade, RJ; Camargo, R; García-Escaño, MD; Lucena, MI1
Lozano Cortés, M; Meléndez Camargo, ME1
Ishii, H; Ishimura, Y; Kyokane, T; Mori, M; Sano, T; Suematsu, M; Suzuki, H; Yamaguchi, T1
Kumar, CK; Maiti, BC; Mandal, SC; Mohana Lakshmi, S; Saraswathi, B1
Bengochea, L; Ghanem, C; Ghisolfi, C; Lemberg, A; Perazzo, JC; Scorticati, C1
Batlle, AM; Noriega, GO; Ossola, JO; Tomaro, ML1
Abe, T; Aoki, M; Horiuchi, R; Ishibashi, M; Matsuo, T; Mitsuhashi, H; Ohno, S; Saito, K; Saito, T; Shinzawa, H; Sugahara, K; Takahashi, T; Terui, Y; Togashi, H; Watanabe, H; Yamada, N1
Banerjee, S; Bhakta, T; Maity, TK; Mandal, SC; Pal, M; Saha, BP1
Bazooband, A; Bertholf, RL; Johannsen, LM; Mansouri, V1
DESFORGES, J; GELLIS, S; SILVERBERG, M1
Han, J; He, P; Li, XD; Lv, Y; Wu, MC; Xia, SQ1
Kuhlmann, J; Rauchschwalbe, SK; Wensing, G; Zühlsdorf, MT1
Devaki, T; Ravikumar, V; Shivashangari, KS1
Evans, RM; Huang, W; Moore, DD; Qatanani, M; Zhang, J1
Beuhler, MC; Curry, SC1
Ciszowski, K; Gomółka, E; Jenner, B1
Davies, P; Kelly, DA; Mahadevan, SB; McKiernan, PJ1
Boujaoude, J; Honein, K; Moucari, R; Sayegh, R; Slim, R; Yaghi, C1
Chantharaksri, U; Fucharoen, P; Fucharoen, S; Howard, TA; Morales, NP; Sanvarinda, Y; Sirankapracha, P; Tankanitlert, J; Temsakulphong, A; Ware, RE1
Akinwande, AI; Alabi-Sofunde, JA; Efedede, BU; Iwalokun, BA; Magbagbeola, OA; Oduala, T1
Bogdan, GM; Dart, RC; Green, JL; Heard, K; Knox, PC; Kuffner, EK; Palmer, RB; Slattery, JT1
Balko, JA; Fuller, D; Hynan, LS; Khan, AI; Koff, JM; Lee, WM; Murray, NG; Orsulak, P; Polson, J; Wians, FH1
Bahr, MJ; Hadem, J; Klempnauer, J; Manns, MP; Rifai, K; Schneider, AS; Stiefel, P; Tillmann, HL; Wedemeyer, H1
Etani, Y; Mushiake, S; Nakayama, M; Ozono, K; Tajiri, H1
Bhadauria, M; Nirala, SK1
Adukauskiene, D; Dockiene, I; Kevelaitis, E; Kupcinskas, L; Naginiene, R; Pundzius, J1
Nwanna, EE; Oboh, G1
Kumar, RS; Rajesh, SV; Rajkapoor, B; Raju, K1
Ancy, P; Anuja, GI; Latha, PG; Rajasekharan, S; Shine, VJ; Shyamal, S; Sini, S; Sreedevi, CD; Suja, SR1
Allegaert, K; van den Anker, JN; Vanhaesebrouck, S; Verbesselt, R1
Bala, U; Garba, SH; Sambo, N1
Das, AK; Roy, CK1
Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH1
Avizeh, R; Najafzadeh, H; Razijalali, M; Shirali, S1
Firdous, AP; Kuttan, R; Preethi, KC; Sindhu, ER1
Fong, BM; Siu, TS; Tam, S1
Lee, WM1
Bertholf, RL1
James, LP; Khandelwal, N; Larson, AM; Lee, WM; Sanders, C1
Raja, B; Ramachandran, V1
Firdous, AP; Kuttan, R; Sindhu, ER1
Li, RS; Shan, LM; Wang, JB; Xiao, XH; Yang, HB; Zhao, YL; Zhou, GD1
Kavsak, PA; Zeidler, J1
Chandrasekharan, DK; Menon, A; Nagalekshmi, R; Nair, CK1
Nwaehujor, CO; Udeh, NE1
Chen, Y; Jothy, SL; Latha, LY; Nithianantham, K; Sasidharan, S; Shyamala, M1
Ashok, P; Madhavan, V; Murali, A1
Chen, Y; Grace-Lynn, C; Jothy, SL; Kanwar, JR; Latha, LY; Sasidharan, S; Vijayarathna, S1
Sathya, A; Siddhuraju, P1
Kiran, PM; Raju, AV; Rao, BG1
Alipour, M; Buonocore, C; Omri, A; Pucaj, K; Suntres, ZE; Szabo, M1
Dygai, AM; Udut, VV; Vengerovsky, AI1
Brito, MV; Teixeira, RK; Yamaki, VN; Yasojima, EY1
Abdel-Azeem, AS; El-Sayed, EM; Farrag, AR; Hegazy, AM; Ibrahim, KS1
Abo-Elmatty, DM; Aly, HF; Desoky, MM; Ibrahim, N; Rizk, MZ; Younis, EA1
Li, W; Pu, XP; Sun, H; Sun, Y; Wang, YH; Yang, YF; Zhao, X; Zheng, XY1
He, Y; Hu, JF; Hu, X; Li, C; Li, T; Liu, M; Liu, Z; Meng, F; Mrsny, RJ; Zeng, X; Zhou, X1
Aba, PE; Ozioko, IE; Udem, ND; Udem, SC1
Chong, YK; Lam, HL; Lau, MH; Leung, DC; Mak, CM1
Chen, YH; Ji, LL; Jiang, P; Sheng, YC; Wang, ZT1
Brito, MV; Costa, FD; Costa, LA; Teixeira, RK; Vasconcelos, DM; Yamaki, VN; Yasojima, EY1
Itoh, S; Kusaka, T; Okada, H; Sugino, M1
Ahmad, A; Kushwah, DS; Salman, MT; Singh, P; Verma, VK1
Ajiboye, TO1
Cardinale, M; Craft, J; Meyers, R1
Abd El-Ghffar, EA; El-Nashar, HA; Eldahshan, OA; Singab, AN1
Ho, HY; Huang, GJ; Huang, SS; Jiang, WP; Matsuda, Y; Saito, H; Uramaru, N; Wu, JB1
Cai, L; Cheng, Y; Feng, L; Gao, Y; He, GL; Jiang, ZS; Pan, MX; Zhou, CJ1
Ahmad, M; Akhtar, N; Asif, HM; Rehman, J; Sultana, S1
Antoine, DJ; Brillant, N; Burton, NC; Elmasry, M; Fenwick, S; Goldring, CE; Kipar, A; Kitteringham, NR; Park, BK; Poptani, H; Rodriguez, JM; Sharkey, JW1
Asai, Y; Katoh, M; Nadai, M; Onouchi, H; Sakakibara, Y1
Aka, C; Koca-Caliskan, U; Sekeroglu, N; Taslidere, A; Yalcin, FN; Yilmaz, I1
Chan, BY; Lee, HH; Leung, DC; Ling, WH; Mak, CM; Ng, CW; Tsang, HM1
Ahmed, AAH; Ahmed, AM; Al-Matrafi, TA; Al-Saggaf, S; Alqahtani, HM; AlRabiah, A; Arafah, MM; Atteya, M; Mohammad, RAT; Shereef, SH1
Asai, S; Ichimura, S; Kakita, H; Kondo, T; Mori, M; Ohashi, W; Okumura, A; Takeshita, S; Ueda, H; Yamada, Y1
Ali, ES; Asha, UH; Islam, MA; Islam, MT; Kamal, RM; Kumar, M; Mondal, M; Quispe, C; Razis, AFA; Saha, S; Sharifi-Rad, J; Sunusi, U1
Bellomo, R; Gow, P; Holmes, N; Kishore, K; Marhoon, N; Michel, C; Serpa Neto, A; Sinclair, M; Testro, A; Warming, S; Warrillow, S1
Hagimoto, S; Iwatani, S; Tamaki, S; Yoshimoto, S1
Akpulat, HA; Ataseven, H; Filiz, AK; Gezer, A; Karabulut, S; Özkaraca, M; Sahin, B1
Menisy, GM; Suddek, GM; Zakaria, S1
Afroze, M; Al-Khafaji, K; Araújo, IM; Asha, UH; Coutinho, HDM; de Lacerda, BCGV; El-Kersh, DM; Islam, MT; Jamaddar, S; Khalipha, ABR; Khan, M; Mondal, M; Moniruzzaman, M; Mori, E; Ray, P; Roy, UK; Sarkar, C; Shill, MC1
Bai, ZF; Dai, WZ; He, TT; Li, Q; Xiao, XH; Zhan, XY; Zhao, J1
Hijikata, M; Imaizumi, T; Katayama, D; Morioka, I; Nagano, N; Okahashi, A; Tsuji, Y1
Ayenew, KD; Wasihun, Y1
Chen, R; Dai, S; Huang, H; Huang, L; Jiang, X; Jiang, Z; Kou, L; Lin, G; Lu, R; Sun, M; Sun, T; Tang, Y; Xu, Y; Yao, Q; Yao, X; Zheng, S1
Avachat, C; Barry, JM; Birnbaum, AK; Brink Henriksen, T; Christensen, U; Dalhoff, K; Haslund-Krog, S; Holst, H; Poulsen, S; Remmel, RP; Sherwin, CMT; van den Anker, JN; Wilkins, D1
Ahmad, S; Ansari, MA; Aslam, M; Chaudhary, SS; Siddiqui, A; Sumaiya, S1

Reviews

2 review(s) available for acetaminophen and bilirubin

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
Acetaminophen overdose.
    Emergency medicine clinics of North America, 1984, Volume: 2, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Cysteine; Dose-Response Relationship, Drug; Glutathione; History, 20th Century; Humans; Kinetics; Liver Diseases; Prognosis; Prothrombin Time; Time Factors

1984

Trials

4 trial(s) available for acetaminophen and bilirubin

ArticleYear
Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning.
    Lancet (London, England), 1976, Jan-17, Volume: 1, Issue:7951

    Topics: Acetaminophen; Acute Disease; Adult; Age Factors; Aged; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Clinical Trials as Topic; Cysteamine; Ferritins; Humans; Injections, Intravenous; Liver; Liver Function Tests; Prothrombin; Time Factors

1976
Early changes in coagulation following a paracetamol overdose and a controlled trial of fresh frozen plasma therapy.
    Gut, 1975, Volume: 16, Issue:8

    Topics: Acetaminophen; Adult; Aspartate Aminotransferases; Bilirubin; Blood Coagulation; Clinical Trials as Topic; Factor V; Factor VII; Fibrinogen; Humans; Infusions, Parenteral; Liver; Plasma; Prothrombin; Prothrombin Time; Substance-Related Disorders; Temperature; Time Factors

1975
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
    BMC medicine, 2007, May-30, Volume: 5

    Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Bilirubin; Female; Fever; Glutathione; Humans; International Normalized Ratio; Liver Diseases, Alcoholic; Male; Middle Aged; Pain; Risk Assessment; Temperance

2007
Evaluation of prophylactic and therapeutic effects of silymarin and N-acetylcysteine in acetaminophen-induced hepatotoxicity in cats.
    Journal of veterinary pharmacology and therapeutics, 2010, Volume: 33, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Animals; Bilirubin; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Liver; Male; Methemoglobinemia; Protective Agents; Silymarin

2010

Other Studies

135 other study(ies) available for acetaminophen and bilirubin

ArticleYear
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Influence of dithiocarb on the biliary excretion of paracetamol and bilirubin in rats.
    Experientia, 1978, Oct-15, Volume: 34, Issue:10

    Topics: Acetaminophen; Animals; Bile; Bilirubin; Ditiocarb; Glucuronates; Male; Rats; Thiocarbamates

1978
Effect of experimental hepatic injury on in vitro drug-metabolizing enzyme activities in the rat.
    Gastroenterology, 1977, Volume: 73, Issue:4 Pt 1

    Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Bilirubin; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Glucuronosyltransferase; In Vitro Techniques; Liver; Liver Cirrhosis, Experimental; Male; Microsomes, Liver; Rats

1977
Large agarose beads for extracorporeal detoxification systems.
    Biomaterials, medical devices, and artificial organs, 1978, Volume: 6, Issue:2

    Topics: Acetaminophen; Animals; Bilirubin; Carrier Proteins; Ethanolamines; Hemoperfusion; Hepatic Encephalopathy; Humans; Hyperbilirubinemia; Phenols; Polysaccharides; Rabbits; Sepharose; Serum Albumin

1978
Elimination of paracetamol in chronic liver disease.
    Acta hepato-gastroenterologica, 1978, Volume: 25, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Bilirubin; Humans; Liver Cirrhosis; Liver Neoplasms; Middle Aged

1978
Early prediction of the outcome of a paracetamol overdose based on an analysis of 163 patients.
    Postgraduate medical journal, 1977, Volume: 53, Issue:619

    Topics: Acetaminophen; Bilirubin; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver Diseases; Liver Function Tests; Prognosis

1977
Early unconjugated hyperbilirubinaemia after paracetamol overdosage.
    Scandinavian journal of gastroenterology, 1976, Volume: 11, Issue:6

    Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Humans; Hyperbilirubinemia; Liver; Male; Rats

1976
Acetaminophen toxicosis in the cat.
    Journal of the American Veterinary Medical Association, 1975, Mar-01, Volume: 166, Issue:5

    Topics: Acetaminophen; Administration, Oral; Anemia; Animals; Bilirubin; Blood Urea Nitrogen; Cat Diseases; Cats; Cyanosis; Dehydration; Edema; Face; Female; Fever; Hemoglobinuria; Jaundice; Male

1975
Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion.
    Pediatrics, 1975, Volume: 55, Issue:6

    Topics: Acetaminophen; Adipates; Age Factors; Bilirubin; Body Weight; Female; Glucuronates; Half-Life; Humans; Infant, Newborn; Kinetics; Liver; Male; Pregnancy; Sugar Acids; Sulfates

1975
Early inhibition of hepatic bilirubin conjugation after paracetamol (acetaminophen) administration in the rat.
    Digestion, 1975, Volume: 13, Issue:1-2

    Topics: Acetaminophen; Animals; Bilirubin; Liver; Male; Rats; Time Factors

1975
Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters.
    The Journal of pathology, 1975, Volume: 117, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Middle Aged; Necrosis; Prothrombin Time

1975
[Drug-induced liver diseases].
    Gastroenterologische Fortbildungskurse fur die Praxis, 1975, Volume: 5

    Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Dihydroxyphenylalanine; Enzyme Induction; Fatty Liver; Female; Granuloma; Halothane; Hepatomegaly; Humans; Male; Middle Aged; Oxyphenisatin Acetate; Pregnancy; Sulfonamides; Tetracycline

1975
[Study of liver glucuronidase function in indirect hyperbilirubinemia and liver cirrhosis].
    Problemi na khigienata, 1975, Volume: 1

    Topics: Acetaminophen; Bilirubin; Biological Transport; Free Radicals; Glucuronidase; Humans; Hyperbilirubinemia; Jaundice; Liver; Liver Cirrhosis

1975
Caffeine reduces the hepatotoxicity of paracetamol in mice.
    The Journal of international medical research, 1992, Volume: 20, Issue:4

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Bilirubin; Caffeine; Glutathione; Liver; Male; Mice; Mice, Inbred BALB C

1992
Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: Acetaminophen; Animals; Bile; Bilirubin; Diabetes Mellitus, Experimental; Digoxin; Glucuronates; Insulin; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Sulfates

1992
Increased elastase-alpha 1-antitrypsin complex in fulminant hepatic failure: relationship to bacterial infection and activation of coagulation.
    Clinica chimica acta; international journal of clinical chemistry, 1991, Aug-30, Volume: 200, Issue:2-3

    Topics: Acetaminophen; alpha 1-Antitrypsin; Aspartate Aminotransferases; Bacterial Infections; Bilirubin; Blood Coagulation; Creatinine; Drug Overdose; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis, Viral, Human; Humans; Liver Diseases; Male; Neutrophils; Pancreatic Elastase; Prothrombin Time; Renal Dialysis; Treatment Outcome

1991
The effect of prolonged exposure of rats to sub-lethal dose of acetaminophen.
    The Central African journal of medicine, 1991, Volume: 37, Issue:4

    Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Drug Evaluation, Preclinical; Liver Function Tests; Male; Methemoglobinemia; Rats

1991
Intravenous N-acetylcysteine, hepatotoxicity and plasma glutathione S-transferase in patients with paracetamol overdosage.
    Human & experimental toxicology, 1990, Volume: 9, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Glutathione Transferase; Humans; Infusions, Intravenous; Male; Middle Aged

1990
Hepatoxicity evaluation in rats given a single overdose of Acetaminophen (Paracetamol).
    The Central African journal of medicine, 1989, Volume: 35, Issue:10

    Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Methemoglobinemia; Rats

1989
Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers.
    Biochemical pharmacology, 1987, Dec-01, Volume: 36, Issue:23

    Topics: Acetaminophen; Adolescent; Adult; Benzopyrenes; Bilirubin; Carcinoma, Hepatocellular; Enzyme Induction; Female; Glucuronosyltransferase; Humans; Hydroquinones; Hymecromone; Isoenzymes; Liver Neoplasms; Male; Methylcholanthrene; Microsomes, Liver; Middle Aged; Naphthols; Pentobarbital; Phenytoin; Tumor Cells, Cultured

1987
Acetaminophen and p-aminophenol nephrotoxicity in aging male Sprague-Dawley and Fischer 344 rats.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 12, Issue:1

    Topics: Acetaminophen; Aging; Aminophenols; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Kidney; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Male; Organ Size; Rats; Rats, Inbred F344; Rats, Inbred Strains

1989
Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome.
    European journal of clinical investigation, 1987, Volume: 17, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Female; Gilbert Disease; Glucuronates; Humans; Hyperbilirubinemia, Hereditary; Male; Oxidation-Reduction; Sulfates

1987
Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1

    Topics: Acetaminophen; Age Factors; Alanine Transaminase; Animals; Bilirubin; Biotransformation; Blood Urea Nitrogen; Glucuronosyltransferase; Liver; Male; Rats; Rats, Gunn; Rats, Inbred Strains; Species Specificity; Sulfates

1988
Acetaminophen toxicosis: a potential model for acute liver failure in swine.
    Veterinary and human toxicology, 1988, Volume: 30, Issue:4

    Topics: Acetaminophen; Acute Disease; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Liver; Male; Swine

1988
Reye's syndrome. An epidemiologic analysis of mild disease.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:12

    Topics: Acetaminophen; Ammonia; Aspirin; Bilirubin; Female; Humans; Male; Reye Syndrome

1986
Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage.
    Lancet (London, England), 1971, Mar-13, Volume: 1, Issue:7698

    Topics: Acetaminophen; Adolescent; Adult; Aged; Bilirubin; Humans

1971
Hepatic damage and death from overdose of paracetamol.
    Lancet (London, England), 1973, Jan-13, Volume: 1, Issue:7794

    Topics: Acetaminophen; Adolescent; Adult; Aspartate Aminotransferases; Bilirubin; Biopsy; Blood Coagulation Tests; Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Middle Aged; Prothrombin Time; Time Factors

1973
Successful treatment of severe paracetamol overdosage with cysteamine.
    Lancet (London, England), 1974, Apr-06, Volume: 1, Issue:7858

    Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Blood Cell Count; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Cysteamine; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Liver Diseases; Middle Aged; Poisoning; Prothrombin Time; Spectrophotometry; Suicide

1974
Letter: Treatment of paracetamol overdosage.
    Lancet (London, England), 1974, Jul-27, Volume: 2, Issue:7874

    Topics: Acetaminophen; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; L-Lactate Dehydrogenase

1974
Abnormal drug metabolism after barbiturate and paracetamol overdose.
    British medical journal, 1974, Nov-30, Volume: 4, Issue:5943

    Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Amobarbital; Antipyrine; Barbiturates; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Half-Life; Humans; Liver; Male; Middle Aged; Necrosis

1974
Coagulation abnormalities in acute liver failure; pathogenetic and therapeutic implications.
    Scandinavian journal of gastroenterology. Supplement, 1973, Volume: 19

    Topics: Acetaminophen; Acute Disease; Bilirubin; Biopsy; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Transfusion; Chemical and Drug Induced Liver Injury; Disseminated Intravascular Coagulation; Fibrinogen; Hemorrhage; Heparin; Humans; Iodine Radioisotopes; Liver Diseases; Prothrombin Time

1973
Gross paracetamol overdosage with recovery.
    The Practitioner, 1973, Volume: 210, Issue:257

    Topics: Acetaminophen; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Male; Necrosis; Prednisolone; Transaminases

1973
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
    Scottish medical journal, 1973, Volume: 18, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Drug Synergism; Ethanol; Female; Half-Life; Humans; Hydroxybutyrate Dehydrogenase; Imipramine; L-Lactate Dehydrogenase; Liver Diseases; Male; Middle Aged; Necrosis; Phenobarbital

1973
Acute acetaminophen poisoning.
    Clinical toxicology, 1973, Volume: 6, Issue:1

    Topics: Acetaminophen; Bilirubin; Blood Coagulation Disorders; Cardiomyopathies; Diuresis; Humans; Hypoglycemia; Kidney Diseases; Liver Diseases; Necrosis; Poisoning; Renal Dialysis

1973
Disorderd hemostasis in liver damage from paracetamol overdose.
    Gastroenterology, 1973, Volume: 65, Issue:5

    Topics: Acetaminophen; Adult; Bilirubin; Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Chemical and Drug Induced Liver Injury; Female; Fibrin; Fibrinogen; Fibrinolysis; Hemostasis; Hepatic Encephalopathy; Humans; Iodine Radioisotopes; Liver Diseases; Liver Function Tests; Male; Middle Aged; Plasminogen; Prothrombin Time

1973
Effect of some drugs on clinical laboratory values as determined by the Technicon SMA 12-60.
    Clinical chemistry, 1972, Volume: 18, Issue:2

    Topics: Acetaminophen; Alkaline Phosphatase; Aminosalicylic Acids; Ascorbic Acid; Aspartate Aminotransferases; Autoanalysis; Bilirubin; Blood Chemical Analysis; Blood Glucose; Chemical Phenomena; Chemistry; Cholesterol; Clinical Laboratory Techniques; Dihydroxyphenylalanine; Evaluation Studies as Topic; Humans; Isoniazid; L-Lactate Dehydrogenase; Mercaptopurine; Methyldopa; Pharmaceutical Preparations; Spectrophotometry; Sulfathiazoles; Uric Acid

1972
[Increased rate of glucuronidation in the human and animal newborn by therapeutic doses of phenobarbital].
    Zeitschrift fur Kinderheilkunde, 1972, Volume: 113, Issue:1

    Topics: Acetaminophen; Administration, Oral; Animals; Animals, Newborn; Bilirubin; Biotransformation; Chromatography, Gas; Enzyme Induction; Evaluation Studies as Topic; Female; Glucuronates; Hexosyltransferases; Humans; Infant, Newborn; Metabolic Clearance Rate; Phenobarbital; Pregnancy; Rabbits; Time Factors

1972
Extracorporeal perfusion of pig liver in the treatment of acute liver failure.
    The British journal of surgery, 1971, Volume: 58, Issue:10

    Topics: Acetaminophen; Adult; Animals; Bilirubin; Brain; Chemical and Drug Induced Liver Injury; Electroencephalography; Fatty Liver; Female; Glucose; Hepatic Encephalopathy; Hepatitis A; Hepatitis B; Humans; Liver; Male; Middle Aged; Necrosis; Oxygen Consumption; Perfusion; Radionuclide Imaging; Serum Albumin; Swine; Urea

1971
[Action of an antihypertensive agent on the biliary and external pancreatic secretions of the rat].
    Revue internationale d'hepatologie, 1969, Volume: 19, Issue:6

    Topics: Acetaminophen; Animals; Antihypertensive Agents; Bile; Bilirubin; Blood Glucose; Catecholamines; Diazoxide; Epinephrine; Injections, Intravenous; Insulin; Pancreatic Juice; Rats; Respiration

1969
Effect of bilirubin on drug conjugations in children.
    Pediatrics, 1971, Volume: 47, Issue:5

    Topics: Acetaminophen; Adult; Bilirubin; Biological Transport, Active; Biotransformation; Child; Female; Glucuronates; Humans; Hyperbilirubinemia, Hereditary; Liver; Oxidative Phosphorylation; Phenobarbital; Salicylamides; Salicylates; Transferases

1971
Acute hepatic necrosis following an overdose of paracetamol.
    Gastroenterology, 1969, Volume: 56, Issue:4

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Bilirubin; Blood Glucose; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Necrosis; Plasma; Substance-Related Disorders; Suicide; Urea

1969
Neonatal paracetamol poisoning: treatment by exchange transfusion.
    Archives of disease in childhood, 1983, Volume: 58, Issue:8

    Topics: Acetaminophen; Adult; Aspartate Aminotransferases; Bilirubin; Exchange Transfusion, Whole Blood; Female; Humans; Infant, Newborn; Pregnancy; Prothrombin Time

1983
Effect of some commonly prescribed drugs on certain chemistry tests.
    Clinical biochemistry, 1980, Volume: 13, Issue:6

    Topics: Acetaminophen; Ascorbic Acid; Aspartate Aminotransferases; Aspirin; Bilirubin; Blood Chemical Analysis; Blood Glucose; Calcium; Carbon Dioxide; Cholesterol; Humans; Methyldopa; Nitrofurantoin; Pharmacology; Tetracycline; Uric Acid

1980
Bilirubin interference with kit determination of acetaminophen.
    Clinical chemistry, 1982, Volume: 28, Issue:3

    Topics: Acetaminophen; Bilirubin; Humans; Reagent Kits, Diagnostic

1982
Raised serum biliverdin in hepatic necrosis.
    Biochemical medicine, 1981, Volume: 26, Issue:1

    Topics: Acetaminophen; Animals; Bile Acids and Salts; Bilirubin; Biliverdine; Chemical and Drug Induced Liver Injury; Cholestasis; Galactosamine; Humans; Liver; Liver Diseases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats

1981
The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction.
    Annals of emergency medicine, 1995, Volume: 26, Issue:1

    Topics: Acetaminophen; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Poisoning; Prospective Studies; Prothrombin Time; Time Factors

1995
Plasma hepatocyte growth factor and biliprotein levels and outcome in fulminant hepatic failure.
    Journal of hepatology, 1994, Volume: 20, Issue:1

    Topics: Acetaminophen; Adult; Bilirubin; Enzyme-Linked Immunosorbent Assay; Female; Hepatic Encephalopathy; Hepatocyte Growth Factor; Humans; Liver Regeneration; Liver Transplantation; Male

1994
Evaluation of an enzyme-immunometric assay for serum alpha-glutathione S-transferase.
    Annals of clinical biochemistry, 1995, Volume: 32 ( Pt 6)

    Topics: Acetaminophen; Alkaline Phosphatase; Analgesics, Non-Narcotic; Analysis of Variance; Arthritis, Rheumatoid; Bilirubin; Evaluation Studies as Topic; Glutathione Transferase; Graft Rejection; Humans; Immunoenzyme Techniques; Kidney Diseases; Liver; Liver Function Tests; Liver Transplantation; Longitudinal Studies; Reagent Kits, Diagnostic; Reference Values; Reproducibility of Results; Rhabdomyolysis; Rheumatoid Factor

1995
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
    Journal of ethnopharmacology, 1998, Volume: 60, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fumarates; Galactosamine; Liver; Male; Maleates; Plant Extracts; Rats; Rats, Wistar; Rifampin; Silymarin; Thioacetamide

1998
Severe idiosyncratic acute hepatic injury caused by paracetamol.
    Journal of hepatology, 1998, Volume: 28, Issue:6

    Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Bilirubin; Bronchitis; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Roxithromycin

1998
Renal and hepatic interactions of acetaminophen and amikacin in the infant rat.
    Proceedings of the Western Pharmacology Society, 1998, Volume: 41

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Amikacin; Analgesics, Non-Narcotic; Animals; Animals, Newborn; Anti-Bacterial Agents; Bilirubin; Creatinine; Dose-Response Relationship, Drug; Drug Interactions; Female; Glucose; Kidney; Liver; p-Aminohippuric Acid; Potassium; Proteins; Rats; Rats, Wistar; Sodium

1998
Carbon monoxide-mediated alterations in paracellular permeability and vesicular transport in acetaminophen-treated perfused rat liver.
    Hepatology (Baltimore, Md.), 1999, Volume: 30, Issue:1

    Topics: Acetaminophen; Animals; Bile; Bilirubin; Carbon Monoxide; Cell Membrane Permeability; Cholestasis; Clotrimazole; Cytochrome P-450 Enzyme System; Heme Oxygenase (Decyclizing); Liver; Male; Microsomes, Liver; Perfusion; Protoporphyrins; Rats; Rats, Wistar

1999
Protective effect of leaf extract of Ficus hispida Linn. against paracetamol-induced hepatotoxicity in rats.
    Phytotherapy research : PTR, 2000, Volume: 14, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Liver; Liver Diseases; Male; Plant Extracts; Plant Leaves; Random Allocation; Rats; Rats, Wistar; Rosales

2000
[Does TNF-alpha contribute to liver disease physiopathology?].
    Acta gastroenterologica Latinoamericana, 2000, Volume: 30, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis; Kidney Diseases; Liver; Male; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2000
Effect of acetaminophen on heme metabolism in rat liver.
    The international journal of biochemistry & cell biology, 2000, Volume: 32, Issue:9

    Topics: 5-Aminolevulinate Synthetase; Acetaminophen; Animals; Bilirubin; Female; Heme; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; S-Adenosylmethionine

2000
Acute cholestatic hepatitis caused by a probable allergic reaction to paracetamol in an adolescent.
    The Tohoku journal of experimental medicine, 2001, Volume: 193, Issue:3

    Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Hypersensitivity; Female; Hepatitis, Viral, Human; Humans; Liver Function Tests; Lymphocyte Activation

2001
Hepatoprotective activity of Cassia fistula leaf extract.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, Volume: 8, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Fabaceae; Female; Hepatocytes; India; Liver; Liver Diseases; Male; Medicine, East Asian Traditional; Plant Extracts; Plant Leaves; Plants, Medicinal; Protective Agents; Rats; Rats, Wistar

2001
False-positive acetaminophen results in a hyperbilirubinemic patient.
    Clinical chemistry, 2003, Volume: 49, Issue:4

    Topics: Acetaminophen; Adolescent; Bilirubin; False Positive Reactions; Humans; Hyperbilirubinemia; Jaundice; Male

2003
MECHANISMS UNDERLYING VITAMIN K INDUCED HYPERBILIRUBINEMIA IN PREMATURE INFANTS.
    Annals of the New York Academy of Sciences, 1963, Dec-30, Volume: 111

    Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Bilirubin; Erythrocytes; Glucosephosphate Dehydrogenase; Glucuronates; Glutathione; Hemolysis; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Pharmacology; Toxicology; Vitamin K

1963
Conjugation metabolism of acetaminophen and bilirubin in extrahepatic tissues of rats.
    Life sciences, 2004, Jan-23, Volume: 74, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bilirubin; Biotransformation; Chromatography, High Pressure Liquid; Glucuronides; Histamine H2 Antagonists; Hypnotics and Sedatives; Liver Function Tests; Phenobarbital; Ranitidine; Rats; Rats, Sprague-Dawley; Sulfates

2004
Glucuronidation of acetaminophen is independent of UGT1A1 promotor genotype.
    International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Bilirubin; Genotype; Gilbert Disease; Glucuronosyltransferase; Humans; Male; Polymorphism, Genetic; Promoter Regions, Genetic

2004
Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats.
    Journal of medicinal food, 2004,Summer, Volume: 7, Issue:2

    Topics: Acanthaceae; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Cholesterol; Fatty Acids, Nonesterified; gamma-Glutamyltransferase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Methanol; Phytotherapy; Plant Extracts; Rats; Seeds; Triglycerides

2004
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.
    The Journal of biological chemistry, 2004, Nov-19, Volume: 279, Issue:47

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aryl Hydrocarbon Hydroxylases; Bile Acids and Salts; Bilirubin; Blotting, Northern; Clotrimazole; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Detergents; Dieldrin; Growth Inhibitors; Lithocholic Acid; Liver; Membrane Proteins; Mice; Mice, Knockout; Models, Biological; Oxidoreductases, N-Demethylating; Phenotype; Pregnane X Receptor; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA; Sodium; Transcription Factors

2004
False positive acetaminophen levels associated with hyperbilirubinemia.
    Clinical toxicology (Philadelphia, Pa.), 2005, Volume: 43, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bilirubin; Enzyme Multiplied Immunoassay Technique; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Hyperbilirubinemia; Reagent Kits, Diagnostic

2005
[The influence of the dose, time since ingestion and concentration of the xenobiotic on the clinical state and severity of liver damage with patients intoxicated with paracetamol].
    Przeglad lekarski, 2005, Volume: 62, Issue:6

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Liver Failure, Acute; Liver Function Tests; Male; Middle Aged; Poland; Retrospective Studies; Severity of Illness Index; Time Factors; Transaminases; Xenobiotics

2005
Paracetamol induced hepatotoxicity.
    Archives of disease in childhood, 2006, Volume: 91, Issue:7

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Blood Glucose; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Creatinine; Drug Overdose; Female; Humans; Infant; Liver; Liver Diseases; Male; Prognosis; Retrospective Studies; Risk Factors; Transaminases

2006
Influence of acetaminophen at therapeutic doses on surrogate markers of severity of acute viral hepatitis.
    Gastroenterologie clinique et biologique, 2006, Volume: 30, Issue:5

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarkers; Female; Hepatitis, Viral, Human; Humans; Male; Middle Aged; Prospective Studies; Prothrombin Time; Severity of Illness Index

2006
A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:9

    Topics: Acetaminophen; Adult; Area Under Curve; beta-Thalassemia; Bilirubin; Cysteine; Female; Glucuronosyltransferase; Humans; Male; Middle Aged

2006
Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice.
    Journal of medicinal food, 2006,Winter, Volume: 9, Issue:4

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Catalase; Chemical and Drug Induced Liver Injury; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Liver Diseases; Medicine, Traditional; Mice; Nigeria; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Leaves; Thiobarbituric Acid Reactive Substances; Vernonia

2006
False positive acetaminophen concentrations in patients with liver injury.
    Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 391, Issue:1-2

    Topics: Acetaminophen; Aged; Bilirubin; Drug Overdose; False Positive Reactions; Female; Humans; Hyperbilirubinemia; Liver Failure, Acute; Liver Function Tests; Male; Middle Aged

2008
Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2008, Volume: 6, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarkers; Budd-Chiari Syndrome; Female; Follow-Up Studies; Germany; Hepatitis B; Humans; Incidence; Lactic Acid; Liver Failure, Acute; Male; Middle Aged; Multivariate Analysis; Prognosis; Retrospective Studies; Risk Factors; ROC Curve; Survival Rate

2008
A favorable response to steroid therapy in a child with drug-associated acute vanishing bile duct syndrome and skin disorder.
    Journal of paediatrics and child health, 2008, Volume: 44, Issue:4

    Topics: Acetaminophen; Bile Acids and Salts; Bile Duct Diseases; Bilirubin; Cefdinir; Cephalosporins; Child; Erythema Multiforme; Humans; Male; Methylprednisolone; Syndrome

2008
Propolis reverses acetaminophen induced acute hepatorenal alterations: a biochemical and histopathological approach.
    Archives of pharmacal research, 2008, Volume: 31, Issue:4

    Topics: Acetaminophen; Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Antioxidants; Bilirubin; Blood Glucose; Chemical and Drug Induced Liver Injury; Cholesterol; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Glutathione; Glycogen; Hemoglobins; Kidney; Kidney Diseases; L-Lactate Dehydrogenase; Liver; Liver Diseases; Malondialdehyde; Oxidative Stress; Propolis; Rats; Rats, Sprague-Dawley; Silymarin; Transaminases

2008
Acute liver failure in Lithuania.
    Medicina (Kaunas, Lithuania), 2008, Volume: 44, Issue:7

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Bilirubin; Chemical and Drug Induced Liver Injury; Confidence Intervals; Data Interpretation, Statistical; Fatty Liver; Female; Hepatic Encephalopathy; Hepatitis; Humans; Lithuania; Liver Failure, Acute; Liver Transplantation; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pregnancy; Pregnancy Complications; Prognosis; Prospective Studies; Prothrombin; Risk Factors

2008
Antioxidant and hepatoprotective properties of polyphenol extracts from Telfairia occidentalis (fluted pumpkin) leaves on acetaminophen induced liver damage.
    Pakistan journal of biological sciences : PJBS, 2007, Aug-15, Volume: 10, Issue:16

    Topics: Acetaminophen; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Cucurbita; Flavonoids; Free Radical Scavengers; Humans; Liver; Medicine, Traditional; Nigeria; Phenols; Plant Extracts; Plant Leaves; Polyphenols; Rats; Rats, Wistar

2007
Effect of Clausena dentata (Willd.) M. Roem. against paracetamol induced hepatotoxicity in rats.
    Pakistan journal of pharmaceutical sciences, 2009, Volume: 22, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Clausena; Disease Models, Animal; gamma-Glutamyltransferase; Liver; Liver Diseases; Male; Plant Bark; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Silymarin

2009
Hepatoprotective studies on Sida acuta Burm. f.
    Journal of ethnopharmacology, 2009, Jul-15, Volume: 124, Issue:2

    Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Coumaric Acids; Hexobarbital; Liver; Male; Malvaceae; Mice; Phytotherapy; Plant Extracts; Plant Roots; Protective Agents; Rats; Rats, Wistar; Stupor; Transaminases

2009
In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age.
    Therapeutic drug monitoring, 2009, Volume: 31, Issue:4

    Topics: Acetaminophen; Age Factors; Bilirubin; Glucuronides; Glucuronosyltransferase; Humans; Infant, Newborn; Metabolic Clearance Rate; Morphine; Polymorphism, Genetic; Propofol

2009
The effect of the aqueous extract of Kohautia grandiflora on paracetamol-induced liver damage in albino rats.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2009, Volume: 24, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Body Weight; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Liver; Plant Extracts; Rats; Rubiaceae; Serum Albumin

2009
Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity.
    Pakistan journal of pharmaceutical sciences, 2010, Volume: 23, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Liver; Male; Phytotherapy; Plant Extracts; Plant Leaves; Psidium; Rats; Rats, Wistar; Silymarin; Solvents

2010
Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients.
    Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; Cohort Studies; Creatinine; Diarrhea; Female; Humans; Length of Stay; Logistic Models; Malaysia; Male; Nausea; Pharmacoepidemiology; Potassium; Prevalence; Prognosis; Prothrombin Time; Retrospective Studies; Statistics, Nonparametric; Vomiting; Young Adult

2010
Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:8

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Biomarkers; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Glutathione Peroxidase; Hydroxyproline; Lipid Peroxidation; Liver; Lutein; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase

2010
Persistently increased acetaminophen concentrations in a patient with acute liver failure.
    Clinical chemistry, 2011, Volume: 57, Issue:1

    Topics: Acetaminophen; Adult; Bilirubin; Diagnosis, Differential; False Positive Reactions; Female; Humans; Liver Failure, Acute; Ultrafiltration

2011
Commentary.
    Clinical chemistry, 2011, Volume: 57, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Bilirubin; Diagnosis, Differential; False Positive Reactions; Female; Humans; Liver Failure, Acute

2011
Commentary.
    Clinical chemistry, 2011, Volume: 57, Issue:1

    Topics: Acetaminophen; Bilirubin; Colorimetry; Diagnosis, Differential; False Positive Reactions; Humans; Immunoassay; Liver Failure, Acute; Ultrafiltration

2011
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
    Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Humans; Liver Failure, Acute; Male; Middle Aged; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate; Transaminases

2011
Protective effects of syringic acid against acetaminophen-induced hepatic damage in albino rats.
    Journal of basic and clinical physiology and pharmacology, 2010, Volume: 21, Issue:4

    Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Bilirubin; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gallic Acid; Kidney; Lipid Peroxidation; Liver; Male; Protective Agents; Rats; Rats, Wistar

2010
Hepato-protective potential of carotenoid meso-zeaxanthin against paracetamol, CCl4 and ethanol induced toxicity.
    Indian journal of experimental biology, 2011, Volume: 49, Issue:1

    Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Biomarkers; Carbon Tetrachloride; Catalase; Dose-Response Relationship, Drug; Ethanol; Glutathione; Glutathione Peroxidase; Liver; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Superoxide Dismutase; Xanthophylls; Zeaxanthins

2011
Rhein protects against acetaminophen-induced hepatic and renal toxicity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:8

    Topics: Acetaminophen; Alanine Transaminase; Animals; Anthraquinones; Antioxidants; Bilirubin; Chemical and Drug Induced Liver Injury; Creatinine; Glutathione; Kidney; Kidney Diseases; Liver; Male; Nitric Oxide; Nitrogen; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2011
An alternative approach for detecting interferences in enzymatic acetaminophen assays.
    Clinical chemistry, 2011, Volume: 57, Issue:8

    Topics: Acetaminophen; Bilirubin; Enzymes; False Positive Reactions; Humans; Indicators and Reagents

2011
Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:12

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Andrographis; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Catalase; Chemical and Drug Induced Liver Injury; Female; Glutathione; Glutathione Peroxidase; India; Lipid Peroxides; Liver; Mice; Plant Extracts; Plants, Medicinal; Superoxide Dismutase; Swertia

2011
Screening of ethyl acetate extract of Bridelia micrantha for hepatoprotective and anti-oxidant activities on Wistar rats.
    Asian Pacific journal of tropical medicine, 2011, Volume: 4, Issue:10

    Topics: Acetaminophen; Acetates; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Bilirubin; Biological Assay; Biphenyl Compounds; Blood Proteins; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Euphorbiaceae; Ferric Compounds; Free Radicals; Humans; Male; Phytotherapy; Picrates; Plant Extracts; Plant Leaves; Rats; Rats, Wistar

2011
Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.
    Molecules (Basel, Switzerland), 2011, Dec-06, Volume: 16, Issue:12

    Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Biomarkers; Biphenyl Compounds; Butylated Hydroxytoluene; Chemical and Drug Induced Liver Injury; Clitoria; Flavonoids; Free Radical Scavengers; Inhibitory Concentration 50; Liver; Male; Mice; Phenols; Phytotherapy; Picrates; Plant Extracts; Plant Leaves; Protective Agents; Reference Standards

2011
Effect of Smilax zeylanica roots and rhizomes in paracetamol induced hepatotoxicity.
    Journal of complementary & integrative medicine, 2012, Nov-09, Volume: 9

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Antidotes; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Rhizome; Serum Albumin; Smilax

2012
Evaluation of the hepatoprotective Effects of Lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage.
    Molecules (Basel, Switzerland), 2012, Nov-23, Volume: 17, Issue:12

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Lantana; Liver; Mice; Oleanolic Acid; Plant Leaves; Protective Agents; Silymarin

2012
Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 56

    Topics: Acacia; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Alloxan; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Blood Glucose; Catalase; Chemical and Drug Induced Liver Injury; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glutathione; Glutathione Peroxidase; Hypoglycemic Agents; Liver; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2013
Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats.
    Asian Pacific journal of tropical biomedicine, 2012, Volume: 2, Issue:5

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Liver; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar

2012
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity.
    Journal of drug targeting, 2013, Volume: 21, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Body Weight; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Liposomes; Liver; Male; Peroxidase; Rats; Rats, Sprague-Dawley

2013
Effects of phospholipid hepatoprotectors on apoptosis during experimental liver pathology induced by isoniazid and paracetamol.
    Bulletin of experimental biology and medicine, 2013, Volume: 154, Issue:5

    Topics: Acetaminophen; Alkaline Phosphatase; Animals; Apoptosis; Bilirubin; Carotenoids; Chemical and Drug Induced Liver Injury; Drug Combinations; Granulocytes; Interleukin-10; Isoniazid; Liver Function Tests; Lymphocytes; Male; Phosphatidylcholines; Phospholipids; Rats; Succinic Acid; Transaminases; Tumor Necrosis Factor-alpha

2013
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats.
    Acta cirurgica brasileira, 2013, Volume: 28, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Fabaceae; Male; Plant Oils; Random Allocation; Rats; Rats, Wistar; Reproducibility of Results; Time Factors; Treatment Outcome

2013
Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
    Journal of dietary supplements, 2013, Volume: 10, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Chemical and Drug Induced Liver Injury; Lipid Peroxidation; Liver; Male; Malondialdehyde; Necrosis; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Triglycerides; Vitamin E; Zingiber officinale

2013
Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage.
    Toxicology and industrial health, 2016, Volume: 32, Issue:5

    Topics: Acetaminophen; Adenosine Triphosphatases; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Caesalpinia; Cajanus; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Interleukin-6; L-Lactate Dehydrogenase; Liver; Male; Nitric Oxide; Peroxidase; Plant Extracts; Plant Proteins; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2016
Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo.
    Journal of ethnopharmacology, 2014, May-14, Volume: 153, Issue:3

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Cell Survival; Dimethylnitrosamine; Glutathione; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Liver; Liver Cirrhosis; Male; Malondialdehyde; Protective Agents; Rats, Wistar; Reactive Oxygen Species; Serum Albumin; Superoxide Dismutase; Swertia; Xanthones

2014
Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure.
    Cytotherapy, 2014, Volume: 16, Issue:9

    Topics: Acetaminophen; Administration, Intravenous; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Humans; Liver; Liver Failure, Acute; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred BALB C; Umbilical Cord

2014
Some biochemical and haematological changes in rats pretreated with aqueous stem bark extract of Lophira lanceolata and intoxicated with paracetamol (acetaminophen).
    Journal of complementary & integrative medicine, 2014, Volume: 11, Issue:4

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Ochnaceae; Plant Bark; Plant Extracts; Plant Stems; Rats; Rats, Wistar; Water

2014
Bi-variate approach to negative interference of bilirubin towards an acetaminophen assay.
    Clinical biochemistry, 2015, Volume: 48, Issue:3

    Topics: Acetaminophen; Bilirubin; Biological Assay; Humans; Regression Analysis; Reproducibility of Results

2015
Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism.
    Environmental toxicology and pharmacology, 2014, Volume: 38, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gene Expression Regulation; Glutamate-Cysteine Ligase; Lonicera; Male; Mice; Mice, Inbred ICR; Polyphenols

2014
Attenuation of copaiba oil in hepatic damage in rats.
    Acta cirurgica brasileira, 2014, Volume: 29, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Corn Oil; Disease Models, Animal; Fabaceae; gamma-Glutamyltransferase; Male; Plant Oils; Random Allocation; Rats, Wistar; Treatment Outcome

2014
Evaluation of bilirubin displacement effect by acetaminophen in vitro.
    Annals of clinical biochemistry, 2015, Volume: 52, Issue:Pt 4

    Topics: Acetaminophen; Anti-Infective Agents; Antipyretics; Bilirubin; Binding, Competitive; Humans; In Vitro Techniques; Peroxidases; Protein Binding; Serum Albumin; Sulfisoxazole

2015
Protective effects of ethanolic extract of Nigella sativa seed in paracetamol induced acute hepatotoxicity in vivo.
    Pakistan journal of biological sciences : PJBS, 2014, Volume: 17, Issue:4

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Ethanol; Glutathione; Liver; Male; Necrosis; Nigella sativa; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Seeds; Solvents; Time Factors

2014
Lophirones B and C Attenuate Acetaminophen-Induced Liver Damage in Mice: Studies on Hepatic, Oxidative Stress and Inflammatory Biomarkers.
    Journal of biochemical and molecular toxicology, 2016, Volume: 30, Issue:10

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Benzopyrans; Bilirubin; Catalase; Chemical and Drug Induced Liver Injury; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Glutathione Reductase; Interleukin-6; Interleukin-8; Liver; Male; Malpighiaceae; Mice; Oxidative Stress; Plant Extracts; Serum Albumin; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2016
Falsely elevated acetaminophen levels in a patient with extreme hyperbilirubinemia.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2016, Jul-15, Volume: 73, Issue:14

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Colorimetry; Humans; Hyperbilirubinemia; Male

2016
GC-MS analysis and hepatoprotective activity of the n-hexane extract of Acrocarpus fraxinifolius leaves against paracetamol-induced hepatotoxicity in male albino rats.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Gas Chromatography-Mass Spectrometry; Hexanes; Lethal Dose 50; Lipids; Liver; Male; Organ Size; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats, Wistar; Solvents; Weight Loss

2017
Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice.
    Molecules (Basel, Switzerland), 2017, May-18, Volume: 22, Issue:5

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Catalase; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholesterol; Cyclooxygenase 2; Eriobotrya; Glutathione Peroxidase; Injections, Intraperitoneal; Interleukin-1beta; Interleukin-6; Liver; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Protective Agents; Reactive Oxygen Species; Superoxide Dismutase; Triglycerides; Triterpenes; Tumor Necrosis Factor-alpha

2017
Artificial liver support in pigs with acetaminophen-induced acute liver failure.
    World journal of gastroenterology, 2017, May-14, Volume: 23, Issue:18

    Topics: Acetaminophen; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Cell Nucleus; Creatinine; Disease Models, Animal; Hepatocytes; Liver; Liver Failure, Acute; Liver, Artificial; Sus scrofa; Swine; Time Factors

2017
Hepatoprotective evaluation of aqueous-ethanolic extract of Capparis decidua (Stems) in paracetamol induced hepatotoxicity in experimental rabbits.
    Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Capparis; Dose-Response Relationship, Drug; Female; Liver; Male; Phytochemicals; Plant Extracts; Plant Stems; Rabbits

2017
Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.
    Toxicology and applied pharmacology, 2017, 10-01, Volume: 332

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bilirubin; Biomarkers; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; HMGB1 Protein; Liver; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Photoacoustic Techniques

2017
Characterization of β-Estradiol 3-Glucuronidation in Rat Brain.
    Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:9

    Topics: Acetaminophen; Animals; Bilirubin; Brain Chemistry; Cerebellum; Estradiol; Glucuronides; Glucuronosyltransferase; Isoenzymes; Kinetics; Liver; Male; Microsomes; Rats; Rats, Sprague-Dawley; Serotonin

2017
Cuscuta arvensis Beyr "Dodder": In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats.
    Journal of medicinal food, 2018, Volume: 21, Issue:6

    Topics: Acetaminophen; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Catalase; Chemical and Drug Induced Liver Injury; Cuscuta; Female; Humans; Liver; Malondialdehyde; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2018
Performance evaluation of five commercial assays for detection of acetaminophen.
    Journal of clinical laboratory analysis, 2019, Volume: 33, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Bilirubin; Hemolysis; Humans; Immunoenzyme Techniques; Linear Models; Reproducibility of Results; Sensitivity and Specificity

2019
Thymoquinone and curcumin modify inducible nitric oxide synthase, caspase 3, and thioredoxin immunohistochemical expression in acetaminophen hepatotoxicity.
    Folia morphologica, 2019, Volume: 78, Issue:4

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzoquinones; Bilirubin; Caspase 3; Curcumin; Glutathione; Immunohistochemistry; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Superoxide Dismutase; Thioredoxins

2019
Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.
    Pediatrics international : official journal of the Japan Pediatric Society, 2021, Volume: 63, Issue:9

    Topics: Acetaminophen; Bilirubin; Glucose Oxidase; Humans; Infant; Infant, Newborn; Jaundice, Neonatal; Oxidoreductases; Peroxidase; Peroxidases; Retrospective Studies

2021
Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 140

    Topics: Acetaminophen; Acyclic Monoterpenes; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Bilirubin; Catalase; Chemical and Drug Induced Liver Injury; gamma-Glutamyltransferase; Globulins; Glutathione; Lipid Peroxidation; Liver; Male; Protective Agents; Rats, Sprague-Dawley; Rats, Wistar; Serum Albumin; Superoxide Dismutase

2021
Prevalence, severity, duration and resolution of cholestasis after acute liver failure.
    BMJ open gastroenterology, 2022, Volume: 9, Issue:1

    Topics: Acetaminophen; Adult; Alkaline Phosphatase; Bilirubin; Cholestasis; gamma-Glutamyltransferase; Humans; Liver Failure, Acute; Prevalence

2022
Acetaminophen administration leads to unexpected high unbound bilirubin levels.
    Pediatrics international : official journal of the Japan Pediatric Society, 2022, Volume: 64, Issue:1

    Topics: Acetaminophen; Bilirubin; Humans; Infant, Newborn; Jaundice, Neonatal

2022
Galium aparine L. protects against acetaminophen-induced hepatotoxicity in rats.
    Chemico-biological interactions, 2022, Oct-01, Volume: 366

    Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Anxiety Agents; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Galium; Hepatic Encephalopathy; Liver; Plant Extracts; Rats; Rats, Wistar

2022
Nilotinib alleviated acetaminophen-induced acute hepatic injury in mice through inhibiting HIF-1alpha/VEGF-signaling pathway.
    International immunopharmacology, 2022, Volume: 112

    Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Oxidative Stress; Signal Transduction; Superoxide Dismutase; Vascular Endothelial Growth Factor A

2022
GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study.
    Life sciences, 2022, Nov-15, Volume: 309

    Topics: Acetaminophen; Alkaloids; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Esters; Fatty Acids; Gas Chromatography-Mass Spectrometry; Lipids; Liver; Methanol; Piper; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Serum Albumin; Silymarin

2022
[Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:19

    Topics: Acetaminophen; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Liver; Mice; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction

2022
Fluctuations in unbound bilirubin levels during acetaminophen therapy for patent ductus arteriosus.
    Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1

    Topics: Acetaminophen; Bilirubin; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Premature; Persistent Fetal Circulation Syndrome

2023
Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats.
    BMC complementary medicine and therapies, 2023, Apr-01, Volume: 23, Issue:1

    Topics: Acetaminophen; Agave; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Gum Arabic; Methanol; Plant Extracts; Rats; Rats, Wistar; Silymarin

2023
A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
    Advanced healthcare materials, 2023, Volume: 12, Issue:24

    Topics: Acetaminophen; Animals; Bilirubin; Biomimetics; Cytochrome P-450 CYP2E1; Glutathione; Liver; Liver Failure, Acute; Mice; Reactive Oxygen Species

2023
Pharmacokinetics and safety of prolonged paracetamol treatment in neonates: An interventional cohort study.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:11

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Bilirubin; Cohort Studies; Humans; Infant; Infant, Newborn; Pain

2023
Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. to evaluate its hepatoprotective activity.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 1

    Topics: Acetaminophen; Animals; Antioxidants; Bilirubin; Chemical and Drug Induced Liver Injury; Cymbopogon; Liver; Phenols; Plant Extracts; Rats; Rats, Wistar; Silymarin; Terpenes

2024