acetaminophen and allopurinol

acetaminophen has been researched along with allopurinol in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (14.29)	18.7374
1990's	2 (4.76)	18.2507
2000's	18 (42.86)	29.6817
2010's	16 (38.10)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dybing, E	1
Johnson, GF; Kiser, EJ; Witte, DL	1
Feldman, S; Kramer, WG	1
Jaeschke, H	1
Nelson, SD; Tirmenstein, MA	1
Dubbelman, TM; Koster, JF; Van Steveninck, J	1
Gale, GR; Smith, AB	1
Asamoto, M; Fukushima, S; Hagiwara, A; Kurata, Y; Masui, T	1
Huang, PC; Lin, CC	1
Hanioka, K; Hojo, M; Miyata, M; Yamazoe, Y	1
Jaeschke, H; Knight, TR	1
Fujino, Y; Ku, Y; Kuroda, Y; Li, S; Suzuki, Y; Takahashi, T; Tanioka, Y; Tsujimura, T; Yoshida, I	1
Price, SL	1
Ali, S; Pawa, S	1
Andrade, P; Brinca, A; Gonçalo, M	1
Borchers, S; Findeisen, R; Krauss, M; Kuepfer, L; Lippert, J; Schaller, S	1
Bajt, ML; Jaeschke, H; Lebofsky, M; McGill, MR; Williams, CD	1
Kim, SR; Koh, BS; Lee, JH; Leem, DW; Moon, IJ; Park, HJ; Park, JW; Park, KH	1
Marks, DJ; Stimpson, PJ	1
Asprodini, EK; Begas, E; Kilindris, T; Kouretas, D; Kouvaras, E; Tsioutsioumi, A	1
Nakamura, R; Saito, Y	1

Reviews

3 review(s) available for acetaminophen and allopurinol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The computational prediction of pharmaceutical crystal structures and polymorphism. Advanced drug delivery reviews, 2004, Feb-23, Volume: 56, Issue:3 Topics: Acetaminophen; Allopurinol; Aspirin; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Computer Simulation; Crystallography; Databases, Factual; Diflunisal; Hormones; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Conformation; Molecular Structure; Pharmaceutical Preparations; Phase Transition; Software; Static Electricity; Technology, Pharmaceutical; Thermodynamics	2004
[Mechanisms of Severe Cutaneous Adverse Reactions and a New Treatment Strategy]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Volume: 139, Issue:12 Topics: Acetaminophen; Adrenal Cortex Hormones; Allopurinol; Antigens, Differentiation, T-Lymphocyte; Carbamazepine; CD8-Positive T-Lymphocytes; Cyclosporine; Epidermis; Etanercept; Fas Ligand Protein; HLA Antigens; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Japan; Lamotrigine; Plasma Exchange; Stevens-Johnson Syndrome; Tumor Necrosis Factor-alpha	2019

Other Studies

39 other study(ies) available for acetaminophen and allopurinol

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogPoct: a tool for lipophilicity determination in drug discovery. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Methyldopa binding to cells in culture. Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:1 Topics: Acetaminophen; Allopurinol; Animals; Ascorbic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Deferoxamine; Dimethylnitrosamine; Edetic Acid; Furosemide; Glutathione; Liver Neoplasms; Maleates; Methyldopa; Neoplasms, Experimental; Protein Binding; Rats; Superoxide Dismutase; Time Factors; Xanthines	1977
Serum uric acid determined by reversed-phase liquid chromatography with spectrophotometric detection. Clinical chemistry, 1978, Volume: 24, Issue:4 Topics: Acetaminophen; Allopurinol; Chromatography, Liquid; Drug Interactions; Humans; Methods; Oxypurinol; Salicylates; Spectrophotometry, Ultraviolet; Theophylline; Urate Oxidase; Uric Acid	1978
High-performance liquid chromatographic assay for allopurinol and oxipurinol in human plasma. Journal of chromatography, 1979, Jan-01, Volume: 162, Issue:1 Topics: Acetaminophen; Allopurinol; Chromatography, High Pressure Liquid; Humans; Methods; Oxypurinol; Pyrimidines	1979
Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Oxidation-Reduction; Oxygen; Xanthine Dehydrogenase; Xanthine Oxidase	1990
Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides. The Journal of biological chemistry, 1990, Feb-25, Volume: 265, Issue:6 Topics: Acetaminophen; Acetanilides; Adenine Nucleotides; Analgesics; Animals; Cytosol; Glutathione Peroxidase; Kinetics; Liver; Male; Mice; Oxidation-Reduction; Proteins; Reference Values; Sulfhydryl Compounds; Sulfurtransferases; Xanthine Dehydrogenase; Xanthine Oxidase	1990
Xanthine oxidase-catalysed oxidation of paracetamol. The Biochemical journal, 1989, May-01, Volume: 259, Issue:3 Topics: Acetaminophen; Catalysis; Horseradish Peroxidase; Hydroxides; Polymers; Xanthine Oxidase	1989
Interaction of caffeine with acetaminophen in mice: schedule dependency of the antagonism by caffeine of acetaminophen hepatotoxicity and the effects of caffeine metabolites, allopurinol, and diethyl ether. Research communications in chemical pathology and pharmacology, 1988, Volume: 59, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Allopurinol; Animals; Biotransformation; Caffeine; Ethanol; Ether; Ethyl Ethers; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA	1988
Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer letters, 1986, Volume: 32, Issue:2 Topics: Acetaminophen; Allopurinol; Aminocaproates; Animals; Biphenyl Compounds; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hydrogen-Ion Concentration; Indomethacin; Male; Nitrosamines; Rats; Rats, Inbred F344; Sodium; Urinary Bladder; Urinary Bladder Calculi; Urinary Bladder Neoplasms	1986
Antioxidant and hepatoprotective effects of Acathopanax senticosus. Phytotherapy research : PTR, 2000, Volume: 14, Issue:7 Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Free Radical Scavengers; Lipid Peroxidation; Liver; Male; Medicine, Chinese Traditional; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Taiwan; Xanthine Oxidase	2000
Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:9 Topics: Acetaminophen; Alanine Transaminase; Allopurinol; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Inhibitors; Fructose; Glucose; Imines; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Portal Vein; Rats; Rats, Sprague-Dawley; Sucrose; Xanthine Oxidase	2000
Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion. Toxicology and applied pharmacology, 2002, Jun-01, Volume: 181, Issue:2 Topics: Acetaminophen; Allopurinol; Animals; Antibodies, Antinuclear; Apoptosis; Caspase 3; Caspases; Drug Therapy, Combination; fas Receptor; Glutathione; Hepatocytes; In Situ Nick-End Labeling; Liver; Male; Mice; Mice, Inbred C3H; Mitochondria	2002
Successful 24-h preservation of canine small bowel using the cavitary two-layer (University of Wisconsin solution/perfluorochemical) cold storage method. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2002, Volume: 2, Issue:5 Topics: Acetaminophen; Adenosine; Allopurinol; Animals; Blood Glucose; Cold Temperature; Dogs; Fluorocarbons; Glutathione; Insulin; Intestine, Small; Organ Preservation; Organ Preservation Solutions; Raffinose	2002
Liver necrosis and fulminant hepatic failure in rats: protection by oxyanionic form of tungsten. Biochimica et biophysica acta, 2004, Apr-05, Volume: 1688, Issue:3 Topics: Acetaminophen; Alkaline Phosphatase; Allopurinol; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chloroform; Dimethyl Sulfoxide; Female; Lethal Dose 50; Liver; Liver Failure; Necrosis; Oxidative Stress; Rats; Rats, Wistar; Thioacetamide; Transaminases; Tungsten Compounds	2004
Patch testing in fixed drug eruptions--a 20-year review. Contact dermatitis, 2011, Volume: 65, Issue:4 Topics: Acetaminophen; Adult; Aged; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cetirizine; Cross Reactions; Drug Eruptions; Female; Gout Suppressants; Histamine Antagonists; Humans; Male; Middle Aged; Patch Tests; Retrospective Studies; Sensitivity and Specificity	2011
Integrating cellular metabolism into a multiscale whole-body model. PLoS computational biology, 2012, Volume: 8, Issue:10 Topics: Acetaminophen; Allopurinol; Ammonia; Chemical and Drug Induced Liver Injury; Computational Biology; Computer Simulation; Hepatocytes; Humans; Hyperuricemia; Inactivation, Metabolic; Liver; Metabolism; Models, Biological; Urea; Urea Cycle Disorders, Inborn; Uric Acid	2012
Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning. Toxicology and applied pharmacology, 2014, Feb-01, Volume: 274, Issue:3 Topics: Acetaminophen; Aldehyde Oxidase; Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Drug Overdose; Glutathione; JNK Mitogen-Activated Protein Kinases; Liver; Male; Metallothionein; Mice; Mice, Inbred C3H; Mitochondria; Oxypurinol; Phosphorylation; Xanthine Oxidase	2014
Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B4403 allele and lamotrigine. European journal of clinical pharmacology, 2015, Volume: 71, Issue:1* Topics: Acetaminophen; Acetazolamide; Adult; Aged; Aged, 80 and over; Alleles; Allopurinol; Anti-Bacterial Agents; Anticonvulsants; Asian People; Female; Genetic Predisposition to Disease; HLA-B Antigens; Humans; Lamotrigine; Male; Middle Aged; Plants, Medicinal; Republic of Korea; Stevens-Johnson Syndrome; Tertiary Care Centers; Triazines; Young Adult	2015
Leading articles in medical journals in 1966. British journal of hospital medicine (London, England : 2005), 2016, Volume: 77, Issue:10 Topics: Abortion, Induced; Acetaminophen; Adrenocortical Adenoma; Allopurinol; Analgesics; Antineoplastic Agents; Attitude of Health Personnel; Attitude to Health; Bird Fancier's Lung; Celiac Disease; Chemical and Drug Induced Liver Injury; Dermatitis Herpetiformis; Drug Discovery; Gout; Gout Suppressants; Graft Rejection; Granulomatous Disease, Chronic; History, 20th Century; Humans; Medicare; Periodicals as Topic; Publishing; United Kingdom; United States	2016
Dietary effects of Sideritis scardica "mountain tea" on human in vivo activities of xenobiotic metabolizing enzymes in healthy subjects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 122 Topics: Acetaminophen; Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Dietary Exposure; Female; Glucuronosyltransferase; Healthy Volunteers; Herb-Drug Interactions; Humans; Male; Middle Aged; Plant Components, Aerial; Saliva; Sideritis; Substrate Specificity; Teas, Herbal; Xanthine Oxidase; Xenobiotics; Young Adult	2018